ZNRF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.89821801
2multicellular organism reproduction (GO:0032504)9.70642988
3protein targeting to Golgi (GO:0000042)9.65086924
4plasma membrane fusion (GO:0045026)9.34658099
5epithelial cilium movement (GO:0003351)9.25727100
6establishment of protein localization to Golgi (GO:0072600)9.23790305
7motile cilium assembly (GO:0044458)9.14725773
8retrograde transport, vesicle recycling within Golgi (GO:0000301)9.12696652
9axonemal dynein complex assembly (GO:0070286)8.99939948
10reproduction (GO:0000003)8.64075396
11regulation of cilium movement (GO:0003352)8.05805580
12organic cation transport (GO:0015695)7.46342422
13cilium movement (GO:0003341)7.40832210
14negative regulation of inclusion body assembly (GO:0090084)7.28547738
15centriole replication (GO:0007099)7.08455865
16sperm capacitation (GO:0048240)7.03952755
17spermatogenesis (GO:0007283)7.02969953
18protein localization to Golgi apparatus (GO:0034067)7.02788914
19cilium or flagellum-dependent cell motility (GO:0001539)7.01304868
20male gamete generation (GO:0048232)7.00340048
21rRNA methylation (GO:0031167)6.99253884
22synaptonemal complex organization (GO:0070193)6.97384956
23synaptonemal complex assembly (GO:0007130)6.93912926
24single fertilization (GO:0007338)6.81081923
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.48120427
26gamete generation (GO:0007276)6.42736436
27chromosome condensation (GO:0030261)6.39804291
28male meiosis (GO:0007140)6.35334075
29centriole assembly (GO:0098534)6.22501402
30regulation of inclusion body assembly (GO:0090083)6.21314169
31DNA packaging (GO:0006323)6.20498381
32regulation of centriole replication (GO:0046599)6.16993264
33microtubule depolymerization (GO:0007019)6.12276308
34rRNA modification (GO:0000154)6.06842236
35piRNA metabolic process (GO:0034587)6.02359681
36fertilization (GO:0009566)5.96991547
37phosphatidylethanolamine biosynthetic process (GO:0006646)5.86297321
38calcium ion-dependent exocytosis (GO:0017156)5.85054223
39cellular process involved in reproduction in multicellular organism (GO:0022412)5.55986103
40glomerular visceral epithelial cell development (GO:0072015)5.53454555
41germ cell development (GO:0007281)5.51561506
42spermatid nucleus differentiation (GO:0007289)5.39699533
43phosphatidylethanolamine metabolic process (GO:0046337)5.37849486
44sequestering of actin monomers (GO:0042989)5.33911322
45microtubule nucleation (GO:0007020)5.14873065
46cell recognition (GO:0008037)5.13447529
47glomerular epithelial cell development (GO:0072310)5.13048304
48seminiferous tubule development (GO:0072520)5.07788472
49microtubule severing (GO:0051013)5.07639091
50multicellular organismal reproductive process (GO:0048609)5.03496965
51ventricular system development (GO:0021591)4.92975926
52sexual reproduction (GO:0019953)4.91088825
53regulation of microtubule-based movement (GO:0060632)4.76655001
54glycerol ether metabolic process (GO:0006662)4.73362635
55nuclear pore complex assembly (GO:0051292)4.61782827
56chromosome organization involved in meiosis (GO:0070192)4.54468561
57male meiosis I (GO:0007141)4.52832272
58single strand break repair (GO:0000012)4.43629840
59ether metabolic process (GO:0018904)4.36990180
60response to pheromone (GO:0019236)4.35948802
61left/right pattern formation (GO:0060972)4.34471828
62positive regulation of Rab GTPase activity (GO:0032851)4.30154600
63regulation of Rab GTPase activity (GO:0032313)4.30154600
64multicellular organismal movement (GO:0050879)4.07682988
65musculoskeletal movement (GO:0050881)4.07682988
66multicellular organismal development (GO:0007275)4.05526012
67DNA methylation involved in gamete generation (GO:0043046)3.99328942
68chaperone-mediated protein complex assembly (GO:0051131)3.99137101
69meiotic nuclear division (GO:0007126)3.95855951
70positive regulation of macrophage activation (GO:0043032)3.93367109
71RNA localization (GO:0006403)3.87413270
72RNA destabilization (GO:0050779)3.80774165
73nuclear pore organization (GO:0006999)3.71819978
74cellular ketone body metabolic process (GO:0046950)3.69456971
75regulation of transcription involved in cell fate commitment (GO:0060850)3.67008382
76intra-Golgi vesicle-mediated transport (GO:0006891)3.65814491
77protein polyglutamylation (GO:0018095)3.64137095
78interferon-gamma secretion (GO:0072643)3.62426836
79meiosis I (GO:0007127)3.61257888
80pore complex assembly (GO:0046931)3.56881963
81genitalia morphogenesis (GO:0035112)3.56494458
82polyamine biosynthetic process (GO:0006596)3.52100255
83regulation of spindle checkpoint (GO:0090231)3.49508223
84carnitine transport (GO:0015879)3.38325309
85amino-acid betaine transport (GO:0015838)3.38325309
86protein K11-linked deubiquitination (GO:0035871)3.34038796
87nucleus organization (GO:0006997)3.31902564
88protein refolding (GO:0042026)3.28408750
89receptor recycling (GO:0001881)3.27949124
90membrane protein intracellular domain proteolysis (GO:0031293)3.25754158
91cellular response to pH (GO:0071467)3.24892149
92coenzyme catabolic process (GO:0009109)3.24886858
93ketone body metabolic process (GO:1902224)3.24582462
94protein-DNA complex disassembly (GO:0032986)3.23783643
95nucleosome disassembly (GO:0006337)3.23783643
96carnitine transmembrane transport (GO:1902603)3.19108938
97protein localization to cilium (GO:0061512)3.16329937
98meiotic cell cycle (GO:0051321)3.12024014
99microtubule polymerization or depolymerization (GO:0031109)3.10599137
100chromatin silencing (GO:0006342)3.07240103
101protein depolymerization (GO:0051261)3.03278511
102tRNA methylation (GO:0030488)3.03066572
103RNA methylation (GO:0001510)2.91014878
104glycolytic process (GO:0006096)2.89213024
105regulation of phosphoprotein phosphatase activity (GO:0043666)2.89024292
106mitotic sister chromatid cohesion (GO:0007064)2.88720180
107monoubiquitinated protein deubiquitination (GO:0035520)2.88186617
108negative regulation of Rho protein signal transduction (GO:0035024)2.87566810
109phospholipid translocation (GO:0045332)2.82538399
110lipid translocation (GO:0034204)2.82538399
111regulation of cilium assembly (GO:1902017)2.81136972
112regulation of meiosis I (GO:0060631)2.79842200
113positive regulation of guanylate cyclase activity (GO:0031284)2.79625386
114Golgi to endosome transport (GO:0006895)2.73343860
115nucleoside diphosphate phosphorylation (GO:0006165)2.68918238
116mitochondrion degradation (GO:0000422)2.67237881
117axoneme assembly (GO:0035082)2.67111323
118response to acidic pH (GO:0010447)2.66300176
119polyol catabolic process (GO:0046174)2.62000733
120peptidyl-glutamic acid modification (GO:0018200)2.61257517
121meiotic cell cycle process (GO:1903046)2.61256420
122cilium organization (GO:0044782)2.60005551
123negative regulation of organelle assembly (GO:1902116)2.58229196
124mitochondrial fission (GO:0000266)2.56912298
125alditol metabolic process (GO:0019400)2.53965922
126cellular component assembly involved in morphogenesis (GO:0010927)2.52264865
127microtubule-based movement (GO:0007018)2.51038321
128cilium morphogenesis (GO:0060271)2.47723706
129cilium assembly (GO:0042384)2.46848817
130cell wall macromolecule catabolic process (GO:0016998)14.4012268
131cell wall macromolecule metabolic process (GO:0044036)14.4012268
132sperm motility (GO:0030317)13.8229797
133acrosome reaction (GO:0007340)12.9340547
134fusion of sperm to egg plasma membrane (GO:0007342)12.2722274
135sperm-egg recognition (GO:0035036)11.7700146
136acrosome assembly (GO:0001675)11.4736820
137binding of sperm to zona pellucida (GO:0007339)10.8987678
138cell-cell recognition (GO:0009988)10.5400043

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.34287114
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.67190878
3EZH2_22144423_ChIP-Seq_EOC_Human4.02629855
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.94502320
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.43412231
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.31918575
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.25513322
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.07313349
9FUS_26573619_Chip-Seq_HEK293_Human3.06321749
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72739426
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.65874754
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.50255433
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.43414891
14* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.35364047
15VDR_22108803_ChIP-Seq_LS180_Human2.25387124
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.08376959
17ZNF274_21170338_ChIP-Seq_K562_Hela2.06825595
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89096078
19ELK4_26923725_Chip-Seq_MESODERM_Mouse1.88713719
20* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80476904
21VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.79780887
22SOX2_22085726_ChIP-Seq_NPCs_Mouse1.75731619
23DROSHA_22980978_ChIP-Seq_HELA_Human1.74641464
24KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.74028722
25GATA3_21867929_ChIP-Seq_CD8_Mouse1.71067485
26MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.66643379
27SMAD4_21741376_ChIP-Seq_EPCs_Human1.66215547
28P300_19829295_ChIP-Seq_ESCs_Human1.65950024
29ERA_21632823_ChIP-Seq_H3396_Human1.65078665
30* RAC3_21632823_ChIP-Seq_H3396_Human1.64377156
31TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.64116270
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62029358
33FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.61468309
34* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60576652
35TAF2_19829295_ChIP-Seq_ESCs_Human1.60472089
36ER_23166858_ChIP-Seq_MCF-7_Human1.59730254
37* STAT1_17558387_ChIP-Seq_HELA_Human1.57739737
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.57101801
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.56242725
40MYC_19829295_ChIP-Seq_ESCs_Human1.56072094
41CBX2_22325352_ChIP-Seq_293T-Rex_Human1.55139579
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.54536819
43RBPJ_21746931_ChIP-Seq_IB4_Human1.52409208
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52258764
45GBX2_23144817_ChIP-Seq_PC3_Human1.51007036
46AR_25329375_ChIP-Seq_VCAP_Human1.49913316
47WDR5_24793694_ChIP-Seq_LNCAP_Human1.48597917
48PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.47082144
49P53_21459846_ChIP-Seq_SAOS-2_Human1.46279106
50ETV1_20927104_ChIP-Seq_GIST48_Human1.45381323
51TAF15_26573619_Chip-Seq_HEK293_Human1.43270093
52TBL1_22424771_ChIP-Seq_293T_Human1.40204580
53LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.39893308
54NFYB_21822215_ChIP-Seq_K562_Human1.39371385
55PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.39014785
56HNFA_21074721_ChIP-Seq_CACO-2_Human1.38514960
57CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.37477057
58REST_21632747_ChIP-Seq_MESCs_Mouse1.37063151
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34662124
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.34048821
61* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33913716
62TAL1_26923725_Chip-Seq_HPCs_Mouse1.32218862
63KDM2B_26808549_Chip-Seq_REH_Human1.32176626
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.32157894
65PHF8_20622853_ChIP-Seq_HELA_Human1.31888620
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.31499528
67SMAD4_21799915_ChIP-Seq_A2780_Human1.30667900
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30628005
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.30263623
70RAD21_21589869_ChIP-Seq_MESCs_Mouse1.29723211
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28489031
72* OCT4_20526341_ChIP-Seq_ESCs_Human1.27722335
73STAT3_23295773_ChIP-Seq_U87_Human1.27488008
74CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26706167
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26589440
76* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25215307
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25134396
78PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.25043263
79* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24562108
80* CBP_20019798_ChIP-Seq_JUKART_Human1.24413616
81* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24413616
82SMC4_20622854_ChIP-Seq_HELA_Human1.24139851
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22716871
84GF1_26923725_Chip-Seq_HPCs_Mouse1.22389927
85GATA3_21878914_ChIP-Seq_MCF-7_Human1.21857522
86* SMAD3_21741376_ChIP-Seq_ESCs_Human1.20333676
87* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19973139
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19753246
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19483233
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.19232922
91GATA6_21074721_ChIP-Seq_CACO-2_Human1.19190075
92SALL1_21062744_ChIP-ChIP_HESCs_Human1.18636102
93CEBPB_22108803_ChIP-Seq_LS180_Human1.18555979
94MYC_27129775_Chip-Seq_CORNEA_Mouse1.17330283
95ERG_20517297_ChIP-Seq_VCAP_Human1.17307560
96GATA3_21867929_ChIP-Seq_TH1_Mouse1.17135936
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17004208
98CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16529823
99GATA1_19941827_ChIP-Seq_MEL86_Mouse1.16464469
100RARA_24833708_ChIP-Seq_LIVER_Mouse1.16315793
101SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16279407
102SPI1_26923725_Chip-Seq_HPCs_Mouse1.15878846
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15649898
104TP53_18474530_ChIP-ChIP_U2OS_Human1.15076555
105JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.14828800
106* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14013402
107RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13965652
108EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.13267672
109ELF1_20517297_ChIP-Seq_JURKAT_Human1.13263531
110E2F1_17053090_ChIP-ChIP_MCF-7_Human1.12660508
111PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12447856
112GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.12403783
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12101902
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11314254
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11314254
116* RUNX2_22187159_ChIP-Seq_PCA_Human1.11129632
117* TP63_22573176_ChIP-Seq_HFKS_Human1.11071261
118YY1_22570637_ChIP-Seq_MALME-3M_Human1.10152616
119RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09911369
120FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09668077
121ESET_19884257_ChIP-Seq_ESCs_Mouse1.08909761
122NFYA_21822215_ChIP-Seq_K562_Human1.08818035
123KAP1_22055183_ChIP-Seq_ESCs_Mouse1.08699858
124NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08507000
125PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08123706
126* CTCF_20526341_ChIP-Seq_ESCs_Human1.08019038
127P68_20966046_ChIP-Seq_HELA_Human1.07535262
128AR_21572438_ChIP-Seq_LNCaP_Human1.07448064
129TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06474715
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06038423
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05793685
132BCOR_27268052_Chip-Seq_Bcells_Human1.05585118
133LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05051931
134* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03984831
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03751060
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03321443
137SOX11_22085726_ChIP-Seq_ESNs_Mouse1.02920627
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01718256
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01371219
140* SMAD4_21741376_ChIP-Seq_HESCs_Human1.00795927
141E2F1_20622854_ChIP-Seq_HELA_Human1.00034772
142EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99146840
143PRDM14_20953172_ChIP-Seq_ESCs_Human0.98458326
144BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98127369
145NANOG_19829295_ChIP-Seq_ESCs_Human0.98096302
146SOX2_19829295_ChIP-Seq_ESCs_Human0.98096302
147NFE2_27457419_Chip-Seq_LIVER_Mouse0.97983094
148NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97513268
149CBX2_27304074_Chip-Seq_ESCs_Mouse0.97017605
150* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96376304
151FLI1_21867929_ChIP-Seq_CD8_Mouse0.96215910
152MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95018590
153CTCF_27219007_Chip-Seq_Bcells_Human0.95016381
154RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93548249
155SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93332733
156PHF8_20622854_ChIP-Seq_HELA_Human0.93193692
157KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92873295
158BCL6_27268052_Chip-Seq_Bcells_Human0.92393077
159SOX2_21211035_ChIP-Seq_LN229_Human0.91740221
160CRX_20693478_ChIP-Seq_RETINA_Mouse0.91693601
161PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91495564
162SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91038013
163NANOG_18555785_Chip-Seq_ESCs_Mouse0.89889526
164NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87742977
165CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86791344
166* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.86707816
167NANOG_20526341_ChIP-Seq_ESCs_Human0.86098819

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.93898731
2MP0001929_abnormal_gametogenesis5.43439546
3MP0008877_abnormal_DNA_methylation3.30711794
4MP0001348_abnormal_lacrimal_gland3.25412299
5MP0002161_abnormal_fertility/fecundity3.21198119
6MP0002210_abnormal_sex_determination3.12798516
7MP0005670_abnormal_white_adipose2.99742045
8MP0001145_abnormal_male_reproductive2.72892123
9MP0001485_abnormal_pinna_reflex2.60622720
10MP0002822_catalepsy2.36361062
11MP0000653_abnormal_sex_gland2.34939584
12MP0005423_abnormal_somatic_nervous2.24391267
13MP0003718_maternal_effect2.11920085
14MP0003646_muscle_fatigue2.11791449
15MP0001486_abnormal_startle_reflex2.08562339
16MP0002160_abnormal_reproductive_system2.06467118
17MP0005410_abnormal_fertilization16.9654734
18MP0004233_abnormal_muscle_weight1.88020317
19MP0004859_abnormal_synaptic_plasticity1.86413654
20MP0002132_abnormal_respiratory_system1.73595680
21MP0002653_abnormal_ependyma_morphology1.67235915
22MP0005451_abnormal_body_composition1.66575000
23MP0005379_endocrine/exocrine_gland_phen1.62487214
24MP0001963_abnormal_hearing_physiology1.36062831
25MP0009697_abnormal_copulation1.35790481
26MP0002138_abnormal_hepatobiliary_system1.24070179
27MP0001905_abnormal_dopamine_level1.22129472
28MP0005310_abnormal_salivary_gland1.19391936
29MP0000026_abnormal_inner_ear1.16800578
30MP0002572_abnormal_emotion/affect_behav1.15519296
31MP0005623_abnormal_meninges_morphology1.01425952
32MP0000678_abnormal_parathyroid_gland1.00636349
33MP0002067_abnormal_sensory_capabilities0.99904214
34MP0006276_abnormal_autonomic_nervous0.99634744
35MP0005389_reproductive_system_phenotype0.99611699
36MP0002234_abnormal_pharynx_morphology0.99334222
37MP0001984_abnormal_olfaction0.98900439
38MP0001765_abnormal_ion_homeostasis0.96789129
39MP0005646_abnormal_pituitary_gland0.92888205
40MP0000955_abnormal_spinal_cord0.92817807
41MP0003136_yellow_coat_color0.91073718
42MP0002557_abnormal_social/conspecific_i0.89494257
43MP0002249_abnormal_larynx_morphology0.86101788
44MP0005395_other_phenotype0.85849297
45MP0002272_abnormal_nervous_system0.85422427
46MP0002735_abnormal_chemical_nociception0.82510719
47MP0002282_abnormal_trachea_morphology0.82143588
48MP0005167_abnormal_blood-brain_barrier0.81633815
49MP0003115_abnormal_respiratory_system0.78006121
50MP0001501_abnormal_sleep_pattern0.77971554
51MP0003880_abnormal_central_pattern0.77382711
52MP0006292_abnormal_olfactory_placode0.75992595
53MP0005332_abnormal_amino_acid0.74513463
54MP0000230_abnormal_systemic_arterial0.72706359
55MP0002063_abnormal_learning/memory/cond0.70942280
56MP0003635_abnormal_synaptic_transmissio0.70211854
57MP0001919_abnormal_reproductive_system0.68815430
58MP0006036_abnormal_mitochondrial_physio0.68722478
59MP0005248_abnormal_Harderian_gland0.67766572
60MP0009745_abnormal_behavioral_response0.67621983
61MP0005647_abnormal_sex_gland0.66231963
62MP0004510_myositis0.65496975
63MP0003329_amyloid_beta_deposits0.63890840
64MP0002733_abnormal_thermal_nociception0.63321132
65MP0005083_abnormal_biliary_tract0.60914995
66MP0003077_abnormal_cell_cycle0.60734070
67MP0002184_abnormal_innervation0.60706313
68MP0009053_abnormal_anal_canal0.59686167
69MP0004085_abnormal_heartbeat0.59200036
70MP0002127_abnormal_cardiovascular_syste0.59174315
71MP0005084_abnormal_gallbladder_morpholo0.58478206
72MP0005666_abnormal_adipose_tissue0.57758354
73MP0005377_hearing/vestibular/ear_phenot0.57488651
74MP0003878_abnormal_ear_physiology0.57488651
75MP0009046_muscle_twitch0.57082196
76MP0004036_abnormal_muscle_relaxation0.56700863
77MP0002734_abnormal_mechanical_nocicepti0.56496692
78MP0005636_abnormal_mineral_homeostasis0.56422008
79MP0003011_delayed_dark_adaptation0.55668856
80MP0002269_muscular_atrophy0.54307693
81MP0001970_abnormal_pain_threshold0.52418370
82MP0000049_abnormal_middle_ear0.50975028
83MP0005595_abnormal_vascular_smooth0.50806109
84MP0000358_abnormal_cell_content/0.49944442
85MP0002882_abnormal_neuron_morphology0.49708391
86MP0010329_abnormal_lipoprotein_level0.48957855
87MP0008058_abnormal_DNA_repair0.48945707
88MP0000534_abnormal_ureter_morphology0.48761182
89MP0003137_abnormal_impulse_conducting0.48738193
90MP0008872_abnormal_physiological_respon0.48500210
91MP0009278_abnormal_bone_marrow0.46499154
92MP0001440_abnormal_grooming_behavior0.45034107
93MP0005397_hematopoietic_system_phenotyp0.44870505
94MP0001545_abnormal_hematopoietic_system0.44870505
95MP0001324_abnormal_eye_pigmentation0.44853804
96MP0003699_abnormal_female_reproductive0.43354701
97MP0004084_abnormal_cardiac_muscle0.42290681
98MP0002736_abnormal_nociception_after0.41620222
99MP0001293_anophthalmia0.41091646
100MP0002752_abnormal_somatic_nervous0.41033387
101MP0002064_seizures0.40567404
102MP0001727_abnormal_embryo_implantation0.40230564
103MP0003787_abnormal_imprinting0.39994556
104MP0004811_abnormal_neuron_physiology0.39651659
105MP0008995_early_reproductive_senescence0.38752639
106MP0001661_extended_life_span0.37698714
107MP0001764_abnormal_homeostasis0.37557636
108MP0006035_abnormal_mitochondrial_morpho0.36918776
109MP0004133_heterotaxia0.36241168
110MP0003950_abnormal_plasma_membrane0.34758606
111MP0003942_abnormal_urinary_system0.34557692
112MP0002139_abnormal_hepatobiliary_system0.34009925
113MP0000604_amyloidosis0.33526669
114MP0002928_abnormal_bile_duct0.33314646
115MP0009115_abnormal_fat_cell0.32397223
116MP0000751_myopathy0.31639248
117MP0004270_analgesia0.31032343
118MP0002909_abnormal_adrenal_gland0.29704101
119MP0005253_abnormal_eye_physiology0.29502355
120MP0005551_abnormal_eye_electrophysiolog0.28250909
121MP0003879_abnormal_hair_cell0.27813194
122MP0003633_abnormal_nervous_system0.27619546
123MP0003948_abnormal_gas_homeostasis0.26260700
124MP0001730_embryonic_growth_arrest0.26254849
125MP0003861_abnormal_nervous_system0.25843996
126MP0005391_vision/eye_phenotype0.25253619
127MP0002169_no_abnormal_phenotype0.24969496
128MP0002873_normal_phenotype0.24747765
129MP0002152_abnormal_brain_morphology0.24701433
130MP0003959_abnormal_lean_body0.24384675
131MP0001849_ear_inflammation0.23539087
132MP0001968_abnormal_touch/_nociception0.23440358
133MP0010094_abnormal_chromosome_stability0.23418321
134MP0002971_abnormal_brown_adipose0.23234707
135MP0000569_abnormal_digit_pigmentation0.22948357
136MP0003631_nervous_system_phenotype0.22615346
137MP0000749_muscle_degeneration0.22515904
138MP0004019_abnormal_vitamin_homeostasis0.22126247
139MP0002295_abnormal_pulmonary_circulatio0.21458922
140MP0003111_abnormal_nucleus_morphology0.21175518
141MP0004742_abnormal_vestibular_system0.18298541
142MP0008875_abnormal_xenobiotic_pharmacok0.17989593
143MP0005375_adipose_tissue_phenotype0.17049097
144MP0003183_abnormal_peptide_metabolism0.17044512
145MP0002102_abnormal_ear_morphology0.16846203
146MP0002092_abnormal_eye_morphology0.16597952
147MP0008569_lethality_at_weaning0.16542258
148MP0002084_abnormal_developmental_patter0.16355157
149MP0003936_abnormal_reproductive_system0.15916479
150MP0004043_abnormal_pH_regulation0.15599461
151MP0004087_abnormal_muscle_fiber0.15586180
152MP0002229_neurodegeneration0.15310095
153MP0005319_abnormal_enzyme/_coenzyme0.15213622
154MP0005365_abnormal_bile_salt0.15026296
155MP0000001_mammalian_phenotype0.14744837
156MP0005257_abnormal_intraocular_pressure0.14659289
157MP0000462_abnormal_digestive_system0.14595503
158MP0002106_abnormal_muscle_physiology0.14392785
159MP0008961_abnormal_basal_metabolism0.14369213
160MP0000313_abnormal_cell_death0.13892324
161MP0002118_abnormal_lipid_homeostasis0.13743936

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.01260462
2Abnormal respiratory motile cilium morphology (HP:0005938)8.91850420
3Abnormal respiratory epithelium morphology (HP:0012253)8.91850420
4Rhinitis (HP:0012384)7.54165164
5Chronic bronchitis (HP:0004469)7.32290614
6Infertility (HP:0000789)7.26453555
7Chronic hepatic failure (HP:0100626)6.78812273
8Abnormal ciliary motility (HP:0012262)6.73086918
9Nasal polyposis (HP:0100582)6.49896166
10Severe visual impairment (HP:0001141)5.44804374
11Abnormality of the nasal mucosa (HP:0000433)5.34908028
12Cone-rod dystrophy (HP:0000548)4.66176258
13Male infertility (HP:0003251)4.64875121
14Bronchitis (HP:0012387)4.47580677
15Nephronophthisis (HP:0000090)4.44317320
16Bronchiectasis (HP:0002110)4.40489864
17Menstrual irregularities (HP:0000858)4.31373150
18Progressive sensorineural hearing impairment (HP:0000408)4.29202412
19Resting tremor (HP:0002322)4.16651634
20Hyperkalemia (HP:0002153)3.90774412
21Hypoalphalipoproteinemia (HP:0003233)3.86815160
22Abnormality of macular pigmentation (HP:0008002)3.78395821
23Abnormal spermatogenesis (HP:0008669)3.77576575
24Bony spicule pigmentary retinopathy (HP:0007737)3.73942131
25Renovascular hypertension (HP:0100817)3.72002643
26Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.68969226
27Attenuation of retinal blood vessels (HP:0007843)3.54536696
28Progressive cerebellar ataxia (HP:0002073)3.54407517
29Amelogenesis imperfecta (HP:0000705)3.49391462
30Hypoplasia of the thymus (HP:0000778)3.47671618
31Aplasia/Hypoplasia of the earlobes (HP:0009906)3.42973161
32Abnormality of dental color (HP:0011073)3.41214572
33Abnormality of the renal medulla (HP:0100957)3.29153591
34Myokymia (HP:0002411)3.27279044
35Recurrent otitis media (HP:0000403)3.22161655
36Generalized aminoaciduria (HP:0002909)3.14059697
37Insulin-resistant diabetes mellitus (HP:0000831)3.06540750
38Truncal obesity (HP:0001956)3.02455586
39Postural instability (HP:0002172)2.99665249
40Cholecystitis (HP:0001082)2.93750178
41Abnormal gallbladder physiology (HP:0012438)2.93750178
42Tubular atrophy (HP:0000092)2.93642596
43Increased purine levels (HP:0004368)2.92471733
44Hyperuricemia (HP:0002149)2.92471733
45Impulsivity (HP:0100710)2.83454233
46Recurrent sinusitis (HP:0011108)2.83097408
47Portal hypertension (HP:0001409)2.82696862
48Tubulointerstitial nephritis (HP:0001970)2.73505676
49Subcapsular cataract (HP:0000523)2.69574762
50Molar tooth sign on MRI (HP:0002419)2.66943902
51Abnormality of midbrain morphology (HP:0002418)2.66943902
52Tubulointerstitial abnormality (HP:0001969)2.64328328
53Optic nerve hypoplasia (HP:0000609)2.64310841
54Facial shape deformation (HP:0011334)2.62858034
55Potter facies (HP:0002009)2.62858034
56Abnormality of the hepatic vasculature (HP:0006707)2.61077044
57Azoospermia (HP:0000027)2.59567534
58Recurrent bronchitis (HP:0002837)2.57774052
59Intellectual disability, moderate (HP:0002342)2.54931572
60Focal segmental glomerulosclerosis (HP:0000097)2.48570258
61Progressive hearing impairment (HP:0001730)2.40538106
62Double outlet right ventricle (HP:0001719)2.39957281
63Congenital malformation of the right heart (HP:0011723)2.39957281
64Dyschromatopsia (HP:0007641)2.39905335
65Choroideremia (HP:0001139)2.39242586
66Tubulointerstitial fibrosis (HP:0005576)2.37739562
67Osteomalacia (HP:0002749)2.36253807
68Medial flaring of the eyebrow (HP:0010747)2.35777070
69Pancreatic fibrosis (HP:0100732)2.35001751
70Atonic seizures (HP:0010819)2.33693711
71Hypoalbuminemia (HP:0003073)2.29905583
72Abnormal albumin level (HP:0012116)2.29905583
73Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.26858272
74Gonadotropin excess (HP:0000837)2.23942916
75Occipital encephalocele (HP:0002085)2.12925054
76Abnormality of the costochondral junction (HP:0000919)2.12919709
77Glycosuria (HP:0003076)2.10242470
78Abnormality of urine glucose concentration (HP:0011016)2.10242470
79Abnormal drinking behavior (HP:0030082)2.08806160
80Polydipsia (HP:0001959)2.08806160
81Abnormal rod and cone electroretinograms (HP:0008323)2.08127514
82Obsessive-compulsive behavior (HP:0000722)2.05612801
83Enlarged epiphyses (HP:0010580)2.02239060
84Absent/shortened dynein arms (HP:0200106)12.6968316
85Dynein arm defect of respiratory motile cilia (HP:0012255)12.6968316
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.6453538
87Abnormality of purine metabolism (HP:0004352)1.99156789
88Decreased central vision (HP:0007663)1.98763855
89Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96451466
90Spastic tetraparesis (HP:0001285)1.95873763
91Neurofibrillary tangles (HP:0002185)1.94937854
92Hypolipoproteinemia (HP:0010981)1.94021208
93Hemorrhage of the eye (HP:0011885)1.92623563
94Abnormality of potassium homeostasis (HP:0011042)1.91945117
95Sclerocornea (HP:0000647)1.90245442
96Stage 5 chronic kidney disease (HP:0003774)1.89074356
97Pendular nystagmus (HP:0012043)1.88161543
98Genetic anticipation (HP:0003743)1.85708456
99Pancreatic cysts (HP:0001737)1.85190215
100Growth hormone deficiency (HP:0000824)1.85040835
101Muscle fiber atrophy (HP:0100295)1.84878789
102Glomerulosclerosis (HP:0000096)1.84754965
103Type 2 muscle fiber atrophy (HP:0003554)1.84700681
104Abnormality of renal excretion (HP:0011036)1.83812303
105Hypophosphatemic rickets (HP:0004912)1.80317080
106Abnormality of lateral ventricle (HP:0030047)1.74156692
107Heterotopia (HP:0002282)1.73719027
108Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73206534
109Postaxial foot polydactyly (HP:0001830)1.69704267
110Photophobia (HP:0000613)1.68935965
111Aplasia/Hypoplasia of the sacrum (HP:0008517)1.68041122
112Fetal akinesia sequence (HP:0001989)1.67815720
113Morphological abnormality of the inner ear (HP:0011390)1.66911661
114Bilateral sensorineural hearing impairment (HP:0008619)1.66473924
115Abnormality of the renal cortex (HP:0011035)1.66463911
116Congenital sensorineural hearing impairment (HP:0008527)1.66438576
117Cystic liver disease (HP:0006706)1.66297569
118Congenital hepatic fibrosis (HP:0002612)1.66110158
119Hypoplastic ischia (HP:0003175)1.64652896
120Abnormality of the neuromuscular junction (HP:0003398)1.62748683
121Fatigable weakness (HP:0003473)1.62748683
122Esophageal atresia (HP:0002032)1.61697103
123Cerebral inclusion bodies (HP:0100314)1.60140850
124Bell-shaped thorax (HP:0001591)1.58906630
125Abnormal urine output (HP:0012590)1.58652629
126Loss of speech (HP:0002371)1.58296764
127Easy fatigability (HP:0003388)1.55259823
128Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.54711644
129Absent epiphyses (HP:0010577)1.54711644
130Asymmetric septal hypertrophy (HP:0001670)1.54117400
131Aplasia/Hypoplasia of the lens (HP:0008063)1.53384288
132Oculomotor apraxia (HP:0000657)1.53032503
133Exercise-induced myalgia (HP:0003738)1.52266529
134Renal dysplasia (HP:0000110)1.52173782
135Short ribs (HP:0000773)1.51906208
136Myoglobinuria (HP:0002913)1.51034932
137Sensory axonal neuropathy (HP:0003390)1.50950470
138Bile duct proliferation (HP:0001408)1.50480777
139Abnormal biliary tract physiology (HP:0012439)1.50480777
140Bundle branch block (HP:0011710)1.46874318
141Cerebellar dysplasia (HP:0007033)1.44226476
142Generalized muscle weakness (HP:0003324)1.40408844
143Abnormality of the dental root (HP:0006486)1.39745500
144Taurodontia (HP:0000679)1.39745500
145Abnormality of permanent molar morphology (HP:0011071)1.39745500
146Short femoral neck (HP:0100864)1.38163548
147Postaxial hand polydactyly (HP:0001162)1.37461049
148Abnormality of dentin (HP:0010299)1.35394573
149Hypercholesterolemia (HP:0003124)1.33194670
150Polyuria (HP:0000103)1.32701486
151Rhabdomyolysis (HP:0003201)1.32499822
152Abnormality of the dental pulp (HP:0006479)1.31518244
153Difficulty climbing stairs (HP:0003551)1.29487536
154Hemiparesis (HP:0001269)1.29001038
155Deformed sella turcica (HP:0002681)1.27491228
156Abnormality of molar (HP:0011077)1.27442328
157Abnormality of molar morphology (HP:0011070)1.27442328
158Abnormality of saccadic eye movements (HP:0000570)1.27418119
159Abnormality of the lower motor neuron (HP:0002366)1.25706394
160Abnormal connection of the cardiac segments (HP:0011545)1.25645296
161Abnormal ventriculo-arterial connection (HP:0011563)1.25645296
162Transposition of the great arteries (HP:0001669)1.25645296
163Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.23604765
164Nephropathy (HP:0000112)1.23442722
165Retinal dysplasia (HP:0007973)1.22596412
166Decreased muscle mass (HP:0003199)1.22021803
167Bulbar palsy (HP:0001283)1.21919289
168Cleft eyelid (HP:0000625)1.21282857
169Facial cleft (HP:0002006)1.21004616

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK18.39609792
2PDK36.97681042
3PDK46.97681042
4PRKD35.50591854
5INSRR5.29849789
6ICK5.16219781
7BRD44.78788056
8PDK24.48256531
9PLK23.69094138
10PIK3CG2.55085359
11PTK2B2.46445057
12STK382.44301007
13MAP4K22.11710400
14WNK42.00086455
15STK391.96104531
16NEK21.87655923
17DDR21.71809116
18DYRK1B1.62688934
19PNCK1.45216160
20SIK21.40432619
21PDK11.35711526
22WNK31.21621907
23CAMK1D1.10379072
24TIE11.05997262
25BMPR1B1.04173090
26MST1R1.01486656
27PDPK11.00829700
28EEF2K1.00292296
29CDK120.97698335
30DYRK30.92308299
31IRAK10.90052052
32TYRO30.84874694
33NME10.82171593
34RIPK40.80619164
35MAP3K110.80560945
36MAPK150.78376492
37AKT30.77988983
38WNK10.71410022
39PASK0.70965043
40IRAK20.70296623
41PINK10.70237653
42UHMK10.69430577
43CAMK10.67850505
44TESK20.65505933
45SGK4940.62356912
46SGK2230.62356912
47ZAK0.61028568
48CCNB10.58779803
49MAP2K70.58255502
50TTK0.58114207
51STK30.57654053
52CDK30.57213178
53MUSK0.56061436
54CHEK20.55429733
55MAP3K90.54864790
56CDK70.53251291
57LATS10.51032336
58DYRK20.50480439
59NTRK30.50220726
60NTRK20.48129935
61TAOK30.44693095
62MOS0.44484671
63MAP2K60.43829819
64DMPK0.42681648
65PRKCG0.42229911
66LMTK20.39908534
67PAK10.39487715
68CAMK1G0.38016743
69PAK20.36250080
70MAP3K100.36056700
71LATS20.35926314
72MARK20.34264123
73MAPK10.33865483
74SGK20.33298602
75PAK40.31648796
76STK38L0.30830684
77RPS6KA20.30526434
78ROCK10.30065870
79CAMKK10.29913403
80SGK10.29426141
81MTOR0.27790970
82KSR20.26692376
83CHEK10.26361434
84MAPKAPK50.25647778
85MAP2K20.24959679
86PRKAA10.24638470
87PRKAA20.23210185
88PRKCZ0.22855275
89VRK10.22442870
90ATM0.21882961
91CSF1R0.21519906
92RPS6KB10.21081570
93CSNK1A10.20621565
94PKN20.18137929
95NEK60.17997698
96PRKCQ0.17580644
97ATR0.16104743
98AKT10.15500429
99MAP3K80.15282005
100MAPK100.14663557
101CDK150.14661920
102MAPK140.14567595
103RPS6KA10.13823940
104FLT30.13363994
105CDK50.12600816
106CDK180.12000386
107CAMK40.10930009
108PAK60.10764434
109CDK11A0.10384179
110TRIB30.10205254
111CLK10.10031586
112BRAF0.09731617
113PRKG20.08973408
114CDK140.07300652
115CAMK2A0.06483108
116GSK3B0.05597117
117PIM10.05335966
118MARK30.05302282
119CSNK2A10.05010457
120PLK10.04834891
121PKN10.04815073
122PRKCD0.04566717
123BRSK10.04528452
124STK110.04403856
125STK100.04281275
126PRKACG0.04048224
127BRSK20.02795882
128PRKCB0.02458310
129MAPK80.02392115
130PLK40.01957293
131CDK60.01620646
132PRKCA0.01124065
133CDK20.00175145
134PRKG10.00152357
135EPHB10.00045479
136MAP3K4-0.0687367
137CDK4-0.0624559
138MARK1-0.0585111
139SRC-0.0525930
140PRKACB-0.0504992
141PRKACA-0.0361156
142MAP3K1-0.0305545
143EGFR-0.0283574
144CSNK2A2-0.0248152
145MAP3K5-0.0221899
146RPS6KA3-0.0215663
147AURKA-0.0167069
148CDK1-0.0099881
149CSNK1D-0.0071384
150WEE1-0.0005989

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.19190477
2Fatty acid biosynthesis_Homo sapiens_hsa000614.87448778
3Olfactory transduction_Homo sapiens_hsa047404.09481064
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.08086915
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.42064487
6Linoleic acid metabolism_Homo sapiens_hsa005913.31429932
7Pyruvate metabolism_Homo sapiens_hsa006203.09195692
8Vitamin B6 metabolism_Homo sapiens_hsa007503.02644760
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.82376517
10Glucagon signaling pathway_Homo sapiens_hsa049222.52634432
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.48855689
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.39726510
13Propanoate metabolism_Homo sapiens_hsa006402.34334741
14Butanoate metabolism_Homo sapiens_hsa006502.31532266
15Selenocompound metabolism_Homo sapiens_hsa004502.13742879
16Glycerolipid metabolism_Homo sapiens_hsa005611.96552282
17PPAR signaling pathway_Homo sapiens_hsa033201.89468482
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.88990711
19Glycerophospholipid metabolism_Homo sapiens_hsa005641.86641588
20Basal transcription factors_Homo sapiens_hsa030221.82905827
21Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.81458062
22Fat digestion and absorption_Homo sapiens_hsa049751.80147262
23Amphetamine addiction_Homo sapiens_hsa050311.79257233
24Nicotine addiction_Homo sapiens_hsa050331.76966256
25Ether lipid metabolism_Homo sapiens_hsa005651.58824963
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.58244253
27Sulfur relay system_Homo sapiens_hsa041221.57737969
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54171647
29Fructose and mannose metabolism_Homo sapiens_hsa000511.53367157
30Cardiac muscle contraction_Homo sapiens_hsa042601.53151175
31Fatty acid degradation_Homo sapiens_hsa000711.52846471
32Fatty acid metabolism_Homo sapiens_hsa012121.52105673
33Oocyte meiosis_Homo sapiens_hsa041141.50256198
34Phenylalanine metabolism_Homo sapiens_hsa003601.44912081
35Morphine addiction_Homo sapiens_hsa050321.39300505
36Phototransduction_Homo sapiens_hsa047441.38928628
37Glutathione metabolism_Homo sapiens_hsa004801.38862514
38Mineral absorption_Homo sapiens_hsa049781.38039752
39Systemic lupus erythematosus_Homo sapiens_hsa053221.31839407
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29714718
41Carbon metabolism_Homo sapiens_hsa012001.25160581
42Pentose phosphate pathway_Homo sapiens_hsa000301.22856677
43Glutamatergic synapse_Homo sapiens_hsa047241.18046203
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.17442243
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16434466
46Renin secretion_Homo sapiens_hsa049241.08582238
47Dorso-ventral axis formation_Homo sapiens_hsa043201.06371816
48Hedgehog signaling pathway_Homo sapiens_hsa043401.05558882
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.02029203
50Collecting duct acid secretion_Homo sapiens_hsa049661.00995881
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98674784
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.98218665
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96934005
54Arginine biosynthesis_Homo sapiens_hsa002200.94521571
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92986446
56Antigen processing and presentation_Homo sapiens_hsa046120.92333008
57Insulin secretion_Homo sapiens_hsa049110.92243865
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91550388
59Nitrogen metabolism_Homo sapiens_hsa009100.91443016
60Long-term potentiation_Homo sapiens_hsa047200.89358781
61Arachidonic acid metabolism_Homo sapiens_hsa005900.88573514
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87846669
63Serotonergic synapse_Homo sapiens_hsa047260.87570730
64Alcoholism_Homo sapiens_hsa050340.86315605
65Fanconi anemia pathway_Homo sapiens_hsa034600.85754533
66Purine metabolism_Homo sapiens_hsa002300.84336145
67Base excision repair_Homo sapiens_hsa034100.83499941
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.81152087
69Huntingtons disease_Homo sapiens_hsa050160.81139023
70mRNA surveillance pathway_Homo sapiens_hsa030150.80440387
71Estrogen signaling pathway_Homo sapiens_hsa049150.79790690
72Thyroid hormone synthesis_Homo sapiens_hsa049180.78986064
73Bile secretion_Homo sapiens_hsa049760.78730604
74Chemical carcinogenesis_Homo sapiens_hsa052040.77288710
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76001678
76GABAergic synapse_Homo sapiens_hsa047270.74453282
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73777664
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73395050
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.66155717
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64351690
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62518530
82Biosynthesis of amino acids_Homo sapiens_hsa012300.58958779
83AMPK signaling pathway_Homo sapiens_hsa041520.56917706
84Tyrosine metabolism_Homo sapiens_hsa003500.56870330
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.56675608
86Pancreatic secretion_Homo sapiens_hsa049720.56596934
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56056452
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55776592
89Synaptic vesicle cycle_Homo sapiens_hsa047210.55704461
90Retinol metabolism_Homo sapiens_hsa008300.55591314
91Salivary secretion_Homo sapiens_hsa049700.54833785
92Arginine and proline metabolism_Homo sapiens_hsa003300.54807410
93Type I diabetes mellitus_Homo sapiens_hsa049400.53146351
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.52040747
95ABC transporters_Homo sapiens_hsa020100.50121815
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49459647
97Legionellosis_Homo sapiens_hsa051340.49293753
98Calcium signaling pathway_Homo sapiens_hsa040200.49066489
99RNA transport_Homo sapiens_hsa030130.47098257
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46893048
101Viral myocarditis_Homo sapiens_hsa054160.46748950
102Renin-angiotensin system_Homo sapiens_hsa046140.46277390
103Endocytosis_Homo sapiens_hsa041440.46133009
104Cocaine addiction_Homo sapiens_hsa050300.42898846
105Cholinergic synapse_Homo sapiens_hsa047250.42562624
106Gastric acid secretion_Homo sapiens_hsa049710.42473547
107beta-Alanine metabolism_Homo sapiens_hsa004100.41778267
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41681731
109Protein digestion and absorption_Homo sapiens_hsa049740.41364936
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40937265
111VEGF signaling pathway_Homo sapiens_hsa043700.40372076
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39534938
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39218861
114cAMP signaling pathway_Homo sapiens_hsa040240.38893274
115Influenza A_Homo sapiens_hsa051640.37866125
116Circadian entrainment_Homo sapiens_hsa047130.37180575
117Inositol phosphate metabolism_Homo sapiens_hsa005620.36338899
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32719017
119Metabolic pathways_Homo sapiens_hsa011000.32191929
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.32048603
121Gap junction_Homo sapiens_hsa045400.31587795
122Sulfur metabolism_Homo sapiens_hsa009200.30717021
123Nucleotide excision repair_Homo sapiens_hsa034200.30667090
124MAPK signaling pathway_Homo sapiens_hsa040100.30408442
125Oxytocin signaling pathway_Homo sapiens_hsa049210.30306657
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29485153
127RNA degradation_Homo sapiens_hsa030180.28759586
128Oxidative phosphorylation_Homo sapiens_hsa001900.24678974
129Taste transduction_Homo sapiens_hsa047420.24320687
130Insulin resistance_Homo sapiens_hsa049310.20872284
131Type II diabetes mellitus_Homo sapiens_hsa049300.19436651
132Viral carcinogenesis_Homo sapiens_hsa052030.18797078
133Salmonella infection_Homo sapiens_hsa051320.18693429
134HIF-1 signaling pathway_Homo sapiens_hsa040660.18509063
135B cell receptor signaling pathway_Homo sapiens_hsa046620.18235466
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15488659
137Pyrimidine metabolism_Homo sapiens_hsa002400.15159051
138Aldosterone synthesis and secretion_Homo sapiens_hsa049250.14908802
139Basal cell carcinoma_Homo sapiens_hsa052170.14611771
140Dopaminergic synapse_Homo sapiens_hsa047280.11104404

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