ZP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.60568757
2positive regulation of humoral immune response (GO:0002922)8.52170996
3positive regulation of inflammatory response to antigenic stimulus (GO:0002863)8.32517489
4protein localization to kinetochore (GO:0034501)8.00803072
5regulation of phospholipid biosynthetic process (GO:0071071)7.85184248
6regulation of acute inflammatory response to antigenic stimulus (GO:0002864)7.30533215
7protein kinase C signaling (GO:0070528)7.29578022
8DNA methylation involved in gamete generation (GO:0043046)7.25680257
9citrulline biosynthetic process (GO:0019240)7.19641885
10oocyte development (GO:0048599)7.00789221
11regulation of retinoic acid receptor signaling pathway (GO:0048385)6.86810067
12immunoglobulin mediated immune response (GO:0016064)6.71735358
13female gamete generation (GO:0007292)6.57057906
14* multicellular organism reproduction (GO:0032504)6.55988277
15protein localization to chromosome, centromeric region (GO:0071459)6.43925299
16mitotic metaphase plate congression (GO:0007080)6.20980894
17negative regulation of reproductive process (GO:2000242)6.18487237
18mitotic chromosome condensation (GO:0007076)6.05808702
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.73853870
20regulation of histone H3-K9 methylation (GO:0051570)5.49818938
21regulation of steroid hormone secretion (GO:2000831)5.44550715
22positive regulation of histone H3-K4 methylation (GO:0051571)5.42895647
23regulation of meiosis (GO:0040020)5.23347714
24metaphase plate congression (GO:0051310)5.13711268
25* sperm-egg recognition (GO:0035036)5.07990561
26* reproduction (GO:0000003)4.95996914
27B cell mediated immunity (GO:0019724)4.94811977
28endothelium development (GO:0003158)4.92506367
29negative regulation of meiosis (GO:0045835)4.83240904
30oogenesis (GO:0048477)4.70686050
31protein localization to chromosome (GO:0034502)4.67558164
32positive regulation of interleukin-4 production (GO:0032753)4.60037503
33meiotic cell cycle (GO:0051321)4.50214881
34establishment of chromosome localization (GO:0051303)4.47233798
35notochord development (GO:0030903)4.44944671
36positive regulation of calcium ion import (GO:0090280)4.44479212
37mitotic sister chromatid segregation (GO:0000070)4.44052632
38protein K6-linked ubiquitination (GO:0085020)4.39908678
39citrulline metabolic process (GO:0000052)4.38685301
40male meiosis (GO:0007140)4.37954173
41histone H2A ubiquitination (GO:0033522)4.35492963
42negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.31233535
43base-excision repair, AP site formation (GO:0006285)4.23214904
44attachment of spindle microtubules to kinetochore (GO:0008608)4.23056693
45oocyte maturation (GO:0001556)4.21810574
46retinal cone cell development (GO:0046549)4.20265960
47spindle checkpoint (GO:0031577)4.19398205
48DNA methylation (GO:0006306)4.18220258
49DNA alkylation (GO:0006305)4.18220258
50regulation of DNA methylation (GO:0044030)4.17785834
51regulation of exit from mitosis (GO:0007096)4.14866857
52regulation of calcium ion-dependent exocytosis (GO:0017158)4.12418525
53* fertilization (GO:0009566)4.11733886
54regulation of meiotic cell cycle (GO:0051445)4.09680023
55* cell-cell recognition (GO:0009988)4.09310715
56negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.03570953
57negative regulation of DNA-templated transcription, elongation (GO:0032785)4.03570953
58histone H2A monoubiquitination (GO:0035518)3.96591363
59peptidyl-arginine modification (GO:0018195)3.95164443
60negative regulation of chromosome segregation (GO:0051985)3.91516793
61gene silencing by RNA (GO:0031047)3.90428349
62microtubule severing (GO:0051013)3.88487178
63negative regulation of mitotic sister chromatid separation (GO:2000816)3.87660597
64negative regulation of mitotic sister chromatid segregation (GO:0033048)3.87660597
65negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.87660597
66negative regulation of sister chromatid segregation (GO:0033046)3.87660597
67positive regulation of chromosome segregation (GO:0051984)3.87577179
68pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.87414174
69regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.86508161
70positive regulation of reproductive process (GO:2000243)3.84032248
71mitotic spindle assembly checkpoint (GO:0007094)3.79888083
72regulation of reproductive process (GO:2000241)3.78538564
73regulation of sister chromatid cohesion (GO:0007063)3.78517988
74mitotic spindle checkpoint (GO:0071174)3.75637101
75negative regulation of meiotic cell cycle (GO:0051447)3.74829330
76glycine transport (GO:0015816)3.74626738
77spindle assembly checkpoint (GO:0071173)3.68411162
78positive regulation of interleukin-1 beta secretion (GO:0050718)3.66447001
79regulation of chromosome segregation (GO:0051983)3.62991771
80regulation of spindle organization (GO:0090224)3.62069738
81* single fertilization (GO:0007338)3.60938905
82sister chromatid segregation (GO:0000819)3.60261399
83regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.59304983
84ovarian follicle development (GO:0001541)3.56694015
85regulation of steroid hormone biosynthetic process (GO:0090030)3.53308886
86positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.53062832
87positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.53062832
88positive regulation of mitotic sister chromatid separation (GO:1901970)3.53062832
89* binding of sperm to zona pellucida (GO:0007339)3.52701256
90phosphatidylinositol dephosphorylation (GO:0046856)3.52455599
91regulation of mitotic metaphase/anaphase transition (GO:0030071)3.52028340
92negative regulation of smooth muscle cell differentiation (GO:0051151)3.50819597
93interkinetic nuclear migration (GO:0022027)3.50530406
94regulation of sister chromatid segregation (GO:0033045)3.49762360
95regulation of mitotic sister chromatid separation (GO:0010965)3.49762360
96regulation of mitotic sister chromatid segregation (GO:0033047)3.49762360
97regulation of chromatin silencing (GO:0031935)3.49266068
98regulation of mitotic spindle organization (GO:0060236)3.46938288
99regulation of inflammatory response to antigenic stimulus (GO:0002861)3.45280762
100negative regulation of nuclear division (GO:0051784)3.43844425
101regulation of histone H3-K4 methylation (GO:0051569)3.43744982
102N-terminal protein amino acid acetylation (GO:0006474)3.43175769
103histone H3-K4 trimethylation (GO:0080182)3.42984968
104positive regulation of interleukin-1 secretion (GO:0050716)3.39528465
105negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.35249263
106regulation of meiosis I (GO:0060631)3.34354224
107positive regulation of interleukin-1 beta production (GO:0032731)3.32485934
108regulation of interleukin-4 production (GO:0032673)3.29538489
109phospholipid dephosphorylation (GO:0046839)3.28698368
110stress granule assembly (GO:0034063)3.28257620
111negative regulation of mitosis (GO:0045839)3.27619967
112negative regulation of histone methylation (GO:0031061)3.27297678
113negative regulation of cell division (GO:0051782)3.26528977
114positive regulation of histone methylation (GO:0031062)3.25861291
115regulation of transforming growth factor beta2 production (GO:0032909)3.24004842
116positive regulation of endothelial cell differentiation (GO:0045603)3.23145748
117phosphorelay signal transduction system (GO:0000160)3.06966567
118regulation of cell maturation (GO:1903429)3.05681251
119gene silencing (GO:0016458)3.05225528
120regulation of spindle checkpoint (GO:0090231)2.99580381
121positive regulation of uterine smooth muscle contraction (GO:0070474)2.98579008
122histone H3-K4 methylation (GO:0051568)2.97616759
123centriole replication (GO:0007099)2.89707432
124DNA methylation or demethylation (GO:0044728)2.89509092
125regulation of histone methylation (GO:0031060)2.88231109
126regulation of chromatin binding (GO:0035561)2.87157375
127regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.85925732
128histone H3-K9 demethylation (GO:0033169)2.85156725
129positive regulation of exocytosis (GO:0045921)2.84402574
130DNA replication checkpoint (GO:0000076)2.80513815
131regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.79046570
132negative regulation of cAMP-mediated signaling (GO:0043951)2.77567134
133positive regulation of gastrulation (GO:2000543)2.74281801
134positive regulation of hormone biosynthetic process (GO:0046886)2.71276721
135positive regulation of gene expression, epigenetic (GO:0045815)2.70792267
136negative regulation of organelle assembly (GO:1902116)2.68457964
137type B pancreatic cell development (GO:0003323)2.67671388
138histone lysine demethylation (GO:0070076)2.65635709
139regulation of corticosteroid hormone secretion (GO:2000846)2.65554126
140synapsis (GO:0007129)2.61782296
141male meiosis I (GO:0007141)2.61233329
142phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.59481968
143germ cell development (GO:0007281)2.58561773
144synaptonemal complex assembly (GO:0007130)2.58233842
145negative regulation of histone modification (GO:0031057)2.56007941
146primitive streak formation (GO:0090009)2.54061889
147negative regulation of gene silencing (GO:0060969)2.53627643
148regulation of humoral immune response (GO:0002920)2.53149489
149histone demethylation (GO:0016577)2.52599297
150regulation of cell cycle G2/M phase transition (GO:1902749)2.52576162
151regulation of female gonad development (GO:2000194)15.6355623
152regulation of acrosome reaction (GO:0060046)11.4115809
153regulation of hypersensitivity (GO:0002883)10.8203964

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.83234200
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.63899222
3E2F7_22180533_ChIP-Seq_HELA_Human4.88597175
4AR_21909140_ChIP-Seq_LNCAP_Human4.47244723
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.42627943
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.89328825
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.61869403
8NOTCH1_21737748_ChIP-Seq_TLL_Human3.35246162
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.24896298
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.99019483
11KAP1_22055183_ChIP-Seq_ESCs_Mouse2.94359161
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.40953470
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.18684960
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15309315
15MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse2.00190339
16GATA1_26923725_Chip-Seq_HPCs_Mouse1.98108395
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93350384
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.73257165
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.73257165
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.73257165
21MYC_18940864_ChIP-ChIP_HL60_Human1.72954624
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70615714
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.67925358
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62899040
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.62086569
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.61583587
27HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.58634132
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58437190
29GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.56063368
30GATA3_21867929_ChIP-Seq_TH1_Mouse1.54567619
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.47731157
32TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.46716521
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42152604
34CDX2_22108803_ChIP-Seq_LS180_Human1.39444002
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.36881030
36STAT1_20625510_ChIP-Seq_HELA_Human1.36754421
37RNF2_27304074_Chip-Seq_NSC_Mouse1.34588509
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31982552
39NANOG_21062744_ChIP-ChIP_HESCs_Human1.30423573
40MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.28807146
41AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25219069
42* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24841300
43NFYA_21822215_ChIP-Seq_K562_Human1.24117858
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24052072
45CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23651892
46EP300_21415370_ChIP-Seq_HL-1_Mouse1.22496885
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22450093
48STAT1_17558387_ChIP-Seq_HELA_Human1.21227553
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20586602
50KLF4_19829295_ChIP-Seq_ESCs_Human1.20266182
51* ESET_19884257_ChIP-Seq_ESCs_Mouse1.17558985
52RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15171076
53FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12664761
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10384320
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09167109
56ETV1_20927104_ChIP-Seq_GIST48_Human1.08701425
57GBX2_23144817_ChIP-Seq_PC3_Human1.07302972
58GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07162519
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06440480
60GATA1_19941827_ChIP-Seq_MEL86_Mouse1.06413388
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06183607
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05628681
63NANOG_20526341_ChIP-Seq_ESCs_Human1.04988752
64AR_21572438_ChIP-Seq_LNCaP_Human1.04167627
65CBX2_22325352_ChIP-Seq_293T-Rex_Human1.03564658
66SPI1_26923725_Chip-Seq_HPCs_Mouse1.02535331
67STAT3_23295773_ChIP-Seq_U87_Human1.02485686
68NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.01462018
69TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01248698
70HNFA_21074721_ChIP-Seq_CACO-2_Human1.01095803
71CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00514958
72MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98642701
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97589358
74IGF1R_20145208_ChIP-Seq_DFB_Human0.96702102
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96185139
76TBL1_22424771_ChIP-Seq_293T_Human0.96119518
77FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96027787
78EWS_26573619_Chip-Seq_HEK293_Human0.94058602
79KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93167227
80SMAD4_21741376_ChIP-Seq_EPCs_Human0.92166803
81FOXH1_21741376_ChIP-Seq_EPCs_Human0.92071131
82KDM2B_26808549_Chip-Seq_REH_Human0.91851872
83ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.91264531
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91085400
85SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.90459233
86CTCF_18555785_Chip-Seq_ESCs_Mouse0.90348026
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89523410
88OCT4_19829295_ChIP-Seq_ESCs_Human0.89286731
89FOXO3_23340844_ChIP-Seq_DLD1_Human0.88291862
90P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.87334935
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87036500
92GF1B_26923725_Chip-Seq_HPCs_Mouse0.86305563
93FLI1_27457419_Chip-Seq_LIVER_Mouse0.86079804
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85642336
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85630671
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.85561907
97TCF4_23295773_ChIP-Seq_U87_Human0.85485265
98SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84803332
99TP53_22573176_ChIP-Seq_HFKS_Human0.83817904
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.83360692
101TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83322171
102PHF8_20622853_ChIP-Seq_HELA_Human0.83266339
103RBPJ_21746931_ChIP-Seq_IB4_Human0.83202078
104GATA6_21074721_ChIP-Seq_CACO-2_Human0.82696889
105CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.82660978
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82575365
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82575365
108ELK4_26923725_Chip-Seq_MESODERM_Mouse0.82550123
109GATA3_26560356_Chip-Seq_TH1_Human0.82202773
110* BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.81315425
111RUNX2_22187159_ChIP-Seq_PCA_Human0.81078216
112TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.81045150
113ERG_20517297_ChIP-Seq_VCAP_Human0.80615468
114TP63_23658742_ChIP-Seq_EP156T_Human0.80245098
115P68_20966046_ChIP-Seq_HELA_Human0.79738160
116SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79421146
117CBP_20019798_ChIP-Seq_JUKART_Human0.79296600
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79296600
119RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78420531
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.78359674
121PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78107618
122ESR1_21235772_ChIP-Seq_MCF-7_Human0.77928364
123NFYB_21822215_ChIP-Seq_K562_Human0.77796105
124LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77769380
125PRDM14_20953172_ChIP-Seq_ESCs_Human0.77578000
126TET1_21490601_ChIP-Seq_MESCs_Mouse0.77329509
127NFE2_27457419_Chip-Seq_LIVER_Mouse0.77243444
128KLF4_18555785_Chip-Seq_ESCs_Mouse0.76940999
129TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76639769
130STAT3_18555785_Chip-Seq_ESCs_Mouse0.76614130
131ESRRB_18555785_Chip-Seq_ESCs_Mouse0.76323257
132GATA3_21878914_ChIP-Seq_MCF-7_Human0.76115023
133AR_25329375_ChIP-Seq_VCAP_Human0.75166096
134TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.72976475
135RXR_22108803_ChIP-Seq_LS180_Human0.72062353
136SMRT_27268052_Chip-Seq_Bcells_Human0.71371270
137PKCTHETA_26484144_Chip-Seq_BREAST_Human0.70646431
138BCOR_27268052_Chip-Seq_Bcells_Human0.69486496
139GF1_26923725_Chip-Seq_HPCs_Mouse0.67649797
140EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.67419255
141SMAD3_21741376_ChIP-Seq_ESCs_Human0.67395376
142UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.66214679
143ESR1_15608294_ChIP-ChIP_MCF-7_Human0.66036021
144LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.65399264
145SMAD4_21799915_ChIP-Seq_A2780_Human0.64044863
146CBP_21632823_ChIP-Seq_H3396_Human0.63881309
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.61844770
148* SMAD3_21741376_ChIP-Seq_EPCs_Human0.60222586
149OCT4_20526341_ChIP-Seq_ESCs_Human0.59609817
150NCOR_22424771_ChIP-Seq_293T_Human0.59588847
151SALL4_22934838_ChIP-ChIP_CD34+_Human0.56515932
152MYC_19829295_ChIP-Seq_ESCs_Human0.56200588
153PHF8_20622854_ChIP-Seq_HELA_Human0.55824903
154CTCF_21964334_Chip-Seq_Bcells_Human0.55785141
155SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.55513136
156SMAD4_21741376_ChIP-Seq_ESCs_Human0.54355529
157CTCF_20526341_ChIP-Seq_ESCs_Human0.54157498
158TAF2_19829295_ChIP-Seq_ESCs_Human0.52942154
159CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.52742020
160SMC1_22415368_ChIP-Seq_MEFs_Mouse0.52384304
161SRY_22984422_ChIP-ChIP_TESTIS_Rat0.52303914
162FOXP3_21729870_ChIP-Seq_TREG_Human0.52092378
163VDR_22108803_ChIP-Seq_LS180_Human0.51607762
164GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.51532016
165RAD21_21589869_ChIP-Seq_MESCs_Mouse0.50769739
166IRF1_19129219_ChIP-ChIP_H3396_Human0.49957299
167PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.49494893
168YY1_21170310_ChIP-Seq_MESCs_Mouse0.49465578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect8.32404622
2MP0008877_abnormal_DNA_methylation5.11439111
3MP0010094_abnormal_chromosome_stability4.20679267
4MP0003646_muscle_fatigue4.15987243
5MP0005451_abnormal_body_composition3.74614993
6MP0003693_abnormal_embryo_hatching3.69910963
7MP0005395_other_phenotype3.58456445
8* MP0003699_abnormal_female_reproductive3.55060473
9MP0002295_abnormal_pulmonary_circulatio3.31652354
10* MP0001119_abnormal_female_reproductive3.25910125
11MP0003077_abnormal_cell_cycle2.98636147
12MP0003111_abnormal_nucleus_morphology2.94403295
13MP0008057_abnormal_DNA_replication2.93516256
14MP0002139_abnormal_hepatobiliary_system2.91209707
15* MP0001929_abnormal_gametogenesis2.88417672
16MP0008789_abnormal_olfactory_epithelium2.78761722
17MP0000579_abnormal_nail_morphology2.59678429
18MP0002138_abnormal_hepatobiliary_system2.51132105
19MP0005499_abnormal_olfactory_system2.49417163
20MP0005394_taste/olfaction_phenotype2.49417163
21MP0004859_abnormal_synaptic_plasticity2.48502137
22* MP0000653_abnormal_sex_gland2.43512927
23MP0004957_abnormal_blastocyst_morpholog2.39121659
24MP0006072_abnormal_retinal_apoptosis2.38685490
25MP0001905_abnormal_dopamine_level2.28834149
26MP0002210_abnormal_sex_determination2.20025716
27MP0001986_abnormal_taste_sensitivity2.16021756
28MP0003121_genomic_imprinting2.09672563
29* MP0002161_abnormal_fertility/fecundity1.96679887
30MP0003329_amyloid_beta_deposits1.94408480
31MP0003879_abnormal_hair_cell1.90480558
32MP0000465_gastrointestinal_hemorrhage1.85417547
33MP0005410_abnormal_fertilization1.84163698
34MP0005360_urolithiasis1.84084203
35MP0003252_abnormal_bile_duct1.64329974
36MP0009384_cardiac_valve_regurgitation1.63020687
37MP0008932_abnormal_embryonic_tissue1.59367286
38MP0003890_abnormal_embryonic-extraembry1.56003744
39MP0010307_abnormal_tumor_latency1.54461723
40MP0002102_abnormal_ear_morphology1.53532858
41MP0001529_abnormal_vocalization1.51854067
42MP0010030_abnormal_orbit_morphology1.51012827
43MP0001915_intracranial_hemorrhage1.50382858
44MP0003123_paternal_imprinting1.47348014
45MP0002932_abnormal_joint_morphology1.42216143
46MP0002249_abnormal_larynx_morphology1.41411792
47MP0003315_abnormal_perineum_morphology1.35390210
48MP0002653_abnormal_ependyma_morphology1.33797622
49MP0001145_abnormal_male_reproductive1.32420799
50MP0003950_abnormal_plasma_membrane1.31946543
51MP0003937_abnormal_limbs/digits/tail_de1.29566291
52MP0001730_embryonic_growth_arrest1.27311454
53MP0000350_abnormal_cell_proliferation1.22620768
54MP0000566_synostosis1.20563933
55MP0003959_abnormal_lean_body1.17844606
56MP0004142_abnormal_muscle_tone1.13691106
57MP0005646_abnormal_pituitary_gland1.13129038
58MP0003880_abnormal_central_pattern1.12854280
59MP0005647_abnormal_sex_gland1.12746462
60MP0001664_abnormal_digestion1.12079935
61MP0000003_abnormal_adipose_tissue1.11244160
62MP0001485_abnormal_pinna_reflex1.08463886
63MP0005197_abnormal_uvea_morphology1.08428152
64MP0001672_abnormal_embryogenesis/_devel1.06247192
65MP0005380_embryogenesis_phenotype1.06247192
66MP0008260_abnormal_autophagy1.05872284
67MP0006292_abnormal_olfactory_placode1.05451801
68MP0002019_abnormal_tumor_incidence1.04736909
69MP0005408_hypopigmentation1.03461631
70MP0000013_abnormal_adipose_tissue0.99149649
71MP0002160_abnormal_reproductive_system0.99055617
72MP0000604_amyloidosis0.98037594
73MP0003453_abnormal_keratinocyte_physiol0.96612617
74MP0001666_abnormal_nutrient_absorption0.96294685
75MP0002085_abnormal_embryonic_tissue0.94350518
76MP0002933_joint_inflammation0.92925933
77MP0005076_abnormal_cell_differentiation0.91665566
78MP0003787_abnormal_imprinting0.90068967
79MP0000631_abnormal_neuroendocrine_gland0.89962144
80MP0004264_abnormal_extraembryonic_tissu0.88569133
81MP0002089_abnormal_postnatal_growth/wei0.87656851
82MP0002177_abnormal_outer_ear0.87395469
83MP0006276_abnormal_autonomic_nervous0.87379801
84MP0003656_abnormal_erythrocyte_physiolo0.86109594
85MP0000762_abnormal_tongue_morphology0.85178490
86MP0003119_abnormal_digestive_system0.84114900
87MP0003183_abnormal_peptide_metabolism0.83427063
88MP0003698_abnormal_male_reproductive0.80737870
89MP0010386_abnormal_urinary_bladder0.80671415
90MP0005187_abnormal_penis_morphology0.80055025
91MP0002108_abnormal_muscle_morphology0.79645473
92MP0002282_abnormal_trachea_morphology0.78877449
93MP0003806_abnormal_nucleotide_metabolis0.78138923
94MP0003786_premature_aging0.77402880
95MP0003763_abnormal_thymus_physiology0.77129471
96MP0001697_abnormal_embryo_size0.76797730
97MP0001545_abnormal_hematopoietic_system0.76280145
98MP0005397_hematopoietic_system_phenotyp0.76280145
99MP0005257_abnormal_intraocular_pressure0.73291567
100MP0002272_abnormal_nervous_system0.73009826
101MP0001502_abnormal_circadian_rhythm0.72867870
102MP0005023_abnormal_wound_healing0.71771052
103MP0001324_abnormal_eye_pigmentation0.71217159
104MP0010368_abnormal_lymphatic_system0.69824379
105MP0003075_altered_response_to0.69323268
106MP0009840_abnormal_foam_cell0.68570196
107MP0001984_abnormal_olfaction0.68392724
108MP0002084_abnormal_developmental_patter0.68238843
109MP0000678_abnormal_parathyroid_gland0.68230291
110MP0005621_abnormal_cell_physiology0.67866523
111MP0000639_abnormal_adrenal_gland0.67529314
112MP0002234_abnormal_pharynx_morphology0.67067126
113MP0002928_abnormal_bile_duct0.65916651
114MP0000733_abnormal_muscle_development0.65042385
115MP0002233_abnormal_nose_morphology0.64290284
116MP0005409_darkened_coat_color0.64129233
117MP0002269_muscular_atrophy0.64070544
118MP0009697_abnormal_copulation0.62863976
119MP0002098_abnormal_vibrissa_morphology0.62226711
120MP0005551_abnormal_eye_electrophysiolog0.61779802
121MP0004484_altered_response_of0.60837211
122MP0005085_abnormal_gallbladder_physiolo0.60637578
123MP0005645_abnormal_hypothalamus_physiol0.60452962
124MP0010234_abnormal_vibrissa_follicle0.60413589
125MP0004510_myositis0.60224381
126MP0000313_abnormal_cell_death0.59801216
127MP0006138_congestive_heart_failure0.59488148
128MP0001293_anophthalmia0.59254468
129MP0010678_abnormal_skin_adnexa0.56119898
130MP0005310_abnormal_salivary_gland0.55807340
131MP0005384_cellular_phenotype0.54677592
132MP0003705_abnormal_hypodermis_morpholog0.54666819
133MP0003868_abnormal_feces_composition0.54626140
134MP0001944_abnormal_pancreas_morphology0.53812948
135MP0005319_abnormal_enzyme/_coenzyme0.53441218
136MP0008007_abnormal_cellular_replicative0.53069580
137MP0001346_abnormal_lacrimal_gland0.52096324
138MP0008875_abnormal_xenobiotic_pharmacok0.50947273
139MP0004185_abnormal_adipocyte_glucose0.50686892
140MP0000383_abnormal_hair_follicle0.49423713
141MP0004782_abnormal_surfactant_physiolog0.49014638
142MP0008058_abnormal_DNA_repair0.48537003
143MP0003632_abnormal_nervous_system0.48189897
144MP0000462_abnormal_digestive_system0.47701371
145MP0002080_prenatal_lethality0.47468611
146MP0000427_abnormal_hair_cycle0.47082818
147MP0001849_ear_inflammation0.45469200
148MP0002396_abnormal_hematopoietic_system0.44424496
149MP0004233_abnormal_muscle_weight0.43874968
150MP0003984_embryonic_growth_retardation0.43540555
151MP0002163_abnormal_gland_morphology0.42928216
152MP0000613_abnormal_salivary_gland0.42371136
153MP0002837_dystrophic_cardiac_calcinosis0.40435328
154MP0000490_abnormal_crypts_of0.39276685
155MP0000627_abnormal_mammary_gland0.38833353
156MP0002088_abnormal_embryonic_growth/wei0.38768550
157MP0000015_abnormal_ear_pigmentation0.38344876
158MP0004270_analgesia0.38339611
159* MP0005389_reproductive_system_phenotype0.37341585

Predicted human phenotypes

RankGene SetZ-score
1Premature ovarian failure (HP:0008209)8.54400516
2Deep venous thrombosis (HP:0002625)8.19811702
3Male infertility (HP:0003251)6.11095982
4Cortical dysplasia (HP:0002539)5.39183779
5Rhabdomyosarcoma (HP:0002859)4.90226825
6Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.78288657
7Secondary amenorrhea (HP:0000869)4.78274248
8Combined immunodeficiency (HP:0005387)4.61799770
9Aplasia/Hypoplasia of the macula (HP:0008059)4.54024882
10Chromsome breakage (HP:0040012)4.49330330
11Abdominal situs inversus (HP:0003363)4.46864974
12Abnormality of abdominal situs (HP:0011620)4.46864974
13Aplasia/Hypoplasia of the sternum (HP:0006714)4.40263606
14Birth length less than 3rd percentile (HP:0003561)4.36163415
15Aplasia/Hypoplasia affecting the retina (HP:0008061)4.22161908
16Abnormality of chromosome segregation (HP:0002916)4.17049229
17Hypergonadotropic hypogonadism (HP:0000815)4.04184669
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.99349896
19Breast hypoplasia (HP:0003187)3.85901637
20Lip pit (HP:0100267)3.83940870
21Abnormality of the labia minora (HP:0012880)3.83057163
22Osteomalacia (HP:0002749)3.67612594
23Flat capital femoral epiphysis (HP:0003370)3.66867895
24Impulsivity (HP:0100710)3.63413669
25Hypophosphatemic rickets (HP:0004912)3.51190132
26Abnormal lung lobation (HP:0002101)3.48557966
27Patellar aplasia (HP:0006443)3.41489293
28Neoplasm of striated muscle (HP:0009728)3.38396523
29Carpal bone hypoplasia (HP:0001498)3.34788170
30Pulmonary fibrosis (HP:0002206)3.27169582
31Abnormality of the proximal phalanges of the hand (HP:0009834)3.25901053
32Abnormality of the anterior chamber (HP:0000593)3.23314305
33Nephroblastoma (Wilms tumor) (HP:0002667)3.17332654
34Arterial tortuosity (HP:0005116)3.10932929
35Aplasia/Hypoplasia of the patella (HP:0006498)3.10035184
36Abnormal gallbladder physiology (HP:0012438)3.07324227
37Cholecystitis (HP:0001082)3.07324227
38Azoospermia (HP:0000027)3.06453831
39Duodenal stenosis (HP:0100867)3.01274578
40Small intestinal stenosis (HP:0012848)3.01274578
41Embryonal renal neoplasm (HP:0011794)2.95514828
42Facial hemangioma (HP:0000329)2.95116596
43Aplasia of the musculature (HP:0100854)2.93129613
44Fetal akinesia sequence (HP:0001989)2.90181271
45Aplasia/Hypoplasia involving the musculature (HP:0001460)2.79809856
46Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.79124915
47Amniotic constriction ring (HP:0009775)2.78406235
48Abnormality of placental membranes (HP:0011409)2.78406235
49Leiomyosarcoma (HP:0100243)2.77345781
50Uterine leiomyosarcoma (HP:0002891)2.77345781
51Adrenal hypoplasia (HP:0000835)2.75784160
52Anhidrosis (HP:0000970)2.72351636
53Prostate neoplasm (HP:0100787)2.69611484
54Vascular tortuosity (HP:0004948)2.67434354
55* Infertility (HP:0000789)2.64984253
56Aplasia/Hypoplasia of the breasts (HP:0010311)2.58050711
57Shawl scrotum (HP:0000049)2.55772963
58Poikiloderma (HP:0001029)2.55462531
59Apathy (HP:0000741)2.54793133
60Papillary thyroid carcinoma (HP:0002895)2.54217357
61Bundle branch block (HP:0011710)2.51016159
62Aplasia/Hypoplasia of the fovea (HP:0008060)2.47781777
63Hypoplasia of the fovea (HP:0007750)2.47781777
64Septo-optic dysplasia (HP:0100842)2.46111684
65Breast aplasia (HP:0100783)2.46063796
66Abnormality of carpal bone ossification (HP:0006257)2.38653639
67Primary amenorrhea (HP:0000786)2.38095913
68Hypoplasia of the capital femoral epiphysis (HP:0003090)2.37741087
69Sloping forehead (HP:0000340)2.37658614
70Metaphyseal irregularity (HP:0003025)2.35153143
71Thyroid carcinoma (HP:0002890)2.34723690
72Abnormality of the fovea (HP:0000493)2.34005990
73Atelectasis (HP:0100750)2.33996317
74Oligodactyly (hands) (HP:0001180)2.32481159
75Posterior embryotoxon (HP:0000627)2.32394126
76Diminished motivation (HP:0000745)2.30360389
77Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.30225726
78Transitional cell carcinoma of the bladder (HP:0006740)2.29716559
79Abnormal spermatogenesis (HP:0008669)2.29478336
80Abnormality of the duodenum (HP:0002246)2.29200069
81Malnutrition (HP:0004395)2.28497220
82Anterior segment dysgenesis (HP:0007700)2.25964502
83Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.25608156
84Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.25513776
85Increased nuchal translucency (HP:0010880)2.25364933
86Wrist flexion contracture (HP:0001239)2.24850111
87Abnormality of small intestinal villus morphology (HP:0011472)2.24236524
88Villous atrophy (HP:0011473)2.24236524
89Spondylolisthesis (HP:0003302)2.23542985
90Supernumerary spleens (HP:0009799)2.21323194
91Abnormality of the line of Schwalbe (HP:0008048)2.19180874
92Maternal diabetes (HP:0009800)2.18988753
93Irregular epiphyses (HP:0010582)2.18202957
94Bladder neoplasm (HP:0009725)2.17944246
95Bladder carcinoma (HP:0002862)2.17944246
96Hypokinesia (HP:0002375)2.15882018
97Sandal gap (HP:0001852)2.14685673
98Truncal obesity (HP:0001956)2.14090707
99Insulin-resistant diabetes mellitus (HP:0000831)2.13324623
100Neurofibrillary tangles (HP:0002185)2.10111256
101Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.10015594
102Absent radius (HP:0003974)2.08740089
103Gonadotropin excess (HP:0000837)2.08136172
104Loss of speech (HP:0002371)2.07963004
105Supranuclear gaze palsy (HP:0000605)2.05789598
106Abnormality of cochlea (HP:0000375)2.05463975
107Myokymia (HP:0002411)2.05398495
108Capillary hemangiomas (HP:0005306)2.04977352
109Anteriorly placed anus (HP:0001545)2.03857636
110Abnormality of chromosome stability (HP:0003220)2.02889379
111Elevated alkaline phosphatase (HP:0003155)2.02243937
112Aplasia involving forearm bones (HP:0009822)2.01138228
113Absent forearm bone (HP:0003953)2.01138228
114Cone-rod dystrophy (HP:0000548)2.00868465
115Urethral obstruction (HP:0000796)2.00538929
116Toxemia of pregnancy (HP:0100603)2.00304433
117Renovascular hypertension (HP:0100817)2.00062377
118IgG deficiency (HP:0004315)1.98883804
119Myelodysplasia (HP:0002863)1.98099593
120Fibular aplasia (HP:0002990)1.97763873
121Abnormality of the epiphysis of the femoral head (HP:0010574)1.97739511
122Aplasia involving bones of the extremities (HP:0009825)1.95808784
123Aplasia involving bones of the upper limbs (HP:0009823)1.95808784
124Aplasia of the phalanges of the hand (HP:0009802)1.95808784
125Oligodactyly (HP:0012165)1.94473710
126Absent septum pellucidum (HP:0001331)1.94293963
127Hypoalphalipoproteinemia (HP:0003233)1.93559195
128Sensory axonal neuropathy (HP:0003390)1.92711888
129Dysdiadochokinesis (HP:0002075)1.92129322
130Progressive sensorineural hearing impairment (HP:0000408)1.91149323
131Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.89912092
132Aplasia/Hypoplasia of the uvula (HP:0010293)1.89024058
133Reduced subcutaneous adipose tissue (HP:0003758)1.88561833
134Increased circulating renin level (HP:0000848)1.87790932
135Spinal cord compression (HP:0002176)1.87647380
136Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87338328
137Abnormality of alanine metabolism (HP:0010916)1.87338328
138Hyperalaninemia (HP:0003348)1.87338328
139Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86786893
140Gastrointestinal carcinoma (HP:0002672)1.86612543
141Malignant gastrointestinal tract tumors (HP:0006749)1.86612543
142Short 1st metacarpal (HP:0010034)1.86235644
143Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.86235644
144Embryonal neoplasm (HP:0002898)1.85433781
145Non-midline cleft lip (HP:0100335)1.85109395
146Neoplasm of the colon (HP:0100273)1.84230704
147Entropion (HP:0000621)1.81987601
148Decreased circulating renin level (HP:0003351)1.81936676
149Abnormality of alkaline phosphatase activity (HP:0004379)1.81745045
150Poor speech (HP:0002465)1.80937481
151Congenital sensorineural hearing impairment (HP:0008527)1.80925255
152Type 2 muscle fiber atrophy (HP:0003554)1.80743057
153Skin pits (HP:0100276)1.80553040
154Obstructive sleep apnea (HP:0002870)1.80486786
155Abnormality of the femoral head (HP:0003368)1.78364040
156Short thumb (HP:0009778)1.78234706
157Sparse eyelashes (HP:0000653)1.77957751
158Abnormal hand bone ossification (HP:0010660)1.77022637
159Abnormal enzyme/coenzyme activity (HP:0012379)1.75845640
160Large eyes (HP:0001090)1.75344265
161Duplicated collecting system (HP:0000081)1.74885087
162Polycystic ovaries (HP:0000147)1.74629204
163Stomatitis (HP:0010280)1.74332828
164Abnormality of the renal collecting system (HP:0004742)1.71860500
165Subcapsular cataract (HP:0000523)1.71378932
166Hypohidrosis (HP:0000966)1.71078606
167Gaze-evoked nystagmus (HP:0000640)1.70749726
168Hypoplasia of the uterus (HP:0000013)1.70122557
169Abnormality of DNA repair (HP:0003254)1.69111858
170Testicular atrophy (HP:0000029)1.68955192
171Spinal muscular atrophy (HP:0007269)1.67756828

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.38381296
2TTK6.17010779
3MAP3K64.81539794
4STK104.32034836
5BRAF4.00707535
6TAOK33.55757243
7EEF2K3.40494852
8PLK43.39412608
9MOS2.99381752
10ERBB42.58545320
11BMPR22.57059835
12MAP3K92.46021556
13MUSK2.45450214
14NEK62.26234101
15MAP3K132.07915269
16LATS22.07535765
17CHEK22.06470535
18CAMK1D2.03611338
19KSR21.98805327
20MELK1.98445293
21MST41.97441942
22MET1.95997076
23MAPKAPK31.92062719
24LATS11.83613574
25PLK11.81482494
26MAP3K81.80807832
27CDK81.75265813
28CDC71.74759865
29MAPKAPK51.68963753
30TRIM281.55786954
31ARAF1.47375028
32PRKD31.38299945
33TAOK11.37139868
34PRKCI1.33315775
35ZAK1.32377781
36STK38L1.30681266
37MAP2K21.29655917
38CAMK1G1.27742614
39AURKA1.22225721
40LRRK21.21513296
41BUB11.20743567
42EIF2AK11.18341993
43TESK21.17446642
44BRD41.16584306
45MAP3K41.16404344
46WNK11.12730961
47NEK21.12581676
48MAPK131.08582572
49RAF11.06548537
50PTK21.05138685
51PAK61.01755897
52MAP3K71.00272479
53RET0.94948034
54AURKB0.94587278
55ZAP700.94467228
56STK30.93950829
57TGFBR10.93136499
58CDK90.92676769
59EIF2AK30.87420957
60MAP2K70.83108278
61CSNK1G10.82552510
62PIM10.80822332
63ERN10.80181103
64PLK20.77323643
65TRPM70.76681944
66MTOR0.75030326
67MAP2K10.74395460
68DYRK20.71082235
69CSNK1G30.70672082
70TNK20.68852602
71CLK10.68851182
72ICK0.66941719
73EPHA30.64972299
74TLK10.64546749
75CSF1R0.62130737
76PRKAA10.60102990
77GRK60.59714186
78RPS6KB20.59200797
79ACVR1B0.58511652
80PRKAA20.58195736
81MARK30.57989361
82CSNK1G20.56344545
83CSNK1A1L0.53027683
84INSRR0.51790595
85MAP2K40.49446675
86MAPK110.49343468
87PRKD20.48872052
88DMPK0.48501254
89PLK30.48389945
90MAP3K50.47301399
91NLK0.45268862
92ATM0.43043930
93ADRBK20.42473689
94PINK10.42050877
95NME10.41479351
96CDK50.41463050
97BRSK20.41127291
98TNIK0.41071881
99RIPK10.40884211
100EPHA40.40771422
101KSR10.40272239
102CAMK40.40237684
103ATR0.39913817
104CDC42BPA0.38385059
105CHEK10.38075714
106CDK10.38032893
107CAMK10.37758923
108LMTK20.37326834
109STK240.36345080
110ROCK20.35753856
111FLT30.35198264
112ADRBK10.33719974
113ABL20.33635888
114PRKCZ0.33517902
115CSNK1D0.32840165
116PRKG10.31277134
117CDK40.31108620
118TIE10.30423697
119NTRK20.30302887
120TYRO30.29841613
121GSK3B0.29682298
122ROCK10.29677494
123MATK0.29015485
124BRSK10.28813712
125RPS6KB10.27059348
126NTRK10.25478154
127MAPK100.25348052
128CDK20.24804881
129ABL10.24064631
130MARK20.23651518
131KIT0.23319320
132NEK90.23255525
133AKT20.21326622
134MAPK140.20929153
135PRKCQ0.20573699
136CSNK1E0.20352148
137CAMK2A0.20176602
138STK380.19494489
139PAK10.19291211
140NEK10.18951295
141MAP3K10.16780452
142STK110.13053267
143AKT10.12905939
144CSNK1A10.10992162
145CDK150.10225617
146CDK70.09888764
147MAPK10.08593021
148CDK180.07493049
149NUAK10.07429076
150MAPKAPK20.07268210
151CHUK0.06934449
152RPS6KA10.06196650

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.79170728
2Vitamin B6 metabolism_Homo sapiens_hsa007504.33405550
3Cell cycle_Homo sapiens_hsa041104.22179482
4RNA degradation_Homo sapiens_hsa030183.42438128
5Homologous recombination_Homo sapiens_hsa034403.07751846
6Basal transcription factors_Homo sapiens_hsa030223.04503705
7Fanconi anemia pathway_Homo sapiens_hsa034602.62585476
8Oocyte meiosis_Homo sapiens_hsa041142.57618111
9Circadian rhythm_Homo sapiens_hsa047102.40300198
10Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.31548960
11Non-homologous end-joining_Homo sapiens_hsa034502.25786161
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.22172004
13Caffeine metabolism_Homo sapiens_hsa002322.14646111
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11596918
15Linoleic acid metabolism_Homo sapiens_hsa005912.09187642
16Ether lipid metabolism_Homo sapiens_hsa005652.06833331
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98062607
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.91392124
19Pancreatic cancer_Homo sapiens_hsa052121.90053317
20Base excision repair_Homo sapiens_hsa034101.89981273
21Mismatch repair_Homo sapiens_hsa034301.89138523
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.79863681
23Other glycan degradation_Homo sapiens_hsa005111.76886957
24MicroRNAs in cancer_Homo sapiens_hsa052061.68677765
25DNA replication_Homo sapiens_hsa030301.62059992
26p53 signaling pathway_Homo sapiens_hsa041151.57879776
27RNA transport_Homo sapiens_hsa030131.55529067
28Dorso-ventral axis formation_Homo sapiens_hsa043201.53812492
29GnRH signaling pathway_Homo sapiens_hsa049121.49712535
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49403110
31RNA polymerase_Homo sapiens_hsa030201.43879803
32Olfactory transduction_Homo sapiens_hsa047401.27834261
33ABC transporters_Homo sapiens_hsa020101.21331931
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19147806
35Nucleotide excision repair_Homo sapiens_hsa034201.19132893
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13928860
37TGF-beta signaling pathway_Homo sapiens_hsa043501.12424514
38Arginine biosynthesis_Homo sapiens_hsa002201.08108662
39Glycerophospholipid metabolism_Homo sapiens_hsa005641.05328348
40mRNA surveillance pathway_Homo sapiens_hsa030151.00874939
41Choline metabolism in cancer_Homo sapiens_hsa052311.00724409
42Taste transduction_Homo sapiens_hsa047421.00472102
43Prolactin signaling pathway_Homo sapiens_hsa049171.00290605
44Colorectal cancer_Homo sapiens_hsa052100.97370502
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94283654
46Regulation of autophagy_Homo sapiens_hsa041400.93212097
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92021519
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91135184
49Complement and coagulation cascades_Homo sapiens_hsa046100.87179977
50VEGF signaling pathway_Homo sapiens_hsa043700.86190604
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84754978
52GABAergic synapse_Homo sapiens_hsa047270.83372600
53Morphine addiction_Homo sapiens_hsa050320.82271354
54Phototransduction_Homo sapiens_hsa047440.80826396
55Nicotine addiction_Homo sapiens_hsa050330.80621444
56Purine metabolism_Homo sapiens_hsa002300.77497555
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77398125
58Hippo signaling pathway_Homo sapiens_hsa043900.72508605
59Arginine and proline metabolism_Homo sapiens_hsa003300.69935312
60Long-term depression_Homo sapiens_hsa047300.69594744
61mTOR signaling pathway_Homo sapiens_hsa041500.68998154
62FoxO signaling pathway_Homo sapiens_hsa040680.68739064
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.64950017
64Ras signaling pathway_Homo sapiens_hsa040140.63725013
65Inositol phosphate metabolism_Homo sapiens_hsa005620.63559054
66Folate biosynthesis_Homo sapiens_hsa007900.63144786
67Renal cell carcinoma_Homo sapiens_hsa052110.62292056
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61286126
69Pyruvate metabolism_Homo sapiens_hsa006200.60435032
70Bile secretion_Homo sapiens_hsa049760.58656635
71Herpes simplex infection_Homo sapiens_hsa051680.56818766
72Fatty acid elongation_Homo sapiens_hsa000620.56742577
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55264275
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52866534
75Pyrimidine metabolism_Homo sapiens_hsa002400.52231370
76Adherens junction_Homo sapiens_hsa045200.49901485
77HTLV-I infection_Homo sapiens_hsa051660.49490309
78T cell receptor signaling pathway_Homo sapiens_hsa046600.49353570
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.48469108
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46836833
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42937193
82Estrogen signaling pathway_Homo sapiens_hsa049150.41157556
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39994638
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39140753
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39076845
86Notch signaling pathway_Homo sapiens_hsa043300.38554519
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38435353
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37436851
89Arachidonic acid metabolism_Homo sapiens_hsa005900.37273516
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37179674
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37156554
92Glutamatergic synapse_Homo sapiens_hsa047240.36657157
93Thyroid cancer_Homo sapiens_hsa052160.36544431
94HIF-1 signaling pathway_Homo sapiens_hsa040660.35645015
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.34861895
96Protein digestion and absorption_Homo sapiens_hsa049740.33665273
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33467826
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33348651
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32945266
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31994141
101Histidine metabolism_Homo sapiens_hsa003400.31256741
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31016806
103Hedgehog signaling pathway_Homo sapiens_hsa043400.30581372
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30121848
105Chronic myeloid leukemia_Homo sapiens_hsa052200.28931432
106Small cell lung cancer_Homo sapiens_hsa052220.27845168
107Endometrial cancer_Homo sapiens_hsa052130.27106911
108Gap junction_Homo sapiens_hsa045400.26646640
109Primary immunodeficiency_Homo sapiens_hsa053400.26452763
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.25818183
111N-Glycan biosynthesis_Homo sapiens_hsa005100.25550926
112Wnt signaling pathway_Homo sapiens_hsa043100.24945129
113Bladder cancer_Homo sapiens_hsa052190.24570416
114Huntingtons disease_Homo sapiens_hsa050160.23232300
115Lysine degradation_Homo sapiens_hsa003100.22860432
116MAPK signaling pathway_Homo sapiens_hsa040100.22499688
117Non-small cell lung cancer_Homo sapiens_hsa052230.21750406
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.21461607
119Serotonergic synapse_Homo sapiens_hsa047260.21265220
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.20771849
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20761926
122Shigellosis_Homo sapiens_hsa051310.19965571
123Propanoate metabolism_Homo sapiens_hsa006400.19386082
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19380028
125Insulin secretion_Homo sapiens_hsa049110.19139510
126Hepatitis B_Homo sapiens_hsa051610.18713228
127Prostate cancer_Homo sapiens_hsa052150.18428456
128TNF signaling pathway_Homo sapiens_hsa046680.18424179
129Amphetamine addiction_Homo sapiens_hsa050310.18283847
130Amoebiasis_Homo sapiens_hsa051460.17698732
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17129334
132beta-Alanine metabolism_Homo sapiens_hsa004100.16781498
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.16312465
134Cholinergic synapse_Homo sapiens_hsa047250.16297688
135Glioma_Homo sapiens_hsa052140.16251006
136Apoptosis_Homo sapiens_hsa042100.16091047
137Synaptic vesicle cycle_Homo sapiens_hsa047210.15124341
138Steroid biosynthesis_Homo sapiens_hsa001000.14969475
139Calcium signaling pathway_Homo sapiens_hsa040200.14352722
140Fatty acid biosynthesis_Homo sapiens_hsa000610.14305564
141Phagosome_Homo sapiens_hsa041450.14243197
142ErbB signaling pathway_Homo sapiens_hsa040120.14166066
143Glycosaminoglycan degradation_Homo sapiens_hsa005310.14113600
144Viral carcinogenesis_Homo sapiens_hsa052030.13916682
145Melanoma_Homo sapiens_hsa052180.13193978
146cAMP signaling pathway_Homo sapiens_hsa040240.11974449
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11960430
148Epstein-Barr virus infection_Homo sapiens_hsa051690.11388253
149Long-term potentiation_Homo sapiens_hsa047200.10712480
150Nitrogen metabolism_Homo sapiens_hsa009100.10456469
151Pathways in cancer_Homo sapiens_hsa052000.09780058

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