ZP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1citrulline biosynthetic process (GO:0019240)9.01171778
2regulation of hypersensitivity (GO:0002883)8.92425099
3DNA methylation involved in gamete generation (GO:0043046)7.65410626
4regulation of exit from mitosis (GO:0007096)7.33021714
5positive regulation of humoral immune response (GO:0002922)7.03005840
6oocyte development (GO:0048599)6.94808378
7positive regulation of inflammatory response to antigenic stimulus (GO:0002863)6.77642826
8mitotic chromosome condensation (GO:0007076)6.73951933
9regulation of phospholipid biosynthetic process (GO:0071071)6.64510514
10female gamete generation (GO:0007292)6.62663558
11* regulation of acrosome reaction (GO:0060046)6.34866319
12regulation of meiosis (GO:0040020)5.97820336
13regulation of acute inflammatory response to antigenic stimulus (GO:0002864)5.91832046
14* multicellular organism reproduction (GO:0032504)5.89366800
15positive regulation of reproductive process (GO:2000243)5.83660384
16protein kinase C signaling (GO:0070528)5.82727211
17citrulline metabolic process (GO:0000052)5.59891847
18regulation of steroid hormone secretion (GO:2000831)5.52007374
19immunoglobulin mediated immune response (GO:0016064)5.48459662
20mitotic metaphase plate congression (GO:0007080)5.32016351
21base-excision repair, AP site formation (GO:0006285)5.29591068
22DNA methylation (GO:0006306)5.23597104
23DNA alkylation (GO:0006305)5.23597104
24retinal cone cell development (GO:0046549)5.09920016
25meiotic cell cycle (GO:0051321)5.09140014
26pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.07934964
27histone H2A monoubiquitination (GO:0035518)5.04062705
28positive regulation of meiosis (GO:0045836)4.98634045
29negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.98268245
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.97640972
31protein localization to kinetochore (GO:0034501)4.92711593
32* fertilization (GO:0009566)4.89489928
33notochord development (GO:0030903)4.86059836
34histone H2A ubiquitination (GO:0033522)4.85184080
35peptidyl-arginine modification (GO:0018195)4.83080234
36* sperm-egg recognition (GO:0035036)4.78031174
37regulation of meiotic cell cycle (GO:0051445)4.70075632
38positive regulation of meiotic cell cycle (GO:0051446)4.67171221
39* regulation of calcium ion-dependent exocytosis (GO:0017158)4.66489562
40metaphase plate congression (GO:0051310)4.65881188
41mitotic sister chromatid segregation (GO:0000070)4.62837979
42* negative regulation of reproductive process (GO:2000242)4.60027871
43establishment of chromosome localization (GO:0051303)4.58203529
44negative regulation of histone methylation (GO:0031061)4.57231431
45protein K6-linked ubiquitination (GO:0085020)4.54045933
46interkinetic nuclear migration (GO:0022027)4.51261934
47* reproduction (GO:0000003)4.45165254
48gene silencing by RNA (GO:0031047)4.44172906
49male meiosis (GO:0007140)4.37598453
50protein localization to chromosome, centromeric region (GO:0071459)4.37096712
51regulation of sister chromatid cohesion (GO:0007063)4.36784028
52oocyte maturation (GO:0001556)4.32069762
53microtubule severing (GO:0051013)4.23279790
54oogenesis (GO:0048477)4.21911957
55negative regulation of meiosis (GO:0045835)4.20781672
56pyrimidine nucleotide catabolic process (GO:0006244)4.19561954
57* regulation of reproductive process (GO:2000241)4.15434057
58negative regulation of smooth muscle cell differentiation (GO:0051151)4.15074667
59attachment of spindle microtubules to kinetochore (GO:0008608)4.14725714
60histone H3-K9 demethylation (GO:0033169)4.02464233
61N-terminal protein amino acid acetylation (GO:0006474)4.00212650
62B cell mediated immunity (GO:0019724)3.98164999
63phosphatidylinositol dephosphorylation (GO:0046856)3.92328090
64glycine transport (GO:0015816)3.92113766
65* cell-cell recognition (GO:0009988)3.84731896
66synaptonemal complex assembly (GO:0007130)3.82289099
67* single fertilization (GO:0007338)3.82159279
68DNA methylation or demethylation (GO:0044728)3.82077357
69regulation of DNA methylation (GO:0044030)3.79659294
70sister chromatid segregation (GO:0000819)3.78340616
71regulation of retinoic acid receptor signaling pathway (GO:0048385)3.77407340
72positive regulation of interleukin-4 production (GO:0032753)3.70052726
73DNA modification (GO:0006304)3.68487836
74phospholipid dephosphorylation (GO:0046839)3.66250442
75positive regulation of mitotic sister chromatid separation (GO:1901970)3.62460536
76positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.62460536
77positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.62460536
78regulation of histone H3-K9 methylation (GO:0051570)3.61873667
79negative regulation of DNA-templated transcription, elongation (GO:0032785)3.58889832
80negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.58889832
81positive regulation of chromosome segregation (GO:0051984)3.58555101
82positive regulation of histone H3-K4 methylation (GO:0051571)3.58495128
83positive regulation of calcium ion import (GO:0090280)3.58173277
84regulation of steroid hormone biosynthetic process (GO:0090030)3.55780032
85protein localization to chromosome (GO:0034502)3.54701488
86female gonad development (GO:0008585)3.54502233
87regulation of chromatin silencing (GO:0031935)3.50664008
88regulation of histone H3-K4 methylation (GO:0051569)3.50533422
89positive regulation of histone methylation (GO:0031062)3.48199865
90endothelium development (GO:0003158)3.47930047
91glycerophospholipid catabolic process (GO:0046475)3.47336910
92negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.44487402
93regulation of cell maturation (GO:1903429)3.43496801
94synaptonemal complex organization (GO:0070193)3.42130715
95spindle checkpoint (GO:0031577)3.41891227
96neurotransmitter catabolic process (GO:0042135)3.40617791
97regulation of spindle organization (GO:0090224)3.39206794
98histone H3-K4 trimethylation (GO:0080182)3.37620551
99regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.36462926
100stress granule assembly (GO:0034063)3.35732934
101ovulation cycle (GO:0042698)3.34046022
102histone lysine demethylation (GO:0070076)3.33831561
103regulation of meiosis I (GO:0060631)3.32677920
104negative regulation of meiotic cell cycle (GO:0051447)3.32108229
105chaperone-mediated protein transport (GO:0072321)3.28968020
106positive regulation of gastrulation (GO:2000543)3.28565432
107embryo implantation (GO:0007566)3.27035687
108chromosome segregation (GO:0007059)3.26012707
109DNA damage induced protein phosphorylation (GO:0006975)3.25461674
110regulation of chromatin binding (GO:0035561)3.22279882
111establishment of spindle localization (GO:0051293)3.22016006
112meiotic chromosome segregation (GO:0045132)3.19545115
113regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.18522357
114positive regulation of uterine smooth muscle contraction (GO:0070474)3.17277195
115positive regulation of exocytosis (GO:0045921)3.17269840
116regulation of mitotic spindle organization (GO:0060236)3.16670561
117histone demethylation (GO:0016577)3.16412214
118regulation of chromosome segregation (GO:0051983)3.15145180
119negative regulation of histone modification (GO:0031057)3.14601353
120aggressive behavior (GO:0002118)3.14135760
121gene silencing (GO:0016458)3.12814584
122male meiosis I (GO:0007141)3.11123680
123histone H3-K4 methylation (GO:0051568)3.11087769
124regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.10645502
125primitive streak formation (GO:0090009)3.08685277
126type B pancreatic cell development (GO:0003323)3.08653769
127* binding of sperm to zona pellucida (GO:0007339)3.07150641
128negative regulation of chromosome segregation (GO:0051985)3.06873755
129forebrain neuron development (GO:0021884)3.06183199
130regulation of mitotic metaphase/anaphase transition (GO:0030071)3.03641667
131phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.03296886
132regulation of histone methylation (GO:0031060)3.02764902
133phosphorelay signal transduction system (GO:0000160)3.01321781
134regulation of interleukin-4 production (GO:0032673)2.99469844
135regulation of cell cycle G2/M phase transition (GO:1902749)2.93260956
136positive regulation of hormone biosynthetic process (GO:0046886)2.92839828
137positive regulation of endothelial cell differentiation (GO:0045603)2.89050400
138protein dealkylation (GO:0008214)2.87822131
139protein demethylation (GO:0006482)2.87822131
140negative regulation of chromatin modification (GO:1903309)2.80980738
141regulation of corticosteroid hormone secretion (GO:2000846)2.80490459
142meiosis I (GO:0007127)2.79608478
143positive regulation of DNA-dependent DNA replication (GO:2000105)2.78628122
144DNA replication checkpoint (GO:0000076)2.74908733
145negative regulation of hormone biosynthetic process (GO:0032353)2.72286218
146positive regulation of gene expression, epigenetic (GO:0045815)2.71178110
147regulation of female gonad development (GO:2000194)15.0654179
148piRNA metabolic process (GO:0034587)10.5650648

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.19048072
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.37617553
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.29817003
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.17247398
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.91914459
6AR_21909140_ChIP-Seq_LNCAP_Human3.89250778
7E2F7_22180533_ChIP-Seq_HELA_Human3.36847018
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.87609551
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.81449332
10KAP1_22055183_ChIP-Seq_ESCs_Mouse2.80543486
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.22712876
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.14754778
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.13609773
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98128583
15E2F4_17652178_ChIP-ChIP_JURKAT_Human1.92183686
16MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.90930678
17TP63_19390658_ChIP-ChIP_HaCaT_Human1.89525639
18MYC_18940864_ChIP-ChIP_HL60_Human1.88788681
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.78306489
20IGF1R_20145208_ChIP-Seq_DFB_Human1.77273103
21GBX2_23144817_ChIP-Seq_PC3_Human1.75005500
22GATA1_26923725_Chip-Seq_HPCs_Mouse1.69645462
23TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.69278681
24HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.65102911
25RNF2_27304074_Chip-Seq_NSC_Mouse1.63700701
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63639444
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59592017
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.57739881
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.52744331
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.52744331
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.52744331
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46503260
33GATA3_21867929_ChIP-Seq_TH1_Mouse1.45530407
34* CDX2_22108803_ChIP-Seq_LS180_Human1.41458378
35NFYA_21822215_ChIP-Seq_K562_Human1.41176316
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39789398
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.35940958
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35882477
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34260589
40ESET_19884257_ChIP-Seq_ESCs_Mouse1.29242877
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28661839
42CBX2_22325352_ChIP-Seq_293T-Rex_Human1.26881107
43RUNX1_26923725_Chip-Seq_HPCs_Mouse1.26868953
44FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23493003
45ETV1_20927104_ChIP-Seq_GIST48_Human1.21895279
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20600072
47TBL1_22424771_ChIP-Seq_293T_Human1.19928035
48EWS_26573619_Chip-Seq_HEK293_Human1.19776443
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19629723
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.17103120
51GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.16907766
52STAT3_23295773_ChIP-Seq_U87_Human1.16824308
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16530619
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16530619
55* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16515022
56HNFA_21074721_ChIP-Seq_CACO-2_Human1.14892599
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14614305
58NANOG_21062744_ChIP-ChIP_HESCs_Human1.13874972
59TCF4_23295773_ChIP-Seq_U87_Human1.13869214
60* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12253659
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11799862
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10955918
63SMAD4_21741376_ChIP-Seq_EPCs_Human1.10686853
64STAT1_17558387_ChIP-Seq_HELA_Human1.10607103
65RBPJ_21746931_ChIP-Seq_IB4_Human1.09137135
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08553572
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06797269
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04747841
69SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03941986
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.02476146
71SMAD4_21799915_ChIP-Seq_A2780_Human1.01669216
72MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.00849132
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00847137
74SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99934316
75TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99926587
76AR_25329375_ChIP-Seq_VCAP_Human0.99547576
77PHF8_20622853_ChIP-Seq_HELA_Human0.99243433
78GF1B_26923725_Chip-Seq_HPCs_Mouse0.98999057
79NFYB_21822215_ChIP-Seq_K562_Human0.98966154
80NFE2_27457419_Chip-Seq_LIVER_Mouse0.98623893
81CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.98552560
82LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97719000
83TP63_23658742_ChIP-Seq_EP156T_Human0.97328093
84KDM2B_26808549_Chip-Seq_REH_Human0.97307195
85SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96277288
86NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96271252
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95860181
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95420579
89OCT4_19829295_ChIP-Seq_ESCs_Human0.95392358
90RUNX2_22187159_ChIP-Seq_PCA_Human0.94838376
91SMAD3_21741376_ChIP-Seq_EPCs_Human0.94564098
92GATA6_21074721_ChIP-Seq_CACO-2_Human0.94465763
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94428532
94* GATA3_26560356_Chip-Seq_TH1_Human0.93884625
95TCF4_18268006_ChIP-ChIP_LS174T_Human0.93515440
96GF1_26923725_Chip-Seq_HPCs_Mouse0.92021942
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.91698416
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91160099
99ZNF274_21170338_ChIP-Seq_K562_Hela0.89806471
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89673453
101* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89550078
102CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89513209
103MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.89203926
104CTCF_18555785_Chip-Seq_ESCs_Mouse0.88513899
105* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88276702
106STAT1_20625510_ChIP-Seq_HELA_Human0.88234308
107ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87845076
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87318186
109AR_21572438_ChIP-Seq_LNCaP_Human0.86846414
110* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86771375
111MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85368238
112* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85350808
113PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.84974732
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84907353
115PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84677161
116GATA3_27048872_Chip-Seq_THYMUS_Human0.84498344
117* NANOG_20526341_ChIP-Seq_ESCs_Human0.84382943
118ERG_20517297_ChIP-Seq_VCAP_Human0.83982560
119STAT3_18555785_Chip-Seq_ESCs_Mouse0.83728975
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82696870
121CBP_20019798_ChIP-Seq_JUKART_Human0.82696870
122ESRRB_18555785_Chip-Seq_ESCs_Mouse0.82617784
123ZFX_18555785_Chip-Seq_ESCs_Mouse0.82547412
124KLF4_19829295_ChIP-Seq_ESCs_Human0.81906415
125* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.81623221
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.81336405
127NANOG_18555785_Chip-Seq_ESCs_Mouse0.80892515
128ESR1_20079471_ChIP-ChIP_T-47D_Human0.80577775
129* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.80324686
130OCT4_18555785_Chip-Seq_ESCs_Mouse0.80123987
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.80112064
132* FOXH1_21741376_ChIP-Seq_EPCs_Human0.80006507
133E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79767941
134REST_21632747_ChIP-Seq_MESCs_Mouse0.79766568
135FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.79531200
136TBX5_21415370_ChIP-Seq_HL-1_Mouse0.79257669
137EZH2_27304074_Chip-Seq_ESCs_Mouse0.78079099
138PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.75764853
139SMAD3_21741376_ChIP-Seq_ESCs_Human0.75006368
140RXR_22108803_ChIP-Seq_LS180_Human0.74370300
141SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.74226584
142BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.73119403
143CBP_21632823_ChIP-Seq_H3396_Human0.73006146
144CTBP1_25329375_ChIP-Seq_LNCAP_Human0.70888024
145SMRT_27268052_Chip-Seq_Bcells_Human0.70151055
146TP53_22573176_ChIP-Seq_HFKS_Human0.69021317
147DROSHA_22980978_ChIP-Seq_HELA_Human0.68702517
148TCF4_22108803_ChIP-Seq_LS180_Human0.68164507
149CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.65571577
150ZNF217_24962896_ChIP-Seq_MCF-7_Human0.63932500
151P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.63376442
152STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.63294179
153KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.63226824
154AR_19668381_ChIP-Seq_PC3_Human0.62790513
155* SOX2_21211035_ChIP-Seq_LN229_Gbm0.62520913
156EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.62234424
157BCAT_22108803_ChIP-Seq_LS180_Human0.61911161
158P300_19829295_ChIP-Seq_ESCs_Human0.61861062
159GATA3_21878914_ChIP-Seq_MCF-7_Human0.61480487
160TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.60854563
161BMI1_23680149_ChIP-Seq_NPCS_Mouse0.60851165
162NR3C1_23031785_ChIP-Seq_PC12_Mouse0.59944204
163NCOR_22424771_ChIP-Seq_293T_Human0.58640141
164ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.58127028
165FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.57365508
166CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.56925284
167E2F1_17053090_ChIP-ChIP_MCF-7_Human0.56512531
168SMAD4_21741376_ChIP-Seq_HESCs_Human0.53414640
169JUN_21703547_ChIP-Seq_K562_Human0.53133164

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect9.94074730
2MP0003646_muscle_fatigue5.05035691
3MP0008877_abnormal_DNA_methylation4.60185523
4MP0005395_other_phenotype4.21790692
5* MP0003699_abnormal_female_reproductive3.67817306
6MP0003693_abnormal_embryo_hatching3.39292519
7MP0003121_genomic_imprinting3.35903292
8MP0010094_abnormal_chromosome_stability3.05753710
9* MP0001119_abnormal_female_reproductive2.99938497
10MP0008789_abnormal_olfactory_epithelium2.95113180
11MP0005394_taste/olfaction_phenotype2.84161150
12MP0005499_abnormal_olfactory_system2.84161150
13MP0003787_abnormal_imprinting2.76999916
14* MP0001929_abnormal_gametogenesis2.73185083
15MP0003077_abnormal_cell_cycle2.60933644
16MP0004957_abnormal_blastocyst_morpholog2.53059634
17MP0003890_abnormal_embryonic-extraembry2.49826352
18MP0005451_abnormal_body_composition2.47257806
19MP0002138_abnormal_hepatobiliary_system2.42446483
20MP0002210_abnormal_sex_determination2.26837292
21* MP0000653_abnormal_sex_gland2.26246143
22MP0003111_abnormal_nucleus_morphology2.20970184
23MP0000579_abnormal_nail_morphology2.14562893
24MP0001919_abnormal_reproductive_system1.99194609
25MP0003315_abnormal_perineum_morphology1.96129933
26* MP0002161_abnormal_fertility/fecundity1.87147721
27MP0002295_abnormal_pulmonary_circulatio1.81010379
28MP0005410_abnormal_fertilization1.80066598
29MP0010307_abnormal_tumor_latency1.67966047
30MP0005646_abnormal_pituitary_gland1.67340739
31MP0010030_abnormal_orbit_morphology1.67213492
32MP0008875_abnormal_xenobiotic_pharmacok1.63498749
33MP0006292_abnormal_olfactory_placode1.59875928
34MP0008932_abnormal_embryonic_tissue1.56350969
35MP0003183_abnormal_peptide_metabolism1.54337652
36MP0002234_abnormal_pharynx_morphology1.53665638
37MP0001905_abnormal_dopamine_level1.52889802
38MP0005389_reproductive_system_phenotype1.52425760
39MP0000566_synostosis1.50241150
40MP0010234_abnormal_vibrissa_follicle1.50073757
41MP0004264_abnormal_extraembryonic_tissu1.48133383
42MP0006072_abnormal_retinal_apoptosis1.40873744
43MP0005187_abnormal_penis_morphology1.40350595
44MP0001730_embryonic_growth_arrest1.39247760
45MP0002102_abnormal_ear_morphology1.37615309
46MP0003950_abnormal_plasma_membrane1.35731773
47MP0000631_abnormal_neuroendocrine_gland1.34617015
48MP0001145_abnormal_male_reproductive1.34559832
49MP0002653_abnormal_ependyma_morphology1.34316899
50MP0003123_paternal_imprinting1.32418987
51MP0009384_cardiac_valve_regurgitation1.27308564
52MP0004859_abnormal_synaptic_plasticity1.27274887
53MP0003937_abnormal_limbs/digits/tail_de1.26763902
54MP0005380_embryogenesis_phenotype1.23557446
55MP0001672_abnormal_embryogenesis/_devel1.23557446
56MP0003252_abnormal_bile_duct1.20952502
57MP0002160_abnormal_reproductive_system1.17671883
58MP0000350_abnormal_cell_proliferation1.17347129
59MP0002877_abnormal_melanocyte_morpholog1.16909343
60MP0001664_abnormal_digestion1.16158722
61MP0002249_abnormal_larynx_morphology1.13089443
62MP0002272_abnormal_nervous_system1.12245511
63MP0005360_urolithiasis1.11699438
64MP0002932_abnormal_joint_morphology1.09614612
65MP0001346_abnormal_lacrimal_gland1.07900896
66MP0001986_abnormal_taste_sensitivity1.07386080
67MP0009697_abnormal_copulation1.06839782
68MP0001666_abnormal_nutrient_absorption1.04544948
69MP0002085_abnormal_embryonic_tissue1.04353080
70MP0008057_abnormal_DNA_replication1.01777972
71MP0005310_abnormal_salivary_gland1.00829095
72MP0003119_abnormal_digestive_system0.97348029
73MP0006276_abnormal_autonomic_nervous0.96087780
74MP0003959_abnormal_lean_body0.93396815
75MP0001984_abnormal_olfaction0.90825648
76MP0001293_anophthalmia0.90567962
77MP0002233_abnormal_nose_morphology0.89778284
78MP0003329_amyloid_beta_deposits0.89522118
79MP0001529_abnormal_vocalization0.87332914
80MP0003763_abnormal_thymus_physiology0.86521303
81MP0002019_abnormal_tumor_incidence0.86285737
82MP0005551_abnormal_eye_electrophysiolog0.84329045
83MP0000465_gastrointestinal_hemorrhage0.83897107
84MP0003868_abnormal_feces_composition0.82847148
85MP0005085_abnormal_gallbladder_physiolo0.81665533
86MP0005647_abnormal_sex_gland0.81467896
87MP0003136_yellow_coat_color0.80684486
88MP0000613_abnormal_salivary_gland0.80353180
89MP0003453_abnormal_keratinocyte_physiol0.80141260
90MP0001485_abnormal_pinna_reflex0.79729694
91MP0001697_abnormal_embryo_size0.79098955
92MP0004142_abnormal_muscle_tone0.76599677
93MP0005257_abnormal_intraocular_pressure0.76596876
94MP0004185_abnormal_adipocyte_glucose0.74901173
95MP0000762_abnormal_tongue_morphology0.74664916
96MP0005409_darkened_coat_color0.74280579
97MP0002084_abnormal_developmental_patter0.73564854
98MP0005408_hypopigmentation0.73544576
99MP0003879_abnormal_hair_cell0.73107086
100MP0001915_intracranial_hemorrhage0.72171216
101MP0001502_abnormal_circadian_rhythm0.70928631
102MP0002282_abnormal_trachea_morphology0.70058335
103MP0003698_abnormal_male_reproductive0.69798306
104MP0002254_reproductive_system_inflammat0.69507532
105MP0002089_abnormal_postnatal_growth/wei0.67698853
106MP0010368_abnormal_lymphatic_system0.66043330
107MP0008260_abnormal_autophagy0.64814408
108MP0000733_abnormal_muscle_development0.64431387
109MP0010386_abnormal_urinary_bladder0.64068724
110MP0000462_abnormal_digestive_system0.63786943
111MP0000639_abnormal_adrenal_gland0.63185119
112MP0001324_abnormal_eye_pigmentation0.61512667
113MP0003656_abnormal_erythrocyte_physiolo0.61353635
114MP0003705_abnormal_hypodermis_morpholog0.60552937
115MP0000383_abnormal_hair_follicle0.60205516
116MP0002734_abnormal_mechanical_nocicepti0.59847950
117MP0008007_abnormal_cellular_replicative0.59345291
118MP0005621_abnormal_cell_physiology0.59279209
119MP0005197_abnormal_uvea_morphology0.59240084
120MP0010678_abnormal_skin_adnexa0.58832421
121MP0002127_abnormal_cardiovascular_syste0.58419667
122MP0001963_abnormal_hearing_physiology0.58378502
123MP0004270_analgesia0.58113201
124MP0003755_abnormal_palate_morphology0.56744385
125MP0003880_abnormal_central_pattern0.56088190
126MP0003806_abnormal_nucleotide_metabolis0.55455045
127MP0003635_abnormal_synaptic_transmissio0.55222859
128MP0002735_abnormal_chemical_nociception0.54768796
129MP0009745_abnormal_behavioral_response0.53742214
130MP0004036_abnormal_muscle_relaxation0.53681740
131MP0005384_cellular_phenotype0.53405554
132MP0002229_neurodegeneration0.51380212
133MP0005023_abnormal_wound_healing0.51379926
134MP0002269_muscular_atrophy0.49486056
135MP0002928_abnormal_bile_duct0.49194545
136MP0004782_abnormal_surfactant_physiolog0.48981167
137MP0000313_abnormal_cell_death0.48170594
138MP0008058_abnormal_DNA_repair0.48029996
139MP0001545_abnormal_hematopoietic_system0.47869353
140MP0005397_hematopoietic_system_phenotyp0.47869353
141MP0000427_abnormal_hair_cycle0.47284074
142MP0005645_abnormal_hypothalamus_physiol0.46953424
143MP0000678_abnormal_parathyroid_gland0.46233442
144MP0009840_abnormal_foam_cell0.45048624
145MP0000015_abnormal_ear_pigmentation0.44544194
146MP0003861_abnormal_nervous_system0.44447162
147MP0003984_embryonic_growth_retardation0.44317334
148MP0003195_calcinosis0.44055200
149MP0002139_abnormal_hepatobiliary_system0.43935272
150MP0005076_abnormal_cell_differentiation0.43439892
151MP0000049_abnormal_middle_ear0.43409358
152MP0002177_abnormal_outer_ear0.43249934
153MP0003935_abnormal_craniofacial_develop0.42556063
154MP0000604_amyloidosis0.41641789

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)7.38357076
2Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)7.18129664
3Premature ovarian failure (HP:0008209)6.97645182
4Abnormal gallbladder physiology (HP:0012438)5.73245703
5Cholecystitis (HP:0001082)5.73245703
6Impulsivity (HP:0100710)5.68665050
7Infertility (HP:0000789)5.27572747
8Male infertility (HP:0003251)4.95410196
9Deep venous thrombosis (HP:0002625)4.73209560
10Aplasia/Hypoplasia of the macula (HP:0008059)4.71760644
11Chromsome breakage (HP:0040012)4.65563920
12Malnutrition (HP:0004395)4.65191526
13Atelectasis (HP:0100750)4.63528452
14Abdominal situs inversus (HP:0003363)4.51563062
15Abnormality of abdominal situs (HP:0011620)4.51563062
16Aplasia/Hypoplasia affecting the retina (HP:0008061)4.34962718
17Apathy (HP:0000741)4.19766443
18Osteomalacia (HP:0002749)4.18983846
19Papillary thyroid carcinoma (HP:0002895)4.06996863
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.99901816
21Secondary amenorrhea (HP:0000869)3.91052583
22Rhabdomyosarcoma (HP:0002859)3.89369739
23Hypophosphatemic rickets (HP:0004912)3.86574336
24Diminished motivation (HP:0000745)3.84012558
25Birth length less than 3rd percentile (HP:0003561)3.82412241
26Insulin-resistant diabetes mellitus (HP:0000831)3.82135004
27Flat capital femoral epiphysis (HP:0003370)3.74122742
28Hypergonadotropic hypogonadism (HP:0000815)3.58345597
29Villous atrophy (HP:0011473)3.55389635
30Abnormality of small intestinal villus morphology (HP:0011472)3.55389635
31Abnormality of the labia minora (HP:0012880)3.52635833
32Facial hemangioma (HP:0000329)3.32982817
33Abnormality of chromosome segregation (HP:0002916)3.24234532
34Breast hypoplasia (HP:0003187)3.18560941
35Pulmonary fibrosis (HP:0002206)3.08318258
36Septo-optic dysplasia (HP:0100842)3.07216152
37Patellar aplasia (HP:0006443)3.06588312
38Abnormality of the anterior chamber (HP:0000593)3.00723301
39Azoospermia (HP:0000027)2.99646985
40Hyperglycemia (HP:0003074)2.97746497
41Acute myeloid leukemia (HP:0004808)2.82891316
42Shawl scrotum (HP:0000049)2.79744358
43Abnormality of the proximal phalanges of the hand (HP:0009834)2.79386809
44Hypokinesia (HP:0002375)2.76541997
45Aplasia/Hypoplasia of the patella (HP:0006498)2.76434525
46Abnormality of the fovea (HP:0000493)2.75628150
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.74805316
48Neoplasm of striated muscle (HP:0009728)2.72241317
49Aplasia of the musculature (HP:0100854)2.71084226
50Truncal obesity (HP:0001956)2.64058049
51Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.61815744
52Gonadotropin excess (HP:0000837)2.61465312
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.52061882
54Hypoplasia of the fovea (HP:0007750)2.52061882
55Aplasia/Hypoplasia of the earlobes (HP:0009906)2.51977277
56Primary amenorrhea (HP:0000786)2.41851547
57Supranuclear gaze palsy (HP:0000605)2.41423597
58Oligodactyly (hands) (HP:0001180)2.41120489
59Congenital sensorineural hearing impairment (HP:0008527)2.38237071
60Cone-rod dystrophy (HP:0000548)2.36805567
61Sandal gap (HP:0001852)2.36223622
62Loss of speech (HP:0002371)2.34122699
63Aplasia/Hypoplasia of the sternum (HP:0006714)2.32925188
64Abnormality of placental membranes (HP:0011409)2.32672455
65Amniotic constriction ring (HP:0009775)2.32672455
66Absent septum pellucidum (HP:0001331)2.31451424
67Chronic bronchitis (HP:0004469)2.30365601
68Arterial tortuosity (HP:0005116)2.30310646
69Anhidrosis (HP:0000970)2.29881242
70Anterior segment dysgenesis (HP:0007700)2.29660865
71Adrenal hypoplasia (HP:0000835)2.28663734
72Aplasia/Hypoplasia of the breasts (HP:0010311)2.28353271
73Carpal bone hypoplasia (HP:0001498)2.28170670
74Combined immunodeficiency (HP:0005387)2.26612142
75Median cleft lip (HP:0000161)2.23948642
76Capillary hemangiomas (HP:0005306)2.23511445
77Metaphyseal irregularity (HP:0003025)2.21393852
78Increased circulating renin level (HP:0000848)2.20534377
79Hypoparathyroidism (HP:0000829)2.19419551
80Breast aplasia (HP:0100783)2.19095742
81Anosmia (HP:0000458)2.17985259
82Bundle branch block (HP:0011710)2.16045868
83Abnormal spermatogenesis (HP:0008669)2.15091258
84Lower limb hyperreflexia (HP:0002395)2.14916039
85Neurofibrillary tangles (HP:0002185)2.14520829
86Urethral obstruction (HP:0000796)2.13553428
87Supernumerary spleens (HP:0009799)2.11882846
88Small intestinal stenosis (HP:0012848)2.11581936
89Duodenal stenosis (HP:0100867)2.11581936
90Dysdiadochokinesis (HP:0002075)2.10969072
91Sloping forehead (HP:0000340)2.09743355
92Skin pits (HP:0100276)2.09277849
93Posterior embryotoxon (HP:0000627)2.09191432
94Lip pit (HP:0100267)2.08990704
95Fetal akinesia sequence (HP:0001989)2.07818778
96Wrist flexion contracture (HP:0001239)2.07644801
97Spinal cord compression (HP:0002176)2.07452238
98Fair hair (HP:0002286)2.07381474
99Gaze-evoked nystagmus (HP:0000640)2.06733145
100Hyperthyroidism (HP:0000836)2.02114292
101Abnormality of the line of Schwalbe (HP:0008048)2.02027799
102Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.00809019
103Obstructive sleep apnea (HP:0002870)2.00720875
104Hypogonadotrophic hypogonadism (HP:0000044)2.00293677
105Aplasia involving bones of the upper limbs (HP:0009823)2.00027085
106Aplasia of the phalanges of the hand (HP:0009802)2.00027085
107Aplasia involving bones of the extremities (HP:0009825)2.00027085
108Abnormality of the septum pellucidum (HP:0007375)1.99530340
109Abnormality of the epiphysis of the femoral head (HP:0010574)1.99184186
110Nephroblastoma (Wilms tumor) (HP:0002667)1.97736248
111Short tibia (HP:0005736)1.95821320
112Vascular tortuosity (HP:0004948)1.95672191
113Subcapsular cataract (HP:0000523)1.95129603
114Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.94656525
115Shallow orbits (HP:0000586)1.94157697
116Abnormal lung lobation (HP:0002101)1.92424455
117Abnormality of chromosome stability (HP:0003220)1.91513417
118Fibular aplasia (HP:0002990)1.91376186
119Intrahepatic cholestasis (HP:0001406)1.90867384
120Cholelithiasis (HP:0001081)1.89647488
121Aplasia/Hypoplasia involving the musculature (HP:0001460)1.89097584
122Abnormality of cochlea (HP:0000375)1.86635126
123Thyroid carcinoma (HP:0002890)1.86542512
124Aplasia/Hypoplasia of the uvula (HP:0010293)1.84674388
125Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.84058885
126Short 1st metacarpal (HP:0010034)1.84058885
127Tubulointerstitial nephritis (HP:0001970)1.83732639
128Bronchiectasis (HP:0002110)1.83610489
129Embryonal renal neoplasm (HP:0011794)1.83097013
130Abnormality of the femoral head (HP:0003368)1.83000891
131Aplasia/Hypoplasia of the tongue (HP:0010295)1.82832816
132Oligodactyly (HP:0012165)1.81799411
133Dysmetric saccades (HP:0000641)1.81756590
134Decreased circulating renin level (HP:0003351)1.81605264
135Aplasia/Hypoplasia of the tibia (HP:0005772)1.80954559
136Abnormality of midbrain morphology (HP:0002418)1.80848495
137Molar tooth sign on MRI (HP:0002419)1.80848495
138Chronic hepatic failure (HP:0100626)1.78912568
139Medulloblastoma (HP:0002885)1.78838372
140Abnormality of femoral epiphyses (HP:0006499)1.78423890
141Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.78423890
142Striae distensae (HP:0001065)1.78197157
143Absent radius (HP:0003974)1.75549566
144Abnormal gallbladder morphology (HP:0012437)1.75246133
145Myokymia (HP:0002411)1.74355772
146Sensory axonal neuropathy (HP:0003390)1.72520605
147Aplasia involving forearm bones (HP:0009822)1.71453052
148Absent forearm bone (HP:0003953)1.71453052
149Nonprogressive disorder (HP:0003680)1.70445217
150Meckel diverticulum (HP:0002245)1.69734234
151Enlarged penis (HP:0000040)1.67590797
152Abnormal ciliary motility (HP:0012262)1.67423443
153Hypercortisolism (HP:0001578)1.67366055
154Progressive sensorineural hearing impairment (HP:0000408)1.66774921
155Non-midline cleft lip (HP:0100335)1.66608995
156Hyperactive renin-angiotensin system (HP:0000841)1.65246061
157Abnormality of the ileum (HP:0001549)1.64701476
158Abnormality of monocarboxylic acid metabolism (HP:0010996)1.63512602
159Conjunctival telangiectasia (HP:0000524)1.60877850
160Maternal diabetes (HP:0009800)1.60617131
161Abnormality of the preputium (HP:0100587)1.60227381
162Limb hypertonia (HP:0002509)1.59653138
163Esotropia (HP:0000565)1.56992962

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K65.42074216
2TAOK35.19473788
3TTK4.04540607
4STK103.43155208
5BRAF3.05813803
6MOS2.81534279
7NEK62.81163773
8EEF2K2.80001143
9PLK42.75008535
10LATS22.67416651
11PRKD32.59012705
12MAP3K92.52014714
13ERBB42.50620133
14CAMK1D2.47767878
15KSR22.44964816
16CHEK22.44373871
17LATS12.41137121
18TRIM282.37235117
19BMPR22.35307456
20MUSK2.27629168
21MET2.20555831
22MAP3K132.01512541
23MELK1.85294822
24TNIK1.79234841
25CDC71.77572266
26TAOK11.75797767
27BRSK11.74398690
28CAMK1G1.69048204
29BRD41.66481964
30CDK81.62810047
31MAP3K81.53473049
32PLK11.51327005
33MAPKAPK51.50116044
34ARAF1.49393738
35WNK11.45449841
36MAPKAPK31.41531049
37PRKCI1.40248426
38STK38L1.40109445
39AURKA1.30253755
40MAPK131.25461869
41NEK21.21379631
42MAP3K41.20724478
43TGFBR11.18193261
44STK31.18138898
45PTK21.13968742
46CSNK1G11.09797946
47PINK11.07722143
48RAF11.01709845
49MAP2K71.01564917
50AURKB0.96539286
51PRKD20.95663690
52CDK90.94615258
53LRRK20.92250629
54NTRK30.89925730
55RET0.89577086
56ZAK0.84258834
57PRKAA10.82940929
58EIF2AK30.81649466
59DYRK20.79537778
60MST40.79537565
61NTRK20.79273241
62BUB10.78552603
63STK390.74903975
64TYRO30.74681755
65MARK30.74481570
66PAK60.72565645
67BMPR1B0.71195465
68CSNK1G30.69247862
69EIF2AK10.68540720
70CSNK1G20.66156075
71TESK20.65792000
72CAMK40.65309551
73PRKAA20.65134293
74BRSK20.65016785
75NEK10.64897871
76MAP2K40.64709408
77TNK20.64061435
78DMPK0.62961496
79PIM10.62310958
80TIE10.61326398
81NME10.60979506
82PRKCZ0.60506822
83PDK30.59190097
84PDK40.59190097
85PKN10.57923151
86ACVR1B0.57760251
87TRPM70.57404357
88NLK0.56940014
89STK240.56109665
90CHEK10.55396979
91PLK20.54303475
92CDK50.53466782
93ATM0.52489916
94PAK10.52440635
95KSR10.52273790
96CSNK1A1L0.50835438
97MAPK100.48277904
98CSNK1D0.47570156
99CAMK10.46741097
100RPS6KB20.46096348
101CDK40.45562233
102CDC42BPA0.44392874
103GSK3B0.43617043
104NUAK10.43400368
105MAP3K70.43368986
106CDK30.41788022
107CDK10.41076737
108TLK10.40796082
109ABL20.40787184
110ERN10.40511216
111MAP3K20.40266329
112PRKG10.39698437
113MAP3K50.38446368
114ABL10.36288751
115ZAP700.35435162
116MAP3K10.33463223
117CDK70.33446640
118PLK30.33203235
119EPHA40.33188283
120OXSR10.32732394
121MAPK110.31989335
122CSNK1E0.31418006
123PDK10.30095715
124FLT30.29672034
125ATR0.29379207
126CDK20.28531842
127CDK120.28411176
128PRKACA0.28205220
129EPHA30.27589724
130AKT10.26204841
131MTOR0.25837504
132MAPK140.25122286
133CLK10.25117493
134RPS6KA40.23021994
135ROCK20.21850685
136STK380.21611794
137ADRBK10.20766163
138SGK4940.19297132
139SGK2230.19297132
140CSNK1A10.18195756
141ROCK10.16132114
142STK110.15401077
143CDK190.13987291
144MARK20.13825861
145CAMK2A0.13725624
146MAPK10.13591709
147SGK20.13412550

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049135.27182789
2Cell cycle_Homo sapiens_hsa041103.65990876
3Basal transcription factors_Homo sapiens_hsa030223.10913110
4Vitamin B6 metabolism_Homo sapiens_hsa007503.05616919
5RNA degradation_Homo sapiens_hsa030182.88783651
6Dorso-ventral axis formation_Homo sapiens_hsa043202.75080671
7Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.60523350
8Oocyte meiosis_Homo sapiens_hsa041142.48888951
9Cysteine and methionine metabolism_Homo sapiens_hsa002702.44683000
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.42001280
11Linoleic acid metabolism_Homo sapiens_hsa005912.34335346
12Circadian rhythm_Homo sapiens_hsa047102.19393173
13Ether lipid metabolism_Homo sapiens_hsa005652.10126328
14Homologous recombination_Homo sapiens_hsa034402.08890613
15Non-homologous end-joining_Homo sapiens_hsa034502.03956600
16Fanconi anemia pathway_Homo sapiens_hsa034602.01845347
17Pancreatic cancer_Homo sapiens_hsa052121.95792242
18MicroRNAs in cancer_Homo sapiens_hsa052061.89808356
19p53 signaling pathway_Homo sapiens_hsa041151.85854190
20RNA transport_Homo sapiens_hsa030131.81506493
21GnRH signaling pathway_Homo sapiens_hsa049121.72822039
22Caffeine metabolism_Homo sapiens_hsa002321.71990535
23mTOR signaling pathway_Homo sapiens_hsa041501.65527408
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.60654019
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54722680
26Olfactory transduction_Homo sapiens_hsa047401.52338022
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37430133
28ABC transporters_Homo sapiens_hsa020101.37297411
29GABAergic synapse_Homo sapiens_hsa047271.34979685
30Base excision repair_Homo sapiens_hsa034101.33613196
31Nicotine addiction_Homo sapiens_hsa050331.31800097
32Phototransduction_Homo sapiens_hsa047441.25291820
33Steroid biosynthesis_Homo sapiens_hsa001001.20055619
34Choline metabolism in cancer_Homo sapiens_hsa052311.18944636
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17266930
36Colorectal cancer_Homo sapiens_hsa052101.16494725
37TGF-beta signaling pathway_Homo sapiens_hsa043501.15777323
38Taste transduction_Homo sapiens_hsa047421.15734996
39RNA polymerase_Homo sapiens_hsa030201.15575464
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.09799715
41Morphine addiction_Homo sapiens_hsa050321.07842028
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.07348753
43VEGF signaling pathway_Homo sapiens_hsa043701.06778443
44Prolactin signaling pathway_Homo sapiens_hsa049171.05228725
45Bile secretion_Homo sapiens_hsa049761.04056212
46Folate biosynthesis_Homo sapiens_hsa007900.97673989
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97270177
48Renal cell carcinoma_Homo sapiens_hsa052110.95623244
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95417960
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95332629
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93277510
52Inositol phosphate metabolism_Homo sapiens_hsa005620.90709354
53Long-term depression_Homo sapiens_hsa047300.90410786
54Arginine biosynthesis_Homo sapiens_hsa002200.87176043
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85821952
56Mismatch repair_Homo sapiens_hsa034300.84620450
57FoxO signaling pathway_Homo sapiens_hsa040680.82271812
58Synaptic vesicle cycle_Homo sapiens_hsa047210.78191080
59Pyruvate metabolism_Homo sapiens_hsa006200.75094966
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71879919
61Hippo signaling pathway_Homo sapiens_hsa043900.69034909
62Ras signaling pathway_Homo sapiens_hsa040140.68879979
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68492483
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63307251
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.61526798
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60605982
67DNA replication_Homo sapiens_hsa030300.60333388
68Wnt signaling pathway_Homo sapiens_hsa043100.60300453
69Non-small cell lung cancer_Homo sapiens_hsa052230.59750242
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57660475
71Circadian entrainment_Homo sapiens_hsa047130.56649552
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55677006
73Nucleotide excision repair_Homo sapiens_hsa034200.55373430
74mRNA surveillance pathway_Homo sapiens_hsa030150.55175454
75Gap junction_Homo sapiens_hsa045400.54966168
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54379578
77Regulation of autophagy_Homo sapiens_hsa041400.52970067
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50486731
79Endometrial cancer_Homo sapiens_hsa052130.49688349
80Adherens junction_Homo sapiens_hsa045200.48965003
81Insulin secretion_Homo sapiens_hsa049110.47717981
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47699901
83Estrogen signaling pathway_Homo sapiens_hsa049150.46944204
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46451498
85Bladder cancer_Homo sapiens_hsa052190.46097501
86Purine metabolism_Homo sapiens_hsa002300.46030390
87Complement and coagulation cascades_Homo sapiens_hsa046100.45765289
88HTLV-I infection_Homo sapiens_hsa051660.45455688
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45013771
90Thyroid cancer_Homo sapiens_hsa052160.44217628
91Glioma_Homo sapiens_hsa052140.43937018
92Glutamatergic synapse_Homo sapiens_hsa047240.42832825
93Huntingtons disease_Homo sapiens_hsa050160.42174618
94Histidine metabolism_Homo sapiens_hsa003400.42074386
95Arachidonic acid metabolism_Homo sapiens_hsa005900.41901350
96Long-term potentiation_Homo sapiens_hsa047200.40240065
97Serotonergic synapse_Homo sapiens_hsa047260.39114427
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.39004837
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37584471
100Chronic myeloid leukemia_Homo sapiens_hsa052200.37041049
101Cholinergic synapse_Homo sapiens_hsa047250.36416442
102Tyrosine metabolism_Homo sapiens_hsa003500.36269469
103Phagosome_Homo sapiens_hsa041450.35417844
104Herpes simplex infection_Homo sapiens_hsa051680.35239403
105Small cell lung cancer_Homo sapiens_hsa052220.34544003
106Arginine and proline metabolism_Homo sapiens_hsa003300.33528622
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.31949486
108Calcium signaling pathway_Homo sapiens_hsa040200.31867481
109MAPK signaling pathway_Homo sapiens_hsa040100.28994555
110Protein digestion and absorption_Homo sapiens_hsa049740.28737471
111Dopaminergic synapse_Homo sapiens_hsa047280.28465013
112Melanoma_Homo sapiens_hsa052180.28026449
113ErbB signaling pathway_Homo sapiens_hsa040120.27199372
114Lysine degradation_Homo sapiens_hsa003100.26884500
115cAMP signaling pathway_Homo sapiens_hsa040240.26186111
116Amphetamine addiction_Homo sapiens_hsa050310.26171255
117Oxytocin signaling pathway_Homo sapiens_hsa049210.25821912
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25512455
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25019111
120Melanogenesis_Homo sapiens_hsa049160.24869151
121Vitamin digestion and absorption_Homo sapiens_hsa049770.24707647
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23645415
123Hepatitis B_Homo sapiens_hsa051610.23084307
124Insulin signaling pathway_Homo sapiens_hsa049100.22827816
125Salivary secretion_Homo sapiens_hsa049700.22770146
126Gastric acid secretion_Homo sapiens_hsa049710.22532931
127HIF-1 signaling pathway_Homo sapiens_hsa040660.22485337
128Notch signaling pathway_Homo sapiens_hsa043300.21987210
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20642590
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.19592660
131Prostate cancer_Homo sapiens_hsa052150.19249772
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18808743
133Other glycan degradation_Homo sapiens_hsa005110.18513308
134Tight junction_Homo sapiens_hsa045300.18335534
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18017146
136Cocaine addiction_Homo sapiens_hsa050300.17794438
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16798374
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16062991
139Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14227155
140Viral carcinogenesis_Homo sapiens_hsa052030.10896635

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