ZP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* multicellular organism reproduction (GO:0032504)9.91296496
2regulation of retinoic acid receptor signaling pathway (GO:0048385)9.64207426
3regulation of DNA methylation (GO:0044030)9.52596273
4citrulline biosynthetic process (GO:0019240)7.34513216
5meiotic cell cycle (GO:0051321)7.19738676
6* negative regulation of reproductive process (GO:2000242)7.18484006
7regulation of hypersensitivity (GO:0002883)7.00142152
8piRNA metabolic process (GO:0034587)6.98330959
9* reproduction (GO:0000003)6.56834269
10DNA methylation involved in gamete generation (GO:0043046)6.43780716
11female gamete generation (GO:0007292)6.26026289
12regulation of histone H3-K9 methylation (GO:0051570)6.11484648
13positive regulation of histone H3-K4 methylation (GO:0051571)6.10815585
14regulation of phospholipid biosynthetic process (GO:0071071)5.84540876
15* protein kinase C signaling (GO:0070528)5.72819172
16* binding of sperm to zona pellucida (GO:0007339)5.70008857
17regulation of steroid hormone secretion (GO:2000831)5.62557396
18positive regulation of inflammatory response to antigenic stimulus (GO:0002863)5.50754007
19mitotic chromosome condensation (GO:0007076)5.23794708
20negative regulation of histone methylation (GO:0031061)5.12767274
21retinal cone cell development (GO:0046549)5.10518323
22* fertilization (GO:0009566)4.95707718
23* positive regulation of humoral immune response (GO:0002922)4.93237000
24* positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.87754849
25regulation of meiosis I (GO:0060631)4.84072498
26regulation of acute inflammatory response to antigenic stimulus (GO:0002864)4.82839007
27glycine transport (GO:0015816)4.82642401
28* single fertilization (GO:0007338)4.73264019
29citrulline metabolic process (GO:0000052)4.49800828
30gene silencing by RNA (GO:0031047)4.47398178
31* sperm-egg recognition (GO:0035036)4.34373603
32histone H3-K9 demethylation (GO:0033169)4.24442704
33positive regulation of uterine smooth muscle contraction (GO:0070474)4.20560483
34N-terminal protein amino acid acetylation (GO:0006474)4.17338609
35* regulation of reproductive process (GO:2000241)4.07832694
36DNA alkylation (GO:0006305)4.00665860
37DNA methylation (GO:0006306)4.00665860
38* regulation of calcium ion-dependent exocytosis (GO:0017158)3.91782747
39positive regulation of mitotic sister chromatid separation (GO:1901970)3.89648685
40positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.89648685
41positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.89648685
42protein localization to chromosome, centromeric region (GO:0071459)3.86813932
43regulation of steroid hormone biosynthetic process (GO:0090030)3.83655548
44regulation of cell maturation (GO:1903429)3.83496387
45regulation of histone H3-K4 methylation (GO:0051569)3.82289632
46positive regulation of gastrulation (GO:2000543)3.79466423
47* positive regulation of reproductive process (GO:2000243)3.78796223
48positive regulation of histone methylation (GO:0031062)3.78595527
49protein localization to kinetochore (GO:0034501)3.77104701
50positive regulation of interleukin-4 production (GO:0032753)3.69567713
51positive regulation of chromosome segregation (GO:0051984)3.62643189
52peptidyl-arginine modification (GO:0018195)3.62230016
53attachment of spindle microtubules to kinetochore (GO:0008608)3.57781560
54stress granule assembly (GO:0034063)3.55870496
55hyperosmotic salinity response (GO:0042538)3.52441641
56regulation of spindle organization (GO:0090224)3.50795526
57phosphatidylinositol dephosphorylation (GO:0046856)3.48952090
58interkinetic nuclear migration (GO:0022027)3.47750943
59mitotic metaphase plate congression (GO:0007080)3.47096422
60male meiosis I (GO:0007141)3.46794707
61* cell-cell recognition (GO:0009988)3.46348697
62phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.46072818
63regulation of cytokine production involved in inflammatory response (GO:1900015)3.41650886
64regulation of histone methylation (GO:0031060)3.39166264
65primitive streak formation (GO:0090009)3.38105479
66regulation of chromatin silencing (GO:0031935)3.33804988
67negative regulation of histone modification (GO:0031057)3.30924009
68regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.30801409
69regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.29446775
70regulation of meiosis (GO:0040020)3.29200149
71gene silencing (GO:0016458)3.28452152
72regulation of chromatin binding (GO:0035561)3.26952276
73phosphorelay signal transduction system (GO:0000160)3.25881646
74phospholipid dephosphorylation (GO:0046839)3.24775447
75aggressive behavior (GO:0002118)3.22924950
76type B pancreatic cell development (GO:0003323)3.21823810
77histone lysine demethylation (GO:0070076)3.20830153
78L-amino acid import (GO:0043092)3.17955674
79regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.16545847
80regulation of uterine smooth muscle contraction (GO:0070472)3.14603328
81synaptonemal complex assembly (GO:0007130)3.14384036
82meiosis I (GO:0007127)3.11170255
83DNA replication checkpoint (GO:0000076)3.09811853
84immunoglobulin mediated immune response (GO:0016064)3.06857782
85histone demethylation (GO:0016577)3.06407890
86regulation of cell cycle G2/M phase transition (GO:1902749)3.05483606
87establishment of chromosome localization (GO:0051303)3.04545864
88positive regulation of hormone biosynthetic process (GO:0046886)3.04273462
89positive regulation of calcium ion import (GO:0090280)3.04246984
90synapsis (GO:0007129)3.04020754
91negative regulation of hormone biosynthetic process (GO:0032353)3.03840698
92histone phosphorylation (GO:0016572)3.00843142
93positive regulation of meiosis (GO:0045836)2.99528312
94regulation of female receptivity (GO:0045924)2.99022142
95positive regulation of DNA-dependent DNA replication (GO:2000105)2.97718261
96DNA replication-dependent nucleosome assembly (GO:0006335)2.97219640
97regulation of female gonad development (GO:2000194)13.9998982
98* regulation of acrosome reaction (GO:0060046)11.8496196
99oocyte development (GO:0048599)11.5583248
100negative regulation of retinoic acid receptor signaling pathway (GO:0048387)11.4233840

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.27291154
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.79117335
3E2F7_22180533_ChIP-Seq_HELA_Human2.76102702
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.65159999
5NOTCH1_21737748_ChIP-Seq_TLL_Human2.64705196
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.51607438
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.51607438
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.51607438
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.42681109
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38571230
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.12670039
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.11236235
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07540684
14EZH2_22144423_ChIP-Seq_EOC_Human18.9036815
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.93845017
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93395136
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76731812
18AR_21909140_ChIP-Seq_LNCAP_Human1.50602290
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49852067
20GATA1_26923725_Chip-Seq_HPCs_Mouse1.35937543
21HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34977373
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29797370
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28926741
24GBX2_23144817_ChIP-Seq_PC3_Human1.25951938
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24180189
26CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18625717
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09603938
28EP300_21415370_ChIP-Seq_HL-1_Mouse1.07136252
29NANOG_20526341_ChIP-Seq_ESCs_Human1.04882769
30CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04069189
31GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99707388
32STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98598636
33KLF4_19829295_ChIP-Seq_ESCs_Human0.95481717
34GF1_26923725_Chip-Seq_HPCs_Mouse0.93737412
35TCF4_23295773_ChIP-Seq_U87_Human0.93580445
36OCT4_19829295_ChIP-Seq_ESCs_Human0.93333444
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92463643
38PRDM14_20953172_ChIP-Seq_ESCs_Human0.91709444
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91452766
40TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90466390
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90454051
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88900756
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88600921
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88600921
45BP1_19119308_ChIP-ChIP_Hs578T_Human0.86315123
46LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85557604
47ZNF274_21170338_ChIP-Seq_K562_Hela0.84580694
48LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83473388
49* SMAD4_21741376_ChIP-Seq_EPCs_Human0.81893965
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.81814178
51AR_25329375_ChIP-Seq_VCAP_Human0.80147249
52SMAD4_21799915_ChIP-Seq_A2780_Human0.79214661
53* FOXH1_21741376_ChIP-Seq_EPCs_Human0.78487540
54EZH2_27304074_Chip-Seq_ESCs_Mouse0.74720826
55BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.73814343
56CREB1_15753290_ChIP-ChIP_HEK293T_Human0.73239974
57* RUNX2_22187159_ChIP-Seq_PCA_Human0.73136117
58CBP_21632823_ChIP-Seq_H3396_Human0.72321552
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.70860441
60CBP_20019798_ChIP-Seq_JUKART_Human0.70860441
61P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.69252776
62FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.67271061
63SMRT_27268052_Chip-Seq_Bcells_Human0.66484213
64NANOG_18555785_ChIP-Seq_MESCs_Mouse0.65294520
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.62038132
66AUTS2_25519132_ChIP-Seq_293T-REX_Human0.61575126
67TP53_22573176_ChIP-Seq_HFKS_Human0.61351533
68STAT3_23295773_ChIP-Seq_U87_Human0.61318121
69CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.61066375
70PKCTHETA_26484144_Chip-Seq_BREAST_Human0.60391578
71IRF1_19129219_ChIP-ChIP_H3396_Human0.60309962
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.60285840
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.60077532
74ESR1_15608294_ChIP-ChIP_MCF-7_Human0.58980929
75SALL4_22934838_ChIP-ChIP_CD34+_Human0.58387542
76MYC_18940864_ChIP-ChIP_HL60_Human0.58102770
77BMI1_23680149_ChIP-Seq_NPCS_Mouse0.57858012
78FOXP3_21729870_ChIP-Seq_TREG_Human0.57515743
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.57446817
80* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.56866539
81REST_21632747_ChIP-Seq_MESCs_Mouse0.56558139
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.56442483
83KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.56035338
84RXR_22108803_ChIP-Seq_LS180_Human0.55442320
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.55338147
86E2F1_17053090_ChIP-ChIP_MCF-7_Human0.54304600
87NCOR_22424771_ChIP-Seq_293T_Human0.54100059
88FOXM1_26456572_ChIP-Seq_MCF-7_Human0.53887514
89* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.53886375
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.53505328
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.52838040
92NR3C1_23031785_ChIP-Seq_PC12_Mouse0.51890864
93OCT4_20526341_ChIP-Seq_ESCs_Human0.51349963
94* SMAD3_21741376_ChIP-Seq_EPCs_Human0.51123012
95YY1_21170310_ChIP-Seq_MESCs_Mouse0.51092970
96* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.50900740
97CTCF_21964334_Chip-Seq_Bcells_Human0.49368399
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.48787989
99GATA3_26560356_Chip-Seq_TH1_Human0.48772966
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.48313355

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect9.34680034
2MP0006292_abnormal_olfactory_placode4.44403257
3MP0008877_abnormal_DNA_methylation3.84092826
4MP0005395_other_phenotype3.74222836
5MP0003699_abnormal_female_reproductive3.22014655
6MP0008789_abnormal_olfactory_epithelium3.13179925
7MP0005499_abnormal_olfactory_system2.98653688
8MP0005394_taste/olfaction_phenotype2.98653688
9MP0003693_abnormal_embryo_hatching2.93320358
10MP0001929_abnormal_gametogenesis2.82019098
11MP0008057_abnormal_DNA_replication2.77613897
12MP0002139_abnormal_hepatobiliary_system2.60693949
13MP0003890_abnormal_embryonic-extraembry2.53037816
14MP0005360_urolithiasis2.35129396
15MP0002138_abnormal_hepatobiliary_system2.32798514
16MP0010030_abnormal_orbit_morphology2.28800967
17MP0002210_abnormal_sex_determination2.20270857
18MP0009840_abnormal_foam_cell2.17981271
19MP0003879_abnormal_hair_cell2.15334347
20MP0001119_abnormal_female_reproductive2.14030597
21MP0003950_abnormal_plasma_membrane2.13021192
22MP0000653_abnormal_sex_gland1.97679882
23MP0002161_abnormal_fertility/fecundity1.96218954
24MP0003077_abnormal_cell_cycle1.94483345
25MP0010368_abnormal_lymphatic_system1.90098590
26MP0000566_synostosis1.89885411
27MP0008058_abnormal_DNA_repair1.83547254
28MP0001730_embryonic_growth_arrest1.81305635
29MP0003111_abnormal_nucleus_morphology1.72736670
30MP0010307_abnormal_tumor_latency1.70740967
31MP0010234_abnormal_vibrissa_follicle1.67099392
32MP0005410_abnormal_fertilization1.66442051
33MP0005389_reproductive_system_phenotype1.66349676
34MP0010094_abnormal_chromosome_stability1.59709045
35MP0002234_abnormal_pharynx_morphology1.57202994
36MP0001986_abnormal_taste_sensitivity1.50368094
37MP0001919_abnormal_reproductive_system1.39557498
38MP0002160_abnormal_reproductive_system1.35218513
39MP0003183_abnormal_peptide_metabolism1.33543415
40MP0003121_genomic_imprinting1.32853474
41MP0005380_embryogenesis_phenotype1.32528006
42MP0001672_abnormal_embryogenesis/_devel1.32528006
43MP0000631_abnormal_neuroendocrine_gland1.30923081
44MP0009379_abnormal_foot_pigmentation1.23926139
45MP0005646_abnormal_pituitary_gland1.23684047
46MP0008932_abnormal_embryonic_tissue1.23339284
47MP0005647_abnormal_sex_gland1.14094074
48MP0001145_abnormal_male_reproductive1.11205529
49MP0001293_anophthalmia1.05399217
50MP0000762_abnormal_tongue_morphology1.04125821
51MP0000427_abnormal_hair_cycle1.03033237
52MP0002233_abnormal_nose_morphology1.03016033
53MP0003698_abnormal_male_reproductive0.99819156
54MP0001664_abnormal_digestion0.99801539
55MP0003252_abnormal_bile_duct0.99125566
56MP0001666_abnormal_nutrient_absorption0.97584062
57MP0000350_abnormal_cell_proliferation0.95175969
58MP0006276_abnormal_autonomic_nervous0.94316582
59MP0003119_abnormal_digestive_system0.92803124
60MP0004142_abnormal_muscle_tone0.88112117
61MP0010678_abnormal_skin_adnexa0.86773074
62MP0000678_abnormal_parathyroid_gland0.85574709
63MP0003136_yellow_coat_color0.80792434
64MP0004957_abnormal_blastocyst_morpholog0.80582687
65MP0002272_abnormal_nervous_system0.79213487
66MP0002127_abnormal_cardiovascular_syste0.78974632
67MP0003959_abnormal_lean_body0.78911082
68MP0000049_abnormal_middle_ear0.76819164
69MP0001502_abnormal_circadian_rhythm0.74743822
70MP0000733_abnormal_muscle_development0.72297638
71MP0002084_abnormal_developmental_patter0.70533702
72MP0003868_abnormal_feces_composition0.68945569
73MP0003941_abnormal_skin_development0.64741910
74MP0005076_abnormal_cell_differentiation0.64201313
75MP0002089_abnormal_postnatal_growth/wei0.63343897
76MP0005409_darkened_coat_color0.62791680
77MP0002085_abnormal_embryonic_tissue0.61133668
78MP0001324_abnormal_eye_pigmentation0.61010856
79MP0005085_abnormal_gallbladder_physiolo0.59630599
80MP0003984_embryonic_growth_retardation0.58931584
81MP0001963_abnormal_hearing_physiology0.57338300
82MP0001697_abnormal_embryo_size0.55998395
83MP0001984_abnormal_olfaction0.55132839
84MP0003646_muscle_fatigue0.54614536
85MP0005551_abnormal_eye_electrophysiolog0.54566162
86MP0002088_abnormal_embryonic_growth/wei0.53949952
87MP0000383_abnormal_hair_follicle0.52360242
88MP0005503_abnormal_tendon_morphology0.49618435
89MP0003935_abnormal_craniofacial_develop0.48996248
90MP0005423_abnormal_somatic_nervous0.48580993
91MP0001881_abnormal_mammary_gland0.45877481
92MP0000015_abnormal_ear_pigmentation0.45785960
93MP0002098_abnormal_vibrissa_morphology0.42428887
94MP0001545_abnormal_hematopoietic_system0.42325189
95MP0005397_hematopoietic_system_phenotyp0.42325189
96MP0002873_normal_phenotype0.42202204
97MP0002169_no_abnormal_phenotype0.41547076
98MP0005501_abnormal_skin_physiology0.40405253
99MP0003936_abnormal_reproductive_system0.40383310
100MP0000470_abnormal_stomach_morphology0.40374104

Predicted human phenotypes

RankGene SetZ-score
1Anterior segment dysgenesis (HP:0007700)6.87201573
2Hypoplasia of the fovea (HP:0007750)6.77249984
3Aplasia/Hypoplasia of the fovea (HP:0008060)6.77249984
4Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)6.05361469
5Abnormality of the fovea (HP:0000493)5.53825267
6Male infertility (HP:0003251)5.26977853
7Impulsivity (HP:0100710)5.17306798
8Abnormality of abdominal situs (HP:0011620)4.77024020
9Abdominal situs inversus (HP:0003363)4.77024020
10Infertility (HP:0000789)4.72135262
11Premature ovarian failure (HP:0008209)4.70330036
12Papillary thyroid carcinoma (HP:0002895)4.69535877
13Osteomalacia (HP:0002749)4.66602600
14Lip pit (HP:0100267)4.52997063
15Hypergonadotropic hypogonadism (HP:0000815)4.52667238
16Aplasia/Hypoplasia of the macula (HP:0008059)4.35106538
17Hypophosphatemic rickets (HP:0004912)4.14373731
18Aplasia/Hypoplasia affecting the retina (HP:0008061)4.00348489
19Cholecystitis (HP:0001082)3.83426233
20Abnormal gallbladder physiology (HP:0012438)3.83426233
21Secondary amenorrhea (HP:0000869)3.76670935
22Supernumerary spleens (HP:0009799)3.65945541
23Apathy (HP:0000741)3.62650978
24Malnutrition (HP:0004395)3.59999227
25Facial hemangioma (HP:0000329)3.45429858
26Diminished motivation (HP:0000745)3.43240682
27Chromosomal breakage induced by crosslinking agents (HP:0003221)3.32560871
28Chromsome breakage (HP:0040012)3.29569637
29Septo-optic dysplasia (HP:0100842)3.28753908
30Aplasia of the musculature (HP:0100854)3.16773440
31Azoospermia (HP:0000027)3.13712612
32Hypokinesia (HP:0002375)3.01606022
33Myokymia (HP:0002411)2.99008083
34Oligodactyly (hands) (HP:0001180)2.97867394
35Abnormality of the anterior chamber (HP:0000593)2.95598545
36Loss of speech (HP:0002371)2.73187917
37Pulmonary fibrosis (HP:0002206)2.72767266
38Gonadotropin excess (HP:0000837)2.71369804
39Truncal obesity (HP:0001956)2.68680657
40Absent septum pellucidum (HP:0001331)2.61070452
41Median cleft lip (HP:0000161)2.57101021
42Anhidrosis (HP:0000970)2.56707422
43Thyroid carcinoma (HP:0002890)2.50474283
44Skin pits (HP:0100276)2.45083710
45Urethral obstruction (HP:0000796)2.36963722
46Short tibia (HP:0005736)2.35978543
47Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.33823173
48Spinal cord compression (HP:0002176)2.33755802
49Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.33710308
50Abnormal spermatogenesis (HP:0008669)2.32282193
51Oligodactyly (HP:0012165)2.31222980
52Abnormality of the septum pellucidum (HP:0007375)2.31137393
53Neurofibrillary tangles (HP:0002185)2.30720472
54Metaphyseal irregularity (HP:0003025)2.29069596
55Lower limb hyperreflexia (HP:0002395)2.28352854
56Hypercortisolism (HP:0001578)2.28160171
57Capillary hemangiomas (HP:0005306)2.18687105
58Muscle stiffness (HP:0003552)2.15899233
59Supranuclear gaze palsy (HP:0000605)2.15032868
60Striae distensae (HP:0001065)2.11200864
61Congenital sensorineural hearing impairment (HP:0008527)2.08610598
62Aplasia/Hypoplasia involving the musculature (HP:0001460)2.07893234
63Abnormality of the labia minora (HP:0012880)2.05944041
64Increased circulating renin level (HP:0000848)2.05892787
65Aplasia/Hypoplasia of the tibia (HP:0005772)2.04668743
66Bundle branch block (HP:0011710)2.02828505
67Cone-rod dystrophy (HP:0000548)2.02473805
68Subcapsular cataract (HP:0000523)2.01464879
69Dysdiadochokinesis (HP:0002075)1.98813476
70Posterior embryotoxon (HP:0000627)1.95407958
71Primary amenorrhea (HP:0000786)1.91363659
72Conjunctival telangiectasia (HP:0000524)1.89515565
73Carpal bone hypoplasia (HP:0001498)1.83751766
74Abnormality of the line of Schwalbe (HP:0008048)1.83630312
75Maternal diabetes (HP:0009800)1.82548147
76Aplasia/Hypoplasia of the tongue (HP:0010295)1.82391937
77Abnormality of monocarboxylic acid metabolism (HP:0010996)1.81542455
78Proximal tubulopathy (HP:0000114)1.80717695
79Sensory axonal neuropathy (HP:0003390)1.78914545
80Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.78671943
81Intrahepatic cholestasis (HP:0001406)1.78618628
82Abnormality of the salivary glands (HP:0010286)1.75959394
83Cleft eyelid (HP:0000625)1.75500018
84Aplasia/Hypoplasia of the uvula (HP:0010293)1.73043694
85Preauricular pit (HP:0004467)1.73004142
86Periauricular skin pits (HP:0100277)1.73004142
87Meckel diverticulum (HP:0002245)1.71605191
88Abnormality of calcium-phosphate metabolism (HP:0100530)1.70354826
89Hydroureter (HP:0000072)1.67994818
90Posterior subcapsular cataract (HP:0007787)1.66492256
91Abnormality of the phalanges of the hallux (HP:0010057)1.65705578
92Rickets (HP:0002748)1.65676159
93Dysmetric saccades (HP:0000641)1.65072566
94Generalized aminoaciduria (HP:0002909)1.65021295
95Cranial hyperostosis (HP:0004437)1.64842135
96Abnormal lung lobation (HP:0002101)1.64471825
97Abnormality of the preputium (HP:0100587)1.64385359
98Abnormality of the ileum (HP:0001549)1.63272907
99Fair hair (HP:0002286)1.61904195
100Hyperactive renin-angiotensin system (HP:0000841)1.61538674

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K95.53031904
2CDK125.23241364
3ARAF4.81832800
4MAP3K134.75057697
5NEK62.99554119
6TTK2.83442295
7TAOK32.80927497
8STK242.71865683
9AURKA2.70348819
10BRAF2.29491002
11TRIM282.12108263
12MOS2.11709084
13MET2.07492090
14CDK91.81918438
15NTRK21.81028840
16MELK1.80855767
17BUB11.77399814
18CAMK1D1.77385061
19BRSK11.69426977
20CDC71.56600260
21KSR21.51680710
22CDK71.46655188
23CDK191.41498845
24TNIK1.38125274
25RAF11.37770169
26PLK11.37557496
27TESK21.34962091
28PRKCI1.33230732
29WNK11.28370513
30STK31.26543525
31PTK21.22347058
32CHEK11.20891127
33CAMK1G1.13998483
34BRD41.10260839
35EIF2AK30.99306777
36NEK20.95610463
37TGFBR10.94763027
38MTOR0.90953084
39ZAK0.90251471
40MAP3K80.88039506
41KSR10.87785138
42MARK30.85880125
43CSNK1G10.85779120
44PIM10.85684208
45CDK80.82937593
46CDK20.82605215
47AURKB0.80770980
48EEF2K0.80540441
49BRSK20.76190167
50NTRK30.74574115
51SRPK10.73993480
52CHEK20.73689525
53PAK10.68849959
54ATM0.64269321
55NME10.62894613
56TLK10.60505893
57MAPKAPK30.60388531
58PLK30.59024824
59CSNK1D0.58674462
60LATS20.57095721
61PKN10.56268870
62TNK20.55729647
63CDK10.54989014
64CSNK1G30.51934944
65LRRK20.49732172
66MAP3K50.49101661
67PRKCZ0.48964134
68MAPK110.48295699
69CSNK1E0.45612545
70BMPR1B0.43833129
71MST40.43767581
72AKT20.43407345
73PRKG10.39978391
74CDC42BPA0.39272720
75ATR0.38244911
76CDK50.37730067
77GSK3B0.37384961
78CAMK40.37077052
79STK390.35708829
80MAPK100.35119902
81MARK20.34475221
82NUAK10.33570592
83TIE10.33478286
84PDK10.32621874
85MAPK10.32155448
86PRKD30.31732349
87MAPK130.31609163
88CSNK1A1L0.30341529
89STK160.29191005
90CLK10.28595937
91DMPK0.25966375
92CSNK1G20.25657611
93STK100.25098916
94PBK0.24454461
95CAMK10.23899008
96MAP3K70.23897961
97PRKAA10.22953146
98PRKACB0.22102142
99MAPK140.21208143
100PRKACA0.20219158

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049135.43754073
2Basal transcription factors_Homo sapiens_hsa030225.10140859
3Cell cycle_Homo sapiens_hsa041104.05588103
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.35300421
5Oocyte meiosis_Homo sapiens_hsa041143.17137789
6Dorso-ventral axis formation_Homo sapiens_hsa043202.90341084
7Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.88250602
8Mismatch repair_Homo sapiens_hsa034302.79212365
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.39195706
10Base excision repair_Homo sapiens_hsa034102.32330431
11RNA degradation_Homo sapiens_hsa030182.31750104
12RNA transport_Homo sapiens_hsa030132.20825252
13Gap junction_Homo sapiens_hsa045401.97948628
14Cysteine and methionine metabolism_Homo sapiens_hsa002701.97256048
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.95405114
16DNA replication_Homo sapiens_hsa030301.95308958
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92092551
18mRNA surveillance pathway_Homo sapiens_hsa030151.85604091
19p53 signaling pathway_Homo sapiens_hsa041151.82822435
20Fanconi anemia pathway_Homo sapiens_hsa034601.78158575
21RNA polymerase_Homo sapiens_hsa030201.72272782
22Inositol phosphate metabolism_Homo sapiens_hsa005621.65975288
23Nucleotide excision repair_Homo sapiens_hsa034201.65742557
24Caffeine metabolism_Homo sapiens_hsa002321.62659933
25Circadian rhythm_Homo sapiens_hsa047101.60926322
26Olfactory transduction_Homo sapiens_hsa047401.52771890
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43972255
28Homologous recombination_Homo sapiens_hsa034401.34146284
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30657605
30Thyroid cancer_Homo sapiens_hsa052161.30440014
31Folate biosynthesis_Homo sapiens_hsa007901.29418219
32mTOR signaling pathway_Homo sapiens_hsa041501.12533276
33Taste transduction_Homo sapiens_hsa047421.11640360
34Lysine degradation_Homo sapiens_hsa003101.06943617
35TGF-beta signaling pathway_Homo sapiens_hsa043501.02124136
36ABC transporters_Homo sapiens_hsa020101.00931105
37Phototransduction_Homo sapiens_hsa047440.97391081
38Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94168786
39Bile secretion_Homo sapiens_hsa049760.92237556
40GABAergic synapse_Homo sapiens_hsa047270.85764335
41MicroRNAs in cancer_Homo sapiens_hsa052060.83380274
42Adherens junction_Homo sapiens_hsa045200.79947688
43Regulation of autophagy_Homo sapiens_hsa041400.77441093
44Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70776234
45Wnt signaling pathway_Homo sapiens_hsa043100.68712074
46Morphine addiction_Homo sapiens_hsa050320.67489724
47FoxO signaling pathway_Homo sapiens_hsa040680.67428329
48Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63419338
49Herpes simplex infection_Homo sapiens_hsa051680.57925482
50Nicotine addiction_Homo sapiens_hsa050330.57892083
51Notch signaling pathway_Homo sapiens_hsa043300.55594609
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55424779
53Serotonergic synapse_Homo sapiens_hsa047260.55328758
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54689877
55Viral carcinogenesis_Homo sapiens_hsa052030.48980242
56Protein digestion and absorption_Homo sapiens_hsa049740.47794788
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46109492
58Purine metabolism_Homo sapiens_hsa002300.45723722
59Fatty acid elongation_Homo sapiens_hsa000620.44624873
60Hippo signaling pathway_Homo sapiens_hsa043900.44274432
61Huntingtons disease_Homo sapiens_hsa050160.43684471
62Long-term depression_Homo sapiens_hsa047300.41726694
63Spliceosome_Homo sapiens_hsa030400.38812931
64Small cell lung cancer_Homo sapiens_hsa052220.37093869
65Synaptic vesicle cycle_Homo sapiens_hsa047210.35095440
66Arginine biosynthesis_Homo sapiens_hsa002200.34971096
67ErbB signaling pathway_Homo sapiens_hsa040120.33127079
68Ras signaling pathway_Homo sapiens_hsa040140.32325736
69HIF-1 signaling pathway_Homo sapiens_hsa040660.28461131
70Vitamin digestion and absorption_Homo sapiens_hsa049770.26215859
71Phagosome_Homo sapiens_hsa041450.25926163
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.25180160
73Pyrimidine metabolism_Homo sapiens_hsa002400.24140019
74Amoebiasis_Homo sapiens_hsa051460.23312181
75Influenza A_Homo sapiens_hsa051640.22929240
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22834350
77Renal cell carcinoma_Homo sapiens_hsa052110.22743604
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21980143
79Prostate cancer_Homo sapiens_hsa052150.21546742
80Insulin secretion_Homo sapiens_hsa049110.20416167
81Cholinergic synapse_Homo sapiens_hsa047250.20134135
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.19916038
83cAMP signaling pathway_Homo sapiens_hsa040240.19204470
84Melanogenesis_Homo sapiens_hsa049160.18449695
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18172126
86HTLV-I infection_Homo sapiens_hsa051660.17434204
87Endometrial cancer_Homo sapiens_hsa052130.16557753
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.16453945
89Long-term potentiation_Homo sapiens_hsa047200.16204290
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15666063
91Tight junction_Homo sapiens_hsa045300.15517846
92Arginine and proline metabolism_Homo sapiens_hsa003300.15390059
93Circadian entrainment_Homo sapiens_hsa047130.15187239
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13745402
95Pathways in cancer_Homo sapiens_hsa052000.13701587
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.13218514
97Oxytocin signaling pathway_Homo sapiens_hsa049210.12106482
98Insulin signaling pathway_Homo sapiens_hsa049100.10982884
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.10638282
100MAPK signaling pathway_Homo sapiens_hsa040100.10532428

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