ZPBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ZPBP is one of several proteins that are thought to participate in secondary binding between acrosome-reacted sperm and the egg-specific extracellular matrix, the zona pellucida (McLeskey et al., 1998 [PubMed 9378618]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.99137967
2axonemal dynein complex assembly (GO:0070286)9.89556399
3* binding of sperm to zona pellucida (GO:0007339)9.73491501
4reproduction (GO:0000003)9.69185241
5male meiosis (GO:0007140)9.38351183
6spermatid development (GO:0007286)8.92339123
7piRNA metabolic process (GO:0034587)8.81701878
8epithelial cilium movement (GO:0003351)8.66615734
9synaptonemal complex organization (GO:0070193)8.27730476
10synaptonemal complex assembly (GO:0007130)8.24325816
11motile cilium assembly (GO:0044458)8.02740431
12regulation of cilium movement (GO:0003352)7.93519183
13cilium movement (GO:0003341)7.90240043
14sperm capacitation (GO:0048240)7.80782644
15single fertilization (GO:0007338)7.52547632
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.39097077
17tyrosine phosphorylation of STAT protein (GO:0007260)7.01266482
18rRNA methylation (GO:0031167)7.00867478
19fertilization (GO:0009566)6.27198469
20chromosome organization involved in meiosis (GO:0070192)5.92326192
21microtubule nucleation (GO:0007020)5.86219234
22spermatogenesis (GO:0007283)5.74020688
23rRNA modification (GO:0000154)5.72818919
24male gamete generation (GO:0048232)5.72076431
25sexual reproduction (GO:0019953)5.67226326
26DNA methylation involved in gamete generation (GO:0043046)5.66250902
27male meiosis I (GO:0007141)5.63231339
28ventricular system development (GO:0021591)5.56648069
29microtubule severing (GO:0051013)5.52034081
30negative regulation of Rho protein signal transduction (GO:0035024)5.51621351
31negative regulation of inclusion body assembly (GO:0090084)5.50131354
32organic cation transport (GO:0015695)5.35940954
33meiotic nuclear division (GO:0007126)5.35251313
34gamete generation (GO:0007276)5.25231953
35* cellular process involved in reproduction in multicellular organism (GO:0022412)5.14313796
36germ cell development (GO:0007281)5.02930046
37spermatid nucleus differentiation (GO:0007289)4.97045878
38* cell recognition (GO:0008037)4.84055692
39protein-chromophore linkage (GO:0018298)4.74726029
40protein polyglutamylation (GO:0018095)4.73378909
41monoubiquitinated protein deubiquitination (GO:0035520)4.66183610
42seminiferous tubule development (GO:0072520)4.64793909
43calcium ion-dependent exocytosis (GO:0017156)4.61938808
44regulation of microtubule-based movement (GO:0060632)4.59367733
45meiosis I (GO:0007127)4.51643440
46single strand break repair (GO:0000012)4.46655436
47regulation of inclusion body assembly (GO:0090083)4.44187491
48microtubule depolymerization (GO:0007019)4.39680594
49establishment of protein localization to Golgi (GO:0072600)4.31559101
50protein localization to cilium (GO:0061512)4.25443208
51protein targeting to Golgi (GO:0000042)4.23091333
52regulation of sequestering of triglyceride (GO:0010889)4.22352766
53positive regulation of uterine smooth muscle contraction (GO:0070474)4.17653987
54multicellular organismal reproductive process (GO:0048609)4.09972642
55positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.09242981
56retrograde transport, vesicle recycling within Golgi (GO:0000301)3.99439613
57sulfur amino acid catabolic process (GO:0000098)3.98196922
58positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.95326458
59synapsis (GO:0007129)3.88805781
60tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.85487016
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.85487016
62genitalia morphogenesis (GO:0035112)3.83223985
63regulation of plasminogen activation (GO:0010755)3.78401562
64regulation of phosphoprotein phosphatase activity (GO:0043666)3.72803486
65homocysteine metabolic process (GO:0050667)3.69356906
66protein localization to Golgi apparatus (GO:0034067)3.68848002
67epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.65032159
68meiotic cell cycle (GO:0051321)3.62890318
69intraciliary transport (GO:0042073)3.62517659
70left/right pattern formation (GO:0060972)3.56162366
71positive regulation of mast cell degranulation (GO:0043306)3.50299516
72positive regulation of mast cell activation involved in immune response (GO:0033008)3.50299516
73cochlea development (GO:0090102)3.49291038
74chromosome condensation (GO:0030261)3.43459857
75inner ear receptor cell development (GO:0060119)3.42131831
76cysteine metabolic process (GO:0006534)3.41895213
77negative regulation of organelle assembly (GO:1902116)3.39827735
78negative regulation of cell cycle arrest (GO:0071157)3.39539679
79meiotic cell cycle process (GO:1903046)3.38963048
80gene silencing by RNA (GO:0031047)3.38608019
81DNA packaging (GO:0006323)3.34839534
82carnitine transmembrane transport (GO:1902603)3.33500553
83glycerol ether metabolic process (GO:0006662)3.31978925
84multicellular organismal development (GO:0007275)3.31603602
85regulation of centriole replication (GO:0046599)3.31567614
86amino-acid betaine transport (GO:0015838)3.31562135
87carnitine transport (GO:0015879)3.31562135
88adenosine metabolic process (GO:0046085)3.30084038
89regulation of transcription involved in cell fate commitment (GO:0060850)3.27643887
90alternative mRNA splicing, via spliceosome (GO:0000380)3.24613883
91microtubule polymerization or depolymerization (GO:0031109)3.23645734
92peptidyl-lysine dimethylation (GO:0018027)3.22071233
93regulation of uterine smooth muscle contraction (GO:0070472)3.21453205
94chaperone-mediated protein complex assembly (GO:0051131)3.20598771
95regulation of spindle checkpoint (GO:0090231)3.19009229
96phosphatidylethanolamine biosynthetic process (GO:0006646)3.12430022
97ether metabolic process (GO:0018904)3.04785180
98nuclear pore complex assembly (GO:0051292)3.04381514
99polyamine biosynthetic process (GO:0006596)3.03079265
100desmosome organization (GO:0002934)2.99664082
101microtubule-based movement (GO:0007018)2.98772062
102artery smooth muscle contraction (GO:0014824)2.98244261
103positive regulation of endothelial cell differentiation (GO:0045603)2.98081947
104folic acid-containing compound biosynthetic process (GO:0009396)2.94410299
105cilium organization (GO:0044782)2.92134742
106regulation of gene silencing by RNA (GO:0060966)2.88721384
107regulation of posttranscriptional gene silencing (GO:0060147)2.88721384
108regulation of gene silencing by miRNA (GO:0060964)2.88721384
109lactate metabolic process (GO:0006089)2.88563446
110centriole replication (GO:0007099)2.86992670
111regulation of inositol phosphate biosynthetic process (GO:0010919)2.85665736
112histone H3-K9 methylation (GO:0051567)2.85163235
113negative regulation of smooth muscle cell migration (GO:0014912)2.84333002
114negative regulation of stress fiber assembly (GO:0051497)2.80356733
115positive regulation of macrophage activation (GO:0043032)2.79693997
116cardiac right ventricle morphogenesis (GO:0003215)2.78260261
117positive regulation of mast cell activation (GO:0033005)2.78229351
118phosphatidylethanolamine metabolic process (GO:0046337)2.77913015
119regulation of gonadotropin secretion (GO:0032276)2.73277995
120regulation of hippo signaling (GO:0035330)2.73149837
121protein K11-linked deubiquitination (GO:0035871)2.72604158
122cilium assembly (GO:0042384)2.71025464
123tonic smooth muscle contraction (GO:0014820)2.70821698
124primary amino compound metabolic process (GO:1901160)2.70516064
125axoneme assembly (GO:0035082)2.70291767
126protein refolding (GO:0042026)2.70059335
127gamma-aminobutyric acid signaling pathway (GO:0007214)2.69585693
128nucleus organization (GO:0006997)2.68761768
129centriole assembly (GO:0098534)2.68388410
130peptidyl-glutamic acid modification (GO:0018200)2.68122555
131early endosome to late endosome transport (GO:0045022)2.67892340
132detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.67694247
133regulation of response to food (GO:0032095)2.66323983
134mitotic sister chromatid cohesion (GO:0007064)2.66016016
135negative regulation of keratinocyte proliferation (GO:0010839)2.65559425
136cellular extravasation (GO:0045123)2.64395596
137innervation (GO:0060384)2.62943071
138histone H3-K9 modification (GO:0061647)2.62620683
139histone exchange (GO:0043486)2.62537579
140* cellular component assembly involved in morphogenesis (GO:0010927)2.54405615
141sequestering of actin monomers (GO:0042989)2.52982181
142DNA replication-dependent nucleosome organization (GO:0034723)2.52981299
143DNA replication-dependent nucleosome assembly (GO:0006335)2.52981299
144gene silencing (GO:0016458)2.50201013
145cilium morphogenesis (GO:0060271)2.45269142
146calcium ion import (GO:0070509)2.45160678
147quaternary ammonium group transport (GO:0015697)2.43761066
148negative regulation of DNA repair (GO:0045738)2.42618897
149negative regulation of necroptotic process (GO:0060546)2.42590655
150interferon-gamma secretion (GO:0072643)2.35844934
151cilium or flagellum-dependent cell motility (GO:0001539)13.2293920
152fusion of sperm to egg plasma membrane (GO:0007342)13.1199508
153cell wall macromolecule catabolic process (GO:0016998)12.2886269
154cell wall macromolecule metabolic process (GO:0044036)12.2886269
155sperm motility (GO:0030317)11.9798263
156multicellular organism reproduction (GO:0032504)11.9454752
157* sperm-egg recognition (GO:0035036)11.5026634
158* acrosome assembly (GO:0001675)10.9570938
159* cell-cell recognition (GO:0009988)10.3321174
160acrosome reaction (GO:0007340)10.2517187

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.92685342
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.26993485
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.27116363
4GBX2_23144817_ChIP-Seq_PC3_Human3.63155752
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.62780334
6EZH2_22144423_ChIP-Seq_EOC_Human3.58473393
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.66813315
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.63788181
9FUS_26573619_Chip-Seq_HEK293_Human2.43351649
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.40580459
11* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.37016526
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.34189190
13* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.34049122
14* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.33842400
15ER_23166858_ChIP-Seq_MCF-7_Human2.13796311
16UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.03531709
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.1571475
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94986450
19ZNF274_21170338_ChIP-Seq_K562_Hela1.91863718
20P300_19829295_ChIP-Seq_ESCs_Human1.91317306
21PCGF2_27294783_Chip-Seq_NPCs_Mouse1.91076316
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89847299
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82249571
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.78536414
25TOP2B_26459242_ChIP-Seq_MCF-7_Human1.77699589
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75182532
27KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.73080741
28TAF15_26573619_Chip-Seq_HEK293_Human1.70968432
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.70301906
30* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.69350442
31RUNX2_22187159_ChIP-Seq_PCA_Human1.67507090
32FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66345149
33SMAD4_21799915_ChIP-Seq_A2780_Human1.65883873
34* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.64864279
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62935387
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.62191587
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60916824
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60235318
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.60235318
40AR_25329375_ChIP-Seq_VCAP_Human1.59375651
41KAP1_22055183_ChIP-Seq_ESCs_Mouse1.59183835
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.56875678
43GATA3_21867929_ChIP-Seq_CD8_Mouse1.56064464
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53347899
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53154063
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53014141
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52695326
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.52228942
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.52053471
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.51596060
51ELK4_26923725_Chip-Seq_MESODERM_Mouse1.51125004
52TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.50417595
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48519273
54DROSHA_22980978_ChIP-Seq_HELA_Human1.48320251
55* STAT3_23295773_ChIP-Seq_U87_Human1.47955002
56* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.47699135
57STAT1_17558387_ChIP-Seq_HELA_Human1.47654962
58CBP_20019798_ChIP-Seq_JUKART_Human1.45732419
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45732419
60SMAD4_21741376_ChIP-Seq_EPCs_Human1.45301531
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.45154981
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44998315
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.42843167
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41619470
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39878252
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39087398
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.37578562
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36258108
69VDR_22108803_ChIP-Seq_LS180_Human1.35760912
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35525658
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34085067
72TAL1_26923725_Chip-Seq_HPCs_Mouse1.33895898
73CDX2_22108803_ChIP-Seq_LS180_Human1.33840574
74SOX2_22085726_ChIP-Seq_NPCs_Mouse1.33696545
75OCT4_18555785_Chip-Seq_ESCs_Mouse1.32391976
76SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31285504
77GATA3_21867929_ChIP-Seq_TH1_Mouse1.30001599
78RUNX1_26923725_Chip-Seq_HPCs_Mouse1.26176273
79* FLI1_21867929_ChIP-Seq_TH2_Mouse1.25868972
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25681870
81RNF2_27304074_Chip-Seq_NSC_Mouse1.25201794
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24850810
83ESRRB_18555785_Chip-Seq_ESCs_Mouse1.24035154
84REST_21632747_ChIP-Seq_MESCs_Mouse1.22976052
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.22497235
86WDR5_24793694_ChIP-Seq_LNCAP_Human1.22378884
87AHR_22903824_ChIP-Seq_MCF-7_Human1.21935156
88* KDM2B_26808549_Chip-Seq_REH_Human1.21533796
89TCF4_23295773_ChIP-Seq_U87_Human1.20785032
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20346031
91MYC_19829295_ChIP-Seq_ESCs_Human1.19263217
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.18746069
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.18458276
94TBL1_22424771_ChIP-Seq_293T_Human1.18207581
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17926140
96KLF4_18555785_Chip-Seq_ESCs_Mouse1.17579674
97P300_18555785_Chip-Seq_ESCs_Mouse1.17327964
98OCT4_20526341_ChIP-Seq_ESCs_Human1.17250174
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16808423
100SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16242716
101BCAT_22108803_ChIP-Seq_LS180_Human1.16151475
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15978125
103* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.15714641
104RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14390280
105EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14390280
106P53_22387025_ChIP-Seq_ESCs_Mouse1.13153353
107SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12448802
108FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11719082
109SPI1_26923725_Chip-Seq_HPCs_Mouse1.11532962
110SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11061814
111STAT3_18555785_Chip-Seq_ESCs_Mouse1.09796811
112NFYB_21822215_ChIP-Seq_K562_Human1.09786762
113CMYC_18555785_Chip-Seq_ESCs_Mouse1.09783297
114CTCF_18555785_Chip-Seq_ESCs_Mouse1.09599655
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09457118
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09234456
117IGF1R_20145208_ChIP-Seq_DFB_Human1.09209861
118SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09163041
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08901721
120EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08685661
121GF1_26923725_Chip-Seq_HPCs_Mouse1.08548937
122PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08425888
123SMAD3_21741376_ChIP-Seq_ESCs_Human1.08410483
124P53_21459846_ChIP-Seq_SAOS-2_Human1.08237084
125SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.08110668
126* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07873838
127SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07069983
128BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06698153
129ELF1_20517297_ChIP-Seq_JURKAT_Human1.06538576
130SMAD4_21741376_ChIP-Seq_HESCs_Human1.06377878
131OCT1_27270436_Chip-Seq_PROSTATE_Human1.06097434
132NANOG_19829295_ChIP-Seq_ESCs_Human1.05827334
133SOX2_19829295_ChIP-Seq_ESCs_Human1.05827334
134AR_21572438_ChIP-Seq_LNCaP_Human1.04770103
135RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04704061
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04423408
137TCF4_22108803_ChIP-Seq_LS180_Human1.04189846
138* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03526515
139NCOR_22424771_ChIP-Seq_293T_Human1.03133704
140LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02756880
141CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01858239
142CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01620240
143* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01415003
144ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01403242
145MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00862670
146CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00491463
147FOXH1_21741376_ChIP-Seq_ESCs_Human1.00462144
148CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00395482
149MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00306191
150RARA_24833708_ChIP-Seq_LIVER_Mouse1.00274857
151ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99543887
152EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99119073
153FOXH1_21741376_ChIP-Seq_EPCs_Human0.98901211
154TP53_18474530_ChIP-ChIP_U2OS_Human0.98004535
155ERG_20517297_ChIP-Seq_VCAP_Human0.97279229
156PHF8_20622853_ChIP-Seq_HELA_Human0.97160766
157SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96852903
158ESET_19884257_ChIP-Seq_ESCs_Mouse0.95922937
159TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95595677
160NANOG_20526341_ChIP-Seq_ESCs_Human0.94965066
161ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94046456
162PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92602325
163ZFX_18555785_Chip-Seq_ESCs_Mouse0.92183300
164TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.91998333
165SOX2_18555785_Chip-Seq_ESCs_Mouse0.91912013
166GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91738747
167* LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91430949
168NMYC_18555785_Chip-Seq_ESCs_Mouse0.91007549
169PU1_27457419_Chip-Seq_LIVER_Mouse0.90274583
170GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90271166
171YY1_22570637_ChIP-Seq_MALME-3M_Human0.86849333
172SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86777825
173E2F1_18555785_Chip-Seq_ESCs_Mouse0.86459259
174PHF8_20622854_ChIP-Seq_HELA_Human0.84890478
175PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84781080
176FLI1_21867929_ChIP-Seq_CD8_Mouse0.83976141
177LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83338666
178EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83136120
179* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82978204

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.73070240
2* MP0001929_abnormal_gametogenesis5.29875411
3MP0008877_abnormal_DNA_methylation5.23575864
4MP0002210_abnormal_sex_determination3.69561024
5MP0002653_abnormal_ependyma_morphology3.33031427
6MP0001661_extended_life_span3.32300172
7MP0005377_hearing/vestibular/ear_phenot3.15921541
8MP0003878_abnormal_ear_physiology3.15921541
9MP0005360_urolithiasis3.12816827
10MP0002736_abnormal_nociception_after3.12622527
11MP0002161_abnormal_fertility/fecundity3.08497971
12* MP0001145_abnormal_male_reproductive3.05881535
13MP0000013_abnormal_adipose_tissue2.81423202
14* MP0000653_abnormal_sex_gland2.63497053
15MP0005623_abnormal_meninges_morphology2.58052746
16MP0002139_abnormal_hepatobiliary_system2.56861392
17MP0001968_abnormal_touch/_nociception2.42322599
18MP0002938_white_spotting2.40868519
19MP0008057_abnormal_DNA_replication2.30641874
20MP0005646_abnormal_pituitary_gland2.15577060
21MP0005085_abnormal_gallbladder_physiolo2.05421358
22MP0004885_abnormal_endolymph2.02766006
23MP0008058_abnormal_DNA_repair2.02629366
24MP0005410_abnormal_fertilization14.7674845
25MP0004133_heterotaxia1.91690175
26MP0009046_muscle_twitch1.85692042
27MP0005551_abnormal_eye_electrophysiolog1.81690441
28MP0002735_abnormal_chemical_nociception1.66486786
29MP0002160_abnormal_reproductive_system1.66365583
30MP0010094_abnormal_chromosome_stability1.62907412
31MP0005670_abnormal_white_adipose1.51339131
32MP0005332_abnormal_amino_acid1.48597859
33MP0003646_muscle_fatigue1.43939727
34MP0004147_increased_porphyrin_level1.43698379
35MP0000678_abnormal_parathyroid_gland1.39374343
36MP0002272_abnormal_nervous_system1.35809375
37MP0001486_abnormal_startle_reflex1.33707843
38MP0001485_abnormal_pinna_reflex1.33456904
39MP0009053_abnormal_anal_canal1.32715375
40MP0002282_abnormal_trachea_morphology1.29145090
41MP0000516_abnormal_urinary_system1.26032273
42MP0005367_renal/urinary_system_phenotyp1.26032273
43MP0001666_abnormal_nutrient_absorption1.22248902
44MP0008007_abnormal_cellular_replicative1.21856176
45MP0000026_abnormal_inner_ear1.21100075
46MP0002638_abnormal_pupillary_reflex1.20071828
47MP0003121_genomic_imprinting1.19555622
48MP0005397_hematopoietic_system_phenotyp1.16232411
49MP0001545_abnormal_hematopoietic_system1.16232411
50MP0004808_abnormal_hematopoietic_stem1.03326776
51MP0001963_abnormal_hearing_physiology1.01984283
52MP0000534_abnormal_ureter_morphology1.01327627
53MP0001502_abnormal_circadian_rhythm1.00565889
54MP0009745_abnormal_behavioral_response1.00416353
55MP0003868_abnormal_feces_composition0.99702351
56MP0004233_abnormal_muscle_weight0.99097766
57MP0002108_abnormal_muscle_morphology0.98284159
58MP0003879_abnormal_hair_cell0.97705822
59MP0001984_abnormal_olfaction0.97347354
60MP0001765_abnormal_ion_homeostasis0.96540117
61MP0004142_abnormal_muscle_tone0.95500038
62MP0003119_abnormal_digestive_system0.94126135
63MP0003635_abnormal_synaptic_transmissio0.93940639
64MP0003122_maternal_imprinting0.92488361
65MP0003786_premature_aging0.90607880
66MP0005389_reproductive_system_phenotype0.90539264
67MP0003763_abnormal_thymus_physiology0.89627816
68MP0005647_abnormal_sex_gland0.89592929
69MP0000003_abnormal_adipose_tissue0.87362137
70MP0001905_abnormal_dopamine_level0.87228248
71MP0002734_abnormal_mechanical_nocicepti0.86870133
72MP0002572_abnormal_emotion/affect_behav0.85832030
73MP0003942_abnormal_urinary_system0.85526379
74MP0004742_abnormal_vestibular_system0.84296394
75MP0000955_abnormal_spinal_cord0.83826221
76MP0005220_abnormal_exocrine_pancreas0.83416272
77MP0006276_abnormal_autonomic_nervous0.82509343
78MP0002229_neurodegeneration0.78036725
79MP0000631_abnormal_neuroendocrine_gland0.77805213
80MP0001293_anophthalmia0.77617672
81MP0002132_abnormal_respiratory_system0.75943281
82MP0005174_abnormal_tail_pigmentation0.75619961
83MP0002138_abnormal_hepatobiliary_system0.75428872
84MP0008995_early_reproductive_senescence0.75336058
85MP0002557_abnormal_social/conspecific_i0.74819400
86MP0002064_seizures0.73570686
87MP0002928_abnormal_bile_duct0.73033303
88MP0002184_abnormal_innervation0.72741514
89MP0005310_abnormal_salivary_gland0.72533900
90MP0001835_abnormal_antigen_presentation0.72417406
91MP0000230_abnormal_systemic_arterial0.71488459
92MP0002249_abnormal_larynx_morphology0.71301001
93MP0002405_respiratory_system_inflammati0.70679897
94MP0003936_abnormal_reproductive_system0.70628409
95MP0004859_abnormal_synaptic_plasticity0.69991624
96MP0003880_abnormal_central_pattern0.69725099
97MP0002067_abnormal_sensory_capabilities0.68791544
98MP0000371_diluted_coat_color0.68055687
99MP0002063_abnormal_learning/memory/cond0.67358749
100MP0005595_abnormal_vascular_smooth0.67053439
101MP0010307_abnormal_tumor_latency0.66630926
102MP0005195_abnormal_posterior_eye0.66369586
103MP0003718_maternal_effect0.63730643
104MP0000313_abnormal_cell_death0.62851440
105MP0003252_abnormal_bile_duct0.62496972
106MP0000358_abnormal_cell_content/0.61665337
107MP0001727_abnormal_embryo_implantation0.61369862
108MP0000470_abnormal_stomach_morphology0.60996373
109MP0003111_abnormal_nucleus_morphology0.60762537
110MP0002398_abnormal_bone_marrow0.60184212
111MP0004264_abnormal_extraembryonic_tissu0.59468045
112MP0002752_abnormal_somatic_nervous0.58653923
113MP0003656_abnormal_erythrocyte_physiolo0.57835449
114MP0006036_abnormal_mitochondrial_physio0.57555428
115MP0003699_abnormal_female_reproductive0.57088824
116MP0000685_abnormal_immune_system0.56397376
117MP0003943_abnormal_hepatobiliary_system0.53169053
118MP0005464_abnormal_platelet_physiology0.52959419
119MP0000703_abnormal_thymus_morphology0.52129778
120MP0003183_abnormal_peptide_metabolism0.50595466
121MP0003011_delayed_dark_adaptation0.50192703
122MP0003077_abnormal_cell_cycle0.49756916
123MP0000569_abnormal_digit_pigmentation0.49215157
124MP0009278_abnormal_bone_marrow0.49202990
125MP0005636_abnormal_mineral_homeostasis0.49069587
126MP0001730_embryonic_growth_arrest0.48753272
127MP0001119_abnormal_female_reproductive0.48548730
128MP0002396_abnormal_hematopoietic_system0.48147276
129MP0000015_abnormal_ear_pigmentation0.46588396
130MP0004036_abnormal_muscle_relaxation0.46159308
131MP0005671_abnormal_response_to0.45477861
132MP0002723_abnormal_immune_serum0.45104357
133MP0001986_abnormal_taste_sensitivity0.44410781
134MP0000716_abnormal_immune_system0.43969934
135MP0001324_abnormal_eye_pigmentation0.43165202
136MP0003866_abnormal_defecation0.42637027
137MP0000689_abnormal_spleen_morphology0.41811889
138MP0003950_abnormal_plasma_membrane0.40331416
139MP0002420_abnormal_adaptive_immunity0.39763029
140MP0002429_abnormal_blood_cell0.39213672
141MP0000427_abnormal_hair_cycle0.38490410
142MP0003633_abnormal_nervous_system0.38456801
143MP0005025_abnormal_response_to0.38379845
144MP0001819_abnormal_immune_cell0.37539565
145MP0009785_altered_susceptibility_to0.36314241
146MP0001800_abnormal_humoral_immune0.36272441
147MP0002722_abnormal_immune_system0.35575346
148MP0005075_abnormal_melanosome_morpholog0.35170419
149MP0003787_abnormal_imprinting0.35027699
150MP0004134_abnormal_chest_morphology0.34271865
151MP0002019_abnormal_tumor_incidence0.33969834
152MP0005000_abnormal_immune_tolerance0.32618773
153MP0005391_vision/eye_phenotype0.31877522
154MP0002234_abnormal_pharynx_morphology0.29590487
155MP0002452_abnormal_antigen_presenting0.29468540
156MP0005253_abnormal_eye_physiology0.27029473
157MP0004084_abnormal_cardiac_muscle0.25172931
158MP0002092_abnormal_eye_morphology0.25125891
159MP0004811_abnormal_neuron_physiology0.24484955
160MP0006054_spinal_hemorrhage0.23827087
161MP0001764_abnormal_homeostasis0.23752527
162MP0002095_abnormal_skin_pigmentation0.22897528
163MP0001348_abnormal_lacrimal_gland0.22725423
164MP0001845_abnormal_inflammatory_respons0.21436577
165MP0003115_abnormal_respiratory_system0.21122057
166MP0008872_abnormal_physiological_respon0.20164479
167MP0005423_abnormal_somatic_nervous0.20127957
168MP0003631_nervous_system_phenotype0.19449333
169MP0002080_prenatal_lethality0.18427096
170MP0008875_abnormal_xenobiotic_pharmacok0.18317533
171MP0001697_abnormal_embryo_size0.17485288

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.28669409
2Rhinitis (HP:0012384)7.88657198
3Abnormal respiratory motile cilium morphology (HP:0005938)7.73981022
4Abnormal respiratory epithelium morphology (HP:0012253)7.73981022
5Abnormal ciliary motility (HP:0012262)7.63772944
6Nasal polyposis (HP:0100582)7.04285146
7Chronic bronchitis (HP:0004469)6.97555482
8Abnormality of the nasal mucosa (HP:0000433)5.84792756
9Infertility (HP:0000789)5.83627123
10Congenital sensorineural hearing impairment (HP:0008527)5.15303180
11Bronchitis (HP:0012387)5.09024651
12Bronchiectasis (HP:0002110)4.86442655
13Nephronophthisis (HP:0000090)4.51709291
14Abnormal spermatogenesis (HP:0008669)4.03898596
15Attenuation of retinal blood vessels (HP:0007843)3.96709563
16Chorioretinal atrophy (HP:0000533)3.88398310
17Recurrent bronchitis (HP:0002837)3.83337431
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.83059476
19Abnormality of alanine metabolism (HP:0010916)3.83059476
20Hyperalaninemia (HP:0003348)3.83059476
21Recurrent sinusitis (HP:0011108)3.82665754
22Male infertility (HP:0003251)3.76509701
23Recurrent otitis media (HP:0000403)3.56451181
24Constricted visual fields (HP:0001133)3.46459383
25Menstrual irregularities (HP:0000858)3.41653876
26Esophageal varix (HP:0002040)3.40167556
27Abnormality of the renal medulla (HP:0100957)3.39700938
28Resting tremor (HP:0002322)3.37378763
29Cone-rod dystrophy (HP:0000548)3.22362625
30Abnormality of midbrain morphology (HP:0002418)3.11210481
31Molar tooth sign on MRI (HP:0002419)3.11210481
32Azoospermia (HP:0000027)3.02932730
33White forelock (HP:0002211)3.00410301
34Cortical visual impairment (HP:0100704)2.99501319
35Abolished electroretinogram (ERG) (HP:0000550)2.96376104
36Abnormality of the lower motor neuron (HP:0002366)2.96241480
37Focal segmental glomerulosclerosis (HP:0000097)2.91570607
38Medial flaring of the eyebrow (HP:0010747)2.80496356
39Patchy hypopigmentation of hair (HP:0011365)2.77519037
40Generalized aminoaciduria (HP:0002909)2.76826317
41Decreased electroretinogram (ERG) amplitude (HP:0000654)2.76267546
42Portal hypertension (HP:0001409)2.75497214
43Anterior segment dysgenesis (HP:0007700)2.75468484
44Tubular atrophy (HP:0000092)2.75055125
45Tubulointerstitial abnormality (HP:0001969)2.63769364
46Abnormality of dental color (HP:0011073)2.63127577
47Metaphyseal dysplasia (HP:0100255)2.61327257
48Type II lissencephaly (HP:0007260)2.61093796
49Tubulointerstitial nephritis (HP:0001970)2.60671096
50Hypoalphalipoproteinemia (HP:0003233)2.58122034
51Absent frontal sinuses (HP:0002688)2.56744723
52Action tremor (HP:0002345)2.53789559
53Abnormality of the hepatic vasculature (HP:0006707)2.50333902
54Periauricular skin pits (HP:0100277)2.47484748
55Preauricular pit (HP:0004467)2.47484748
56Tongue fasciculations (HP:0001308)2.42569810
57Conjunctival telangiectasia (HP:0000524)2.41885210
58Tubulointerstitial fibrosis (HP:0005576)2.41334608
59Fibular hypoplasia (HP:0003038)2.41252690
60Hypercholesterolemia (HP:0003124)2.41190068
61Gonadotropin excess (HP:0000837)2.39672611
62Bony spicule pigmentary retinopathy (HP:0007737)2.39143453
63Amyotrophic lateral sclerosis (HP:0007354)2.37916941
64Insulin-resistant diabetes mellitus (HP:0000831)2.37650875
65Abnormality of macular pigmentation (HP:0008002)2.34305090
66Aplasia/Hypoplasia of the tibia (HP:0005772)2.33656086
67Glomerulosclerosis (HP:0000096)2.32454995
68Progressive cerebellar ataxia (HP:0002073)2.32159708
69Postaxial foot polydactyly (HP:0001830)2.29959528
70Severe visual impairment (HP:0001141)2.29228659
71Abnormality of sulfur amino acid metabolism (HP:0004339)2.28944804
72Microglossia (HP:0000171)2.28376283
73Spontaneous hematomas (HP:0007420)2.28298320
74J-shaped sella turcica (HP:0002680)2.28110418
75Congenital hepatic fibrosis (HP:0002612)2.23847760
76Osteomalacia (HP:0002749)2.22241644
77Polydipsia (HP:0001959)2.21935852
78Abnormal drinking behavior (HP:0030082)2.21935852
79Abnormality of the aortic arch (HP:0012303)2.21520800
80Pancreatic fibrosis (HP:0100732)2.21134289
81Retinal dysplasia (HP:0007973)2.20124666
82Unilateral renal agenesis (HP:0000122)2.19082995
83Short tibia (HP:0005736)2.18832317
84Chronic sinusitis (HP:0011109)2.18469501
85Muscle fibrillation (HP:0010546)2.12506103
86Hyperkalemia (HP:0002153)2.11332552
87Postural instability (HP:0002172)2.10338956
88Febrile seizures (HP:0002373)2.09665397
89Median cleft lip (HP:0000161)2.08716168
90Ileus (HP:0002595)2.07828157
91Facial cleft (HP:0002006)2.04901095
92Cheilitis (HP:0100825)2.04247667
93Skin pits (HP:0100276)2.03596252
94Prominent supraorbital ridges (HP:0000336)2.02326645
95Male pseudohermaphroditism (HP:0000037)2.00801265
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.0128826
97Dynein arm defect of respiratory motile cilia (HP:0012255)11.1424654
98Absent/shortened dynein arms (HP:0200106)11.1424654
99Homocystinuria (HP:0002156)1.98583830
100Abnormality of homocysteine metabolism (HP:0010919)1.98583830
101Short ribs (HP:0000773)1.97936395
102Abnormality of saccadic eye movements (HP:0000570)1.97934900
103Renal dysplasia (HP:0000110)1.97727364
104Abnormality of the renal cortex (HP:0011035)1.97201915
10511 pairs of ribs (HP:0000878)1.96839149
106Impulsivity (HP:0100710)1.93310708
107Gaze-evoked nystagmus (HP:0000640)1.91450894
108Increased purine levels (HP:0004368)1.91369951
109Hyperuricemia (HP:0002149)1.91369951
110Deformed sella turcica (HP:0002681)1.91011713
111Abnormality of lateral ventricle (HP:0030047)1.90347888
112Genital tract atresia (HP:0001827)1.90129313
113Type II diabetes mellitus (HP:0005978)1.89888289
114Impaired proprioception (HP:0010831)1.88572326
115Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.88119356
116Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83904415
117Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.83604205
118Abnormality of the renal collecting system (HP:0004742)1.83389942
119Oculomotor apraxia (HP:0000657)1.82938119
120Dyskinesia (HP:0100660)1.81914140
121Aplasia/Hypoplasia of the tongue (HP:0010295)1.80718366
122Abnormality of the vasculature of the conjunctiva (HP:0008054)1.80396533
123Bile duct proliferation (HP:0001408)1.78701058
124Abnormal biliary tract physiology (HP:0012439)1.78701058
125Abnormality of ocular smooth pursuit (HP:0000617)1.77113781
126Recurrent corneal erosions (HP:0000495)1.76415025
127Abnormality of cochlea (HP:0000375)1.76088889
128Stage 5 chronic kidney disease (HP:0003774)1.76048521
129Depressed nasal tip (HP:0000437)1.75298340
130Hypoplastic left heart (HP:0004383)1.73647622
131Upper motor neuron abnormality (HP:0002127)1.73235910
132Photophobia (HP:0000613)1.72252579
133Absent eyebrow (HP:0002223)1.69428194
134Abnormality of the anterior horn cell (HP:0006802)1.69293928
135Degeneration of anterior horn cells (HP:0002398)1.69293928
136Hypoplasia of the pons (HP:0012110)1.68586246
137Cupped ear (HP:0000378)1.68266414
138Hip dysplasia (HP:0001385)1.67862894
139Postaxial hand polydactyly (HP:0001162)1.67007706
140Renal cortical cysts (HP:0000803)1.66913373
141Heterochromia iridis (HP:0001100)1.66179084
142Atonic seizures (HP:0010819)1.66155555
143Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65156423
144Decreased central vision (HP:0007663)1.65112848
145Abnormality of renal excretion (HP:0011036)1.64533604
146Cystic liver disease (HP:0006706)1.56299781
147Spontaneous abortion (HP:0005268)1.52268156
148Short thorax (HP:0010306)1.50984551
149Dyschromatopsia (HP:0007641)1.47234451
150Cerebellar dysplasia (HP:0007033)1.45964761
151Nephropathy (HP:0000112)1.44519853
152Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.43654854
153Limb ataxia (HP:0002070)1.43202564
154Abnormal urine output (HP:0012590)1.41316777
155Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.41286987
156Absent epiphyses (HP:0010577)1.41286987
157Abnormality of the frontal sinuses (HP:0002687)1.40506903
158Abnormality of permanent molar morphology (HP:0011071)1.38758659
159Abnormality of the dental root (HP:0006486)1.38758659
160Taurodontia (HP:0000679)1.38758659
161Aplasia/Hypoplasia of the fibula (HP:0006492)1.37718344
162Heterotopia (HP:0002282)1.37224163
163Polyuria (HP:0000103)1.37131794
164Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.36103956
165Large eyes (HP:0001090)1.35083801
166Congenital primary aphakia (HP:0007707)1.34212901
167True hermaphroditism (HP:0010459)1.33508352
168Gait imbalance (HP:0002141)1.33211886
169Chronic hepatic failure (HP:0100626)1.32130873
170Nephroblastoma (Wilms tumor) (HP:0002667)1.32115807
171Abnormality of molar morphology (HP:0011070)1.30465036
172Abnormality of molar (HP:0011077)1.30465036
173Impaired smooth pursuit (HP:0007772)1.30389194
174Occipital encephalocele (HP:0002085)1.29589766
175Pachygyria (HP:0001302)1.29489629
176Easy fatigability (HP:0003388)1.28499925

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.54443291
2PDK38.54443291
3PDK25.32851059
4TESK14.99089387
5TAF14.63347990
6PRKD33.67971157
7BMPR1B3.41514202
8FRK3.39384152
9PTK2B3.09173375
10ICK2.85211209
11WNK42.63967477
12NTRK12.62261561
13STK392.43129734
14MAP4K22.40593791
15EIF2AK32.31314923
16TAOK32.30167835
17INSRR2.13922050
18NTRK32.01676477
19NEK21.92806447
20MAP3K31.68910984
21WEE11.63513979
22STK381.59442185
23CDK91.53352343
24PLK21.51955694
25PNCK1.43364674
26KSR21.36416380
27PIK3CG1.35296458
28MAP3K21.28346230
29BRSK21.27264448
30CCNB11.17476364
31PDK11.17240164
32EEF2K1.15810750
33MAP2K71.10456143
34FGR1.08456422
35SGK4941.05985387
36SGK2231.05985387
37CDC71.05626159
38PASK1.05335801
39TGFBR11.05248888
40DYRK31.02744676
41JAK31.01568717
42MAP2K30.98366234
43STK240.95908430
44ZAP700.95205248
45WNK10.86407560
46MAP2K10.85183341
47STK110.84505304
48DYRK1B0.83973563
49ATR0.82491748
50SGK20.82442320
51ADRBK10.80981061
52OXSR10.80910710
53MAPK150.78817221
54MAP4K10.77704622
55TYRO30.77678721
56MAP3K60.76642371
57BRD40.70057063
58ZAK0.68696302
59FGFR20.68121630
60TTK0.68094165
61JAK20.68051889
62TIE10.67470376
63DDR20.63486523
64CHEK20.62499433
65LMTK20.61925122
66PRKCE0.59887382
67CHEK10.58724405
68STK30.58004692
69PKN10.55470490
70RIPK40.54547562
71PRKD10.52538181
72MAPK130.51602399
73BRSK10.50135610
74SGK10.49745251
75PDPK10.49448015
76MAP2K20.48633870
77CSNK1A10.47146077
78SIK20.46592133
79STK38L0.45826377
80MAP2K60.45350011
81CSF1R0.45056026
82MAPK120.44922168
83ACVR1B0.43651074
84ATM0.43498866
85CAMK10.42455266
86NLK0.42242033
87MARK10.42061761
88NUAK10.41581280
89MAP3K40.41555199
90MAP2K40.41527353
91EPHB20.40504976
92RPS6KB10.40073957
93MAPKAPK50.39391432
94CDK30.38458291
95CDK50.38389638
96PLK10.38254396
97STK100.37963781
98GRK10.37944116
99IRAK10.35755907
100RPS6KA50.35695128
101DYRK1A0.35118125
102TLK10.34961682
103AKT10.33998597
104FES0.33956931
105RET0.33880082
106SCYL20.33604029
107CAMK2A0.33303488
108RPS6KB20.33199920
109KIT0.32702804
110STK160.30986630
111PRKACA0.30068001
112MAPK10.29984527
113TXK0.29537921
114PINK10.29326380
115CAMK2D0.28253617
116BTK0.28015024
117SIK10.27501560
118EGFR0.27260350
119SYK0.27111584
120LATS10.25438913
121AKT20.25300404
122CDK70.24932126
123PLK40.24373425
124PAK10.23916747
125TESK20.21582471
126TEC0.20001917
127TBK10.19914951
128MARK30.19640440
129PRKG20.19287161
130PAK20.16698641
131PDGFRB0.16256340
132PRKCQ0.15891281
133CSNK2A20.15722916
134MARK20.14537669
135PRKCG0.14121085
136CSNK2A10.13286314
137MUSK0.12789042
138NEK60.11015511
139CAMKK10.11000491
140MTOR0.10800485
141PIM10.10699384
142CDK20.09452004
143PRKDC0.07582096
144CAMK1G0.07009219
145CDK10.06998130
146LCK0.06799895
147PRKAA10.06764536
148RPS6KA40.06714274
149MAPK80.04908554
150CLK10.04335832
151PRKCD0.04127480
152TAOK10.03209778
153IRAK20.02800146
154GSK3B0.02602350
155NTRK20.02263324
156MAP3K100.01792570
157VRK10.01757694
158CSK0.01596378
159MAP3K50.01446942
160MATK0.01320302
161ITK0.01078733
162LYN0.00721176
163RPS6KA10.00442697
164MAPKAPK30.00120609
165ADRBK2-0.0048327
166PRKCZ-0.0040750
167PRKG1-0.0028760

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose phosphate pathway_Homo sapiens_hsa000304.09326579
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.80437267
3Pyruvate metabolism_Homo sapiens_hsa006203.62733662
4Vitamin B6 metabolism_Homo sapiens_hsa007503.50182087
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.43707122
6Olfactory transduction_Homo sapiens_hsa047403.37074098
7Basal transcription factors_Homo sapiens_hsa030223.27050693
8Fatty acid biosynthesis_Homo sapiens_hsa000612.93271635
9Fanconi anemia pathway_Homo sapiens_hsa034602.84285284
10Propanoate metabolism_Homo sapiens_hsa006402.74439844
11Glucagon signaling pathway_Homo sapiens_hsa049222.61775362
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.58760831
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.48921723
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.42980345
15Nicotine addiction_Homo sapiens_hsa050332.40464916
16Arginine biosynthesis_Homo sapiens_hsa002202.33545122
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.30267282
18Linoleic acid metabolism_Homo sapiens_hsa005912.21790526
19Maturity onset diabetes of the young_Homo sapiens_hsa049502.21319520
20Morphine addiction_Homo sapiens_hsa050322.07135695
21Renin-angiotensin system_Homo sapiens_hsa046142.05752783
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.93243014
23GABAergic synapse_Homo sapiens_hsa047271.89187683
24Glutamatergic synapse_Homo sapiens_hsa047241.86375245
25Oocyte meiosis_Homo sapiens_hsa041141.84256585
26Selenocompound metabolism_Homo sapiens_hsa004501.84250902
27Huntingtons disease_Homo sapiens_hsa050161.76656674
28Butanoate metabolism_Homo sapiens_hsa006501.74382613
29Homologous recombination_Homo sapiens_hsa034401.71801784
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.70440770
31Antigen processing and presentation_Homo sapiens_hsa046121.68327778
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.64763626
33Glycerolipid metabolism_Homo sapiens_hsa005611.58933473
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.58590091
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.55133446
36Serotonergic synapse_Homo sapiens_hsa047261.54464876
37Circadian entrainment_Homo sapiens_hsa047131.50113969
38Carbon metabolism_Homo sapiens_hsa012001.49438267
39Dorso-ventral axis formation_Homo sapiens_hsa043201.48552874
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.47502625
41RNA transport_Homo sapiens_hsa030131.47294051
42mRNA surveillance pathway_Homo sapiens_hsa030151.46206002
43Nitrogen metabolism_Homo sapiens_hsa009101.44925953
44Type II diabetes mellitus_Homo sapiens_hsa049301.34737907
45One carbon pool by folate_Homo sapiens_hsa006701.31931993
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.31219750
47Amphetamine addiction_Homo sapiens_hsa050311.30997149
48Collecting duct acid secretion_Homo sapiens_hsa049661.28648144
49DNA replication_Homo sapiens_hsa030301.27817036
50Phototransduction_Homo sapiens_hsa047441.26935612
51Biosynthesis of amino acids_Homo sapiens_hsa012301.24204172
52Glycerophospholipid metabolism_Homo sapiens_hsa005641.22057678
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.18806684
54Retinol metabolism_Homo sapiens_hsa008301.15753911
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15680095
56Purine metabolism_Homo sapiens_hsa002301.15028508
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14597385
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12014166
59Regulation of autophagy_Homo sapiens_hsa041401.11246672
60Lysine degradation_Homo sapiens_hsa003101.07901599
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06324327
62Renin secretion_Homo sapiens_hsa049241.02300041
63PPAR signaling pathway_Homo sapiens_hsa033201.02062955
64Base excision repair_Homo sapiens_hsa034101.00284079
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99539417
66TGF-beta signaling pathway_Homo sapiens_hsa043500.99304603
67Fructose and mannose metabolism_Homo sapiens_hsa000510.96642601
68Systemic lupus erythematosus_Homo sapiens_hsa053220.94439976
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93259030
70Tryptophan metabolism_Homo sapiens_hsa003800.91943036
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90609661
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90457401
73B cell receptor signaling pathway_Homo sapiens_hsa046620.90060836
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89512946
75Bile secretion_Homo sapiens_hsa049760.88063496
76Dopaminergic synapse_Homo sapiens_hsa047280.87475493
77N-Glycan biosynthesis_Homo sapiens_hsa005100.87225034
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84753355
79RNA degradation_Homo sapiens_hsa030180.83869889
80Legionellosis_Homo sapiens_hsa051340.83327363
81Fat digestion and absorption_Homo sapiens_hsa049750.83325999
82Primary immunodeficiency_Homo sapiens_hsa053400.83241584
83Cardiac muscle contraction_Homo sapiens_hsa042600.81953930
84Long-term depression_Homo sapiens_hsa047300.81488627
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.81326721
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77721113
87Cholinergic synapse_Homo sapiens_hsa047250.76819723
88Ether lipid metabolism_Homo sapiens_hsa005650.76182113
89Non-homologous end-joining_Homo sapiens_hsa034500.76042479
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75524327
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73677719
92Cell cycle_Homo sapiens_hsa041100.73315836
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72261670
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71701627
95Synaptic vesicle cycle_Homo sapiens_hsa047210.70602232
96Spliceosome_Homo sapiens_hsa030400.70082670
97Salivary secretion_Homo sapiens_hsa049700.69805161
98Gap junction_Homo sapiens_hsa045400.68089054
99Viral carcinogenesis_Homo sapiens_hsa052030.67835723
100Long-term potentiation_Homo sapiens_hsa047200.67748486
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.67405920
102Histidine metabolism_Homo sapiens_hsa003400.67288019
103Pyrimidine metabolism_Homo sapiens_hsa002400.67282907
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67171746
105Fatty acid degradation_Homo sapiens_hsa000710.64757163
106ABC transporters_Homo sapiens_hsa020100.62049507
107Ras signaling pathway_Homo sapiens_hsa040140.61849528
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61827042
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.61714923
110Caffeine metabolism_Homo sapiens_hsa002320.60448106
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60393381
112beta-Alanine metabolism_Homo sapiens_hsa004100.58280119
113Herpes simplex infection_Homo sapiens_hsa051680.57955544
114T cell receptor signaling pathway_Homo sapiens_hsa046600.54848004
115Sphingolipid metabolism_Homo sapiens_hsa006000.54550514
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54257899
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.53674734
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.53415530
119cAMP signaling pathway_Homo sapiens_hsa040240.53365814
120Fatty acid metabolism_Homo sapiens_hsa012120.53142394
121Estrogen signaling pathway_Homo sapiens_hsa049150.52761548
122Endocytosis_Homo sapiens_hsa041440.50961608
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50950877
124Arachidonic acid metabolism_Homo sapiens_hsa005900.50790161
125Glutathione metabolism_Homo sapiens_hsa004800.49538269
126Protein digestion and absorption_Homo sapiens_hsa049740.48247517
127Arginine and proline metabolism_Homo sapiens_hsa003300.47752488
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46567923
129Calcium signaling pathway_Homo sapiens_hsa040200.46054874
130Cocaine addiction_Homo sapiens_hsa050300.45535239
131Vitamin digestion and absorption_Homo sapiens_hsa049770.45492781
132Mineral absorption_Homo sapiens_hsa049780.44908136
133Measles_Homo sapiens_hsa051620.44707380
134Taste transduction_Homo sapiens_hsa047420.44645147
135Salmonella infection_Homo sapiens_hsa051320.42920378
136Prion diseases_Homo sapiens_hsa050200.42882200
137Epstein-Barr virus infection_Homo sapiens_hsa051690.42772896
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42515317
139AMPK signaling pathway_Homo sapiens_hsa041520.41665971
140Axon guidance_Homo sapiens_hsa043600.40260705
141Thyroid hormone synthesis_Homo sapiens_hsa049180.38857811
142Pancreatic secretion_Homo sapiens_hsa049720.38479310
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38198150
144cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37820767
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37610021
146ECM-receptor interaction_Homo sapiens_hsa045120.36613244
147Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35558723
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34688356
149Mismatch repair_Homo sapiens_hsa034300.34676714
150Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34604208
151Insulin secretion_Homo sapiens_hsa049110.34479123
152Alcoholism_Homo sapiens_hsa050340.34128413
153Hedgehog signaling pathway_Homo sapiens_hsa043400.32346433
154Sulfur relay system_Homo sapiens_hsa041220.31567919
155Choline metabolism in cancer_Homo sapiens_hsa052310.30015383
156Oxytocin signaling pathway_Homo sapiens_hsa049210.29879311
157Phenylalanine metabolism_Homo sapiens_hsa003600.28827627
158Nucleotide excision repair_Homo sapiens_hsa034200.28402691
159VEGF signaling pathway_Homo sapiens_hsa043700.28252998
160Shigellosis_Homo sapiens_hsa051310.26633880
161Influenza A_Homo sapiens_hsa051640.26441742
162Circadian rhythm_Homo sapiens_hsa047100.26254779
163HTLV-I infection_Homo sapiens_hsa051660.26107670
164Metabolic pathways_Homo sapiens_hsa011000.26022335
165Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24107245
166Inositol phosphate metabolism_Homo sapiens_hsa005620.24046993
167Toxoplasmosis_Homo sapiens_hsa051450.23764299
168Chemical carcinogenesis_Homo sapiens_hsa052040.21004265

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