ZPBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.89994891
2* acrosome assembly (GO:0001675)9.83598188
3* binding of sperm to zona pellucida (GO:0007339)9.76032882
4* cell-cell recognition (GO:0009988)9.66331404
5motile cilium assembly (GO:0044458)9.34111695
6spermatid development (GO:0007286)9.28314910
7reproduction (GO:0000003)9.06663987
8male meiosis (GO:0007140)8.87530371
9cilium movement (GO:0003341)8.54150798
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.44347211
11synaptonemal complex organization (GO:0070193)8.25569181
12regulation of cilium movement (GO:0003352)8.23952358
13synaptonemal complex assembly (GO:0007130)8.00964064
14single fertilization (GO:0007338)7.42588837
15sperm capacitation (GO:0048240)6.96846391
16DNA methylation involved in gamete generation (GO:0043046)6.44916021
17fertilization (GO:0009566)6.43446164
18negative regulation of inclusion body assembly (GO:0090084)6.25842909
19spermatogenesis (GO:0007283)6.09557113
20male gamete generation (GO:0048232)6.07480648
21male meiosis I (GO:0007141)5.99789623
22chromosome organization involved in meiosis (GO:0070192)5.62651587
23gamete generation (GO:0007276)5.58584368
24ventricular system development (GO:0021591)5.37171129
25germ cell development (GO:0007281)5.37142836
26microtubule depolymerization (GO:0007019)5.37106375
27organic cation transport (GO:0015695)5.31424724
28meiotic nuclear division (GO:0007126)5.23117300
29* cellular process involved in reproduction in multicellular organism (GO:0022412)5.21951699
30seminiferous tubule development (GO:0072520)5.14102826
31regulation of inclusion body assembly (GO:0090083)5.10065395
32reciprocal meiotic recombination (GO:0007131)4.98492555
33reciprocal DNA recombination (GO:0035825)4.98492555
34meiosis I (GO:0007127)4.89996836
35meiotic chromosome segregation (GO:0045132)4.86042211
36regulation of microtubule-based movement (GO:0060632)4.80783752
37microtubule severing (GO:0051013)4.76378630
38calcium ion-dependent exocytosis (GO:0017156)4.66680849
39meiotic cell cycle (GO:0051321)4.60953044
40* cell recognition (GO:0008037)4.49096028
41multicellular organismal reproductive process (GO:0048609)4.38125121
42protein localization to cilium (GO:0061512)4.27615628
43monoubiquitinated protein deubiquitination (GO:0035520)4.18933114
44left/right pattern formation (GO:0060972)4.11321314
45genitalia morphogenesis (GO:0035112)4.09955417
46DNA double-strand break processing (GO:0000729)3.99251233
47spermatid nucleus differentiation (GO:0007289)3.90414484
48gene silencing by RNA (GO:0031047)3.90012810
49L-fucose catabolic process (GO:0042355)3.84150690
50fucose catabolic process (GO:0019317)3.84150690
51L-fucose metabolic process (GO:0042354)3.84150690
52protein polyglutamylation (GO:0018095)3.82632244
53resolution of meiotic recombination intermediates (GO:0000712)3.82097484
54photoreceptor cell maintenance (GO:0045494)3.77429237
55chaperone-mediated protein complex assembly (GO:0051131)3.76963990
56sister chromatid cohesion (GO:0007062)3.72035464
57DNA synthesis involved in DNA repair (GO:0000731)3.69712880
58glycerol ether metabolic process (GO:0006662)3.68472810
59nonmotile primary cilium assembly (GO:0035058)3.68216884
60chromosome condensation (GO:0030261)3.66956226
61intraciliary transport (GO:0042073)3.61634888
62detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.58147613
63DNA packaging (GO:0006323)3.56670949
64multicellular organismal development (GO:0007275)3.54281871
65negative regulation of organelle assembly (GO:1902116)3.42881228
66meiotic cell cycle process (GO:1903046)3.42402196
67axoneme assembly (GO:0035082)3.39947029
68ether metabolic process (GO:0018904)3.39463986
69auditory receptor cell stereocilium organization (GO:0060088)3.35441177
70neural tube formation (GO:0001841)3.34267711
71indolalkylamine metabolic process (GO:0006586)3.33923869
72synapsis (GO:0007129)3.33764530
73retinal cone cell development (GO:0046549)3.32363303
74alditol metabolic process (GO:0019400)3.32087611
75double-strand break repair via homologous recombination (GO:0000724)3.30568879
76recombinational repair (GO:0000725)3.27280028
77pyrimidine nucleobase catabolic process (GO:0006208)3.23752612
78microtubule-based movement (GO:0007018)3.22961414
79indole-containing compound catabolic process (GO:0042436)3.21519416
80indolalkylamine catabolic process (GO:0046218)3.21519416
81tryptophan catabolic process (GO:0006569)3.21519416
82regulation of spindle checkpoint (GO:0090231)3.19859997
83response to pheromone (GO:0019236)3.19812875
84carnitine transport (GO:0015879)3.18317921
85amino-acid betaine transport (GO:0015838)3.18317921
86regulation of centriole replication (GO:0046599)3.18150231
87lactate metabolic process (GO:0006089)3.14610312
88carnitine transmembrane transport (GO:1902603)3.14560704
89positive regulation of meiosis (GO:0045836)3.13426114
90tachykinin receptor signaling pathway (GO:0007217)3.10488662
91polyol catabolic process (GO:0046174)3.10246844
92inner ear receptor stereocilium organization (GO:0060122)3.10035480
93nucleoside diphosphate phosphorylation (GO:0006165)3.07937941
94regulation of meiosis I (GO:0060631)3.06728339
95detection of light stimulus involved in visual perception (GO:0050908)3.06309258
96detection of light stimulus involved in sensory perception (GO:0050962)3.06309258
97nuclear pore complex assembly (GO:0051292)3.05886942
98mitotic sister chromatid cohesion (GO:0007064)3.04106515
99cilium organization (GO:0044782)3.01190557
100female gamete generation (GO:0007292)2.99567515
101regulation of protein glycosylation (GO:0060049)2.94955926
102histone H2A acetylation (GO:0043968)2.94662064
103protein refolding (GO:0042026)2.94638582
104glycerol metabolic process (GO:0006071)2.92847656
105protein K11-linked deubiquitination (GO:0035871)2.91723080
106replication fork processing (GO:0031297)2.90761684
107positive regulation of meiotic cell cycle (GO:0051446)2.90648680
108negative regulation of DNA-dependent DNA replication (GO:2000104)2.88091975
109nucleobase catabolic process (GO:0046113)2.85582279
110cilium assembly (GO:0042384)2.85060088
111single strand break repair (GO:0000012)2.84186424
112behavioral response to ethanol (GO:0048149)2.83565311
113cilium morphogenesis (GO:0060271)2.83059863
114gene silencing (GO:0016458)2.82272362
115nucleus organization (GO:0006997)2.81464967
116GTP biosynthetic process (GO:0006183)2.79375285
117centriole replication (GO:0007099)2.78566876
118establishment of protein localization to Golgi (GO:0072600)2.78398230
119centriole assembly (GO:0098534)2.76757221
120glycolytic process (GO:0006096)2.75406692
121regulation of protein polyubiquitination (GO:1902914)2.72610474
122sequestering of actin monomers (GO:0042989)2.70030840
123L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.69138522
124regulation of DNA endoreduplication (GO:0032875)2.68623788
125behavioral response to nicotine (GO:0035095)2.68490282
126tryptophan metabolic process (GO:0006568)2.67230786
127microtubule polymerization or depolymerization (GO:0031109)2.66377687
128oxidative demethylation (GO:0070989)2.66281336
129regulation of nuclear cell cycle DNA replication (GO:0033262)2.65598209
130cellular ketone body metabolic process (GO:0046950)2.65538439
131peptidyl-glutamic acid modification (GO:0018200)2.64918656
132* cellular component assembly involved in morphogenesis (GO:0010927)2.64677840
133transmission of nerve impulse (GO:0019226)2.62932286
134peptidyl-lysine trimethylation (GO:0018023)2.62908204
135kynurenine metabolic process (GO:0070189)2.62109251
136DNA integration (GO:0015074)2.61641273
137signal peptide processing (GO:0006465)2.59789893
138RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.57327657
139regulation of sarcomere organization (GO:0060297)2.56586990
140somite rostral/caudal axis specification (GO:0032525)2.56100252
141interferon-gamma secretion (GO:0072643)2.52224500
142UTP biosynthetic process (GO:0006228)2.50026878
143photoreceptor cell development (GO:0042461)2.49827672
144mismatch repair (GO:0006298)2.48269157
145DNA catabolic process, exonucleolytic (GO:0000738)2.42984652
146adenosine metabolic process (GO:0046085)2.40811404
147rRNA catabolic process (GO:0016075)2.40286176
148reflex (GO:0060004)2.39539547
149DNA replication-dependent nucleosome organization (GO:0034723)2.38743518
150DNA replication-dependent nucleosome assembly (GO:0006335)2.38743518
151protein targeting to Golgi (GO:0000042)2.38543337
152retinal rod cell development (GO:0046548)2.38069207
153ketone body metabolic process (GO:1902224)2.37498389
154maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.37088072
155cilium or flagellum-dependent cell motility (GO:0001539)14.2403769
156fusion of sperm to egg plasma membrane (GO:0007342)13.3329389
157sperm motility (GO:0030317)12.5254762
158multicellular organism reproduction (GO:0032504)10.9846887
159* sperm-egg recognition (GO:0035036)10.8032904
160axonemal dynein complex assembly (GO:0070286)10.7433194
161acrosome reaction (GO:0007340)10.6024984
162piRNA metabolic process (GO:0034587)10.3283478
163cell wall macromolecule metabolic process (GO:0044036)10.1818950
164cell wall macromolecule catabolic process (GO:0016998)10.1818950
165plasma membrane fusion (GO:0045026)10.0914864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.95930824
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.77322674
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.61321939
4GBX2_23144817_ChIP-Seq_PC3_Human3.00253483
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.94075555
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.89640086
7IGF1R_20145208_ChIP-Seq_DFB_Human2.89139851
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.75649841
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.56132357
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.39965848
11FUS_26573619_Chip-Seq_HEK293_Human2.36664567
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.33975956
13* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.32310871
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.30234375
15EWS_26573619_Chip-Seq_HEK293_Human2.28374472
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.27886523
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.25092627
18TAF15_26573619_Chip-Seq_HEK293_Human2.24921439
19P300_19829295_ChIP-Seq_ESCs_Human2.22973471
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22075204
21ZNF274_21170338_ChIP-Seq_K562_Hela2.16699404
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.09900807
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08024532
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07411858
25ER_23166858_ChIP-Seq_MCF-7_Human2.07326960
26GATA1_26923725_Chip-Seq_HPCs_Mouse2.01371917
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.7229033
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98225306
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.94993205
30* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90425491
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82593364
32VDR_22108803_ChIP-Seq_LS180_Human1.81706298
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.79478841
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77056575
35STAT3_23295773_ChIP-Seq_U87_Human1.76617443
36BCAT_22108803_ChIP-Seq_LS180_Human1.75404744
37SMAD4_21799915_ChIP-Seq_A2780_Human1.74717357
38TCF4_23295773_ChIP-Seq_U87_Human1.65384644
39FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62017878
40ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.60479669
41TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.57963617
42STAT1_17558387_ChIP-Seq_HELA_Human1.57937954
43WDR5_24793694_ChIP-Seq_LNCAP_Human1.56956668
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56146419
45KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.53626133
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52772524
47RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.52499574
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52228907
49AR_25329375_ChIP-Seq_VCAP_Human1.51866470
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50892153
51* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49521395
52* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49521395
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49489795
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.49255309
55KAP1_22055183_ChIP-Seq_ESCs_Mouse1.48963248
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.48861976
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47554196
58GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.47071070
59SOX2_22085726_ChIP-Seq_NPCs_Mouse1.41416255
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.40551480
61SOX2_19829295_ChIP-Seq_ESCs_Human1.40130670
62NANOG_19829295_ChIP-Seq_ESCs_Human1.40130670
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.39842818
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39540516
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39361072
66GATA3_21867929_ChIP-Seq_CD8_Mouse1.38801592
67TCF4_22108803_ChIP-Seq_LS180_Human1.38123039
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.36886916
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36432538
70TP53_22573176_ChIP-Seq_HFKS_Human1.35128465
71CBP_20019798_ChIP-Seq_JUKART_Human1.33074008
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33074008
73RUNX2_22187159_ChIP-Seq_PCA_Human1.31944971
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31554663
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.31052211
76TAL1_26923725_Chip-Seq_HPCs_Mouse1.30904854
77CDX2_22108803_ChIP-Seq_LS180_Human1.28381160
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27690258
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.27678980
80MYC_18940864_ChIP-ChIP_HL60_Human1.24915790
81FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23878023
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23703833
83KDM2B_26808549_Chip-Seq_REH_Human1.23395004
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23301231
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.23185811
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22473484
87GATA3_21867929_ChIP-Seq_TH1_Mouse1.22074652
88ELK1_19687146_ChIP-ChIP_HELA_Human1.21343793
89EST1_17652178_ChIP-ChIP_JURKAT_Human1.21073878
90LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.20118011
91SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19739240
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19084605
93EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17413902
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17252080
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17187444
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.17187444
97SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.15332611
98NOTCH1_21737748_ChIP-Seq_TLL_Human1.14052339
99IRF1_19129219_ChIP-ChIP_H3396_Human1.13556343
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13418764
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13283197
102* P53_21459846_ChIP-Seq_SAOS-2_Human1.12667647
103SMAD_19615063_ChIP-ChIP_OVARY_Human1.12636774
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.09762644
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.09425455
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09291960
107AR_20517297_ChIP-Seq_VCAP_Human1.09171351
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08697334
109SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07376250
110AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07029742
111CRX_20693478_ChIP-Seq_RETINA_Mouse1.06848376
112TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06829749
113CBX2_27304074_Chip-Seq_ESCs_Mouse1.06572723
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06012803
115REST_21632747_ChIP-Seq_MESCs_Mouse1.04388227
116SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04115768
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03499073
118YY1_22570637_ChIP-Seq_MALME-3M_Human1.03199007
119CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02723501
120FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02685424
121SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02472671
122AR_21572438_ChIP-Seq_LNCaP_Human1.02333308
123GF1_26923725_Chip-Seq_HPCs_Mouse1.01977271
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01075101
125CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01013984
126ERG_20517297_ChIP-Seq_VCAP_Human1.00229963
127* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00041164
128RUNX1_26923725_Chip-Seq_HPCs_Mouse0.99279915
129OCT4_18555785_Chip-Seq_ESCs_Mouse0.98484034
130SPI1_26923725_Chip-Seq_HPCs_Mouse0.98447328
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98092057
132RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97817386
133PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97436341
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95250464
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94341083
136NANOG_18555785_Chip-Seq_ESCs_Mouse0.93757912
137* RARA_24833708_ChIP-Seq_LIVER_Mouse0.92722409
138ESET_19884257_ChIP-Seq_ESCs_Mouse0.92524168
139OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92507576
140EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91787015
141SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91673633
142PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91413295
143EZH2_27294783_Chip-Seq_NPCs_Mouse0.90962335
144* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90537265
145LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88980743
146P53_22387025_ChIP-Seq_ESCs_Mouse0.88472466
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88361085
148EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88330029
149ELF1_20517297_ChIP-Seq_JURKAT_Human0.88322150
150KLF4_18555785_Chip-Seq_ESCs_Mouse0.88202670
151MYC_27129775_Chip-Seq_CORNEA_Mouse0.87959837
152P300_18555785_Chip-Seq_ESCs_Mouse0.86771537
153* FLI1_21867929_ChIP-Seq_CD8_Mouse0.86436997
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85791473
155ESRRB_18555785_Chip-Seq_ESCs_Mouse0.85601800
156RNF2_27304074_Chip-Seq_NSC_Mouse0.85534471
157CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85457082
158TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85238968
159EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.81393242
160GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80887712
161* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.80885684
162RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80404627
163RBPJ_22232070_ChIP-Seq_NCS_Mouse0.80379543
164PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80162819
165STAT3_18555785_Chip-Seq_ESCs_Mouse0.79825573
166STAT1_20625510_ChIP-Seq_HELA_Human0.79660458
167GATA3_26560356_Chip-Seq_TH1_Human0.79389258

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive6.03008020
2* MP0001929_abnormal_gametogenesis5.60162140
3MP0008877_abnormal_DNA_methylation5.28616432
4MP0002210_abnormal_sex_determination3.90393297
5MP0002653_abnormal_ependyma_morphology3.32566057
6MP0001145_abnormal_male_reproductive3.28835220
7* MP0002161_abnormal_fertility/fecundity3.25770279
8MP0000653_abnormal_sex_gland2.85057052
9MP0000372_irregular_coat_pigmentation2.21448921
10MP0003195_calcinosis2.12532387
11MP0003136_yellow_coat_color2.04188218
12MP0003880_abnormal_central_pattern2.03500557
13MP0003718_maternal_effect2.01635678
14MP0005623_abnormal_meninges_morphology2.00528210
15MP0005670_abnormal_white_adipose2.00284024
16* MP0005410_abnormal_fertilization15.1411436
17MP0002160_abnormal_reproductive_system1.98604483
18MP0005646_abnormal_pituitary_gland1.94263997
19MP0001968_abnormal_touch/_nociception1.93678170
20MP0002736_abnormal_nociception_after1.92437145
21MP0008057_abnormal_DNA_replication1.91440575
22MP0004742_abnormal_vestibular_system1.91096244
23MP0001486_abnormal_startle_reflex1.83079778
24MP0002102_abnormal_ear_morphology1.65553826
25MP0008789_abnormal_olfactory_epithelium1.64650073
26MP0002138_abnormal_hepatobiliary_system1.61010648
27MP0006292_abnormal_olfactory_placode1.59859882
28MP0006276_abnormal_autonomic_nervous1.58753165
29MP0001501_abnormal_sleep_pattern1.55229320
30MP0008872_abnormal_physiological_respon1.53264681
31MP0008058_abnormal_DNA_repair1.51796023
32MP0000427_abnormal_hair_cycle1.49689872
33MP0002938_white_spotting1.49247069
34MP0002837_dystrophic_cardiac_calcinosis1.47099629
35MP0009745_abnormal_behavioral_response1.46951223
36MP0002876_abnormal_thyroid_physiology1.41542654
37MP0000631_abnormal_neuroendocrine_gland1.40346295
38MP0003646_muscle_fatigue1.39831261
39MP0010094_abnormal_chromosome_stability1.39557781
40MP0005645_abnormal_hypothalamus_physiol1.39432614
41MP0003787_abnormal_imprinting1.31968924
42MP0002272_abnormal_nervous_system1.29729511
43MP0001485_abnormal_pinna_reflex1.29071735
44MP0005174_abnormal_tail_pigmentation1.25135097
45MP0002282_abnormal_trachea_morphology1.22293975
46MP0005647_abnormal_sex_gland1.20370321
47MP0005310_abnormal_salivary_gland1.19658782
48MP0005085_abnormal_gallbladder_physiolo1.19617755
49MP0002095_abnormal_skin_pigmentation1.19301695
50MP0002735_abnormal_chemical_nociception1.18381494
51MP0001529_abnormal_vocalization1.16906277
52MP0005395_other_phenotype1.15692694
53MP0004233_abnormal_muscle_weight1.12564079
54MP0004885_abnormal_endolymph1.12469514
55MP0005389_reproductive_system_phenotype1.08356746
56MP0001984_abnormal_olfaction1.07961739
57MP0005075_abnormal_melanosome_morpholog1.07001121
58MP0005499_abnormal_olfactory_system1.06942562
59MP0005394_taste/olfaction_phenotype1.06942562
60MP0004147_increased_porphyrin_level1.06550628
61MP0002557_abnormal_social/conspecific_i1.06109142
62MP0004142_abnormal_muscle_tone1.05628855
63MP0002572_abnormal_emotion/affect_behav1.04873898
64MP0002751_abnormal_autonomic_nervous1.01736237
65MP0009697_abnormal_copulation1.01401683
66MP0001765_abnormal_ion_homeostasis0.99383124
67MP0005171_absent_coat_pigmentation0.97228002
68MP0002067_abnormal_sensory_capabilities0.97059724
69MP0004215_abnormal_myocardial_fiber0.96834492
70MP0005386_behavior/neurological_phenoty0.96464467
71MP0004924_abnormal_behavior0.96464467
72MP0003011_delayed_dark_adaptation0.92611083
73MP0008995_early_reproductive_senescence0.92152504
74MP0001970_abnormal_pain_threshold0.91863597
75MP0009046_muscle_twitch0.89466948
76MP0002638_abnormal_pupillary_reflex0.89229263
77MP0008007_abnormal_cellular_replicative0.88875904
78MP0003786_premature_aging0.88598728
79MP0003878_abnormal_ear_physiology0.88357718
80MP0005377_hearing/vestibular/ear_phenot0.88357718
81MP0002254_reproductive_system_inflammat0.86476442
82MP0000778_abnormal_nervous_system0.85595743
83MP0003111_abnormal_nucleus_morphology0.85456999
84MP0008875_abnormal_xenobiotic_pharmacok0.84496312
85MP0000647_abnormal_sebaceous_gland0.83885110
86MP0002733_abnormal_thermal_nociception0.83483474
87MP0005167_abnormal_blood-brain_barrier0.82217480
88MP0002064_seizures0.82153122
89MP0000516_abnormal_urinary_system0.81874640
90MP0005367_renal/urinary_system_phenotyp0.81874640
91MP0000026_abnormal_inner_ear0.80929543
92MP0003635_abnormal_synaptic_transmissio0.80558382
93MP0002168_other_aberrant_phenotype0.80344622
94MP0003121_genomic_imprinting0.78337134
95MP0002229_neurodegeneration0.78038840
96MP0000383_abnormal_hair_follicle0.77248435
97MP0001963_abnormal_hearing_physiology0.76740405
98MP0000358_abnormal_cell_content/0.74253053
99MP0001545_abnormal_hematopoietic_system0.71209239
100MP0005397_hematopoietic_system_phenotyp0.71209239
101MP0004808_abnormal_hematopoietic_stem0.66954070
102MP0000569_abnormal_digit_pigmentation0.61570945
103MP0010307_abnormal_tumor_latency0.57944198
104MP0005636_abnormal_mineral_homeostasis0.55636984
105MP0003699_abnormal_female_reproductive0.55369645
106MP0009278_abnormal_bone_marrow0.55053004
107MP0001730_embryonic_growth_arrest0.54895183
108MP0003077_abnormal_cell_cycle0.54603917
109MP0003950_abnormal_plasma_membrane0.52428228
110MP0001119_abnormal_female_reproductive0.48499014
111MP0002928_abnormal_bile_duct0.45069578
112MP0003693_abnormal_embryo_hatching0.45048303
113MP0003115_abnormal_respiratory_system0.44752629
114MP0004134_abnormal_chest_morphology0.44218027
115MP0002234_abnormal_pharynx_morphology0.43790668
116MP0001293_anophthalmia0.43429253
117MP0004264_abnormal_extraembryonic_tissu0.42265153
118MP0006036_abnormal_mitochondrial_physio0.42234886
119MP0005666_abnormal_adipose_tissue0.41317019
120MP0000313_abnormal_cell_death0.40786126
121MP0005253_abnormal_eye_physiology0.38344423
122MP0001764_abnormal_homeostasis0.38275834
123MP0003329_amyloid_beta_deposits0.38149423
124MP0002405_respiratory_system_inflammati0.35928616
125MP0005391_vision/eye_phenotype0.34978201
126MP0001324_abnormal_eye_pigmentation0.34610070
127MP0003763_abnormal_thymus_physiology0.32758977
128MP0009115_abnormal_fat_cell0.32128690
129MP0004036_abnormal_muscle_relaxation0.31138349
130MP0002269_muscular_atrophy0.30150321
131MP0004019_abnormal_vitamin_homeostasis0.29415991
132MP0002132_abnormal_respiratory_system0.28785511
133MP0005423_abnormal_somatic_nervous0.26712047
134MP0006035_abnormal_mitochondrial_morpho0.26574027
135MP0002971_abnormal_brown_adipose0.26480014
136MP0005380_embryogenesis_phenotype0.26414966
137MP0001672_abnormal_embryogenesis/_devel0.26414966
138MP0005551_abnormal_eye_electrophysiolog0.26080571
139MP0002084_abnormal_developmental_patter0.25575599
140MP0003045_fibrosis0.25039111
141MP0002092_abnormal_eye_morphology0.23514081
142MP0001727_abnormal_embryo_implantation0.23444316
143MP0001661_extended_life_span0.22623307
144MP0002080_prenatal_lethality0.22077170
145MP0001697_abnormal_embryo_size0.21827596
146MP0004043_abnormal_pH_regulation0.21091956
147MP0003861_abnormal_nervous_system0.20658112
148MP0000015_abnormal_ear_pigmentation0.20462880
149MP0006072_abnormal_retinal_apoptosis0.20156282
150MP0004957_abnormal_blastocyst_morpholog0.19788138
151MP0003984_embryonic_growth_retardation0.19393590
152MP0002169_no_abnormal_phenotype0.19315075
153MP0000703_abnormal_thymus_morphology0.18953461
154MP0002873_normal_phenotype0.18922371
155MP0003633_abnormal_nervous_system0.18261689
156MP0001851_eye_inflammation0.18049269
157MP0008961_abnormal_basal_metabolism0.17754741
158MP0002152_abnormal_brain_morphology0.17565251
159MP0000604_amyloidosis0.17343149
160MP0002088_abnormal_embryonic_growth/wei0.17087526
161MP0002398_abnormal_bone_marrow0.16344664
162MP0001919_abnormal_reproductive_system0.16337981
163MP0003936_abnormal_reproductive_system0.16227321
164MP0002019_abnormal_tumor_incidence0.14838306
165MP0003631_nervous_system_phenotype0.14546527
166MP0000001_mammalian_phenotype0.14311554
167MP0001986_abnormal_taste_sensitivity0.14213312

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.45284538
2Abnormal respiratory motile cilium morphology (HP:0005938)8.91483628
3Abnormal respiratory epithelium morphology (HP:0012253)8.91483628
4Rhinitis (HP:0012384)8.02688814
5Abnormal ciliary motility (HP:0012262)7.59241566
6Chronic bronchitis (HP:0004469)7.38193972
7Nasal polyposis (HP:0100582)6.80675071
8Infertility (HP:0000789)6.51564755
9Abnormality of the nasal mucosa (HP:0000433)5.56436890
10Bronchitis (HP:0012387)4.87264144
11Bronchiectasis (HP:0002110)4.85891451
12Nephronophthisis (HP:0000090)4.42891669
13Type II lissencephaly (HP:0007260)4.11145507
14Pancreatic cysts (HP:0001737)3.92243953
15Recurrent sinusitis (HP:0011108)3.76640833
16Recurrent otitis media (HP:0000403)3.60446204
17Male infertility (HP:0003251)3.48766893
18Abnormality of the renal medulla (HP:0100957)3.37490918
19Gaze-evoked nystagmus (HP:0000640)3.33133658
20Chronic hepatic failure (HP:0100626)3.28774859
21Abnormality of the lower motor neuron (HP:0002366)3.22778392
22True hermaphroditism (HP:0010459)3.22646871
23Recurrent bronchitis (HP:0002837)3.19977593
24Abnormal spermatogenesis (HP:0008669)3.11135916
25Congenital stationary night blindness (HP:0007642)3.06600788
26Attenuation of retinal blood vessels (HP:0007843)3.05729589
27Retinal dysplasia (HP:0007973)3.04301973
28Gonadotropin excess (HP:0000837)2.98710683
29Tubulointerstitial nephritis (HP:0001970)2.87502987
30Abnormality of midbrain morphology (HP:0002418)2.62734588
31Molar tooth sign on MRI (HP:0002419)2.62734588
32Amyotrophic lateral sclerosis (HP:0007354)2.62573693
33Aplasia/Hypoplasia of the tibia (HP:0005772)2.56932146
34Volvulus (HP:0002580)2.55931190
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.55802472
36Impulsivity (HP:0100710)2.54900753
37Nephrogenic diabetes insipidus (HP:0009806)2.53728253
38Tubular atrophy (HP:0000092)2.48047259
39Lissencephaly (HP:0001339)2.47336526
40Abnormality of macular pigmentation (HP:0008002)2.46219651
41Medial flaring of the eyebrow (HP:0010747)2.45791039
42Abnormality of chromosome stability (HP:0003220)2.40672369
43Renal cortical cysts (HP:0000803)2.39894391
44Tubulointerstitial abnormality (HP:0001969)2.39677151
45Genital tract atresia (HP:0001827)2.39347015
46Hypoproteinemia (HP:0003075)2.38225424
47Fibular hypoplasia (HP:0003038)2.30973829
48Azoospermia (HP:0000027)2.30755779
49Pendular nystagmus (HP:0012043)2.29838763
50Hyperventilation (HP:0002883)2.27932934
51Bony spicule pigmentary retinopathy (HP:0007737)2.27607422
52Absent speech (HP:0001344)2.27029045
53Thyroiditis (HP:0100646)2.24271566
54Abnormal rod and cone electroretinograms (HP:0008323)2.18889171
55Vaginal atresia (HP:0000148)2.18512496
56Abnormality of B cell number (HP:0010975)2.16317994
57Congenital sensorineural hearing impairment (HP:0008527)2.14713408
58Focal motor seizures (HP:0011153)2.14515500
59Impaired proprioception (HP:0010831)2.14298929
60Hypoplasia of the capital femoral epiphysis (HP:0003090)2.11949536
61Meckel diverticulum (HP:0002245)2.10715261
62Progressive inability to walk (HP:0002505)2.10178444
63Optic nerve hypoplasia (HP:0000609)2.09922553
64Postaxial foot polydactyly (HP:0001830)2.09627813
65Abnormality of the ileum (HP:0001549)2.09419832
66Chromsome breakage (HP:0040012)2.07407138
67Inability to walk (HP:0002540)2.06857552
68Hypoplasia of the pons (HP:0012110)2.02434019
69Progressive cerebellar ataxia (HP:0002073)2.02272340
70Astigmatism (HP:0000483)2.02238204
71Abnormality of alanine metabolism (HP:0010916)2.01687592
72Hyperalaninemia (HP:0003348)2.01687592
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01687592
74Keratoconus (HP:0000563)2.00564304
75Increased corneal curvature (HP:0100692)2.00564304
76Abnormality of the pons (HP:0007361)2.00275724
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.7032027
78Dynein arm defect of respiratory motile cilia (HP:0012255)12.7430103
79Absent/shortened dynein arms (HP:0200106)12.7430103
80Retinitis pigmentosa (HP:0000510)1.97959872
81Chromosomal breakage induced by crosslinking agents (HP:0003221)1.97380760
82Abnormal glycosylation (HP:0012345)1.96291441
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96291441
84Abnormal protein N-linked glycosylation (HP:0012347)1.96291441
85Abnormal protein glycosylation (HP:0012346)1.96291441
86Methylmalonic acidemia (HP:0002912)1.96249131
87B lymphocytopenia (HP:0010976)1.93455613
88Abolished electroretinogram (ERG) (HP:0000550)1.90163451
89Stage 5 chronic kidney disease (HP:0003774)1.89347182
90Aplasia/Hypoplasia of the fovea (HP:0008060)1.88826047
91Hypoplasia of the fovea (HP:0007750)1.88826047
92Chronic sinusitis (HP:0011109)1.88588860
93Narrow forehead (HP:0000341)1.88491281
94Clubbing of toes (HP:0100760)1.88247624
95Tubulointerstitial fibrosis (HP:0005576)1.88015049
96Small hand (HP:0200055)1.87977158
97Hypoplastic iliac wings (HP:0002866)1.87659026
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87500713
99Abnormality of the renal cortex (HP:0011035)1.87235890
100Poor coordination (HP:0002370)1.87076734
101Absent frontal sinuses (HP:0002688)1.86609021
102Spastic tetraparesis (HP:0001285)1.85984928
103Preaxial hand polydactyly (HP:0001177)1.84698948
104Severe visual impairment (HP:0001141)1.83341468
105Hyperglycinemia (HP:0002154)1.83112104
106Short ribs (HP:0000773)1.80912752
107Short tibia (HP:0005736)1.80704854
108Microglossia (HP:0000171)1.80682212
109Congenital hepatic fibrosis (HP:0002612)1.80339420
110Upper motor neuron abnormality (HP:0002127)1.78914151
111Dandy-Walker malformation (HP:0001305)1.78425953
112Degeneration of anterior horn cells (HP:0002398)1.78336133
113Abnormality of the anterior horn cell (HP:0006802)1.78336133
114Albinism (HP:0001022)1.77441234
115Focal seizures (HP:0007359)1.76166832
116J-shaped sella turcica (HP:0002680)1.75794572
117Oligodactyly (hands) (HP:0001180)1.75493396
118Constricted visual fields (HP:0001133)1.74677612
119Abnormal drinking behavior (HP:0030082)1.73858255
120Polydipsia (HP:0001959)1.73858255
121Sclerocornea (HP:0000647)1.71072294
122Intestinal atresia (HP:0011100)1.70518830
123Anencephaly (HP:0002323)1.70149190
124Aganglionic megacolon (HP:0002251)1.70072737
125Oculomotor apraxia (HP:0000657)1.69865905
126Abnormality of the dental root (HP:0006486)1.68707464
127Taurodontia (HP:0000679)1.68707464
128Abnormality of permanent molar morphology (HP:0011071)1.68707464
129Absent epiphyses (HP:0010577)1.65889657
130Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65889657
131Renal dysplasia (HP:0000110)1.64120298
132Abnormal gallbladder physiology (HP:0012438)1.63880102
133Cholecystitis (HP:0001082)1.63880102
134Facial cleft (HP:0002006)1.63336093
135Abnormality of dentin (HP:0010299)1.61704845
136Heterotopia (HP:0002282)1.61267063
137Abnormality of renal excretion (HP:0011036)1.60559833
138Abnormality of the dental pulp (HP:0006479)1.57844329
139Postaxial hand polydactyly (HP:0001162)1.57213313
140Aplasia/Hypoplasia of the fibula (HP:0006492)1.55444858
141Abnormality of molar (HP:0011077)1.55193334
142Abnormality of molar morphology (HP:0011070)1.55193334
143Supernumerary spleens (HP:0009799)1.52779791
144Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.48253799
145Deformed sella turcica (HP:0002681)1.43234750
146Bell-shaped thorax (HP:0001591)1.42593657
147Short thorax (HP:0010306)1.41171562
14811 pairs of ribs (HP:0000878)1.39328380
149Abnormal biliary tract physiology (HP:0012439)1.39092948
150Bile duct proliferation (HP:0001408)1.39092948
151Aplasia/Hypoplasia of the tongue (HP:0010295)1.38952121
152Broad distal phalanx of finger (HP:0009836)1.37719894
153Dyschromatopsia (HP:0007641)1.35376316
154Median cleft lip (HP:0000161)1.34843444
155Cystic liver disease (HP:0006706)1.34510767
156Nephropathy (HP:0000112)1.32313207
157Congenital primary aphakia (HP:0007707)1.31446000
158Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.31333549
159Gait imbalance (HP:0002141)1.29152079
160Abnormal urine output (HP:0012590)1.28354496
161Pancreatic fibrosis (HP:0100732)1.26326770
162Selective tooth agenesis (HP:0001592)1.24963377
163Hemiparesis (HP:0001269)1.21906659
164Breast carcinoma (HP:0003002)1.21858804
165Short femoral neck (HP:0100864)1.21055981
166Abnormality of ocular smooth pursuit (HP:0000617)1.20557131
167Aplasia/Hypoplasia of the lens (HP:0008063)1.19332429
168Decreased central vision (HP:0007663)1.18213508
169Pachygyria (HP:0001302)1.15180639
170Sloping forehead (HP:0000340)1.13989260
171Cerebellar dysplasia (HP:0007033)1.13532782
172Vascular calcification (HP:0004934)1.11996659
173Polyuria (HP:0000103)1.11798420

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.90287733
2PDK48.90287733
3FRK5.86589323
4PDK25.77477102
5TESK14.88758592
6MAP4K24.12448055
7PRKD33.86544572
8ICK3.37244300
9NUAK13.00493970
10EIF2AK32.48836919
11PNCK2.40532853
12WNK42.38802746
13PTK2B2.35972265
14LATS12.27014213
15STK392.24728248
16CASK2.14456519
17ZAK2.12525440
18NEK22.06831505
19MAPK132.03333441
20TRIM281.99558743
21CDK191.87078387
22MAP3K41.85198982
23ADRBK21.75274808
24GRK11.67610157
25INSRR1.61060121
26ACVR1B1.54354339
27STK381.46127604
28OXSR11.41743396
29PLK21.40452450
30MARK11.31492311
31EPHA41.17238763
32CCNB11.14712248
33TNK21.13866688
34MKNK21.09141396
35MAPK151.07873640
36DYRK1B1.07048028
37WNK11.06982984
38MKNK11.04757024
39ERBB31.02934534
40PAK31.01918372
41STK30.98322003
42PASK0.98245441
43CSNK1G10.95364769
44MAP2K70.94631880
45TYRO30.94507526
46PDK10.94106920
47VRK10.92715649
48BCR0.92284932
49PIK3CG0.92114477
50NTRK30.90560910
51PRKCE0.84269946
52CDC70.83718700
53DYRK30.83521239
54TNIK0.82107491
55CSNK1G20.82104917
56CSNK1G30.81368236
57TTK0.79054302
58WEE10.76051167
59TXK0.75852372
60PKN10.74333790
61PLK30.71805165
62EEF2K0.70631971
63IRAK10.65722180
64BMPR1B0.64549699
65MST40.64265712
66TAOK30.63994812
67FER0.63031069
68CSNK1A1L0.62285003
69DAPK20.60973792
70KIT0.60767790
71CHEK20.59728847
72TSSK60.58900756
73CHEK10.57506731
74TESK20.55490310
75TEC0.54868269
76DYRK20.54600856
77NLK0.54070358
78ATR0.52743170
79TGFBR10.51195394
80TLK10.51046676
81ADRBK10.49209687
82BRD40.47714233
83CAMK1G0.47069171
84PINK10.46439736
85BCKDK0.43975379
86NEK10.41675742
87CAMK2A0.41496692
88PRKCI0.41398063
89CDK120.38913035
90ATM0.37500567
91PDPK10.36720209
92KSR10.36399879
93BLK0.36150251
94MAP2K60.36121015
95AKT30.35421066
96PLK40.35027865
97RPS6KA50.34768608
98LMTK20.34618563
99PLK10.34131500
100PAK10.32341151
101STK38L0.31527888
102CAMKK20.31203301
103MAP3K90.31095826
104ROCK10.30442952
105CSNK1A10.29781621
106IKBKB0.29697595
107MTOR0.29143719
108PRKACA0.28234089
109MAP4K10.28110110
110BRSK20.27969267
111NTRK20.27837300
112RPS6KA40.27714739
113CSNK1E0.27298428
114MAPKAPK50.23991320
115STK100.22030627
116PRKAA10.21851508
117PRKCG0.21397348
118CSF1R0.19198154
119RPS6KB10.18689938
120MAP3K100.17922374
121MARK20.17571325
122ZAP700.17304523
123PAK20.17186336
124IRAK20.16944587
125MUSK0.16166829
126CAMKK10.14195538
127PRKCQ0.14020678
128BRAF0.13353370
129RIPK40.12980896
130RIPK10.11942834
131BRSK10.10968534
132CDK20.08290879
133BUB10.08180952
134CDK10.07936604
135TAOK10.07930542
136NEK60.07280773
137CDK40.06935680
138CSNK2A10.06499809
139MARK30.05989849
140RPS6KA10.04983386
141ERN10.04410316
142GSK3B0.04265397
143CSNK1D0.04215734
144CDK150.04024673
145WNK30.03568264
146MAPK80.03501169
147PIM10.03092439
148PRKDC0.02341990
149CSNK2A20.02110906
150CSK0.01958582
151PRKCZ0.01707623
152CDK11A0.01461745
153CDK180.01324182
154PRKACG0.00407713
155PRKG10.00396444
156PRKG20.00198664
157PRKCA-0.0377592
158MAPK1-0.0325658
159PDGFRB-0.0299142
160CDK6-0.0294699
161PAK4-0.0260114
162PRKCB-0.0257927
163AURKA-0.0213743
164AURKB-0.0197128
165CDK3-0.0157329
166EGFR-0.0065127
167PRKACB-0.0063104

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.03038998
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.27144112
3Pyruvate metabolism_Homo sapiens_hsa006204.17939954
4Fatty acid biosynthesis_Homo sapiens_hsa000613.26126987
5Propanoate metabolism_Homo sapiens_hsa006403.14932529
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.87672001
7Basal transcription factors_Homo sapiens_hsa030222.83106317
8Glucagon signaling pathway_Homo sapiens_hsa049222.76820983
9Butanoate metabolism_Homo sapiens_hsa006502.58693573
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.54878679
11Pentose phosphate pathway_Homo sapiens_hsa000302.54780773
12Fanconi anemia pathway_Homo sapiens_hsa034602.44381843
13Linoleic acid metabolism_Homo sapiens_hsa005912.44225067
14Selenocompound metabolism_Homo sapiens_hsa004502.44025257
15Dorso-ventral axis formation_Homo sapiens_hsa043202.39141882
16Phototransduction_Homo sapiens_hsa047442.37747945
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.35738069
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.24283761
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15335956
20Glycerolipid metabolism_Homo sapiens_hsa005612.06286403
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05939786
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.05650261
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.95193434
24Oocyte meiosis_Homo sapiens_hsa041141.95129474
25Carbohydrate digestion and absorption_Homo sapiens_hsa049731.93126409
26Nicotine addiction_Homo sapiens_hsa050331.88882006
27Tryptophan metabolism_Homo sapiens_hsa003801.87708830
28Protein export_Homo sapiens_hsa030601.80111248
29Caffeine metabolism_Homo sapiens_hsa002321.78348321
30Nitrogen metabolism_Homo sapiens_hsa009101.75062116
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.68207001
32Fructose and mannose metabolism_Homo sapiens_hsa000511.62990991
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.60644436
34Huntingtons disease_Homo sapiens_hsa050161.59450467
35PPAR signaling pathway_Homo sapiens_hsa033201.58834543
36mRNA surveillance pathway_Homo sapiens_hsa030151.50055761
37RNA transport_Homo sapiens_hsa030131.47948921
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.46363680
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46256793
40Antigen processing and presentation_Homo sapiens_hsa046121.39547330
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.38873373
42Carbon metabolism_Homo sapiens_hsa012001.38561627
43Amphetamine addiction_Homo sapiens_hsa050311.37746721
44Olfactory transduction_Homo sapiens_hsa047401.35943272
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.35542790
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34987105
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.29760309
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29078396
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23055434
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.22314096
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.19117975
52Regulation of autophagy_Homo sapiens_hsa041401.18725858
53Renin secretion_Homo sapiens_hsa049241.13897072
54beta-Alanine metabolism_Homo sapiens_hsa004101.12471277
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12425376
56Purine metabolism_Homo sapiens_hsa002301.11915561
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11309260
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08724396
59Lysine degradation_Homo sapiens_hsa003101.08617190
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05041187
61Mismatch repair_Homo sapiens_hsa034301.03781093
62Ether lipid metabolism_Homo sapiens_hsa005651.03682221
63Steroid biosynthesis_Homo sapiens_hsa001001.02090432
64Cardiac muscle contraction_Homo sapiens_hsa042601.01573367
65RNA polymerase_Homo sapiens_hsa030201.01054821
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99635096
67Fatty acid metabolism_Homo sapiens_hsa012120.98082981
68Fat digestion and absorption_Homo sapiens_hsa049750.96941326
69Fatty acid degradation_Homo sapiens_hsa000710.95279456
70Biosynthesis of amino acids_Homo sapiens_hsa012300.93757506
71Primary immunodeficiency_Homo sapiens_hsa053400.91197745
72ABC transporters_Homo sapiens_hsa020100.90648253
73Nucleotide excision repair_Homo sapiens_hsa034200.88600266
74Mineral absorption_Homo sapiens_hsa049780.87086572
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86828235
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85632208
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85186865
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83542886
79Peroxisome_Homo sapiens_hsa041460.79644760
80Circadian rhythm_Homo sapiens_hsa047100.78549254
81Morphine addiction_Homo sapiens_hsa050320.78471781
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.78392421
83Glutamatergic synapse_Homo sapiens_hsa047240.77713418
84Glutathione metabolism_Homo sapiens_hsa004800.75531187
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74683282
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.73932293
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73816671
88RNA degradation_Homo sapiens_hsa030180.73010790
89One carbon pool by folate_Homo sapiens_hsa006700.71096560
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66349403
91Chemical carcinogenesis_Homo sapiens_hsa052040.65923623
92Sulfur metabolism_Homo sapiens_hsa009200.65581290
93Serotonergic synapse_Homo sapiens_hsa047260.65054455
94Ovarian steroidogenesis_Homo sapiens_hsa049130.64661150
95GABAergic synapse_Homo sapiens_hsa047270.64275718
96Long-term potentiation_Homo sapiens_hsa047200.62159347
97B cell receptor signaling pathway_Homo sapiens_hsa046620.61645313
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.60572915
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60301132
100Circadian entrainment_Homo sapiens_hsa047130.59377298
101N-Glycan biosynthesis_Homo sapiens_hsa005100.56939599
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.56236393
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55195041
104Pyrimidine metabolism_Homo sapiens_hsa002400.54442246
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52303347
106Arachidonic acid metabolism_Homo sapiens_hsa005900.52208273
107Estrogen signaling pathway_Homo sapiens_hsa049150.51646303
108Homologous recombination_Homo sapiens_hsa034400.51086344
109Legionellosis_Homo sapiens_hsa051340.50892488
110Long-term depression_Homo sapiens_hsa047300.50723468
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.47498797
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47197297
113Renin-angiotensin system_Homo sapiens_hsa046140.45827446
114VEGF signaling pathway_Homo sapiens_hsa043700.44869666
115Hedgehog signaling pathway_Homo sapiens_hsa043400.44045309
116Inositol phosphate metabolism_Homo sapiens_hsa005620.43798065
117Asthma_Homo sapiens_hsa053100.43564057
118Cell cycle_Homo sapiens_hsa041100.43438476
119AMPK signaling pathway_Homo sapiens_hsa041520.41996546
120Fatty acid elongation_Homo sapiens_hsa000620.41996056
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41966056
122Systemic lupus erythematosus_Homo sapiens_hsa053220.41747335
123Bile secretion_Homo sapiens_hsa049760.41372963
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41360461
125Endocytosis_Homo sapiens_hsa041440.41258362
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.41056577
127Thyroid hormone synthesis_Homo sapiens_hsa049180.40544562
128Insulin secretion_Homo sapiens_hsa049110.39959336
129Calcium signaling pathway_Homo sapiens_hsa040200.39186127
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36891209
131Sphingolipid metabolism_Homo sapiens_hsa006000.36708649
132Metabolic pathways_Homo sapiens_hsa011000.34419484
133DNA replication_Homo sapiens_hsa030300.33864535
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33356279
135Proteasome_Homo sapiens_hsa030500.31562085
136Collecting duct acid secretion_Homo sapiens_hsa049660.31196974
137Autoimmune thyroid disease_Homo sapiens_hsa053200.30736049
138Dopaminergic synapse_Homo sapiens_hsa047280.29008694
139Non-homologous end-joining_Homo sapiens_hsa034500.28801212
140p53 signaling pathway_Homo sapiens_hsa041150.28766121
141T cell receptor signaling pathway_Homo sapiens_hsa046600.27802638
142Histidine metabolism_Homo sapiens_hsa003400.27303529
143Viral carcinogenesis_Homo sapiens_hsa052030.21197123
144Base excision repair_Homo sapiens_hsa034100.20629247
145Epstein-Barr virus infection_Homo sapiens_hsa051690.20340454
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19877942
147Pancreatic secretion_Homo sapiens_hsa049720.19744827
148Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.15131669
149Vascular smooth muscle contraction_Homo sapiens_hsa042700.15043602
150Spliceosome_Homo sapiens_hsa030400.14733076
151Taste transduction_Homo sapiens_hsa047420.14367513
152HTLV-I infection_Homo sapiens_hsa051660.13249737
153Protein digestion and absorption_Homo sapiens_hsa049740.12934094
154Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.11875684
155Salivary secretion_Homo sapiens_hsa049700.11155678
156Retinol metabolism_Homo sapiens_hsa008300.09502520
157Alcoholism_Homo sapiens_hsa050340.08878301

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