ZPLD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1auditory receptor cell differentiation (GO:0042491)8.59286993
2female gonad development (GO:0008585)5.94592557
3righting reflex (GO:0060013)5.64730354
4hair cell differentiation (GO:0035315)5.62633253
5cytidine deamination (GO:0009972)5.56944906
6cytidine metabolic process (GO:0046087)5.56944906
7cytidine catabolic process (GO:0006216)5.56944906
8inositol phosphate dephosphorylation (GO:0046855)5.51381957
9phosphorylated carbohydrate dephosphorylation (GO:0046838)5.51381957
10inositol phosphate catabolic process (GO:0071545)5.46612155
11platelet dense granule organization (GO:0060155)5.30610777
12diterpenoid biosynthetic process (GO:0016102)5.24865486
13calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.22083149
14pentose metabolic process (GO:0019321)5.12803316
15ketone body metabolic process (GO:1902224)5.07335950
16inner ear receptor cell differentiation (GO:0060113)4.98467782
17regulation of type B pancreatic cell apoptotic process (GO:2000674)4.95625536
18glyoxylate metabolic process (GO:0046487)4.83756501
19urate metabolic process (GO:0046415)4.81069283
20synaptic vesicle exocytosis (GO:0016079)4.71321870
21epoxygenase P450 pathway (GO:0019373)4.52312469
22protein-chromophore linkage (GO:0018298)4.50023897
23regulation of transforming growth factor beta2 production (GO:0032909)4.47648118
24negative regulation of hormone metabolic process (GO:0032351)4.42795000
25negative regulation of hormone biosynthetic process (GO:0032353)4.42795000
26pyrimidine ribonucleoside catabolic process (GO:0046133)4.32222021
27regulation of transmission of nerve impulse (GO:0051969)4.31789235
28polyol catabolic process (GO:0046174)4.26048648
29signal peptide processing (GO:0006465)4.16269240
30regulation of meiosis (GO:0040020)4.15950479
31G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.07028573
32sensory perception of sound (GO:0007605)3.93966716
33drug transmembrane transport (GO:0006855)3.89388064
34mechanoreceptor differentiation (GO:0042490)3.87991920
35sensory perception of mechanical stimulus (GO:0050954)3.87891013
36negative regulation of keratinocyte proliferation (GO:0010839)3.83857537
37melanosome transport (GO:0032402)3.81522183
38regulation of female gonad development (GO:2000194)3.80196874
39establishment of protein localization to Golgi (GO:0072600)3.68410323
40establishment of melanosome localization (GO:0032401)3.65328748
41retinal metabolic process (GO:0042574)3.63829009
42protein targeting to Golgi (GO:0000042)3.63013145
43pigment granule transport (GO:0051904)3.61857534
44protein localization to Golgi apparatus (GO:0034067)3.61738980
45drug catabolic process (GO:0042737)3.55397166
46cullin deneddylation (GO:0010388)3.52312408
47melanosome localization (GO:0032400)3.49880206
48inner ear morphogenesis (GO:0042472)3.48503169
49establishment of pigment granule localization (GO:0051905)3.47223146
50growth hormone receptor signaling pathway (GO:0060396)3.46731270
51myoblast migration (GO:0051451)3.42805336
52nephron tubule formation (GO:0072079)3.42470549
53kynurenine metabolic process (GO:0070189)3.41776682
54mitotic chromosome condensation (GO:0007076)3.41682843
55phenylpropanoid metabolic process (GO:0009698)3.39877265
56terpenoid biosynthetic process (GO:0016114)3.39485880
57reflex (GO:0060004)3.39319113
58photoreceptor cell maintenance (GO:0045494)3.38322742
59estrogen biosynthetic process (GO:0006703)3.37768320
60mitotic metaphase plate congression (GO:0007080)3.36106021
61melanosome organization (GO:0032438)3.33911600
62pigment granule localization (GO:0051875)3.33840995
63negative regulation of gluconeogenesis (GO:0045721)3.33684632
64metanephric tubule development (GO:0072170)3.32766222
65metanephric nephron tubule development (GO:0072234)3.32766222
66regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.31973600
67female gamete generation (GO:0007292)3.31161039
68anterograde synaptic vesicle transport (GO:0048490)3.30337463
69response to phenylpropanoid (GO:0080184)3.29078777
70artery smooth muscle contraction (GO:0014824)3.24605620
71endocrine pancreas development (GO:0031018)3.24482260
72positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.23202860
73vitamin D metabolic process (GO:0042359)3.22306511
74regulation of meiotic cell cycle (GO:0051445)3.22131310
75regulation of glucocorticoid metabolic process (GO:0031943)3.22085140
76retrograde transport, vesicle recycling within Golgi (GO:0000301)3.21582987
77excretion (GO:0007588)3.16575447
78regulation of steroid hormone biosynthetic process (GO:0090030)3.16036034
79regulation of keratinocyte proliferation (GO:0010837)3.15288877
80drug transport (GO:0015893)3.14580467
81regulation of acrosome reaction (GO:0060046)3.14172823
82negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.13877724
83oligosaccharide catabolic process (GO:0009313)3.13272426
84inositol phosphate-mediated signaling (GO:0048016)3.13241910
85regulation of sister chromatid cohesion (GO:0007063)3.07917046
86piRNA metabolic process (GO:0034587)3.07461794
87indole-containing compound catabolic process (GO:0042436)3.07138368
88indolalkylamine catabolic process (GO:0046218)3.07138368
89tryptophan catabolic process (GO:0006569)3.07138368
90retinal rod cell development (GO:0046548)3.07022276
91melanin biosynthetic process (GO:0042438)3.06673639
92mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.06319409
93positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.06319409
94metanephric nephron epithelium development (GO:0072243)3.02858212
95pigment granule organization (GO:0048753)3.02436063
96inner ear receptor cell development (GO:0060119)3.01697172
97mitotic sister chromatid cohesion (GO:0007064)3.01023061
98aromatic amino acid family catabolic process (GO:0009074)3.00131643
99protein K11-linked deubiquitination (GO:0035871)2.99965015
100protein localization to cilium (GO:0061512)2.99937613
101regulation of meiosis I (GO:0060631)2.98971130
102cellular response to growth hormone stimulus (GO:0071378)2.98803758
103detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.97438339
104tricarboxylic acid metabolic process (GO:0072350)2.95871868
105protein deneddylation (GO:0000338)2.94900030
106phasic smooth muscle contraction (GO:0014821)2.94843117
107tonic smooth muscle contraction (GO:0014820)2.94391074
108regulation of hexokinase activity (GO:1903299)2.93984836
109regulation of glucokinase activity (GO:0033131)2.93984836
110detection of mechanical stimulus (GO:0050982)2.93413234
111type B pancreatic cell development (GO:0003323)2.92794856
112erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.92249078
113L-phenylalanine catabolic process (GO:0006559)2.92249078
114histone H2A monoubiquitination (GO:0035518)2.92175777
115erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.92059312
116L-phenylalanine metabolic process (GO:0006558)2.92059312
117indolalkylamine metabolic process (GO:0006586)2.90748739
118organic cation transport (GO:0015695)2.90477914
119developmental pigmentation (GO:0048066)2.90359891
120cellular ketone body metabolic process (GO:0046950)2.88494442
121nephron epithelium morphogenesis (GO:0072088)2.87240723
122nephron tubule morphogenesis (GO:0072078)2.87240723
123cranial nerve morphogenesis (GO:0021602)2.86495032
124trivalent inorganic anion homeostasis (GO:0072506)2.85845375
125phosphate ion homeostasis (GO:0055062)2.85845375
126muscle cell migration (GO:0014812)2.84966819
127DNA methylation involved in gamete generation (GO:0043046)2.84063304
128respiratory chain complex IV assembly (GO:0008535)2.83943142
129nephron tubule development (GO:0072080)2.83385534
130regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.82988255
131secondary metabolite biosynthetic process (GO:0044550)2.81446749
132regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80713517
133behavioral response to nicotine (GO:0035095)2.80462896
134synapsis (GO:0007129)2.78867596
135aromatic amino acid family metabolic process (GO:0009072)2.78525893
136amine catabolic process (GO:0009310)2.78136009
137cellular biogenic amine catabolic process (GO:0042402)2.78136009
138negative regulation of cytosolic calcium ion concentration (GO:0051481)2.76715447
139oxidative demethylation (GO:0070989)2.75571506
140regulation of transforming growth factor beta1 production (GO:0032908)2.74643865
141neuromuscular process controlling balance (GO:0050885)2.74640898
142mannosylation (GO:0097502)2.74447644
143axoneme assembly (GO:0035082)2.73672619
144male genitalia development (GO:0030539)2.73530323
145histone H2A ubiquitination (GO:0033522)2.73141990
146endosome to pigment granule transport (GO:0043485)2.72179408
147endosome to melanosome transport (GO:0035646)2.72179408
148detection of light stimulus involved in visual perception (GO:0050908)2.71268407
149detection of light stimulus involved in sensory perception (GO:0050962)2.71268407
150interleukin-6-mediated signaling pathway (GO:0070102)2.70825342
151early endosome to late endosome transport (GO:0045022)2.70175611
152positive regulation of glycolytic process (GO:0045821)2.69193489
153positive regulation of neurological system process (GO:0031646)2.67858359
154tryptophan metabolic process (GO:0006568)2.67241844
155sphingoid metabolic process (GO:0046519)2.65693795
156face development (GO:0060324)2.65058988
157cell differentiation involved in metanephros development (GO:0072202)2.64164343
158cytoplasmic mRNA processing body assembly (GO:0033962)2.63904349
159phenol-containing compound biosynthetic process (GO:0046189)2.61905753
160asymmetric protein localization (GO:0008105)2.61645831
161metanephric epithelium development (GO:0072207)2.60806677
162generation of neurons (GO:0048699)2.60778746
163response to pheromone (GO:0019236)2.60606726
164neural tube formation (GO:0001841)2.60573119
165negative regulation of chemokine production (GO:0032682)2.58105875
166proline transport (GO:0015824)2.57333873
167regulation of secondary heart field cardioblast proliferation (GO:0003266)2.57312112
168regulation of cardioblast proliferation (GO:0003264)2.57312112
169xenobiotic catabolic process (GO:0042178)2.57308823
170metaphase plate congression (GO:0051310)2.56172461
171preassembly of GPI anchor in ER membrane (GO:0016254)2.56120135
172male sex determination (GO:0030238)2.55408617
173metanephric mesenchyme development (GO:0072075)2.55394426
174insulin secretion (GO:0030073)2.55184894
175keratinocyte development (GO:0003334)2.55003614
176exogenous drug catabolic process (GO:0042738)2.54897179
177oocyte development (GO:0048599)2.54890041
178regulation of neuron projection regeneration (GO:0070570)2.54393784
179regulation of axon regeneration (GO:0048679)2.54393784
180cysteine metabolic process (GO:0006534)2.52561128
181C-terminal protein amino acid modification (GO:0018410)2.51972082
182melanin metabolic process (GO:0006582)2.51238318
183multicellular organism reproduction (GO:0032504)2.50800401
184phosphorelay signal transduction system (GO:0000160)2.50549230
185inositol metabolic process (GO:0006020)2.50457905
186regulation of chemokine-mediated signaling pathway (GO:0070099)2.49329824
187magnesium ion transport (GO:0015693)2.48605764
188cytochrome complex assembly (GO:0017004)2.47578950
189tight junction assembly (GO:0070830)2.47483682
190transmission of nerve impulse (GO:0019226)2.47298828
191phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.47233514
192retinal ganglion cell axon guidance (GO:0031290)2.46283768
193meiotic cell cycle (GO:0051321)2.45657165
194oocyte maturation (GO:0001556)2.45058104
195phosphate ion transport (GO:0006817)2.44931010

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.16810087
2* VDR_22108803_ChIP-Seq_LS180_Human3.04007551
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.00020299
4GBX2_23144817_ChIP-Seq_PC3_Human2.45022211
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.40083742
6ZNF274_21170338_ChIP-Seq_K562_Hela2.32987929
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.26228289
8* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.25259849
9ZNF217_24962896_ChIP-Seq_MCF-7_Human2.15649572
10* PIAS1_25552417_ChIP-Seq_VCAP_Human2.13845215
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.10435835
12ER_23166858_ChIP-Seq_MCF-7_Human2.05228788
13AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.96438534
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96004826
15ESR1_20079471_ChIP-ChIP_T-47D_Human1.94635320
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81313966
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80450057
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79125947
19FUS_26573619_Chip-Seq_HEK293_Human1.78914295
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.76578057
21BCAT_22108803_ChIP-Seq_LS180_Human1.75304054
22* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73253051
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70838075
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69670165
25* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66830741
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66549636
27SMAD4_21799915_ChIP-Seq_A2780_Human1.64455016
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.62488951
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60861338
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60861338
31CBP_20019798_ChIP-Seq_JUKART_Human1.59999323
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.59999323
33FOXM1_26456572_ChIP-Seq_MCF-7_Human1.59239531
34TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57546346
35TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56399701
36POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.56399701
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55941094
38TAF15_26573619_Chip-Seq_HEK293_Human1.54822348
39AR_25329375_ChIP-Seq_VCAP_Human1.54533872
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.51821382
41NANOG_19829295_ChIP-Seq_ESCs_Human1.50834317
42SOX2_19829295_ChIP-Seq_ESCs_Human1.50834317
43TCF4_23295773_ChIP-Seq_U87_Human1.50796378
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49546184
45* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48560266
46* TP53_18474530_ChIP-ChIP_U2OS_Human1.48488719
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.45566531
48AR_21572438_ChIP-Seq_LNCaP_Human1.45109012
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44812315
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44179084
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.42285766
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42252910
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.41994137
54AHR_22903824_ChIP-Seq_MCF-7_Human1.41284877
55P300_19829295_ChIP-Seq_ESCs_Human1.40738051
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38797487
57MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38498012
58SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37926522
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37676160
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37313015
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.37254390
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36991266
63TP53_16413492_ChIP-PET_HCT116_Human1.36805623
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35864693
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.34476268
66* ARNT_22903824_ChIP-Seq_MCF-7_Human1.33721324
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33588923
68* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32963787
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.32308791
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32022473
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32002294
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31686854
73STAT3_23295773_ChIP-Seq_U87_Human1.31512097
74* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31460092
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30823513
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30579578
77CDX2_22108803_ChIP-Seq_LS180_Human1.30087675
78EZH2_27304074_Chip-Seq_ESCs_Mouse1.30026380
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.29603019
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.28826654
81* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28760959
82SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27733947
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27351992
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27261575
85IGF1R_20145208_ChIP-Seq_DFB_Human1.26899428
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26388830
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.26353866
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.26227654
89* AR_21909140_ChIP-Seq_LNCAP_Human1.26075302
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25887309
91VDR_24787735_ChIP-Seq_THP-1_Human1.25563491
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25453359
93P53_22387025_ChIP-Seq_ESCs_Mouse1.25380250
94CMYC_18555785_Chip-Seq_ESCs_Mouse1.24798557
95SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24761817
96TP53_22573176_ChIP-Seq_HFKS_Human1.24200016
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21787277
98NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21787277
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21563572
100SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20753799
101RUNX2_22187159_ChIP-Seq_PCA_Human1.20522823
102SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20264086
103* RXR_22108803_ChIP-Seq_LS180_Human1.19946294
104EED_16625203_ChIP-ChIP_MESCs_Mouse1.19870492
105ESR2_21235772_ChIP-Seq_MCF-7_Human1.19139853
106NCOR_22424771_ChIP-Seq_293T_Human1.18776041
107ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18728421
108NMYC_18555785_Chip-Seq_ESCs_Mouse1.17907514
109FOXA1_25329375_ChIP-Seq_VCAP_Human1.17424357
110FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17424357
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16831623
112* KDM2B_26808549_Chip-Seq_REH_Human1.16738143
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16365103
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.15806036
115SOX2_18555785_Chip-Seq_ESCs_Mouse1.15619738
116CJUN_26792858_Chip-Seq_BT549_Human1.15501643
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15481326
118P300_18555785_Chip-Seq_ESCs_Mouse1.15326882
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15252395
120JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15230981
121OCT4_18555785_Chip-Seq_ESCs_Mouse1.14502900
122* PRDM14_20953172_ChIP-Seq_ESCs_Human1.14190146
123TRIM28_21343339_ChIP-Seq_HEK293_Human1.14153327
124SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12692610
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12682567
126SMAD3_21741376_ChIP-Seq_HESCs_Human1.12636252
127RNF2_27304074_Chip-Seq_NSC_Mouse1.12617745
128CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12606789
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11954910
130NFYB_21822215_ChIP-Seq_K562_Human1.11811003
131HTT_18923047_ChIP-ChIP_STHdh_Human1.11746575
132CBX2_27304074_Chip-Seq_ESCs_Mouse1.11718304
133FLI1_27457419_Chip-Seq_LIVER_Mouse1.10634074
134WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10288037
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09591315
136* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09560398
137AR_20517297_ChIP-Seq_VCAP_Human1.08640795
138REST_21632747_ChIP-Seq_MESCs_Mouse1.07671100
139SMAD4_21741376_ChIP-Seq_HESCs_Human1.07470598
140KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07455216
141SOX2_21211035_ChIP-Seq_LN229_Gbm1.06901684
142FOXA1_25552417_ChIP-Seq_VCAP_Human1.05836024
143RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05572940
144JUN_21703547_ChIP-Seq_K562_Human1.05473563
145NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05352729
146ISL1_27105846_Chip-Seq_CPCs_Mouse1.05234253
147* TAL1_26923725_Chip-Seq_HPCs_Mouse1.05157700
148NANOG_18555785_Chip-Seq_ESCs_Mouse1.04862367
149TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04841349
150RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04687727
151* SMAD3_21741376_ChIP-Seq_EPCs_Human1.04071518
152* TCF4_22108803_ChIP-Seq_LS180_Human1.04032647
153CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03258543
154EWS_26573619_Chip-Seq_HEK293_Human1.03088802
155PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02987889
156EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02807781
157ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01649817

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003879_abnormal_hair_cell7.47676042
2MP0001485_abnormal_pinna_reflex6.95898293
3MP0005377_hearing/vestibular/ear_phenot6.47331244
4MP0003878_abnormal_ear_physiology6.47331244
5MP0003195_calcinosis4.36140587
6MP0000372_irregular_coat_pigmentation4.02444005
7MP0002638_abnormal_pupillary_reflex3.43552015
8MP0000026_abnormal_inner_ear3.27316870
9MP0005248_abnormal_Harderian_gland3.05700126
10MP0003011_delayed_dark_adaptation3.05696805
11MP0005075_abnormal_melanosome_morpholog3.05473190
12MP0002102_abnormal_ear_morphology2.99145892
13MP0005085_abnormal_gallbladder_physiolo2.81261762
14MP0001963_abnormal_hearing_physiology2.77433688
15MP0005360_urolithiasis2.60667356
16MP0005083_abnormal_biliary_tract2.55518180
17MP0003136_yellow_coat_color2.45568344
18MP0001486_abnormal_startle_reflex2.37191040
19MP0004742_abnormal_vestibular_system2.29296715
20MP0003718_maternal_effect2.23689895
21MP0002138_abnormal_hepatobiliary_system2.13739770
22MP0001501_abnormal_sleep_pattern2.13238785
23MP0005551_abnormal_eye_electrophysiolog2.03278104
24MP0001764_abnormal_homeostasis2.03144008
25MP0005365_abnormal_bile_salt1.97480406
26MP0002876_abnormal_thyroid_physiology1.94523744
27MP0004859_abnormal_synaptic_plasticity1.93728177
28MP0005253_abnormal_eye_physiology1.86832452
29MP0004043_abnormal_pH_regulation1.82542641
30MP0005379_endocrine/exocrine_gland_phen1.78845211
31MP0003950_abnormal_plasma_membrane1.76597209
32MP0005174_abnormal_tail_pigmentation1.74967088
33MP0003646_muscle_fatigue1.70509519
34MP0001765_abnormal_ion_homeostasis1.68355549
35MP0006072_abnormal_retinal_apoptosis1.67431515
36MP0005395_other_phenotype1.67051690
37MP0003938_abnormal_ear_development1.65962441
38MP0004270_analgesia1.62839953
39MP0000015_abnormal_ear_pigmentation1.60913764
40MP0001905_abnormal_dopamine_level1.60514491
41MP0001944_abnormal_pancreas_morphology1.56873831
42MP0004019_abnormal_vitamin_homeostasis1.56420523
43MP0002090_abnormal_vision1.54624296
44MP0002653_abnormal_ependyma_morphology1.51754380
45MP0008877_abnormal_DNA_methylation1.50746779
46MP0004885_abnormal_endolymph1.50378843
47MP0010234_abnormal_vibrissa_follicle1.44714435
48MP0005220_abnormal_exocrine_pancreas1.42104435
49MP0005451_abnormal_body_composition1.41648357
50MP0000371_diluted_coat_color1.35580801
51MP0002249_abnormal_larynx_morphology1.35040529
52MP0006082_CNS_inflammation1.31648909
53MP0006276_abnormal_autonomic_nervous1.30744671
54MP0004381_abnormal_hair_follicle1.30648531
55MP0005257_abnormal_intraocular_pressure1.30328829
56MP0002163_abnormal_gland_morphology1.30067574
57MP0002168_other_aberrant_phenotype1.29913150
58MP0001324_abnormal_eye_pigmentation1.29444721
59MP0003283_abnormal_digestive_organ1.26755235
60MP0003943_abnormal_hepatobiliary_system1.24204572
61MP0002693_abnormal_pancreas_physiology1.22189912
62MP0002938_white_spotting1.21123798
63MP0009384_cardiac_valve_regurgitation1.20485195
64MP0005171_absent_coat_pigmentation1.19085192
65MP0002095_abnormal_skin_pigmentation1.19046779
66MP0000427_abnormal_hair_cycle1.17927495
67MP0009745_abnormal_behavioral_response1.17761428
68MP0009697_abnormal_copulation1.17347556
69MP0005646_abnormal_pituitary_gland1.14730560
70MP0004134_abnormal_chest_morphology1.11522175
71MP0009046_muscle_twitch1.07239730
72MP0003868_abnormal_feces_composition1.05945349
73MP0003942_abnormal_urinary_system1.05387060
74MP0003122_maternal_imprinting1.04620856
75MP0005332_abnormal_amino_acid1.04430687
76MP0000569_abnormal_digit_pigmentation1.02763966
77MP0003941_abnormal_skin_development1.00757134
78MP0005084_abnormal_gallbladder_morpholo1.00429030
79MP0006292_abnormal_olfactory_placode0.99802238
80MP0002822_catalepsy0.99503114
81MP0002332_abnormal_exercise_endurance0.98332681
82MP0002877_abnormal_melanocyte_morpholog0.98131460
83MP0001346_abnormal_lacrimal_gland0.97461264
84MP0004924_abnormal_behavior0.97164731
85MP0005386_behavior/neurological_phenoty0.97164731
86MP0005410_abnormal_fertilization0.92808689
87MP0001984_abnormal_olfaction0.91913650
88MP0000538_abnormal_urinary_bladder0.91799153
89MP0002139_abnormal_hepatobiliary_system0.89693239
90MP0001756_abnormal_urination0.87977899
91MP0009250_abnormal_appendicular_skeleto0.87945008
92MP0000678_abnormal_parathyroid_gland0.86116976
93MP0000631_abnormal_neuroendocrine_gland0.86017980
94MP0001502_abnormal_circadian_rhythm0.85789710
95MP0003123_paternal_imprinting0.84862586
96MP0002272_abnormal_nervous_system0.84562099
97MP0008775_abnormal_heart_ventricle0.84395520
98MP0000534_abnormal_ureter_morphology0.82849395
99MP0001119_abnormal_female_reproductive0.82192629
100MP0001986_abnormal_taste_sensitivity0.80155080
101MP0005636_abnormal_mineral_homeostasis0.79209825
102MP0004142_abnormal_muscle_tone0.78388105
103MP0002282_abnormal_trachea_morphology0.77913624
104MP0002233_abnormal_nose_morphology0.77552059
105MP0002184_abnormal_innervation0.77260910
106MP0005187_abnormal_penis_morphology0.76200475
107MP0005408_hypopigmentation0.75705105
108MP0010386_abnormal_urinary_bladder0.75244894
109MP0002736_abnormal_nociception_after0.74916662
110MP0003699_abnormal_female_reproductive0.74799424
111MP0002234_abnormal_pharynx_morphology0.74650562
112MP0000013_abnormal_adipose_tissue0.73947198
113MP0005195_abnormal_posterior_eye0.73946509
114MP0009643_abnormal_urine_homeostasis0.73734529
115MP0009053_abnormal_anal_canal0.73732212
116MP0002752_abnormal_somatic_nervous0.71866734
117MP0003755_abnormal_palate_morphology0.71486846
118MP0005647_abnormal_sex_gland0.70667880
119MP0002078_abnormal_glucose_homeostasis0.69926160
120MP0010329_abnormal_lipoprotein_level0.69493665
121MP0004145_abnormal_muscle_electrophysio0.68844288
122MP0001666_abnormal_nutrient_absorption0.67883514
123MP0003953_abnormal_hormone_level0.67198558
124MP0008875_abnormal_xenobiotic_pharmacok0.66831920
125MP0003186_abnormal_redox_activity0.66730564
126MP0002064_seizures0.66539824
127MP0003937_abnormal_limbs/digits/tail_de0.66208384
128MP0002572_abnormal_emotion/affect_behav0.64927407
129MP0003635_abnormal_synaptic_transmissio0.64144933
130MP0010030_abnormal_orbit_morphology0.63735251
131MP0002063_abnormal_learning/memory/cond0.63431543
132MP0000613_abnormal_salivary_gland0.62596789
133MP0003315_abnormal_perineum_morphology0.62307155
134MP0000049_abnormal_middle_ear0.61220244
135MP0010368_abnormal_lymphatic_system0.60226518
136MP0000639_abnormal_adrenal_gland0.59902762
137MP0002136_abnormal_kidney_physiology0.59516780
138MP0000778_abnormal_nervous_system0.57928570
139MP0002116_abnormal_craniofacial_bone0.57457458
140MP0002837_dystrophic_cardiac_calcinosis0.56605305
141MP0003329_amyloid_beta_deposits0.56573429
142MP0002909_abnormal_adrenal_gland0.55672265
143MP0002067_abnormal_sensory_capabilities0.54464476
144MP0002882_abnormal_neuron_morphology0.54206895
145MP0000653_abnormal_sex_gland0.54173514
146MP0002734_abnormal_mechanical_nocicepti0.53677389
147MP0003252_abnormal_bile_duct0.53299596
148MP0002928_abnormal_bile_duct0.53091904
149MP0009780_abnormal_chondrocyte_physiolo0.51813850
150MP0005645_abnormal_hypothalamus_physiol0.51325858
151MP0010678_abnormal_skin_adnexa0.51280173
152MP0004264_abnormal_extraembryonic_tissu0.51084257
153MP0001968_abnormal_touch/_nociception0.50728335
154MP0005197_abnormal_uvea_morphology0.50645488
155MP0001286_abnormal_eye_development0.50549781
156MP0001340_abnormal_eyelid_morphology0.50272169
157MP0003115_abnormal_respiratory_system0.49443281
158MP0004484_altered_response_of0.48753380
159MP0003880_abnormal_central_pattern0.48439433
160MP0002229_neurodegeneration0.47969840
161MP0003119_abnormal_digestive_system0.46901360
162MP0002115_abnormal_skeleton_extremities0.45665790
163MP0003861_abnormal_nervous_system0.45317213
164MP0003787_abnormal_imprinting0.45232409
165MP0002177_abnormal_outer_ear0.44967461
166MP0000462_abnormal_digestive_system0.44151672

Predicted human phenotypes

RankGene SetZ-score
1Abnormal auditory evoked potentials (HP:0006958)7.41100041
2Tetany (HP:0001281)5.28386860
3Congenital stationary night blindness (HP:0007642)5.12627659
4Hypomagnesemia (HP:0002917)5.03852877
5Abnormal drinking behavior (HP:0030082)4.57350384
6Polydipsia (HP:0001959)4.57350384
7Hyperuricemia (HP:0002149)4.45186701
8Increased purine levels (HP:0004368)4.45186701
9Polyuria (HP:0000103)4.25797293
10Congenital sensorineural hearing impairment (HP:0008527)4.24949790
11Hypoglycemic coma (HP:0001325)4.16913139
12Decreased central vision (HP:0007663)4.09896922
13Multiple enchondromatosis (HP:0005701)3.92195092
14Abnormal urine output (HP:0012590)3.90560311
15Arterial tortuosity (HP:0005116)3.90135350
16Generalized aminoaciduria (HP:0002909)3.82321035
17Shawl scrotum (HP:0000049)3.70942782
18Pancreatic cysts (HP:0001737)3.69688299
19Abnormality of magnesium homeostasis (HP:0004921)3.66749769
20Abnormality of renal excretion (HP:0011036)3.66673040
21Metabolic alkalosis (HP:0200114)3.65697925
22True hermaphroditism (HP:0010459)3.48977692
23Hypothermia (HP:0002045)3.47669045
24Male infertility (HP:0003251)3.39710057
25Febrile seizures (HP:0002373)3.39327213
26Vascular tortuosity (HP:0004948)3.37795504
27Abnormality of purine metabolism (HP:0004352)3.36705760
28Increased circulating renin level (HP:0000848)3.31168991
29Bicornuate uterus (HP:0000813)3.24893355
30Hepatic necrosis (HP:0002605)3.24323660
31Pancreatic fibrosis (HP:0100732)3.22365624
32Gout (HP:0001997)3.21700931
33Renal tubular acidosis (HP:0001947)3.07805492
34Medial flaring of the eyebrow (HP:0010747)3.03614466
35Exostoses (HP:0100777)3.03115748
36Abnormality of the renal cortex (HP:0011035)3.00160140
37Hypokalemic alkalosis (HP:0001949)2.99057618
38Papillary thyroid carcinoma (HP:0002895)2.93063840
39Proximal tubulopathy (HP:0000114)2.86749070
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.86254074
41Hypoplasia of the fovea (HP:0007750)2.86254074
42Abnormality of aromatic amino acid family metabolism (HP:0004338)2.79158996
43Gaze-evoked nystagmus (HP:0000640)2.77990949
44Aplasia/Hypoplasia of the macula (HP:0008059)2.77879041
45Lymphangioma (HP:0100764)2.76924282
46Hyperaldosteronism (HP:0000859)2.76526679
47Lower limb asymmetry (HP:0100559)2.73202406
48Aplasia involving bones of the extremities (HP:0009825)2.73117360
49Aplasia involving bones of the upper limbs (HP:0009823)2.73117360
50Aplasia of the phalanges of the hand (HP:0009802)2.73117360
51Oligodactyly (hands) (HP:0001180)2.72522637
52Hypercalciuria (HP:0002150)2.70622813
53Abnormality of chloride homeostasis (HP:0011422)2.70111450
54Midline defect of the nose (HP:0004122)2.69515899
55Abnormality of the parathyroid morphology (HP:0011766)2.69342609
56Hyperactive renin-angiotensin system (HP:0000841)2.65999342
57Type I diabetes mellitus (HP:0100651)2.65349819
58Hyperinsulinemic hypoglycemia (HP:0000825)2.63822764
59Lip pit (HP:0100267)2.60196327
60Hepatocellular necrosis (HP:0001404)2.59133539
61Aplasia/Hypoplasia affecting the retina (HP:0008061)2.58404018
62Nephrogenic diabetes insipidus (HP:0009806)2.58160969
63Potter facies (HP:0002009)2.57223357
64Facial shape deformation (HP:0011334)2.57223357
65Renal cortical cysts (HP:0000803)2.56618104
66Renal salt wasting (HP:0000127)2.55271549
67Sensory axonal neuropathy (HP:0003390)2.53421516
68Ocular albinism (HP:0001107)2.52032052
69Abnormal biliary tract physiology (HP:0012439)2.51826315
70Bile duct proliferation (HP:0001408)2.51826315
71Gait imbalance (HP:0002141)2.51514500
72Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51477246
73Abnormality of macular pigmentation (HP:0008002)2.51404535
74Facial hemangioma (HP:0000329)2.50366019
75Furrowed tongue (HP:0000221)2.48923790
76Congenital primary aphakia (HP:0007707)2.46640539
77Abnormality of midbrain morphology (HP:0002418)2.46575830
78Molar tooth sign on MRI (HP:0002419)2.46575830
79Chronic hepatic failure (HP:0100626)2.43584174
80Hyperventilation (HP:0002883)2.42769769
81Vitreoretinal degeneration (HP:0000655)2.42203188
82Epiphyseal dysplasia (HP:0002656)2.42040279
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.40176954
84Iris hypopigmentation (HP:0007730)2.39156769
85Attenuation of retinal blood vessels (HP:0007843)2.38815880
86Choroideremia (HP:0001139)2.38522477
87Abnormality of the fovea (HP:0000493)2.36264213
88Intestinal atresia (HP:0011100)2.36253879
89Abnormal hair whorl (HP:0010721)2.35937543
90Progressive macrocephaly (HP:0004481)2.35713263
91Patchy hypopigmentation of hair (HP:0011365)2.35296380
92Large for gestational age (HP:0001520)2.33661120
93Azoospermia (HP:0000027)2.33072233
94Cystic liver disease (HP:0006706)2.31522118
95Blue irides (HP:0000635)2.30997447
96Glycosuria (HP:0003076)2.29208887
97Abnormality of urine glucose concentration (HP:0011016)2.29208887
98Spondylolisthesis (HP:0003302)2.28801949
99Chin dimple (HP:0010751)2.28783394
100Nephronophthisis (HP:0000090)2.28502820
101Ketosis (HP:0001946)2.28446672
102Oligodactyly (HP:0012165)2.28230851
103Hypoglycemic seizures (HP:0002173)2.25046780
104Abnormal pancreas size (HP:0012094)2.22277747
105Type II lissencephaly (HP:0007260)2.21993985
106Tubulointerstitial fibrosis (HP:0005576)2.20775639
107Severe Myopia (HP:0011003)2.19584756
108Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.16749138
109Sex reversal (HP:0012245)2.16302664
110Abnormal sex determination (HP:0012244)2.16302664
111Acute necrotizing encephalopathy (HP:0006965)2.15959826
112Sclerocornea (HP:0000647)2.15805371
113Delayed epiphyseal ossification (HP:0002663)2.13300303
114Disproportionate short-trunk short stature (HP:0003521)2.13024319
115Confusion (HP:0001289)2.12412189
116Progressive inability to walk (HP:0002505)2.12402356
117Type I transferrin isoform profile (HP:0003642)2.09496434
118Abnormality of the fingertips (HP:0001211)2.09460793
119Acute encephalopathy (HP:0006846)2.08954516
120Hydroxyprolinuria (HP:0003080)2.08562743
121Abnormality of proline metabolism (HP:0010907)2.08562743
122Abnormal rod and cone electroretinograms (HP:0008323)2.08463098
123Fibular aplasia (HP:0002990)2.07899982
124Abnormality of nucleobase metabolism (HP:0010932)2.07504432
125Abnormality of the renal medulla (HP:0100957)2.07054404
126Camptodactyly of toe (HP:0001836)2.06960181
127Enlarged epiphyses (HP:0010580)2.05982261
128Morphological abnormality of the inner ear (HP:0011390)2.04319715
129Abnormal cartilage morphology (HP:0002763)2.03905079
130Increased CSF lactate (HP:0002490)2.02849229
131Mitochondrial inheritance (HP:0001427)2.01244696
132Generalized hypopigmentation of hair (HP:0011358)2.00063458
133Abnormality of cochlea (HP:0000375)1.99819906
134Tubular atrophy (HP:0000092)1.97979812
135Nephrocalcinosis (HP:0000121)1.96623297
136Hypokinesia (HP:0002375)1.94516249
137Diminished movement (HP:0002374)1.94340609
138Dyskinesia (HP:0100660)1.93073728
139Amblyopia (HP:0000646)1.92851400
140Albinism (HP:0001022)1.92615716
141Genital tract atresia (HP:0001827)1.91818126
142Abnormal albumin level (HP:0012116)1.90683834
143Hypoalbuminemia (HP:0003073)1.90683834
144Thyroid carcinoma (HP:0002890)1.87926452
145Occipital encephalocele (HP:0002085)1.87885718
146Generalized hypopigmentation (HP:0007513)1.87782654
147Abnormality of the pubic bones (HP:0003172)1.86893043
148Abnormality of liposaccharide metabolism (HP:0010968)1.86452519
149Abnormality of glycosphingolipid metabolism (HP:0004343)1.86452519
150Abnormality of glycolipid metabolism (HP:0010969)1.86452519
151Fair hair (HP:0002286)1.86041395
152Mixed hearing impairment (HP:0000410)1.85039678
153Patellar aplasia (HP:0006443)1.82504890
154Male pseudohermaphroditism (HP:0000037)1.82304939
155Apathy (HP:0000741)1.81806722
156White forelock (HP:0002211)1.81759990
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.81660910
158Severe visual impairment (HP:0001141)1.81659341
159Neuroendocrine neoplasm (HP:0100634)1.80810800
160Arachnodactyly (HP:0001166)1.80738968
161EEG with generalized epileptiform discharges (HP:0011198)1.80714165
162Hyperglycemia (HP:0003074)1.80024912
163Vaginal atresia (HP:0000148)1.79413483
164Aplasia/hypoplasia of the uterus (HP:0008684)1.79245029
165Epileptiform EEG discharges (HP:0011182)1.78676411
166Exocrine pancreatic insufficiency (HP:0001738)1.78416164
167Stomach cancer (HP:0012126)1.74884944
168Hypophosphatemic rickets (HP:0004912)1.74720423
169Abnormal mitochondria in muscle tissue (HP:0008316)1.72604110
170Neonatal respiratory distress (HP:0002643)1.71899678
171Hip contracture (HP:0003273)1.71846756
172Abnormality of renin-angiotensin system (HP:0000847)1.71833280
173Steatorrhea (HP:0002570)1.71305903
174Hypsarrhythmia (HP:0002521)1.71282419
175Horizontal nystagmus (HP:0000666)1.71254785
176Alkalosis (HP:0001948)1.67859663
177Morphological abnormality of the middle ear (HP:0008609)1.67271525
178Hyperphosphaturia (HP:0003109)1.64508065
179Synostosis of carpal bones (HP:0005048)1.64420647
180Epidermoid cyst (HP:0200040)1.63141259
181Sandal gap (HP:0001852)1.62880746
182Hemangiomatosis (HP:0007461)1.61971772
183Asymmetric growth (HP:0100555)1.61120480
184Diminished motivation (HP:0000745)1.58817517
185Metaphyseal dysplasia (HP:0100255)1.58315141
186Hepatoblastoma (HP:0002884)1.57857815
187Vacuolated lymphocytes (HP:0001922)1.57703365
188Aplasia/Hypoplasia of the patella (HP:0006498)1.57689448
189Exotropia (HP:0000577)1.56831118
190Focal motor seizures (HP:0011153)1.54642913
191Ketoacidosis (HP:0001993)1.54435364

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.38965724
2LATS14.32042556
3MAP3K93.31816838
4MST43.27931105
5KSR23.22105972
6STK38L3.10891538
7WNK42.92051281
8BMPR22.87344170
9MOS2.81947225
10LATS22.70532347
11INSRR2.56165359
12EEF2K2.55051037
13BCR2.52295444
14WNK32.43689170
15MAP3K132.40163712
16KSR12.36855918
17ERBB32.25381327
18EPHA42.25104807
19ACVR1B2.21788614
20PINK12.19628815
21RAF12.14704233
22TRPM72.10843174
23TRIM282.08240279
24ERBB42.03689831
25OXSR12.03409041
26ARAF1.93473969
27EPHA31.91067178
28GRK11.90922395
29RIPK41.73662417
30SIK31.72203264
31DDR21.71165002
32CASK1.66970170
33MAP3K61.66039863
34BRAF1.62840164
35EPHA21.62156214
36TAOK31.56334535
37MAP3K31.53470458
38EIF2AK31.48291943
39MAP3K121.44109362
40PRKD31.43780521
41MAP4K21.42473377
42ADRBK21.42169218
43PLK21.41613337
44MUSK1.39773387
45NME11.39116381
46NUAK11.39033057
47PIK3CG1.37916508
48MAPK131.27163578
49MELK1.25180839
50STK381.25009739
51DMPK1.23441846
52STK241.18731559
53PAK61.15292974
54MYLK1.14355063
55PAK31.12904782
56DYRK21.11510424
57TTK1.08949219
58STK391.05097009
59NEK61.04540384
60STK30.99606534
61PLK40.97476699
62FER0.95762027
63NTRK10.95063986
64SGK20.94941360
65NTRK30.92703197
66MAP3K40.92374619
67TGFBR10.92341621
68CDC70.88252816
69RET0.88060511
70SGK2230.87607289
71SGK4940.87607289
72FGFR20.86911313
73HIPK20.85966144
74PTK2B0.85643956
75LIMK10.84059619
76STK100.78217139
77EPHB10.77333636
78MAPKAPK50.77100940
79FGR0.76963671
80CDK90.75634549
81PRKCG0.70801617
82TAOK10.69076653
83MET0.69070581
84CSNK1G20.68959058
85ADRBK10.68093464
86PASK0.67130805
87MARK30.65553792
88CSNK1G30.65192018
89CSNK1G10.60757995
90EPHB20.60528305
91PRKD20.60152965
92TNK20.59567985
93PRKCE0.58743275
94CAMK2A0.58075790
95ROCK10.57558633
96MAPKAPK30.57537060
97TEC0.56284432
98PHKG10.56122947
99PHKG20.56122947
100CSNK1A1L0.55654158
101CDK80.55405796
102MINK10.54520058
103MAP2K40.53623878
104SGK30.52924040
105MAP3K20.52804985
106CAMKK20.52613145
107PKN10.52492219
108PRKCI0.47130395
109TXK0.46604365
110FLT30.45352141
111TYRO30.45011278
112MAPK150.44373521
113DYRK1A0.43686766
114CDK50.42559695
115NLK0.42442570
116MAPK110.42386544
117SGK10.41789629
118MAP3K10.41335958
119NEK90.40953666
120MAP2K10.40248954
121PRKAA20.39413344
122BMPR1B0.39391589
123MAP2K60.38703280
124MST1R0.38558610
125MKNK20.38025208
126ERBB20.37722191
127PRKCZ0.37571190
128PRKCH0.37182597
129STK110.36736545
130ROCK20.35009169
131TNIK0.34834588
132MAP3K80.34741927
133IRAK10.34484873
134PTK20.34420730
135PRKACA0.34056864
136CSNK1D0.33061580
137CDK60.32291774
138BRSK20.32283765
139WNK10.31168472
140MAP2K70.30799398
141AKT20.30627431
142DAPK20.30359278
143ABL20.29868666
144EGFR0.28597206
145NEK10.28191624
146PRKCQ0.27982115
147IKBKB0.27725437
148RPS6KB20.27194171
149PRKAA10.26743163
150PRKG20.26729437

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049133.29794317
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.93940541
3Protein export_Homo sapiens_hsa030602.67665574
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.61654743
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.57277658
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.32840362
7Steroid hormone biosynthesis_Homo sapiens_hsa001402.12945372
8Nitrogen metabolism_Homo sapiens_hsa009102.05455799
9Phototransduction_Homo sapiens_hsa047441.95462553
10Dorso-ventral axis formation_Homo sapiens_hsa043201.95317267
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.95013483
12Long-term potentiation_Homo sapiens_hsa047201.89930135
13Tryptophan metabolism_Homo sapiens_hsa003801.89778085
14Retinol metabolism_Homo sapiens_hsa008301.87572299
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.82326552
16Butanoate metabolism_Homo sapiens_hsa006501.81564987
17Oxidative phosphorylation_Homo sapiens_hsa001901.61912558
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61189664
19Choline metabolism in cancer_Homo sapiens_hsa052311.60413069
20GnRH signaling pathway_Homo sapiens_hsa049121.59442561
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.59199685
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58866813
23Pancreatic cancer_Homo sapiens_hsa052121.57697255
24Basal transcription factors_Homo sapiens_hsa030221.55858673
25Long-term depression_Homo sapiens_hsa047301.54592243
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.51146810
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51125949
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49840191
29Sphingolipid metabolism_Homo sapiens_hsa006001.49394381
30Chemical carcinogenesis_Homo sapiens_hsa052041.47226467
31TGF-beta signaling pathway_Homo sapiens_hsa043501.47162783
32Nicotine addiction_Homo sapiens_hsa050331.43556095
33Tight junction_Homo sapiens_hsa045301.42774493
34Oocyte meiosis_Homo sapiens_hsa041141.42256279
35Glutamatergic synapse_Homo sapiens_hsa047241.38343827
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32781387
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.31615262
38Peroxisome_Homo sapiens_hsa041461.31250890
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28879157
40Circadian rhythm_Homo sapiens_hsa047101.28366741
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26483462
42VEGF signaling pathway_Homo sapiens_hsa043701.22802145
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22623674
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.21434632
45Amphetamine addiction_Homo sapiens_hsa050311.18070302
46Thyroid hormone synthesis_Homo sapiens_hsa049181.17923777
47FoxO signaling pathway_Homo sapiens_hsa040681.14110220
48Linoleic acid metabolism_Homo sapiens_hsa005911.13538039
49Arginine and proline metabolism_Homo sapiens_hsa003301.13017327
50Caffeine metabolism_Homo sapiens_hsa002321.11818482
51Estrogen signaling pathway_Homo sapiens_hsa049151.11559293
52Endometrial cancer_Homo sapiens_hsa052131.06948179
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06499984
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05126973
55Hippo signaling pathway_Homo sapiens_hsa043901.03233671
56ABC transporters_Homo sapiens_hsa020101.02582308
57Selenocompound metabolism_Homo sapiens_hsa004501.02187855
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01860029
59Adherens junction_Homo sapiens_hsa045201.01793287
60Gastric acid secretion_Homo sapiens_hsa049710.99358295
61Collecting duct acid secretion_Homo sapiens_hsa049660.98664072
62Melanogenesis_Homo sapiens_hsa049160.98454665
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98444802
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97616621
65beta-Alanine metabolism_Homo sapiens_hsa004100.97055725
66ECM-receptor interaction_Homo sapiens_hsa045120.96920297
67Parkinsons disease_Homo sapiens_hsa050120.95937484
68Cell cycle_Homo sapiens_hsa041100.95250786
69ErbB signaling pathway_Homo sapiens_hsa040120.94436959
70Dopaminergic synapse_Homo sapiens_hsa047280.93100185
71Colorectal cancer_Homo sapiens_hsa052100.92803140
72Mineral absorption_Homo sapiens_hsa049780.92668681
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92516074
74Glioma_Homo sapiens_hsa052140.90865094
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90617026
76Starch and sucrose metabolism_Homo sapiens_hsa005000.90395875
77Protein digestion and absorption_Homo sapiens_hsa049740.90113111
78Prolactin signaling pathway_Homo sapiens_hsa049170.88534459
79Olfactory transduction_Homo sapiens_hsa047400.88088918
80Oxytocin signaling pathway_Homo sapiens_hsa049210.87883180
81GABAergic synapse_Homo sapiens_hsa047270.87108581
82Insulin secretion_Homo sapiens_hsa049110.85666722
83MicroRNAs in cancer_Homo sapiens_hsa052060.85289483
84Axon guidance_Homo sapiens_hsa043600.85081158
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84617419
86Histidine metabolism_Homo sapiens_hsa003400.83282673
87Fatty acid degradation_Homo sapiens_hsa000710.82984583
88cAMP signaling pathway_Homo sapiens_hsa040240.82477850
89Renal cell carcinoma_Homo sapiens_hsa052110.82012835
90Metabolic pathways_Homo sapiens_hsa011000.81564686
91Phenylalanine metabolism_Homo sapiens_hsa003600.81287014
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80550585
93Lysine degradation_Homo sapiens_hsa003100.80054806
94Bile secretion_Homo sapiens_hsa049760.79821645
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.78253685
96Gap junction_Homo sapiens_hsa045400.77979701
97Renin secretion_Homo sapiens_hsa049240.76701959
98Cocaine addiction_Homo sapiens_hsa050300.75687360
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74297312
100Huntingtons disease_Homo sapiens_hsa050160.72454889
101Thyroid cancer_Homo sapiens_hsa052160.72428195
102Wnt signaling pathway_Homo sapiens_hsa043100.71895970
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70803289
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.70619099
105Tyrosine metabolism_Homo sapiens_hsa003500.70558702
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69714386
107RNA degradation_Homo sapiens_hsa030180.69290203
108Ether lipid metabolism_Homo sapiens_hsa005650.69199770
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.68911388
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68739691
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68628088
112Morphine addiction_Homo sapiens_hsa050320.67908509
113Salivary secretion_Homo sapiens_hsa049700.67841803
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66543204
115Alzheimers disease_Homo sapiens_hsa050100.65730177
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65477492
117Serotonergic synapse_Homo sapiens_hsa047260.65393976
118Bladder cancer_Homo sapiens_hsa052190.65383314
119Regulation of autophagy_Homo sapiens_hsa041400.65326151
120Glutathione metabolism_Homo sapiens_hsa004800.64508747
121Hedgehog signaling pathway_Homo sapiens_hsa043400.64070062
122Propanoate metabolism_Homo sapiens_hsa006400.63699842
123Hepatitis C_Homo sapiens_hsa051600.62512681
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62363053
125Prostate cancer_Homo sapiens_hsa052150.61355027
126Non-small cell lung cancer_Homo sapiens_hsa052230.61243907
127Fatty acid metabolism_Homo sapiens_hsa012120.60996490
128Proteoglycans in cancer_Homo sapiens_hsa052050.60781339
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58965879
130African trypanosomiasis_Homo sapiens_hsa051430.58649412
131RNA polymerase_Homo sapiens_hsa030200.57991319
132Vitamin B6 metabolism_Homo sapiens_hsa007500.57845474
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57585948
134Focal adhesion_Homo sapiens_hsa045100.55742541
135Cholinergic synapse_Homo sapiens_hsa047250.55076914
136Chronic myeloid leukemia_Homo sapiens_hsa052200.55039700
137Glucagon signaling pathway_Homo sapiens_hsa049220.54946018
138Other glycan degradation_Homo sapiens_hsa005110.54794299
139Fatty acid biosynthesis_Homo sapiens_hsa000610.54691453
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54089004
141Inositol phosphate metabolism_Homo sapiens_hsa005620.53553251
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53294972
143Drug metabolism - other enzymes_Homo sapiens_hsa009830.53088200
144Circadian entrainment_Homo sapiens_hsa047130.52758158
145Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52585784
146Complement and coagulation cascades_Homo sapiens_hsa046100.52040186
147N-Glycan biosynthesis_Homo sapiens_hsa005100.51899988
148Glycerolipid metabolism_Homo sapiens_hsa005610.51309294
149Glycosaminoglycan degradation_Homo sapiens_hsa005310.50687248
150Synaptic vesicle cycle_Homo sapiens_hsa047210.50194860
151Steroid biosynthesis_Homo sapiens_hsa001000.49877063
152Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49610037
153Sulfur metabolism_Homo sapiens_hsa009200.48658308
154Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48141885
155Maturity onset diabetes of the young_Homo sapiens_hsa049500.47869555
156Type II diabetes mellitus_Homo sapiens_hsa049300.47364429
157Pancreatic secretion_Homo sapiens_hsa049720.45978751
158Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45780951
159Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45678271
160Taste transduction_Homo sapiens_hsa047420.45269409
161Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41493624
162Arginine biosynthesis_Homo sapiens_hsa002200.36620967
163Proteasome_Homo sapiens_hsa030500.35446969
164Fat digestion and absorption_Homo sapiens_hsa049750.35398480
165Cardiac muscle contraction_Homo sapiens_hsa042600.34491193
166SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33276614
167Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32546755
168Arachidonic acid metabolism_Homo sapiens_hsa005900.30093142
169Homologous recombination_Homo sapiens_hsa034400.29366627

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