ZRANB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal cone cell development (GO:0046549)4.26142986
2establishment of nucleus localization (GO:0040023)4.22612486
3photoreceptor cell development (GO:0042461)4.22134015
4photoreceptor cell maintenance (GO:0045494)4.21841830
5eye photoreceptor cell development (GO:0042462)4.08511958
6myofibril assembly (GO:0030239)4.06115378
7eye photoreceptor cell differentiation (GO:0001754)4.05145786
8photoreceptor cell differentiation (GO:0046530)4.05145786
9presynaptic membrane assembly (GO:0097105)3.93992048
10actin-myosin filament sliding (GO:0033275)3.89002398
11muscle filament sliding (GO:0030049)3.89002398
12regulation of rhodopsin mediated signaling pathway (GO:0022400)3.88123656
13rhodopsin mediated signaling pathway (GO:0016056)3.85033644
14retinal rod cell development (GO:0046548)3.84714622
15actin-mediated cell contraction (GO:0070252)3.59686396
16cellular response to epinephrine stimulus (GO:0071872)3.53612381
17nucleus localization (GO:0051647)3.51316692
18presynaptic membrane organization (GO:0097090)3.51110063
19negative regulation of type 2 immune response (GO:0002829)3.48433674
20cardiac muscle hypertrophy (GO:0003300)3.45820611
21regulation of protein polyubiquitination (GO:1902914)3.28338648
22striated muscle hypertrophy (GO:0014897)3.28139918
23neuronal action potential propagation (GO:0019227)3.28111159
24regulation of relaxation of muscle (GO:1901077)3.24781164
25detection of light stimulus involved in sensory perception (GO:0050962)3.24473372
26detection of light stimulus involved in visual perception (GO:0050908)3.24473372
27response to muscle activity (GO:0014850)3.20235422
28actin filament-based movement (GO:0030048)3.17990317
29response to epinephrine (GO:0071871)3.15595609
30interkinetic nuclear migration (GO:0022027)3.15398803
31retina layer formation (GO:0010842)3.15300756
32peptidyl-threonine phosphorylation (GO:0018107)2.99454427
33regulation of meiosis I (GO:0060631)2.99253443
34appendage development (GO:0048736)2.96057353
35limb development (GO:0060173)2.96057353
36protein targeting to Golgi (GO:0000042)2.92366505
37skeletal muscle adaptation (GO:0043501)2.91015491
38cardiac muscle hypertrophy in response to stress (GO:0014898)2.90853466
39muscle hypertrophy in response to stress (GO:0003299)2.90853466
40cardiac muscle adaptation (GO:0014887)2.90853466
41cardiac myofibril assembly (GO:0055003)2.89958843
42epithelial cell differentiation involved in kidney development (GO:0035850)2.89823970
43sarcomere organization (GO:0045214)2.89376216
44regulation of phosphoprotein phosphatase activity (GO:0043666)2.88558987
45peptidyl-threonine modification (GO:0018210)2.86641106
46visual perception (GO:0007601)2.86432054
47sensory perception of light stimulus (GO:0050953)2.84642728
48postsynaptic membrane organization (GO:0001941)2.84006214
49retrograde transport, vesicle recycling within Golgi (GO:0000301)2.83190207
50positive regulation of meiosis (GO:0045836)2.82513026
51striated muscle adaptation (GO:0014888)2.81823643
52skeletal muscle contraction (GO:0003009)2.81567399
53negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.80821566
54negative regulation of translation, ncRNA-mediated (GO:0040033)2.80821566
55regulation of translation, ncRNA-mediated (GO:0045974)2.80821566
56muscle hypertrophy (GO:0014896)2.79875332
57positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.79125729
58histone lysine demethylation (GO:0070076)2.79018445
59phototransduction (GO:0007602)2.78847006
60negative regulation of norepinephrine secretion (GO:0010700)2.77420460
61G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.76056042
62neuron remodeling (GO:0016322)2.75979754
63detection of light stimulus (GO:0009583)2.71821081
64positive regulation of meiotic cell cycle (GO:0051446)2.70207189
65G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.67957327
66negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.67155941
67positive regulation of microtubule polymerization (GO:0031116)2.66657471
68positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.66252290
69detection of visible light (GO:0009584)2.65004254
70protein-chromophore linkage (GO:0018298)2.64282393
71histone H3-K9 demethylation (GO:0033169)2.63841011
72protein dealkylation (GO:0008214)2.62572498
73protein demethylation (GO:0006482)2.62572498
74response to inactivity (GO:0014854)2.60843576
75negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.60343000
76phototransduction, visible light (GO:0007603)2.60208466
77regulation of RNA export from nucleus (GO:0046831)2.60004138
78positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.59845603
79negative regulation of fibroblast apoptotic process (GO:2000270)2.59602337
80histone H3-K36 demethylation (GO:0070544)2.57222472
81regulation of skeletal muscle contraction (GO:0014819)2.57205122
82insulin-like growth factor receptor signaling pathway (GO:0048009)2.57178268
83regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.56222093
84embryonic retina morphogenesis in camera-type eye (GO:0060059)2.55773099
85negative regulation of hormone biosynthetic process (GO:0032353)2.55331468
86negative regulation of hormone metabolic process (GO:0032351)2.55331468
87positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.54158874
88regulation of myoblast differentiation (GO:0045661)2.53732681
89myoblast fusion (GO:0007520)2.53096671
90histone demethylation (GO:0016577)2.51975398
91anatomical structure arrangement (GO:0048532)2.51330474
92positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.50857690
93dicarboxylic acid biosynthetic process (GO:0043650)2.50615906
94plasma membrane repair (GO:0001778)2.50256963
95chemical homeostasis within a tissue (GO:0048875)2.50184187
96regulation of nucleobase-containing compound transport (GO:0032239)2.49810038
97positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.49726937
98positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.46676523
99regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.46676523
100nuclear pore complex assembly (GO:0051292)2.46594585
101negative regulation of Rho protein signal transduction (GO:0035024)2.46462455
102cerebral cortex radially oriented cell migration (GO:0021799)2.45854426
103striated muscle contraction (GO:0006941)2.45255661
104neurotransmitter-gated ion channel clustering (GO:0072578)2.45224356
105negative regulation of cAMP-mediated signaling (GO:0043951)2.45198251
106TOR signaling (GO:0031929)2.44576218
107retina development in camera-type eye (GO:0060041)2.42763370
108cerebellar Purkinje cell differentiation (GO:0021702)2.42207396
109actomyosin structure organization (GO:0031032)2.41638795
110DNA methylation involved in gamete generation (GO:0043046)2.41505320
111surfactant homeostasis (GO:0043129)2.41286061
112protein localization to cilium (GO:0061512)2.41222249
113regulation of fibroblast apoptotic process (GO:2000269)2.40270390
114piRNA metabolic process (GO:0034587)2.38988146
115sarcoplasmic reticulum calcium ion transport (GO:0070296)2.38479383
116adaptation of signaling pathway (GO:0023058)2.38454935
117regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.38350918
118establishment of protein localization to Golgi (GO:0072600)2.37915960
119striated muscle atrophy (GO:0014891)2.37817043
120protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.37728013
121protein localization to synapse (GO:0035418)2.37474371
122dentate gyrus development (GO:0021542)2.36272223
123adult heart development (GO:0007512)2.36151447
124phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.35546598
125intraciliary transport (GO:0042073)2.35471513
126limb bud formation (GO:0060174)2.33790139
127histone H3-K4 trimethylation (GO:0080182)2.33771263
128cellular response to monoamine stimulus (GO:0071868)2.32324928
129cellular response to catecholamine stimulus (GO:0071870)2.32324928
130regulation of necroptotic process (GO:0060544)2.32172371
131regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.31857053
132cytoplasmic mRNA processing body assembly (GO:0033962)2.30596113
133regulation of histone H3-K27 methylation (GO:0061085)2.30459262
134peptidyl-serine phosphorylation (GO:0018105)2.29669627
135response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.29310626
136vesicle transport along microtubule (GO:0047496)2.27431938
137glutamate receptor signaling pathway (GO:0007215)2.26933858
138syncytium formation by plasma membrane fusion (GO:0000768)2.26701083
139regulation of p38MAPK cascade (GO:1900744)2.26538405
140regulation of skeletal muscle fiber development (GO:0048742)2.26041328
141righting reflex (GO:0060013)2.25737842
142cell differentiation involved in kidney development (GO:0061005)2.25692981
143central nervous system projection neuron axonogenesis (GO:0021952)2.25248648
144regulation of NFAT protein import into nucleus (GO:0051532)2.25131371
145cytoskeletal anchoring at plasma membrane (GO:0007016)2.24968939
146muscle contraction (GO:0006936)2.24799380
147macroautophagy (GO:0016236)2.24369628
148regulation of phospholipid biosynthetic process (GO:0071071)2.24183774
149coronary vasculature morphogenesis (GO:0060977)2.23650558
150cellular response to osmotic stress (GO:0071470)2.23120737
151genitalia morphogenesis (GO:0035112)2.23098418
152negative regulation of catecholamine secretion (GO:0033604)2.22814889
153muscle adaptation (GO:0043500)2.21706897
154regulation of isotype switching to IgG isotypes (GO:0048302)2.21162499
155regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.21124691
156positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.21124691
157regulation of Rac protein signal transduction (GO:0035020)2.20756678
158spinal cord motor neuron differentiation (GO:0021522)2.20521650
159negative regulation of receptor-mediated endocytosis (GO:0048261)2.20434181
160dendrite morphogenesis (GO:0048813)2.19710068
161carnitine shuttle (GO:0006853)2.19681001
162calcium ion import (GO:0070509)2.19135289
163regulation of cAMP-dependent protein kinase activity (GO:2000479)2.19044811
164regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.18877625
165positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.18709089
166regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.18399840
167negative regulation of neurotransmitter secretion (GO:0046929)2.18394718
168nerve growth factor signaling pathway (GO:0038180)2.18077647
169lipid translocation (GO:0034204)2.17979902
170phospholipid translocation (GO:0045332)2.17979902
171response to monoamine (GO:0071867)2.17756288
172response to catecholamine (GO:0071869)2.17756288
173relaxation of cardiac muscle (GO:0055119)2.17746525
174negative regulation of inclusion body assembly (GO:0090084)2.17495591
175cranial nerve morphogenesis (GO:0021602)2.16658841
176cerebellar granule cell differentiation (GO:0021707)2.16322651
177chemosensory behavior (GO:0007635)2.15943818
178regulation of ARF protein signal transduction (GO:0032012)2.15823581
179startle response (GO:0001964)2.15551041
180central nervous system neuron axonogenesis (GO:0021955)2.15110731
181negative regulation of potassium ion transmembrane transport (GO:1901380)2.14631205
182neuronal stem cell maintenance (GO:0097150)2.13547751
183regulation of energy homeostasis (GO:2000505)2.13070318
184muscle system process (GO:0003012)2.12732947
185myotube differentiation (GO:0014902)2.12520701
186monoubiquitinated protein deubiquitination (GO:0035520)2.11103723
187fibroblast migration (GO:0010761)2.10858024

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.51665071
2GBX2_23144817_ChIP-Seq_PC3_Human3.02897348
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.65016241
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.41985600
5* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.35869339
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31128538
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.18984624
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.17072944
9TAF15_26573619_Chip-Seq_HEK293_Human1.99671879
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93142827
11FUS_26573619_Chip-Seq_HEK293_Human1.92207375
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.91119402
13BP1_19119308_ChIP-ChIP_Hs578T_Human1.89686208
14PIAS1_25552417_ChIP-Seq_VCAP_Human1.86898314
15GATA1_22025678_ChIP-Seq_K562_Human1.85407434
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.83996035
17PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83766891
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82990318
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81308426
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81124982
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76449433
22P300_19829295_ChIP-Seq_ESCs_Human1.72816620
23* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72544605
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72470081
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70374067
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69763353
27SMAD4_21799915_ChIP-Seq_A2780_Human1.67942961
28ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.63980905
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62455031
30IGF1R_20145208_ChIP-Seq_DFB_Human1.61521577
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.61038788
32ER_23166858_ChIP-Seq_MCF-7_Human1.56023766
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55897437
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55897437
35ZNF274_21170338_ChIP-Seq_K562_Hela1.54613676
36CTNNB1_20460455_ChIP-Seq_HCT116_Human1.51971756
37AR_21572438_ChIP-Seq_LNCaP_Human1.51554790
38* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50715972
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.50497712
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49195208
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.48813617
42BCAT_22108803_ChIP-Seq_LS180_Human1.48391386
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47651109
44STAT3_23295773_ChIP-Seq_U87_Human1.47408364
45RNF2_27304074_Chip-Seq_NSC_Mouse1.46841778
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46691510
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45566398
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45556313
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.44357823
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42153825
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.41071847
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39842867
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39274386
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38202101
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.37884182
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37674523
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36902210
58AHR_22903824_ChIP-Seq_MCF-7_Human1.36740563
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35806966
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35712822
61STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35705392
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.34667013
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34361052
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.34228053
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34182107
66TCF4_23295773_ChIP-Seq_U87_Human1.33290491
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33067305
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32574464
69EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32022517
70RUNX_20019798_ChIP-Seq_JUKART_Human1.31991910
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31432924
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.29969527
73RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29747390
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29747390
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.29125488
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.28277069
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28164372
78TP53_16413492_ChIP-PET_HCT116_Human1.27873223
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.27669387
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27307123
81SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.25958101
82EWS_26573619_Chip-Seq_HEK293_Human1.25835206
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24122256
84RXR_22108803_ChIP-Seq_LS180_Human1.21747669
85IRF1_19129219_ChIP-ChIP_H3396_Human1.21410443
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.21258053
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21242581
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20724504
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.20193588
90VDR_22108803_ChIP-Seq_LS180_Human1.20180582
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20076531
92* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19963068
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19166560
94SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18709063
95P53_22387025_ChIP-Seq_ESCs_Mouse1.18304488
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.17693621
97* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17501839
98RUNX2_22187159_ChIP-Seq_PCA_Human1.16595445
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16294676
100SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16248930
101EP300_21415370_ChIP-Seq_HL-1_Mouse1.16084443
102VDR_24787735_ChIP-Seq_THP-1_Human1.15980817
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15220627
104MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15055801
105ESR1_20079471_ChIP-ChIP_T-47D_Human1.14694182
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14456113
107STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14236328
108AR_25329375_ChIP-Seq_VCAP_Human1.14176233
109DROSHA_22980978_ChIP-Seq_HELA_Human1.14012517
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13718633
111SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13350504
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11530151
113NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11530151
114TAL1_26923725_Chip-Seq_HPCs_Mouse1.10651996
115JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10600161
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09665008
117YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09550641
118EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09343094
119FOXA2_19822575_ChIP-Seq_HepG2_Human1.08939852
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08543068
121SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08134552
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07581874
123TCF4_18268006_ChIP-ChIP_LS174T_Human1.07481133
124P300_18555785_Chip-Seq_ESCs_Mouse1.07304503
125FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06775246
126WT1_19549856_ChIP-ChIP_CCG9911_Human1.06515478
127GF1_26923725_Chip-Seq_HPCs_Mouse1.06429676
128HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06057809
129SOX2_21211035_ChIP-Seq_LN229_Gbm1.05901306
130SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04522458
131PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03631550
132WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03227255
133SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01715349
134CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01548187
135CJUN_26792858_Chip-Seq_BT549_Human1.00498045
136STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00025893
137TBX20_22328084_ChIP-Seq_HEART_Mouse0.98634972
138TBX20_22080862_ChIP-Seq_HEART_Mouse0.98634972
139TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98046777
140AR_19668381_ChIP-Seq_PC3_Human0.96570266
141TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96525604
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95394325
143SMAD3_21741376_ChIP-Seq_HESCs_Human0.95172297
144LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94886787
145BRD4_25478319_ChIP-Seq_HGPS_Human0.94880189
146IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94161223
147CBP_20019798_ChIP-Seq_JUKART_Human0.94161223
148NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94007438
149TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93224745
150BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93184821
151SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92783380
152FLI1_21867929_ChIP-Seq_TH2_Mouse0.92741778
153TP63_23658742_ChIP-Seq_EP156T_Human0.91742406
154CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90832161
155* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90811717
156* TBL1_22424771_ChIP-Seq_293T_Human0.90661961

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio4.31495113
2MP0005551_abnormal_eye_electrophysiolog4.07993752
3MP0000749_muscle_degeneration3.85799997
4MP0006072_abnormal_retinal_apoptosis3.54420210
5MP0003646_muscle_fatigue3.40737452
6MP0004130_abnormal_muscle_cell3.34068011
7MP0000569_abnormal_digit_pigmentation3.20564108
8MP0006292_abnormal_olfactory_placode3.05237560
9MP0005451_abnormal_body_composition3.00695038
10MP0001188_hyperpigmentation2.97511291
11MP0004084_abnormal_cardiac_muscle2.87544925
12MP0005253_abnormal_eye_physiology2.79981241
13MP0005409_darkened_coat_color2.65968143
14MP0002269_muscular_atrophy2.65236429
15MP0004087_abnormal_muscle_fiber2.62363853
16MP0000751_myopathy2.58025777
17MP0003011_delayed_dark_adaptation2.50772579
18MP0004270_analgesia2.48258016
19MP0004510_myositis2.44929417
20MP0002009_preneoplasia2.41520995
21MP0008057_abnormal_DNA_replication2.40455357
22MP0000759_abnormal_skeletal_muscle2.40402668
23MP0003880_abnormal_central_pattern2.29617591
24MP0009379_abnormal_foot_pigmentation2.29599932
25MP0002139_abnormal_hepatobiliary_system2.28562084
26MP0002106_abnormal_muscle_physiology2.18071755
27MP0000747_muscle_weakness2.12842772
28MP0003136_yellow_coat_color2.11666276
29MP0004233_abnormal_muscle_weight2.08662950
30MP0005369_muscle_phenotype2.01566968
31MP0002108_abnormal_muscle_morphology2.00174843
32MP0004484_altered_response_of2.00031074
33MP0005195_abnormal_posterior_eye1.98227943
34MP0001502_abnormal_circadian_rhythm1.95216964
35MP0000733_abnormal_muscle_development1.93873758
36MP0001984_abnormal_olfaction1.92528893
37MP0002971_abnormal_brown_adipose1.88783014
38MP0003828_pulmonary_edema1.79767948
39MP0003656_abnormal_erythrocyte_physiolo1.76243581
40MP0003787_abnormal_imprinting1.74058178
41MP0005248_abnormal_Harderian_gland1.71464442
42MP0003705_abnormal_hypodermis_morpholog1.70597944
43MP0002127_abnormal_cardiovascular_syste1.67480476
44MP0001486_abnormal_startle_reflex1.66391704
45MP0003091_abnormal_cell_migration1.64574810
46MP0004885_abnormal_endolymph1.63309798
47MP0000778_abnormal_nervous_system1.62800546
48MP0001324_abnormal_eye_pigmentation1.62278100
49MP0004859_abnormal_synaptic_plasticity1.56942009
50MP0005391_vision/eye_phenotype1.56613739
51MP0010630_abnormal_cardiac_muscle1.55430888
52MP0001346_abnormal_lacrimal_gland1.51457280
53MP0000631_abnormal_neuroendocrine_gland1.49672978
54MP0000750_abnormal_muscle_regeneration1.45873343
55MP0004782_abnormal_surfactant_physiolog1.45572828
56MP0005076_abnormal_cell_differentiation1.42676913
57MP0002229_neurodegeneration1.41039078
58MP0005330_cardiomyopathy1.38615291
59MP0005423_abnormal_somatic_nervous1.38463487
60MP0004185_abnormal_adipocyte_glucose1.37877037
61MP0002133_abnormal_respiratory_system1.36905674
62MP0005388_respiratory_system_phenotype1.36905674
63MP0010368_abnormal_lymphatic_system1.36808700
64MP0001440_abnormal_grooming_behavior1.35098015
65MP0002752_abnormal_somatic_nervous1.34438156
66MP0002638_abnormal_pupillary_reflex1.30989985
67MP0002972_abnormal_cardiac_muscle1.29915950
68MP0001851_eye_inflammation1.28837811
69MP0003950_abnormal_plasma_membrane1.28406289
70MP0005367_renal/urinary_system_phenotyp1.28276555
71MP0000516_abnormal_urinary_system1.28276555
72MP0000566_synostosis1.27063540
73MP0008004_abnormal_stomach_pH1.26214875
74MP0005275_abnormal_skin_tensile1.23754021
75MP0005410_abnormal_fertilization1.23047420
76MP0009780_abnormal_chondrocyte_physiolo1.21462712
77MP0003868_abnormal_feces_composition1.19018389
78MP0003221_abnormal_cardiomyocyte_apopto1.18922339
79MP0003453_abnormal_keratinocyte_physiol1.18184744
80MP0002557_abnormal_social/conspecific_i1.17320037
81MP0003941_abnormal_skin_development1.17021936
82MP0003045_fibrosis1.16673671
83MP0008995_early_reproductive_senescence1.16509691
84MP0009115_abnormal_fat_cell1.16187641
85MP0004742_abnormal_vestibular_system1.15765387
86MP0005646_abnormal_pituitary_gland1.14698342
87MP0000427_abnormal_hair_cycle1.14128444
88MP0002272_abnormal_nervous_system1.12432699
89MP0002184_abnormal_innervation1.12116384
90MP0003698_abnormal_male_reproductive1.12099936
91MP0003252_abnormal_bile_duct1.10888535
92MP0005085_abnormal_gallbladder_physiolo1.10777392
93MP0005365_abnormal_bile_salt1.09756379
94MP0002882_abnormal_neuron_morphology1.09662506
95MP0002734_abnormal_mechanical_nocicepti1.09064720
96MP0000013_abnormal_adipose_tissue1.08421814
97MP0004381_abnormal_hair_follicle1.06748190
98MP0003635_abnormal_synaptic_transmissio1.06389020
99MP0003937_abnormal_limbs/digits/tail_de1.05629125
100MP0002877_abnormal_melanocyte_morpholog1.04359890
101MP0005187_abnormal_penis_morphology1.04032823
102MP0003890_abnormal_embryonic-extraembry1.03949080
103MP0002177_abnormal_outer_ear1.02461909
104MP0002067_abnormal_sensory_capabilities1.01043150
105MP0005266_abnormal_metabolism1.00537095
106MP0005666_abnormal_adipose_tissue0.99987614
107MP0009384_cardiac_valve_regurgitation0.97339575
108MP0001286_abnormal_eye_development0.96214501
109MP0006138_congestive_heart_failure0.96083704
110MP0002837_dystrophic_cardiac_calcinosis0.95607829
111MP0004036_abnormal_muscle_relaxation0.95390030
112MP0009046_muscle_twitch0.94475862
113MP0003119_abnormal_digestive_system0.93686299
114MP0008877_abnormal_DNA_methylation0.93403525
115MP0000579_abnormal_nail_morphology0.93064810
116MP0005171_absent_coat_pigmentation0.91637601
117MP0001299_abnormal_eye_distance/0.89223977
118MP0001929_abnormal_gametogenesis0.88801593
119MP0005375_adipose_tissue_phenotype0.88535524
120MP0001661_extended_life_span0.88506126
121MP0010386_abnormal_urinary_bladder0.88149590
122MP0002234_abnormal_pharynx_morphology0.88113366
123MP0001919_abnormal_reproductive_system0.87853806
124MP0002166_altered_tumor_susceptibility0.87564628
125MP0002138_abnormal_hepatobiliary_system0.87488611
126MP0002295_abnormal_pulmonary_circulatio0.87159372
127MP0001963_abnormal_hearing_physiology0.86937493
128MP0004215_abnormal_myocardial_fiber0.85568442
129MP0003633_abnormal_nervous_system0.85298009
130MP0005379_endocrine/exocrine_gland_phen0.84527271
131MP0003631_nervous_system_phenotype0.83417303
132MP0005647_abnormal_sex_gland0.83061050
133MP0009745_abnormal_behavioral_response0.81679599
134MP0010234_abnormal_vibrissa_follicle0.80617698
135MP0002332_abnormal_exercise_endurance0.80316800
136MP0002063_abnormal_learning/memory/cond0.80050669
137MP0003183_abnormal_peptide_metabolism0.79731504
138MP0002090_abnormal_vision0.79592956
139MP0002572_abnormal_emotion/affect_behav0.78184384
140MP0000537_abnormal_urethra_morphology0.78088229
141MP0001764_abnormal_homeostasis0.77811964
142MP0001177_atelectasis0.77527628
143MP0002697_abnormal_eye_size0.77431362
144MP0003879_abnormal_hair_cell0.76092244
145MP0002152_abnormal_brain_morphology0.74589423
146MP0002210_abnormal_sex_determination0.74393706
147MP0005389_reproductive_system_phenotype0.74309110
148MP0008789_abnormal_olfactory_epithelium0.73102446
149MP0004924_abnormal_behavior0.72351415
150MP0005386_behavior/neurological_phenoty0.72351415
151MP0003315_abnormal_perineum_morphology0.72053462
152MP0000767_abnormal_smooth_muscle0.71882757
153MP0005620_abnormal_muscle_contractility0.71624424
154MP0003763_abnormal_thymus_physiology0.71356137
155MP0009703_decreased_birth_body0.71103052
156MP0005220_abnormal_exocrine_pancreas0.70887540
157MP0000026_abnormal_inner_ear0.70198110
158MP0003935_abnormal_craniofacial_develop0.69785963
159MP0002998_abnormal_bone_remodeling0.69467794
160MP0002249_abnormal_larynx_morphology0.69335539
161MP0003861_abnormal_nervous_system0.69001956
162MP0003943_abnormal_hepatobiliary_system0.68983610
163MP0010352_gastrointestinal_tract_polyps0.68704161
164MP0001544_abnormal_cardiovascular_syste0.68594210
165MP0005385_cardiovascular_system_phenoty0.68594210
166MP0003632_abnormal_nervous_system0.67919757
167MP0000955_abnormal_spinal_cord0.67267292
168MP0003115_abnormal_respiratory_system0.66831520
169MP0000266_abnormal_heart_morphology0.66522036
170MP0001501_abnormal_sleep_pattern0.65253754
171MP0002233_abnormal_nose_morphology0.65134534
172MP0001943_abnormal_respiration0.65046053
173MP0004085_abnormal_heartbeat0.64110385
174MP0000653_abnormal_sex_gland0.64048485
175MP0004272_abnormal_basement_membrane0.63682668
176MP0002160_abnormal_reproductive_system0.63519511
177MP0003948_abnormal_gas_homeostasis0.63058568
178MP0002128_abnormal_blood_circulation0.62974958
179MP0000003_abnormal_adipose_tissue0.62830691
180MP0001958_emphysema0.62293131
181MP0003300_gastrointestinal_ulcer0.62176798
182MP0003690_abnormal_glial_cell0.61269306

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)5.34697085
2Chorioretinal atrophy (HP:0000533)5.06028349
3Congenital stationary night blindness (HP:0007642)4.72932278
4Bony spicule pigmentary retinopathy (HP:0007737)4.64095220
5Central scotoma (HP:0000603)4.61665995
6Abnormal rod and cone electroretinograms (HP:0008323)4.57183951
7Hyporeflexia of lower limbs (HP:0002600)4.51141087
8Dyschromatopsia (HP:0007641)4.44148423
9Abnormality of macular pigmentation (HP:0008002)4.42205101
10Abolished electroretinogram (ERG) (HP:0000550)4.30327081
11Type 1 muscle fiber predominance (HP:0003803)4.19264521
12Pigmentary retinal degeneration (HP:0001146)4.14504694
13Pendular nystagmus (HP:0012043)4.11613863
14Difficulty running (HP:0009046)3.99617664
15Decreased central vision (HP:0007663)3.81779002
16Scotoma (HP:0000575)3.66522943
17Attenuation of retinal blood vessels (HP:0007843)3.54859684
18Exercise-induced muscle cramps (HP:0003710)3.38866995
19Neck muscle weakness (HP:0000467)3.30550215
20EMG: myopathic abnormalities (HP:0003458)3.30039007
21Muscle fiber splitting (HP:0003555)3.19351236
22Subaortic stenosis (HP:0001682)3.16629869
23Abnormality of the left ventricular outflow tract (HP:0011103)3.16629869
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.12508903
25Abnormality of the calf musculature (HP:0001430)3.00769877
26Vitreoretinal degeneration (HP:0000655)3.00658359
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.99782528
28Absent/shortened dynein arms (HP:0200106)2.99782528
29Rimmed vacuoles (HP:0003805)2.98923248
30Postural instability (HP:0002172)2.98197699
31Increased corneal curvature (HP:0100692)2.87009286
32Keratoconus (HP:0000563)2.87009286
33Cone-rod dystrophy (HP:0000548)2.86041472
34Resting tremor (HP:0002322)2.80953116
35Posterior subcapsular cataract (HP:0007787)2.79775846
36Proximal amyotrophy (HP:0007126)2.77979408
37Frequent falls (HP:0002359)2.77652797
38Type II diabetes mellitus (HP:0005978)2.74604096
39Photophobia (HP:0000613)2.73063855
40Macular degeneration (HP:0000608)2.71560525
41Nonprogressive disorder (HP:0003680)2.69277469
42Cerebral aneurysm (HP:0004944)2.68225193
43Lip pit (HP:0100267)2.66616418
44Aortic aneurysm (HP:0004942)2.65473261
45Muscle hypertrophy of the lower extremities (HP:0008968)2.65238733
46Neonatal hypoglycemia (HP:0001998)2.64466220
47Distal arthrogryposis (HP:0005684)2.64442894
48Increased variability in muscle fiber diameter (HP:0003557)2.61444070
49Long clavicles (HP:0000890)2.59896665
50Constricted visual fields (HP:0001133)2.59435573
51Abnormality of skeletal muscle fiber size (HP:0012084)2.59040545
52Centrally nucleated skeletal muscle fibers (HP:0003687)2.56515583
53Severe visual impairment (HP:0001141)2.56375060
54Scapular winging (HP:0003691)2.54806969
55Bundle branch block (HP:0011710)2.54610356
56Asymmetric septal hypertrophy (HP:0001670)2.53907703
57Dysmetric saccades (HP:0000641)2.53751285
58Truncal obesity (HP:0001956)2.50952599
59Sudden death (HP:0001699)2.48309654
60Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46734521
61Obstructive sleep apnea (HP:0002870)2.42956681
62Chronic hepatic failure (HP:0100626)2.40498268
63Abnormality of the nasal septum (HP:0000419)2.38056777
64Gaze-evoked nystagmus (HP:0000640)2.37469971
65Abnormal respiratory motile cilium physiology (HP:0012261)2.36667342
66Generalized hypopigmentation of hair (HP:0011358)2.30959746
67Hyperkalemia (HP:0002153)2.29191611
68Febrile seizures (HP:0002373)2.26768886
69Papillary thyroid carcinoma (HP:0002895)2.23607525
70Exercise-induced myalgia (HP:0003738)2.22658344
71Septo-optic dysplasia (HP:0100842)2.19696876
72Arterial tortuosity (HP:0005116)2.19582829
73Calf muscle hypertrophy (HP:0008981)2.18787602
74Abnormality of the columella (HP:0009929)2.18579877
75Focal motor seizures (HP:0011153)2.17290901
76Toxemia of pregnancy (HP:0100603)2.15100963
77Muscle fiber inclusion bodies (HP:0100299)2.14822247
78Heterotopia (HP:0002282)2.14708175
79Abnormal ciliary motility (HP:0012262)2.13597569
80Absent speech (HP:0001344)2.11725285
81Subcapsular cataract (HP:0000523)2.09577460
82Myopathic facies (HP:0002058)2.09372675
83Hypochromic microcytic anemia (HP:0004840)2.09324290
84Areflexia of lower limbs (HP:0002522)2.08667045
85Foot dorsiflexor weakness (HP:0009027)2.08262752
86Severe Myopia (HP:0011003)2.07830596
87EMG: neuropathic changes (HP:0003445)2.07665082
88Optic nerve hypoplasia (HP:0000609)2.07605193
89Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.06927373
90Vascular tortuosity (HP:0004948)2.06630327
91Spinal cord lesions (HP:0100561)2.05186409
92Syringomyelia (HP:0003396)2.05186409
93Nemaline bodies (HP:0003798)2.03770512
94Degeneration of the lateral corticospinal tracts (HP:0002314)2.03431499
95Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.03431499
96Abnormality of eosinophils (HP:0001879)2.03055164
97Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.02894876
98Abnormality of the foot musculature (HP:0001436)2.02299055
99Choroideremia (HP:0001139)1.99680514
100Round ear (HP:0100830)1.99548365
101Broad-based gait (HP:0002136)1.99538912
102Abnormality of incisor morphology (HP:0011063)1.99109324
103Retinitis pigmentosa (HP:0000510)1.98296368
104Prolonged partial thromboplastin time (HP:0003645)1.95895027
105Absent eyebrow (HP:0002223)1.94092402
106Abnormality of the ischium (HP:0003174)1.91959391
107Congenital sensorineural hearing impairment (HP:0008527)1.91935434
108Abnormality of the corticospinal tract (HP:0002492)1.91790950
109Abnormality of the shoulder girdle musculature (HP:0001435)1.90953849
110Spinal rigidity (HP:0003306)1.90851710
111Midline defect of the nose (HP:0004122)1.90699890
112Ulnar bowing (HP:0003031)1.90191290
113Clumsiness (HP:0002312)1.89191126
114Germ cell neoplasia (HP:0100728)1.86753258
115Cubitus valgus (HP:0002967)1.86177661
116Progressive cerebellar ataxia (HP:0002073)1.85364980
117Increased connective tissue (HP:0009025)1.84960178
118Polar cataract (HP:0010696)1.81919654
119Hyperinsulinemic hypoglycemia (HP:0000825)1.81861103
120Narrow palate (HP:0000189)1.81052788
121Myoglobinuria (HP:0002913)1.79748190
122Eosinophilia (HP:0001880)1.79484798
123Excessive salivation (HP:0003781)1.78733897
124Drooling (HP:0002307)1.78733897
125Steppage gait (HP:0003376)1.77798422
126Fair hair (HP:0002286)1.76696489
127Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74976747
128Overgrowth (HP:0001548)1.73943784
129Blue irides (HP:0000635)1.73268599
130Retinal atrophy (HP:0001105)1.72803918
131Chronic bronchitis (HP:0004469)1.72248461
132Abnormal respiratory epithelium morphology (HP:0012253)1.71931765
133Abnormal respiratory motile cilium morphology (HP:0005938)1.71931765
134Thyroid-stimulating hormone excess (HP:0002925)1.71842918
135Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.71801214
136Muscular dystrophy (HP:0003560)1.71374387
137Hypoplastic ischia (HP:0003175)1.71011947
138Neoplasm of the tracheobronchial system (HP:0100552)1.70481609
139Absent frontal sinuses (HP:0002688)1.69901057
140Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.69017214
141Depressed nasal tip (HP:0000437)1.68303472
142Abnormality of the frontal sinuses (HP:0002687)1.68198114
143Scanning speech (HP:0002168)1.67586623
144Dysdiadochokinesis (HP:0002075)1.66948530
145Urinary urgency (HP:0000012)1.66718702
146Cerebral inclusion bodies (HP:0100314)1.66564019
147Insulin-resistant diabetes mellitus (HP:0000831)1.65988841
148Lower limb muscle weakness (HP:0007340)1.65912310
149Tubulointerstitial nephritis (HP:0001970)1.65500299
150Abnormality of the fingertips (HP:0001211)1.64437521
151Volvulus (HP:0002580)1.63913322
152Macroorchidism (HP:0000053)1.63632397
153Genetic anticipation (HP:0003743)1.63324240
154Intrahepatic cholestasis (HP:0001406)1.63045611
155Anophthalmia (HP:0000528)1.62702707
156Cupped ear (HP:0000378)1.60688755
157Absent septum pellucidum (HP:0001331)1.60217903
158Malignant hyperthermia (HP:0002047)1.59729560
159Aortic dissection (HP:0002647)1.59597351
160Nephronophthisis (HP:0000090)1.59470610
161Epileptic encephalopathy (HP:0200134)1.58168287
162Parakeratosis (HP:0001036)1.57032467
163Protruding tongue (HP:0010808)1.56125467
164Mitral valve prolapse (HP:0001634)1.56057901
165Cystic hygroma (HP:0000476)1.55950402
166Ulnar deviation of the wrist (HP:0003049)1.55926463
167Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.55861574
168Oligodactyly (hands) (HP:0001180)1.55695422
169Thickened helices (HP:0000391)1.55412117
170Hypoplasia of the iris (HP:0007676)1.55382597
171Alveolar cell carcinoma (HP:0006519)1.54594702
172Ventricular fibrillation (HP:0001663)1.54217490
173Sleep apnea (HP:0010535)1.53469265
174Abnormality of the septum pellucidum (HP:0007375)1.52669309
175Thoracic kyphosis (HP:0002942)1.52202982
176Ulnar claw (HP:0001178)1.51990002
177Prominent nose (HP:0000448)1.51550169
178Right ventricular cardiomyopathy (HP:0011663)1.50982434
179Vertebral arch anomaly (HP:0008438)1.50960134
180Distal lower limb amyotrophy (HP:0008944)1.50261568
181Mitral stenosis (HP:0001718)1.50057789
182Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.48819249
183Urinary bladder sphincter dysfunction (HP:0002839)1.47297099
184Colitis (HP:0002583)1.46051947
185Gastrointestinal infarctions (HP:0005244)1.45663227
186Papilledema (HP:0001085)1.45200683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.05225887
2MAP3K62.79729379
3INSRR2.66259891
4MUSK2.50808372
5MKNK22.40093540
6CDK122.37696748
7TTN2.24317022
8LATS12.13300631
9TNIK2.09911734
10PNCK2.08659203
11MARK32.00268881
12PINK11.95809465
13CDK31.88427899
14MAPK131.75463848
15PHKG11.69671567
16PHKG21.69671567
17FRK1.68507289
18GRK71.67457297
19GRK11.62727769
20MAPK151.62704887
21CDK91.54711887
22SRPK11.49805709
23SGK21.49075044
24LATS21.47789873
25MAP2K71.45627896
26IRAK21.44616352
27OBSCN1.44412928
28NLK1.42207287
29MAP3K41.41705919
30MAP2K41.40173689
31SGK4941.36671575
32SGK2231.36671575
33MAP2K31.35783231
34STK391.34295776
35MKNK11.32973425
36YES11.30655646
37FGFR21.29408398
38MARK11.28502492
39PIK3CG1.27091760
40HIPK21.25188465
41TRPM71.24140256
42NEK61.22567674
43ICK1.18755959
44BMPR21.17114682
45PKN11.15264104
46PRPF4B1.13645274
47AKT31.09221840
48MAP3K91.06280393
49EEF2K1.05634682
50CAMK1G1.05511733
51TRIB31.05256420
52MAP3K71.04783616
53RIPK11.04715290
54MAP3K101.04635089
55WNK11.03918496
56PDGFRB1.02776950
57CSNK1G11.02212860
58RET1.02146160
59MAPK120.99756639
60CAMK1D0.98071964
61PDGFRA0.97538415
62MTOR0.97006939
63MAP3K10.95049329
64ERBB30.94640445
65STK380.92919284
66SGK30.92580814
67IRAK10.90638671
68TGFBR20.89513579
69BRD40.88351091
70CSNK1A1L0.88211396
71MAPKAPK50.87509077
72PRKAA20.86880284
73DYRK1A0.84995159
74MAP3K130.81856187
75FER0.79719121
76MAP3K20.79285777
77DYRK20.77134885
78GRK50.76279660
79PRKD20.75896535
80JAK10.74808002
81NTRK30.73265822
82PRKD30.72758990
83CAMK2A0.71946568
84PRKAA10.70302627
85CSNK1D0.69753630
86CSNK1G20.69461372
87MELK0.69443016
88SIK20.68096145
89TLK10.67563635
90ERBB40.67215707
91SGK10.67187134
92ZAK0.66170914
93PKN20.65794056
94EPHA40.65760043
95STK38L0.65643312
96PDK10.65244470
97EIF2AK20.64973158
98WNK40.64881221
99TAOK10.64875197
100PDK20.64859443
101PRKG10.64418932
102CLK10.63603147
103KSR20.62852334
104MAP3K50.62445273
105PDPK10.61730180
106NUAK10.59994043
107NEK90.59804706
108UHMK10.59296114
109FGR0.58478207
110CSNK1G30.58226677
111CDK60.57853987
112PAK60.56929426
113FGFR10.56665085
114STK110.56644623
115MAPK70.56478336
116FGFR30.55962837
117MARK20.55822627
118RPS6KA50.55814053
119PAK30.55131074
120CAMK40.55085922
121CAMK2B0.54634767
122HCK0.54127494
123OXSR10.53882374
124GSK3A0.53178350
125CAMK2D0.52917924
126RIPK40.52857259
127NTRK20.52730057
128PIK3CA0.52620292
129CAMK10.52246877
130KSR10.51733168
131CDK50.51402480
132RPS6KA20.50505868
133MAPK100.50043495
134CDK80.48484463
135DMPK0.46455901
136RPS6KC10.46005968
137RPS6KL10.46005968
138MOS0.45708848
139DYRK1B0.44513454
140RPS6KA10.44449408
141MAP2K60.44223256
142TAOK30.44001651
143PRKCE0.43823100
144RPS6KA30.43811206
145DYRK30.43554531
146RPS6KB10.43528105
147BTK0.42408590
148MAP3K30.42112180
149DDR20.40317383
150TYRO30.39906802
151ROCK10.38681940
152JAK20.37649997
153RPS6KA60.34404658

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.77343594
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.45569621
3Nitrogen metabolism_Homo sapiens_hsa009102.11191072
4Nicotine addiction_Homo sapiens_hsa050332.05043630
5Ether lipid metabolism_Homo sapiens_hsa005652.00131096
6Glutamatergic synapse_Homo sapiens_hsa047241.89434750
7Circadian rhythm_Homo sapiens_hsa047101.85187931
8Olfactory transduction_Homo sapiens_hsa047401.80305391
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.70591618
10GABAergic synapse_Homo sapiens_hsa047271.61273371
11Long-term potentiation_Homo sapiens_hsa047201.59729092
12Taste transduction_Homo sapiens_hsa047421.52855146
13Long-term depression_Homo sapiens_hsa047301.48381228
14Circadian entrainment_Homo sapiens_hsa047131.46158246
15Serotonergic synapse_Homo sapiens_hsa047261.45591648
16Non-small cell lung cancer_Homo sapiens_hsa052231.45572423
17Morphine addiction_Homo sapiens_hsa050321.40773035
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39716855
19mTOR signaling pathway_Homo sapiens_hsa041501.37372819
20Insulin secretion_Homo sapiens_hsa049111.37088433
21Renin secretion_Homo sapiens_hsa049241.34281208
22Dorso-ventral axis formation_Homo sapiens_hsa043201.26482948
23Retinol metabolism_Homo sapiens_hsa008301.26324315
24Axon guidance_Homo sapiens_hsa043601.23905344
25AMPK signaling pathway_Homo sapiens_hsa041521.23334788
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22935243
27Adipocytokine signaling pathway_Homo sapiens_hsa049201.22523738
28Insulin signaling pathway_Homo sapiens_hsa049101.21062391
29Dopaminergic synapse_Homo sapiens_hsa047281.20999585
30Glioma_Homo sapiens_hsa052141.19177142
31B cell receptor signaling pathway_Homo sapiens_hsa046621.18325444
32Linoleic acid metabolism_Homo sapiens_hsa005911.16783810
33Ovarian steroidogenesis_Homo sapiens_hsa049131.16200723
34Cholinergic synapse_Homo sapiens_hsa047251.15672559
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14906403
36Amphetamine addiction_Homo sapiens_hsa050311.13126058
37Glucagon signaling pathway_Homo sapiens_hsa049221.12534055
38ABC transporters_Homo sapiens_hsa020101.10820441
39Oxytocin signaling pathway_Homo sapiens_hsa049211.09250256
40VEGF signaling pathway_Homo sapiens_hsa043701.08647007
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08602393
42Chronic myeloid leukemia_Homo sapiens_hsa052201.07890435
43Focal adhesion_Homo sapiens_hsa045101.07676965
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07264055
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06593330
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.03934174
47Wnt signaling pathway_Homo sapiens_hsa043101.03870125
48Lysine degradation_Homo sapiens_hsa003101.03528521
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02337614
50cAMP signaling pathway_Homo sapiens_hsa040241.01604526
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01503035
52Calcium signaling pathway_Homo sapiens_hsa040201.00383846
53Fatty acid elongation_Homo sapiens_hsa000620.99626716
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99500975
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.99461277
56GnRH signaling pathway_Homo sapiens_hsa049120.99054399
57Fatty acid biosynthesis_Homo sapiens_hsa000610.98938312
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97561105
59Arginine biosynthesis_Homo sapiens_hsa002200.97248717
60T cell receptor signaling pathway_Homo sapiens_hsa046600.97213184
61Acute myeloid leukemia_Homo sapiens_hsa052210.94982693
62Melanogenesis_Homo sapiens_hsa049160.94435508
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94268426
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93354337
65Pancreatic cancer_Homo sapiens_hsa052120.93310791
66Chemical carcinogenesis_Homo sapiens_hsa052040.93010482
67Salivary secretion_Homo sapiens_hsa049700.92654914
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91964481
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89882234
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.88489726
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.85994052
72Small cell lung cancer_Homo sapiens_hsa052220.85966630
73Sphingolipid metabolism_Homo sapiens_hsa006000.84346794
74Prostate cancer_Homo sapiens_hsa052150.82777257
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82610807
76Inositol phosphate metabolism_Homo sapiens_hsa005620.82358160
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.82215937
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.81443338
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80856696
80Type II diabetes mellitus_Homo sapiens_hsa049300.80430864
81Platelet activation_Homo sapiens_hsa046110.80380086
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.78374027
83Osteoclast differentiation_Homo sapiens_hsa043800.77356942
84Amoebiasis_Homo sapiens_hsa051460.75935996
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75436548
86Thyroid cancer_Homo sapiens_hsa052160.72290341
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69989306
88MAPK signaling pathway_Homo sapiens_hsa040100.69690052
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69664964
90Tight junction_Homo sapiens_hsa045300.69592502
91Basal cell carcinoma_Homo sapiens_hsa052170.69570276
92Basal transcription factors_Homo sapiens_hsa030220.69509124
93Proteoglycans in cancer_Homo sapiens_hsa052050.69299290
94FoxO signaling pathway_Homo sapiens_hsa040680.68971960
95Arachidonic acid metabolism_Homo sapiens_hsa005900.68748498
96Choline metabolism in cancer_Homo sapiens_hsa052310.66692917
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66662485
98MicroRNAs in cancer_Homo sapiens_hsa052060.66298381
99HIF-1 signaling pathway_Homo sapiens_hsa040660.66078578
100Colorectal cancer_Homo sapiens_hsa052100.65991696
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65543324
102TGF-beta signaling pathway_Homo sapiens_hsa043500.65279367
103Adherens junction_Homo sapiens_hsa045200.64828806
104Hepatitis B_Homo sapiens_hsa051610.63473013
105Hippo signaling pathway_Homo sapiens_hsa043900.62504516
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61516762
107ECM-receptor interaction_Homo sapiens_hsa045120.61480152
108Alcoholism_Homo sapiens_hsa050340.61371636
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61074741
110Prolactin signaling pathway_Homo sapiens_hsa049170.61064713
111Endometrial cancer_Homo sapiens_hsa052130.60943763
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.59796464
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59736879
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59119549
115Measles_Homo sapiens_hsa051620.58143205
116Toxoplasmosis_Homo sapiens_hsa051450.58057979
117Complement and coagulation cascades_Homo sapiens_hsa046100.57965593
118Chemokine signaling pathway_Homo sapiens_hsa040620.57386430
119Dilated cardiomyopathy_Homo sapiens_hsa054140.57019425
120Renal cell carcinoma_Homo sapiens_hsa052110.56914910
121ErbB signaling pathway_Homo sapiens_hsa040120.56850682
122Ras signaling pathway_Homo sapiens_hsa040140.56587857
123Apoptosis_Homo sapiens_hsa042100.55925622
124Insulin resistance_Homo sapiens_hsa049310.55893132
125Melanoma_Homo sapiens_hsa052180.55736400
126Estrogen signaling pathway_Homo sapiens_hsa049150.55010361
127Cocaine addiction_Homo sapiens_hsa050300.54623727
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54386736
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53711166
130Gastric acid secretion_Homo sapiens_hsa049710.53270869
131NF-kappa B signaling pathway_Homo sapiens_hsa040640.53234431
132TNF signaling pathway_Homo sapiens_hsa046680.52849495
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52797511
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51607870
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50850866
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50470396
137Hedgehog signaling pathway_Homo sapiens_hsa043400.48453917
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47470448
139Gap junction_Homo sapiens_hsa045400.45013778
140mRNA surveillance pathway_Homo sapiens_hsa030150.44503695
141Butanoate metabolism_Homo sapiens_hsa006500.43989734
142Tyrosine metabolism_Homo sapiens_hsa003500.43645949
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43238148
144PPAR signaling pathway_Homo sapiens_hsa033200.41972073
145Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41936986

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