ZRANB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.60294728
2synaptic vesicle exocytosis (GO:0016079)5.15054523
3vocalization behavior (GO:0071625)5.12037874
4neuron cell-cell adhesion (GO:0007158)5.05002312
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.02998066
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.85377445
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.84960152
8ionotropic glutamate receptor signaling pathway (GO:0035235)4.84798623
9neuronal action potential propagation (GO:0019227)4.80806632
10locomotory exploration behavior (GO:0035641)4.76145297
11glutamate receptor signaling pathway (GO:0007215)4.71833315
12protein localization to synapse (GO:0035418)4.68047326
13synaptic vesicle maturation (GO:0016188)4.43909233
14regulation of glutamate receptor signaling pathway (GO:1900449)4.41636734
15regulation of synaptic vesicle exocytosis (GO:2000300)4.40652156
16glutamate secretion (GO:0014047)4.39977373
17synaptic transmission, glutamatergic (GO:0035249)4.33298677
18neuron-neuron synaptic transmission (GO:0007270)4.30062313
19gamma-aminobutyric acid signaling pathway (GO:0007214)4.30053752
20nuclear pore organization (GO:0006999)4.25220530
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.19188841
22G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.16432980
23nuclear pore complex assembly (GO:0051292)4.13606513
24chromatin remodeling at centromere (GO:0031055)4.11490384
25neurotransmitter secretion (GO:0007269)4.08225244
26synaptic vesicle docking involved in exocytosis (GO:0016081)4.08105936
27CENP-A containing nucleosome assembly (GO:0034080)4.07431362
28neuron recognition (GO:0008038)3.94555983
29transmission of nerve impulse (GO:0019226)3.91864738
30presynaptic membrane assembly (GO:0097105)3.90760052
31DNA topological change (GO:0006265)3.89019339
32exploration behavior (GO:0035640)3.85064040
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.84504027
34cerebellar Purkinje cell differentiation (GO:0021702)3.78355284
35regulation of synaptic vesicle transport (GO:1902803)3.77659208
36establishment of integrated proviral latency (GO:0075713)3.73397575
37DNA double-strand break processing (GO:0000729)3.71719462
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.70126682
39DNA replication checkpoint (GO:0000076)3.69906742
40mRNA splice site selection (GO:0006376)3.69325282
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.69257751
42regulation of long-term neuronal synaptic plasticity (GO:0048169)3.69007113
43mitotic sister chromatid cohesion (GO:0007064)3.66672465
44presynaptic membrane organization (GO:0097090)3.65911021
45positive regulation of synapse maturation (GO:0090129)3.64944064
46DNA ligation (GO:0006266)3.60224015
47axonal fasciculation (GO:0007413)3.59031817
48negative regulation of RNA splicing (GO:0033119)3.57234757
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.56407146
50regulation of neuronal synaptic plasticity (GO:0048168)3.55297309
51intra-S DNA damage checkpoint (GO:0031573)3.54347244
52DNA unwinding involved in DNA replication (GO:0006268)3.54134244
53regulation of postsynaptic membrane potential (GO:0060078)3.53869500
54IMP biosynthetic process (GO:0006188)3.53594576
55DNA strand elongation involved in DNA replication (GO:0006271)3.53004063
56negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.51744177
57postsynaptic membrane organization (GO:0001941)3.51637166
58gamma-aminobutyric acid transport (GO:0015812)3.51620016
59neurotransmitter-gated ion channel clustering (GO:0072578)3.51499951
60long-term memory (GO:0007616)3.51232483
61histone exchange (GO:0043486)3.48243764
62negative regulation of DNA-dependent DNA replication (GO:2000104)3.48155854
63behavioral fear response (GO:0001662)3.46220524
64behavioral defense response (GO:0002209)3.46220524
65termination of RNA polymerase II transcription (GO:0006369)3.44950768
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.44165277
67regulation of helicase activity (GO:0051095)3.44037212
68regulation of centriole replication (GO:0046599)3.43840355
69double-strand break repair via nonhomologous end joining (GO:0006303)3.43276843
70non-recombinational repair (GO:0000726)3.43276843
71regulation of synapse structural plasticity (GO:0051823)3.43219879
72positive regulation of membrane potential (GO:0045838)3.43154551
73regulation of DNA endoreduplication (GO:0032875)3.42940329
74neurotransmitter transport (GO:0006836)3.42883177
75histone H2A acetylation (GO:0043968)3.42059543
76protein localization to kinetochore (GO:0034501)3.38979399
77DNA replication-independent nucleosome organization (GO:0034724)3.38302859
78DNA replication-independent nucleosome assembly (GO:0006336)3.38302859
79positive regulation of histone H3-K4 methylation (GO:0051571)3.37188491
80telomere maintenance via semi-conservative replication (GO:0032201)3.36305333
81layer formation in cerebral cortex (GO:0021819)3.34725545
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.34596481
83cerebellar granule cell differentiation (GO:0021707)3.34454729
84regulation of dendritic spine morphogenesis (GO:0061001)3.32345849
85DNA strand elongation (GO:0022616)3.31696944
86synaptic vesicle endocytosis (GO:0048488)3.31604547
87long-term synaptic potentiation (GO:0060291)3.31599753
88positive regulation of synapse assembly (GO:0051965)3.30739795
89positive regulation of dendritic spine morphogenesis (GO:0061003)3.29908914
90formation of translation preinitiation complex (GO:0001731)3.29863455
91fear response (GO:0042596)3.28199607
92mitotic recombination (GO:0006312)3.28007655
93response to histamine (GO:0034776)3.27223669
94somatic hypermutation of immunoglobulin genes (GO:0016446)3.26406931
95somatic diversification of immune receptors via somatic mutation (GO:0002566)3.26406931
96negative regulation of mRNA processing (GO:0050686)3.26329847
97cellular potassium ion homeostasis (GO:0030007)3.25683947
98kinetochore organization (GO:0051383)3.25394465
99positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.25185034
100purine nucleobase biosynthetic process (GO:0009113)3.24799694
101regulation of neurotransmitter secretion (GO:0046928)3.24773436
102ribosomal large subunit biogenesis (GO:0042273)3.23703824
103ribosomal small subunit assembly (GO:0000028)3.22976528
104IMP metabolic process (GO:0046040)3.22934527
105telomere maintenance via recombination (GO:0000722)3.20966566
106membrane depolarization during action potential (GO:0086010)3.17735204
107regulation of mitotic spindle checkpoint (GO:1903504)3.16541643
108regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.16541643
109membrane depolarization (GO:0051899)3.15959297
110DNA damage response, detection of DNA damage (GO:0042769)3.15377577
111dendritic spine morphogenesis (GO:0060997)3.14796828
112negative regulation of mitotic sister chromatid segregation (GO:0033048)3.13231154
113negative regulation of mitotic sister chromatid separation (GO:2000816)3.13231154
114negative regulation of sister chromatid segregation (GO:0033046)3.13231154
115negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.13231154
116negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.13231154
117regulation of synaptic plasticity (GO:0048167)3.12120129
118sister chromatid segregation (GO:0000819)3.11701902
119membrane hyperpolarization (GO:0060081)3.11612281
120nucleotide-excision repair, DNA gap filling (GO:0006297)3.11475503
121mitotic spindle checkpoint (GO:0071174)3.09707673
122regulation of neurotransmitter levels (GO:0001505)3.09688666
123regulation of vesicle fusion (GO:0031338)3.09244636
124negative regulation of chromosome segregation (GO:0051985)3.08438071
125attachment of spindle microtubules to kinetochore (GO:0008608)3.07681112
126proline transport (GO:0015824)3.07361789
127mechanosensory behavior (GO:0007638)3.07057031
128negative regulation of DNA recombination (GO:0045910)3.06889085
129spindle checkpoint (GO:0031577)3.05131827
130replication fork processing (GO:0031297)3.04856736
131positive regulation of neurotransmitter transport (GO:0051590)3.04252367
132startle response (GO:0001964)3.03837096
133mitotic spindle assembly checkpoint (GO:0007094)3.01082336
134spindle assembly checkpoint (GO:0071173)3.00731885
135mitotic G2/M transition checkpoint (GO:0044818)3.00446296
136behavioral response to cocaine (GO:0048148)3.00162304
137ribosome assembly (GO:0042255)2.99990548
138RNA splicing, via transesterification reactions (GO:0000375)2.98960297
139regulation of neurotransmitter transport (GO:0051588)2.98691508
140regulation of mRNA splicing, via spliceosome (GO:0048024)2.97989008
141positive regulation of dendritic spine development (GO:0060999)2.97317506
142synapsis (GO:0007129)2.96215685
143synapse assembly (GO:0007416)2.95755034
144synaptic transmission (GO:0007268)2.95578758
145learning (GO:0007612)2.95380510
146regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.95232003
147rRNA modification (GO:0000154)2.95161781
148positive regulation of neurotransmitter secretion (GO:0001956)2.95127874
149rRNA methylation (GO:0031167)2.94866066
150mRNA splicing, via spliceosome (GO:0000398)2.94426565
151RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.94426565
152regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92361319
153regulation of dendritic spine development (GO:0060998)2.92256066
154regulation of mitotic sister chromatid separation (GO:0010965)2.91385833
155regulation of mitotic sister chromatid segregation (GO:0033047)2.91385833
156regulation of sister chromatid segregation (GO:0033045)2.91385833
157mating behavior (GO:0007617)2.91319710
158RNA-dependent DNA replication (GO:0006278)2.91285970
159sister chromatid cohesion (GO:0007062)2.91243448
160positive regulation of synaptic transmission, GABAergic (GO:0032230)2.90703257
161auditory behavior (GO:0031223)2.90461386
162nucleobase biosynthetic process (GO:0046112)2.90314958
163regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.89545395
164regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89545395
165negative regulation of mRNA metabolic process (GO:1903312)2.89467661
166cochlea development (GO:0090102)2.88890385
167regulation of centrosome duplication (GO:0010824)2.88856638
168innervation (GO:0060384)2.88508162
169organelle disassembly (GO:1903008)2.87987150
170oxidative phosphorylation (GO:0006119)2.87764250
171telomere maintenance via telomerase (GO:0007004)2.87598838
172mitotic nuclear envelope disassembly (GO:0007077)2.86864094
173pore complex assembly (GO:0046931)2.85766277
174centriole replication (GO:0007099)2.85259514
175maturation of SSU-rRNA (GO:0030490)2.84733897
176postreplication repair (GO:0006301)2.84382439
177protein localization to chromosome, centromeric region (GO:0071459)2.84095145
178meiotic chromosome segregation (GO:0045132)2.83851829
179monoubiquitinated protein deubiquitination (GO:0035520)2.83239805
180mitotic sister chromatid segregation (GO:0000070)2.83145818
181regulation of synapse assembly (GO:0051963)2.83043423
182RNA export from nucleus (GO:0006405)2.82262480
183regulation of centrosome cycle (GO:0046605)2.82254887
184cell differentiation in hindbrain (GO:0021533)2.81371588
185adult walking behavior (GO:0007628)2.80317307
186intraspecies interaction between organisms (GO:0051703)2.80267569
187social behavior (GO:0035176)2.80267569
188synapse organization (GO:0050808)2.80247820
189regulation of synapse maturation (GO:0090128)2.80169728
190spliceosomal complex assembly (GO:0000245)2.79977028
191ribonucleoprotein complex disassembly (GO:0032988)2.79660503
192positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.78563603
193histone mRNA metabolic process (GO:0008334)2.78176948
194mRNA export from nucleus (GO:0006406)2.77678319
195regulation of glutamate secretion (GO:0014048)2.77493746
196DNA replication initiation (GO:0006270)2.77358795
197regulation of synaptic transmission (GO:0050804)2.77090656
198mismatch repair (GO:0006298)2.76296629
199vesicle transport along microtubule (GO:0047496)2.76155895
200regulation of voltage-gated calcium channel activity (GO:1901385)2.75540430

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.32620014
2EZH2_22144423_ChIP-Seq_EOC_Human6.03490901
3GBX2_23144817_ChIP-Seq_PC3_Human4.27578331
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.82683183
5* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.68808312
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.25643489
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.25204291
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.17072055
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.79631493
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.77600225
11* ELK1_19687146_ChIP-ChIP_HELA_Human2.77375543
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.74333276
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67862309
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64431736
15* TAF15_26573619_Chip-Seq_HEK293_Human2.58855357
16* REST_21632747_ChIP-Seq_MESCs_Mouse2.52288620
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41890383
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.41165930
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.38184557
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.32630098
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31047657
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30080460
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26701426
24RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26701426
25* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26267910
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26139615
27* FUS_26573619_Chip-Seq_HEK293_Human2.25127357
28* VDR_23849224_ChIP-Seq_CD4+_Human2.23660712
29RARB_27405468_Chip-Seq_BRAIN_Mouse2.22760519
30JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21700258
31* ETS1_20019798_ChIP-Seq_JURKAT_Human2.19961880
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19582521
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17308022
34* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17241261
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.16726527
36* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16044641
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15038352
38EED_16625203_ChIP-ChIP_MESCs_Mouse2.14193588
39PADI4_21655091_ChIP-ChIP_MCF-7_Human2.11228262
40POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08044568
41* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.05622444
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.05319469
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05210428
44ZNF274_21170338_ChIP-Seq_K562_Hela2.04956784
45* FOXP3_21729870_ChIP-Seq_TREG_Human2.02897721
46ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01508159
47E2F1_21310950_ChIP-Seq_MCF-7_Human2.01170291
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00760994
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98001026
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.97355309
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.94206307
52* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93186488
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.92492704
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92029368
55TTF2_22483619_ChIP-Seq_HELA_Human1.89177631
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88164288
57P300_19829295_ChIP-Seq_ESCs_Human1.86830582
58DROSHA_22980978_ChIP-Seq_HELA_Human1.86799331
59SMAD4_21799915_ChIP-Seq_A2780_Human1.85715750
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84321971
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83320894
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.80490509
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.73817827
64MYC_18940864_ChIP-ChIP_HL60_Human1.70831045
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70772454
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70215495
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69609966
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67313413
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66008401
70AR_21572438_ChIP-Seq_LNCaP_Human1.65234109
71* DCP1A_22483619_ChIP-Seq_HELA_Human1.64487150
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61931953
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.60782553
74* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59964774
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59173973
76* XRN2_22483619_ChIP-Seq_HELA_Human1.58952156
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.58047343
78IGF1R_20145208_ChIP-Seq_DFB_Human1.55263280
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53797389
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51888911
81NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50819285
82* EWS_26573619_Chip-Seq_HEK293_Human1.49549565
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47773383
84RNF2_27304074_Chip-Seq_NSC_Mouse1.47172103
85* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47103670
86AR_21909140_ChIP-Seq_LNCAP_Human1.46559390
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.43994699
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42947442
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40444072
90STAT3_23295773_ChIP-Seq_U87_Human1.39568778
91ER_23166858_ChIP-Seq_MCF-7_Human1.39129827
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39107692
93HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37576178
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.37198910
95TP63_19390658_ChIP-ChIP_HaCaT_Human1.36504509
96THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35426499
97AR_25329375_ChIP-Seq_VCAP_Human1.35249905
98EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32879099
99PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30298129
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30255880
101TCF4_23295773_ChIP-Seq_U87_Human1.28658666
102GABP_19822575_ChIP-Seq_HepG2_Human1.28159346
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27518927
104TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25023509
105TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24919306
106E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24696306
107SOX9_26525672_Chip-Seq_HEART_Mouse1.24608980
108MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24515738
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23782343
110CIITA_25753668_ChIP-Seq_RAJI_Human1.23686200
111MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22846256
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22099785
113* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21484422
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.20853066
115SRF_21415370_ChIP-Seq_HL-1_Mouse1.18742858
116NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18725606
117* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18302720
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17879144
119* NANOG_18555785_Chip-Seq_ESCs_Mouse1.16946184
120ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16673008
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16492715
122HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16219859
123JUN_21703547_ChIP-Seq_K562_Human1.16031909
124MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15844131
125RUNX2_22187159_ChIP-Seq_PCA_Human1.14423970
126SMAD_19615063_ChIP-ChIP_OVARY_Human1.14387897
127VDR_22108803_ChIP-Seq_LS180_Human1.13264666
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12002994
129* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10890376
130NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10490098
131POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10399060
132AR_19668381_ChIP-Seq_PC3_Human1.09337064
133CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08386175
134PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07415907
135TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07355765
136CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07297908
137TP53_16413492_ChIP-PET_HCT116_Human1.06558348
138FLI1_27457419_Chip-Seq_LIVER_Mouse1.06491236
139ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06054348
140SOX2_16153702_ChIP-ChIP_HESCs_Human1.05824295
141TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05546644
142POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05546644
143* KDM5A_27292631_Chip-Seq_BREAST_Human1.04708733
144HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04539253
145MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03045249
146POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02209480
147E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01960144
148NANOG_16153702_ChIP-ChIP_HESCs_Human1.00993360
149P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00815609
150* E2F1_18555785_Chip-Seq_ESCs_Mouse0.98786409
151PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98772951
152NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97131452
153BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96926823
154* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96167626
155RING1B_27294783_Chip-Seq_ESCs_Mouse0.96040009
156SALL1_21062744_ChIP-ChIP_HESCs_Human0.95997223
157EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95561498
158ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95180469
159ERG_21242973_ChIP-ChIP_JURKAT_Human0.94819931
160* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94553503
161* PRDM14_20953172_ChIP-Seq_ESCs_Human0.94491664
162FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93483285
163ARNT_22903824_ChIP-Seq_MCF-7_Human0.93122396
164* P53_22387025_ChIP-Seq_ESCs_Mouse0.92201159
165CMYC_18555785_Chip-Seq_ESCs_Mouse0.92065937
166WT1_19549856_ChIP-ChIP_CCG9911_Human0.92053498
167IRF1_19129219_ChIP-ChIP_H3396_Human0.87375768
168EZH2_27294783_Chip-Seq_NPCs_Mouse0.84436129
169GATA1_22025678_ChIP-Seq_K562_Human0.82645342
170EGR1_19374776_ChIP-ChIP_THP-1_Human0.77904413
171BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77601208
172YY1_21170310_ChIP-Seq_MESCs_Mouse0.76839504
173SOX2_18555785_ChIP-Seq_MESCs_Mouse0.76706798
174GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.75868179
175SUZ12_27294783_Chip-Seq_NPCs_Mouse0.75293429

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.39098052
2MP0003880_abnormal_central_pattern5.09100730
3MP0008057_abnormal_DNA_replication4.76489600
4MP0010094_abnormal_chromosome_stability4.22165686
5MP0008058_abnormal_DNA_repair4.05146925
6MP0003635_abnormal_synaptic_transmissio3.75422252
7MP0009745_abnormal_behavioral_response3.24774565
8MP0009046_muscle_twitch3.19749667
9MP0004957_abnormal_blastocyst_morpholog3.06270584
10MP0002063_abnormal_learning/memory/cond3.03089783
11MP0004270_analgesia3.02573467
12MP0002064_seizures2.99141878
13MP0003693_abnormal_embryo_hatching2.94653923
14MP0001968_abnormal_touch/_nociception2.91652536
15MP0003111_abnormal_nucleus_morphology2.82800398
16MP0002572_abnormal_emotion/affect_behav2.67002331
17MP0002272_abnormal_nervous_system2.65612186
18MP0003077_abnormal_cell_cycle2.55796942
19MP0002736_abnormal_nociception_after2.53669853
20MP0002734_abnormal_mechanical_nocicepti2.42064983
21MP0001486_abnormal_startle_reflex2.39471658
22MP0002735_abnormal_chemical_nociception2.25438589
23MP0005423_abnormal_somatic_nervous2.21558741
24MP0001440_abnormal_grooming_behavior2.20921426
25MP0001501_abnormal_sleep_pattern2.17935518
26MP0002009_preneoplasia2.13521465
27MP0008007_abnormal_cellular_replicative2.11644027
28MP0003787_abnormal_imprinting2.10642355
29MP0002067_abnormal_sensory_capabilities2.07602566
30MP0008932_abnormal_embryonic_tissue2.02732217
31MP0002396_abnormal_hematopoietic_system2.02433884
32MP0008995_early_reproductive_senescence2.01789956
33MP0009697_abnormal_copulation1.96730193
34MP0001529_abnormal_vocalization1.93557296
35MP0000778_abnormal_nervous_system1.92549007
36MP0002184_abnormal_innervation1.89259265
37MP0003786_premature_aging1.83071909
38MP0006276_abnormal_autonomic_nervous1.82176337
39MP0002822_catalepsy1.79306538
40MP0003890_abnormal_embryonic-extraembry1.78146480
41MP0003122_maternal_imprinting1.78086234
42MP0003567_abnormal_fetal_cardiomyocyte1.71313479
43MP0001970_abnormal_pain_threshold1.69173897
44MP0004924_abnormal_behavior1.68643687
45MP0005386_behavior/neurological_phenoty1.68643687
46MP0001188_hyperpigmentation1.68375392
47MP0002733_abnormal_thermal_nociception1.67850638
48MP0001293_anophthalmia1.67689481
49MP0002557_abnormal_social/conspecific_i1.65939591
50MP0008569_lethality_at_weaning1.60861923
51MP0001984_abnormal_olfaction1.55800612
52MP0004142_abnormal_muscle_tone1.54949328
53MP0004147_increased_porphyrin_level1.54559109
54MP0005646_abnormal_pituitary_gland1.52116708
55MP0004811_abnormal_neuron_physiology1.49798573
56MP0000350_abnormal_cell_proliferation1.48441579
57MP0000955_abnormal_spinal_cord1.47212574
58MP0003123_paternal_imprinting1.43051427
59MP0002882_abnormal_neuron_morphology1.42840374
60MP0003121_genomic_imprinting1.38923270
61MP0003718_maternal_effect1.38246912
62MP0001730_embryonic_growth_arrest1.37552179
63MP0002066_abnormal_motor_capabilities/c1.36732468
64MP0001697_abnormal_embryo_size1.36162067
65MP0008877_abnormal_DNA_methylation1.35614024
66MP0001905_abnormal_dopamine_level1.34992659
67MP0003879_abnormal_hair_cell1.32300563
68MP0004145_abnormal_muscle_electrophysio1.31817447
69MP0002084_abnormal_developmental_patter1.31609680
70MP0009780_abnormal_chondrocyte_physiolo1.31154937
71MP0003937_abnormal_limbs/digits/tail_de1.31000190
72MP0008789_abnormal_olfactory_epithelium1.28986095
73MP0002909_abnormal_adrenal_gland1.26028039
74MP0005551_abnormal_eye_electrophysiolog1.24753545
75MP0001672_abnormal_embryogenesis/_devel1.24687622
76MP0005380_embryogenesis_phenotype1.24687622
77MP0005645_abnormal_hypothalamus_physiol1.22215142
78MP0002210_abnormal_sex_determination1.21020567
79MP0006035_abnormal_mitochondrial_morpho1.20250672
80MP0002152_abnormal_brain_morphology1.19846962
81MP0003984_embryonic_growth_retardation1.17489254
82MP0004197_abnormal_fetal_growth/weight/1.16223195
83MP0002638_abnormal_pupillary_reflex1.15546820
84MP0001502_abnormal_circadian_rhythm1.14793191
85MP0002088_abnormal_embryonic_growth/wei1.14428588
86MP0001929_abnormal_gametogenesis1.13724455
87MP0009672_abnormal_birth_weight1.12498489
88MP0001286_abnormal_eye_development1.12374390
89MP0010307_abnormal_tumor_latency1.12303748
90MP0006072_abnormal_retinal_apoptosis1.10939321
91MP0004885_abnormal_endolymph1.10705388
92MP0004215_abnormal_myocardial_fiber1.09139706
93MP0001145_abnormal_male_reproductive1.08483967
94MP0001485_abnormal_pinna_reflex1.08369234
95MP0002938_white_spotting1.08102182
96MP0003221_abnormal_cardiomyocyte_apopto1.07350225
97MP0002160_abnormal_reproductive_system1.05960975
98MP0000631_abnormal_neuroendocrine_gland1.04631636
99MP0004133_heterotaxia1.03438304
100MP0004808_abnormal_hematopoietic_stem1.03256698
101MP0002085_abnormal_embryonic_tissue1.02618028
102MP0003329_amyloid_beta_deposits1.02173927
103MP0009703_decreased_birth_body1.02153275
104MP0000653_abnormal_sex_gland1.01750901
105MP0000569_abnormal_digit_pigmentation1.01741728
106MP0002229_neurodegeneration1.00955869
107MP0004742_abnormal_vestibular_system1.00830572
108MP0002080_prenatal_lethality1.00656267
109MP0003943_abnormal_hepatobiliary_system0.99353064
110MP0005409_darkened_coat_color0.98556932
111MP0005394_taste/olfaction_phenotype0.98523622
112MP0005499_abnormal_olfactory_system0.98523622
113MP0002233_abnormal_nose_morphology0.97831291
114MP0006036_abnormal_mitochondrial_physio0.97227921
115MP0000313_abnormal_cell_death0.96513294
116MP0001963_abnormal_hearing_physiology0.96240041
117MP0003633_abnormal_nervous_system0.96129941
118MP0003631_nervous_system_phenotype0.95428050
119MP0000566_synostosis0.94983930
120MP0002752_abnormal_somatic_nervous0.94816078
121MP0002697_abnormal_eye_size0.93155087
122MP0002234_abnormal_pharynx_morphology0.93119716
123MP0003632_abnormal_nervous_system0.92887545
124MP0009379_abnormal_foot_pigmentation0.91451835
125MP0010386_abnormal_urinary_bladder0.87982622
126MP0005171_absent_coat_pigmentation0.86880747
127MP0001299_abnormal_eye_distance/0.86760215
128MP0001346_abnormal_lacrimal_gland0.84892016
129MP0006292_abnormal_olfactory_placode0.84435837
130MP0004858_abnormal_nervous_system0.82787428
131MP0003861_abnormal_nervous_system0.81988319
132MP0000751_myopathy0.81123152
133MP0003136_yellow_coat_color0.79214734
134MP0008872_abnormal_physiological_respon0.78217781
135MP0002069_abnormal_eating/drinking_beha0.78042832
136MP0003941_abnormal_skin_development0.76990745
137MP0003119_abnormal_digestive_system0.75314027
138MP0004085_abnormal_heartbeat0.75286975
139MP0003634_abnormal_glial_cell0.74652339
140MP0002102_abnormal_ear_morphology0.74601344
141MP0002876_abnormal_thyroid_physiology0.74570921
142MP0003315_abnormal_perineum_morphology0.73359422
143MP0002837_dystrophic_cardiac_calcinosis0.72843889
144MP0005187_abnormal_penis_morphology0.71609537
145MP0005253_abnormal_eye_physiology0.71371265
146MP0002751_abnormal_autonomic_nervous0.70525721
147MP0000013_abnormal_adipose_tissue0.69816448
148MP0004043_abnormal_pH_regulation0.69735717
149MP0001764_abnormal_homeostasis0.69482092
150MP0000026_abnormal_inner_ear0.69349507
151MP0002111_abnormal_tail_morphology0.69173437
152MP0001177_atelectasis0.69159480
153MP0005075_abnormal_melanosome_morpholog0.68788988
154MP0002086_abnormal_extraembryonic_tissu0.68782735
155MP0000358_abnormal_cell_content/0.68163445
156MP0004233_abnormal_muscle_weight0.68034864
157MP0005220_abnormal_exocrine_pancreas0.67053532
158MP0005391_vision/eye_phenotype0.66892363
159MP0004484_altered_response_of0.66420706
160MP0003385_abnormal_body_wall0.66339995
161MP0003137_abnormal_impulse_conducting0.65699028
162MP0003938_abnormal_ear_development0.65536492
163MP0002019_abnormal_tumor_incidence0.65259325
164MP0000049_abnormal_middle_ear0.65248350
165MP0001943_abnormal_respiration0.64715937
166MP0001119_abnormal_female_reproductive0.63492173
167MP0002082_postnatal_lethality0.60423841
168MP0010770_preweaning_lethality0.60423841
169MP0010769_abnormal_survival0.59225176
170MP0010768_mortality/aging0.57320919
171MP0000920_abnormal_myelination0.57047537
172MP0003698_abnormal_male_reproductive0.55132676

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.34093484
2Focal seizures (HP:0007359)5.19199855
3Atonic seizures (HP:0010819)5.13729938
4Myokymia (HP:0002411)4.86934509
5Epileptic encephalopathy (HP:0200134)4.82458561
6Febrile seizures (HP:0002373)4.59142557
7Absence seizures (HP:0002121)4.23634015
8Visual hallucinations (HP:0002367)4.16906583
9Progressive cerebellar ataxia (HP:0002073)4.08173553
10Dialeptic seizures (HP:0011146)3.85879153
11Volvulus (HP:0002580)3.71134019
12Broad-based gait (HP:0002136)3.61309331
13Generalized tonic-clonic seizures (HP:0002069)3.48057102
14Gaze-evoked nystagmus (HP:0000640)3.40710565
15Colon cancer (HP:0003003)3.20945515
16Abnormality of chromosome stability (HP:0003220)3.17370847
17Chromsome breakage (HP:0040012)3.17226539
18Hyperventilation (HP:0002883)3.03382285
19Dysdiadochokinesis (HP:0002075)2.98405241
20Truncal ataxia (HP:0002078)2.91812525
21Microvesicular hepatic steatosis (HP:0001414)2.90828305
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.86787391
23Impaired vibration sensation in the lower limbs (HP:0002166)2.86459335
24Excessive salivation (HP:0003781)2.73039464
25Drooling (HP:0002307)2.73039464
26Action tremor (HP:0002345)2.72376197
27Impaired smooth pursuit (HP:0007772)2.70135380
28Methylmalonic acidemia (HP:0002912)2.66073699
29Abnormality of the labia minora (HP:0012880)2.64917486
30Dysmetria (HP:0001310)2.61755165
31Progressive inability to walk (HP:0002505)2.59002273
32Poor eye contact (HP:0000817)2.58270429
33Urinary bladder sphincter dysfunction (HP:0002839)2.51904806
34Scanning speech (HP:0002168)2.48909794
35Hemiparesis (HP:0001269)2.45917422
36Epileptiform EEG discharges (HP:0011182)2.43380549
37Increased hepatocellular lipid droplets (HP:0006565)2.42718477
38Genetic anticipation (HP:0003743)2.41171905
39Gait imbalance (HP:0002141)2.40194442
40Amblyopia (HP:0000646)2.39960095
41Absent speech (HP:0001344)2.39918465
42Birth length less than 3rd percentile (HP:0003561)2.38081834
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.35568774
44Protruding tongue (HP:0010808)2.35442594
45Abnormality of ocular smooth pursuit (HP:0000617)2.34805887
46Termporal pattern (HP:0011008)2.34728394
47Insidious onset (HP:0003587)2.34728394
48Meckel diverticulum (HP:0002245)2.32038222
49Acute lymphatic leukemia (HP:0006721)2.31669378
50Diplopia (HP:0000651)2.30019511
51Abnormality of binocular vision (HP:0011514)2.30019511
52Abnormality of methionine metabolism (HP:0010901)2.29471421
53Hyperglycinemia (HP:0002154)2.27383059
54EEG with generalized epileptiform discharges (HP:0011198)2.26482837
55Pancreatic fibrosis (HP:0100732)2.26096663
56Depression (HP:0000716)2.24912279
57Abnormality of the ileum (HP:0001549)2.23145620
58Anxiety (HP:0000739)2.22954311
59Reticulocytopenia (HP:0001896)2.22926093
60Sloping forehead (HP:0000340)2.22534390
61Impaired social interactions (HP:0000735)2.22402848
62Abnormal social behavior (HP:0012433)2.22402848
63Macrocytic anemia (HP:0001972)2.21497422
64Medulloblastoma (HP:0002885)2.21195433
65Lipid accumulation in hepatocytes (HP:0006561)2.20640503
66Spastic gait (HP:0002064)2.19507211
67Abnormal lung lobation (HP:0002101)2.19245648
68Myelodysplasia (HP:0002863)2.19161356
69Congenital primary aphakia (HP:0007707)2.16075187
70Gonadotropin excess (HP:0000837)2.14475572
71Nephroblastoma (Wilms tumor) (HP:0002667)2.11049992
72Oligodactyly (hands) (HP:0001180)2.08845523
73Nephronophthisis (HP:0000090)2.08781048
74Hypsarrhythmia (HP:0002521)2.08312871
75Renal cortical cysts (HP:0000803)2.08188797
76Abnormal eating behavior (HP:0100738)2.08137957
77Supernumerary spleens (HP:0009799)2.07591818
78Duodenal stenosis (HP:0100867)2.06404046
79Small intestinal stenosis (HP:0012848)2.06404046
80Postural instability (HP:0002172)2.05701290
81Rhabdomyosarcoma (HP:0002859)2.05437055
82Acute myeloid leukemia (HP:0004808)2.04833301
83Abnormality of homocysteine metabolism (HP:0010919)2.04807879
84Homocystinuria (HP:0002156)2.04807879
85Acute necrotizing encephalopathy (HP:0006965)2.04416897
86Abnormality of the preputium (HP:0100587)2.04216206
87Medial flaring of the eyebrow (HP:0010747)2.03840863
88Intestinal atresia (HP:0011100)2.03204382
89Bradykinesia (HP:0002067)2.02851138
90Limb dystonia (HP:0002451)2.02080053
91Embryonal renal neoplasm (HP:0011794)2.01982975
92Urinary urgency (HP:0000012)2.01225156
93Pheochromocytoma (HP:0002666)2.01182329
94Dysmetric saccades (HP:0000641)1.99971177
95Abnormality of the corticospinal tract (HP:0002492)1.98895113
96Triphalangeal thumb (HP:0001199)1.97811606
97Neuroendocrine neoplasm (HP:0100634)1.97723079
98Pancreatic cysts (HP:0001737)1.96902678
99Genital tract atresia (HP:0001827)1.95663889
100Nephrogenic diabetes insipidus (HP:0009806)1.95174028
101Supranuclear gaze palsy (HP:0000605)1.95044948
102Increased serum pyruvate (HP:0003542)1.94991786
103Abnormal hair whorl (HP:0010721)1.94422729
104Abnormality of the vitamin B12 metabolism (HP:0004341)1.93807805
105Neoplasm of the colon (HP:0100273)1.93235081
106Specific learning disability (HP:0001328)1.93125003
107Inability to walk (HP:0002540)1.92675164
108Progressive macrocephaly (HP:0004481)1.92637788
109Papilledema (HP:0001085)1.92346467
110Dynein arm defect of respiratory motile cilia (HP:0012255)1.90611292
111Absent/shortened dynein arms (HP:0200106)1.90611292
112Abnormality of cells of the erythroid lineage (HP:0012130)1.90300974
113Abnormality of the lower motor neuron (HP:0002366)1.90277438
114Megaloblastic anemia (HP:0001889)1.90218216
115Vaginal atresia (HP:0000148)1.89837372
116Abnormality of the duodenum (HP:0002246)1.89693885
117Increased CSF lactate (HP:0002490)1.86923857
118Panhypogammaglobulinemia (HP:0003139)1.86284912
119Cerebral edema (HP:0002181)1.86259413
120Shoulder girdle muscle weakness (HP:0003547)1.85619431
121Abnormality of salivation (HP:0100755)1.84983531
122Impaired vibratory sensation (HP:0002495)1.84929744
123Abnormality of vitamin B metabolism (HP:0004340)1.84640662
124Ankle clonus (HP:0011448)1.84620222
125Acute encephalopathy (HP:0006846)1.84218289
126True hermaphroditism (HP:0010459)1.81340312
127Abnormal mitochondria in muscle tissue (HP:0008316)1.79651495
128Severe combined immunodeficiency (HP:0004430)1.79173144
129Increased nuchal translucency (HP:0010880)1.78829015
130Hyperthyroidism (HP:0000836)1.78280713
131Gait ataxia (HP:0002066)1.77521018
132Resting tremor (HP:0002322)1.77410840
133Retinal dysplasia (HP:0007973)1.77042131
134Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76765089
135Status epilepticus (HP:0002133)1.76676227
136Labial hypoplasia (HP:0000066)1.76478897
137Mitochondrial inheritance (HP:0001427)1.76464103
138Tubulointerstitial nephritis (HP:0001970)1.75408723
139Abnormality of midbrain morphology (HP:0002418)1.75163541
140Molar tooth sign on MRI (HP:0002419)1.75163541
141Gastroesophageal reflux (HP:0002020)1.75050509
142Abnormality of serum amino acid levels (HP:0003112)1.74676077
143Degeneration of the lateral corticospinal tracts (HP:0002314)1.73632250
144Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.73632250
145Glioma (HP:0009733)1.73127512
146Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.72945162
147Hemiplegia (HP:0002301)1.72548079
148Overlapping toe (HP:0001845)1.72138061
149Decreased testicular size (HP:0008734)1.71441368
150Stereotypic behavior (HP:0000733)1.71301711
151Bile duct proliferation (HP:0001408)1.70498375
152Abnormal biliary tract physiology (HP:0012439)1.70498375
153Incomplete penetrance (HP:0003829)1.69831137
154Abnormality of the renal medulla (HP:0100957)1.69550236
155Abnormality of glycolysis (HP:0004366)1.69433703
156Poor coordination (HP:0002370)1.68594860
157Clubbing of toes (HP:0100760)1.68197894
158Neoplasm of the small intestine (HP:0100833)1.67766977
159Cortical dysplasia (HP:0002539)1.67376052
160Abnormal ciliary motility (HP:0012262)1.67242411
161B lymphocytopenia (HP:0010976)1.66052145
162Hyperglycinuria (HP:0003108)1.65634722
163Mutism (HP:0002300)1.65468074
164Hypoplastic female external genitalia (HP:0012815)1.65245796
165Polyphagia (HP:0002591)1.63677391
166Blue irides (HP:0000635)1.63572883
167Abnormality of glycine metabolism (HP:0010895)1.63509859
168Abnormality of serine family amino acid metabolism (HP:0010894)1.63509859
169Hepatocellular necrosis (HP:0001404)1.63285795
170Generalized myoclonic seizures (HP:0002123)1.63229564
171Pancreatic islet-cell hyperplasia (HP:0004510)1.63172195
172Combined immunodeficiency (HP:0005387)1.62390002
173Abnormal number of erythroid precursors (HP:0012131)1.61694241
174Gastrointestinal atresia (HP:0002589)1.61052093
175Cerebral inclusion bodies (HP:0100314)1.60676711
176Short middle phalanx of the 5th finger (HP:0004220)1.59589145
177Narrow nasal bridge (HP:0000446)1.59063572
178Biliary tract neoplasm (HP:0100574)1.58694178
179Aplasia/Hypoplasia of the brainstem (HP:0007362)1.58469270
180Methylmalonic aciduria (HP:0012120)1.57414295
1813-Methylglutaconic aciduria (HP:0003535)1.56371187
182Ectopic kidney (HP:0000086)1.56073943
183Pallor (HP:0000980)1.55933747
184Cerebellar dysplasia (HP:0007033)1.55625078
185Increased serum lactate (HP:0002151)1.55608820
186Median cleft lip (HP:0000161)1.55329964

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.58035649
2EPHA43.75086026
3CASK3.41189569
4MAP3K43.33479259
5MAP2K72.66215898
6PNCK2.50049031
7MAP3K92.48945081
8BUB12.40379260
9TTK2.36322509
10BRSK22.36094002
11MARK12.33532238
12PLK42.21123436
13CAMKK22.18030160
14PBK2.15321512
15EIF2AK32.14200972
16MINK12.07823394
17WEE12.03902616
18MAP3K122.01399804
19PLK21.95705736
20TNIK1.92364308
21NTRK21.90479178
22TRIM281.90034237
23RIPK41.84518529
24MAP2K41.82689959
25TAF11.80569033
26CDK191.70485407
27MAPK131.62280864
28NUAK11.59601754
29KSR11.55487911
30PASK1.53549482
31ATR1.53174900
32PAK61.46839055
33DAPK21.46292048
34BMPR1B1.44055522
35DAPK11.43554325
36RPS6KA41.41942320
37CCNB11.38292791
38VRK11.34458822
39CAMKK11.33873770
40EIF2AK11.28449235
41OXSR11.26696669
42KSR21.26013108
43CDK51.25762051
44PRKCG1.25671891
45PRPF4B1.24578677
46ZAK1.21781326
47MST41.20064246
48PLK11.18558459
49DYRK31.16014694
50PDK21.15323881
51SIK21.15058827
52CDC71.13527052
53MAPKAPK51.11745363
54CAMK2B1.10926286
55VRK21.10644358
56CHEK21.09795820
57MAP4K21.08033661
58NTRK11.07775557
59ATM1.06005521
60GRK51.05813487
61UHMK11.05698708
62AKT31.05390225
63CDK61.03498004
64TSSK60.99705243
65CHEK10.99596903
66CAMK2A0.97725628
67LATS10.93848649
68CDK180.93432898
69CDK150.91962453
70STK38L0.90787969
71FES0.89918818
72WNK40.89442968
73NME10.89330698
74CDK140.88492140
75FGFR20.88305314
76FLT30.87275232
77STK160.85782705
78CSNK1G20.84585738
79FRK0.84453615
80ARAF0.84450669
81CAMK1G0.84116691
82CSNK1G10.82149378
83AURKB0.81320675
84STK30.80585746
85CDK11A0.79780162
86DYRK1A0.79618514
87PLK30.77426640
88RAF10.75872593
89SRPK10.74428191
90EIF2AK20.74220042
91RPS6KB20.74002874
92MKNK20.73729479
93BRSK10.73077252
94NEK10.72955599
95BCR0.71523666
96MAP3K130.71000389
97PHKG10.70471778
98PHKG20.70471778
99PINK10.70149768
100NEK60.69943165
101TGFBR10.69137787
102TYRO30.69122134
103WNK30.68205444
104BMPR20.67172408
105PRKD30.67064808
106TEC0.66883011
107CAMK2D0.66648085
108WNK10.66530969
109STK240.66505692
110BRD40.66375141
111CDK20.66124501
112MKNK10.66121699
113SGK10.66002149
114SGK2230.64789890
115SGK4940.64789890
116ACVR1B0.62911534
117CDK10.62809153
118CAMK10.62252030
119NEK20.60486211
120SGK20.60111622
121STK380.59424407
122* CSNK2A20.58339904
123FGR0.57382104
124PAK30.57197919
125STK110.57068829
126PTK2B0.56490329
127PRKDC0.56070643
128MAP3K20.55984046
129ERBB30.54087000
130CDK30.53595535
131BRAF0.53218308
132FGFR10.52850132
133CSNK1E0.52767909
134PRKCE0.52218347
135CSNK2A10.51422067
136RPS6KA30.50365214
137MAPK100.50225898
138CDK90.49592310
139CSNK1G30.48882399
140CDK70.47294952
141MAP3K100.45409209
142DYRK20.45111227
143ROCK20.43769123
144NLK0.43590583
145CDC42BPA0.43581947
146CAMK2G0.43439015
147SIK30.42812382
148ADRBK10.41896297
149ALK0.41627417
150MAP3K60.39835082
151STK390.39814059
152TNK20.39575851
153CLK10.39548326
154YES10.39179595
155PRKCB0.39159666
156SCYL20.38245156
157PRKG10.37853653
158PRKCH0.37250689
159RPS6KB10.37123658
160CSNK1A1L0.36839367
161PRKACB0.36691473
162MAP3K50.33200088

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.52603251
2Non-homologous end-joining_Homo sapiens_hsa034504.02656859
3Mismatch repair_Homo sapiens_hsa034303.75071413
4DNA replication_Homo sapiens_hsa030303.63206869
5Synaptic vesicle cycle_Homo sapiens_hsa047213.19115410
6Protein export_Homo sapiens_hsa030603.12071453
7Homologous recombination_Homo sapiens_hsa034403.05170371
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.99880551
9Long-term potentiation_Homo sapiens_hsa047202.88286323
10RNA transport_Homo sapiens_hsa030132.84857381
11GABAergic synapse_Homo sapiens_hsa047272.75526364
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.75198780
13Glutamatergic synapse_Homo sapiens_hsa047242.71631628
14Circadian entrainment_Homo sapiens_hsa047132.69397967
15Ribosome_Homo sapiens_hsa030102.61223976
16Morphine addiction_Homo sapiens_hsa050322.60789875
17Olfactory transduction_Homo sapiens_hsa047402.56251495
18Fanconi anemia pathway_Homo sapiens_hsa034602.55297751
19Nucleotide excision repair_Homo sapiens_hsa034202.51972575
20Amphetamine addiction_Homo sapiens_hsa050312.49564763
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.43220987
22Dopaminergic synapse_Homo sapiens_hsa047282.26285693
23Basal transcription factors_Homo sapiens_hsa030222.25872557
24Cell cycle_Homo sapiens_hsa041102.25455301
25Base excision repair_Homo sapiens_hsa034102.24587111
26One carbon pool by folate_Homo sapiens_hsa006702.20341141
27RNA polymerase_Homo sapiens_hsa030202.17788354
28Taste transduction_Homo sapiens_hsa047422.15668601
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14220893
30Proteasome_Homo sapiens_hsa030502.04787297
31Salivary secretion_Homo sapiens_hsa049702.02391974
32Collecting duct acid secretion_Homo sapiens_hsa049662.00579231
33Propanoate metabolism_Homo sapiens_hsa006401.99241270
34Long-term depression_Homo sapiens_hsa047301.98941456
35Serotonergic synapse_Homo sapiens_hsa047261.91418021
36Insulin secretion_Homo sapiens_hsa049111.82376473
37Cholinergic synapse_Homo sapiens_hsa047251.71218439
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70795275
39Renin secretion_Homo sapiens_hsa049241.70728387
40Calcium signaling pathway_Homo sapiens_hsa040201.68305323
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64660431
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60465026
43Gastric acid secretion_Homo sapiens_hsa049711.59465569
44Oxytocin signaling pathway_Homo sapiens_hsa049211.58838572
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.54901014
46Oxidative phosphorylation_Homo sapiens_hsa001901.47044575
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44830669
48Cocaine addiction_Homo sapiens_hsa050301.40032237
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35809762
50Purine metabolism_Homo sapiens_hsa002301.33722742
51Cardiac muscle contraction_Homo sapiens_hsa042601.33225804
52Oocyte meiosis_Homo sapiens_hsa041141.30444455
53Gap junction_Homo sapiens_hsa045401.26092442
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25968836
55Pyrimidine metabolism_Homo sapiens_hsa002401.25456377
56Vibrio cholerae infection_Homo sapiens_hsa051101.24828488
57Alzheimers disease_Homo sapiens_hsa050101.22894426
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22114684
59GnRH signaling pathway_Homo sapiens_hsa049121.21375615
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19265021
61Selenocompound metabolism_Homo sapiens_hsa004501.17116156
62Parkinsons disease_Homo sapiens_hsa050121.16365355
63Phototransduction_Homo sapiens_hsa047441.16041309
64Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11388966
65cAMP signaling pathway_Homo sapiens_hsa040241.09273329
66Axon guidance_Homo sapiens_hsa043601.09218503
67Pyruvate metabolism_Homo sapiens_hsa006201.08541364
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00162909
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00109673
70Alcoholism_Homo sapiens_hsa050340.99833589
71Type II diabetes mellitus_Homo sapiens_hsa049300.98432163
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96390131
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95496131
74Estrogen signaling pathway_Homo sapiens_hsa049150.95492175
75Huntingtons disease_Homo sapiens_hsa050160.95369523
76Melanogenesis_Homo sapiens_hsa049160.92514446
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92331573
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89481427
79Glioma_Homo sapiens_hsa052140.88863221
80ErbB signaling pathway_Homo sapiens_hsa040120.87600410
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.86962202
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86540345
83p53 signaling pathway_Homo sapiens_hsa041150.84633534
84Butanoate metabolism_Homo sapiens_hsa006500.81055373
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77782093
86Regulation of autophagy_Homo sapiens_hsa041400.77372715
87Pancreatic secretion_Homo sapiens_hsa049720.76054849
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73232110
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71870339
90Biosynthesis of amino acids_Homo sapiens_hsa012300.70471032
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70041919
92Thyroid hormone synthesis_Homo sapiens_hsa049180.67911919
93Carbon metabolism_Homo sapiens_hsa012000.67902867
94Circadian rhythm_Homo sapiens_hsa047100.67479553
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65275132
96MAPK signaling pathway_Homo sapiens_hsa040100.63752580
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.63628016
98mRNA surveillance pathway_Homo sapiens_hsa030150.63390267
99Folate biosynthesis_Homo sapiens_hsa007900.61739616
100Wnt signaling pathway_Homo sapiens_hsa043100.60207326
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58495904
102Choline metabolism in cancer_Homo sapiens_hsa052310.58017191
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57618371
104Glucagon signaling pathway_Homo sapiens_hsa049220.56112554
105Type I diabetes mellitus_Homo sapiens_hsa049400.54542193
106Dorso-ventral axis formation_Homo sapiens_hsa043200.54335297
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53936068
108Nitrogen metabolism_Homo sapiens_hsa009100.53477007
109Inositol phosphate metabolism_Homo sapiens_hsa005620.51912660
110Dilated cardiomyopathy_Homo sapiens_hsa054140.51741367
111Steroid biosynthesis_Homo sapiens_hsa001000.51534403
112Fatty acid elongation_Homo sapiens_hsa000620.50087317
113Ras signaling pathway_Homo sapiens_hsa040140.48728921
114Peroxisome_Homo sapiens_hsa041460.45216261
115mTOR signaling pathway_Homo sapiens_hsa041500.43037956
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42194205
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41986271
118Metabolic pathways_Homo sapiens_hsa011000.41816517
119Lysine degradation_Homo sapiens_hsa003100.40221108
120Hedgehog signaling pathway_Homo sapiens_hsa043400.38724395
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38411551
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38036471
123Epstein-Barr virus infection_Homo sapiens_hsa051690.37365085
124Ether lipid metabolism_Homo sapiens_hsa005650.36788391
125Rap1 signaling pathway_Homo sapiens_hsa040150.36788319
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35695229
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33337280
128N-Glycan biosynthesis_Homo sapiens_hsa005100.33030376
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32932545
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31486558
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.31392024
132TGF-beta signaling pathway_Homo sapiens_hsa043500.31313311
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30978448
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30376403
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29836636
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29690266
137Colorectal cancer_Homo sapiens_hsa052100.29572497
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29107145
139Renal cell carcinoma_Homo sapiens_hsa052110.28604495
140Basal cell carcinoma_Homo sapiens_hsa052170.28363087
141VEGF signaling pathway_Homo sapiens_hsa043700.28341732
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27600268
143Spliceosome_Homo sapiens_hsa030400.27480104
144Melanoma_Homo sapiens_hsa052180.26137395
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.26033948
146Fatty acid metabolism_Homo sapiens_hsa012120.25969282
147Non-small cell lung cancer_Homo sapiens_hsa052230.25566456
148Thyroid cancer_Homo sapiens_hsa052160.24739988
149Rheumatoid arthritis_Homo sapiens_hsa053230.23792912
150Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23573536
151Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23489356
152African trypanosomiasis_Homo sapiens_hsa051430.22186878
153Insulin signaling pathway_Homo sapiens_hsa049100.20352754
154Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19491824
155RNA degradation_Homo sapiens_hsa030180.18459041
156Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18319597
157Hippo signaling pathway_Homo sapiens_hsa043900.17106112
158Primary immunodeficiency_Homo sapiens_hsa053400.12000149
159MicroRNAs in cancer_Homo sapiens_hsa052060.11896695
160Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.07611086
161Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.07362164
162Herpes simplex infection_Homo sapiens_hsa051680.05305042

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