ZRANB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.08549858
2nuclear pore organization (GO:0006999)5.06522484
3nuclear pore complex assembly (GO:0051292)4.90849465
4DNA unwinding involved in DNA replication (GO:0006268)4.73082396
5DNA replication initiation (GO:0006270)4.60000894
6DNA strand elongation involved in DNA replication (GO:0006271)4.55087610
7mitotic chromosome condensation (GO:0007076)4.38936453
8protein localization to chromosome, centromeric region (GO:0071459)4.38829258
9kinetochore organization (GO:0051383)4.37287508
10telomere maintenance via semi-conservative replication (GO:0032201)4.37058371
11mitotic sister chromatid cohesion (GO:0007064)4.36588467
12mitotic metaphase plate congression (GO:0007080)4.36391682
13DNA strand elongation (GO:0022616)4.35751416
14mitotic sister chromatid segregation (GO:0000070)4.34246338
15DNA replication-dependent nucleosome assembly (GO:0006335)4.22458264
16DNA replication-dependent nucleosome organization (GO:0034723)4.22458264
17telomere maintenance via recombination (GO:0000722)4.21592117
18DNA replication checkpoint (GO:0000076)4.21049686
19attachment of spindle microtubules to kinetochore (GO:0008608)4.19663551
20sister chromatid segregation (GO:0000819)4.19458346
21mitotic recombination (GO:0006312)4.19386707
22mitotic nuclear envelope disassembly (GO:0007077)4.15992511
23meiotic chromosome segregation (GO:0045132)4.09569409
24metaphase plate congression (GO:0051310)4.00869040
25chromatin remodeling at centromere (GO:0031055)4.00072561
26* replication fork processing (GO:0031297)3.94425527
27CENP-A containing nucleosome assembly (GO:0034080)3.93531808
28pore complex assembly (GO:0046931)3.90830787
29nuclear envelope disassembly (GO:0051081)3.89287309
30membrane disassembly (GO:0030397)3.89287309
31DNA duplex unwinding (GO:0032508)3.75445019
32* DNA geometric change (GO:0032392)3.75445019
33regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.75403313
34DNA replication-independent nucleosome assembly (GO:0006336)3.73450682
35DNA replication-independent nucleosome organization (GO:0034724)3.73450682
36synapsis (GO:0007129)3.67919942
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.66846403
38regulation of helicase activity (GO:0051095)3.62874257
39kinetochore assembly (GO:0051382)3.62039369
40establishment of chromosome localization (GO:0051303)3.61923964
41regulation of meiosis I (GO:0060631)3.61849000
42somatic diversification of immune receptors via somatic mutation (GO:0002566)3.60373160
43somatic hypermutation of immunoglobulin genes (GO:0016446)3.60373160
44telomere maintenance via telomere lengthening (GO:0010833)3.60276469
45regulation of centrosome cycle (GO:0046605)3.58676156
46regulation of histone H3-K9 methylation (GO:0051570)3.57280954
47nucleotide-excision repair, DNA gap filling (GO:0006297)3.52973479
48regulation of DNA endoreduplication (GO:0032875)3.52687755
49regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.52624705
50regulation of spindle organization (GO:0090224)3.52188241
51histone exchange (GO:0043486)3.50488292
52regulation of centriole replication (GO:0046599)3.45684546
53regulation of double-strand break repair via homologous recombination (GO:0010569)3.44798983
54* negative regulation of DNA-dependent DNA replication (GO:2000104)3.43123329
55IMP biosynthetic process (GO:0006188)3.42307985
56regulation of nuclear cell cycle DNA replication (GO:0033262)3.41034128
57protein K6-linked ubiquitination (GO:0085020)3.40702081
58centriole replication (GO:0007099)3.40308988
59mismatch repair (GO:0006298)3.39511674
60mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.38822907
61mitochondrial respiratory chain complex I assembly (GO:0032981)3.38822907
62NADH dehydrogenase complex assembly (GO:0010257)3.38822907
63recombinational repair (GO:0000725)3.38316009
64nucleobase biosynthetic process (GO:0046112)3.37077164
65chromosome segregation (GO:0007059)3.36491913
66protein complex biogenesis (GO:0070271)3.35880527
67behavioral response to nicotine (GO:0035095)3.35732858
68double-strand break repair via homologous recombination (GO:0000724)3.35248148
69protein localization to chromosome (GO:0034502)3.33360930
70regulation of chromosome segregation (GO:0051983)3.33357976
71reciprocal meiotic recombination (GO:0007131)3.32573659
72reciprocal DNA recombination (GO:0035825)3.32573659
73resolution of meiotic recombination intermediates (GO:0000712)3.32331361
74spindle checkpoint (GO:0031577)3.32276290
75mitochondrial respiratory chain complex assembly (GO:0033108)3.32029992
76regulation of sister chromatid cohesion (GO:0007063)3.28338159
77chromatin assembly or disassembly (GO:0006333)3.27127357
78positive regulation of mitotic sister chromatid separation (GO:1901970)3.24407690
79positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.24407690
80positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.24407690
81spindle assembly checkpoint (GO:0071173)3.24342649
82negative regulation of chromosome segregation (GO:0051985)3.23191640
83* maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.23113996
84telomere maintenance (GO:0000723)3.22469388
85* DNA conformation change (GO:0071103)3.22112003
86regulation of mitotic metaphase/anaphase transition (GO:0030071)3.21344715
87translesion synthesis (GO:0019985)3.19954757
88telomere organization (GO:0032200)3.19339013
89positive regulation of chromosome segregation (GO:0051984)3.17826320
90negative regulation of sister chromatid segregation (GO:0033046)3.16767220
91negative regulation of mitotic sister chromatid separation (GO:2000816)3.16767220
92negative regulation of mitotic sister chromatid segregation (GO:0033048)3.16767220
93negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.16767220
94respiratory chain complex IV assembly (GO:0008535)3.16376424
95pre-miRNA processing (GO:0031054)3.15781181
96regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.14020651
97purine nucleobase biosynthetic process (GO:0009113)3.14001241
98nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13946934
99regulation of mitotic spindle organization (GO:0060236)3.12141498
100exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11965713
101postreplication repair (GO:0006301)3.10295603
102mitotic spindle assembly checkpoint (GO:0007094)3.10260605
103regulation of double-strand break repair (GO:2000779)3.08973037
104regulation of sister chromatid segregation (GO:0033045)3.07448050
105regulation of mitotic sister chromatid separation (GO:0010965)3.07448050
106regulation of mitotic sister chromatid segregation (GO:0033047)3.07448050
107negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07423651
108negative regulation of histone methylation (GO:0031061)3.07084335
109regulation of centrosome duplication (GO:0010824)3.06938183
110chromosome condensation (GO:0030261)3.06917738
111microtubule depolymerization (GO:0007019)3.04504780
112mitotic spindle checkpoint (GO:0071174)3.03880638
113heterochromatin organization (GO:0070828)3.02631275
114cytochrome complex assembly (GO:0017004)3.02491780
115folic acid-containing compound biosynthetic process (GO:0009396)3.01826393
116IMP metabolic process (GO:0046040)2.98209421
117response to pheromone (GO:0019236)2.97865929
118DNA double-strand break processing (GO:0000729)2.97492255
119DNA synthesis involved in DNA repair (GO:0000731)2.96666552
120piRNA metabolic process (GO:0034587)2.93387582
121nuclear envelope organization (GO:0006998)2.92442942
122regulation of mitotic spindle checkpoint (GO:1903504)2.90863869
123regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.90863869
124RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.87924421
125water-soluble vitamin biosynthetic process (GO:0042364)2.83570237
126maturation of 5.8S rRNA (GO:0000460)2.82145944
127DNA ligation (GO:0006266)2.75278071
128nonmotile primary cilium assembly (GO:0035058)2.75141971
129protein K11-linked deubiquitination (GO:0035871)2.73375496
130cellular ketone body metabolic process (GO:0046950)2.71382448
131somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.71248448
132somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.71248448
133isotype switching (GO:0045190)2.71248448
134peptidyl-histidine modification (GO:0018202)2.69154987
135DNA catabolic process, exonucleolytic (GO:0000738)2.67897124
136ubiquinone biosynthetic process (GO:0006744)2.59761358
137tryptophan catabolic process (GO:0006569)2.59726750
138indole-containing compound catabolic process (GO:0042436)2.59726750
139indolalkylamine catabolic process (GO:0046218)2.59726750
140L-fucose metabolic process (GO:0042354)2.59640708
141L-fucose catabolic process (GO:0042355)2.59640708
142fucose catabolic process (GO:0019317)2.59640708
143centrosome organization (GO:0051297)2.59375455
144ubiquinone metabolic process (GO:0006743)2.58799778
145protein-cofactor linkage (GO:0018065)2.58633644
146rRNA catabolic process (GO:0016075)2.58325121
147tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.56889258
148RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.56889258
149intraciliary transport (GO:0042073)2.56821286
150double-strand break repair (GO:0006302)2.56629280
151regulation of mitochondrial translation (GO:0070129)2.55933605
152protein polyglutamylation (GO:0018095)2.53855351
153ribosomal small subunit assembly (GO:0000028)2.53673353
154mitochondrial RNA metabolic process (GO:0000959)2.53467647
155DNA recombination (GO:0006310)2.53206826
156indolalkylamine metabolic process (GO:0006586)2.51287703
157proteasome assembly (GO:0043248)2.49544740
158male meiosis I (GO:0007141)2.48319449
159protein neddylation (GO:0045116)2.46937646
160microtubule organizing center organization (GO:0031023)2.46437612
161detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.46244933
162regulation of hexokinase activity (GO:1903299)2.45588278
163regulation of glucokinase activity (GO:0033131)2.45588278
164kynurenine metabolic process (GO:0070189)2.44754333
165somatic diversification of immunoglobulins (GO:0016445)2.43800287
166platelet dense granule organization (GO:0060155)2.43749036
167neural tube formation (GO:0001841)2.43724703
168ketone body metabolic process (GO:1902224)2.42964981
169epithelial cilium movement (GO:0003351)2.42418119
170mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.41724385
171mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.41422726
172establishment of protein localization to mitochondrial membrane (GO:0090151)2.40622866
173male meiosis (GO:0007140)2.40610065

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.86244123
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.58104029
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.58708708
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.53677308
5ZNF274_21170338_ChIP-Seq_K562_Hela3.45887563
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.81023933
7VDR_22108803_ChIP-Seq_LS180_Human2.77213933
8IGF1R_20145208_ChIP-Seq_DFB_Human2.73893994
9AR_21909140_ChIP-Seq_LNCAP_Human2.52781873
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.49394237
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46765419
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.45131683
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.44012843
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.42919162
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.42659008
16FUS_26573619_Chip-Seq_HEK293_Human2.39984985
17EWS_26573619_Chip-Seq_HEK293_Human2.38888521
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28246226
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17588604
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17186619
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12424915
22GBX2_23144817_ChIP-Seq_PC3_Human2.12391774
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10310091
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07729058
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07059822
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.05212349
27E2F7_22180533_ChIP-Seq_HELA_Human11.7844319
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99596775
29* EST1_17652178_ChIP-ChIP_JURKAT_Human1.98933104
30TAF15_26573619_Chip-Seq_HEK293_Human1.92729170
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92363974
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83381111
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81011861
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79269477
35P300_19829295_ChIP-Seq_ESCs_Human1.78705790
36XRN2_22483619_ChIP-Seq_HELA_Human1.74895055
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.71371571
38MYC_18940864_ChIP-ChIP_HL60_Human1.71255919
39VDR_23849224_ChIP-Seq_CD4+_Human1.70630013
40* ETS1_20019798_ChIP-Seq_JURKAT_Human1.70051032
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69204715
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68246503
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.67927401
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66622104
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65624580
46IRF1_19129219_ChIP-ChIP_H3396_Human1.65152056
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63606984
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62719764
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60951648
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56698489
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54952621
52EZH2_22144423_ChIP-Seq_EOC_Human1.54375933
53* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53780359
54FOXP3_21729870_ChIP-Seq_TREG_Human1.52979505
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52884065
56ER_23166858_ChIP-Seq_MCF-7_Human1.52234266
57ELK1_19687146_ChIP-ChIP_HELA_Human1.49556597
58* GABP_17652178_ChIP-ChIP_JURKAT_Human1.47726222
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46519809
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45611511
61MYC_22102868_ChIP-Seq_BL_Human1.45085124
62DCP1A_22483619_ChIP-Seq_HELA_Human1.44634334
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43568646
64TTF2_22483619_ChIP-Seq_HELA_Human1.41727241
65TFEB_21752829_ChIP-Seq_HELA_Human1.40871020
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40551946
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36875844
68CIITA_25753668_ChIP-Seq_RAJI_Human1.36139283
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34045831
70TP53_22573176_ChIP-Seq_HFKS_Human1.33900858
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33419888
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32371877
73* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32334202
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32304339
75KDM5A_27292631_Chip-Seq_BREAST_Human1.32243034
76* SRF_21415370_ChIP-Seq_HL-1_Mouse1.31958950
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31879074
78GABP_19822575_ChIP-Seq_HepG2_Human1.31831788
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30177010
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29348104
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27268375
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.24984491
83IRF8_21731497_ChIP-ChIP_J774_Mouse1.24035874
84* STAT3_23295773_ChIP-Seq_U87_Human1.23923419
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23830711
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22859179
87CBP_20019798_ChIP-Seq_JUKART_Human1.21966341
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21966341
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21632851
90RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21410192
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.19571003
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16986271
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16529462
94* TCF4_23295773_ChIP-Seq_U87_Human1.16313792
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14973398
96BCAT_22108803_ChIP-Seq_LS180_Human1.14496488
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12886633
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12447014
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11857242
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11677744
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11560026
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11460744
103SOX2_16153702_ChIP-ChIP_HESCs_Human1.10608592
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10357215
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09970302
106* EZH2_27294783_Chip-Seq_NPCs_Mouse1.09463441
107KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08759882
108SMAD4_21799915_ChIP-Seq_A2780_Human1.08716116
109SOX2_19829295_ChIP-Seq_ESCs_Human1.07391998
110NANOG_19829295_ChIP-Seq_ESCs_Human1.07391998
111AR_25329375_ChIP-Seq_VCAP_Human1.06947072
112FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06030021
113FOXA1_25329375_ChIP-Seq_VCAP_Human1.06030021
114KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05357546
115KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05357546
116KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05357546
117ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04940657
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03461093
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02809371
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02809371
121HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02699340
122* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01438118
123* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01335961
124FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01024288
125ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00052183
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99947874
127* NFE2_27457419_Chip-Seq_LIVER_Mouse0.99914032
128SMAD3_21741376_ChIP-Seq_EPCs_Human0.99522587
129* TCF4_22108803_ChIP-Seq_LS180_Human0.99351835
130RNF2_27304074_Chip-Seq_NSC_Mouse0.99228508
131TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98975603
132SPI1_23547873_ChIP-Seq_NB4_Human0.98647981
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97788669
134ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97052073
135CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96961724
136PIAS1_25552417_ChIP-Seq_VCAP_Human0.96904456
137* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96204683
138FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95507770
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94925331
140ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93272782
141* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92466091
142RUNX2_22187159_ChIP-Seq_PCA_Human0.92366775
143CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92269210
144SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92197024
145ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91829836
146YY1_21170310_ChIP-Seq_MESCs_Mouse0.91770949
147NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91428323
148* NANOG_18555785_Chip-Seq_ESCs_Mouse0.90901407
149* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90053673
150E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89497184
151HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.89009829
152GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88197760
153TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86891922
154DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85003151
155FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84719852
156ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84559220
157SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84315822
158VDR_21846776_ChIP-Seq_THP-1_Human0.81409224
159KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81386891
160KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81229653
161* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.80253125
162* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78645839
163NANOG_21062744_ChIP-ChIP_HESCs_Human0.77990932
164PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.76914348
165MYB_21317192_ChIP-Seq_ERMYB_Mouse0.76741773
166ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.74824248
167SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.74811473

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.91300521
2MP0003693_abnormal_embryo_hatching4.76235693
3MP0003111_abnormal_nucleus_morphology4.57291734
4MP0008057_abnormal_DNA_replication4.16857339
5MP0003077_abnormal_cell_cycle3.81148664
6MP0004957_abnormal_blastocyst_morpholog3.58129949
7MP0008058_abnormal_DNA_repair3.31145618
8MP0008877_abnormal_DNA_methylation2.97487905
9MP0000569_abnormal_digit_pigmentation2.95060460
10MP0008007_abnormal_cellular_replicative2.87643706
11MP0010307_abnormal_tumor_latency2.82934315
12MP0003123_paternal_imprinting2.41189049
13MP0000350_abnormal_cell_proliferation2.18917734
14MP0010352_gastrointestinal_tract_polyps2.17658657
15MP0002938_white_spotting2.14848922
16MP0003195_calcinosis2.14791938
17MP0002396_abnormal_hematopoietic_system2.07181286
18MP0001730_embryonic_growth_arrest2.03500463
19MP0002102_abnormal_ear_morphology2.02932448
20MP0009278_abnormal_bone_marrow2.02553570
21MP0006072_abnormal_retinal_apoptosis2.00779530
22MP0008932_abnormal_embryonic_tissue1.97340910
23MP0005551_abnormal_eye_electrophysiolog1.95358852
24MP0003786_premature_aging1.85308175
25MP0004147_increased_porphyrin_level1.79678906
26MP0001529_abnormal_vocalization1.79623996
27MP0005076_abnormal_cell_differentiation1.78610571
28MP0004808_abnormal_hematopoietic_stem1.78162582
29MP0003121_genomic_imprinting1.76477834
30MP0003136_yellow_coat_color1.76026261
31MP0005380_embryogenesis_phenotype1.70047176
32MP0001672_abnormal_embryogenesis/_devel1.70047176
33MP0008995_early_reproductive_senescence1.68091689
34MP0001545_abnormal_hematopoietic_system1.64115473
35MP0005397_hematopoietic_system_phenotyp1.64115473
36MP0000372_irregular_coat_pigmentation1.63953625
37MP0005253_abnormal_eye_physiology1.59476696
38MP0000490_abnormal_crypts_of1.56383304
39MP0001697_abnormal_embryo_size1.55355702
40MP0005645_abnormal_hypothalamus_physiol1.55169032
41MP0005646_abnormal_pituitary_gland1.54364395
42MP0002085_abnormal_embryonic_tissue1.53826538
43MP0003890_abnormal_embryonic-extraembry1.48063526
44MP0008875_abnormal_xenobiotic_pharmacok1.47579908
45MP0004142_abnormal_muscle_tone1.46241717
46MP0002084_abnormal_developmental_patter1.44778584
47MP0004197_abnormal_fetal_growth/weight/1.44664586
48MP0003646_muscle_fatigue1.44316610
49MP0003984_embryonic_growth_retardation1.43883935
50MP0002088_abnormal_embryonic_growth/wei1.42488898
51MP0002080_prenatal_lethality1.42090101
52MP0000313_abnormal_cell_death1.40483895
53MP0002086_abnormal_extraembryonic_tissu1.39598950
54MP0002210_abnormal_sex_determination1.36482227
55MP0005084_abnormal_gallbladder_morpholo1.35560594
56MP0001984_abnormal_olfaction1.34029074
57MP0005174_abnormal_tail_pigmentation1.32907294
58MP0003941_abnormal_skin_development1.31987604
59MP0002234_abnormal_pharynx_morphology1.31376792
60MP0002638_abnormal_pupillary_reflex1.31168521
61MP0002653_abnormal_ependyma_morphology1.30702458
62MP0002019_abnormal_tumor_incidence1.30411194
63MP0000631_abnormal_neuroendocrine_gland1.28394107
64MP0003880_abnormal_central_pattern1.26905697
65MP0000427_abnormal_hair_cycle1.25823564
66MP0003566_abnormal_cell_adhesion1.25162564
67MP0006035_abnormal_mitochondrial_morpho1.24786410
68MP0002736_abnormal_nociception_after1.24252192
69MP0003011_delayed_dark_adaptation1.23188375
70MP0006276_abnormal_autonomic_nervous1.21349272
71MP0009046_muscle_twitch1.20021085
72MP0003172_abnormal_lysosome_physiology1.18616163
73MP0000015_abnormal_ear_pigmentation1.18194252
74MP0001145_abnormal_male_reproductive1.17697922
75MP0008789_abnormal_olfactory_epithelium1.16580685
76MP0001968_abnormal_touch/_nociception1.15677386
77MP0000383_abnormal_hair_follicle1.14953642
78MP0008872_abnormal_physiological_respon1.14729915
79MP0003567_abnormal_fetal_cardiomyocyte1.11743998
80MP0003787_abnormal_imprinting1.11510781
81MP0002837_dystrophic_cardiac_calcinosis1.11082788
82MP0001986_abnormal_taste_sensitivity1.11038210
83MP0003705_abnormal_hypodermis_morpholog1.10739665
84MP0001929_abnormal_gametogenesis1.09802520
85MP0001293_anophthalmia1.08404606
86MP0003122_maternal_imprinting1.08178485
87MP0001486_abnormal_startle_reflex1.06860154
88MP0001915_intracranial_hemorrhage1.05171829
89MP0010030_abnormal_orbit_morphology1.03744019
90MP0000703_abnormal_thymus_morphology1.03739381
91MP0001485_abnormal_pinna_reflex1.02870920
92MP0004145_abnormal_muscle_electrophysio1.01186428
93MP0000689_abnormal_spleen_morphology1.00714447
94MP0000647_abnormal_sebaceous_gland1.00120087
95MP0005058_abnormal_lysosome_morphology0.99757272
96MP0002398_abnormal_bone_marrow0.98821764
97MP0005391_vision/eye_phenotype0.98744492
98MP0006036_abnormal_mitochondrial_physio0.97361705
99MP0003186_abnormal_redox_activity0.96466416
100MP0005410_abnormal_fertilization0.96214538
101MP0000858_altered_metastatic_potential0.95744561
102MP0002722_abnormal_immune_system0.95116292
103MP0005621_abnormal_cell_physiology0.95023830
104MP0009697_abnormal_copulation0.94444154
105MP0002735_abnormal_chemical_nociception0.93767794
106MP0000653_abnormal_sex_gland0.93187092
107MP0000371_diluted_coat_color0.93008823
108MP0005384_cellular_phenotype0.91784173
109MP0001286_abnormal_eye_development0.91010097
110MP0001324_abnormal_eye_pigmentation0.89803401
111MP0004215_abnormal_myocardial_fiber0.89651013
112MP0005195_abnormal_posterior_eye0.87945924
113MP0001764_abnormal_homeostasis0.87799796
114MP0005377_hearing/vestibular/ear_phenot0.87521204
115MP0003878_abnormal_ear_physiology0.87521204
116MP0002928_abnormal_bile_duct0.87347252
117MP0004043_abnormal_pH_regulation0.87152744
118MP0002751_abnormal_autonomic_nervous0.87057973
119MP0009745_abnormal_behavioral_response0.86577269
120MP0002272_abnormal_nervous_system0.86496091
121MP0003448_altered_tumor_morphology0.85907935
122MP0002163_abnormal_gland_morphology0.84621498
123MP0002233_abnormal_nose_morphology0.84581834
124MP0001835_abnormal_antigen_presentation0.84070391
125MP0005187_abnormal_penis_morphology0.83492930
126MP0009703_decreased_birth_body0.82591144
127MP0002557_abnormal_social/conspecific_i0.82496952
128MP0004742_abnormal_vestibular_system0.80620911
129MP0002075_abnormal_coat/hair_pigmentati0.80508258
130MP0005075_abnormal_melanosome_morpholog0.80489434
131MP0000516_abnormal_urinary_system0.79663462
132MP0005367_renal/urinary_system_phenotyp0.79663462
133MP0003943_abnormal_hepatobiliary_system0.79147139
134MP0006292_abnormal_olfactory_placode0.78710521
135MP0004233_abnormal_muscle_weight0.77767769
136MP0005394_taste/olfaction_phenotype0.77257909
137MP0009333_abnormal_splenocyte_physiolog0.75921950
138MP0001119_abnormal_female_reproductive0.74691926
139MP0005023_abnormal_wound_healing0.73565089
140MP0002429_abnormal_blood_cell0.73324334
141MP0003718_maternal_effect0.71837591
142MP0002452_abnormal_antigen_presenting0.71423927
143MP0003315_abnormal_perineum_morphology0.71160781
144MP0003698_abnormal_male_reproductive0.68198727
145MP0009672_abnormal_birth_weight0.68122397
146MP0005257_abnormal_intraocular_pressure0.68118052
147MP0004133_heterotaxia0.67679913
148MP0004264_abnormal_extraembryonic_tissu0.67451395
149MP0003937_abnormal_limbs/digits/tail_de0.66906600
150MP0002095_abnormal_skin_pigmentation0.66631823
151MP0003828_pulmonary_edema0.65652862
152MP0002111_abnormal_tail_morphology0.65493948
153MP0000716_abnormal_immune_system0.64403560
154MP0000428_abnormal_craniofacial_morphol0.64354547
155MP0001800_abnormal_humoral_immune0.64248727
156MP0002006_tumorigenesis0.62523800
157MP0002092_abnormal_eye_morphology0.62067115
158MP0000432_abnormal_head_morphology0.61377729
159MP0003119_abnormal_digestive_system0.61338498
160MP0005389_reproductive_system_phenotype0.60712269
161MP0002009_preneoplasia0.60039334
162MP0001186_pigmentation_phenotype0.57297425
163MP0003436_decreased_susceptibility_to0.56960415
164MP0000358_abnormal_cell_content/0.55971538
165MP0002420_abnormal_adaptive_immunity0.55112687
166MP0002160_abnormal_reproductive_system0.55081894

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.30697270
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.18494341
3Agnosia (HP:0010524)4.82940124
4Birth length less than 3rd percentile (HP:0003561)4.23086966
5Abnormality of chromosome stability (HP:0003220)3.89151376
6Ependymoma (HP:0002888)3.86803056
7Pancreatic cysts (HP:0001737)3.72412170
8True hermaphroditism (HP:0010459)3.69754056
9Pancreatic fibrosis (HP:0100732)3.58289234
10Meckel diverticulum (HP:0002245)3.44142003
11Volvulus (HP:0002580)3.43188498
12Abnormality of the ileum (HP:0001549)3.40962938
13Molar tooth sign on MRI (HP:0002419)3.36446300
14Abnormality of midbrain morphology (HP:0002418)3.36446300
15Abnormality of the preputium (HP:0100587)3.35246651
16Impulsivity (HP:0100710)3.32936188
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.29436295
18Abnormality of the labia minora (HP:0012880)3.26974888
19Ectopic kidney (HP:0000086)3.19870382
20Nephronophthisis (HP:0000090)3.13366933
21Prostate neoplasm (HP:0100787)3.07983357
22Patellar aplasia (HP:0006443)3.02956715
23Medulloblastoma (HP:0002885)2.98912368
24Medial flaring of the eyebrow (HP:0010747)2.98338561
25Colon cancer (HP:0003003)2.93981847
26Myelodysplasia (HP:0002863)2.93274110
27Small intestinal stenosis (HP:0012848)2.90379169
28Duodenal stenosis (HP:0100867)2.90379169
29Chronic hepatic failure (HP:0100626)2.89747367
30Selective tooth agenesis (HP:0001592)2.89321112
31Aplasia/Hypoplasia of the patella (HP:0006498)2.84724148
32Breast hypoplasia (HP:0003187)2.83121910
33Astrocytoma (HP:0009592)2.79939389
34Abnormality of the astrocytes (HP:0100707)2.79939389
35Urethral obstruction (HP:0000796)2.78138017
36Facial hemangioma (HP:0000329)2.74092615
37Reticulocytopenia (HP:0001896)2.73260284
38Absent radius (HP:0003974)2.71616620
39Rhabdomyosarcoma (HP:0002859)2.68113979
40Glioma (HP:0009733)2.67841293
41Sloping forehead (HP:0000340)2.64968876
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.64887548
43Abnormality of alanine metabolism (HP:0010916)2.64887548
44Hyperalaninemia (HP:0003348)2.64887548
45Abnormality of the renal medulla (HP:0100957)2.63058638
46Duplicated collecting system (HP:0000081)2.59252008
47Abnormality of the renal collecting system (HP:0004742)2.58940360
48Acute necrotizing encephalopathy (HP:0006965)2.57677951
49Acute encephalopathy (HP:0006846)2.55610686
50Absent forearm bone (HP:0003953)2.54883939
51Aplasia involving forearm bones (HP:0009822)2.54883939
52Abnormality of the renal cortex (HP:0011035)2.53886478
53Increased nuchal translucency (HP:0010880)2.53618851
54Supernumerary spleens (HP:0009799)2.52660225
55Abnormality of the carotid arteries (HP:0005344)2.49503658
56Absent thumb (HP:0009777)2.49148916
57Bone marrow hypocellularity (HP:0005528)2.45814621
58Prominent nose (HP:0000448)2.44526508
59Congenital primary aphakia (HP:0007707)2.42559956
60Gait imbalance (HP:0002141)2.39523824
61Aplasia/Hypoplasia of the tongue (HP:0010295)2.37903812
62Abnormality of the duodenum (HP:0002246)2.36991346
63Increased CSF lactate (HP:0002490)2.36959708
64Aplasia/Hypoplasia of the tibia (HP:0005772)2.36778556
65Bile duct proliferation (HP:0001408)2.36429419
66Abnormal biliary tract physiology (HP:0012439)2.36429419
67Neoplasm of the oral cavity (HP:0100649)2.35319550
68Cafe-au-lait spot (HP:0000957)2.31921562
69Disinhibition (HP:0000734)2.30056356
70Clubbing of toes (HP:0100760)2.29607959
71High pitched voice (HP:0001620)2.29586986
72Anencephaly (HP:0002323)2.28120069
73Nephroblastoma (Wilms tumor) (HP:0002667)2.28105556
74Postaxial foot polydactyly (HP:0001830)2.27678593
75Tracheoesophageal fistula (HP:0002575)2.27439493
76Progressive macrocephaly (HP:0004481)2.24025247
77Recurrent abscess formation (HP:0002722)2.22215480
78Degeneration of anterior horn cells (HP:0002398)2.21903006
79Abnormality of the anterior horn cell (HP:0006802)2.21903006
80Mitochondrial inheritance (HP:0001427)2.21854058
81Cystic liver disease (HP:0006706)2.21806003
82Pendular nystagmus (HP:0012043)2.21014421
83Renal cortical cysts (HP:0000803)2.20131110
84Nephrogenic diabetes insipidus (HP:0009806)2.18377850
85Abnormal mitochondria in muscle tissue (HP:0008316)2.17488176
86Hyperglycinemia (HP:0002154)2.17087050
87Genital tract atresia (HP:0001827)2.16999290
88Upper motor neuron abnormality (HP:0002127)2.16992559
89Embryonal renal neoplasm (HP:0011794)2.12551585
90Abnormality of the pons (HP:0007361)2.11671354
91Abnormality of DNA repair (HP:0003254)2.11457092
92Sclerocornea (HP:0000647)2.10546236
93Abnormal lung lobation (HP:0002101)2.09912636
94Proximal placement of thumb (HP:0009623)2.09700891
95Attenuation of retinal blood vessels (HP:0007843)2.09395279
96Male pseudohermaphroditism (HP:0000037)2.08865628
97Vaginal atresia (HP:0000148)2.07317199
98Lipid accumulation in hepatocytes (HP:0006561)2.06460003
99Abolished electroretinogram (ERG) (HP:0000550)2.05994330
100Hepatocellular necrosis (HP:0001404)2.03602160
101Intestinal atresia (HP:0011100)2.02482509
102Neoplasm of the pancreas (HP:0002894)2.00732885
103Congenital stationary night blindness (HP:0007642)2.00433568
104Hyperglycinuria (HP:0003108)2.00253855
105Hepatic necrosis (HP:0002605)1.99681698
106Personality changes (HP:0000751)1.99420806
107Poor coordination (HP:0002370)1.98758827
108Abnormal number of erythroid precursors (HP:0012131)1.97503477
109Intestinal fistula (HP:0100819)1.97350029
110Short tibia (HP:0005736)1.97238031
111Deviation of the thumb (HP:0009603)1.96990707
112Short thumb (HP:0009778)1.95853229
113Hypoplasia of the pons (HP:0012110)1.95537321
114Type II lissencephaly (HP:0007260)1.93923571
115Increased hepatocellular lipid droplets (HP:0006565)1.93758883
116Premature graying of hair (HP:0002216)1.93756299
117Amaurosis fugax (HP:0100576)1.93067102
118Oligodactyly (hands) (HP:0001180)1.92760778
119Abnormality of the fingertips (HP:0001211)1.92610307
120Astigmatism (HP:0000483)1.91969999
121Preaxial hand polydactyly (HP:0001177)1.91872549
122Dandy-Walker malformation (HP:0001305)1.88812795
123Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88416868
124Tubular atrophy (HP:0000092)1.88130015
125Neoplasm of striated muscle (HP:0009728)1.86992584
126Tubulointerstitial nephritis (HP:0001970)1.84881301
127Leukopenia (HP:0001882)1.84343235
128Arteriovenous malformation (HP:0100026)1.84276587
129Triphalangeal thumb (HP:0001199)1.83057292
130Atresia of the external auditory canal (HP:0000413)1.81239169
131Capillary hemangiomas (HP:0005306)1.80550385
132Oral leukoplakia (HP:0002745)1.80431549
133Abnormality of cells of the erythroid lineage (HP:0012130)1.80059366
134Abnormal number of incisors (HP:0011064)1.79031196
135Abnormality of serum amino acid levels (HP:0003112)1.79014474
136Rectovaginal fistula (HP:0000143)1.78904029
137Rectal fistula (HP:0100590)1.78904029
138Biliary tract neoplasm (HP:0100574)1.78675521
139Basal cell carcinoma (HP:0002671)1.78156775
140Aplasia/hypoplasia of the humerus (HP:0006507)1.77372680
141Skull defect (HP:0001362)1.77351264
142Horseshoe kidney (HP:0000085)1.76995587
143Aplasia/Hypoplasia of the sternum (HP:0006714)1.76380657
144Postaxial hand polydactyly (HP:0001162)1.76182529
145Abnormality of glycine metabolism (HP:0010895)1.75726560
146Abnormality of serine family amino acid metabolism (HP:0010894)1.75726560
147Cerebral edema (HP:0002181)1.75392643
148Heterotopia (HP:0002282)1.74730569
149Congenital hepatic fibrosis (HP:0002612)1.74728444
150Rib fusion (HP:0000902)1.74430261
151Oligohydramnios (HP:0001562)1.73356933
152Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72582030
153Short 4th metacarpal (HP:0010044)1.72582030
154Lymphoma (HP:0002665)1.72127693
155Increased serum lactate (HP:0002151)1.72087768
156Cerebellar dysplasia (HP:0007033)1.71272062
157Furrowed tongue (HP:0000221)1.71128089
158Long eyelashes (HP:0000527)1.71032697
159Abdominal situs inversus (HP:0003363)1.70563798
160Abnormality of abdominal situs (HP:0011620)1.70563798
161Gastrointestinal carcinoma (HP:0002672)1.70319191
162Malignant gastrointestinal tract tumors (HP:0006749)1.70319191
163Lip pit (HP:0100267)1.68977059
164Abnormality of chromosome segregation (HP:0002916)1.68394708
165Recurrent bacterial skin infections (HP:0005406)1.66023995
166Short humerus (HP:0005792)1.65754800
167Squamous cell carcinoma (HP:0002860)1.64976255
168Carpal bone hypoplasia (HP:0001498)1.64679656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.96230239
2WEE13.94376835
3FRK3.91744538
4NEK23.36249310
5CDK123.30326665
6BMPR1B3.27882170
7BUB13.23812478
8TTK3.15364776
9NUAK12.62015719
10MAP4K22.44935898
11WNK32.40190446
12EIF2AK12.39543453
13NEK12.23185422
14ATR2.22432069
15ZAK2.18838303
16PLK12.16584835
17SRPK12.07895302
18ACVR1B2.04496917
19PLK42.01685652
20INSRR1.96909731
21PASK1.89318711
22CHEK21.87999722
23AURKB1.84402842
24ADRBK21.80540681
25CCNB11.79143518
26MAP3K41.77438808
27STK41.70968049
28WNK41.70755591
29TRIM281.62328649
30VRK21.60951778
31CDK71.60455154
32TSSK61.60121810
33PLK31.60042320
34BRSK21.58112396
35MKNK11.54248537
36BRD41.54229931
37RPS6KA41.52123603
38CDK41.50255563
39TNIK1.45230076
40GRK11.43422776
41NME21.41516438
42CDK61.40945701
43CHEK11.40919225
44PINK11.38265855
45MAP3K81.34532121
46DYRK31.33571660
47VRK11.28907071
48ATM1.28261553
49TAF11.27705369
50RPS6KB21.26125198
51STK101.23639846
52STK31.20822282
53PNCK1.17464055
54BCKDK1.14369749
55TLK11.11762945
56CASK1.11072901
57AURKA1.10844962
58DYRK21.10440041
59MELK1.09654313
60SCYL21.09245105
61MKNK21.08256546
62MST41.07103828
63PIM11.06029384
64MAPK131.05784120
65CDK21.03079131
66BRSK11.02545017
67TGFBR10.99287409
68STK390.97435406
69OXSR10.95592913
70KIT0.94451102
71CDK80.92301094
72NME10.91556682
73TESK20.91108939
74PAK40.88816230
75PKN20.87637809
76CDK190.85594976
77EIF2AK20.83981939
78CSNK1G10.83526296
79PDK20.81935835
80CDK10.81280132
81MAP2K70.80881839
82CSNK1G20.79854463
83NEK90.79630483
84STK160.79499932
85EPHA20.78439026
86FLT30.77073334
87EIF2AK30.72683693
88CSF1R0.71501822
89TAOK20.70858404
90EEF2K0.70719262
91CSNK1G30.69140625
92ADRBK10.65830599
93MTOR0.63884705
94PRKCG0.63723003
95CSNK2A20.63532945
96STK38L0.63166963
97TAOK30.59377874
98MAP4K10.59274175
99MAP2K30.59142075
100OBSCN0.59057311
101DAPK10.58526896
102PRKCE0.58379541
103TTN0.57848436
104PLK20.57410581
105ERBB30.57291522
106PAK30.55805906
107CLK10.55770378
108PRKDC0.55329385
109YES10.55155847
110CSNK1A1L0.54777099
111CSNK2A10.54402813
112BCR0.52484820
113LATS10.52273041
114CDK30.51050240
115CAMK1D0.50398270
116MAP3K100.48385124
117ALK0.48100824
118CAMK1G0.46085272
119CDK90.45826077
120RPS6KA50.45227038
121FGFR20.44892185
122MUSK0.44077666
123MAPK140.43745214
124PIK3CA0.43595479
125PBK0.42919117
126TIE10.40971373
127MAPKAPK50.40648601
128CSNK1D0.40142107
129AKT20.39439376
130PRKACB0.37607314
131PAK10.36839556
132AKT10.35190010
133AKT30.33796909
134PKN10.32984613
135PIK3CG0.32102828
136PDK40.31788390
137PDK30.31788390
138CHUK0.31553827
139CSNK1A10.31444612
140TEC0.31380044
141TXK0.31288695
142CSNK1E0.31235945
143RIPK40.30107675
144GSK3B0.28616041
145GRK60.28475082
146MAPK10.28037125
147LYN0.27465997
148FGR0.26333977
149BRAF0.25864941
150BTK0.25259917
151TRPM70.25217805

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.08256349
2Mismatch repair_Homo sapiens_hsa034304.90160772
3Homologous recombination_Homo sapiens_hsa034403.41115998
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.26069426
5Cell cycle_Homo sapiens_hsa041103.19181349
6Base excision repair_Homo sapiens_hsa034103.16594007
7RNA transport_Homo sapiens_hsa030132.98392174
8Nucleotide excision repair_Homo sapiens_hsa034202.90474562
9Spliceosome_Homo sapiens_hsa030402.81961999
10Fanconi anemia pathway_Homo sapiens_hsa034602.77048742
11One carbon pool by folate_Homo sapiens_hsa006702.71362700
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.51516626
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34763492
14Non-homologous end-joining_Homo sapiens_hsa034502.24981553
15Oxidative phosphorylation_Homo sapiens_hsa001902.24570947
16Protein export_Homo sapiens_hsa030602.20399817
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.06657338
18Butanoate metabolism_Homo sapiens_hsa006502.03057435
19RNA polymerase_Homo sapiens_hsa030201.93368295
20Propanoate metabolism_Homo sapiens_hsa006401.93242686
21Parkinsons disease_Homo sapiens_hsa050121.89347158
22Pyrimidine metabolism_Homo sapiens_hsa002401.79454632
23RNA degradation_Homo sapiens_hsa030181.79437968
24mRNA surveillance pathway_Homo sapiens_hsa030151.77869938
25p53 signaling pathway_Homo sapiens_hsa041151.71533515
26Phototransduction_Homo sapiens_hsa047441.71440655
27Basal transcription factors_Homo sapiens_hsa030221.70511599
28Systemic lupus erythematosus_Homo sapiens_hsa053221.67582663
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67094300
30Proteasome_Homo sapiens_hsa030501.66942272
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62374485
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58528387
33Linoleic acid metabolism_Homo sapiens_hsa005911.51816663
34Nitrogen metabolism_Homo sapiens_hsa009101.49558300
35Huntingtons disease_Homo sapiens_hsa050161.47817099
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.41054138
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40752106
38Ribosome_Homo sapiens_hsa030101.33935915
39Caffeine metabolism_Homo sapiens_hsa002321.32808311
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.32391288
41Steroid biosynthesis_Homo sapiens_hsa001001.29592647
42Viral carcinogenesis_Homo sapiens_hsa052031.28010175
43Epstein-Barr virus infection_Homo sapiens_hsa051691.25845143
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25027722
45Tryptophan metabolism_Homo sapiens_hsa003801.19983657
46Peroxisome_Homo sapiens_hsa041461.19746580
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18737761
48Herpes simplex infection_Homo sapiens_hsa051681.16844785
49Oocyte meiosis_Homo sapiens_hsa041141.15113598
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13021735
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06908610
52Alzheimers disease_Homo sapiens_hsa050101.05601760
53Olfactory transduction_Homo sapiens_hsa047401.04952156
54Ether lipid metabolism_Homo sapiens_hsa005651.04734397
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02749755
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.00044710
57MicroRNAs in cancer_Homo sapiens_hsa052060.98450936
58HTLV-I infection_Homo sapiens_hsa051660.98441481
59Antigen processing and presentation_Homo sapiens_hsa046120.92303455
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.90631074
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.87943012
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87555801
63Legionellosis_Homo sapiens_hsa051340.87476423
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87233895
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86947496
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86652325
67Nicotine addiction_Homo sapiens_hsa050330.86552671
68Cardiac muscle contraction_Homo sapiens_hsa042600.85323790
69Purine metabolism_Homo sapiens_hsa002300.83623715
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82731834
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.82695666
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81260686
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80892294
74Metabolic pathways_Homo sapiens_hsa011000.80017429
75Small cell lung cancer_Homo sapiens_hsa052220.79594569
76Fatty acid elongation_Homo sapiens_hsa000620.75168585
77Apoptosis_Homo sapiens_hsa042100.75075949
78Chemical carcinogenesis_Homo sapiens_hsa052040.74718764
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73676058
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73128890
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72509329
82Vitamin digestion and absorption_Homo sapiens_hsa049770.71127841
83Fatty acid metabolism_Homo sapiens_hsa012120.70809677
84Pyruvate metabolism_Homo sapiens_hsa006200.69379433
85Fat digestion and absorption_Homo sapiens_hsa049750.68300750
86Colorectal cancer_Homo sapiens_hsa052100.67045202
87Regulation of autophagy_Homo sapiens_hsa041400.66669081
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66311530
89Shigellosis_Homo sapiens_hsa051310.66243580
90Influenza A_Homo sapiens_hsa051640.64026526
91Other glycan degradation_Homo sapiens_hsa005110.63763808
92Chronic myeloid leukemia_Homo sapiens_hsa052200.63382617
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.63270517
94Taste transduction_Homo sapiens_hsa047420.61804843
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61741654
96Leishmaniasis_Homo sapiens_hsa051400.61669952
97Retinol metabolism_Homo sapiens_hsa008300.60540308
98Notch signaling pathway_Homo sapiens_hsa043300.60237094
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60077306
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59618185
101Hepatitis B_Homo sapiens_hsa051610.59402316
102Fatty acid degradation_Homo sapiens_hsa000710.59193979
103Glutathione metabolism_Homo sapiens_hsa004800.57589700
104beta-Alanine metabolism_Homo sapiens_hsa004100.57486688
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55860133
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55177534
107Measles_Homo sapiens_hsa051620.55113885
108Lysine degradation_Homo sapiens_hsa003100.54233548
109TGF-beta signaling pathway_Homo sapiens_hsa043500.52003916
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51924401
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51157913
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50297498
113B cell receptor signaling pathway_Homo sapiens_hsa046620.47916876
114Phagosome_Homo sapiens_hsa041450.47601452
115Arachidonic acid metabolism_Homo sapiens_hsa005900.47412615
116Pentose phosphate pathway_Homo sapiens_hsa000300.47001255
117Folate biosynthesis_Homo sapiens_hsa007900.46700556
118Lysosome_Homo sapiens_hsa041420.46597309
119Viral myocarditis_Homo sapiens_hsa054160.46518865
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46476597
121Hippo signaling pathway_Homo sapiens_hsa043900.45754591
122Selenocompound metabolism_Homo sapiens_hsa004500.45618569
123Alcoholism_Homo sapiens_hsa050340.45514795
124Adherens junction_Homo sapiens_hsa045200.45421790
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44609171
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.44081797
127ABC transporters_Homo sapiens_hsa020100.43883012
128Pancreatic cancer_Homo sapiens_hsa052120.43852294
129Tuberculosis_Homo sapiens_hsa051520.42779157
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42361438
131Osteoclast differentiation_Homo sapiens_hsa043800.42349403
132Hedgehog signaling pathway_Homo sapiens_hsa043400.41968405
133HIF-1 signaling pathway_Homo sapiens_hsa040660.41836673
134Thyroid cancer_Homo sapiens_hsa052160.40996512
135Arginine and proline metabolism_Homo sapiens_hsa003300.40231476
136Basal cell carcinoma_Homo sapiens_hsa052170.39866997
137Glycerolipid metabolism_Homo sapiens_hsa005610.38220705
138Prostate cancer_Homo sapiens_hsa052150.37650771
139Biosynthesis of amino acids_Homo sapiens_hsa012300.37371494
140Bladder cancer_Homo sapiens_hsa052190.35754669
141mTOR signaling pathway_Homo sapiens_hsa041500.33998024
142Pathways in cancer_Homo sapiens_hsa052000.31445096
143RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31228534
144Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30778183
145Hematopoietic cell lineage_Homo sapiens_hsa046400.30384535
146Sulfur relay system_Homo sapiens_hsa041220.29373754
147Non-small cell lung cancer_Homo sapiens_hsa052230.28793602
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.28372475
149Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28279494
150FoxO signaling pathway_Homo sapiens_hsa040680.28089042
151Primary immunodeficiency_Homo sapiens_hsa053400.28069835
1522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25321804
153Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24651356
154Serotonergic synapse_Homo sapiens_hsa047260.24487103
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23754440
156Morphine addiction_Homo sapiens_hsa050320.23677154
157Pertussis_Homo sapiens_hsa051330.23611341
158Proteoglycans in cancer_Homo sapiens_hsa052050.22718573
159Toxoplasmosis_Homo sapiens_hsa051450.22381415
160Vitamin B6 metabolism_Homo sapiens_hsa007500.21475998
161Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21152277
162Melanoma_Homo sapiens_hsa052180.20005233
163Acute myeloid leukemia_Homo sapiens_hsa052210.20004642
164Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18196788
165Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18116230
166Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18035067
167Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17677315

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