ZRSR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1limb bud formation (GO:0060174)6.00963155
2neural tube formation (GO:0001841)5.98830217
3axon ensheathment in central nervous system (GO:0032291)5.68489447
4central nervous system myelination (GO:0022010)5.68489447
5glial cell proliferation (GO:0014009)5.32862393
6kidney morphogenesis (GO:0060993)5.32538362
7protein localization to cilium (GO:0061512)4.98752930
8negative regulation of translation, ncRNA-mediated (GO:0040033)4.96716265
9regulation of translation, ncRNA-mediated (GO:0045974)4.96716265
10negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.96716265
11regulation of meiosis I (GO:0060631)4.66303040
12adaptation of signaling pathway (GO:0023058)4.55013103
13DNA damage response, detection of DNA damage (GO:0042769)4.42722232
14synaptic vesicle maturation (GO:0016188)4.34246320
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.32470245
16regulation of short-term neuronal synaptic plasticity (GO:0048172)4.29131538
17synaptic vesicle exocytosis (GO:0016079)4.24760788
18neuronal action potential propagation (GO:0019227)4.19128241
19neuron cell-cell adhesion (GO:0007158)4.15068719
20cornea development in camera-type eye (GO:0061303)4.14532814
21positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.13774340
22ubiquinone metabolic process (GO:0006743)4.03079949
23somite development (GO:0061053)3.99810704
24ubiquinone biosynthetic process (GO:0006744)3.98565737
25vocalization behavior (GO:0071625)3.93493259
26respiratory chain complex IV assembly (GO:0008535)3.90458901
27glutamate secretion (GO:0014047)3.87002145
28locomotory exploration behavior (GO:0035641)3.86015720
29regulation of synaptic vesicle exocytosis (GO:2000300)3.84357935
30regulation of Rac GTPase activity (GO:0032314)3.83634906
31protein localization to synapse (GO:0035418)3.81430367
32protein K11-linked deubiquitination (GO:0035871)3.80087776
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.78352783
34NADH dehydrogenase complex assembly (GO:0010257)3.78352783
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.78352783
36regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.77033036
37sympathetic nervous system development (GO:0048485)3.64724656
38presynaptic membrane assembly (GO:0097105)3.63327103
39pyrimidine nucleobase catabolic process (GO:0006208)3.61152009
40ionotropic glutamate receptor signaling pathway (GO:0035235)3.60686958
41presynaptic membrane organization (GO:0097090)3.56727091
42gamma-aminobutyric acid transport (GO:0015812)3.51900122
43L-amino acid import (GO:0043092)3.49124547
44regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.48969270
45transmission of nerve impulse (GO:0019226)3.43728029
46embryonic epithelial tube formation (GO:0001838)3.42321085
47regulation of male gonad development (GO:2000018)3.38865920
48olfactory bulb development (GO:0021772)3.38304570
49protein complex biogenesis (GO:0070271)3.38005457
50negative regulation of neurotransmitter transport (GO:0051589)3.37375739
51positive regulation of mRNA processing (GO:0050685)3.37031333
52gamma-aminobutyric acid signaling pathway (GO:0007214)3.36909857
53neurotransmitter secretion (GO:0007269)3.35864225
54regulation of glutamate receptor signaling pathway (GO:1900449)3.34309840
55cardiac ventricle formation (GO:0003211)3.33501323
56regulation of synaptic vesicle transport (GO:1902803)3.33249931
57myelination (GO:0042552)3.30663197
58spinal cord motor neuron differentiation (GO:0021522)3.29439463
59negative regulation of synaptic transmission, GABAergic (GO:0032229)3.29127924
60cilium morphogenesis (GO:0060271)3.27824097
61ensheathment of neurons (GO:0007272)3.27512876
62axon ensheathment (GO:0008366)3.27512876
63fatty acid elongation (GO:0030497)3.26697153
64DNA integration (GO:0015074)3.26406551
65mating behavior (GO:0007617)3.26325731
66peristalsis (GO:0030432)3.26280505
67detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.24177726
68quinone biosynthetic process (GO:1901663)3.21708230
69regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.21638229
70nonmotile primary cilium assembly (GO:0035058)3.20036771
71positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.19780177
72mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.19780177
73DNA deamination (GO:0045006)3.19487391
74glutamate receptor signaling pathway (GO:0007215)3.17808784
75regulation of neuronal synaptic plasticity (GO:0048168)3.17465327
76epithelial tube formation (GO:0072175)3.16839292
77intraciliary transport (GO:0042073)3.16579287
78long-chain fatty acid biosynthetic process (GO:0042759)3.16071764
79water-soluble vitamin biosynthetic process (GO:0042364)3.14698117
80adult walking behavior (GO:0007628)3.14557118
81nucleobase catabolic process (GO:0046113)3.12042546
82replication fork processing (GO:0031297)3.10533938
83negative regulation of neurotransmitter secretion (GO:0046929)3.09091483
84membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08872527
85neurotransmitter-gated ion channel clustering (GO:0072578)3.08767026
86neuron recognition (GO:0008038)3.08394490
87neuron-neuron synaptic transmission (GO:0007270)3.07503990
88positive regulation of meiosis (GO:0045836)3.07495231
89mitochondrial respiratory chain complex assembly (GO:0033108)3.06711605
90neurotransmitter transport (GO:0006836)3.05717555
91synaptic transmission, glutamatergic (GO:0035249)3.04746426
92cytochrome complex assembly (GO:0017004)3.04514324
93exploration behavior (GO:0035640)3.04104997
94behavioral response to nicotine (GO:0035095)3.03992687
95photoreceptor cell maintenance (GO:0045494)3.03890742
96dendritic spine morphogenesis (GO:0060997)3.03778077
97spinal cord development (GO:0021510)3.02672761
98cerebellar Purkinje cell differentiation (GO:0021702)3.02610939
99regulation of excitatory postsynaptic membrane potential (GO:0060079)3.01088848
100cardiac chamber formation (GO:0003207)3.00177056
101long-term memory (GO:0007616)2.98861656
102cerebellar granule cell differentiation (GO:0021707)2.97808240
103negative regulation of smooth muscle cell differentiation (GO:0051151)2.97664791
104positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96425452
105germ cell migration (GO:0008354)2.95532454
106regulation of long-term neuronal synaptic plasticity (GO:0048169)2.95247021
107regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.94554406
108regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.91670597
109cardiac right ventricle morphogenesis (GO:0003215)2.90510659
110positive regulation of membrane potential (GO:0045838)2.90258801
111neuromuscular process controlling posture (GO:0050884)2.90077834
112layer formation in cerebral cortex (GO:0021819)2.89806334
113central nervous system projection neuron axonogenesis (GO:0021952)2.89408294
114establishment of mitochondrion localization (GO:0051654)2.88555059
115regulation of postsynaptic membrane potential (GO:0060078)2.88327270
116epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.87891544
117neuronal ion channel clustering (GO:0045161)2.87638208
118response to methylmercury (GO:0051597)2.87213490
119positive regulation of meiotic cell cycle (GO:0051446)2.86139871
120cellular potassium ion homeostasis (GO:0030007)2.84442545
121neuron remodeling (GO:0016322)2.83168157
122regulation of cilium movement (GO:0003352)2.82342686
123platelet dense granule organization (GO:0060155)2.81604113
124regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.80129927
125regulation of neurotransmitter levels (GO:0001505)2.80027024
126short-term memory (GO:0007614)2.80001285
127DNA double-strand break processing (GO:0000729)2.79652971
128regulation of dendritic spine morphogenesis (GO:0061001)2.79320007
129establishment of protein localization to mitochondrial membrane (GO:0090151)2.79146126
130indolalkylamine metabolic process (GO:0006586)2.78671501
131epithelial cilium movement (GO:0003351)2.77814063
132heparin biosynthetic process (GO:0030210)2.76664331
133heparin metabolic process (GO:0030202)2.76664331
134dendrite morphogenesis (GO:0048813)2.76524268
135cilium assembly (GO:0042384)2.76285845
136regulation of vesicle fusion (GO:0031338)2.75874083
137glycine transport (GO:0015816)2.73963825
138long-term synaptic potentiation (GO:0060291)2.73649327
139positive regulation of synaptic transmission, GABAergic (GO:0032230)2.73524030
140cytoplasmic mRNA processing body assembly (GO:0033962)2.72771968
141neuromuscular process controlling balance (GO:0050885)2.72095331
142Sertoli cell development (GO:0060009)2.71808752
143negative regulation of meiosis (GO:0045835)2.71550261
144neurotransmitter catabolic process (GO:0042135)2.71057673
145negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.69801383
146positive regulation of mRNA metabolic process (GO:1903313)2.69349929
147cilium organization (GO:0044782)2.68870284
148regulation of mRNA splicing, via spliceosome (GO:0048024)2.68400308
149amino acid import (GO:0043090)2.67246973
150tongue development (GO:0043586)2.66516874
151positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.65312901
152regulation of respiratory system process (GO:0044065)2.65263005
153synaptic vesicle docking involved in exocytosis (GO:0016081)2.65025352
154negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.64844449
155protein K6-linked ubiquitination (GO:0085020)2.64794704
156auditory behavior (GO:0031223)2.64521070
157regulation of voltage-gated calcium channel activity (GO:1901385)2.64355290
158negative regulation of alpha-beta T cell differentiation (GO:0046639)2.64352390
159membrane hyperpolarization (GO:0060081)2.64083252
160potassium ion import (GO:0010107)2.63904742
161regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.63847717
162regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.63847717
163axonal fasciculation (GO:0007413)2.62366137
164behavioral response to ethanol (GO:0048149)2.62141330
165eye photoreceptor cell differentiation (GO:0001754)2.62139494
166photoreceptor cell differentiation (GO:0046530)2.62139494
167regulation of neurotransmitter secretion (GO:0046928)2.62050853
168membrane depolarization (GO:0051899)2.61718394
169regulation of synaptic transmission, glutamatergic (GO:0051966)2.61312439
170synaptic vesicle endocytosis (GO:0048488)2.60775905
171C-terminal protein amino acid modification (GO:0018410)2.60658935
172cerebral cortex radially oriented cell migration (GO:0021799)2.60436080
173neuron fate determination (GO:0048664)2.60354122
174head development (GO:0060322)2.60157726
175regulation of neurotransmitter uptake (GO:0051580)2.59630585
176regulation of synaptic plasticity (GO:0048167)2.59416869
177negative regulation of protein localization to cell surface (GO:2000009)2.59321930
178male sex determination (GO:0030238)2.59185973
179peptidyl-tyrosine autophosphorylation (GO:0038083)2.58731926
180ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.58200524
181glycerophospholipid catabolic process (GO:0046475)2.57794493
182nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.57507647
183regulation of dendritic spine development (GO:0060998)2.57488820
184postsynaptic membrane organization (GO:0001941)2.57114115
185regulation of glutamate secretion (GO:0014048)2.56755704
186snRNA transcription (GO:0009301)2.56165946
187regulation of synaptic transmission, GABAergic (GO:0032228)2.55938044
188central nervous system neuron axonogenesis (GO:0021955)2.55914547
189exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.54170843
190behavioral response to cocaine (GO:0048148)2.53672452
191neurotransmitter uptake (GO:0001504)2.53434263
192cell migration in hindbrain (GO:0021535)2.53063857
193synapse assembly (GO:0007416)2.52696242
194positive regulation of male gonad development (GO:2000020)2.52417321
195regulation of amyloid precursor protein catabolic process (GO:1902991)2.51073442
196histone H2A acetylation (GO:0043968)2.49939709

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.18314815
2GBX2_23144817_ChIP-Seq_PC3_Human3.38843329
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.22007215
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.12094919
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.85040776
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78067016
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.77673928
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64414430
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.63311972
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49375130
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.41955632
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37422665
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37422665
14TAF15_26573619_Chip-Seq_HEK293_Human2.33460597
15EWS_26573619_Chip-Seq_HEK293_Human2.30980846
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29776636
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28475702
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26256230
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.26058039
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22889903
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20718518
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20639919
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.19124705
24REST_21632747_ChIP-Seq_MESCs_Mouse2.14674730
25AR_21572438_ChIP-Seq_LNCaP_Human2.09165416
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.08392015
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04331924
28ELK1_19687146_ChIP-ChIP_HELA_Human2.01883659
29DROSHA_22980978_ChIP-Seq_HELA_Human2.00995779
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.95764033
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.93935568
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93899307
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.87502381
34CBP_20019798_ChIP-Seq_JUKART_Human1.84739212
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.84739212
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78349981
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75860761
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73396752
39IRF1_19129219_ChIP-ChIP_H3396_Human1.72550946
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70365401
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70219162
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.68545010
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.67509588
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.67497747
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65730127
46MYC_18940864_ChIP-ChIP_HL60_Human1.62243985
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61078345
48SMAD4_21799915_ChIP-Seq_A2780_Human1.60678562
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60073065
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.55249975
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54936160
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54751375
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53669245
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53451980
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52532914
56VDR_23849224_ChIP-Seq_CD4+_Human1.52104946
57P300_19829295_ChIP-Seq_ESCs_Human1.47758455
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45814569
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45212810
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44981281
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43976944
62BCAT_22108803_ChIP-Seq_LS180_Human1.42847992
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.41970789
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38419935
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37937586
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37471840
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37192491
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.37070960
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.35108736
70TP53_22573176_ChIP-Seq_HFKS_Human1.32072106
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31406953
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.31050968
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31003450
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30726966
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30726966
76STAT3_23295773_ChIP-Seq_U87_Human1.30715194
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29528405
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28688875
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27695868
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27489625
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26485536
82ETS1_20019798_ChIP-Seq_JURKAT_Human1.26450318
83ER_23166858_ChIP-Seq_MCF-7_Human1.26413973
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26222503
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.25545811
86CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24448124
87SOX2_19829295_ChIP-Seq_ESCs_Human1.24102639
88NANOG_19829295_ChIP-Seq_ESCs_Human1.24102639
89VDR_22108803_ChIP-Seq_LS180_Human1.23876485
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23701381
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.20041327
92ERG_21242973_ChIP-ChIP_JURKAT_Human1.19865441
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19806531
94* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19137675
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.19114410
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18951981
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.18911538
98AHR_22903824_ChIP-Seq_MCF-7_Human1.18168694
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17817243
100ZNF274_21170338_ChIP-Seq_K562_Hela1.16664580
101TCF4_22108803_ChIP-Seq_LS180_Human1.16595225
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.15923442
103JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15366331
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14970340
105AR_25329375_ChIP-Seq_VCAP_Human1.14443032
106TCF4_23295773_ChIP-Seq_U87_Human1.14362802
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13143154
108WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13130065
109P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13126197
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11227646
111KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10751749
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10032581
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08411699
114CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07545313
115FUS_26573619_Chip-Seq_HEK293_Human1.07518588
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06969144
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06264651
118PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06035783
119VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05977658
120RING1B_27294783_Chip-Seq_ESCs_Mouse1.05790304
121SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05076294
122RUNX2_22187159_ChIP-Seq_PCA_Human1.04896899
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04056305
124RNF2_27304074_Chip-Seq_NSC_Mouse1.04032314
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03751230
126TP53_16413492_ChIP-PET_HCT116_Human1.03422655
127ELK1_22589737_ChIP-Seq_MCF10A_Human1.02883561
128KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02497513
129FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02333197
130* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01548416
131SOX9_26525672_Chip-Seq_HEART_Mouse1.01099603
132AR_19668381_ChIP-Seq_PC3_Human1.00467873
133PRDM14_20953172_ChIP-Seq_ESCs_Human1.00455195
134* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00444529
135* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00444529
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99394029
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99222339
138RING1B_27294783_Chip-Seq_NPCs_Mouse0.98493945
139NANOG_18555785_Chip-Seq_ESCs_Mouse0.97895766
140CDX2_22108803_ChIP-Seq_LS180_Human0.97619131
141JUN_21703547_ChIP-Seq_K562_Human0.97562285
142FOXP3_21729870_ChIP-Seq_TREG_Human0.97440566
143STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97296393
144NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97022998
145SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96827766
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96454451
147LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95690218
148SMAD4_21741376_ChIP-Seq_HESCs_Human0.93031371
149IGF1R_20145208_ChIP-Seq_DFB_Human0.92964601
150PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92028826
151MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90240175
152YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89409461
153EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89105645
154SMAD4_21741376_ChIP-Seq_EPCs_Human0.88439668
155TP53_18474530_ChIP-ChIP_U2OS_Human0.88349413
156* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88022833
157CMYC_18555785_Chip-Seq_ESCs_Mouse0.87236949
158EP300_21415370_ChIP-Seq_HL-1_Mouse0.86760206
159E2F1_18555785_Chip-Seq_ESCs_Mouse0.86720250

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.91158162
2MP0003880_abnormal_central_pattern4.82397055
3MP0004270_analgesia3.73596214
4MP0003635_abnormal_synaptic_transmissio3.50488029
5MP0006292_abnormal_olfactory_placode3.41526059
6MP0002064_seizures3.12150221
7MP0002234_abnormal_pharynx_morphology3.07774104
8MP0003890_abnormal_embryonic-extraembry3.00335898
9MP0009745_abnormal_behavioral_response3.00279577
10MP0008877_abnormal_DNA_methylation2.93341744
11MP0009046_muscle_twitch2.89213282
12MP0001486_abnormal_startle_reflex2.88892419
13MP0002272_abnormal_nervous_system2.87518008
14MP0002063_abnormal_learning/memory/cond2.65022211
15MP0005423_abnormal_somatic_nervous2.64788693
16MP0000920_abnormal_myelination2.62554950
17MP0001968_abnormal_touch/_nociception2.56259064
18MP0008789_abnormal_olfactory_epithelium2.53290144
19MP0003283_abnormal_digestive_organ2.52737969
20MP0002102_abnormal_ear_morphology2.52561224
21MP0002734_abnormal_mechanical_nocicepti2.51525477
22MP0002572_abnormal_emotion/affect_behav2.43621609
23MP0002822_catalepsy2.38698331
24MP0008995_early_reproductive_senescence2.34612060
25MP0003011_delayed_dark_adaptation2.33018085
26MP0004133_heterotaxia2.18479922
27MP0000372_irregular_coat_pigmentation2.17839102
28MP0001440_abnormal_grooming_behavior2.14766797
29MP0003329_amyloid_beta_deposits2.10775869
30MP0001293_anophthalmia2.10434671
31MP0010030_abnormal_orbit_morphology2.04889957
32MP0002736_abnormal_nociception_after2.03861961
33MP0001501_abnormal_sleep_pattern2.00834491
34MP0003690_abnormal_glial_cell1.99495614
35MP0005499_abnormal_olfactory_system1.99037295
36MP0005394_taste/olfaction_phenotype1.99037295
37MP0002735_abnormal_chemical_nociception1.98341409
38MP0002733_abnormal_thermal_nociception1.96702202
39MP0001970_abnormal_pain_threshold1.96301488
40MP0002067_abnormal_sensory_capabilities1.94679247
41MP0003121_genomic_imprinting1.88317839
42MP0002751_abnormal_autonomic_nervous1.85790694
43MP0003693_abnormal_embryo_hatching1.83286338
44MP0001529_abnormal_vocalization1.80701536
45MP0008569_lethality_at_weaning1.80017466
46MP0000778_abnormal_nervous_system1.79195254
47MP0004885_abnormal_endolymph1.78899375
48MP0004742_abnormal_vestibular_system1.77652957
49MP0004142_abnormal_muscle_tone1.76600735
50MP0001905_abnormal_dopamine_level1.72316579
51MP0000427_abnormal_hair_cycle1.68883950
52MP0006276_abnormal_autonomic_nervous1.68293757
53MP0004924_abnormal_behavior1.66890429
54MP0005386_behavior/neurological_phenoty1.66890429
55MP0005551_abnormal_eye_electrophysiolog1.57034125
56MP0002229_neurodegeneration1.53956193
57MP0000955_abnormal_spinal_cord1.53252100
58MP0003633_abnormal_nervous_system1.48266459
59MP0001324_abnormal_eye_pigmentation1.47048494
60MP0002066_abnormal_motor_capabilities/c1.46994444
61MP0002882_abnormal_neuron_morphology1.46349705
62MP0002557_abnormal_social/conspecific_i1.45449797
63MP0003634_abnormal_glial_cell1.44130962
64MP0008058_abnormal_DNA_repair1.41924262
65MP0000383_abnormal_hair_follicle1.41351727
66MP0009780_abnormal_chondrocyte_physiolo1.41019323
67MP0002184_abnormal_innervation1.37902916
68MP0002653_abnormal_ependyma_morphology1.37334891
69MP0003631_nervous_system_phenotype1.35563140
70MP0001502_abnormal_circadian_rhythm1.32959585
71MP0000569_abnormal_digit_pigmentation1.32205570
72MP0002233_abnormal_nose_morphology1.32162921
73MP0000613_abnormal_salivary_gland1.30825049
74MP0005646_abnormal_pituitary_gland1.30072866
75MP0004811_abnormal_neuron_physiology1.29214042
76MP0003195_calcinosis1.28783076
77MP0003632_abnormal_nervous_system1.25427705
78MP0000647_abnormal_sebaceous_gland1.23686749
79MP0005409_darkened_coat_color1.22550507
80MP0003938_abnormal_ear_development1.20639839
81MP0004145_abnormal_muscle_electrophysio1.20435005
82MP0005171_absent_coat_pigmentation1.14647073
83MP0002938_white_spotting1.13520560
84MP0001984_abnormal_olfaction1.12923123
85MP0003755_abnormal_palate_morphology1.12184858
86MP0005645_abnormal_hypothalamus_physiol1.11838232
87MP0002282_abnormal_trachea_morphology1.10226983
88MP0005391_vision/eye_phenotype1.09651919
89MP0002210_abnormal_sex_determination1.09122630
90MP0000604_amyloidosis1.08729871
91MP0004043_abnormal_pH_regulation1.07948497
92MP0001919_abnormal_reproductive_system1.07146689
93MP0006072_abnormal_retinal_apoptosis1.06719034
94MP0001286_abnormal_eye_development1.06547795
95MP0002909_abnormal_adrenal_gland1.05162894
96MP0000751_myopathy1.04455710
97MP0002837_dystrophic_cardiac_calcinosis1.03446020
98MP0001485_abnormal_pinna_reflex1.00624066
99MP0002152_abnormal_brain_morphology0.98678223
100MP0002638_abnormal_pupillary_reflex0.98620141
101MP0002752_abnormal_somatic_nervous0.97757655
102MP0003787_abnormal_imprinting0.96639276
103MP0003786_premature_aging0.96585585
104MP0001963_abnormal_hearing_physiology0.95574135
105MP0008874_decreased_physiological_sensi0.95413585
106MP0002332_abnormal_exercise_endurance0.91790986
107MP0010678_abnormal_skin_adnexa0.90438226
108MP0004085_abnormal_heartbeat0.89464541
109MP0003137_abnormal_impulse_conducting0.88477636
110MP0005535_abnormal_body_temperature0.88222980
111MP0001929_abnormal_gametogenesis0.88182228
112MP0004858_abnormal_nervous_system0.88150329
113MP0000653_abnormal_sex_gland0.87883452
114MP0001188_hyperpigmentation0.87839631
115MP0003861_abnormal_nervous_system0.87786366
116MP0003950_abnormal_plasma_membrane0.87486607
117MP0005253_abnormal_eye_physiology0.86708510
118MP0003122_maternal_imprinting0.86330056
119MP0003698_abnormal_male_reproductive0.86141279
120MP0005266_abnormal_metabolism0.83722728
121MP0005377_hearing/vestibular/ear_phenot0.82659697
122MP0003878_abnormal_ear_physiology0.82659697
123MP0003252_abnormal_bile_duct0.82259926
124MP0006035_abnormal_mitochondrial_morpho0.82196464
125MP0001145_abnormal_male_reproductive0.82088991
126MP0002069_abnormal_eating/drinking_beha0.80860267
127MP0004036_abnormal_muscle_relaxation0.80185582
128MP0001299_abnormal_eye_distance/0.80145144
129MP0001177_atelectasis0.79752612
130MP0005623_abnormal_meninges_morphology0.79320239
131MP0008872_abnormal_physiological_respon0.78992579
132MP0000747_muscle_weakness0.77894748
133MP0002090_abnormal_vision0.76996990
134MP0003646_muscle_fatigue0.76965355
135MP0003879_abnormal_hair_cell0.75238472
136MP0003936_abnormal_reproductive_system0.73581893
137MP0004215_abnormal_myocardial_fiber0.73479237
138MP0005174_abnormal_tail_pigmentation0.72801029
139MP0002697_abnormal_eye_size0.72334864
140MP0005310_abnormal_salivary_gland0.70567315
141MP0009697_abnormal_copulation0.70419891
142MP0003656_abnormal_erythrocyte_physiolo0.70409063
143MP0004147_increased_porphyrin_level0.69195631
144MP0004484_altered_response_of0.68693120
145MP0000049_abnormal_middle_ear0.67946688
146MP0000013_abnormal_adipose_tissue0.67630492
147MP0003186_abnormal_redox_activity0.66651292
148MP0005195_abnormal_posterior_eye0.65472748
149MP0003136_yellow_coat_color0.61662539
150MP0010386_abnormal_urinary_bladder0.59169089
151MP0003075_altered_response_to0.56985446
152MP0001943_abnormal_respiration0.56453110
153MP0000639_abnormal_adrenal_gland0.56116867
154MP0000631_abnormal_neuroendocrine_gland0.56061106
155MP0000026_abnormal_inner_ear0.53046842
156MP0005620_abnormal_muscle_contractility0.52019611
157MP0000230_abnormal_systemic_arterial0.51772175
158MP0002009_preneoplasia0.51718010

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.88783911
2Myokymia (HP:0002411)5.78657425
3Neurofibrillary tangles (HP:0002185)4.72695599
4Focal seizures (HP:0007359)4.56480047
5Degeneration of the lateral corticospinal tracts (HP:0002314)4.31356973
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.31356973
7Atonic seizures (HP:0010819)4.31306965
8Abnormality of the corticospinal tract (HP:0002492)3.96085129
9Pancreatic cysts (HP:0001737)3.95104790
10Pancreatic fibrosis (HP:0100732)3.91496134
11Epileptic encephalopathy (HP:0200134)3.86540409
12Action tremor (HP:0002345)3.85507751
13Tubular atrophy (HP:0000092)3.83348329
14Cerebral inclusion bodies (HP:0100314)3.83250617
15Oligodactyly (hands) (HP:0001180)3.80903028
16Visual hallucinations (HP:0002367)3.77668034
17Supranuclear gaze palsy (HP:0000605)3.76182813
18Dysmetria (HP:0001310)3.71262520
19Peripheral hypomyelination (HP:0007182)3.71250263
20Progressive cerebellar ataxia (HP:0002073)3.66480514
21Abnormality of midbrain morphology (HP:0002418)3.60988265
22Molar tooth sign on MRI (HP:0002419)3.60988265
233-Methylglutaconic aciduria (HP:0003535)3.54871543
24Abnormality of the labia minora (HP:0012880)3.53331693
25Medial flaring of the eyebrow (HP:0010747)3.41889970
26Febrile seizures (HP:0002373)3.40299920
27Dysdiadochokinesis (HP:0002075)3.38711583
28Dialeptic seizures (HP:0011146)3.36388581
29Scanning speech (HP:0002168)3.34400595
30Generalized tonic-clonic seizures (HP:0002069)3.29407585
31Absence seizures (HP:0002121)3.29123259
32Spastic gait (HP:0002064)3.23549903
33True hermaphroditism (HP:0010459)3.22435766
34Intention tremor (HP:0002080)3.22358545
35Insidious onset (HP:0003587)3.20598390
36Termporal pattern (HP:0011008)3.20598390
37Congenital primary aphakia (HP:0007707)3.12562898
38Nephronophthisis (HP:0000090)3.06728868
39Ankle clonus (HP:0011448)3.06556226
40Hyperventilation (HP:0002883)3.06424269
41Sensory axonal neuropathy (HP:0003390)2.97168971
42Gaze-evoked nystagmus (HP:0000640)2.94728744
43Nephrogenic diabetes insipidus (HP:0009806)2.90746225
44Broad-based gait (HP:0002136)2.88562855
45Abnormality of the pons (HP:0007361)2.87920954
46Chronic hepatic failure (HP:0100626)2.86164392
47Cystic liver disease (HP:0006706)2.85310469
48Genital tract atresia (HP:0001827)2.83121604
49Urinary bladder sphincter dysfunction (HP:0002839)2.81531611
50Abnormality of the renal medulla (HP:0100957)2.78753549
51Acute necrotizing encephalopathy (HP:0006965)2.76724890
52Onion bulb formation (HP:0003383)2.76328207
53Anxiety (HP:0000739)2.74121041
54Truncal ataxia (HP:0002078)2.72834766
55Type II lissencephaly (HP:0007260)2.68367651
56Anophthalmia (HP:0000528)2.67169280
57Volvulus (HP:0002580)2.65557097
58Aplasia/Hypoplasia of the tongue (HP:0010295)2.61281040
59Hemiparesis (HP:0001269)2.60970253
60Hypoplasia of the pons (HP:0012110)2.60362124
61Depression (HP:0000716)2.60063936
62Abdominal situs inversus (HP:0003363)2.57935693
63Abnormality of abdominal situs (HP:0011620)2.57935693
64Postural instability (HP:0002172)2.57884365
65Pendular nystagmus (HP:0012043)2.55223260
66Oligodactyly (HP:0012165)2.52441311
67Clumsiness (HP:0002312)2.51700217
68Sclerocornea (HP:0000647)2.50784577
69Diplopia (HP:0000651)2.47409494
70Abnormality of binocular vision (HP:0011514)2.47409494
71Pheochromocytoma (HP:0002666)2.46091140
72Lower limb muscle weakness (HP:0007340)2.44584493
73Chorioretinal atrophy (HP:0000533)2.44262941
74Generalized myoclonic seizures (HP:0002123)2.43907805
75Impaired vibration sensation in the lower limbs (HP:0002166)2.43614041
76Progressive inability to walk (HP:0002505)2.43429925
77Male pseudohermaphroditism (HP:0000037)2.41551341
78Abnormality of the renal cortex (HP:0011035)2.40653473
79Posterior subcapsular cataract (HP:0007787)2.40156068
80Progressive macrocephaly (HP:0004481)2.39929402
81Anencephaly (HP:0002323)2.39564804
82Bile duct proliferation (HP:0001408)2.37727948
83Abnormal biliary tract physiology (HP:0012439)2.37727948
84Acute encephalopathy (HP:0006846)2.37553086
85Urinary urgency (HP:0000012)2.37288683
86Poor eye contact (HP:0000817)2.35231738
87Poor coordination (HP:0002370)2.35056785
88Abnormal mitochondria in muscle tissue (HP:0008316)2.34165792
89Abnormal eating behavior (HP:0100738)2.31191871
90Excessive salivation (HP:0003781)2.29851113
91Drooling (HP:0002307)2.29851113
92Lissencephaly (HP:0001339)2.28530847
93Impaired social interactions (HP:0000735)2.23741010
94Abnormal social behavior (HP:0012433)2.23741010
95Occipital encephalocele (HP:0002085)2.19460985
96Amblyopia (HP:0000646)2.17518414
97Tented upper lip vermilion (HP:0010804)2.16618807
98Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.16464625
99Hypothermia (HP:0002045)2.16423940
100Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15771955
101Megalencephaly (HP:0001355)2.14978886
102Bowel incontinence (HP:0002607)2.13902815
103Neuroendocrine neoplasm (HP:0100634)2.11906262
104Congenital stationary night blindness (HP:0007642)2.09029321
105Cerebral hemorrhage (HP:0001342)2.07966739
106Patellar aplasia (HP:0006443)2.07850081
107Preaxial hand polydactyly (HP:0001177)2.06228144
108Abnormal auditory evoked potentials (HP:0006958)2.06068716
109Mutism (HP:0002300)2.05709607
110Blue irides (HP:0000635)2.05506086
111Thickened helices (HP:0000391)2.05169101
112Increased circulating renin level (HP:0000848)2.03848780
113Abnormal drinking behavior (HP:0030082)2.03461627
114Polydipsia (HP:0001959)2.03461627
115Limb dystonia (HP:0002451)2.01434391
116Dandy-Walker malformation (HP:0001305)2.01064210
117Abnormal large intestine physiology (HP:0012700)1.99841243
118Morphological abnormality of the pyramidal tract (HP:0002062)1.99679047
119Genetic anticipation (HP:0003743)1.99129168
120Clonus (HP:0002169)1.98221996
121Absent speech (HP:0001344)1.97621468
122Type 2 muscle fiber atrophy (HP:0003554)1.96878771
123Postaxial hand polydactyly (HP:0001162)1.96316754
124Polyuria (HP:0000103)1.95299212
125Agitation (HP:0000713)1.94177814
126Slow saccadic eye movements (HP:0000514)1.93776590
127Postaxial foot polydactyly (HP:0001830)1.93590096
128Neuronal loss in central nervous system (HP:0002529)1.93461364
129Retinal dysplasia (HP:0007973)1.92548993
130Epileptiform EEG discharges (HP:0011182)1.91971211
131Psychosis (HP:0000709)1.90976721
132Increased CSF lactate (HP:0002490)1.90868350
133Ependymoma (HP:0002888)1.90715723
134Aplasia/Hypoplasia of the patella (HP:0006498)1.89001712
135Impaired vibratory sensation (HP:0002495)1.88415440
136Decreased motor nerve conduction velocity (HP:0003431)1.87915747
137EEG with generalized epileptiform discharges (HP:0011198)1.87237906
138Decreased testicular size (HP:0008734)1.87205869
139Status epilepticus (HP:0002133)1.85903157
140Bradykinesia (HP:0002067)1.85762173
141Delusions (HP:0000746)1.85547821
142Narrow forehead (HP:0000341)1.85492531
143Shawl scrotum (HP:0000049)1.85110123
144Aplasia/Hypoplasia of the uvula (HP:0010293)1.84580271
145Gait imbalance (HP:0002141)1.84266470
146Labial hypoplasia (HP:0000066)1.84212206
147Cerebellar dysplasia (HP:0007033)1.83736493
148Hammertoe (HP:0001765)1.83025181
149Chorioretinal coloboma (HP:0000567)1.82091133
150Astigmatism (HP:0000483)1.81662041
151Abnormality of saccadic eye movements (HP:0000570)1.81346672
152Septo-optic dysplasia (HP:0100842)1.81266042
153Ectopic kidney (HP:0000086)1.81049719
154Foot dorsiflexor weakness (HP:0009027)1.79468263
155Aplasia involving bones of the extremities (HP:0009825)1.79272818
156Aplasia involving bones of the upper limbs (HP:0009823)1.79272818
157Aplasia of the phalanges of the hand (HP:0009802)1.79272818
158Specific learning disability (HP:0001328)1.77505405
159Akinesia (HP:0002304)1.77243811
160Hypsarrhythmia (HP:0002521)1.77043428
161Conjugated hyperbilirubinemia (HP:0002908)1.76818904
162Gait ataxia (HP:0002066)1.76666550
163Metabolic alkalosis (HP:0200114)1.76275939
164Astrocytoma (HP:0009592)1.76055239
165Abnormality of the astrocytes (HP:0100707)1.76055239
166Abnormal ciliary motility (HP:0012262)1.75810237
167Disproportionate short-trunk short stature (HP:0003521)1.75615077
168Optic nerve hypoplasia (HP:0000609)1.74128009
169Postural tremor (HP:0002174)1.73872934
170Vaginal atresia (HP:0000148)1.73457260
171Choreoathetosis (HP:0001266)1.71245357
172Exotropia (HP:0000577)1.71158131
173Congenital hepatic fibrosis (HP:0002612)1.71046847
174Optic disc pallor (HP:0000543)1.70929772
175Mitochondrial inheritance (HP:0001427)1.70841763
176Microretrognathia (HP:0000308)1.70683360
177Leukodystrophy (HP:0002415)1.70278008
178Hemiplegia (HP:0002301)1.70135775
179Pachygyria (HP:0001302)1.70028545
180Abnormality of the anterior horn cell (HP:0006802)1.69728015
181Degeneration of anterior horn cells (HP:0002398)1.69728015
182Highly arched eyebrow (HP:0002553)1.68144212
183Increased serum lactate (HP:0002151)1.67751388
184Hypomagnesemia (HP:0002917)1.67751150
185Intestinal atresia (HP:0011100)1.67637908
186Supernumerary spleens (HP:0009799)1.66662114
187Abnormal rod and cone electroretinograms (HP:0008323)1.66508481
188Proximal tubulopathy (HP:0000114)1.65571497
189Thin upper lip vermilion (HP:0000219)1.65161596
190Hepatocellular necrosis (HP:0001404)1.64766138

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.11694200
2STK393.00998574
3EPHA42.99164550
4SRPK12.89243876
5MKNK22.82654682
6OXSR12.71611336
7MAP3K42.67130285
8FRK2.66271643
9PNCK2.32086823
10WNK32.30779284
11MAP3K92.28353532
12CASK2.23168312
13MAP2K72.20817111
14ERBB32.08593358
15NTRK12.06964147
16GRK11.93635221
17PAK61.93573427
18MARK11.84660008
19TRIM281.80580222
20GRK51.76414672
21CDK191.75670733
22ACVR1B1.75241261
23AKT31.75172973
24MAP4K21.74798119
25MINK11.73171290
26TNIK1.66098125
27WNK11.65570818
28DAPK21.65283803
29PKN11.64359103
30PIK3CA1.62524687
31MKNK11.62186831
32UHMK11.58966891
33MARK31.58223400
34KSR21.53562560
35NTRK21.52163654
36PRPF4B1.51696003
37MAP2K41.51365686
38NUAK11.50750951
39BCR1.50690586
40SIK31.47417575
41CDK51.43459045
42PHKG11.39045288
43PHKG21.39045288
44WNK41.38165528
45SGK4941.37391926
46SGK2231.37391926
47EIF2AK11.35246600
48ADRBK21.30558301
49CAMK2B1.29188903
50BRSK21.28353501
51BMPR1B1.22170361
52EIF2AK31.19910458
53TGFBR21.19025874
54MAP3K131.18941678
55FES1.18423230
56CAMK2A1.18088461
57PAK31.14816852
58PLK21.14582856
59FGR1.14463588
60MST1R1.13562426
61RIPK41.11729374
62MAPKAPK51.11455570
63MAPK131.10850770
64CAMK2D1.08608434
65PINK11.05482737
66EPHB11.05019010
67DYRK21.02869098
68GRK71.02545695
69MAP3K21.01930732
70PRKD31.01699578
71PRKCH0.96042095
72MARK20.93530317
73CAMK2G0.93261871
74STK380.92545508
75ROCK20.91493783
76CSNK1G20.90814135
77FGFR20.90754695
78TYRO30.90628494
79STK110.90256788
80PTK2B0.89711217
81PLK30.88780800
82NEK60.87993590
83MAPK150.87856829
84CDK140.87317773
85ARAF0.85908578
86PRKCG0.84361462
87CAMK1G0.83563777
88PRKCE0.80697234
89CDK150.79676161
90CDK180.78792668
91VRK10.78066055
92PDPK10.77995159
93BCKDK0.77935538
94EPHA30.77162550
95CSNK1G30.76730070
96DYRK30.76467071
97STK38L0.75399328
98ICK0.74826241
99CSNK1A1L0.74732835
100NME10.73365050
101SGK10.70570456
102DMPK0.70317720
103CDK11A0.68856991
104RET0.64594288
105DYRK1A0.64110035
106PDK10.61793339
107KSR10.60227754
108CSNK1G10.59926193
109ERBB40.58544721
110MAP3K120.58447147
111BMPR20.58434300
112CAMK10.57993706
113MET0.55939266
114HIPK20.55154212
115MUSK0.55054229
116PRKG10.54623739
117PLK10.54622256
118SIK20.54491277
119PRKD10.54305982
120FYN0.53954990
121FER0.53913041
122INSRR0.53689326
123MAPK100.53378248
124TLK10.52840217
125PRKCQ0.52817972
126TRPM70.52555076
127CDC42BPA0.52108398
128CAMKK10.51562319
129LIMK10.51093410
130RPS6KA30.50251666
131BRSK10.50232441
132PRKD20.50220103
133ATM0.49953881
134PRKCI0.49203367
135MST40.48040721
136SGK20.47596476
137ADRBK10.46140118
138IRAK20.45915416
139CSNK1E0.42502125
140IRAK10.41843115
141TAOK30.40745232
142CSNK1A10.39555756
143CDC70.38522197
144TEC0.36584415
145PRKACB0.35524723
146CHUK0.35319619
147CSNK2A10.34889416
148CSNK2A20.34042055
149CHEK10.32785398
150WEE10.32638728
151PRKACA0.32277669
152IRAK40.31950626
153FLT30.30925994
154EIF2AK20.29025415
155TGFBR10.28765533
156RPS6KB10.27652165
157PIK3CG0.24822624
158AURKB0.24637118
159CDK10.23570302

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.55088232
2Protein export_Homo sapiens_hsa030604.42168386
3Nicotine addiction_Homo sapiens_hsa050333.01873422
4GABAergic synapse_Homo sapiens_hsa047272.72639428
5RNA polymerase_Homo sapiens_hsa030202.65438725
6Synaptic vesicle cycle_Homo sapiens_hsa047212.59979873
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40885085
8Basal transcription factors_Homo sapiens_hsa030222.40429448
9Glutamatergic synapse_Homo sapiens_hsa047242.33165806
10Morphine addiction_Homo sapiens_hsa050322.27353988
11Circadian entrainment_Homo sapiens_hsa047132.22190825
12Nitrogen metabolism_Homo sapiens_hsa009102.16263491
13Long-term potentiation_Homo sapiens_hsa047201.93316982
14Amphetamine addiction_Homo sapiens_hsa050311.91034834
15Olfactory transduction_Homo sapiens_hsa047401.88973736
16Salivary secretion_Homo sapiens_hsa049701.83479117
17Dopaminergic synapse_Homo sapiens_hsa047281.83277699
18Fanconi anemia pathway_Homo sapiens_hsa034601.78739251
19Serotonergic synapse_Homo sapiens_hsa047261.73019045
20Insulin secretion_Homo sapiens_hsa049111.67967370
21Long-term depression_Homo sapiens_hsa047301.66971074
22Taste transduction_Homo sapiens_hsa047421.64050613
23Cholinergic synapse_Homo sapiens_hsa047251.63114811
24Collecting duct acid secretion_Homo sapiens_hsa049661.61188110
25Homologous recombination_Homo sapiens_hsa034401.61081579
26Renin secretion_Homo sapiens_hsa049241.57862772
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56413735
28Cocaine addiction_Homo sapiens_hsa050301.55282451
29RNA degradation_Homo sapiens_hsa030181.54766037
30Gastric acid secretion_Homo sapiens_hsa049711.54278267
31Hedgehog signaling pathway_Homo sapiens_hsa043401.51697810
32Proteasome_Homo sapiens_hsa030501.51069118
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48013282
34Propanoate metabolism_Homo sapiens_hsa006401.47632785
35One carbon pool by folate_Homo sapiens_hsa006701.47541063
36Ribosome_Homo sapiens_hsa030101.45078053
37Non-homologous end-joining_Homo sapiens_hsa034501.35582779
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35419667
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35095792
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34994331
41Phototransduction_Homo sapiens_hsa047441.34874981
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34142938
43Tryptophan metabolism_Homo sapiens_hsa003801.32133664
44Oxytocin signaling pathway_Homo sapiens_hsa049211.27869200
45Calcium signaling pathway_Homo sapiens_hsa040201.26970027
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25915333
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24863987
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24543775
49Caffeine metabolism_Homo sapiens_hsa002321.24249778
50Cardiac muscle contraction_Homo sapiens_hsa042601.23276530
51Axon guidance_Homo sapiens_hsa043601.22511363
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21490176
53Fatty acid elongation_Homo sapiens_hsa000621.17408360
54Oxidative phosphorylation_Homo sapiens_hsa001901.16733114
55Basal cell carcinoma_Homo sapiens_hsa052171.14941080
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13081197
57cAMP signaling pathway_Homo sapiens_hsa040241.12527305
58Ether lipid metabolism_Homo sapiens_hsa005651.11657906
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09268979
60Type II diabetes mellitus_Homo sapiens_hsa049301.09226458
61Dorso-ventral axis formation_Homo sapiens_hsa043201.07892244
62GnRH signaling pathway_Homo sapiens_hsa049121.06950029
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06471828
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05688963
65Gap junction_Homo sapiens_hsa045401.03970418
66Vascular smooth muscle contraction_Homo sapiens_hsa042701.02408560
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01658522
68Maturity onset diabetes of the young_Homo sapiens_hsa049501.00995855
69Alzheimers disease_Homo sapiens_hsa050101.00614548
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98384868
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97774208
72Mismatch repair_Homo sapiens_hsa034300.97561455
73ErbB signaling pathway_Homo sapiens_hsa040120.97439464
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94305628
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93563700
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.87212672
77Vibrio cholerae infection_Homo sapiens_hsa051100.86661913
78Linoleic acid metabolism_Homo sapiens_hsa005910.85961583
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85134907
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83457645
81beta-Alanine metabolism_Homo sapiens_hsa004100.82879603
82Estrogen signaling pathway_Homo sapiens_hsa049150.82446409
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82261384
84Butanoate metabolism_Homo sapiens_hsa006500.81937869
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81765157
86Spliceosome_Homo sapiens_hsa030400.81346996
87Renal cell carcinoma_Homo sapiens_hsa052110.81189838
88Steroid biosynthesis_Homo sapiens_hsa001000.80131102
89RNA transport_Homo sapiens_hsa030130.79606283
90Parkinsons disease_Homo sapiens_hsa050120.79246748
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77778241
92Pancreatic secretion_Homo sapiens_hsa049720.77199467
93Vitamin B6 metabolism_Homo sapiens_hsa007500.77147550
94Folate biosynthesis_Homo sapiens_hsa007900.76801621
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76355372
96Hippo signaling pathway_Homo sapiens_hsa043900.74108273
97Choline metabolism in cancer_Homo sapiens_hsa052310.73946420
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73687529
99Pyrimidine metabolism_Homo sapiens_hsa002400.73614498
100Metabolic pathways_Homo sapiens_hsa011000.72952065
101p53 signaling pathway_Homo sapiens_hsa041150.72236910
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70508355
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69246675
104Melanogenesis_Homo sapiens_hsa049160.69214918
105Lysine degradation_Homo sapiens_hsa003100.69042470
106Ras signaling pathway_Homo sapiens_hsa040140.68486020
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.67971801
108Purine metabolism_Homo sapiens_hsa002300.67109194
109MAPK signaling pathway_Homo sapiens_hsa040100.65936332
110Glioma_Homo sapiens_hsa052140.64493071
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63014874
112Sulfur metabolism_Homo sapiens_hsa009200.62883012
113Dilated cardiomyopathy_Homo sapiens_hsa054140.62855107
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62471467
115Bile secretion_Homo sapiens_hsa049760.62082562
116Nucleotide excision repair_Homo sapiens_hsa034200.59648843
117Wnt signaling pathway_Homo sapiens_hsa043100.58950547
118Thyroid hormone synthesis_Homo sapiens_hsa049180.58733003
119Arachidonic acid metabolism_Homo sapiens_hsa005900.57242372
120Arginine and proline metabolism_Homo sapiens_hsa003300.53414619
121Endocytosis_Homo sapiens_hsa041440.53264405
122TGF-beta signaling pathway_Homo sapiens_hsa043500.50162219
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49236321
124Arginine biosynthesis_Homo sapiens_hsa002200.47648972
125Selenocompound metabolism_Homo sapiens_hsa004500.47440518
126Inositol phosphate metabolism_Homo sapiens_hsa005620.47353902
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.47288741
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46620516
129Prion diseases_Homo sapiens_hsa050200.44853100
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44668296
131mRNA surveillance pathway_Homo sapiens_hsa030150.44456382
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43152605
133Rheumatoid arthritis_Homo sapiens_hsa053230.42860590
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42510547
135Ovarian steroidogenesis_Homo sapiens_hsa049130.41783298
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41630311
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40485155
138Oocyte meiosis_Homo sapiens_hsa041140.40215784
139Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39941458
140Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39454698
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39072405
142Sphingolipid metabolism_Homo sapiens_hsa006000.38282215
143Alcoholism_Homo sapiens_hsa050340.38100043
144Rap1 signaling pathway_Homo sapiens_hsa040150.35748806
145Fatty acid metabolism_Homo sapiens_hsa012120.35087544
146Circadian rhythm_Homo sapiens_hsa047100.34174004
147Regulation of autophagy_Homo sapiens_hsa041400.33849121
148Huntingtons disease_Homo sapiens_hsa050160.33716246
149N-Glycan biosynthesis_Homo sapiens_hsa005100.32701755
150Tight junction_Homo sapiens_hsa045300.32392917
151Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31288108
152Steroid hormone biosynthesis_Homo sapiens_hsa001400.29625741
153Glutathione metabolism_Homo sapiens_hsa004800.29109652
154Histidine metabolism_Homo sapiens_hsa003400.28901517

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