ZRSR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.57643247
2regulation of nuclear cell cycle DNA replication (GO:0033262)4.19344452
3ATP synthesis coupled proton transport (GO:0015986)3.73409835
4energy coupled proton transport, down electrochemical gradient (GO:0015985)3.73409835
5kinetochore organization (GO:0051383)3.57823424
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.52800072
7kinetochore assembly (GO:0051382)3.45184412
8behavioral response to nicotine (GO:0035095)3.43008419
9maturation of SSU-rRNA (GO:0030490)3.33842506
10DNA replication checkpoint (GO:0000076)3.28107240
11activated T cell proliferation (GO:0050798)3.28097069
12protein complex biogenesis (GO:0070271)3.27471150
13cytidine metabolic process (GO:0046087)3.22808082
14cytidine catabolic process (GO:0006216)3.22808082
15cytidine deamination (GO:0009972)3.22808082
16regulation of meiosis I (GO:0060631)3.19542908
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.19350641
18cellular response to interleukin-15 (GO:0071350)3.18532151
19chromatin remodeling at centromere (GO:0031055)3.11213845
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.11097179
21negative regulation of cell killing (GO:0031342)3.11097179
22negative regulation of DNA-dependent DNA replication (GO:2000104)3.10241990
23regulation of double-strand break repair via homologous recombination (GO:0010569)3.08291965
24meiotic chromosome segregation (GO:0045132)3.07958959
25RNA-dependent DNA replication (GO:0006278)3.07722047
26histone H4-K12 acetylation (GO:0043983)3.07217215
27telomere maintenance via telomerase (GO:0007004)3.06043884
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.05335170
29response to pheromone (GO:0019236)3.05163703
30microglial cell activation (GO:0001774)3.04229771
31positive regulation of defense response to virus by host (GO:0002230)3.02539340
32mitochondrial respiratory chain complex I assembly (GO:0032981)3.02132567
33NADH dehydrogenase complex assembly (GO:0010257)3.02132567
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.02132567
35adaptation of signaling pathway (GO:0023058)3.01873068
36respiratory chain complex IV assembly (GO:0008535)3.01219306
37CENP-A containing nucleosome assembly (GO:0034080)3.00073092
38pseudouridine synthesis (GO:0001522)2.99271363
39regulation of activation of Janus kinase activity (GO:0010533)2.99168223
40cytochrome complex assembly (GO:0017004)2.97799597
41response to interferon-beta (GO:0035456)2.95576192
42mitochondrial respiratory chain complex assembly (GO:0033108)2.94615062
43regulation of B cell receptor signaling pathway (GO:0050855)2.91896495
44protein localization to kinetochore (GO:0034501)2.91391226
45interferon-gamma production (GO:0032609)2.90114865
46protein K6-linked ubiquitination (GO:0085020)2.89883043
47establishment of protein localization to mitochondrial membrane (GO:0090151)2.88935460
48tolerance induction (GO:0002507)2.88050921
49positive regulation of gamma-delta T cell activation (GO:0046645)2.87064926
50platelet dense granule organization (GO:0060155)2.86058858
51attachment of spindle microtubules to kinetochore (GO:0008608)2.84919773
52protein-cofactor linkage (GO:0018065)2.83963985
53fucose catabolic process (GO:0019317)2.82207168
54L-fucose metabolic process (GO:0042354)2.82207168
55L-fucose catabolic process (GO:0042355)2.82207168
56mitotic sister chromatid segregation (GO:0000070)2.81172032
57cullin deneddylation (GO:0010388)2.78909647
58electron transport chain (GO:0022900)2.77928911
59positive regulation of T-helper 1 type immune response (GO:0002827)2.75404017
60modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.74749991
61positive regulation by organism of defense response of other organism involved in symbiotic interact2.74749991
62modulation by symbiont of host immune response (GO:0052553)2.74749991
63positive regulation by symbiont of host defense response (GO:0052509)2.74749991
64modulation by symbiont of host defense response (GO:0052031)2.74749991
65modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.74749991
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.74648415
67regulation of helicase activity (GO:0051095)2.74242073
68indolalkylamine metabolic process (GO:0006586)2.74182661
69DNA replication-independent nucleosome organization (GO:0034724)2.73663628
70DNA replication-independent nucleosome assembly (GO:0006336)2.73663628
71respiratory electron transport chain (GO:0022904)2.73571462
72pyrimidine ribonucleoside catabolic process (GO:0046133)2.73247780
73regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.70228116
74regulation of mitotic spindle checkpoint (GO:1903504)2.70228116
75mitotic metaphase plate congression (GO:0007080)2.69977123
76negative regulation of T cell mediated immunity (GO:0002710)2.68082108
77negative T cell selection (GO:0043383)2.67113245
78DNA replication initiation (GO:0006270)2.64913292
79piRNA metabolic process (GO:0034587)2.64377030
80daunorubicin metabolic process (GO:0044597)2.60644268
81polyketide metabolic process (GO:0030638)2.60644268
82doxorubicin metabolic process (GO:0044598)2.60644268
83amine catabolic process (GO:0009310)2.60519741
84cellular biogenic amine catabolic process (GO:0042402)2.60519741
85proteasome assembly (GO:0043248)2.59718810
86DNA strand renaturation (GO:0000733)2.59605886
87mast cell activation (GO:0045576)2.58913399
88preassembly of GPI anchor in ER membrane (GO:0016254)2.58519688
89rRNA modification (GO:0000154)2.58207935
90protein deneddylation (GO:0000338)2.57566344
91negative regulation of interleukin-1 production (GO:0032692)2.56785337
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.56005991
93tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.56005991
94tryptophan catabolic process (GO:0006569)2.55630368
95indole-containing compound catabolic process (GO:0042436)2.55630368
96indolalkylamine catabolic process (GO:0046218)2.55630368
97histone arginine methylation (GO:0034969)2.55456443
98negative thymic T cell selection (GO:0045060)2.55011373
99ribonucleoprotein complex biogenesis (GO:0022613)2.54917786
100maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.54888546
101regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.54477033
102regulation of memory T cell differentiation (GO:0043380)2.53739844
103RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.53297601
104spliceosomal snRNP assembly (GO:0000387)2.53123126
105ribosome biogenesis (GO:0042254)2.53017229
106spindle checkpoint (GO:0031577)2.52674630
107maturation of 5.8S rRNA (GO:0000460)2.52294536
108water-soluble vitamin biosynthetic process (GO:0042364)2.51850814
109regulation of double-strand break repair (GO:2000779)2.51414348
110protein neddylation (GO:0045116)2.50858346
111response to interleukin-15 (GO:0070672)2.50630588
112axoneme assembly (GO:0035082)2.49726198
113metaphase plate congression (GO:0051310)2.49643475
114hydrogen ion transmembrane transport (GO:1902600)2.49464650
115negative regulation of interleukin-1 beta production (GO:0032691)2.48883471
116replication fork processing (GO:0031297)2.48818222
117protein localization to chromosome, centromeric region (GO:0071459)2.48479365
118mitotic spindle checkpoint (GO:0071174)2.47788842
119* spliceosomal complex assembly (GO:0000245)2.47531408
120chaperone-mediated protein transport (GO:0072321)2.46179177
121DNA methylation involved in gamete generation (GO:0043046)2.45857118
122microtubule depolymerization (GO:0007019)2.45528535
123nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.45425763
124mast cell degranulation (GO:0043303)2.45259558
125mast cell activation involved in immune response (GO:0002279)2.45259558
126ribosomal small subunit biogenesis (GO:0042274)2.45038452
127ribosomal large subunit biogenesis (GO:0042273)2.45012258
128regulation of interleukin-6 biosynthetic process (GO:0045408)2.44946287
129T-helper 1 type immune response (GO:0042088)2.44871572
130serotonin receptor signaling pathway (GO:0007210)2.44759306
131regulation of telomere maintenance (GO:0032204)2.43455340
132DNA damage response, detection of DNA damage (GO:0042769)2.42381578
133positive regulation of meiosis (GO:0045836)2.41946301
134regulation of T cell mediated cytotoxicity (GO:0001914)2.41445294
135mRNA splice site selection (GO:0006376)2.41335247
136viral mRNA export from host cell nucleus (GO:0046784)2.41216701
137rRNA processing (GO:0006364)2.40202995
138positive regulation of alpha-beta T cell proliferation (GO:0046641)2.40111554
139proton transport (GO:0015992)2.39952235
140tryptophan metabolic process (GO:0006568)2.39727376
141positive regulation of T cell mediated cytotoxicity (GO:0001916)2.39526233
142histone exchange (GO:0043486)2.38503209
143endoderm formation (GO:0001706)2.37814859
144mitotic sister chromatid cohesion (GO:0007064)2.36834780
145regulation of T-helper 1 type immune response (GO:0002825)2.36133305
146histone H2A acetylation (GO:0043968)2.35160312
147spindle assembly checkpoint (GO:0071173)2.34705442
148negative regulation of mast cell activation (GO:0033004)2.34510647
149kidney morphogenesis (GO:0060993)2.33843605
150DNA strand elongation involved in DNA replication (GO:0006271)2.33697909
151neural tube formation (GO:0001841)2.33527527
152hydrogen transport (GO:0006818)2.32961623
153negative regulation of telomere maintenance (GO:0032205)2.32740637
154negative regulation of chromosome segregation (GO:0051985)2.32711217
155rRNA metabolic process (GO:0016072)2.32314384
156regulation of alpha-beta T cell proliferation (GO:0046640)2.32116851
157positive regulation of cellular response to oxidative stress (GO:1900409)2.30737723
158positive regulation of response to oxidative stress (GO:1902884)2.30737723
159epithelial cilium movement (GO:0003351)2.30672605
160mitotic spindle assembly checkpoint (GO:0007094)2.29938824
161mitotic chromosome condensation (GO:0007076)2.29734728
162ATP biosynthetic process (GO:0006754)2.28535455
163regulation of sister chromatid segregation (GO:0033045)2.28192709
164regulation of mitotic sister chromatid separation (GO:0010965)2.28192709
165regulation of mitotic sister chromatid segregation (GO:0033047)2.28192709
166telomere maintenance via telomere lengthening (GO:0010833)2.27931241
167negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.27772421
168negative regulation of sister chromatid segregation (GO:0033046)2.27772421
169negative regulation of mitotic sister chromatid separation (GO:2000816)2.27772421
170negative regulation of mitotic sister chromatid segregation (GO:0033048)2.27772421
171poly(A)+ mRNA export from nucleus (GO:0016973)2.26964629
172positive regulation of mast cell activation (GO:0033005)2.26453894
173regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.25629909
174regulation of mitotic metaphase/anaphase transition (GO:0030071)2.25383768
175DNA strand elongation (GO:0022616)2.25042162
176cellular response to interferon-beta (GO:0035458)2.24960304
177sister chromatid segregation (GO:0000819)2.24784931
178regulation of gamma-delta T cell activation (GO:0046643)2.24760073
179somatic hypermutation of immunoglobulin genes (GO:0016446)2.24748566
180somatic diversification of immune receptors via somatic mutation (GO:0002566)2.24748566
181rRNA methylation (GO:0031167)2.24691505
182regulation of cilium movement (GO:0003352)2.24447929
183telomere maintenance via recombination (GO:0000722)2.23825221
184positive regulation of DNA-dependent DNA replication (GO:2000105)2.23623665
185regulation of gene silencing by RNA (GO:0060966)2.23408723
186regulation of posttranscriptional gene silencing (GO:0060147)2.23408723
187regulation of gene silencing by miRNA (GO:0060964)2.23408723
188negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.23255013
189mitotic recombination (GO:0006312)2.22877367
190histone H3-K4 trimethylation (GO:0080182)2.22623063
191exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.22485133
192intra-S DNA damage checkpoint (GO:0031573)2.22260272
193positive regulation of meiotic cell cycle (GO:0051446)2.22241020

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.80729946
2ZNF274_21170338_ChIP-Seq_K562_Hela3.59924976
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.55520490
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36239870
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.32058009
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.00996055
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.73469483
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.73469483
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.73469483
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.60698870
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.60074693
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58499169
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.55717293
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.52423309
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.48098190
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37792984
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.36922288
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34633467
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.26617018
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15356963
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.14189908
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.11631240
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.10608561
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04054263
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03536295
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01190437
27ELK1_19687146_ChIP-ChIP_HELA_Human1.90096970
28TTF2_22483619_ChIP-Seq_HELA_Human1.87711557
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85162987
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83777769
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.83440825
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82175227
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.81133205
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79066529
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77942647
36EWS_26573619_Chip-Seq_HEK293_Human1.77808388
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75973576
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73653418
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73526678
40TP53_22573176_ChIP-Seq_HFKS_Human1.73349129
41VDR_23849224_ChIP-Seq_CD4+_Human1.72710215
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72548976
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69473144
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.68914232
45FUS_26573619_Chip-Seq_HEK293_Human1.66929617
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.66728126
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66215232
48RNF2_27304074_Chip-Seq_NSC_Mouse1.64733641
49ER_23166858_ChIP-Seq_MCF-7_Human1.63492937
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59791431
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.59348482
52IGF1R_20145208_ChIP-Seq_DFB_Human1.57813340
53GATA3_26560356_Chip-Seq_TH2_Human1.56996627
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.56657698
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55890596
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53429310
57FOXP3_21729870_ChIP-Seq_TREG_Human1.50839050
58* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50755286
59EZH2_22144423_ChIP-Seq_EOC_Human1.46198339
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.45461139
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44891771
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.44682144
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43382636
64RUNX_20019798_ChIP-Seq_JUKART_Human1.43308408
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.42886952
66DCP1A_22483619_ChIP-Seq_HELA_Human1.42155614
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41056142
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40432993
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.40072382
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40072382
71XRN2_22483619_ChIP-Seq_HELA_Human1.39015036
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38235920
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36488183
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35283095
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35007718
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34904419
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29557275
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29086863
79BCAT_22108803_ChIP-Seq_LS180_Human1.28805195
80MYC_18940864_ChIP-ChIP_HL60_Human1.26850096
81AR_20517297_ChIP-Seq_VCAP_Human1.26276173
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26158041
83* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26141714
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26136581
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24630882
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24031128
87ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23841214
88ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23366919
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22746189
90NANOG_19829295_ChIP-Seq_ESCs_Human1.22542827
91SOX2_19829295_ChIP-Seq_ESCs_Human1.22542827
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.21885621
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19861420
94SOX2_16153702_ChIP-ChIP_HESCs_Human1.18620273
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.17707515
96HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16318550
97VDR_22108803_ChIP-Seq_LS180_Human1.15847866
98MYB_26560356_Chip-Seq_TH2_Human1.13912648
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13588971
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13410954
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12846806
102NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11965370
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11894443
104SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11053676
105GATA3_27048872_Chip-Seq_THYMUS_Human1.08840355
106EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08448233
107GBX2_23144817_ChIP-Seq_PC3_Human1.08233226
108EZH2_27294783_Chip-Seq_NPCs_Mouse1.07980995
109TAF15_26573619_Chip-Seq_HEK293_Human1.07968815
110NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.07292366
111NANOG_20526341_ChIP-Seq_ESCs_Human1.07066435
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07039339
113PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06902197
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06324396
115TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06253021
116BP1_19119308_ChIP-ChIP_Hs578T_Human1.05575960
117* GABP_19822575_ChIP-Seq_HepG2_Human1.05370619
118ERA_21632823_ChIP-Seq_H3396_Human1.04829234
119NCOR_22424771_ChIP-Seq_293T_Human1.04394288
120TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03572331
121RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02161154
122* HOXB7_26014856_ChIP-Seq_BT474_Human1.02015920
123RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00348936
124SPI1_23547873_ChIP-Seq_NB4_Human1.00224228
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99754029
126SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98796067
127ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97126614
128SMRT_27268052_Chip-Seq_Bcells_Human0.96985290
129FOXH1_21741376_ChIP-Seq_EPCs_Human0.96965470
130SRF_21415370_ChIP-Seq_HL-1_Mouse0.96933998
131FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96795458
132REST_21632747_ChIP-Seq_MESCs_Mouse0.96524469
133ELK1_22589737_ChIP-Seq_MCF10A_Human0.96443557
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95789068
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95789068
136SMAD_19615063_ChIP-ChIP_OVARY_Human0.95613037
137PRDM14_20953172_ChIP-Seq_ESCs_Human0.95478795
138TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95291185
139TCF4_22108803_ChIP-Seq_LS180_Human0.94694973
140CRX_20693478_ChIP-Seq_RETINA_Mouse0.93850348
141STAT1_20625510_ChIP-Seq_HELA_Human0.93716547
142FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93369978
143IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93097861
144GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93070882
145GATA3_26560356_Chip-Seq_TH1_Human0.92479484
146CBP_20019798_ChIP-Seq_JUKART_Human0.92095729
147IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92095729
148MYC_19829295_ChIP-Seq_ESCs_Human0.91622992
149NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91112316
150RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91099356
151RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91092972
152CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90743149
153IRF1_19129219_ChIP-ChIP_H3396_Human0.90233091
154FLI1_21867929_ChIP-Seq_TH2_Mouse0.90144932
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89306960
156SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87904725
157AR_21909140_ChIP-Seq_LNCAP_Human0.87033837
158SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85974100
159POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85791868
160TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85775526
161CIITA_25753668_ChIP-Seq_RAJI_Human0.83436260
162NANOG_16153702_ChIP-ChIP_HESCs_Human0.83022281
163NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.80940317
164TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80799059
165CBX2_27304074_Chip-Seq_ESCs_Mouse0.79515571
166KDM5A_27292631_Chip-Seq_BREAST_Human0.79081186
167* P300_19829295_ChIP-Seq_ESCs_Human0.78746579
168CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.78549004
169ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.78528641
170CTBP1_25329375_ChIP-Seq_LNCAP_Human0.77640181
171NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.77289679
172SOX2_18555785_ChIP-Seq_MESCs_Mouse0.76742157

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.95776449
2MP0008877_abnormal_DNA_methylation3.43499096
3MP0006292_abnormal_olfactory_placode3.32644405
4MP0003787_abnormal_imprinting3.26951617
5MP0005671_abnormal_response_to3.18376104
6MP0001188_hyperpigmentation3.13970051
7MP0010094_abnormal_chromosome_stability2.73587081
8MP0008058_abnormal_DNA_repair2.59298901
9MP0003121_genomic_imprinting2.55935491
10MP0003123_paternal_imprinting2.47325558
11MP0003111_abnormal_nucleus_morphology2.27889382
12MP0001800_abnormal_humoral_immune2.24833686
13MP0004957_abnormal_blastocyst_morpholog2.23197944
14MP0001835_abnormal_antigen_presentation2.22833486
15MP0001790_abnormal_immune_system2.15460561
16MP0005387_immune_system_phenotype2.15460561
17MP0003693_abnormal_embryo_hatching2.14243959
18MP0000685_abnormal_immune_system2.13882791
19MP0003724_increased_susceptibility_to2.13331394
20MP0003122_maternal_imprinting2.12608214
21MP0009785_altered_susceptibility_to2.04140355
22MP0003077_abnormal_cell_cycle2.03000253
23MP0002148_abnormal_hypersensitivity_rea1.95646189
24MP0003786_premature_aging1.90873036
25MP0008007_abnormal_cellular_replicative1.88316233
26MP0005084_abnormal_gallbladder_morpholo1.86035771
27MP0001986_abnormal_taste_sensitivity1.85760356
28MP0002723_abnormal_immune_serum1.84833098
29MP0008932_abnormal_embryonic_tissue1.81532489
30MP0003890_abnormal_embryonic-extraembry1.81035958
31MP0008872_abnormal_physiological_respon1.75603015
32MP0005000_abnormal_immune_tolerance1.73835385
33MP0003941_abnormal_skin_development1.73657163
34MP0002452_abnormal_antigen_presenting1.72045362
35MP0002009_preneoplasia1.70866612
36MP0003195_calcinosis1.70656407
37MP0002420_abnormal_adaptive_immunity1.68719710
38MP0002876_abnormal_thyroid_physiology1.68188686
39MP0003646_muscle_fatigue1.68120648
40MP0001819_abnormal_immune_cell1.66711177
41MP0002653_abnormal_ependyma_morphology1.65841472
42MP0002102_abnormal_ear_morphology1.63803773
43MP0003136_yellow_coat_color1.61918668
44MP0000569_abnormal_digit_pigmentation1.54734930
45MP0006072_abnormal_retinal_apoptosis1.52864762
46MP0002163_abnormal_gland_morphology1.52777135
47MP0002254_reproductive_system_inflammat1.49014393
48MP0002277_abnormal_respiratory_mucosa1.48226754
49MP0005025_abnormal_response_to1.47737376
50MP0002928_abnormal_bile_duct1.47317110
51MP0001873_stomach_inflammation1.46652449
52MP0000015_abnormal_ear_pigmentation1.46195045
53MP0006082_CNS_inflammation1.46009944
54MP0000372_irregular_coat_pigmentation1.44647981
55MP0002837_dystrophic_cardiac_calcinosis1.41577560
56MP0003011_delayed_dark_adaptation1.41560759
57MP0001485_abnormal_pinna_reflex1.39933454
58MP0005551_abnormal_eye_electrophysiolog1.37745849
59MP0001919_abnormal_reproductive_system1.36701295
60MP0003436_decreased_susceptibility_to1.36418018
61MP0002138_abnormal_hepatobiliary_system1.35252966
62MP0003878_abnormal_ear_physiology1.34408094
63MP0005377_hearing/vestibular/ear_phenot1.34408094
64MP0002419_abnormal_innate_immunity1.33676073
65MP0003315_abnormal_perineum_morphology1.32266461
66MP0001984_abnormal_olfaction1.29681620
67MP0000516_abnormal_urinary_system1.29353799
68MP0005367_renal/urinary_system_phenotyp1.29353799
69MP0000716_abnormal_immune_system1.27312116
70MP0006276_abnormal_autonomic_nervous1.27083436
71MP0008995_early_reproductive_senescence1.26670723
72MP0003763_abnormal_thymus_physiology1.25926726
73MP0002735_abnormal_chemical_nociception1.24056615
74MP0002210_abnormal_sex_determination1.23400491
75MP0004885_abnormal_endolymph1.22455663
76MP0008875_abnormal_xenobiotic_pharmacok1.21374467
77MP0005310_abnormal_salivary_gland1.21087426
78MP0003880_abnormal_central_pattern1.20826682
79MP0004742_abnormal_vestibular_system1.19758203
80MP0000049_abnormal_middle_ear1.19097230
81MP0005645_abnormal_hypothalamus_physiol1.18902385
82MP0002398_abnormal_bone_marrow1.18035438
83MP0003755_abnormal_palate_morphology1.16923828
84MP0000689_abnormal_spleen_morphology1.16595582
85MP0002938_white_spotting1.15613980
86MP0004133_heterotaxia1.15506834
87MP0002405_respiratory_system_inflammati1.15287588
88MP0005253_abnormal_eye_physiology1.14088364
89MP0000350_abnormal_cell_proliferation1.11550637
90MP0004043_abnormal_pH_regulation1.11121024
91MP0002396_abnormal_hematopoietic_system1.09991912
92MP0001486_abnormal_startle_reflex1.09082341
93MP0005174_abnormal_tail_pigmentation1.08967425
94MP0009764_decreased_sensitivity_to1.07994508
95MP0005646_abnormal_pituitary_gland1.07665918
96MP0010030_abnormal_orbit_morphology1.07124549
97MP0002272_abnormal_nervous_system1.05580165
98MP0004381_abnormal_hair_follicle1.04757777
99MP0002693_abnormal_pancreas_physiology1.04643410
100MP0001845_abnormal_inflammatory_respons1.04542463
101MP0005389_reproductive_system_phenotype1.00210184
102MP0002572_abnormal_emotion/affect_behav1.00149047
103MP0004145_abnormal_muscle_electrophysio1.00124765
104MP0001145_abnormal_male_reproductive0.99912889
105MP0009379_abnormal_foot_pigmentation0.99499509
106MP0002095_abnormal_skin_pigmentation0.97236181
107MP0000537_abnormal_urethra_morphology0.95987855
108MP0005379_endocrine/exocrine_gland_phen0.95570298
109MP0005394_taste/olfaction_phenotype0.94942799
110MP0005499_abnormal_olfactory_system0.94942799
111MP0003635_abnormal_synaptic_transmissio0.93829469
112MP0009745_abnormal_behavioral_response0.93596540
113MP0002249_abnormal_larynx_morphology0.93349841
114MP0005075_abnormal_melanosome_morpholog0.92426669
115MP0004808_abnormal_hematopoietic_stem0.92418392
116MP0004859_abnormal_synaptic_plasticity0.92231724
117MP0000678_abnormal_parathyroid_gland0.91726995
118MP0001968_abnormal_touch/_nociception0.91511956
119MP0000703_abnormal_thymus_morphology0.91494135
120MP0004142_abnormal_muscle_tone0.91336261
121MP0001293_anophthalmia0.91313223
122MP0003937_abnormal_limbs/digits/tail_de0.88980388
123MP0002722_abnormal_immune_system0.88878918
124MP0002429_abnormal_blood_cell0.88812333
125MP0003385_abnormal_body_wall0.88676119
126MP0003938_abnormal_ear_development0.88428580
127MP0003119_abnormal_digestive_system0.88139634
128MP0002638_abnormal_pupillary_reflex0.87731672
129MP0000653_abnormal_sex_gland0.87566178
130MP0002085_abnormal_embryonic_tissue0.87029710
131MP0003567_abnormal_fetal_cardiomyocyte0.86490843
132MP0002063_abnormal_learning/memory/cond0.84257103
133MP0002733_abnormal_thermal_nociception0.83375565
134MP0009333_abnormal_splenocyte_physiolog0.82948364
135MP0003183_abnormal_peptide_metabolism0.82728458
136MP0008961_abnormal_basal_metabolism0.82642135
137MP0002084_abnormal_developmental_patter0.82352468
138MP0001672_abnormal_embryogenesis/_devel0.81718849
139MP0005380_embryogenesis_phenotype0.81718849
140MP0001663_abnormal_digestive_system0.81642050
141MP0002751_abnormal_autonomic_nervous0.81526893
142MP0000566_synostosis0.81300401
143MP0002877_abnormal_melanocyte_morpholog0.80862240
144MP0002177_abnormal_outer_ear0.80099449
145MP0001905_abnormal_dopamine_level0.80097003
146MP0001286_abnormal_eye_development0.80010072
147MP0009250_abnormal_appendicular_skeleto0.79823363
148MP0001501_abnormal_sleep_pattern0.79725875
149MP0002116_abnormal_craniofacial_bone0.79665588
150MP0001440_abnormal_grooming_behavior0.79515502
151MP0008469_abnormal_protein_level0.79477681
152MP0001970_abnormal_pain_threshold0.79453380
153MP0008789_abnormal_olfactory_epithelium0.78984384
154MP0001697_abnormal_embryo_size0.78926210
155MP0009697_abnormal_copulation0.78535670
156MP0000778_abnormal_nervous_system0.78313199
157MP0009046_muscle_twitch0.77619930
158MP0001502_abnormal_circadian_rhythm0.77545341
159MP0002233_abnormal_nose_morphology0.76683389
160MP0001929_abnormal_gametogenesis0.76379373
161MP0002184_abnormal_innervation0.75854471
162MP0002064_seizures0.75841861
163MP0005171_absent_coat_pigmentation0.75657481
164MP0003861_abnormal_nervous_system0.75240610
165MP0002114_abnormal_axial_skeleton0.74130107
166MP0001529_abnormal_vocalization0.73903452
167MP0000432_abnormal_head_morphology0.73348991
168MP0001765_abnormal_ion_homeostasis0.72902151
169MP0003866_abnormal_defecation0.72505276
170MP0004197_abnormal_fetal_growth/weight/0.70659337
171MP0010352_gastrointestinal_tract_polyps0.70243339
172MP0001119_abnormal_female_reproductive0.69949815
173MP0002557_abnormal_social/conspecific_i0.68887339
174MP0002736_abnormal_nociception_after0.67998700
175MP0004924_abnormal_behavior0.67305790
176MP0005386_behavior/neurological_phenoty0.67305790
177MP0000631_abnormal_neuroendocrine_gland0.66931083

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.22552417
2Chromsome breakage (HP:0040012)3.83885074
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.77153132
4Pancreatic cysts (HP:0001737)3.74932245
5Molar tooth sign on MRI (HP:0002419)3.61396199
6Abnormality of midbrain morphology (HP:0002418)3.61396199
7Supernumerary spleens (HP:0009799)3.23284806
8Nephronophthisis (HP:0000090)3.21783348
93-Methylglutaconic aciduria (HP:0003535)3.16119564
10Congenital stationary night blindness (HP:0007642)3.02422850
11Volvulus (HP:0002580)2.92589708
12Congenital, generalized hypertrichosis (HP:0004540)2.91479471
13Abnormality of the labia minora (HP:0012880)2.88992777
14Abnormality of the renal medulla (HP:0100957)2.85220321
15Acute necrotizing encephalopathy (HP:0006965)2.83702933
16Aplastic anemia (HP:0001915)2.81978796
17Mitochondrial inheritance (HP:0001427)2.79839713
18IgG deficiency (HP:0004315)2.76733651
19Abnormality of the ileum (HP:0001549)2.72320049
20Optic neuritis (HP:0100653)2.70304723
21Retrobulbar optic neuritis (HP:0100654)2.70304723
22Meckel diverticulum (HP:0002245)2.68947203
23Abolished electroretinogram (ERG) (HP:0000550)2.68890683
24Shawl scrotum (HP:0000049)2.68713135
25Increased CSF lactate (HP:0002490)2.63359489
26Abnormality of the renal cortex (HP:0011035)2.56320376
27Nephroblastoma (Wilms tumor) (HP:0002667)2.54817549
28Progressive macrocephaly (HP:0004481)2.49404609
29Abnormality of the preputium (HP:0100587)2.49338983
30Recurrent fungal infections (HP:0002841)2.46381944
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.43820058
32Febrile seizures (HP:0002373)2.43410995
33Recurrent cutaneous fungal infections (HP:0011370)2.43141381
34Chronic mucocutaneous candidiasis (HP:0002728)2.43141381
35Abnormality of T cell number (HP:0011839)2.40374514
36Abnormal mitochondria in muscle tissue (HP:0008316)2.40209650
37Embryonal renal neoplasm (HP:0011794)2.40026084
3811 pairs of ribs (HP:0000878)2.39348215
39Abnormal hair whorl (HP:0010721)2.37062997
40Elevated erythrocyte sedimentation rate (HP:0003565)2.35433320
41Myositis (HP:0100614)2.34851329
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.32736152
43Birth length less than 3rd percentile (HP:0003561)2.30015029
44T lymphocytopenia (HP:0005403)2.29049355
45Patellar aplasia (HP:0006443)2.28422777
46Abnormal rod and cone electroretinograms (HP:0008323)2.28212538
47Encephalitis (HP:0002383)2.27406871
48Type II lissencephaly (HP:0007260)2.27242139
49Polydipsia (HP:0001959)2.24845363
50Abnormal drinking behavior (HP:0030082)2.24845363
51Muscle fiber atrophy (HP:0100295)2.23863768
52Tubular atrophy (HP:0000092)2.22177670
53Acute encephalopathy (HP:0006846)2.20947656
54Abnormality of T cells (HP:0002843)2.20763285
55Reticulocytopenia (HP:0001896)2.17767238
56Hypochromic microcytic anemia (HP:0004840)2.17327845
57Large for gestational age (HP:0001520)2.17192010
58Hepatocellular necrosis (HP:0001404)2.14348175
59Absent radius (HP:0003974)2.14208953
60Type 2 muscle fiber atrophy (HP:0003554)2.13407815
61Abnormality of chromosome stability (HP:0003220)2.11581284
62Orchitis (HP:0100796)2.11044146
63Myelodysplasia (HP:0002863)2.10556881
64Stomach cancer (HP:0012126)2.10112206
65Cystic liver disease (HP:0006706)2.09620532
66Lipid accumulation in hepatocytes (HP:0006561)2.09349678
67Aplasia/Hypoplasia of the patella (HP:0006498)2.09053737
68Panhypogammaglobulinemia (HP:0003139)2.08705189
69Aplasia involving forearm bones (HP:0009822)2.05915963
70Absent forearm bone (HP:0003953)2.05915963
71Increased hepatocellular lipid droplets (HP:0006565)2.05785068
72Agitation (HP:0000713)2.05190431
73Abnormality of the phalanges of the hallux (HP:0010057)2.04993065
74Oligodactyly (hands) (HP:0001180)2.04494880
75Rib fusion (HP:0000902)2.04165046
76Triphalangeal thumb (HP:0001199)2.03935249
77Broad-based gait (HP:0002136)2.01552601
78Constricted visual fields (HP:0001133)2.01498669
79Shoulder girdle muscle weakness (HP:0003547)2.01404172
80Severe combined immunodeficiency (HP:0004430)2.01362786
81Chronic hepatic failure (HP:0100626)2.01206325
82Keratoconjunctivitis (HP:0001096)1.99958814
83Methylmalonic acidemia (HP:0002912)1.98972716
84Absent/shortened dynein arms (HP:0200106)1.98592121
85Dynein arm defect of respiratory motile cilia (HP:0012255)1.98592121
86Hepatic necrosis (HP:0002605)1.98359262
87Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95361690
88Abnormality of the incisor (HP:0000676)1.94914416
89Hypothermia (HP:0002045)1.94696175
90Hyperventilation (HP:0002883)1.94368074
91Premature graying of hair (HP:0002216)1.94364024
92Septo-optic dysplasia (HP:0100842)1.91236369
93Abnormal number of incisors (HP:0011064)1.91160190
94Optic disc pallor (HP:0000543)1.90635736
95Sclerocornea (HP:0000647)1.89865880
96Inability to walk (HP:0002540)1.89848717
97Exertional dyspnea (HP:0002875)1.88797697
98Pulmonary infiltrates (HP:0002113)1.88454144
99Abnormality of eosinophils (HP:0001879)1.88440964
100Abnormality of cells of the erythroid lineage (HP:0012130)1.88330637
101Furrowed tongue (HP:0000221)1.87188403
102Polyuria (HP:0000103)1.86479028
103Abnormality of B cell number (HP:0010975)1.85825232
104Pendular nystagmus (HP:0012043)1.85199305
105Intestinal atresia (HP:0011100)1.84837472
106Hemoptysis (HP:0002105)1.84241371
107Attenuation of retinal blood vessels (HP:0007843)1.83316857
108Bile duct proliferation (HP:0001408)1.82939788
109Abnormal biliary tract physiology (HP:0012439)1.82939788
110Median cleft lip (HP:0000161)1.82606934
111Colon cancer (HP:0003003)1.82418160
112Epileptic encephalopathy (HP:0200134)1.82369522
113Missing ribs (HP:0000921)1.81566095
114Focal motor seizures (HP:0011153)1.81191547
115Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.81126221
116Abnormal lung lobation (HP:0002101)1.80283390
117Asplenia (HP:0001746)1.79550915
118Abnormal number of erythroid precursors (HP:0012131)1.78724047
119Hypochromic anemia (HP:0001931)1.78514011
120Horseshoe kidney (HP:0000085)1.78258673
121Pallor (HP:0000980)1.76198003
122Abnormality of T cell physiology (HP:0011840)1.74894717
123Hypomagnesemia (HP:0002917)1.74734688
124Increased serum lactate (HP:0002151)1.74484943
125Aplasia/Hypoplasia of the tibia (HP:0005772)1.73901804
126Small intestinal stenosis (HP:0012848)1.73869482
127Duodenal stenosis (HP:0100867)1.73869482
128Progressive inability to walk (HP:0002505)1.73795671
129Abnormality of the pons (HP:0007361)1.73691199
130Breast hypoplasia (HP:0003187)1.73427265
131Thyroiditis (HP:0100646)1.73242183
132Atonic seizures (HP:0010819)1.73087419
133Protruding tongue (HP:0010808)1.72763047
134Absent thumb (HP:0009777)1.72041636
135Meningitis (HP:0001287)1.70612413
136Methylmalonic aciduria (HP:0012120)1.69455654
137Pustule (HP:0200039)1.69171940
138Rectovaginal fistula (HP:0000143)1.68578717
139Rectal fistula (HP:0100590)1.68578717
140Intestinal fistula (HP:0100819)1.68263534
141Gaze-evoked nystagmus (HP:0000640)1.67911241
142Severe muscular hypotonia (HP:0006829)1.67766351
143Abnormal respiratory epithelium morphology (HP:0012253)1.67610590
144Abnormal respiratory motile cilium morphology (HP:0005938)1.67610590
145Concave nail (HP:0001598)1.66526129
146Pelvic girdle muscle weakness (HP:0003749)1.65536302
147Acute lymphatic leukemia (HP:0006721)1.62145570
148Aplasia/Hypoplasia of the spleen (HP:0010451)1.60992733
149Optic nerve hypoplasia (HP:0000609)1.59935136
150Abnormality of the columella (HP:0009929)1.59800533
151Preaxial hand polydactyly (HP:0001177)1.59779556
152Pancreatic fibrosis (HP:0100732)1.58965619
153Supernumerary bones of the axial skeleton (HP:0009144)1.58073636
154True hermaphroditism (HP:0010459)1.57921122
155Ectopic kidney (HP:0000086)1.57898744
156Aganglionic megacolon (HP:0002251)1.57260120
157Medial flaring of the eyebrow (HP:0010747)1.56673965
158Irregular epiphyses (HP:0010582)1.55601569
159Cleft eyelid (HP:0000625)1.55523895
160Abnormality of the nasal septum (HP:0000419)1.55182942
161Limb dystonia (HP:0002451)1.53835450
162Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.53434147
163Short tibia (HP:0005736)1.53165310
164Supernumerary ribs (HP:0005815)1.51922803
165Neuroblastoma (HP:0003006)1.51684571
166Primitive neuroectodermal tumor (HP:0030065)1.51684571
167Neuroblastic tumors (HP:0004376)1.51684571
168Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.51684571
169Duplicated collecting system (HP:0000081)1.51222771
170Increased IgM level (HP:0003496)1.50514148
171Prostate neoplasm (HP:0100787)1.50318615
172Tracheoesophageal fistula (HP:0002575)1.49702112
173Male pseudohermaphroditism (HP:0000037)1.49435810
174Abnormality of incisor morphology (HP:0011063)1.48724901
175Abnormality of the musculature of the pelvis (HP:0001469)1.48293196
176Abnormality of the hip-girdle musculature (HP:0001445)1.48293196
177Clubbing of toes (HP:0100760)1.48146887
178Abnormality of the renal collecting system (HP:0004742)1.46215159
179Aplasia/Hypoplasia of the fovea (HP:0008060)1.46062360
180Hypoplasia of the fovea (HP:0007750)1.46062360
181Gait imbalance (HP:0002141)1.45499372
182Medulloblastoma (HP:0002885)1.44718016
183Abnormality of the septum pellucidum (HP:0007375)1.44523256
184Hypoplastic iliac wings (HP:0002866)1.44106068
185Tetralogy of Fallot (HP:0001636)1.44034420
186Fibular hypoplasia (HP:0003038)1.43732078
187Sex reversal (HP:0012245)1.43265927
188Abnormal sex determination (HP:0012244)1.43265927

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.09802205
2TAOK33.04932694
3CASK3.04785938
4PNCK3.01847927
5MKNK22.92338451
6MAP4K12.66507573
7CDC72.58284867
8WEE12.53801149
9CDK122.49871315
10MKNK12.44199245
11GRK12.09835189
12ACVR1B2.08395182
13STK38L2.06306654
14SRPK12.00589932
15CDK81.98299445
16SIK31.97785176
17BMPR21.92041292
18PLK21.90480444
19WNK41.90200566
20MAP2K71.89921238
21RIPK41.88249458
22NTRK31.86875829
23NUAK11.78598548
24MAP4K21.75936674
25BRSK21.72918516
26BRD41.69525014
27AKT31.65123115
28MAP3K121.62849807
29PAK31.62325715
30PASK1.57554956
31ZAK1.57529864
32CDK71.56067234
33MAP3K41.54959100
34PLK11.53827351
35IKBKB1.46407626
36CAMKK21.44407618
37TSSK61.44279002
38PLK31.44106620
39GRK61.42915766
40ITK1.41646320
41GRK51.36726288
42TLK11.36203818
43SYK1.35626734
44VRK11.34357703
45TNIK1.33863944
46TGFBR11.31007116
47LATS21.27417307
48CHEK21.27012634
49DAPK21.26908130
50PINK11.26738719
51FES1.24219907
52YES11.23919325
53TNK21.21612144
54EIF2AK21.20264337
55MAP2K61.18378411
56ATR1.17553646
57IKBKE1.16020862
58PLK41.15740122
59PRKCQ1.10333304
60DAPK11.08377043
61TTK1.08287006
62NEK21.07084486
63BUB11.06883632
64OXSR11.05027486
65TEC1.03293855
66CAMKK11.03018685
67MAP3K141.01995785
68BRSK10.97174862
69IRAK10.95800130
70IRAK40.95063282
71ADRBK20.94747480
72BTK0.94145994
73LYN0.93990519
74KIT0.92431794
75ATM0.91427825
76LCK0.91411275
77EIF2AK10.90450953
78STK240.89923351
79NEK10.88511536
80MAPK150.88480193
81CSF1R0.88334056
82AURKB0.88063450
83CSK0.86859748
84INSRR0.86007512
85CHEK10.85620534
86TYK20.85147859
87ADRBK10.83924661
88AURKA0.83558662
89SIK20.80503599
90KSR10.77138183
91TRIM280.75856350
92BCKDK0.75418477
93MST40.75109613
94NTRK20.75063158
95GRK70.75027591
96CDK20.75015322
97BMPR1B0.73089930
98MINK10.72935296
99PIK3CG0.70142437
100MAPK100.68858121
101NME10.68386517
102MAPK130.68051339
103NLK0.67787209
104DYRK30.65694518
105CSNK2A10.65365349
106TXK0.62038960
107CHUK0.61961146
108CDK10.61516432
109STK160.61505128
110STK390.58806075
111RPS6KB10.58673625
112ZAP700.57776599
113MAP3K130.56769846
114CDK90.56281835
115CSNK2A20.56083960
116MAPK140.55594820
117MAP3K110.55472599
118PIK3CA0.55110119
119MAP3K60.54466344
120HCK0.53360828
121BCR0.51066628
122PHKG10.51004486
123PHKG20.51004486
124EPHA20.50904677
125PKN10.49400977
126CSNK1E0.48985796
127IRAK30.48718318
128NME20.48072922
129DYRK1A0.47039125
130CAMK10.46702257
131ALK0.46696621
132PRKCG0.46312786
133PTK2B0.45904224
134PRKD20.45710446
135JAK10.43626427
136PIM20.43312367
137UHMK10.43110732
138MAPKAPK30.43075523
139RAF10.42591993
140FLT30.42584189
141PRKDC0.42437770
142GSK3B0.42320815
143CDK40.42114529
144PIM10.41454757
145EPHA30.41442510
146TBK10.41110908
147PRKG10.40752960
148CDK30.40133186
149PRKCI0.38218529
150RPS6KA50.37826445
151MARK30.37644678
152RPS6KA40.37376116
153PRKCE0.37249066
154DYRK20.36845909
155TIE10.35988192
156MAPK90.35890933
157CAMK2A0.35264797
158PRKACA0.35204322
159MATK0.34429327
160BLK0.33139219
161STK110.32994262
162AKT10.32412984
163CCNB10.30839066
164JAK20.30255485
165JAK30.30242652
166CDK190.30077951
167WNK30.29537811
168FGR0.29079099

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.01700961
2Graft-versus-host disease_Homo sapiens_hsa053322.67919543
3Mismatch repair_Homo sapiens_hsa034302.60661757
4DNA replication_Homo sapiens_hsa030302.48540860
5Homologous recombination_Homo sapiens_hsa034402.41590725
6Spliceosome_Homo sapiens_hsa030402.40556705
7Asthma_Homo sapiens_hsa053102.35475760
8Ribosome_Homo sapiens_hsa030102.32455278
9RNA polymerase_Homo sapiens_hsa030202.29048982
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.14524733
11Basal transcription factors_Homo sapiens_hsa030222.08247895
12RNA transport_Homo sapiens_hsa030131.99703578
13Base excision repair_Homo sapiens_hsa034101.97133682
14Fanconi anemia pathway_Homo sapiens_hsa034601.94726426
15Cell cycle_Homo sapiens_hsa041101.87936104
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.78246523
17Nucleotide excision repair_Homo sapiens_hsa034201.71950652
18RNA degradation_Homo sapiens_hsa030181.68871256
19Non-homologous end-joining_Homo sapiens_hsa034501.68233469
20mRNA surveillance pathway_Homo sapiens_hsa030151.67416905
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61956984
22Nicotine addiction_Homo sapiens_hsa050331.60845024
23Proteasome_Homo sapiens_hsa030501.60209036
24Selenocompound metabolism_Homo sapiens_hsa004501.59912751
25Antigen processing and presentation_Homo sapiens_hsa046121.55347991
26Rheumatoid arthritis_Homo sapiens_hsa053231.53422592
27Nitrogen metabolism_Homo sapiens_hsa009101.51975106
28Linoleic acid metabolism_Homo sapiens_hsa005911.45427274
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44388068
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.39641344
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26651610
32Serotonergic synapse_Homo sapiens_hsa047261.24123725
33Pyrimidine metabolism_Homo sapiens_hsa002401.23092568
34Caffeine metabolism_Homo sapiens_hsa002321.21138241
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14339784
36Leishmaniasis_Homo sapiens_hsa051401.13499105
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13256504
38Staphylococcus aureus infection_Homo sapiens_hsa051501.12912656
39Oocyte meiosis_Homo sapiens_hsa041141.10859665
40Taste transduction_Homo sapiens_hsa047421.09264155
41Ether lipid metabolism_Homo sapiens_hsa005651.06320955
42Protein export_Homo sapiens_hsa030601.05442708
43p53 signaling pathway_Homo sapiens_hsa041151.05413852
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03136763
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02880991
46Regulation of autophagy_Homo sapiens_hsa041401.02404744
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01760653
48Huntingtons disease_Homo sapiens_hsa050161.00634941
49Amphetamine addiction_Homo sapiens_hsa050311.00528232
50Synaptic vesicle cycle_Homo sapiens_hsa047210.97682172
51Tryptophan metabolism_Homo sapiens_hsa003800.96281317
52Oxidative phosphorylation_Homo sapiens_hsa001900.95882376
53Butanoate metabolism_Homo sapiens_hsa006500.95002555
54Long-term potentiation_Homo sapiens_hsa047200.93592601
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93056790
56Epstein-Barr virus infection_Homo sapiens_hsa051690.92835984
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92383756
58Wnt signaling pathway_Homo sapiens_hsa043100.91944716
59Long-term depression_Homo sapiens_hsa047300.90452137
60Parkinsons disease_Homo sapiens_hsa050120.87829861
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86956756
62One carbon pool by folate_Homo sapiens_hsa006700.84893458
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84501098
64Peroxisome_Homo sapiens_hsa041460.83415749
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83174623
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83091532
67Morphine addiction_Homo sapiens_hsa050320.82623841
68Purine metabolism_Homo sapiens_hsa002300.80927599
69Sulfur relay system_Homo sapiens_hsa041220.79509405
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77438409
71Dopaminergic synapse_Homo sapiens_hsa047280.76740159
72Tuberculosis_Homo sapiens_hsa051520.76432500
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75898932
74TGF-beta signaling pathway_Homo sapiens_hsa043500.74650955
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74382931
76HTLV-I infection_Homo sapiens_hsa051660.73624883
77Herpes simplex infection_Homo sapiens_hsa051680.73616741
78Thyroid cancer_Homo sapiens_hsa052160.72178073
79Osteoclast differentiation_Homo sapiens_hsa043800.69900841
80MicroRNAs in cancer_Homo sapiens_hsa052060.69091861
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.68866001
82Collecting duct acid secretion_Homo sapiens_hsa049660.68536522
83Olfactory transduction_Homo sapiens_hsa047400.68298744
84Hippo signaling pathway_Homo sapiens_hsa043900.68118229
85B cell receptor signaling pathway_Homo sapiens_hsa046620.68042585
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67814745
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67442454
88Glutamatergic synapse_Homo sapiens_hsa047240.64225744
89Colorectal cancer_Homo sapiens_hsa052100.63393409
90Circadian entrainment_Homo sapiens_hsa047130.63313782
91Melanoma_Homo sapiens_hsa052180.62850529
92GABAergic synapse_Homo sapiens_hsa047270.62810861
93Melanogenesis_Homo sapiens_hsa049160.61386600
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60906848
95Chemokine signaling pathway_Homo sapiens_hsa040620.59738383
96Alzheimers disease_Homo sapiens_hsa050100.58775757
97Basal cell carcinoma_Homo sapiens_hsa052170.58392646
98Hedgehog signaling pathway_Homo sapiens_hsa043400.58029147
99Cocaine addiction_Homo sapiens_hsa050300.56535649
100Allograft rejection_Homo sapiens_hsa053300.56091925
101Arachidonic acid metabolism_Homo sapiens_hsa005900.55939013
102African trypanosomiasis_Homo sapiens_hsa051430.55885633
103Type I diabetes mellitus_Homo sapiens_hsa049400.54906608
104ErbB signaling pathway_Homo sapiens_hsa040120.54844750
105Adherens junction_Homo sapiens_hsa045200.53742480
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51872198
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51475952
108Hematopoietic cell lineage_Homo sapiens_hsa046400.50083802
109Phototransduction_Homo sapiens_hsa047440.49162198
110Pathways in cancer_Homo sapiens_hsa052000.49034196
111MAPK signaling pathway_Homo sapiens_hsa040100.49013657
112Oxytocin signaling pathway_Homo sapiens_hsa049210.49010538
113Vibrio cholerae infection_Homo sapiens_hsa051100.48810792
114Hepatitis B_Homo sapiens_hsa051610.48731140
115Cholinergic synapse_Homo sapiens_hsa047250.48645944
116Autoimmune thyroid disease_Homo sapiens_hsa053200.48617406
117Calcium signaling pathway_Homo sapiens_hsa040200.48510678
118Cardiac muscle contraction_Homo sapiens_hsa042600.48167326
119Alcoholism_Homo sapiens_hsa050340.48125910
120Primary immunodeficiency_Homo sapiens_hsa053400.46570194
121GnRH signaling pathway_Homo sapiens_hsa049120.46518631
122Dorso-ventral axis formation_Homo sapiens_hsa043200.46181454
123Phagosome_Homo sapiens_hsa041450.46010595
124Renin secretion_Homo sapiens_hsa049240.45097455
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.44915835
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44381626
127Measles_Homo sapiens_hsa051620.43891781
128Prostate cancer_Homo sapiens_hsa052150.43020045
129Insulin secretion_Homo sapiens_hsa049110.42654612
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41751848
131TNF signaling pathway_Homo sapiens_hsa046680.41691285
132Viral carcinogenesis_Homo sapiens_hsa052030.41317302
133Ras signaling pathway_Homo sapiens_hsa040140.41220369
134Glioma_Homo sapiens_hsa052140.41173512
135Gap junction_Homo sapiens_hsa045400.40987285
136ABC transporters_Homo sapiens_hsa020100.40982716
137Choline metabolism in cancer_Homo sapiens_hsa052310.39867174
138Chemical carcinogenesis_Homo sapiens_hsa052040.39854604
139Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39335255
140Intestinal immune network for IgA production_Homo sapiens_hsa046720.38167605
141Malaria_Homo sapiens_hsa051440.38007947
142Legionellosis_Homo sapiens_hsa051340.37892741
143T cell receptor signaling pathway_Homo sapiens_hsa046600.37787202
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37736419
145Shigellosis_Homo sapiens_hsa051310.37059299
146Rap1 signaling pathway_Homo sapiens_hsa040150.36978740
147Viral myocarditis_Homo sapiens_hsa054160.33775245
148Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31580408
149Ovarian steroidogenesis_Homo sapiens_hsa049130.30917635
150Salivary secretion_Homo sapiens_hsa049700.30438865
151Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29619839
152Mineral absorption_Homo sapiens_hsa049780.29087449
153Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25817552
154Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23774456

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