ZSCAN12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)4.53618935
2sperm-egg recognition (GO:0035036)4.52993682
3nuclear pore organization (GO:0006999)4.18627461
4fusion of sperm to egg plasma membrane (GO:0007342)4.17436454
5DNA unwinding involved in DNA replication (GO:0006268)4.15498333
6cell-cell recognition (GO:0009988)4.05556321
7DNA double-strand break processing (GO:0000729)4.02219144
8protein localization to kinetochore (GO:0034501)3.87825260
9response to pheromone (GO:0019236)3.85287736
10ribosomal small subunit assembly (GO:0000028)3.83925800
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.83887430
12purine nucleobase biosynthetic process (GO:0009113)3.82926969
13monoubiquitinated protein deubiquitination (GO:0035520)3.81335031
14nuclear pore complex assembly (GO:0051292)3.80453181
15mitotic nuclear envelope disassembly (GO:0007077)3.79873428
16cilium or flagellum-dependent cell motility (GO:0001539)3.75883931
17mitotic sister chromatid cohesion (GO:0007064)3.75462321
18protein localization to chromosome, centromeric region (GO:0071459)3.74914785
19nucleobase biosynthetic process (GO:0046112)3.72641780
20pyrimidine dimer repair (GO:0006290)3.67341892
21behavioral response to nicotine (GO:0035095)3.64617414
22intraciliary transport (GO:0042073)3.60867126
23neural tube formation (GO:0001841)3.59162398
24DNA replication initiation (GO:0006270)3.58454814
25cell wall macromolecule catabolic process (GO:0016998)3.56508038
26cell wall macromolecule metabolic process (GO:0044036)3.56508038
27mitotic metaphase plate congression (GO:0007080)3.51413635
28membrane disassembly (GO:0030397)3.51159777
29nuclear envelope disassembly (GO:0051081)3.51159777
30regulation of mitotic spindle checkpoint (GO:1903504)3.50750625
31regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.50750625
32maturation of SSU-rRNA (GO:0030490)3.48995129
33histone H2A acetylation (GO:0043968)3.47771933
34formation of translation preinitiation complex (GO:0001731)3.46449846
35positive regulation of mitochondrial fission (GO:0090141)3.45076678
36negative regulation of mitotic sister chromatid separation (GO:2000816)3.37012087
37negative regulation of mitotic sister chromatid segregation (GO:0033048)3.37012087
38negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.37012087
39negative regulation of sister chromatid segregation (GO:0033046)3.37012087
40pyrimidine nucleobase catabolic process (GO:0006208)3.36741496
41DNA replication-dependent nucleosome assembly (GO:0006335)3.35664928
42DNA replication-dependent nucleosome organization (GO:0034723)3.35664928
43multicellular organism reproduction (GO:0032504)3.35125062
44negative regulation of chromosome segregation (GO:0051985)3.34995046
45protein K6-linked ubiquitination (GO:0085020)3.33774431
46male meiosis (GO:0007140)3.33357701
47chaperone-mediated protein complex assembly (GO:0051131)3.33332196
48negative regulation of DNA repair (GO:0045738)3.32647170
49translesion synthesis (GO:0019985)3.31714217
50sperm motility (GO:0030317)3.31198980
51replication fork processing (GO:0031297)3.30465670
52protein prenylation (GO:0018342)3.28510049
53prenylation (GO:0097354)3.28510049
54ribosome biogenesis (GO:0042254)3.27691954
55attachment of spindle microtubules to kinetochore (GO:0008608)3.27600667
56acrosome assembly (GO:0001675)3.27353933
57negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.27315557
58piRNA metabolic process (GO:0034587)3.24906305
59mitotic spindle assembly checkpoint (GO:0007094)3.23241259
60regulation of nuclear cell cycle DNA replication (GO:0033262)3.22298486
61synaptonemal complex assembly (GO:0007130)3.20903813
62spindle assembly checkpoint (GO:0071173)3.19981823
63folic acid-containing compound biosynthetic process (GO:0009396)3.19519555
64DNA strand elongation involved in DNA replication (GO:0006271)3.18670479
65regulation of chromosome segregation (GO:0051983)3.17755554
66metaphase plate congression (GO:0051310)3.17740761
67rRNA catabolic process (GO:0016075)3.15661776
68translational termination (GO:0006415)3.15150793
69viral transcription (GO:0019083)3.15017890
70establishment of integrated proviral latency (GO:0075713)3.13524023
71synaptonemal complex organization (GO:0070193)3.13414016
72DNA strand elongation (GO:0022616)3.10181326
73postreplication repair (GO:0006301)3.10006480
74negative regulation of DNA-dependent DNA replication (GO:2000104)3.08393291
75seminiferous tubule development (GO:0072520)3.05506217
76DNA replication checkpoint (GO:0000076)3.05184408
77IMP biosynthetic process (GO:0006188)3.04283303
78DNA duplex unwinding (GO:0032508)3.03556548
79mitotic spindle checkpoint (GO:0071174)3.03102709
80DNA geometric change (GO:0032392)3.03072469
81regulation of histone H3-K9 methylation (GO:0051570)3.03004837
82regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01714113
83protein localization to chromosome (GO:0034502)3.01592836
84somatic hypermutation of immunoglobulin genes (GO:0016446)3.00247303
85somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00247303
86histone exchange (GO:0043486)3.00158830
87spindle checkpoint (GO:0031577)2.99644272
88regulation of spindle organization (GO:0090224)2.99414029
89translational elongation (GO:0006414)2.98489271
90ncRNA catabolic process (GO:0034661)2.96651819
91plasma membrane fusion (GO:0045026)2.96338999
92spermatid development (GO:0007286)2.96237266
93pore complex assembly (GO:0046931)2.96027864
94regulation of sister chromatid segregation (GO:0033045)2.95735969
95regulation of mitotic sister chromatid separation (GO:0010965)2.95735969
96regulation of mitotic sister chromatid segregation (GO:0033047)2.95735969
97motile cilium assembly (GO:0044458)2.95150509
98regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.95023566
99translational initiation (GO:0006413)2.94915423
100regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.94859821
101protein-cofactor linkage (GO:0018065)2.94591801
102recombinational repair (GO:0000725)2.94142919
103water-soluble vitamin biosynthetic process (GO:0042364)2.94122583
104negative regulation of DNA recombination (GO:0045910)2.93345090
105chromosome condensation (GO:0030261)2.92696121
106IMP metabolic process (GO:0046040)2.92513339
107double-strand break repair via homologous recombination (GO:0000724)2.91124990
108ubiquinone metabolic process (GO:0006743)2.90245715
109rRNA modification (GO:0000154)2.90186338
110regulation of DNA endoreduplication (GO:0032875)2.89958338
111chromatin remodeling at centromere (GO:0031055)2.89622436
112mitotic chromosome condensation (GO:0007076)2.88418972
113ribonucleoprotein complex biogenesis (GO:0022613)2.88326914
114gene silencing by RNA (GO:0031047)2.88285622
115ribosome assembly (GO:0042255)2.87158458
116protein K11-linked deubiquitination (GO:0035871)2.86779118
117DNA deamination (GO:0045006)2.86219996
118nucleobase catabolic process (GO:0046113)2.84859871
119regulation of RNA export from nucleus (GO:0046831)2.84219950
120rRNA methylation (GO:0031167)2.84135056
121regulation of translation, ncRNA-mediated (GO:0045974)2.83299225
122negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.83299225
123negative regulation of translation, ncRNA-mediated (GO:0040033)2.83299225
124kinetochore organization (GO:0051383)2.82915632
125fucose catabolic process (GO:0019317)2.82783891
126L-fucose metabolic process (GO:0042354)2.82783891
127L-fucose catabolic process (GO:0042355)2.82783891
128somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.82525824
129somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.82525824
130isotype switching (GO:0045190)2.82525824
131telomere maintenance via semi-conservative replication (GO:0032201)2.82432463
132regulation of centrosome cycle (GO:0046605)2.82299081
133meiotic chromosome segregation (GO:0045132)2.81417648
134DNA replication-independent nucleosome organization (GO:0034724)2.80867253
135DNA replication-independent nucleosome assembly (GO:0006336)2.80867253
136regulation of centriole replication (GO:0046599)2.80290320
137RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.80219249
138exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79295516
139cullin deneddylation (GO:0010388)2.78463083
140nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.77113665
141protein polyglutamylation (GO:0018095)2.75794260
142reciprocal DNA recombination (GO:0035825)2.72863612
143reciprocal meiotic recombination (GO:0007131)2.72863612
144photoreceptor cell maintenance (GO:0045494)2.71027978
145kidney morphogenesis (GO:0060993)2.69276414
146nonmotile primary cilium assembly (GO:0035058)2.65945384
147ubiquinone biosynthetic process (GO:0006744)2.65203088
148maturation of 5.8S rRNA (GO:0000460)2.65083528
149maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.64456661
150DNA damage response, detection of DNA damage (GO:0042769)2.64406188
151preassembly of GPI anchor in ER membrane (GO:0016254)2.60870798
152presynaptic membrane assembly (GO:0097105)2.60351482
153regulation of cilium movement (GO:0003352)2.60167109
154mismatch repair (GO:0006298)2.59569112
155protein localization to cilium (GO:0061512)2.58888393
156respiratory chain complex IV assembly (GO:0008535)2.58540448
157cilium morphogenesis (GO:0060271)2.57744868
158somatic diversification of immunoglobulins (GO:0016445)2.54208778
159centriole replication (GO:0007099)2.54122047
160protein deneddylation (GO:0000338)2.53913118
161hindbrain development (GO:0030902)2.53044458
162somite rostral/caudal axis specification (GO:0032525)2.52111235
163regulation of glucokinase activity (GO:0033131)2.51849716
164regulation of hexokinase activity (GO:1903299)2.51849716
165resolution of meiotic recombination intermediates (GO:0000712)2.51047585
166DNA catabolic process, exonucleolytic (GO:0000738)2.47801008
167somatic recombination of immunoglobulin gene segments (GO:0016447)2.47447566
168DNA demethylation (GO:0080111)2.45949898
169organelle disassembly (GO:1903008)2.45148349
170peptidyl-histidine modification (GO:0018202)2.43775640
171regulation of telomere maintenance (GO:0032204)2.43231496
172negative regulation of neurological system process (GO:0031645)2.42378440
173CENP-A containing nucleosome assembly (GO:0034080)2.40729826
174synapsis (GO:0007129)2.40188231
175regulation of centrosome duplication (GO:0010824)2.39651282
176mitochondrial RNA metabolic process (GO:0000959)2.39553575
177nucleotide-excision repair, DNA gap filling (GO:0006297)2.39522637
178pseudouridine synthesis (GO:0001522)2.39304485
179platelet dense granule organization (GO:0060155)2.38962025
180limb bud formation (GO:0060174)2.38129315
181cytochrome complex assembly (GO:0017004)2.37131096
182RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.37100916
183tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.37100916
184mitochondrial respiratory chain complex assembly (GO:0033108)2.36943598
185epithelial cilium movement (GO:0003351)2.36894372
186negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.36799609

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.18515129
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.51064577
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.25615387
4ZNF274_21170338_ChIP-Seq_K562_Hela4.14493972
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.71097743
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58207931
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46699274
8IGF1R_20145208_ChIP-Seq_DFB_Human3.07223514
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.95075628
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.86250962
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.78218770
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74944118
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74667475
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68262586
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.60659375
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.56034391
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.50147095
18GBX2_23144817_ChIP-Seq_PC3_Human2.46191699
19EWS_26573619_Chip-Seq_HEK293_Human2.45877866
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.44557072
21* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43568974
22AR_21909140_ChIP-Seq_LNCAP_Human2.42874002
23FUS_26573619_Chip-Seq_HEK293_Human2.42028524
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40594641
25VDR_22108803_ChIP-Seq_LS180_Human2.39539308
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.38573754
27* XRN2_22483619_ChIP-Seq_HELA_Human2.34465053
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33440518
29TAF15_26573619_Chip-Seq_HEK293_Human2.29275842
30ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27188879
31RBPJ_22232070_ChIP-Seq_NCS_Mouse2.22146204
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17877095
33* VDR_23849224_ChIP-Seq_CD4+_Human2.12236591
34CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12128120
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11706604
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06542101
37IRF1_19129219_ChIP-ChIP_H3396_Human2.00581911
38MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00501572
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.99084481
40GABP_19822575_ChIP-Seq_HepG2_Human1.97834803
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91818111
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91660329
43FOXP3_21729870_ChIP-Seq_TREG_Human1.90898952
44P300_19829295_ChIP-Seq_ESCs_Human1.88928300
45DCP1A_22483619_ChIP-Seq_HELA_Human1.88336108
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.84266554
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.82731146
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80566979
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80451820
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80342791
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79777888
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.79240051
53TTF2_22483619_ChIP-Seq_HELA_Human1.76828927
54* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76142567
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75470943
56CIITA_25753668_ChIP-Seq_RAJI_Human1.74393672
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73568314
58ELK1_19687146_ChIP-ChIP_HELA_Human1.70843161
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70693709
60CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.67565080
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67407303
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.67232565
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62436997
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56714966
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56646104
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55914108
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55485826
68MYC_22102868_ChIP-Seq_BL_Human1.54728314
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53724752
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52867412
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47902443
72ER_23166858_ChIP-Seq_MCF-7_Human1.47023559
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46902219
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44949671
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.44893257
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44726687
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44207559
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43598506
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42847156
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37507144
81KDM5A_27292631_Chip-Seq_BREAST_Human1.37109333
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37046473
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36690480
84* CBP_20019798_ChIP-Seq_JUKART_Human1.36670068
85* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36670068
86* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36531631
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31884886
88STAT3_23295773_ChIP-Seq_U87_Human1.30997816
89* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30879921
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30575006
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29488093
92MYC_18940864_ChIP-ChIP_HL60_Human1.29430158
93* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28762721
94RNF2_27304074_Chip-Seq_NSC_Mouse1.27658528
95SMAD4_21799915_ChIP-Seq_A2780_Human1.26614228
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25820824
97TP63_19390658_ChIP-ChIP_HaCaT_Human1.25308884
98TP53_22573176_ChIP-Seq_HFKS_Human1.24928579
99EZH2_22144423_ChIP-Seq_EOC_Human1.24628442
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23714028
101SOX2_16153702_ChIP-ChIP_HESCs_Human1.21601440
102PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21561017
103NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21387473
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21323733
105CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19541235
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18925055
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18488189
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16592159
109CBX2_27304074_Chip-Seq_ESCs_Mouse1.14467648
110TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13118592
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12728893
112PIAS1_25552417_ChIP-Seq_VCAP_Human1.12670619
113YY1_21170310_ChIP-Seq_MESCs_Mouse1.12069674
114SALL1_21062744_ChIP-ChIP_HESCs_Human1.10331720
115STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10034520
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09823934
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09544910
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07811290
119SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07794078
120BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07693218
121TCF4_23295773_ChIP-Seq_U87_Human1.07416385
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06800868
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06797177
124NANOG_18555785_Chip-Seq_ESCs_Mouse1.06240857
125SMAD3_21741376_ChIP-Seq_EPCs_Human1.06207507
126NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05472580
127SCL_19346495_ChIP-Seq_HPC-7_Human1.05221268
128CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04515204
129EZH2_27294783_Chip-Seq_NPCs_Mouse1.04445117
130PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04358785
131* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03329531
132DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03005115
133* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02896433
134POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02736136
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01210529
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01210529
137NFE2_27457419_Chip-Seq_LIVER_Mouse1.01027727
138AR_25329375_ChIP-Seq_VCAP_Human1.00107829
139PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00013827
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99366381
141TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98114752
142NCOR_22424771_ChIP-Seq_293T_Human0.98040210
143RUNX2_22187159_ChIP-Seq_PCA_Human0.95882555
144SOX2_19829295_ChIP-Seq_ESCs_Human0.95650251
145NANOG_19829295_ChIP-Seq_ESCs_Human0.95650251
146ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95178231
147* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94604432
148EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93799941
149TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93539943
150ZNF263_19887448_ChIP-Seq_K562_Human0.91733755
151SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90796602
152TFEB_21752829_ChIP-Seq_HELA_Human0.90653511
153SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90145820
154SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89188568
155NANOG_21062744_ChIP-ChIP_HESCs_Human0.88459201
156CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87801904
157PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86552125
158POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86522183
159NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.85430293
160CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83095685
161CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82209967
162SPI1_23547873_ChIP-Seq_NB4_Human0.80933844
163PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77466100
164SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74130459
165TBX5_21415370_ChIP-Seq_HL-1_Mouse0.73515538
166SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.73035745
167TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68892835
168HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.68148479
169CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.67152130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.85740260
2MP0010094_abnormal_chromosome_stability3.76111991
3MP0005410_abnormal_fertilization3.67148614
4MP0003693_abnormal_embryo_hatching3.62610018
5MP0004957_abnormal_blastocyst_morpholog3.49548755
6MP0003111_abnormal_nucleus_morphology3.10343797
7MP0003077_abnormal_cell_cycle3.05946218
8MP0008058_abnormal_DNA_repair2.90544112
9MP0003123_paternal_imprinting2.88001066
10MP0008057_abnormal_DNA_replication2.85331291
11MP0002396_abnormal_hematopoietic_system2.51134008
12MP0008007_abnormal_cellular_replicative2.50808168
13MP0010307_abnormal_tumor_latency2.43029685
14MP0001929_abnormal_gametogenesis2.32710433
15MP0006072_abnormal_retinal_apoptosis2.19372397
16MP0001730_embryonic_growth_arrest2.15986306
17MP0004808_abnormal_hematopoietic_stem2.09860802
18MP0002139_abnormal_hepatobiliary_system1.99733484
19MP0002210_abnormal_sex_determination1.97292802
20MP0001188_hyperpigmentation1.97275004
21MP0003698_abnormal_male_reproductive1.89517972
22MP0001984_abnormal_olfaction1.85519277
23MP0003195_calcinosis1.83976018
24MP0003806_abnormal_nucleotide_metabolis1.81524341
25MP0001529_abnormal_vocalization1.80153785
26MP0005253_abnormal_eye_physiology1.78312851
27MP0001145_abnormal_male_reproductive1.76083940
28MP0001545_abnormal_hematopoietic_system1.75794903
29MP0005397_hematopoietic_system_phenotyp1.75794903
30MP0004043_abnormal_pH_regulation1.74716653
31MP0010352_gastrointestinal_tract_polyps1.72962487
32MP0003121_genomic_imprinting1.72137427
33MP0009697_abnormal_copulation1.71547756
34MP0005551_abnormal_eye_electrophysiolog1.69017343
35MP0005645_abnormal_hypothalamus_physiol1.66529370
36MP0009046_muscle_twitch1.65913878
37MP0001672_abnormal_embryogenesis/_devel1.63995985
38MP0005380_embryogenesis_phenotype1.63995985
39MP0008932_abnormal_embryonic_tissue1.63625137
40MP0005499_abnormal_olfactory_system1.63477474
41MP0005394_taste/olfaction_phenotype1.63477474
42MP0001293_anophthalmia1.62879621
43MP0003567_abnormal_fetal_cardiomyocyte1.61083989
44MP0001697_abnormal_embryo_size1.58250315
45MP0000350_abnormal_cell_proliferation1.57726451
46MP0000653_abnormal_sex_gland1.56447165
47MP0001968_abnormal_touch/_nociception1.55114468
48MP0003984_embryonic_growth_retardation1.52469454
49MP0004147_increased_porphyrin_level1.51708241
50MP0002088_abnormal_embryonic_growth/wei1.50162153
51MP0001986_abnormal_taste_sensitivity1.50132692
52MP0008789_abnormal_olfactory_epithelium1.49666808
53MP0002751_abnormal_autonomic_nervous1.47890968
54MP0003786_premature_aging1.47461542
55MP0000778_abnormal_nervous_system1.46601069
56MP0005084_abnormal_gallbladder_morpholo1.46561443
57MP0004142_abnormal_muscle_tone1.45970959
58MP0002638_abnormal_pupillary_reflex1.44520361
59MP0002736_abnormal_nociception_after1.44497371
60MP0002080_prenatal_lethality1.43445160
61MP0002163_abnormal_gland_morphology1.41449759
62MP0000490_abnormal_crypts_of1.41028711
63MP0006276_abnormal_autonomic_nervous1.38310256
64MP0003880_abnormal_central_pattern1.37873411
65MP0000631_abnormal_neuroendocrine_gland1.37375626
66MP0006292_abnormal_olfactory_placode1.36507643
67MP0004197_abnormal_fetal_growth/weight/1.36094252
68MP0003937_abnormal_limbs/digits/tail_de1.35406733
69MP0000569_abnormal_digit_pigmentation1.35182264
70MP0002084_abnormal_developmental_patter1.33751570
71MP0002735_abnormal_chemical_nociception1.33127769
72MP0003718_maternal_effect1.31378128
73MP0005379_endocrine/exocrine_gland_phen1.31314283
74MP0003119_abnormal_digestive_system1.30297995
75MP0001853_heart_inflammation1.26777164
76MP0002085_abnormal_embryonic_tissue1.25451910
77MP0002086_abnormal_extraembryonic_tissu1.24971372
78MP0006054_spinal_hemorrhage1.24515865
79MP0003943_abnormal_hepatobiliary_system1.24103125
80MP0010030_abnormal_orbit_morphology1.23464625
81MP0002161_abnormal_fertility/fecundity1.21855589
82MP0003868_abnormal_feces_composition1.20836000
83MP0000313_abnormal_cell_death1.20273352
84MP0002837_dystrophic_cardiac_calcinosis1.20098507
85MP0001286_abnormal_eye_development1.18655575
86MP0000427_abnormal_hair_cycle1.18025763
87MP0005220_abnormal_exocrine_pancreas1.17330745
88MP0002160_abnormal_reproductive_system1.15983915
89MP0009745_abnormal_behavioral_response1.14947896
90MP0002019_abnormal_tumor_incidence1.14632661
91MP0002557_abnormal_social/conspecific_i1.10994945
92MP0005670_abnormal_white_adipose1.09759139
93MP0002184_abnormal_innervation1.09723561
94MP0003136_yellow_coat_color1.09122320
95MP0003221_abnormal_cardiomyocyte_apopto1.07420218
96MP0008872_abnormal_physiological_respon1.06947459
97MP0002653_abnormal_ependyma_morphology1.04960555
98MP0005187_abnormal_penis_morphology1.04543563
99MP0005391_vision/eye_phenotype1.03433041
100MP0002272_abnormal_nervous_system1.02640155
101MP0000358_abnormal_cell_content/1.02272947
102MP0002233_abnormal_nose_morphology1.02105566
103MP0009672_abnormal_birth_weight1.01577892
104MP0000537_abnormal_urethra_morphology1.01273908
105MP0002938_white_spotting0.99471510
106MP0006036_abnormal_mitochondrial_physio0.98762333
107MP0002282_abnormal_trachea_morphology0.97217413
108MP0003787_abnormal_imprinting0.97032575
109MP0005423_abnormal_somatic_nervous0.95792537
110MP0005195_abnormal_posterior_eye0.95663109
111MP0002752_abnormal_somatic_nervous0.95274136
112MP0002572_abnormal_emotion/affect_behav0.94722490
113MP0005386_behavior/neurological_phenoty0.94239332
114MP0004924_abnormal_behavior0.94239332
115MP0000516_abnormal_urinary_system0.93757977
116MP0005367_renal/urinary_system_phenotyp0.93757977
117MP0000049_abnormal_middle_ear0.92478642
118MP0001348_abnormal_lacrimal_gland0.92185673
119MP0003283_abnormal_digestive_organ0.91620307
120MP0003122_maternal_imprinting0.90406686
121MP0009333_abnormal_splenocyte_physiolog0.90116667
122MP0001119_abnormal_female_reproductive0.89640076
123MP0003763_abnormal_thymus_physiology0.89230159
124MP0000383_abnormal_hair_follicle0.88903262
125MP0001915_intracranial_hemorrhage0.88112501
126MP0001486_abnormal_startle_reflex0.87619012
127MP0000955_abnormal_spinal_cord0.87306236
128MP0000703_abnormal_thymus_morphology0.86422419
129MP0003315_abnormal_perineum_morphology0.86229994
130MP0006035_abnormal_mitochondrial_morpho0.85203088
131MP0002398_abnormal_bone_marrow0.83574144
132MP0003861_abnormal_nervous_system0.83188145
133MP0002138_abnormal_hepatobiliary_system0.83008675
134MP0004233_abnormal_muscle_weight0.82917533
135MP0002102_abnormal_ear_morphology0.81602010
136MP0002092_abnormal_eye_morphology0.80913966
137MP0004885_abnormal_endolymph0.80870637
138MP0000647_abnormal_sebaceous_gland0.80811260
139MP0008995_early_reproductive_senescence0.79720216
140MP0002722_abnormal_immune_system0.78348913
141MP0002067_abnormal_sensory_capabilities0.78253529
142MP0003011_delayed_dark_adaptation0.77761869
143MP0004133_heterotaxia0.76584765
144MP0002733_abnormal_thermal_nociception0.76344349
145MP0003646_muscle_fatigue0.76102115
146MP0003890_abnormal_embryonic-extraembry0.76047367
147MP0001324_abnormal_eye_pigmentation0.75910493
148MP0002882_abnormal_neuron_morphology0.75790357
149MP0000689_abnormal_spleen_morphology0.75770973
150MP0005085_abnormal_gallbladder_physiolo0.75362506
151MP0009278_abnormal_bone_marrow0.74146333
152MP0004084_abnormal_cardiac_muscle0.72909480
153MP0009384_cardiac_valve_regurgitation0.72418604
154MP0000598_abnormal_liver_morphology0.70835266
155MP0001764_abnormal_homeostasis0.69803030
156MP0005389_reproductive_system_phenotype0.69217099
157MP0000428_abnormal_craniofacial_morphol0.68701259
158MP0002234_abnormal_pharynx_morphology0.67149734
159MP0009053_abnormal_anal_canal0.67147698
160MP0005647_abnormal_sex_gland0.66059523
161MP0002928_abnormal_bile_duct0.65536493
162MP0003186_abnormal_redox_activity0.62596187

Predicted human phenotypes

RankGene SetZ-score
1Selective tooth agenesis (HP:0001592)5.33060754
2Supernumerary spleens (HP:0009799)4.82968707
3Absent/shortened dynein arms (HP:0200106)3.80391241
4Dynein arm defect of respiratory motile cilia (HP:0012255)3.80391241
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.76744816
6Gonadotropin excess (HP:0000837)3.61956192
7Colon cancer (HP:0003003)3.55918112
8Abnormal spermatogenesis (HP:0008669)3.49957176
9Abnormality of cells of the erythroid lineage (HP:0012130)3.24947840
10Chronic hepatic failure (HP:0100626)3.23105652
11Chronic bronchitis (HP:0004469)3.22471684
12Reticulocytopenia (HP:0001896)3.18996418
13Abnormal respiratory epithelium morphology (HP:0012253)3.11041967
14Abnormal respiratory motile cilium morphology (HP:0005938)3.11041967
15Abnormal number of erythroid precursors (HP:0012131)3.07342530
16Short middle phalanx of the 5th finger (HP:0004220)3.04961530
17Medial flaring of the eyebrow (HP:0010747)2.88522229
18Rhinitis (HP:0012384)2.84116392
19Abnormality of the renal medulla (HP:0100957)2.80319808
20Broad alveolar ridges (HP:0000187)2.77355749
21Nasal polyposis (HP:0100582)2.74823652
22Abnormality of the anterior horn cell (HP:0006802)2.74498476
23Degeneration of anterior horn cells (HP:0002398)2.74498476
24Aplastic anemia (HP:0001915)2.74108608
25Medulloblastoma (HP:0002885)2.71608023
26Birth length less than 3rd percentile (HP:0003561)2.71447705
27Bile duct proliferation (HP:0001408)2.69501732
28Abnormal biliary tract physiology (HP:0012439)2.69501732
29Azoospermia (HP:0000027)2.69351571
30Hyperventilation (HP:0002883)2.66522964
31Neoplasm of the oral cavity (HP:0100649)2.61530069
32Abnormality of the renal cortex (HP:0011035)2.61165220
33Progressive inability to walk (HP:0002505)2.59228340
34Gait imbalance (HP:0002141)2.57547408
35Type II lissencephaly (HP:0007260)2.54531179
36Congenital primary aphakia (HP:0007707)2.54115922
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.54057209
38Lissencephaly (HP:0001339)2.50684969
39Myelodysplasia (HP:0002863)2.47112834
40Abnormality of the heme biosynthetic pathway (HP:0010472)2.47096510
41Volvulus (HP:0002580)2.46944752
42Impulsivity (HP:0100710)2.45664154
43Abolished electroretinogram (ERG) (HP:0000550)2.44806583
44Rhabdomyosarcoma (HP:0002859)2.41608472
45Nephrogenic diabetes insipidus (HP:0009806)2.39675078
46Hypobetalipoproteinemia (HP:0003563)2.37225669
47Renal cortical cysts (HP:0000803)2.36800573
48Congenital stationary night blindness (HP:0007642)2.35308057
49Abnormality of the nasal mucosa (HP:0000433)2.35076985
50Sloping forehead (HP:0000340)2.34180110
51Pallor (HP:0000980)2.32356904
52Proximal placement of thumb (HP:0009623)2.27849982
53Pancreatic fibrosis (HP:0100732)2.27140403
54Genital tract atresia (HP:0001827)2.26911092
55Ragged-red muscle fibers (HP:0003200)2.26860154
56Bronchitis (HP:0012387)2.26592416
57Attenuation of retinal blood vessels (HP:0007843)2.25996096
58Abnormality of the metopic suture (HP:0005556)2.24836998
59Pendular nystagmus (HP:0012043)2.22784338
60Ependymoma (HP:0002888)2.22358376
61Intestinal atresia (HP:0011100)2.22334343
62Inability to walk (HP:0002540)2.21025155
63Protruding tongue (HP:0010808)2.20892173
64Abnormality of chromosome stability (HP:0003220)2.19926208
65Chromosomal breakage induced by crosslinking agents (HP:0003221)2.19416623
66Vaginal atresia (HP:0000148)2.19408642
67Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.18377100
68Prominent metopic ridge (HP:0005487)2.18341986
69Abnormal gallbladder physiology (HP:0012438)2.17387064
70Cholecystitis (HP:0001082)2.17387064
71Patellar aplasia (HP:0006443)2.17305752
72Nephronophthisis (HP:0000090)2.15461534
73Cerebellar dysplasia (HP:0007033)2.15270391
74Abnormal lung lobation (HP:0002101)2.14367047
75Agnosia (HP:0010524)2.13249243
76Neoplasm of the adrenal cortex (HP:0100641)2.12618416
77Rib fusion (HP:0000902)2.10844439
78Intrahepatic cholestasis (HP:0001406)2.10777307
79Abnormality of midbrain morphology (HP:0002418)2.10452755
80Molar tooth sign on MRI (HP:0002419)2.10452755
81Deviation of the thumb (HP:0009603)2.10368808
82Methylmalonic acidemia (HP:0002912)2.09962228
83Meckel diverticulum (HP:0002245)2.08647541
84Enlarged penis (HP:0000040)2.08507043
85Abnormality of the ileum (HP:0001549)2.07705543
86Tubular atrophy (HP:0000092)2.07527704
87Premature ovarian failure (HP:0008209)2.07381110
88Infertility (HP:0000789)2.07108986
89Abnormal respiratory motile cilium physiology (HP:0012261)2.06814203
90Aplasia/Hypoplasia of the patella (HP:0006498)2.03834421
91Acanthocytosis (HP:0001927)2.02401283
92Chromsome breakage (HP:0040012)2.02342166
93Secondary amenorrhea (HP:0000869)2.00704348
94Rhabdomyolysis (HP:0003201)2.00685326
95Broad-based gait (HP:0002136)2.00270947
96Drooling (HP:0002307)1.99670838
97Optic nerve coloboma (HP:0000588)1.98223488
98Retinal dysplasia (HP:0007973)1.97388550
99Pelvic girdle muscle weakness (HP:0003749)1.97366918
100Prominent nose (HP:0000448)1.96838994
101Absent thumb (HP:0009777)1.96795982
102Poor coordination (HP:0002370)1.96290850
103Cleft eyelid (HP:0000625)1.95906235
104Thrombocytosis (HP:0001894)1.95548054
105Ectopic kidney (HP:0000086)1.95401421
106Abnormality of the columella (HP:0009929)1.94888630
107Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.93273389
108Acute myeloid leukemia (HP:0004808)1.93145620
109Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.91955102
110Decreased activity of mitochondrial respiratory chain (HP:0008972)1.91955102
111Polydipsia (HP:0001959)1.90883018
112Abnormal drinking behavior (HP:0030082)1.90883018
113Abnormality of DNA repair (HP:0003254)1.90236250
114Tongue fasciculations (HP:0001308)1.89577373
115Postaxial foot polydactyly (HP:0001830)1.89085711
116Postaxial hand polydactyly (HP:0001162)1.88701786
117Sclerocornea (HP:0000647)1.86869353
118Hypomagnesemia (HP:0002917)1.86858519
119Abnormality of the phalanges of the hallux (HP:0010057)1.85888414
120Hyperglycinemia (HP:0002154)1.85758494
121Pachygyria (HP:0001302)1.85536430
122Small hand (HP:0200055)1.85135138
123Tubulointerstitial nephritis (HP:0001970)1.84739687
124Macrocytic anemia (HP:0001972)1.84332310
125Increased nuchal translucency (HP:0010880)1.84181724
126IgM deficiency (HP:0002850)1.83779293
127Abnormal pancreas size (HP:0012094)1.83760379
128Truncal obesity (HP:0001956)1.83085473
129Hypoplastic pelvis (HP:0008839)1.83027892
130Anencephaly (HP:0002323)1.82953892
131Bronchiectasis (HP:0002110)1.82266355
132Abnormality of the basal ganglia (HP:0002134)1.82059617
133Heterotopia (HP:0002282)1.81789906
134Narrow forehead (HP:0000341)1.81575106
135Freckling (HP:0001480)1.81496498
136Cystic liver disease (HP:0006706)1.80980826
137Lipid accumulation in hepatocytes (HP:0006561)1.80895409
138Hepatoblastoma (HP:0002884)1.80584640
139Tachypnea (HP:0002789)1.80584597
140Congenital hepatic fibrosis (HP:0002612)1.79718492
141Preaxial hand polydactyly (HP:0001177)1.79570686
142Optic nerve hypoplasia (HP:0000609)1.79199008
143Short 5th finger (HP:0009237)1.79076764
144Pancreatic cysts (HP:0001737)1.79074544
145Bifid tongue (HP:0010297)1.78581535
146Astigmatism (HP:0000483)1.78579315
147Atresia of the external auditory canal (HP:0000413)1.78512324
148Abnormality of the pons (HP:0007361)1.78052345
149Hypothermia (HP:0002045)1.76857810
150Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.76310680
15111 pairs of ribs (HP:0000878)1.76251173
152Oligodactyly (hands) (HP:0001180)1.75965389
153Dandy-Walker malformation (HP:0001305)1.75744639
154Excessive salivation (HP:0003781)1.75141172
155Personality changes (HP:0000751)1.74647927
156Bony spicule pigmentary retinopathy (HP:0007737)1.74014668
157True hermaphroditism (HP:0010459)1.73971250
158Cortical dysplasia (HP:0002539)1.73368336
159Abnormality of the labia minora (HP:0012880)1.72924156
160Type 2 muscle fiber atrophy (HP:0003554)1.71478382
161Oral leukoplakia (HP:0002745)1.71369945
162Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70841849
163Abnormality of the lower motor neuron (HP:0002366)1.70718593
164Clubbing of toes (HP:0100760)1.70341848
165Oculomotor apraxia (HP:0000657)1.69093131
166Aplasia/Hypoplasia of the tibia (HP:0005772)1.68195498
167Widely spaced teeth (HP:0000687)1.68083802
168Abnormality of the alveolar ridges (HP:0006477)1.67842080
169High pitched voice (HP:0001620)1.67591707
170Muscle fibrillation (HP:0010546)1.67525451
171Neoplasm of the small intestine (HP:0100833)1.67320933
172Abnormal number of incisors (HP:0011064)1.67021364
173Limb dystonia (HP:0002451)1.66990520
174Microretrognathia (HP:0000308)1.66954571
175Abnormality of the preputium (HP:0100587)1.66943589
176Aplasia/Hypoplasia of the tongue (HP:0010295)1.66703324
177Aplasia/Hypoplasia of the sternum (HP:0006714)1.66611540
178Prominent nasal bridge (HP:0000426)1.64523008
179Ketoacidosis (HP:0001993)1.64246317
180Specific learning disability (HP:0001328)1.63925852
181Hypoplasia of the pons (HP:0012110)1.62884233
182Methylmalonic aciduria (HP:0012120)1.62111707

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.67036558
2WEE13.87443722
3FRK3.86170624
4NEK23.21761667
5STK33.20108710
6ACVR1B3.00826116
7BUB13.00314485
8MAP3K42.96873193
9PDK42.79470336
10PDK32.79470336
11DYRK32.74009592
12ZAK2.72130736
13TTK2.64344900
14TGFBR12.62236872
15WNK32.55535261
16BRSK22.42681406
17EIF2AK12.41658712
18NME22.26906770
19MAP4K22.12835840
20RPS6KA42.10792032
21FLT32.01422862
22TRIM281.97960195
23CASK1.96591395
24PASK1.96118928
25CDK41.94247910
26BCR1.89962063
27MAP2K71.85622653
28CDK121.82596025
29EEF2K1.71286595
30PLK11.71250888
31SRPK11.66845581
32ATR1.64094485
33NEK11.58075803
34TLK11.57664900
35MAPK131.55952634
36WNK41.48699397
37AKT31.47729460
38ADRBK21.45842636
39PDK21.45321229
40TNIK1.41980391
41STK241.40406498
42PLK41.39285690
43PNCK1.36672159
44LATS11.36547092
45MKNK11.36330814
46ERBB31.35853811
47MARK11.35103900
48CDK61.33479388
49INSRR1.32697339
50AURKB1.30835456
51GRK11.27534894
52VRK11.24175761
53CDK71.21073468
54RPS6KB21.18021377
55CSNK1G11.17075706
56CHEK21.14943026
57CHEK11.14188762
58EPHA31.13634488
59PKN21.13391128
60PLK21.12594146
61PLK31.10072195
62PAK41.09952008
63CSNK1G31.06105325
64TSSK61.02740862
65CSNK1G21.01819678
66BCKDK0.99492022
67STK38L0.98175615
68PINK10.96144804
69MAP3K80.95494357
70ATM0.94121158
71TAOK30.91957311
72FGFR20.90928452
73PIM10.90578084
74SCYL20.90555253
75CSNK1A1L0.89450322
76MAP3K100.89147074
77PAK30.87308794
78STK100.86497280
79DYRK20.84777649
80STK40.82338287
81EIF2AK30.81245337
82CCNB10.79470112
83PRKCG0.78451954
84MKNK20.77628313
85BRSK10.76442711
86BRD40.73712612
87OXSR10.73543087
88AURKA0.72521534
89CDK20.69915758
90PIM20.68075796
91CSNK2A20.66920649
92LRRK20.66220234
93DAPK20.65977679
94MAP2K40.65724100
95MAP2K30.65446101
96CAMKK20.64197526
97TESK10.63339929
98JAK30.62561877
99STK390.61935307
100PRKCE0.61231819
101CDK90.61171591
102ZAP700.60387902
103MAP3K60.59530790
104PTK2B0.55574955
105STK160.55395854
106KIT0.55035716
107KDR0.54538560
108MELK0.54426870
109DYRK1A0.51520965
110TXK0.51271909
111CSNK2A10.50748886
112BRAF0.49848857
113NTRK20.48902316
114NLK0.46935129
115MARK30.45767087
116CDK10.45718159
117CDK30.45689165
118MTOR0.45681729
119PAK10.45041173
120FGFR10.44828862
121SIK20.44206632
122MAPK150.43064020
123CHUK0.43061165
124EIF2AK20.42245515
125MUSK0.42043908
126RAF10.41747479
127EPHA40.41362367
128CSNK1D0.40843315
129PKN10.39976502
130MAPKAPK30.39090985
131NME10.38918573
132IRAK10.38185881
133BMPR1B0.37525884
134CDK80.36789241
135TESK20.36568722
136DYRK1B0.35945480
137CSF1R0.35788029
138SGK20.35682467
139STK110.35447271
140AKT20.34622473
141PRKAA10.34363690
142CSNK1E0.33577700
143PAK20.32664153
144NUAK10.32491883
145RPS6KA50.32335361
146TGFBR20.29376180
147TYK20.29369688
148LATS20.28633527
149PRKDC0.28336725
150MAPKAPK50.26698677
151MATK0.26238703
152TBK10.25389036
153MAPK140.25231116
154RPS6KB10.25101242
155SIK10.24383768
156PRKAA20.21823343
157MAP2K60.21649440
158MAPK10.21282404

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.00746794
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.80754537
3RNA transport_Homo sapiens_hsa030133.40430052
4Mismatch repair_Homo sapiens_hsa034303.39617793
5Proteasome_Homo sapiens_hsa030503.05223635
6Spliceosome_Homo sapiens_hsa030402.95980067
7Ribosome_Homo sapiens_hsa030102.88523651
8RNA polymerase_Homo sapiens_hsa030202.85627263
9Cell cycle_Homo sapiens_hsa041102.84627035
10Selenocompound metabolism_Homo sapiens_hsa004502.64424524
11Homologous recombination_Homo sapiens_hsa034402.48772907
12Butanoate metabolism_Homo sapiens_hsa006502.46104206
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.45345170
14Base excision repair_Homo sapiens_hsa034102.43409442
15Basal transcription factors_Homo sapiens_hsa030222.43175647
16Pyrimidine metabolism_Homo sapiens_hsa002402.42934841
17Nucleotide excision repair_Homo sapiens_hsa034202.42545073
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.21971789
19RNA degradation_Homo sapiens_hsa030182.18578142
20Maturity onset diabetes of the young_Homo sapiens_hsa049502.14209550
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13547400
22One carbon pool by folate_Homo sapiens_hsa006702.13339378
23Non-homologous end-joining_Homo sapiens_hsa034502.12749536
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.09858453
25Phototransduction_Homo sapiens_hsa047442.06519761
26Nicotine addiction_Homo sapiens_hsa050332.00072011
27Fanconi anemia pathway_Homo sapiens_hsa034601.95260089
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80798192
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.72509398
30Steroid biosynthesis_Homo sapiens_hsa001001.71879847
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.70792196
32mRNA surveillance pathway_Homo sapiens_hsa030151.70458446
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.69587792
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64880552
35Biosynthesis of amino acids_Homo sapiens_hsa012301.57442764
36Purine metabolism_Homo sapiens_hsa002301.48946092
37p53 signaling pathway_Homo sapiens_hsa041151.42634985
38Pentose phosphate pathway_Homo sapiens_hsa000301.35940353
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34442311
40Pyruvate metabolism_Homo sapiens_hsa006201.33964588
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33877515
42Regulation of autophagy_Homo sapiens_hsa041401.29284749
43Nitrogen metabolism_Homo sapiens_hsa009101.28820595
44Systemic lupus erythematosus_Homo sapiens_hsa053221.26712855
45Oocyte meiosis_Homo sapiens_hsa041141.25991273
46Linoleic acid metabolism_Homo sapiens_hsa005911.24322344
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24031278
48Ether lipid metabolism_Homo sapiens_hsa005651.19334549
49Carbon metabolism_Homo sapiens_hsa012001.19215518
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18633189
51Taste transduction_Homo sapiens_hsa047421.17877928
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11079569
53Viral carcinogenesis_Homo sapiens_hsa052031.08647152
54Propanoate metabolism_Homo sapiens_hsa006401.08188164
55Epstein-Barr virus infection_Homo sapiens_hsa051691.06341841
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04727005
57Drug metabolism - other enzymes_Homo sapiens_hsa009831.03508788
58Antigen processing and presentation_Homo sapiens_hsa046121.01810039
59Fatty acid elongation_Homo sapiens_hsa000621.00585674
60Herpes simplex infection_Homo sapiens_hsa051680.96886699
61Sulfur relay system_Homo sapiens_hsa041220.96073796
62Oxidative phosphorylation_Homo sapiens_hsa001900.92359113
63Fatty acid metabolism_Homo sapiens_hsa012120.89051051
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84314474
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84224242
66N-Glycan biosynthesis_Homo sapiens_hsa005100.81288372
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80595939
68Tryptophan metabolism_Homo sapiens_hsa003800.79450219
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77934147
70Olfactory transduction_Homo sapiens_hsa047400.75873116
71Folate biosynthesis_Homo sapiens_hsa007900.75810137
72Parkinsons disease_Homo sapiens_hsa050120.72315911
73GABAergic synapse_Homo sapiens_hsa047270.70077581
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68133170
75Glucagon signaling pathway_Homo sapiens_hsa049220.67752247
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66655844
77Vitamin B6 metabolism_Homo sapiens_hsa007500.66076095
78Serotonergic synapse_Homo sapiens_hsa047260.65751201
79Huntingtons disease_Homo sapiens_hsa050160.64841584
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63787954
81Insulin secretion_Homo sapiens_hsa049110.63690611
82HTLV-I infection_Homo sapiens_hsa051660.62299794
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62156197
84Morphine addiction_Homo sapiens_hsa050320.61203590
85Circadian rhythm_Homo sapiens_hsa047100.61199625
86Lysine degradation_Homo sapiens_hsa003100.61138663
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59578066
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59201859
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58513054
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.57981334
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57022243
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56783639
93Dopaminergic synapse_Homo sapiens_hsa047280.55547932
94Small cell lung cancer_Homo sapiens_hsa052220.54886448
95Thyroid cancer_Homo sapiens_hsa052160.54864516
96Glutamatergic synapse_Homo sapiens_hsa047240.53359712
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52038924
98Fructose and mannose metabolism_Homo sapiens_hsa000510.50488219
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49519624
100Amphetamine addiction_Homo sapiens_hsa050310.49473676
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.47779613
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.47721613
103ABC transporters_Homo sapiens_hsa020100.47373736
104Circadian entrainment_Homo sapiens_hsa047130.45015525
105Glutathione metabolism_Homo sapiens_hsa004800.42721227
106Long-term depression_Homo sapiens_hsa047300.42254585
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41165355
108Basal cell carcinoma_Homo sapiens_hsa052170.40856076
109Caffeine metabolism_Homo sapiens_hsa002320.37911640
110Metabolic pathways_Homo sapiens_hsa011000.37665762
111Alcoholism_Homo sapiens_hsa050340.35701064
112Hippo signaling pathway_Homo sapiens_hsa043900.35108034
113Cocaine addiction_Homo sapiens_hsa050300.33008399
114Ovarian steroidogenesis_Homo sapiens_hsa049130.32115137
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30484902
116Legionellosis_Homo sapiens_hsa051340.30343000
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30266665
118Type II diabetes mellitus_Homo sapiens_hsa049300.30138249
119Colorectal cancer_Homo sapiens_hsa052100.28425179
120TGF-beta signaling pathway_Homo sapiens_hsa043500.28268546
121Retinol metabolism_Homo sapiens_hsa008300.28006174
122HIF-1 signaling pathway_Homo sapiens_hsa040660.27331263
123Galactose metabolism_Homo sapiens_hsa000520.26725420
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26275972
125Arginine biosynthesis_Homo sapiens_hsa002200.23419266
126Fatty acid biosynthesis_Homo sapiens_hsa000610.21901707
127Cardiac muscle contraction_Homo sapiens_hsa042600.21802899
128Protein export_Homo sapiens_hsa030600.21700466
129Fatty acid degradation_Homo sapiens_hsa000710.21465314
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.20675120
131Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20634800
132Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19005003
133Chemical carcinogenesis_Homo sapiens_hsa052040.18990004
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17858068
135MicroRNAs in cancer_Homo sapiens_hsa052060.16459226
136Hedgehog signaling pathway_Homo sapiens_hsa043400.15596518
137Hepatitis B_Homo sapiens_hsa051610.15214587
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12889561
139Arginine and proline metabolism_Homo sapiens_hsa003300.11764743
140Pathways in cancer_Homo sapiens_hsa052000.11648423
141Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11322638
142Shigellosis_Homo sapiens_hsa051310.10301119
143PPAR signaling pathway_Homo sapiens_hsa033200.09162618
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.06884246
145Adherens junction_Homo sapiens_hsa045200.06647212
146FoxO signaling pathway_Homo sapiens_hsa040680.06543048
147Peroxisome_Homo sapiens_hsa041460.06032816
148Chronic myeloid leukemia_Homo sapiens_hsa052200.05969355

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