ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	COPI coating of Golgi vesicle (GO:0048205)	4.04019255
2	Golgi transport vesicle coating (GO:0048200)	4.04019255
3	COPII vesicle coating (GO:0048208)	3.95996335
4	fibroblast migration (GO:0010761)	3.73308547
5	protein localization to microtubule (GO:0035372)	3.55077314
6	replication fork processing (GO:0031297)	3.39284829
7	microtubule depolymerization (GO:0007019)	3.38821425
8	regulation of DNA damage checkpoint (GO:2000001)	3.34524955
9	nuclear pore complex assembly (GO:0051292)	3.26497491
10	regulation of mitotic spindle organization (GO:0060236)	3.20811608
11	negative regulation of dendrite development (GO:2000171)	3.20043678
12	establishment of integrated proviral latency (GO:0075713)	3.15122984
13	histone H2A acetylation (GO:0043968)	3.15024871
14	cell wall macromolecule catabolic process (GO:0016998)	3.06230831
15	L-serine transport (GO:0015825)	3.03551461
16	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.01963480
17	nucleotide-sugar biosynthetic process (GO:0009226)	3.00923710
18	desmosome organization (GO:0002934)	2.90858419
19	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.90283021
20	nuclear pore organization (GO:0006999)	2.89594660
21	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.88384574
22	receptor recycling (GO:0001881)	2.87465245
23	DNA ligation (GO:0006266)	2.87249732
24	negative regulation of neurological system process (GO:0031645)	2.83385243
25	nuclear envelope organization (GO:0006998)	2.82074479
26	ribosome assembly (GO:0042255)	2.80733758
27	nuclear envelope disassembly (GO:0051081)	2.79893136
28	membrane disassembly (GO:0030397)	2.79893136
29	ER overload response (GO:0006983)	2.79277389
30	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.76251393
31	mitotic nuclear envelope disassembly (GO:0007077)	2.72976347
32	regulation of glucokinase activity (GO:0033131)	2.70095672
33	regulation of hexokinase activity (GO:1903299)	2.70095672
34	vesicle coating (GO:0006901)	2.69983276
35	acrosome assembly (GO:0001675)	2.67656200
36	establishment of viral latency (GO:0019043)	2.66776876
37	positive regulation of macrophage activation (GO:0043032)	2.64266123
38	prenylation (GO:0097354)	2.61734520
39	protein prenylation (GO:0018342)	2.61734520
40	righting reflex (GO:0060013)	2.61674175
41	nonmotile primary cilium assembly (GO:0035058)	2.57279512
42	regulation of spindle organization (GO:0090224)	2.56171866
43	protein deneddylation (GO:0000338)	2.54336900
44	Leydig cell differentiation (GO:0033327)	2.53966893
45	cullin deneddylation (GO:0010388)	2.53854161
46	negative regulation of dendrite morphogenesis (GO:0050774)	2.52879386
47	cellular protein complex localization (GO:0034629)	2.50664681
48	regulation of retinoic acid receptor signaling pathway (GO:0048385)	2.49930372
49	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.49241536
50	non-recombinational repair (GO:0000726)	2.48450237
51	double-strand break repair via nonhomologous end joining (GO:0006303)	2.48450237
52	spermatid nucleus differentiation (GO:0007289)	2.48103288
53	pore complex assembly (GO:0046931)	2.47892159
54	proteasome assembly (GO:0043248)	2.47868057
55	DNA integration (GO:0015074)	2.47037380
56	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.44930089
57	inositol phosphate-mediated signaling (GO:0048016)	2.44884913
58	serine transport (GO:0032329)	2.44334206
59	macroautophagy (GO:0016236)	2.44006529
60	cell wall macromolecule metabolic process (GO:0044036)	2.42408944
61	protein localization to microtubule cytoskeleton (GO:0072698)	2.42175137
62	viral mRNA export from host cell nucleus (GO:0046784)	2.41637663
63	regulation of sulfur metabolic process (GO:0042762)	2.41295691
64	lipid particle organization (GO:0034389)	2.40331894
65	ER to Golgi vesicle-mediated transport (GO:0006888)	2.37672092
66	norepinephrine metabolic process (GO:0042415)	2.36996459
67	protoporphyrinogen IX biosynthetic process (GO:0006782)	2.36942111
68	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.36845326
69	protein localization to cytoskeleton (GO:0044380)	2.36637397
70	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.36178855
71	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)	2.35148874
72	regulation of cofactor metabolic process (GO:0051193)	2.34919821
73	regulation of coenzyme metabolic process (GO:0051196)	2.34919821
74	regulation of protein glycosylation (GO:0060049)	2.34783123
75	nucleotide transmembrane transport (GO:1901679)	2.34450520
76	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.34233227
77	L-phenylalanine metabolic process (GO:0006558)	2.34233227
78	L-alpha-amino acid transmembrane transport (GO:1902475)	2.34208275
79	pteridine-containing compound biosynthetic process (GO:0042559)	2.33276096
80	mitotic sister chromatid cohesion (GO:0007064)	2.33113053
81	cofactor catabolic process (GO:0051187)	2.32068540
82	binding of sperm to zona pellucida (GO:0007339)	2.31780374
83	response to pheromone (GO:0019236)	2.31487954
84	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.31472965
85	nitric oxide biosynthetic process (GO:0006809)	2.30015691
86	regulation of cellular amino acid metabolic process (GO:0006521)	2.29969019
87	regulation of mitochondrial translation (GO:0070129)	2.28694748
88	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.27164153
89	mitotic spindle organization (GO:0007052)	2.26975738
90	estrogen biosynthetic process (GO:0006703)	2.26445376
91	branched-chain amino acid catabolic process (GO:0009083)	2.25743607
92	tRNA aminoacylation for protein translation (GO:0006418)	2.22165270
93	protein targeting to Golgi (GO:0000042)	2.20820734
94	zinc ion transport (GO:0006829)	2.19545802
95	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.18774984
96	acrosome reaction (GO:0007340)	2.18669184
97	coenzyme catabolic process (GO:0009109)	2.17473906
98	nucleus organization (GO:0006997)	2.16916908
99	porphyrin-containing compound biosynthetic process (GO:0006779)	2.15838086
100	mitotic metaphase plate congression (GO:0007080)	2.15406679

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.14856271
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.77261251
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.74586595
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.67497190
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.65253110
6	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.98184875
7	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.77071679
8	* PRDM5_23873026_ChIP-Seq_MEFs_Mouse	2.75451809
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.54098454
10	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.51306114
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.41542840
12	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.36547416
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.35535105
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.29232945
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.22603537
16	PADI4_21655091_ChIP-ChIP_MCF-7_Human	2.08964572
17	DCP1A_22483619_ChIP-Seq_HELA_Human	2.03387465
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.03007874
19	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.97504674
20	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.92467683
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.88832470
22	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.83436681
23	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.80242205
24	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.76655864
25	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.74700551
26	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.70831912
27	GATA1_22025678_ChIP-Seq_K562_Human	1.70359271
28	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.59620703
29	GABP_19822575_ChIP-Seq_HepG2_Human	1.52960706
30	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.52947089
31	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.52519154
32	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.52388110
33	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.47044210
34	TFEB_21752829_ChIP-Seq_HELA_Human	1.47017103
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.39585494
36	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.39178658
37	KDM5A_27292631_Chip-Seq_BREAST_Human	1.37518599
38	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.37132837
39	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.36144088
40	HTT_18923047_ChIP-ChIP_STHdh_Human	1.35406843
41	ZNF274_21170338_ChIP-Seq_K562_Hela	1.34743030
42	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.34648131
43	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.33394253
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.27343256
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27343256
46	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.27075573
47	AR_21909140_ChIP-Seq_LNCAP_Human	1.26288243
48	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.24334575
49	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.23531392
50	ZNF263_19887448_ChIP-Seq_K562_Human	1.22605280
51	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.22602233
52	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.22359400
53	CIITA_25753668_ChIP-Seq_RAJI_Human	1.22086867
54	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.19947033
55	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.19935502
56	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.19840373
57	E2F7_22180533_ChIP-Seq_HELA_Human	1.19486194
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.17256943
59	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.16478291
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.14859344
61	FOXP3_21729870_ChIP-Seq_TREG_Human	1.14625475
62	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.14322567
63	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.12938285
64	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.12496300
65	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.10360485
66	FUS_26573619_Chip-Seq_HEK293_Human	1.07866786
67	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.05466023
68	GBX2_23144817_ChIP-Seq_PC3_Human	1.05109674
69	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.04943933
70	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.04587846
71	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.04557000
72	EWS_26573619_Chip-Seq_HEK293_Human	1.02376398
73	GATA4_21415370_ChIP-Seq_HL-1_Mouse	1.01958143
74	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.01849902
75	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01380010
76	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.00485212
77	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.00395313
78	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.99710239
79	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.99201939
80	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.99020097
81	ATF3_27146783_Chip-Seq_COLON_Human	0.98692564
82	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.98357756
83	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	0.97196216
84	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	0.97196216
85	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.95058248
86	PHF8_20622853_ChIP-Seq_HELA_Human	0.94199009
87	BRD4_25478319_ChIP-Seq_HGPS_Human	0.93157795
88	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.92377087
89	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.92003383
90	TTF2_22483619_ChIP-Seq_HELA_Human	0.91993178
91	P300_19829295_ChIP-Seq_ESCs_Human	0.90652580
92	NFYB_21822215_ChIP-Seq_K562_Human	0.90450340
93	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.89472630
94	XRN2_22483619_ChIP-Seq_HELA_Human	0.89108104
95	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.88841687
96	EGR1_19374776_ChIP-ChIP_THP-1_Human	0.88586743
97	SMAD4_21799915_ChIP-Seq_A2780_Human	0.87901539
98	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.86192406
99	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.85609643
100	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.85322645

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	3.27621885
2	MP0002089_abnormal_postnatal_growth/wei	3.17973950
3	MP0003195_calcinosis	2.85472071
4	MP0005670_abnormal_white_adipose	2.82610352
5	MP0008058_abnormal_DNA_repair	2.54472751
6	MP0003950_abnormal_plasma_membrane	2.51114483
7	MP0004233_abnormal_muscle_weight	2.17358309
8	MP0005645_abnormal_hypothalamus_physiol	1.96959690
9	MP0003111_abnormal_nucleus_morphology	1.86573257
10	MP0003656_abnormal_erythrocyte_physiolo	1.82056074
11	MP0009697_abnormal_copulation	1.79844405
12	MP0003718_maternal_effect	1.75354314
13	MP0003122_maternal_imprinting	1.75282914
14	MP0009780_abnormal_chondrocyte_physiolo	1.74914514
15	MP0002102_abnormal_ear_morphology	1.70269656
16	MP0000003_abnormal_adipose_tissue	1.68904303
17	MP0004147_increased_porphyrin_level	1.67354486
18	MP0010234_abnormal_vibrissa_follicle	1.67136146
19	MP0009046_muscle_twitch	1.66806776
20	MP0000013_abnormal_adipose_tissue	1.63812450
21	MP0003186_abnormal_redox_activity	1.62784490
22	MP0005646_abnormal_pituitary_gland	1.62317332
23	MP0003868_abnormal_feces_composition	1.59095124
24	MP0001529_abnormal_vocalization	1.57776912
25	MP0002822_catalepsy	1.55429808
26	MP0010094_abnormal_chromosome_stability	1.50507714
27	MP0004270_analgesia	1.47862140
28	MP0003077_abnormal_cell_cycle	1.46755001
29	MP0008057_abnormal_DNA_replication	1.46402229
30	MP0003890_abnormal_embryonic-extraembry	1.46152168
31	MP0003806_abnormal_nucleotide_metabolis	1.43521653
32	MP0005410_abnormal_fertilization	1.39408499
33	MP0001666_abnormal_nutrient_absorption	1.38985373
34	MP0005395_other_phenotype	1.38771061
35	MP0000751_myopathy	1.37545094
36	MP0001727_abnormal_embryo_implantation	1.30867371
37	MP0003941_abnormal_skin_development	1.30523403
38	MP0004957_abnormal_blastocyst_morpholog	1.29923627
39	MP0002234_abnormal_pharynx_morphology	1.29349530
40	MP0010352_gastrointestinal_tract_polyps	1.24120815
41	MP0004272_abnormal_basement_membrane	1.22078305
42	MP0001764_abnormal_homeostasis	1.18528141
43	MP0002090_abnormal_vision	1.18182311
44	MP0002168_other_aberrant_phenotype	1.15807532
45	MP0008007_abnormal_cellular_replicative	1.13909636
46	MP0004782_abnormal_surfactant_physiolog	1.11580723
47	MP0005253_abnormal_eye_physiology	1.11461742
48	MP0008932_abnormal_embryonic_tissue	1.09782841
49	MP0003123_paternal_imprinting	1.04591788
50	MP0008877_abnormal_DNA_methylation	1.02993468
51	MP0001984_abnormal_olfaction	1.00409564
52	MP0005623_abnormal_meninges_morphology	0.99213134
53	MP0000613_abnormal_salivary_gland	0.97868113
54	MP0002060_abnormal_skin_morphology	0.97229561
55	MP0001697_abnormal_embryo_size	0.96435925
56	MP0001730_embryonic_growth_arrest	0.96358091
57	MP0000750_abnormal_muscle_regeneration	0.95692316
58	MP0002909_abnormal_adrenal_gland	0.93522063
59	MP0005332_abnormal_amino_acid	0.92841503
60	MP0001929_abnormal_gametogenesis	0.92562175
61	MP0005379_endocrine/exocrine_gland_phen	0.91761074
62	MP0005501_abnormal_skin_physiology	0.91221571
63	MP0004215_abnormal_myocardial_fiber	0.90874797
64	MP0010386_abnormal_urinary_bladder	0.90153562
65	MP0001191_abnormal_skin_condition	0.88172713
66	MP0003786_premature_aging	0.85979531
67	MP0000427_abnormal_hair_cycle	0.84977415
68	MP0005375_adipose_tissue_phenotype	0.83315957
69	MP0003698_abnormal_male_reproductive	0.82349939
70	MP0003121_genomic_imprinting	0.81342029
71	MP0002269_muscular_atrophy	0.80481119
72	MP0006072_abnormal_retinal_apoptosis	0.80286463
73	MP0000350_abnormal_cell_proliferation	0.79390956
74	MP0003183_abnormal_peptide_metabolism	0.77826840
75	MP0001661_extended_life_span	0.76624781
76	MP0010771_integument_phenotype	0.76356968
77	MP0001216_abnormal_epidermal_layer	0.76195567
78	MP0004484_altered_response_of	0.75988435
79	MP0005551_abnormal_eye_electrophysiolog	0.75699231
80	MP0000462_abnormal_digestive_system	0.75079323
81	MP0001502_abnormal_circadian_rhythm	0.74790158
82	MP0004264_abnormal_extraembryonic_tissu	0.74551736
83	MP0005448_abnormal_energy_balance	0.74407839
84	MP0002080_prenatal_lethality	0.73831678
85	MP0002295_abnormal_pulmonary_circulatio	0.72679989
86	MP0005452_abnormal_adipose_tissue	0.72403761
87	MP0003011_delayed_dark_adaptation	0.72219592
88	MP0003787_abnormal_imprinting	0.72069811
89	MP0005330_cardiomyopathy	0.70507357
90	MP0004924_abnormal_behavior	0.69636480
91	MP0005386_behavior/neurological_phenoty	0.69636480
92	MP0003045_fibrosis	0.68489671
93	MP0000358_abnormal_cell_content/	0.68338000
94	MP0005380_embryogenesis_phenotype	0.67704633
95	MP0001672_abnormal_embryogenesis/_devel	0.67704633
96	MP0001944_abnormal_pancreas_morphology	0.67555510
97	MP0000762_abnormal_tongue_morphology	0.67493774
98	MP0001299_abnormal_eye_distance/	0.66151819
99	MP0004134_abnormal_chest_morphology	0.65585572
100	MP0002796_impaired_skin_barrier	0.65115620

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoglycemic seizures (HP:0002173)	3.86704648
2	Hypoglycemic coma (HP:0001325)	3.65052872
3	Shoulder girdle muscle weakness (HP:0003547)	3.35210644
4	Volvulus (HP:0002580)	3.28937281
5	Tetraparesis (HP:0002273)	2.96453963
6	Pelvic girdle muscle weakness (HP:0003749)	2.87454588
7	Symptomatic seizures (HP:0011145)	2.85545649
8	Papillary thyroid carcinoma (HP:0002895)	2.83645468
9	Methylmalonic acidemia (HP:0002912)	2.82406032
10	Reduced antithrombin III activity (HP:0001976)	2.72328109
11	Hyperinsulinemic hypoglycemia (HP:0000825)	2.71311891
12	Abnormality of the musculature of the pelvis (HP:0001469)	2.69130558
13	Abnormality of the hip-girdle musculature (HP:0001445)	2.69130558
14	Limb hypertonia (HP:0002509)	2.63356426
15	Muscular hypotonia of the trunk (HP:0008936)	2.63356053
16	Muscular dystrophy (HP:0003560)	2.54829086
17	Intestinal atresia (HP:0011100)	2.50340423
18	Tubulointerstitial nephritis (HP:0001970)	2.47306887
19	Thyroid carcinoma (HP:0002890)	2.45640066
20	Abnormality of the parathyroid morphology (HP:0011766)	2.40318026
21	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.35298970
22	Hyperglycinemia (HP:0002154)	2.32525543
23	Abnormal gallbladder morphology (HP:0012437)	2.31930313
24	Congenital primary aphakia (HP:0007707)	2.30066425
25	Onycholysis (HP:0001806)	2.25454810
26	Intrahepatic cholestasis (HP:0001406)	2.22468593
27	EEG with generalized epileptiform discharges (HP:0011198)	2.22310660
28	Abnormality of dental color (HP:0011073)	2.21322383
29	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.17710246
30	Gait imbalance (HP:0002141)	2.16986578
31	Medial flaring of the eyebrow (HP:0010747)	2.16393158
32	Curly hair (HP:0002212)	2.14491621
33	Abnormal gallbladder physiology (HP:0012438)	2.14171345
34	Cholecystitis (HP:0001082)	2.14171345
35	Hypsarrhythmia (HP:0002521)	2.13105116
36	Upper limb muscle weakness (HP:0003484)	2.12284946
37	Autoamputation (HP:0001218)	2.10875378
38	Exercise-induced myalgia (HP:0003738)	2.10840647
39	Nephrogenic diabetes insipidus (HP:0009806)	2.10818849
40	Proximal amyotrophy (HP:0007126)	2.08716540
41	Abnormality of polysaccharide metabolism (HP:0011012)	2.07220714
42	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.07220714
43	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.07220714
44	Posterior subcapsular cataract (HP:0007787)	2.04755995
45	Hypobetalipoproteinemia (HP:0003563)	2.03542377
46	Congenital malformation of the right heart (HP:0011723)	2.02996464
47	Double outlet right ventricle (HP:0001719)	2.02996464
48	Epileptiform EEG discharges (HP:0011182)	2.02592230
49	Urinary glycosaminoglycan excretion (HP:0003541)	2.01346256
50	Mucopolysacchariduria (HP:0008155)	2.01346256
51	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.99305248
52	Abnormality of the gallbladder (HP:0005264)	1.97392456
53	Dyskinesia (HP:0100660)	1.97121661
54	Decreased testicular size (HP:0008734)	1.96436101
55	Hepatic necrosis (HP:0002605)	1.93140133
56	Abnormal auditory evoked potentials (HP:0006958)	1.92871921
57	Cholelithiasis (HP:0001081)	1.92443604
58	Type I transferrin isoform profile (HP:0003642)	1.91639417
59	Limb-girdle muscle atrophy (HP:0003797)	1.85979476
60	Amblyopia (HP:0000646)	1.85003526
61	Entropion (HP:0000621)	1.84361659
62	Fat malabsorption (HP:0002630)	1.82725726
63	Genetic anticipation (HP:0003743)	1.82128021
64	Pheochromocytoma (HP:0002666)	1.80995426
65	Dry hair (HP:0011359)	1.80304836
66	Absent eyebrow (HP:0002223)	1.79636009
67	Ketoacidosis (HP:0001993)	1.78278472
68	Hemiparesis (HP:0001269)	1.77937413
69	Microvesicular hepatic steatosis (HP:0001414)	1.75487893
70	Abnormality of nail color (HP:0100643)	1.72373876
71	Large for gestational age (HP:0001520)	1.71916170
72	Vacuolated lymphocytes (HP:0001922)	1.71637082
73	Decreased lacrimation (HP:0000633)	1.70928284
74	Abnormality of the intrinsic pathway (HP:0010989)	1.70320404
75	Ectropion (HP:0000656)	1.70294057
76	Follicular hyperkeratosis (HP:0007502)	1.70240696
77	Aqueductal stenosis (HP:0002410)	1.69433314
78	Abnormality of vitamin B metabolism (HP:0004340)	1.66772002
79	Drooling (HP:0002307)	1.66694957
80	Albinism (HP:0001022)	1.65431277
81	Rimmed vacuoles (HP:0003805)	1.62932370
82	Steatorrhea (HP:0002570)	1.61704862
83	Dental crowding (HP:0000678)	1.61471429
84	Methylmalonic aciduria (HP:0012120)	1.60561871
85	Hypoplastic pelvis (HP:0008839)	1.60418669
86	Subcapsular cataract (HP:0000523)	1.60002298
87	Open mouth (HP:0000194)	1.59790625
88	Renal cortical cysts (HP:0000803)	1.59479554
89	Exercise-induced muscle cramps (HP:0003710)	1.59410506
90	Hypokinesia (HP:0002375)	1.59244308
91	Menstrual irregularities (HP:0000858)	1.57980749
92	Heterotopia (HP:0002282)	1.57910568
93	Partial agenesis of the corpus callosum (HP:0001338)	1.56659834
94	Bony spicule pigmentary retinopathy (HP:0007737)	1.56462012
95	Cone-rod dystrophy (HP:0000548)	1.56242154
96	Poikiloderma (HP:0001029)	1.55581446
97	Unilateral renal agenesis (HP:0000122)	1.54955507
98	Hepatocellular necrosis (HP:0001404)	1.54122573
99	Hyperglycemia (HP:0003074)	1.54037591
100	Abnormality of the lower motor neuron (HP:0002366)	1.53855113

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	4.68157953
2	MAP3K12	3.53393595
3	PBK	3.00151176
4	AKT3	2.99299080
5	BCR	2.86518074
6	SIK3	2.77776312
7	IRAK2	2.46022914
8	PDK2	2.25362399
9	BRD4	2.21639411
10	EPHA2	2.13069598
11	BUB1	2.12618831
12	NEK1	2.05695439
13	TESK1	2.04256527
14	SRPK1	1.99959201
15	IRAK1	1.92428331
16	MST1R	1.92192912
17	LATS1	1.88599183
18	FRK	1.82432205
19	BRSK2	1.69608865
20	MAP3K3	1.51433171
21	BCKDK	1.48651403
22	WNK3	1.40238620
23	EIF2AK3	1.30178938
24	WEE1	1.27716655
25	MST4	1.25818030
26	EIF2AK1	1.24840147
27	MAP3K2	1.23190079
28	MET	1.22976653
29	SCYL2	1.17654160
30	ERBB3	1.16857603
31	PLK4	1.16804020
32	BRAF	1.15661081
33	CASK	1.14789833
34	PLK3	1.11429616
35	TSSK6	1.07607658
36	INSRR	1.02705123
37	PTK2	1.02542810
38	STK16	0.99886941
39	TTK	0.97893873
40	LIMK1	0.97792610
41	AURKA	0.97362941
42	NTRK3	0.96252799
43	NTRK1	0.96251739
44	STK3	0.96088241
45	STK38	0.93890624
46	BRSK1	0.92892897
47	CSNK1G3	0.92734182
48	ERBB4	0.92308389
49	DDR2	0.91814324
50	CSNK1G1	0.87213961
51	DYRK1B	0.81235713
52	PHKG2	0.79816728
53	PHKG1	0.79816728
54	MAP3K5	0.75077617
55	PLK1	0.73822062
56	CAMK2G	0.73062682
57	NME1	0.72271812
58	VRK1	0.71985596
59	PIM2	0.71176807
60	MAP3K4	0.68016039
61	KSR1	0.67225171
62	MINK1	0.66445273
63	TRPM7	0.65675546
64	MAP4K2	0.65277885
65	CHEK1	0.64479971
66	MAP3K10	0.62996119
67	CDC7	0.60613947
68	CSNK1G2	0.60579021
69	DYRK1A	0.57927776
70	AURKB	0.56785303
71	PINK1	0.55447403
72	SGK3	0.55178305
73	PAK3	0.54843730
74	MAP2K7	0.53228142
75	CSNK1A1L	0.52951832
76	ATM	0.52945216
77	SGK2	0.52471980
78	NUAK1	0.51550750
79	PRKCE	0.50341368
80	YES1	0.48110480
81	LATS2	0.47677411
82	NEK6	0.47219141
83	CDK1	0.47078507
84	UHMK1	0.46989894
85	PRKAA1	0.46000529
86	CSNK1A1	0.43317401
87	VRK2	0.43189330
88	ATR	0.42179874
89	CSNK1E	0.41286306
90	MAP2K1	0.41166473
91	MARK1	0.40669560
92	ABL2	0.39269411
93	EPHA4	0.38617808
94	CAMK2D	0.38117508
95	PNCK	0.33381741
96	EIF2AK2	0.32077779
97	CSNK2A2	0.31474183
98	CDK2	0.31098767
99	MAP3K9	0.26913592
100	PLK2	0.26646007

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	2.78380331
2	Proteasome_Homo sapiens_hsa03050	2.72565503
3	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.37021846
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.31819504
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.26888956
6	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.26837856
7	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.12228947
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.08290243
9	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.06742313
10	Steroid biosynthesis_Homo sapiens_hsa00100	2.05982083
11	Circadian rhythm_Homo sapiens_hsa04710	1.97822958
12	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.88526362
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.86803584
14	Fatty acid elongation_Homo sapiens_hsa00062	1.83422999
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.82769571
16	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.76426471
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.73021657
18	Propanoate metabolism_Homo sapiens_hsa00640	1.66854543
19	Sulfur metabolism_Homo sapiens_hsa00920	1.66285838
20	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.66023496
21	RNA transport_Homo sapiens_hsa03013	1.65832868
22	Folate biosynthesis_Homo sapiens_hsa00790	1.64357236
23	Non-homologous end-joining_Homo sapiens_hsa03450	1.63258131
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.61268630
25	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.54196834
26	Butanoate metabolism_Homo sapiens_hsa00650	1.53343965
27	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.45480401
28	Spliceosome_Homo sapiens_hsa03040	1.42837923
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.42420676
30	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.38238256
31	Arginine biosynthesis_Homo sapiens_hsa00220	1.30861395
32	Carbon metabolism_Homo sapiens_hsa01200	1.27235053
33	Sphingolipid metabolism_Homo sapiens_hsa00600	1.26874302
34	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.24875666
35	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.21727504
36	Vibrio cholerae infection_Homo sapiens_hsa05110	1.21197866
37	Peroxisome_Homo sapiens_hsa04146	1.20097068
38	Oocyte meiosis_Homo sapiens_hsa04114	1.18064748
39	Base excision repair_Homo sapiens_hsa03410	1.12314864
40	Fatty acid metabolism_Homo sapiens_hsa01212	1.08777285
41	RNA polymerase_Homo sapiens_hsa03020	1.03157548
42	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.01977644
43	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.00409188
44	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.00250631
45	Pentose phosphate pathway_Homo sapiens_hsa00030	0.98638634
46	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.98409466
47	Insulin secretion_Homo sapiens_hsa04911	0.95861597
48	Regulation of autophagy_Homo sapiens_hsa04140	0.95481972
49	Pyruvate metabolism_Homo sapiens_hsa00620	0.94938305
50	One carbon pool by folate_Homo sapiens_hsa00670	0.90604340
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.87290691
52	Arginine and proline metabolism_Homo sapiens_hsa00330	0.81899022
53	mRNA surveillance pathway_Homo sapiens_hsa03015	0.79429267
54	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.78500306
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.77567904
56	Nucleotide excision repair_Homo sapiens_hsa03420	0.77454269
57	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.77261601
58	Pyrimidine metabolism_Homo sapiens_hsa00240	0.73911726
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72100815
60	Glutathione metabolism_Homo sapiens_hsa00480	0.71582034
61	Cell cycle_Homo sapiens_hsa04110	0.70765057
62	Phenylalanine metabolism_Homo sapiens_hsa00360	0.69558135
63	Basal transcription factors_Homo sapiens_hsa03022	0.68635643
64	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.68515993
65	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.67096818
66	Metabolic pathways_Homo sapiens_hsa01100	0.66191222
67	Cocaine addiction_Homo sapiens_hsa05030	0.65131178
68	Thyroid cancer_Homo sapiens_hsa05216	0.62486298
69	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.59719176
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.56075960
71	Long-term depression_Homo sapiens_hsa04730	0.55356101
72	Glucagon signaling pathway_Homo sapiens_hsa04922	0.54696738
73	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.53885100
74	Hippo signaling pathway_Homo sapiens_hsa04390	0.50646967
75	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.49572035
76	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.48966764
77	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.46645929
78	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.45829530
79	Purine metabolism_Homo sapiens_hsa00230	0.45516573
80	Lysine degradation_Homo sapiens_hsa00310	0.45479357
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45206927
82	RNA degradation_Homo sapiens_hsa03018	0.44873044
83	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.43814860
84	Pancreatic secretion_Homo sapiens_hsa04972	0.43356143
85	AMPK signaling pathway_Homo sapiens_hsa04152	0.43056040
86	p53 signaling pathway_Homo sapiens_hsa04115	0.40604016
87	Tight junction_Homo sapiens_hsa04530	0.39277527
88	Caffeine metabolism_Homo sapiens_hsa00232	0.39129898
89	Fatty acid degradation_Homo sapiens_hsa00071	0.38985975
90	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.36438621
91	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.36255167
92	Amphetamine addiction_Homo sapiens_hsa05031	0.36230082
93	Taste transduction_Homo sapiens_hsa04742	0.36210495
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.35472844
95	Gap junction_Homo sapiens_hsa04540	0.34217039
96	Dopaminergic synapse_Homo sapiens_hsa04728	0.29789173
97	Adherens junction_Homo sapiens_hsa04520	0.28629188
98	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.28315063
99	Tyrosine metabolism_Homo sapiens_hsa00350	0.28259811
100	mTOR signaling pathway_Homo sapiens_hsa04150	0.25893765

ZSCAN12P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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