ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	4.85362973
2	chaperone-mediated protein transport (GO:0072321)	4.58522982
3	neural tube formation (GO:0001841)	4.51260605
4	DNA double-strand break processing (GO:0000729)	4.23974569
5	nucleobase catabolic process (GO:0046113)	4.03783864
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.88897880
7	protein deneddylation (GO:0000338)	3.85194802
8	cullin deneddylation (GO:0010388)	3.76330500
9	DNA damage response, detection of DNA damage (GO:0042769)	3.74356717
10	sequestering of actin monomers (GO:0042989)	3.68303684
11	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.67701796
12	behavioral response to nicotine (GO:0035095)	3.66661723
13	protein complex biogenesis (GO:0070271)	3.66622435
14	mitochondrial respiratory chain complex assembly (GO:0033108)	3.64543221
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.59764548
16	ATP synthesis coupled proton transport (GO:0015986)	3.59764548
17	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.50941685
18	ubiquinone biosynthetic process (GO:0006744)	3.47556654
19	ubiquinone metabolic process (GO:0006743)	3.43138141
20	DNA integration (GO:0015074)	3.32752080
21	respiratory chain complex IV assembly (GO:0008535)	3.32207971
22	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.31526937
23	protein neddylation (GO:0045116)	3.31409187
24	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.29441230
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.29441230
26	NADH dehydrogenase complex assembly (GO:0010257)	3.29441230
27	DNA deamination (GO:0045006)	3.27186772
28	protein localization to cilium (GO:0061512)	3.25673005
29	limb bud formation (GO:0060174)	3.23133760
30	regulation of cilium movement (GO:0003352)	3.22363676
31	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.20998460
32	negative regulation of telomere maintenance (GO:0032205)	3.19298722
33	protein K6-linked ubiquitination (GO:0085020)	3.16970422
34	histone H2A acetylation (GO:0043968)	3.13911093
35	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.13346031
36	intraciliary transport (GO:0042073)	3.10120491
37	organelle disassembly (GO:1903008)	3.09100290
38	preassembly of GPI anchor in ER membrane (GO:0016254)	3.06419824
39	platelet dense granule organization (GO:0060155)	3.05411812
40	protein-cofactor linkage (GO:0018065)	3.04220237
41	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.01634672
42	regulation of mitochondrial translation (GO:0070129)	3.01493567
43	regulation of helicase activity (GO:0051095)	3.00588356
44	epithelial cilium movement (GO:0003351)	2.99632387
45	presynaptic membrane organization (GO:0097090)	2.98441474
46	water-soluble vitamin biosynthetic process (GO:0042364)	2.97509790
47	olfactory bulb development (GO:0021772)	2.92567402
48	ribonucleoprotein complex disassembly (GO:0032988)	2.91404534
49	cytochrome complex assembly (GO:0017004)	2.91280981
50	nonmotile primary cilium assembly (GO:0035058)	2.88765599
51	anterograde synaptic vesicle transport (GO:0048490)	2.82429657
52	presynaptic membrane assembly (GO:0097105)	2.80993072
53	quinone biosynthetic process (GO:1901663)	2.80829997
54	iron-sulfur cluster assembly (GO:0016226)	2.80792984
55	metallo-sulfur cluster assembly (GO:0031163)	2.80792984
56	regulation of mitotic spindle checkpoint (GO:1903504)	2.79751034
57	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.79751034
58	DNA catabolic process, exonucleolytic (GO:0000738)	2.78992787
59	mannosylation (GO:0097502)	2.76713943
60	electron transport chain (GO:0022900)	2.76375634
61	DNA demethylation (GO:0080111)	2.76284319
62	respiratory electron transport chain (GO:0022904)	2.75037709
63	replication fork processing (GO:0031297)	2.74095233
64	tRNA processing (GO:0008033)	2.71456330
65	inositol phosphate catabolic process (GO:0071545)	2.70995024
66	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.68989891
67	sympathetic nervous system development (GO:0048485)	2.67991928
68	regulation of telomere maintenance (GO:0032204)	2.64827661
69	GPI anchor metabolic process (GO:0006505)	2.64658400
70	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.63538458
71	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.63538458
72	forebrain neuron differentiation (GO:0021879)	2.61368461
73	resolution of meiotic recombination intermediates (GO:0000712)	2.61335333
74	rRNA catabolic process (GO:0016075)	2.60186124
75	chromatin remodeling at centromere (GO:0031055)	2.60112286
76	regulation of cellular amino acid metabolic process (GO:0006521)	2.59826158
77	positive regulation of mRNA processing (GO:0050685)	2.58624310
78	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.58168260
79	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.57981164
80	regulation of action potential (GO:0098900)	2.57700558
81	termination of RNA polymerase III transcription (GO:0006386)	2.57549751
82	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.57549751
83	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.56785896
84	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.55718001
85	microtubule depolymerization (GO:0007019)	2.55638933
86	regulation of glucokinase activity (GO:0033131)	2.55474714
87	regulation of hexokinase activity (GO:1903299)	2.55474714
88	GMP metabolic process (GO:0046037)	2.54935442
89	nucleotide transmembrane transport (GO:1901679)	2.54009454
90	neuron cell-cell adhesion (GO:0007158)	2.53934638
91	cilium morphogenesis (GO:0060271)	2.53275912
92	ncRNA catabolic process (GO:0034661)	2.52095983
93	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.51755123
94	inositol phosphate dephosphorylation (GO:0046855)	2.51755123
95	negative regulation of DNA recombination (GO:0045910)	2.51453436
96	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.51440592
97	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.51440592
98	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.47609826
99	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.47609826
100	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.47609826

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.12201318
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.06582004
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.76843722
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.41619838
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.38841620
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.38688635
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.33253288
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.98784839
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.57145986
10	ELK1_19687146_ChIP-ChIP_HELA_Human	2.56024140
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.53738327
12	* VDR_23849224_ChIP-Seq_CD4+_Human	2.41020575
13	IRF1_19129219_ChIP-ChIP_H3396_Human	2.30834186
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.30309462
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.28791671
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.25102831
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.21838625
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.21574217
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.17403566
20	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.09789096
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.07202109
22	FOXP3_21729870_ChIP-Seq_TREG_Human	2.06705745
23	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.02066454
24	FUS_26573619_Chip-Seq_HEK293_Human	1.95893363
25	EWS_26573619_Chip-Seq_HEK293_Human	1.91143700
26	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.89474235
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.86112172
28	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.82124637
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.80592015
30	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.73092919
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.71709695
32	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.71175849
33	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.68574851
34	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.67906757
35	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.67889358
36	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.66889157
37	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.66884982
38	TAF15_26573619_Chip-Seq_HEK293_Human	1.65070626
39	VDR_22108803_ChIP-Seq_LS180_Human	1.64514650
40	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.64508203
41	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.62739034
42	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.61631884
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.60118520
44	GABP_19822575_ChIP-Seq_HepG2_Human	1.52388855
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.46924976
46	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.45451693
47	P300_19829295_ChIP-Seq_ESCs_Human	1.44735927
48	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.44320889
49	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.42593455
50	GBX2_23144817_ChIP-Seq_PC3_Human	1.41726688
51	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.41711348
52	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.39828008
53	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.39562977
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.38994350
55	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.38668495
56	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.35028517
57	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.29108571
58	TTF2_22483619_ChIP-Seq_HELA_Human	1.29000363
59	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28129720
60	EZH2_22144423_ChIP-Seq_EOC_Human	1.26134644
61	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.22733236
62	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.19617422
63	DCP1A_22483619_ChIP-Seq_HELA_Human	1.19244479
64	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.18449601
65	CIITA_25753668_ChIP-Seq_RAJI_Human	1.15430060
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13809862
67	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.09631352
68	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.06636412
69	ER_23166858_ChIP-Seq_MCF-7_Human	1.06306778
70	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.03717077
71	CBP_20019798_ChIP-Seq_JUKART_Human	1.02277848
72	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02277848
73	XRN2_22483619_ChIP-Seq_HELA_Human	1.02105886
74	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.01451654
75	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.00762265
76	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.99568238
77	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.99364760
78	RNF2_27304074_Chip-Seq_NSC_Mouse	0.98838584
79	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.97141780
80	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.94538750
81	SOX2_19829295_ChIP-Seq_ESCs_Human	0.94449916
82	NANOG_19829295_ChIP-Seq_ESCs_Human	0.94449916
83	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.94037247
84	* ELK1_22589737_ChIP-Seq_MCF10A_Human	0.93413834
85	REST_21632747_ChIP-Seq_MESCs_Mouse	0.92605333
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.92338989
87	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.90910900
88	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.90587104
89	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.90247162
90	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.90223186
91	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.89826254
92	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.89655986
93	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.89080167
94	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.89001395
95	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.88046979
96	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.88032427
97	HTT_18923047_ChIP-ChIP_STHdh_Human	0.87709715
98	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.87472908
99	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.86438499
100	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.86085371

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.80832175
2	MP0008877_abnormal_DNA_methylation	3.63303977
3	MP0003880_abnormal_central_pattern	3.37908551
4	MP0002102_abnormal_ear_morphology	2.98149223
5	MP0008789_abnormal_olfactory_epithelium	2.81105417
6	MP0006292_abnormal_olfactory_placode	2.70811954
7	MP0008058_abnormal_DNA_repair	2.60497794
8	MP0003121_genomic_imprinting	2.54171461
9	MP0005394_taste/olfaction_phenotype	2.44939609
10	MP0005499_abnormal_olfactory_system	2.44939609
11	MP0001188_hyperpigmentation	2.43579015
12	MP0001529_abnormal_vocalization	2.31759569
13	MP0006072_abnormal_retinal_apoptosis	2.29616327
14	MP0003890_abnormal_embryonic-extraembry	2.25257072
15	MP0002653_abnormal_ependyma_morphology	2.09919677
16	MP0002277_abnormal_respiratory_mucosa	1.86018007
17	MP0006276_abnormal_autonomic_nervous	1.84612462
18	MP0004133_heterotaxia	1.84400101
19	MP0003122_maternal_imprinting	1.81491355
20	MP0005645_abnormal_hypothalamus_physiol	1.81396114
21	MP0006035_abnormal_mitochondrial_morpho	1.70297158
22	MP0002234_abnormal_pharynx_morphology	1.69422740
23	MP0003693_abnormal_embryo_hatching	1.65613644
24	MP0005253_abnormal_eye_physiology	1.65492110
25	MP0002751_abnormal_autonomic_nervous	1.63804067
26	MP0002163_abnormal_gland_morphology	1.61142764
27	MP0005084_abnormal_gallbladder_morpholo	1.57531033
28	MP0000778_abnormal_nervous_system	1.57017372
29	MP0002822_catalepsy	1.56468822
30	MP0001984_abnormal_olfaction	1.56016505
31	MP0000631_abnormal_neuroendocrine_gland	1.51473320
32	MP0001293_anophthalmia	1.49455108
33	MP0008995_early_reproductive_senescence	1.48629769
34	MP0003195_calcinosis	1.44863434
35	MP0004142_abnormal_muscle_tone	1.38296013
36	MP0003123_paternal_imprinting	1.33032241
37	MP0001986_abnormal_taste_sensitivity	1.29696492
38	MP0010386_abnormal_urinary_bladder	1.29509585
39	MP0000049_abnormal_middle_ear	1.26079652
40	MP0002272_abnormal_nervous_system	1.21820176
41	MP0003938_abnormal_ear_development	1.19787085
42	MP0001905_abnormal_dopamine_level	1.16654612
43	MP0009745_abnormal_behavioral_response	1.14051130
44	MP0003786_premature_aging	1.13649892
45	MP0005551_abnormal_eye_electrophysiolog	1.13272394
46	MP0005075_abnormal_melanosome_morpholog	1.12374202
47	MP0002928_abnormal_bile_duct	1.10929550
48	MP0004147_increased_porphyrin_level	1.10064177
49	MP0002557_abnormal_social/conspecific_i	1.07052712
50	MP0003119_abnormal_digestive_system	1.06734423
51	MP0010094_abnormal_chromosome_stability	1.06479706
52	MP0003011_delayed_dark_adaptation	1.03478525
53	MP0000955_abnormal_spinal_cord	1.03225507
54	MP0005423_abnormal_somatic_nervous	1.02983434
55	MP0001764_abnormal_homeostasis	1.01879164
56	MP0002876_abnormal_thyroid_physiology	1.00786686
57	MP0002184_abnormal_innervation	0.99349430
58	MP0001919_abnormal_reproductive_system	0.98980127
59	MP0003718_maternal_effect	0.98359733
60	MP0008872_abnormal_physiological_respon	0.96119515
61	MP0001346_abnormal_lacrimal_gland	0.95776828
62	MP0002909_abnormal_adrenal_gland	0.95441640
63	MP0004742_abnormal_vestibular_system	0.93159810
64	MP0002210_abnormal_sex_determination	0.93063888
65	MP0002095_abnormal_skin_pigmentation	0.92303208
66	MP0002752_abnormal_somatic_nervous	0.92300834
67	MP0002638_abnormal_pupillary_reflex	0.92124098
68	MP0005379_endocrine/exocrine_gland_phen	0.91902324
69	MP0001486_abnormal_startle_reflex	0.90457360
70	MP0000427_abnormal_hair_cycle	0.90144771
71	MP0000647_abnormal_sebaceous_gland	0.89819379
72	MP0005391_vision/eye_phenotype	0.89713896
73	MP0002160_abnormal_reproductive_system	0.88879535
74	MP0002572_abnormal_emotion/affect_behav	0.87323643
75	MP0001929_abnormal_gametogenesis	0.86898994
76	MP0005389_reproductive_system_phenotype	0.85288484
77	MP0009046_muscle_twitch	0.85228961
78	MP0003283_abnormal_digestive_organ	0.83737872
79	MP0002882_abnormal_neuron_morphology	0.83712432
80	MP0003221_abnormal_cardiomyocyte_apopto	0.83601335
81	MP0005195_abnormal_posterior_eye	0.83187977
82	MP0005646_abnormal_pituitary_gland	0.81235869
83	MP0006036_abnormal_mitochondrial_physio	0.80717780
84	MP0001968_abnormal_touch/_nociception	0.80657596
85	MP0008875_abnormal_xenobiotic_pharmacok	0.80006074
86	MP0003698_abnormal_male_reproductive	0.79833477
87	MP0003635_abnormal_synaptic_transmissio	0.78955624
88	MP0002837_dystrophic_cardiac_calcinosis	0.78189878
89	MP0003077_abnormal_cell_cycle	0.77971921
90	MP0004924_abnormal_behavior	0.76636150
91	MP0005386_behavior/neurological_phenoty	0.76636150
92	MP0002063_abnormal_learning/memory/cond	0.76416691
93	MP0002233_abnormal_nose_morphology	0.75558933
94	MP0005083_abnormal_biliary_tract	0.75532177
95	MP0001286_abnormal_eye_development	0.75083742
96	MP0004811_abnormal_neuron_physiology	0.75027688
97	MP0002736_abnormal_nociception_after	0.72887627
98	MP0003567_abnormal_fetal_cardiomyocyte	0.72428037
99	MP0001324_abnormal_eye_pigmentation	0.70219055
100	MP0003861_abnormal_nervous_system	0.69370470

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	3.53953446
2	Abnormality of midbrain morphology (HP:0002418)	3.46548227
3	Molar tooth sign on MRI (HP:0002419)	3.46548227
4	Pancreatic cysts (HP:0001737)	3.24146623
5	Mitochondrial inheritance (HP:0001427)	3.09521324
6	Increased hepatocellular lipid droplets (HP:0006565)	3.04830812
7	Lipid accumulation in hepatocytes (HP:0006561)	2.91973796
8	Increased CSF lactate (HP:0002490)	2.89062693
9	Acute necrotizing encephalopathy (HP:0006965)	2.85905937
10	True hermaphroditism (HP:0010459)	2.84518710
11	Medial flaring of the eyebrow (HP:0010747)	2.83272286
12	Acute encephalopathy (HP:0006846)	2.78766927
13	Pancreatic fibrosis (HP:0100732)	2.78351710
14	Nephronophthisis (HP:0000090)	2.73155125
15	Methylmalonic acidemia (HP:0002912)	2.71692640
16	Hepatocellular necrosis (HP:0001404)	2.69083505
17	Colon cancer (HP:0003003)	2.68545384
18	Hepatic necrosis (HP:0002605)	2.64731486
19	Abnormal mitochondria in muscle tissue (HP:0008316)	2.61197968
20	Pendular nystagmus (HP:0012043)	2.51533544
21	3-Methylglutaconic aciduria (HP:0003535)	2.48982858
22	Congenital primary aphakia (HP:0007707)	2.43341429
23	Progressive macrocephaly (HP:0004481)	2.43080225
24	Chronic hepatic failure (HP:0100626)	2.40311127
25	Agitation (HP:0000713)	2.38959678
26	Gait imbalance (HP:0002141)	2.35925907
27	Nephrogenic diabetes insipidus (HP:0009806)	2.34815922
28	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.31920288
29	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.31920288
30	Renal Fanconi syndrome (HP:0001994)	2.30197014
31	Cortical dysplasia (HP:0002539)	2.27983706
32	Increased serum lactate (HP:0002151)	2.27366838
33	Methylmalonic aciduria (HP:0012120)	2.24810163
34	Anencephaly (HP:0002323)	2.22767604
35	Abnormality of the renal medulla (HP:0100957)	2.19969792
36	Hyperglycinemia (HP:0002154)	2.17816728
37	Abolished electroretinogram (ERG) (HP:0000550)	2.16881404
38	Abnormal biliary tract physiology (HP:0012439)	2.15113154
39	Bile duct proliferation (HP:0001408)	2.15113154
40	Hypothermia (HP:0002045)	2.14023477
41	Lissencephaly (HP:0001339)	2.09277420
42	Intestinal atresia (HP:0011100)	2.06631305
43	Vaginal atresia (HP:0000148)	2.03972885
44	Lactic acidosis (HP:0003128)	2.01194496
45	Medulloblastoma (HP:0002885)	2.00817469
46	Patellar aplasia (HP:0006443)	1.99811478
47	Genital tract atresia (HP:0001827)	1.99795278
48	Hepatoblastoma (HP:0002884)	1.96564829
49	Optic disc pallor (HP:0000543)	1.95937366
50	Volvulus (HP:0002580)	1.94616381
51	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.94546733
52	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.94546733
53	Preaxial hand polydactyly (HP:0001177)	1.93272183
54	Absent speech (HP:0001344)	1.93199151
55	Sclerocornea (HP:0000647)	1.88417687
56	Cerebral edema (HP:0002181)	1.88235702
57	Neoplasm of the adrenal cortex (HP:0100641)	1.88185442
58	Abnormality of the corticospinal tract (HP:0002492)	1.86610879
59	Specific learning disability (HP:0001328)	1.86469383
60	Increased intramyocellular lipid droplets (HP:0012240)	1.85606473
61	Rib fusion (HP:0000902)	1.84020685
62	Retinal dysplasia (HP:0007973)	1.83517653
63	Occipital encephalocele (HP:0002085)	1.81873073
64	Progressive inability to walk (HP:0002505)	1.81736219
65	Broad-based gait (HP:0002136)	1.81338230
66	Aplasia/Hypoplasia of the patella (HP:0006498)	1.80832613
67	Muscular hypotonia of the trunk (HP:0008936)	1.79707374
68	Tented upper lip vermilion (HP:0010804)	1.78956913
69	Drooling (HP:0002307)	1.78296357
70	Abnormality of renal resorption (HP:0011038)	1.78229278
71	Abnormality of serine family amino acid metabolism (HP:0010894)	1.77004205
72	Abnormality of glycine metabolism (HP:0010895)	1.77004205
73	Increased serum pyruvate (HP:0003542)	1.76831597
74	Abnormality of the renal cortex (HP:0011035)	1.74264024
75	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.73367712
76	Hyperalaninemia (HP:0003348)	1.72985536
77	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.72985536
78	Abnormality of alanine metabolism (HP:0010916)	1.72985536
79	Postaxial hand polydactyly (HP:0001162)	1.72634025
80	Renal cortical cysts (HP:0000803)	1.70681608
81	Type I transferrin isoform profile (HP:0003642)	1.70073448
82	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.69977177
83	Limb dystonia (HP:0002451)	1.69438039
84	Anophthalmia (HP:0000528)	1.68593102
85	Neoplasm of the adrenal gland (HP:0100631)	1.67544317
86	Dandy-Walker malformation (HP:0001305)	1.67522680
87	Cystic liver disease (HP:0006706)	1.65832379
88	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.65826437
89	Abnormal protein N-linked glycosylation (HP:0012347)	1.65826437
90	Abnormal protein glycosylation (HP:0012346)	1.65826437
91	Abnormal glycosylation (HP:0012345)	1.65826437
92	Stenosis of the external auditory canal (HP:0000402)	1.65094925
93	Optic nerve hypoplasia (HP:0000609)	1.64915333
94	Glycosuria (HP:0003076)	1.64884012
95	Abnormality of urine glucose concentration (HP:0011016)	1.64884012
96	Excessive salivation (HP:0003781)	1.64838511
97	Hyperglycinuria (HP:0003108)	1.64600339
98	Optic nerve coloboma (HP:0000588)	1.64419693
99	Inability to walk (HP:0002540)	1.64040876
100	Oligodactyly (hands) (HP:0001180)	1.63715062

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	4.01905352
2	BCR	3.28543460
3	NUAK1	2.97916475
4	SRPK1	2.73253711
5	MAP3K4	2.66218044
6	MAP2K7	2.61310960
7	WNK3	2.61147458
8	MAP4K2	2.60493277
9	VRK2	2.59361315
10	DYRK2	2.34645277
11	FRK	2.13053936
12	BUB1	2.04014606
13	BMPR1B	1.96379501
14	CSNK1G3	1.92762636
15	CSNK1G2	1.89552903
16	DYRK3	1.85369570
17	CSNK1A1L	1.84777991
18	STK16	1.78919975
19	ACVR1B	1.74095372
20	CASK	1.70212070
21	CSNK1G1	1.69344886
22	MAPK13	1.63750420
23	MARK1	1.62265552
24	STK38L	1.49506451
25	ADRBK2	1.44624283
26	MST4	1.41355425
27	VRK1	1.35693796
28	CDK19	1.32729559
29	TAOK3	1.30105306
30	SIK2	1.28675270
31	ZAK	1.28428779
32	NME1	1.24966674
33	SIK3	1.22514271
34	CDC7	1.19218843
35	TAF1	1.18535505
36	PINK1	1.18109510
37	ERBB3	1.13925216
38	GRK1	1.09504266
39	TNIK	1.03691255
40	PLK4	0.99339472
41	MAP2K4	0.94950146
42	BCKDK	0.92977820
43	PLK3	0.91233396
44	PLK1	0.90255829
45	EPHA4	0.90191974
46	EIF2AK3	0.89214309
47	TLK1	0.85847213
48	OXSR1	0.85152176
49	DYRK1B	0.75062261
50	PRKCG	0.72298858
51	MAP3K6	0.72232749
52	MINK1	0.66711594
53	BRSK2	0.65680539
54	ATR	0.65630963
55	CAMKK2	0.64746501
56	RPS6KA4	0.63490590
57	PAK3	0.62704420
58	INSRR	0.62150586
59	WEE1	0.60520874
60	TXK	0.60211740
61	CDK8	0.58643774
62	LIMK1	0.58219525
63	TSSK6	0.57798421
64	DYRK1A	0.57324050
65	MAP3K12	0.55700070
66	NTRK2	0.55221178
67	CDK3	0.49706439
68	FGFR2	0.49083318
69	AURKA	0.47135156
70	PRKCE	0.46726516
71	CCNB1	0.46492284
72	UHMK1	0.45421758
73	GRK6	0.45420210
74	SGK494	0.44495401
75	SGK223	0.44495401
76	PLK2	0.43967948
77	MAP3K5	0.43136668
78	PKN1	0.42560432
79	NEK1	0.42206588
80	STK24	0.42134708
81	TTK	0.41088491
82	SGK2	0.39313041
83	ATM	0.38512759
84	PBK	0.38438470
85	RPS6KA5	0.38327682
86	PDK2	0.37942497
87	AURKB	0.37330201
88	BRSK1	0.35720446
89	MAP3K11	0.34503206
90	WNK4	0.34401918
91	BRD4	0.34350377
92	DAPK1	0.33939179
93	CAMK4	0.33738750
94	CSNK2A1	0.32321487
95	CSNK2A2	0.31745855
96	PRKCZ	0.31505906
97	IKBKE	0.31448829
98	DAPK2	0.30939499
99	PRKCI	0.29569465
100	EIF2AK1	0.29228286

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.76585506
2	Proteasome_Homo sapiens_hsa03050	3.69329808
3	Parkinsons disease_Homo sapiens_hsa05012	3.13907404
4	Protein export_Homo sapiens_hsa03060	3.04620647
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.63921375
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.60172211
7	RNA polymerase_Homo sapiens_hsa03020	2.55462796
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.54866739
9	Huntingtons disease_Homo sapiens_hsa05016	2.25343884
10	Basal transcription factors_Homo sapiens_hsa03022	2.18015374
11	RNA degradation_Homo sapiens_hsa03018	2.10446608
12	Non-homologous end-joining_Homo sapiens_hsa03450	2.09976833
13	Fanconi anemia pathway_Homo sapiens_hsa03460	1.98011852
14	Homologous recombination_Homo sapiens_hsa03440	1.97923226
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.96202261
16	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.93693957
17	Mismatch repair_Homo sapiens_hsa03430	1.93487064
18	Alzheimers disease_Homo sapiens_hsa05010	1.93358895
19	Butanoate metabolism_Homo sapiens_hsa00650	1.89609896
20	Propanoate metabolism_Homo sapiens_hsa00640	1.88509848
21	Spliceosome_Homo sapiens_hsa03040	1.88420023
22	Nicotine addiction_Homo sapiens_hsa05033	1.86655751
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.74196548
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.68862713
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.56936135
26	Regulation of autophagy_Homo sapiens_hsa04140	1.55985297
27	Ribosome_Homo sapiens_hsa03010	1.55045636
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.43442676
29	Base excision repair_Homo sapiens_hsa03410	1.42392375
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.41444671
31	DNA replication_Homo sapiens_hsa03030	1.38634825
32	RNA transport_Homo sapiens_hsa03013	1.27208331
33	Caffeine metabolism_Homo sapiens_hsa00232	1.27094626
34	Phototransduction_Homo sapiens_hsa04744	1.23839988
35	Peroxisome_Homo sapiens_hsa04146	1.19236731
36	Cardiac muscle contraction_Homo sapiens_hsa04260	1.18562764
37	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.18429888
38	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.17568264
39	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.17477212
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.14439006
41	Selenocompound metabolism_Homo sapiens_hsa00450	1.03991372
42	Fatty acid elongation_Homo sapiens_hsa00062	1.01388422
43	Steroid biosynthesis_Homo sapiens_hsa00100	0.98899751
44	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.98788277
45	Purine metabolism_Homo sapiens_hsa00230	0.94166833
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.91728227
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.90557669
48	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.87423142
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.84679450
50	Sulfur relay system_Homo sapiens_hsa04122	0.84503893
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.83078230
52	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.81095760
53	Cell cycle_Homo sapiens_hsa04110	0.79694695
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.77221048
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.75534941
56	Taste transduction_Homo sapiens_hsa04742	0.75217353
57	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.73665222
58	Circadian rhythm_Homo sapiens_hsa04710	0.72805614
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72178119
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.69558405
61	GABAergic synapse_Homo sapiens_hsa04727	0.68556354
62	Metabolic pathways_Homo sapiens_hsa01100	0.67837815
63	Oocyte meiosis_Homo sapiens_hsa04114	0.62817393
64	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.60776054
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.57977038
66	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.56944947
67	Fatty acid metabolism_Homo sapiens_hsa01212	0.53439161
68	Folate biosynthesis_Homo sapiens_hsa00790	0.51522592
69	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.49773957
70	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.48893865
71	Morphine addiction_Homo sapiens_hsa05032	0.47537457
72	Dopaminergic synapse_Homo sapiens_hsa04728	0.47260963
73	Pyruvate metabolism_Homo sapiens_hsa00620	0.45174863
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.44473867
75	Fatty acid degradation_Homo sapiens_hsa00071	0.43861774
76	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.41663899
77	Cocaine addiction_Homo sapiens_hsa05030	0.41444439
78	Chemical carcinogenesis_Homo sapiens_hsa05204	0.40446871
79	Linoleic acid metabolism_Homo sapiens_hsa00591	0.40176021
80	mRNA surveillance pathway_Homo sapiens_hsa03015	0.40054818
81	p53 signaling pathway_Homo sapiens_hsa04115	0.38499950
82	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.38074333
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.37745857
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.36556958
85	Retinol metabolism_Homo sapiens_hsa00830	0.34658705
86	Primary immunodeficiency_Homo sapiens_hsa05340	0.33868064
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.33673292
88	Basal cell carcinoma_Homo sapiens_hsa05217	0.33250915
89	Glutamatergic synapse_Homo sapiens_hsa04724	0.32863437
90	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.32174774
91	Type I diabetes mellitus_Homo sapiens_hsa04940	0.29850866
92	Serotonergic synapse_Homo sapiens_hsa04726	0.29337617
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.29157189
94	Vibrio cholerae infection_Homo sapiens_hsa05110	0.28895741
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.27792977
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.27387871
97	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.25964414
98	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.25886757
99	Olfactory transduction_Homo sapiens_hsa04740	0.25860490
100	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.22936883

ZSCAN16

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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