ZSCAN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains several copies of zinc finger motif, which is commonly found in transcriptional regulatory proteins. Studies in mice show that this gene is expressed during embryonic development, and specifically in the testis in adult mice, suggesting that it may play a role in regulating genes in germ cells. Alternative splicing of this gene results in several transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.30984008
2pyrimidine nucleobase catabolic process (GO:0006208)5.14830631
3sequestering of actin monomers (GO:0042989)4.77776299
4cilium or flagellum-dependent cell motility (GO:0001539)4.44505732
5negative regulation of telomere maintenance (GO:0032205)4.33532354
6sperm motility (GO:0030317)4.33206829
7axonemal dynein complex assembly (GO:0070286)4.23944801
8replicative senescence (GO:0090399)4.22586372
9nucleobase catabolic process (GO:0046113)4.15350025
10acrosome reaction (GO:0007340)3.90442623
11multicellular organism reproduction (GO:0032504)3.86749436
12motile cilium assembly (GO:0044458)3.85882633
13cell differentiation involved in metanephros development (GO:0072202)3.84018497
14water-soluble vitamin biosynthetic process (GO:0042364)3.75473074
15regulation of nuclear cell cycle DNA replication (GO:0033262)3.69770587
16energy homeostasis (GO:0097009)3.65607377
17epithelial cilium movement (GO:0003351)3.57406321
18regulation of telomere maintenance (GO:0032204)3.57328910
19mesenchymal cell differentiation involved in renal system development (GO:2001012)3.56117280
20mesenchymal cell differentiation involved in kidney development (GO:0072161)3.56117280
21microtubule depolymerization (GO:0007019)3.54245717
22neural tube formation (GO:0001841)3.51539110
23negative regulation of mast cell activation (GO:0033004)3.49261554
24NADH dehydrogenase complex assembly (GO:0010257)3.47142819
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47142819
26mitochondrial respiratory chain complex I assembly (GO:0032981)3.47142819
27DNA damage response, detection of DNA damage (GO:0042769)3.46007195
28sperm-egg recognition (GO:0035036)3.43682054
29regulation of chromatin binding (GO:0035561)3.43104161
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.42979734
31tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.42979734
32centriole assembly (GO:0098534)3.38807824
33interferon-gamma production (GO:0032609)3.36736588
34protein complex biogenesis (GO:0070271)3.31089659
35acrosome assembly (GO:0001675)3.29128672
36regulation of posttranscriptional gene silencing (GO:0060147)3.28163269
37regulation of gene silencing by miRNA (GO:0060964)3.28163269
38regulation of gene silencing by RNA (GO:0060966)3.28163269
39protein polyglutamylation (GO:0018095)3.18960325
40negative regulation of translation, ncRNA-mediated (GO:0040033)3.18626984
41regulation of translation, ncRNA-mediated (GO:0045974)3.18626984
42negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.18626984
43cell-cell recognition (GO:0009988)3.17785060
44L-fucose catabolic process (GO:0042355)3.17190183
45fucose catabolic process (GO:0019317)3.17190183
46L-fucose metabolic process (GO:0042354)3.17190183
47ubiquinone metabolic process (GO:0006743)3.13619212
48reproduction (GO:0000003)3.13556953
49mitochondrial respiratory chain complex assembly (GO:0033108)3.13230677
50DNA damage induced protein phosphorylation (GO:0006975)3.11961184
51cell wall macromolecule catabolic process (GO:0016998)3.08123498
52cell wall macromolecule metabolic process (GO:0044036)3.08123498
53binding of sperm to zona pellucida (GO:0007339)3.05527540
54sulfate transport (GO:0008272)3.05524996
55cilium movement (GO:0003341)3.04902180
56histone H3-K36 demethylation (GO:0070544)3.04828319
57platelet dense granule organization (GO:0060155)3.04781324
58somatic hypermutation of immunoglobulin genes (GO:0016446)3.04176972
59somatic diversification of immune receptors via somatic mutation (GO:0002566)3.04176972
60regulation of dendritic cell antigen processing and presentation (GO:0002604)3.03560395
61regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03304661
62regulation of mitotic spindle checkpoint (GO:1903504)3.03304661
63DNA deamination (GO:0045006)3.02048768
64ubiquinone biosynthetic process (GO:0006744)2.99020368
65fusion of sperm to egg plasma membrane (GO:0007342)2.98436255
66pseudouridine synthesis (GO:0001522)2.98146800
67response to pheromone (GO:0019236)2.95848468
68regulation of male gonad development (GO:2000018)2.95813348
69replication fork processing (GO:0031297)2.95635023
70regulation of telomere maintenance via telomerase (GO:0032210)2.93707205
71base-excision repair, AP site formation (GO:0006285)2.92552890
72piRNA metabolic process (GO:0034587)2.92442998
73spermatid development (GO:0007286)2.90868698
74regulation of cilium movement (GO:0003352)2.89555477
75positive regulation of gamma-delta T cell activation (GO:0046645)2.89110736
76positive regulation of cellular amide metabolic process (GO:0034250)2.88467069
77termination of RNA polymerase III transcription (GO:0006386)2.87299255
78transcription elongation from RNA polymerase III promoter (GO:0006385)2.87299255
79respiratory chain complex IV assembly (GO:0008535)2.83525016
80modulation by virus of host process (GO:0019054)2.80213905
81seminiferous tubule development (GO:0072520)2.79770366
82negative regulation of transcription regulatory region DNA binding (GO:2000678)2.79285068
83behavioral response to ethanol (GO:0048149)2.75900229
84epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72021315
85presynaptic membrane assembly (GO:0097105)2.71083842
86RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.70953165
87negative regulation of glycogen biosynthetic process (GO:0045719)2.69323013
88dendritic cell chemotaxis (GO:0002407)2.68773194
89ganglion development (GO:0061548)2.68381344
90poly(A)+ mRNA export from nucleus (GO:0016973)2.66441896
91single fertilization (GO:0007338)2.64451665
92kidney morphogenesis (GO:0060993)2.64404654
93nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.63830024
94rRNA catabolic process (GO:0016075)2.63650315
95G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.63142738
96detection of molecule of bacterial origin (GO:0032490)2.61252602
97ncRNA catabolic process (GO:0034661)2.58994876
98retinal cone cell development (GO:0046549)2.58060619
99protein-cofactor linkage (GO:0018065)2.57719673
100DNA integration (GO:0015074)2.56917180
101synaptic transmission, cholinergic (GO:0007271)2.56482519
102exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.55934662
103DNA replication-dependent nucleosome organization (GO:0034723)2.53005824
104DNA replication-dependent nucleosome assembly (GO:0006335)2.53005824
105indolalkylamine metabolic process (GO:0006586)2.52744028
106negative regulation of glycogen metabolic process (GO:0070874)2.52646954
107tRNA processing (GO:0008033)2.52469503
108intraciliary transport (GO:0042073)2.52266430
109nonmotile primary cilium assembly (GO:0035058)2.51126316
110cornea development in camera-type eye (GO:0061303)2.49914867
111facial nerve structural organization (GO:0021612)2.49849392
112cytochrome complex assembly (GO:0017004)2.49394149
113regulation of glucokinase activity (GO:0033131)2.49135458
114regulation of hexokinase activity (GO:1903299)2.49135458
115sulfate transmembrane transport (GO:1902358)2.46986373
116negative regulation of DNA-dependent DNA replication (GO:2000104)2.46397586
117DNA modification (GO:0006304)2.45833244
118L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.44754356
119regulation of helicase activity (GO:0051095)2.43729928
120regulation of meiosis I (GO:0060631)2.43288830
121kynurenine metabolic process (GO:0070189)2.43014002
122receptor recycling (GO:0001881)2.42623396
123synapsis (GO:0007129)2.41884112
124protein neddylation (GO:0045116)2.41295879
125reciprocal meiotic recombination (GO:0007131)2.39882660
126reciprocal DNA recombination (GO:0035825)2.39882660
127preassembly of GPI anchor in ER membrane (GO:0016254)2.39562981
128DNA demethylation (GO:0080111)2.39441305
129histone H3-K9 demethylation (GO:0033169)2.39195529
130DNA methylation or demethylation (GO:0044728)2.38895076
131DNA strand renaturation (GO:0000733)2.38197854
132positive regulation of antigen processing and presentation (GO:0002579)2.37941616
133embryonic camera-type eye morphogenesis (GO:0048596)2.37848846
134tRNA methylation (GO:0030488)2.37642204
135peptidyl-histidine modification (GO:0018202)2.37552685
136DNA synthesis involved in DNA repair (GO:0000731)2.37445542
137* spermatogenesis (GO:0007283)2.35975282
138male meiosis (GO:0007140)2.35600426
139DNA methylation involved in gamete generation (GO:0043046)2.35484298
140single strand break repair (GO:0000012)2.35476645
141gamma-aminobutyric acid transport (GO:0015812)2.35007049
142* male gamete generation (GO:0048232)2.34968090
143positive regulation of male gonad development (GO:2000020)2.34409910
144cilium assembly (GO:0042384)2.34371624
145negative regulation of skeletal muscle tissue development (GO:0048642)2.33835870
146detection of other organism (GO:0098543)2.33366260
147regulation of DNA methylation (GO:0044030)2.33270939
148centriole replication (GO:0007099)2.33056576
149DNA alkylation (GO:0006305)2.33044802
150DNA methylation (GO:0006306)2.33044802
151cilium organization (GO:0044782)2.32167894
152establishment of protein localization to mitochondrial membrane (GO:0090151)2.32061978
153regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.31744548
154positive regulation of type 2 immune response (GO:0002830)2.31681620
155natural killer cell activation involved in immune response (GO:0002323)2.31564352
156positive T cell selection (GO:0043368)2.31379502
157tyrosine phosphorylation of STAT protein (GO:0007260)2.31044026
158presynaptic membrane organization (GO:0097090)2.30714608
159embryonic eye morphogenesis (GO:0048048)2.30680914
160metanephric mesenchyme development (GO:0072075)2.29581941
161regulation of interleukin-8 secretion (GO:2000482)2.28534698
162fertilization (GO:0009566)2.28483003
163pharyngeal system development (GO:0060037)2.27931612
164S-adenosylmethionine metabolic process (GO:0046500)2.27612364
165quinone biosynthetic process (GO:1901663)2.27180137
166pore complex assembly (GO:0046931)2.26767841
167transcription from RNA polymerase III promoter (GO:0006383)2.26472520
168neuronal action potential (GO:0019228)2.25432903
169plasma membrane fusion (GO:0045026)2.25365926
170regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.25212843
171iron-sulfur cluster assembly (GO:0016226)2.25074271
172metallo-sulfur cluster assembly (GO:0031163)2.25074271
173tRNA metabolic process (GO:0006399)2.24867954
174regulation of interleukin-12 biosynthetic process (GO:0045075)2.23769875
175histone H2A acetylation (GO:0043968)2.23549068
176histone deubiquitination (GO:0016578)2.23497561
177nephron tubule morphogenesis (GO:0072078)2.22006462
178nephron epithelium morphogenesis (GO:0072088)2.22006462
179histone H3-K4 trimethylation (GO:0080182)2.21384837
180organic cation transport (GO:0015695)2.21145221
181regulation of mast cell activation (GO:0033003)2.20929837
182superoxide anion generation (GO:0042554)2.20598116
183positive regulation of DNA recombination (GO:0045911)2.20362016
184regulation of antigen processing and presentation (GO:0002577)2.20357932
185response to peptidoglycan (GO:0032494)2.19140364
186DNA double-strand break processing (GO:0000729)2.18701854
187lipoxygenase pathway (GO:0019372)2.18686367

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.38274870
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.75757833
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.46575871
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.33878126
5* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.27835523
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.27149831
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.19401458
8IGF1R_20145208_ChIP-Seq_DFB_Human3.08733283
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.00049140
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.95420927
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.93373959
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.85064538
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.76246507
14VDR_22108803_ChIP-Seq_LS180_Human2.72649903
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.59141889
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.58942584
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.55859550
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.40859980
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.33941608
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.28014991
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.16744602
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.10832471
23EWS_26573619_Chip-Seq_HEK293_Human2.06702185
24PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06384239
25FUS_26573619_Chip-Seq_HEK293_Human2.02131278
26IRF1_19129219_ChIP-ChIP_H3396_Human2.02125400
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.96501348
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.91498852
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.90943731
30MYC_18940864_ChIP-ChIP_HL60_Human1.89824951
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.84430026
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83775751
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.81623693
34P300_19829295_ChIP-Seq_ESCs_Human1.80573100
35VDR_23849224_ChIP-Seq_CD4+_Human1.79914150
36SCL_19346495_ChIP-Seq_HPC-7_Human1.79359845
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76938682
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75944798
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74914311
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72090474
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70615687
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66526749
43TAF15_26573619_Chip-Seq_HEK293_Human1.63937098
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60362634
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60114694
46PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59763011
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56158133
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55513392
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54252209
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54238892
51FOXP3_21729870_ChIP-Seq_TREG_Human1.53706690
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52878158
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52606839
54RUNX_20019798_ChIP-Seq_JUKART_Human1.52382562
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51337077
56ELK1_19687146_ChIP-ChIP_HELA_Human1.50125322
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50050004
58TP53_22573176_ChIP-Seq_HFKS_Human1.49329844
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46770931
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46770931
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45486429
62GBX2_23144817_ChIP-Seq_PC3_Human1.45105545
63* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44353489
64RNF2_27304074_Chip-Seq_NSC_Mouse1.43092223
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39999262
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37551504
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36395257
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.35102941
69REST_21632747_ChIP-Seq_MESCs_Mouse1.34560624
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.33868209
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.33282501
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.33021650
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32339209
74IRF8_27001747_Chip-Seq_BMDM_Mouse1.31780119
75CBP_20019798_ChIP-Seq_JUKART_Human1.31462880
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31462880
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31398595
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.30061815
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29848820
80NMYC_18555785_Chip-Seq_ESCs_Mouse1.29732117
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.28662634
82RUNX1_26923725_Chip-Seq_HPCs_Mouse1.27451058
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26011037
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25699040
85ZFX_18555785_Chip-Seq_ESCs_Mouse1.25286585
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24870665
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24722135
88P53_22387025_ChIP-Seq_ESCs_Mouse1.24691861
89GF1_26923725_Chip-Seq_HPCs_Mouse1.24514094
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24480375
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24198775
92ER_23166858_ChIP-Seq_MCF-7_Human1.23247242
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23192529
94SRF_21415370_ChIP-Seq_HL-1_Mouse1.22976761
95EZH2_22144423_ChIP-Seq_EOC_Human1.21185120
96E2F4_17652178_ChIP-ChIP_JURKAT_Human1.20452340
97LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20085056
98EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19895782
99WDR5_24793694_ChIP-Seq_LNCAP_Human1.19325177
100ESRRB_18555785_Chip-Seq_ESCs_Mouse1.19272323
101PU1_27457419_Chip-Seq_LIVER_Mouse1.18548472
102OCT4_18555785_Chip-Seq_ESCs_Mouse1.18407211
103P300_18555785_Chip-Seq_ESCs_Mouse1.17470913
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16395861
105AHR_22903824_ChIP-Seq_MCF-7_Human1.16355720
106LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15271092
107NOTCH1_21737748_ChIP-Seq_TLL_Human1.14954437
108GF1B_26923725_Chip-Seq_HPCs_Mouse1.13957632
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13336318
110CMYC_18555785_Chip-Seq_ESCs_Mouse1.13250404
111SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13083457
112* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12947462
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12268732
114EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11997228
115STAT3_23295773_ChIP-Seq_U87_Human1.10941029
116SALL1_21062744_ChIP-ChIP_HESCs_Human1.10685765
117KLF4_18555785_Chip-Seq_ESCs_Mouse1.10011068
118SOX2_18555785_Chip-Seq_ESCs_Mouse1.09968103
119GATA1_26923725_Chip-Seq_HPCs_Mouse1.09965917
120TAL1_26923725_Chip-Seq_HPCs_Mouse1.09899588
121PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08822768
122NANOG_16153702_ChIP-ChIP_HESCs_Human1.08340975
123* MYB_26560356_Chip-Seq_TH2_Human1.08201438
124* TCF4_23295773_ChIP-Seq_U87_Human1.06881142
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06364007
126NANOG_19829295_ChIP-Seq_ESCs_Human1.05797354
127SOX2_19829295_ChIP-Seq_ESCs_Human1.05797354
128GABP_19822575_ChIP-Seq_HepG2_Human1.05660936
129STAT1_17558387_ChIP-Seq_HELA_Human1.05033693
130REST_18959480_ChIP-ChIP_MESCs_Mouse1.03964749
131RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03847131
132CTCF_18555785_Chip-Seq_ESCs_Mouse1.02523126
133OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02352140
134YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02007340
135ELK4_26923725_Chip-Seq_MESODERM_Mouse1.01576772
136FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01561238
137ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01299723
138CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01262070
139TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00716703
140CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99606281
141* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98699502
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98367053
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97766736
144FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97712841
145FOXA1_25329375_ChIP-Seq_VCAP_Human0.97712841
146MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97464016
147BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97354270
148* MYB_26560356_Chip-Seq_TH1_Human0.97044248
149CRX_20693478_ChIP-Seq_RETINA_Mouse0.96774422
150AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96733203
151TCF4_22108803_ChIP-Seq_LS180_Human0.96087435
152GATA3_21878914_ChIP-Seq_MCF-7_Human0.94225528
153PIAS1_25552417_ChIP-Seq_VCAP_Human0.93996027
154* AR_20517297_ChIP-Seq_VCAP_Human0.93931166
155FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93611767
156SMAD4_21799915_ChIP-Seq_A2780_Human0.93549495
157RUNX2_22187159_ChIP-Seq_PCA_Human0.93467291
158NCOR_22424771_ChIP-Seq_293T_Human0.93197596
159NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93061997
160* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.92443191
161POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91515455
162BCAT_22108803_ChIP-Seq_LS180_Human0.91147080
163* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91103139
164AR_25329375_ChIP-Seq_VCAP_Human0.90854150
165THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90770849
166ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90644381
167HOXB7_26014856_ChIP-Seq_BT474_Human0.90408517
168STAT3_18555785_ChIP-Seq_MESCs_Mouse0.90356705
169PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90034238
170SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90021385
171PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89620658
172* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.89277656
173CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88783267
174TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88588425
175ARNT_22903824_ChIP-Seq_MCF-7_Human0.87467048

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization3.40180471
2MP0006292_abnormal_olfactory_placode3.24600572
3MP0008789_abnormal_olfactory_epithelium3.22938515
4MP0003787_abnormal_imprinting3.14177263
5MP0005394_taste/olfaction_phenotype2.94207369
6MP0005499_abnormal_olfactory_system2.94207369
7MP0000015_abnormal_ear_pigmentation2.88573969
8MP0008058_abnormal_DNA_repair2.72681276
9MP0002102_abnormal_ear_morphology2.65637538
10MP0002132_abnormal_respiratory_system2.53184632
11MP0001529_abnormal_vocalization2.47706005
12MP0001835_abnormal_antigen_presentation2.39717635
13MP0000678_abnormal_parathyroid_gland2.29153827
14MP0008877_abnormal_DNA_methylation2.25708994
15MP0003718_maternal_effect2.08270868
16MP0003122_maternal_imprinting2.03963251
17MP0008007_abnormal_cellular_replicative2.01041621
18MP0004133_heterotaxia1.94800596
19MP0003880_abnormal_central_pattern1.94060044
20MP0006072_abnormal_retinal_apoptosis1.92870791
21MP0005171_absent_coat_pigmentation1.92566005
22MP0000569_abnormal_digit_pigmentation1.90074261
23MP0003763_abnormal_thymus_physiology1.89848735
24MP0002254_reproductive_system_inflammat1.87402319
25MP0006276_abnormal_autonomic_nervous1.86648986
26MP0005551_abnormal_eye_electrophysiolog1.80044607
27MP0003567_abnormal_fetal_cardiomyocyte1.79899032
28MP0001984_abnormal_olfaction1.78267531
29MP0002822_catalepsy1.75338625
30MP0005671_abnormal_response_to1.75202263
31MP0003941_abnormal_skin_development1.72908971
32MP0008995_early_reproductive_senescence1.69223673
33MP0002009_preneoplasia1.68732836
34MP0003693_abnormal_embryo_hatching1.66712397
35MP0002163_abnormal_gland_morphology1.64980541
36MP0002751_abnormal_autonomic_nervous1.62525288
37MP0001968_abnormal_touch/_nociception1.61931477
38MP0004142_abnormal_muscle_tone1.60783934
39MP0002160_abnormal_reproductive_system1.60474094
40MP0003195_calcinosis1.60423578
41MP0005645_abnormal_hypothalamus_physiol1.57220773
42MP0005084_abnormal_gallbladder_morpholo1.54686221
43MP0001293_anophthalmia1.54639386
44MP0001188_hyperpigmentation1.54602678
45MP0002928_abnormal_bile_duct1.52653058
46MP0001986_abnormal_taste_sensitivity1.51191800
47MP0000566_synostosis1.48438352
48MP0002148_abnormal_hypersensitivity_rea1.48311575
49MP0003136_yellow_coat_color1.48043528
50MP0010386_abnormal_urinary_bladder1.45513352
51MP0002837_dystrophic_cardiac_calcinosis1.43897251
52MP0002736_abnormal_nociception_after1.43100055
53MP0000631_abnormal_neuroendocrine_gland1.41371637
54MP0005174_abnormal_tail_pigmentation1.40911424
55MP0003698_abnormal_male_reproductive1.40664488
56MP0005075_abnormal_melanosome_morpholog1.40342996
57MP0009785_altered_susceptibility_to1.39749405
58MP0000778_abnormal_nervous_system1.39528876
59MP0005387_immune_system_phenotype1.39321512
60MP0001790_abnormal_immune_system1.39321512
61MP0008872_abnormal_physiological_respon1.39279224
62MP0001929_abnormal_gametogenesis1.39094301
63MP0002277_abnormal_respiratory_mucosa1.36909637
64MP0002138_abnormal_hepatobiliary_system1.35836808
65MP0005389_reproductive_system_phenotype1.35638061
66MP0003786_premature_aging1.35583217
67MP0009278_abnormal_bone_marrow1.32306973
68MP0005253_abnormal_eye_physiology1.30186149
69MP0001486_abnormal_startle_reflex1.28196265
70MP0001485_abnormal_pinna_reflex1.28178213
71MP0002938_white_spotting1.25353294
72MP0002272_abnormal_nervous_system1.25255441
73MP0003646_muscle_fatigue1.24850676
74MP0010030_abnormal_orbit_morphology1.24373661
75MP0001186_pigmentation_phenotype1.22440346
76MP0005503_abnormal_tendon_morphology1.21498923
77MP0009745_abnormal_behavioral_response1.20990223
78MP0002095_abnormal_skin_pigmentation1.19955729
79MP0002405_respiratory_system_inflammati1.19231033
80MP0002638_abnormal_pupillary_reflex1.18271363
81MP0005248_abnormal_Harderian_gland1.17915594
82MP0004145_abnormal_muscle_electrophysio1.16858797
83MP0002877_abnormal_melanocyte_morpholog1.16813307
84MP0002210_abnormal_sex_determination1.15978929
85MP0003119_abnormal_digestive_system1.15942704
86MP0002735_abnormal_chemical_nociception1.15643775
87MP0004808_abnormal_hematopoietic_stem1.15269940
88MP0001324_abnormal_eye_pigmentation1.14497283
89MP0003123_paternal_imprinting1.13672491
90MP0002557_abnormal_social/conspecific_i1.13236453
91MP0000371_diluted_coat_color1.12093040
92MP0001919_abnormal_reproductive_system1.12055985
93MP0004885_abnormal_endolymph1.11021932
94MP0004742_abnormal_vestibular_system1.10913396
95MP0001119_abnormal_female_reproductive1.10418044
96MP0005379_endocrine/exocrine_gland_phen1.10358859
97MP0002396_abnormal_hematopoietic_system1.09440925
98MP0002234_abnormal_pharynx_morphology1.09430505
99MP0006082_CNS_inflammation1.09258953
100MP0003121_genomic_imprinting1.08743224
101MP0003111_abnormal_nucleus_morphology1.07757732
102MP0002452_abnormal_antigen_presenting1.07535638
103MP0005646_abnormal_pituitary_gland1.07131301
104MP0001819_abnormal_immune_cell1.06947742
105MP0003943_abnormal_hepatobiliary_system1.06810675
106MP0002184_abnormal_innervation1.06445234
107MP0002420_abnormal_adaptive_immunity1.06441473
108MP0002752_abnormal_somatic_nervous1.05695484
109MP0010094_abnormal_chromosome_stability1.05568135
110MP0001800_abnormal_humoral_immune1.04778709
111MP0005367_renal/urinary_system_phenotyp1.03401870
112MP0000516_abnormal_urinary_system1.03401870
113MP0002398_abnormal_bone_marrow1.03268206
114MP0009697_abnormal_copulation1.02631713
115MP0003279_aneurysm1.02223203
116MP0009046_muscle_twitch1.00997337
117MP0008057_abnormal_DNA_replication1.00628441
118MP0003011_delayed_dark_adaptation1.00079844
119MP0003937_abnormal_limbs/digits/tail_de0.99234262
120MP0003385_abnormal_body_wall0.98954931
121MP0002572_abnormal_emotion/affect_behav0.98499513
122MP0005386_behavior/neurological_phenoty0.97535374
123MP0004924_abnormal_behavior0.97535374
124MP0002723_abnormal_immune_serum0.97230216
125MP0000703_abnormal_thymus_morphology0.96576544
126MP0005195_abnormal_posterior_eye0.96205077
127MP0005025_abnormal_response_to0.95642187
128MP0002067_abnormal_sensory_capabilities0.95551937
129MP0002233_abnormal_nose_morphology0.95211962
130MP0005377_hearing/vestibular/ear_phenot0.95109498
131MP0003878_abnormal_ear_physiology0.95109498
132MP0000685_abnormal_immune_system0.94820672
133MP0002419_abnormal_innate_immunity0.94737121
134MP0002733_abnormal_thermal_nociception0.94685820
135MP0003635_abnormal_synaptic_transmissio0.93366160
136MP0002653_abnormal_ependyma_morphology0.93209345
137MP0002998_abnormal_bone_remodeling0.91381398
138MP0004147_increased_porphyrin_level0.90999118
139MP0000716_abnormal_immune_system0.90939325
140MP0000955_abnormal_spinal_cord0.90767755
141MP0002249_abnormal_larynx_morphology0.89983049
142MP0006035_abnormal_mitochondrial_morpho0.88310152
143MP0000372_irregular_coat_pigmentation0.88158612
144MP0002075_abnormal_coat/hair_pigmentati0.87608705
145MP0003137_abnormal_impulse_conducting0.87104359
146MP0001286_abnormal_eye_development0.86977612
147MP0000049_abnormal_middle_ear0.86841628
148MP0005257_abnormal_intraocular_pressure0.86264819
149MP0002876_abnormal_thyroid_physiology0.86134636
150MP0004782_abnormal_surfactant_physiolog0.85853789
151MP0002063_abnormal_learning/memory/cond0.84653235
152MP0002006_tumorigenesis0.83934394
153MP0005000_abnormal_immune_tolerance0.82626598
154MP0000653_abnormal_sex_gland0.82193308
155MP0003861_abnormal_nervous_system0.82051338
156MP0002177_abnormal_outer_ear0.81907077
157MP0001970_abnormal_pain_threshold0.81404101
158MP0008875_abnormal_xenobiotic_pharmacok0.78439969
159MP0002734_abnormal_mechanical_nocicepti0.77260466
160MP0005464_abnormal_platelet_physiology0.77258910
161MP0002882_abnormal_neuron_morphology0.77214224
162MP0001145_abnormal_male_reproductive0.74782305
163MP0010155_abnormal_intestine_physiology0.73406906
164MP0005409_darkened_coat_color0.72861809
165MP0003890_abnormal_embryonic-extraembry0.71214810
166MP0003942_abnormal_urinary_system0.70855330
167MP0009764_decreased_sensitivity_to0.70272099
168MP0003077_abnormal_cell_cycle0.68240196

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.91098667
2Absent/shortened dynein arms (HP:0200106)4.04742227
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.04742227
4Abnormality of the labia minora (HP:0012880)3.80488630
5Stomach cancer (HP:0012126)3.72934707
6Neoplasm of the adrenal cortex (HP:0100641)3.71744854
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.60070692
8Optic neuritis (HP:0100653)3.46625305
9Retrobulbar optic neuritis (HP:0100654)3.46625305
10True hermaphroditism (HP:0010459)3.36383717
11Abnormal respiratory epithelium morphology (HP:0012253)3.33022762
12Abnormal respiratory motile cilium morphology (HP:0005938)3.33022762
13Abnormal respiratory motile cilium physiology (HP:0012261)3.21913525
14Chromsome breakage (HP:0040012)3.01584301
15Colon cancer (HP:0003003)2.90415069
16Orchitis (HP:0100796)2.87583938
17Lissencephaly (HP:0001339)2.75791523
18Pancreatic fibrosis (HP:0100732)2.74527940
19Abnormality of the renal cortex (HP:0011035)2.72398455
20Papillary thyroid carcinoma (HP:0002895)2.62146311
21Abolished electroretinogram (ERG) (HP:0000550)2.59020637
22Abnormal ciliary motility (HP:0012262)2.57120487
23Myositis (HP:0100614)2.56009940
24Type II lissencephaly (HP:0007260)2.55636540
25Occipital encephalocele (HP:0002085)2.55586295
26Renal cortical cysts (HP:0000803)2.55275575
27Abnormal delayed hypersensitivity skin test (HP:0002963)2.54266007
28Nephronophthisis (HP:0000090)2.52706981
29Chronic hepatic failure (HP:0100626)2.48295428
30Broad-based gait (HP:0002136)2.47957264
31Rhinitis (HP:0012384)2.46929885
32Progressive inability to walk (HP:0002505)2.46451009
33Prostate neoplasm (HP:0100787)2.45949561
34Cystic liver disease (HP:0006706)2.45633572
35Methylmalonic acidemia (HP:0002912)2.45229649
36Inability to walk (HP:0002540)2.44461497
37Abnormality of the renal medulla (HP:0100957)2.42777464
38Intestinal atresia (HP:0011100)2.42615698
39Attenuation of retinal blood vessels (HP:0007843)2.41633029
40Hyperglycinemia (HP:0002154)2.37761432
41Pendular nystagmus (HP:0012043)2.35191262
42Syringomyelia (HP:0003396)2.33946664
43Spinal cord lesions (HP:0100561)2.33946664
44Sclerocornea (HP:0000647)2.31826868
45Gait imbalance (HP:0002141)2.31144469
46Congenital hepatic fibrosis (HP:0002612)2.29910541
47Postaxial foot polydactyly (HP:0001830)2.29607313
48Osteomalacia (HP:0002749)2.28499522
49Anencephaly (HP:0002323)2.26331319
50Acute necrotizing encephalopathy (HP:0006965)2.25089351
51Hypothermia (HP:0002045)2.24142150
52Alveolar cell carcinoma (HP:0006519)2.22055168
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.21926312
54Hypoplasia of the fovea (HP:0007750)2.21926312
55Pachygyria (HP:0001302)2.20529269
56Polyphagia (HP:0002591)2.19645521
57Congenital primary aphakia (HP:0007707)2.17409433
58Protruding tongue (HP:0010808)2.15221491
59Genital tract atresia (HP:0001827)2.13673859
60Increased CSF lactate (HP:0002490)2.13491060
61Patellar aplasia (HP:0006443)2.13045807
62Methylmalonic aciduria (HP:0012120)2.12497667
63Mitochondrial inheritance (HP:0001427)2.11873539
64Pancreatic cysts (HP:0001737)2.11351992
65Hyperglycinuria (HP:0003108)2.10330916
66Chronic bronchitis (HP:0004469)2.09467819
67Lipid accumulation in hepatocytes (HP:0006561)2.08431427
68Optic nerve coloboma (HP:0000588)2.08029273
69Acute encephalopathy (HP:0006846)2.07367049
70Abnormality of DNA repair (HP:0003254)2.07262912
71Clubbing of toes (HP:0100760)2.06862489
72Volvulus (HP:0002580)2.06382257
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06127873
74Abnormality of alanine metabolism (HP:0010916)2.06127873
75Hyperalaninemia (HP:0003348)2.06127873
76Bilateral microphthalmos (HP:0007633)2.05283985
77Tented upper lip vermilion (HP:0010804)2.04883609
78Increased hepatocellular lipid droplets (HP:0006565)2.04802906
79Neoplasm of the tracheobronchial system (HP:0100552)2.04358878
80Medial flaring of the eyebrow (HP:0010747)2.03358126
81Abnormality of serine family amino acid metabolism (HP:0010894)2.02396783
82Abnormality of glycine metabolism (HP:0010895)2.02396783
83Supernumerary spleens (HP:0009799)2.02348576
84Glomerulopathy (HP:0100820)2.02197238
85Aplasia/Hypoplasia of the uvula (HP:0010293)2.01970853
86Vaginal atresia (HP:0000148)2.01688210
87Aplasia/Hypoplasia of the tongue (HP:0010295)2.00651004
88Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00089924
89Renal dysplasia (HP:0000110)2.00029107
90Hypoplasia of the pons (HP:0012110)1.99380526
91Abnormal mitochondria in muscle tissue (HP:0008316)1.98944948
92Hepatoblastoma (HP:0002884)1.97969141
93Ectopic kidney (HP:0000086)1.97318068
94Abnormality of the intervertebral disk (HP:0005108)1.96837072
95Recurrent cutaneous fungal infections (HP:0011370)1.96209560
96Chronic mucocutaneous candidiasis (HP:0002728)1.96209560
97Abnormal rod and cone electroretinograms (HP:0008323)1.96174331
98Aplasia/Hypoplasia of the spleen (HP:0010451)1.95131936
99Aplasia/Hypoplasia of the patella (HP:0006498)1.95125901
100Abnormality of the renal collecting system (HP:0004742)1.94643372
101Dandy-Walker malformation (HP:0001305)1.94255726
102Facial cleft (HP:0002006)1.91868735
103Male pseudohermaphroditism (HP:0000037)1.91865224
104Septo-optic dysplasia (HP:0100842)1.91766530
105Tubulointerstitial nephritis (HP:0001970)1.91254648
106Abnormality of the pons (HP:0007361)1.91093954
107Recurrent abscess formation (HP:0002722)1.90969458
108Albinism (HP:0001022)1.90663082
109Tubular atrophy (HP:0000092)1.90642822
110Scrotal hypoplasia (HP:0000046)1.90070990
111Panhypogammaglobulinemia (HP:0003139)1.89041597
112Hyperventilation (HP:0002883)1.88967605
113Preaxial hand polydactyly (HP:0001177)1.87661886
114Progressive macrocephaly (HP:0004481)1.87301712
115Retinal dysplasia (HP:0007973)1.86599070
116Optic nerve hypoplasia (HP:0000609)1.86507430
117Bronchiectasis (HP:0002110)1.85829176
118Decreased central vision (HP:0007663)1.85363174
119Abnormal biliary tract physiology (HP:0012439)1.84024229
120Bile duct proliferation (HP:0001408)1.84024229
121Absent eyebrow (HP:0002223)1.83857266
122Failure to thrive in infancy (HP:0001531)1.83506476
123Abnormality of midbrain morphology (HP:0002418)1.83232837
124Molar tooth sign on MRI (HP:0002419)1.83232837
125Asplenia (HP:0001746)1.82728648
126Median cleft lip (HP:0000161)1.82324452
127Oligodactyly (hands) (HP:0001180)1.80068571
128Renovascular hypertension (HP:0100817)1.80067678
129Bell-shaped thorax (HP:0001591)1.79935339
130Bronchitis (HP:0012387)1.79915859
131Drooling (HP:0002307)1.79283213
132Hepatocellular necrosis (HP:0001404)1.78413286
133Keratoconjunctivitis sicca (HP:0001097)1.77834856
134Abnormality of the carotid arteries (HP:0005344)1.77265102
135Embryonal neoplasm (HP:0002898)1.76806138
136Optic disc pallor (HP:0000543)1.76606696
137Bony spicule pigmentary retinopathy (HP:0007737)1.76463924
138Poor suck (HP:0002033)1.76173945
139Congenital stationary night blindness (HP:0007642)1.76072849
140Recurrent sinusitis (HP:0011108)1.75954226
141Increased serum lactate (HP:0002151)1.75664694
142Decreased muscle mass (HP:0003199)1.75578468
143Abnormality of the ileum (HP:0001549)1.75298540
144Aplasia/Hypoplasia of the tibia (HP:0005772)1.74960893
145Increased IgM level (HP:0003496)1.74602006
146Encephalitis (HP:0002383)1.74351552
147Abnormality of male internal genitalia (HP:0000022)1.73360894
148Gaze-evoked nystagmus (HP:0000640)1.71065844
149Anophthalmia (HP:0000528)1.70861834
150Abnormal hair whorl (HP:0010721)1.69549964
151Polymicrogyria (HP:0002126)1.69530852
152Meckel diverticulum (HP:0002245)1.69033710
153Type 2 muscle fiber atrophy (HP:0003554)1.68950860
154Postaxial hand polydactyly (HP:0001162)1.68711476
155Neoplasm of the lung (HP:0100526)1.68595155
156Narrow forehead (HP:0000341)1.68363339
157Cheilitis (HP:0100825)1.68325081
158Abnormal drinking behavior (HP:0030082)1.67769596
159Polydipsia (HP:0001959)1.67769596
160Specific learning disability (HP:0001328)1.67336597
161Cerebellar dysplasia (HP:0007033)1.67219843
162Nephrogenic diabetes insipidus (HP:0009806)1.66624762
163Abnormality of the prostate (HP:0008775)1.65536774
164Deep philtrum (HP:0002002)1.65405565
165Meningitis (HP:0001287)1.63299379
166Aplasia/Hypoplasia of the macula (HP:0008059)1.62245967
167Prominent metopic ridge (HP:0005487)1.62051283
168Nasal polyposis (HP:0100582)1.61616433
169Thyroid carcinoma (HP:0002890)1.60794250
170Recurrent bronchitis (HP:0002837)1.60214553
171Keratitis (HP:0000491)1.60149069
172Elfin facies (HP:0004428)1.60085989
173Aplasia/Hypoplasia of the lens (HP:0008063)1.60001772
174Keratoconjunctivitis (HP:0001096)1.59843582
175Aortic valve stenosis (HP:0001650)1.59682702

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK5.51878806
2TXK3.38031437
3WNK33.11540784
4FRK3.05803548
5MAP4K22.89184217
6ERBB32.87124210
7TNIK2.60233869
8DYRK22.45628903
9TRIM282.41182747
10MAP3K142.39287451
11SGK22.15873139
12TAOK22.10362564
13MAP3K42.09960840
14IRAK32.04643295
15YES12.03111857
16VRK22.02026154
17TLK12.00297406
18BMPR21.99301655
19PINK11.88314334
20IRAK41.86925974
21AKT31.76082585
22MAP2K71.75854231
23SIK31.73052309
24VRK11.69701373
25SGK31.64724474
26IKBKE1.62201369
27ACVR1B1.62100259
28PRKD31.53251153
29BCKDK1.51511997
30PLK41.50926650
31CDC71.50499803
32WNK41.49590084
33TESK11.47559930
34INSRR1.46616592
35ICK1.45192392
36TNK21.45015130
37CHUK1.41438435
38PDK21.39676351
39TSSK61.39079738
40BCR1.37656695
41STK38L1.36390697
42BRD41.32765886
43CDK191.29850583
44CSNK1G21.27937687
45PRPF4B1.25503551
46TAF11.24034777
47CSNK1G11.23507152
48CDK31.22607121
49JAK31.21965538
50CSNK1G31.21284183
51ADRBK21.18435485
52DAPK21.17148692
53BTK1.17026619
54SGK4941.14273171
55SGK2231.14273171
56TEC1.13504254
57STK161.13485711
58ATR1.12502214
59PDK31.11675901
60PDK41.11675901
61MAP4K11.10423819
62IKBKB1.09043298
63CAMKK21.07628000
64NLK1.07088768
65PIM11.06369933
66FLT31.01256738
67ZAP701.00339376
68MAPK150.99259862
69TTK0.98853830
70PIM20.96691482
71CSNK1A1L0.95339794
72NEK90.95290220
73NEK20.94624119
74TAOK30.93429270
75MKNK20.93340213
76CAMK1D0.93069832
77OXSR10.91496387
78PRKCG0.91214757
79CLK10.91152784
80NUAK10.90917080
81PASK0.89553755
82PHKG20.88426426
83PHKG10.88426426
84CDK120.85473127
85SRPK10.85116637
86TIE10.85040298
87BMPR1B0.84666634
88EPHA30.84265083
89MAPK130.82395447
90PLK10.80764607
91DYRK30.80612226
92GRK10.79969400
93MAPK70.78980437
94IRAK10.78690147
95CCNB10.78013276
96TRPM70.75626073
97PRKCH0.75316813
98EIF2AK20.75186900
99LATS10.74518110
100RPS6KB10.74400908
101MARK10.73621435
102PRKCE0.72480826
103PAK30.71803053
104BRSK20.71795161
105DYRK1B0.70916357
106NTRK20.70619262
107NME10.69667288
108MKNK10.69104815
109FGFR30.68761616
110TYK20.67843600
111MUSK0.67642407
112CASK0.67285052
113NEK60.66420012
114OBSCN0.65130836
115HIPK20.64772929
116STK30.64647515
117RPS6KA20.63413620
118BUB10.62247941
119RPS6KA60.62071810
120KIT0.61232409
121STK380.61112188
122TGFBR10.61043165
123CHEK20.60684985
124RPS6KC10.60200121
125RPS6KL10.60200121
126RPS6KA50.59992777
127PRKD20.59255911
128PRKCI0.59139508
129IRAK20.58780648
130EIF2AK30.56727141
131STK390.56005695
132TBK10.55660706
133JAK10.55528325
134MAPKAPK50.55360994
135ATM0.54761550
136STK240.54629767
137ADRBK10.53381446
138CAMK1G0.51971142
139DYRK1A0.51884945
140STK40.51792839
141CDK90.51640462
142CSNK1A10.49752588
143CAMK10.49366125
144RPS6KA40.49324367
145PLK20.48248046
146HCK0.48006090
147CAMK40.47547340
148DAPK10.47032289
149MAP2K60.46826182
150MAP3K50.46633163
151MAP3K30.46127905
152CSNK1D0.45929653
153CSNK1E0.45200778
154PLK30.45115026
155MAPK30.45062790
156GRK70.44746532
157PRKCZ0.43691889
158ITK0.43651869
159MAPK80.43192018
160SIK20.40775184
161MAPKAPK30.38085512
162PKN10.36004521
163PRKAA10.35751276
164PRKACA0.35501723
165MST40.35272093
166PRKCQ0.35081529
167FGFR20.33418516
168AURKA0.33290166
169PRKDC0.32731839

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030202.81305901
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.46844153
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.42639899
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.37652917
5Primary immunodeficiency_Homo sapiens_hsa053402.33772205
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.22947928
7Oxidative phosphorylation_Homo sapiens_hsa001902.20062187
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.18491222
9Graft-versus-host disease_Homo sapiens_hsa053322.15249727
10Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.08922295
11Fanconi anemia pathway_Homo sapiens_hsa034602.03900616
12Base excision repair_Homo sapiens_hsa034102.01235892
13Steroid biosynthesis_Homo sapiens_hsa001001.98813043
14Butanoate metabolism_Homo sapiens_hsa006501.98220923
15Parkinsons disease_Homo sapiens_hsa050121.96529753
16Nicotine addiction_Homo sapiens_hsa050331.95835575
17Measles_Homo sapiens_hsa051621.91164306
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88397911
19Protein export_Homo sapiens_hsa030601.87288869
20Propanoate metabolism_Homo sapiens_hsa006401.81911594
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73378934
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72302404
23Allograft rejection_Homo sapiens_hsa053301.65261799
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63893505
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.63002693
26Proteasome_Homo sapiens_hsa030501.60355283
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60115096
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.59074713
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58354364
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.57114748
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55148754
32RNA transport_Homo sapiens_hsa030131.52381897
33Autoimmune thyroid disease_Homo sapiens_hsa053201.49844253
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49706084
35Legionellosis_Homo sapiens_hsa051341.46990827
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38340308
37Herpes simplex infection_Homo sapiens_hsa051681.38224110
38One carbon pool by folate_Homo sapiens_hsa006701.38167074
39Ether lipid metabolism_Homo sapiens_hsa005651.37369846
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36846010
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.36460513
42Huntingtons disease_Homo sapiens_hsa050161.34644731
43Tryptophan metabolism_Homo sapiens_hsa003801.32040779
44Influenza A_Homo sapiens_hsa051641.30589372
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26582000
46Notch signaling pathway_Homo sapiens_hsa043301.24588792
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19145850
48Pyrimidine metabolism_Homo sapiens_hsa002401.17135954
49mRNA surveillance pathway_Homo sapiens_hsa030151.16559878
50Leishmaniasis_Homo sapiens_hsa051401.16218433
51Spliceosome_Homo sapiens_hsa030401.15918813
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.15918589
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15040731
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12960251
55Arachidonic acid metabolism_Homo sapiens_hsa005901.11476784
56Endometrial cancer_Homo sapiens_hsa052131.10617665
57Cardiac muscle contraction_Homo sapiens_hsa042601.09359641
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08620142
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08516238
60Antigen processing and presentation_Homo sapiens_hsa046121.07912966
61Hematopoietic cell lineage_Homo sapiens_hsa046401.07671316
62T cell receptor signaling pathway_Homo sapiens_hsa046601.07337634
63Jak-STAT signaling pathway_Homo sapiens_hsa046301.07260416
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05682841
65Toxoplasmosis_Homo sapiens_hsa051451.05594712
66Retinol metabolism_Homo sapiens_hsa008301.05477560
67TNF signaling pathway_Homo sapiens_hsa046681.04828837
68Basal transcription factors_Homo sapiens_hsa030221.03669498
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02564042
70Prolactin signaling pathway_Homo sapiens_hsa049171.02377709
71Chemical carcinogenesis_Homo sapiens_hsa052041.02335254
72Peroxisome_Homo sapiens_hsa041461.01706117
73Homologous recombination_Homo sapiens_hsa034400.99345444
74Ribosome_Homo sapiens_hsa030100.99327928
75Adherens junction_Homo sapiens_hsa045200.98068279
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96881779
77Phototransduction_Homo sapiens_hsa047440.96429443
78Apoptosis_Homo sapiens_hsa042100.96259964
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96079344
80Caffeine metabolism_Homo sapiens_hsa002320.94383479
81Pyruvate metabolism_Homo sapiens_hsa006200.93464635
82Alzheimers disease_Homo sapiens_hsa050100.93216590
83Osteoclast differentiation_Homo sapiens_hsa043800.93038717
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.92326961
85beta-Alanine metabolism_Homo sapiens_hsa004100.92115650
86Viral myocarditis_Homo sapiens_hsa054160.90819446
87HTLV-I infection_Homo sapiens_hsa051660.90532146
88Regulation of autophagy_Homo sapiens_hsa041400.87509867
89Nitrogen metabolism_Homo sapiens_hsa009100.87250731
90Morphine addiction_Homo sapiens_hsa050320.86996274
91Chemokine signaling pathway_Homo sapiens_hsa040620.86491734
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84910670
93Acute myeloid leukemia_Homo sapiens_hsa052210.84077324
94Non-homologous end-joining_Homo sapiens_hsa034500.83943015
95Linoleic acid metabolism_Homo sapiens_hsa005910.82494045
96Metabolic pathways_Homo sapiens_hsa011000.80276643
97Rheumatoid arthritis_Homo sapiens_hsa053230.79829777
98p53 signaling pathway_Homo sapiens_hsa041150.79379676
99GABAergic synapse_Homo sapiens_hsa047270.78079231
100Chronic myeloid leukemia_Homo sapiens_hsa052200.76825185
101Hepatitis B_Homo sapiens_hsa051610.76671302
102B cell receptor signaling pathway_Homo sapiens_hsa046620.75868037
103Other glycan degradation_Homo sapiens_hsa005110.75861845
104DNA replication_Homo sapiens_hsa030300.73169133
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73100710
106Serotonergic synapse_Homo sapiens_hsa047260.73047699
107Basal cell carcinoma_Homo sapiens_hsa052170.71889807
108Vitamin B6 metabolism_Homo sapiens_hsa007500.71752554
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70413427
110Asthma_Homo sapiens_hsa053100.70066287
111Vitamin digestion and absorption_Homo sapiens_hsa049770.70035967
112Mismatch repair_Homo sapiens_hsa034300.69234688
113FoxO signaling pathway_Homo sapiens_hsa040680.68738959
114Colorectal cancer_Homo sapiens_hsa052100.68505130
115Starch and sucrose metabolism_Homo sapiens_hsa005000.68336289
116Cell cycle_Homo sapiens_hsa041100.67761305
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67452468
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67182817
119Type I diabetes mellitus_Homo sapiens_hsa049400.66491901
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66235035
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65330499
122Sulfur relay system_Homo sapiens_hsa041220.64891912
123RNA degradation_Homo sapiens_hsa030180.64291100
124ABC transporters_Homo sapiens_hsa020100.64244270
125Tuberculosis_Homo sapiens_hsa051520.63678976
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63516673
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.63190026
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63087892
129Nucleotide excision repair_Homo sapiens_hsa034200.62515748
130Prostate cancer_Homo sapiens_hsa052150.62165791
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.61067168
132Wnt signaling pathway_Homo sapiens_hsa043100.58211275
133Glutamatergic synapse_Homo sapiens_hsa047240.57189821
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56762491
135Pertussis_Homo sapiens_hsa051330.55318574
136Circadian rhythm_Homo sapiens_hsa047100.55243643
137Fatty acid elongation_Homo sapiens_hsa000620.55078776
138Hepatitis C_Homo sapiens_hsa051600.54813503
139Lysine degradation_Homo sapiens_hsa003100.54388044
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53869731
141Sulfur metabolism_Homo sapiens_hsa009200.52607777
142Insulin secretion_Homo sapiens_hsa049110.51521584
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50615435
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49507627
145Collecting duct acid secretion_Homo sapiens_hsa049660.49100022
146Staphylococcus aureus infection_Homo sapiens_hsa051500.49087738
1472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48303218
148Salmonella infection_Homo sapiens_hsa051320.47313191
149Circadian entrainment_Homo sapiens_hsa047130.47023292
150Olfactory transduction_Homo sapiens_hsa047400.46138902
151Taste transduction_Homo sapiens_hsa047420.45615462
152Fatty acid degradation_Homo sapiens_hsa000710.45221745
153Purine metabolism_Homo sapiens_hsa002300.44741613
154Malaria_Homo sapiens_hsa051440.43723583
155Arginine and proline metabolism_Homo sapiens_hsa003300.43682180
156Pancreatic cancer_Homo sapiens_hsa052120.43212205
157Cocaine addiction_Homo sapiens_hsa050300.43111606
158Selenocompound metabolism_Homo sapiens_hsa004500.42834260
159Epstein-Barr virus infection_Homo sapiens_hsa051690.42761332
160Glycerolipid metabolism_Homo sapiens_hsa005610.42541141
161Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39708041
162Dopaminergic synapse_Homo sapiens_hsa047280.39492114
163Ovarian steroidogenesis_Homo sapiens_hsa049130.39356563
164Axon guidance_Homo sapiens_hsa043600.37785103
165Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37470107
166Fat digestion and absorption_Homo sapiens_hsa049750.36662908

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