ZSCAN20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of fibroblast apoptotic process (GO:2000269)8.41927817
2positive regulation of transcription from RNA polymerase III promoter (GO:0045945)7.63887831
3protein-cofactor linkage (GO:0018065)7.58983508
4L-serine metabolic process (GO:0006563)7.25898173
5microtubule nucleation (GO:0007020)7.18026535
6homocysteine metabolic process (GO:0050667)6.90036018
7white fat cell differentiation (GO:0050872)6.85688863
8proline biosynthetic process (GO:0006561)6.33756964
9negative regulation of osteoblast proliferation (GO:0033689)6.26381957
10tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.23338570
11RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.23338570
12regulation of plasminogen activation (GO:0010755)6.09868510
13neurotransmitter-gated ion channel clustering (GO:0072578)6.05696308
14folic acid-containing compound biosynthetic process (GO:0009396)5.76471553
15sulfur amino acid catabolic process (GO:0000098)5.75088467
16cysteine metabolic process (GO:0006534)5.59906893
17negative regulation of keratinocyte proliferation (GO:0010839)5.33538618
18snRNA processing (GO:0016180)5.22295823
19serine family amino acid biosynthetic process (GO:0009070)5.20009854
20mitochondrial RNA metabolic process (GO:0000959)5.19302091
21nuclear pore complex assembly (GO:0051292)5.13223007
22regulation of histone H3-K9 methylation (GO:0051570)5.03384956
23piRNA metabolic process (GO:0034587)4.86678485
24inner ear receptor cell development (GO:0060119)4.78830375
25nuclear pore organization (GO:0006999)4.64951522
26snRNA metabolic process (GO:0016073)4.62562770
27epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.61754460
28adenosine metabolic process (GO:0046085)4.58471955
29mitotic sister chromatid cohesion (GO:0007064)4.56158127
30proline metabolic process (GO:0006560)4.53798716
31pre-miRNA processing (GO:0031054)4.44847286
32negative regulation of histone methylation (GO:0031061)4.34441545
33rRNA methylation (GO:0031167)4.13937299
34pteridine-containing compound biosynthetic process (GO:0042559)4.09840847
35platelet dense granule organization (GO:0060155)4.09278642
36meiotic chromosome segregation (GO:0045132)4.02443008
37cochlea development (GO:0090102)4.02120195
38retinal rod cell development (GO:0046548)3.91808404
39positive regulation of gamma-delta T cell activation (GO:0046645)3.88825989
40pore complex assembly (GO:0046931)3.85777002
41purine nucleotide salvage (GO:0032261)3.76458862
42regulation of gonadotropin secretion (GO:0032276)3.73859808
43neural crest cell development (GO:0014032)3.73182803
44desmosome organization (GO:0002934)3.73091627
45gene silencing by RNA (GO:0031047)3.71956938
46positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.71682091
47regulation of transcription from RNA polymerase III promoter (GO:0006359)3.70649805
48negative regulation of DNA biosynthetic process (GO:2000279)3.66914493
49positive regulation of endothelial cell differentiation (GO:0045603)3.59242651
50growth hormone secretion (GO:0030252)3.52368773
51intestinal epithelial cell development (GO:0060576)3.48188287
52heterochromatin organization (GO:0070828)3.47292219
53protein neddylation (GO:0045116)3.45041921
54cell migration involved in heart development (GO:0060973)3.41766914
55acrosome assembly (GO:0001675)3.41247747
56positive thymic T cell selection (GO:0045059)3.36871771
57cartilage morphogenesis (GO:0060536)3.34370780
58chromosome condensation (GO:0030261)3.32659331
59gamma-aminobutyric acid transport (GO:0015812)3.30669219
60binding of sperm to zona pellucida (GO:0007339)3.29548312
61regulation of vitamin D biosynthetic process (GO:0060556)3.29422309
62tongue development (GO:0043586)3.29248198
63tRNA modification (GO:0006400)3.27362874
64sperm-egg recognition (GO:0035036)3.25857160
65gene silencing (GO:0016458)3.25790442
66histone H3-K36 demethylation (GO:0070544)3.25773958
67chromatin assembly (GO:0031497)3.25550330
68DNA packaging (GO:0006323)3.24292021
69synaptonemal complex assembly (GO:0007130)3.22118045
70behavioral response to nicotine (GO:0035095)3.20882018
71protein localization to chromosome, centromeric region (GO:0071459)3.19680031
72organic cation transport (GO:0015695)3.19439462
73regulation of gamma-delta T cell differentiation (GO:0045586)3.19015923
74cell-cell recognition (GO:0009988)3.17630971
75determination of adult lifespan (GO:0008340)3.17222043
76regulation of meiosis I (GO:0060631)3.17079379
77alternative mRNA splicing, via spliceosome (GO:0000380)3.16342654
78DNA methylation involved in gamete generation (GO:0043046)3.15431814
79cilium or flagellum-dependent cell motility (GO:0001539)3.14449640
80cerebral cortex radially oriented cell migration (GO:0021799)3.12868862
81adult feeding behavior (GO:0008343)3.11574179
82RNA stabilization (GO:0043489)3.11354804
83mRNA stabilization (GO:0048255)3.11354804
84galactose catabolic process (GO:0019388)3.11087570
85rRNA modification (GO:0000154)3.08177889
86behavioral defense response (GO:0002209)3.07888662
87behavioral fear response (GO:0001662)3.07888662
88regulation of lipoprotein metabolic process (GO:0050746)3.05325320
89folic acid-containing compound metabolic process (GO:0006760)3.04305548
90regulation of gamma-delta T cell activation (GO:0046643)3.03679295
91mitotic chromosome condensation (GO:0007076)3.02244956
92regulation of keratinocyte proliferation (GO:0010837)3.00886373
93kinetochore organization (GO:0051383)3.00347753
94regulation of sequestering of triglyceride (GO:0010889)2.99110725
95regulation of histone methylation (GO:0031060)2.97771796
96male meiosis (GO:0007140)2.97421325
97negative T cell selection (GO:0043383)2.96375029
98thymic T cell selection (GO:0045061)2.96164000
99negative thymic T cell selection (GO:0045060)2.95285236
100regulation of B cell receptor signaling pathway (GO:0050855)2.95000581
101response to lipoprotein particle (GO:0055094)2.94151533
102IMP biosynthetic process (GO:0006188)2.93216896
103synaptonemal complex organization (GO:0070193)2.93139564
104somatic diversification of immune receptors via somatic mutation (GO:0002566)2.93074951
105somatic hypermutation of immunoglobulin genes (GO:0016446)2.93074951
106adaptation of signaling pathway (GO:0023058)2.93052637
107somatic recombination of immunoglobulin gene segments (GO:0016447)2.92221083
108protein localization to kinetochore (GO:0034501)2.92146279
109lipid translocation (GO:0034204)2.91592447
110phospholipid translocation (GO:0045332)2.91592447
111regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.91483878
112mature B cell differentiation (GO:0002335)2.89854029
113multicellular organism reproduction (GO:0032504)2.89579096
114mitotic nuclear envelope disassembly (GO:0007077)2.89341091
115response to UV-C (GO:0010225)2.88562954
116negative regulation of Ras GTPase activity (GO:0034261)2.88270836
117pericardium development (GO:0060039)2.88235871
118DNA methylation (GO:0006306)2.88186761
119DNA alkylation (GO:0006305)2.88186761
120somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.88133022
121isotype switching (GO:0045190)2.88133022
122somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.88133022
123COPII vesicle coating (GO:0048208)2.87941446
124replication fork processing (GO:0031297)2.87057318
125regulation of endothelial cell differentiation (GO:0045601)2.86486889
126maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85457380
127histone H2A monoubiquitination (GO:0035518)2.85419093
128mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.83422306
129positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.83422306
130seminiferous tubule development (GO:0072520)2.82850698
131cytoplasmic mRNA processing body assembly (GO:0033962)2.81951630
132cell wall macromolecule catabolic process (GO:0016998)2.81736008
133regulation of RNA export from nucleus (GO:0046831)2.81211917
134folic acid transport (GO:0015884)2.81153177
135regulation of mitotic spindle organization (GO:0060236)2.78644096
136chromosome organization involved in meiosis (GO:0070192)2.76551356
137DNA duplex unwinding (GO:0032508)2.76201552
138nuclear envelope disassembly (GO:0051081)2.75750305
139membrane disassembly (GO:0030397)2.75750305
140DNA geometric change (GO:0032392)2.75596980
141stem cell development (GO:0048864)2.75303612
142positive regulation of histone methylation (GO:0031062)2.75256569
143polyamine biosynthetic process (GO:0006596)2.75090622
144regulation of sister chromatid cohesion (GO:0007063)2.74425979
145alpha-amino acid biosynthetic process (GO:1901607)2.74256899
146regulation of mRNA stability (GO:0043488)2.73769301
147T cell selection (GO:0045058)2.73651956
148heme transport (GO:0015886)2.73247117
149B cell receptor signaling pathway (GO:0050853)2.73230555
150histone H3-K9 methylation (GO:0051567)2.73107607
151histone H3-K9 modification (GO:0061647)2.72880733
152positive regulation of muscle hypertrophy (GO:0014742)2.72742650
153positive regulation of cardiac muscle hypertrophy (GO:0010613)2.72742650
154DNA conformation change (GO:0071103)2.72696821
155tetrahydrofolate metabolic process (GO:0046653)2.72188651
156negative regulation of translation, ncRNA-mediated (GO:0040033)2.71768724
157regulation of translation, ncRNA-mediated (GO:0045974)2.71768724
158negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.71768724
159fear response (GO:0042596)2.70855197
160mitotic sister chromatid segregation (GO:0000070)2.70620463
161regulation of spindle organization (GO:0090224)2.69640107
162sister chromatid cohesion (GO:0007062)2.69588708
163glutamine family amino acid biosynthetic process (GO:0009084)2.68019113
164positive T cell selection (GO:0043368)2.67929559
165monoubiquitinated protein deubiquitination (GO:0035520)2.67797724
166somatic diversification of immunoglobulins (GO:0016445)2.67751445
167DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.67689289
168lymph vessel development (GO:0001945)2.66964342
169NLS-bearing protein import into nucleus (GO:0006607)2.65963097
170phosphatidylglycerol biosynthetic process (GO:0006655)2.65862543
171placenta development (GO:0001890)2.65427799
172pteridine-containing compound metabolic process (GO:0042558)2.65268277
173phospholipid homeostasis (GO:0055091)2.64614808
174sister chromatid segregation (GO:0000819)2.64062705
175regulation of RNA stability (GO:0043487)2.61935868
176galactose metabolic process (GO:0006012)2.61931875
177somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.61154008
178somatic cell DNA recombination (GO:0016444)2.61154008
179peptidyl-proline hydroxylation (GO:0019511)2.60064783
180cellular response to zinc ion (GO:0071294)2.60011691
181fusion of sperm to egg plasma membrane (GO:0007342)2.59616866
182antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.58735477
183spindle assembly (GO:0051225)2.58246786
184protein-chromophore linkage (GO:0018298)2.58051183
185regulation of vitamin metabolic process (GO:0030656)2.57770622
186serine family amino acid metabolic process (GO:0009069)2.57456489
187protein localization to chromosome (GO:0034502)2.56761792
188negative regulation of histone modification (GO:0031057)2.56345956
189histone mRNA catabolic process (GO:0071044)2.54681122
190natural killer cell mediated immunity (GO:0002228)2.54618075
191natural killer cell mediated cytotoxicity (GO:0042267)2.54618075
192negative regulation of chromatin modification (GO:1903309)2.54450271
193histone lysine demethylation (GO:0070076)2.54375049
194DNA replication-dependent nucleosome organization (GO:0034723)2.53415285
195DNA replication-dependent nucleosome assembly (GO:0006335)2.53415285
196negative regulation of fibroblast apoptotic process (GO:2000270)11.1518150

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse9.56080348
2E2F7_22180533_ChIP-Seq_HELA_Human8.35020528
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.31418906
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.43468736
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.36988605
6EZH2_22144423_ChIP-Seq_EOC_Human3.83515731
7MYC_22102868_ChIP-Seq_BL_Human3.14634736
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.12337221
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.06968566
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.95245153
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.88097246
12ZNF274_21170338_ChIP-Seq_K562_Hela2.84496314
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67166358
14GBX2_23144817_ChIP-Seq_PC3_Human2.65405901
15VDR_22108803_ChIP-Seq_LS180_Human2.59795204
16FUS_26573619_Chip-Seq_HEK293_Human2.59597844
17TAF15_26573619_Chip-Seq_HEK293_Human2.51577109
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.30290019
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.27845741
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.22733079
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.21931234
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17537821
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.15652397
24KLF5_20875108_ChIP-Seq_MESCs_Mouse2.08399815
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.08369884
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.05980396
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02314091
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99811766
29P300_19829295_ChIP-Seq_ESCs_Human1.98808155
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.98595012
31VDR_21846776_ChIP-Seq_THP-1_Human1.98552165
32CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.97350009
33* MYB_26560356_Chip-Seq_TH2_Human1.95678117
34EWS_26573619_Chip-Seq_HEK293_Human1.92101731
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.90010961
36TCF7_22412390_ChIP-Seq_EML_Mouse1.89129614
37ER_23166858_ChIP-Seq_MCF-7_Human1.88278006
38* MYB_26560356_Chip-Seq_TH1_Human1.85764996
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85291378
40* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.83728810
41* UTX_26944678_Chip-Seq_JUKART_Human1.82468464
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.76348697
43TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.76229329
44* STAT3_23295773_ChIP-Seq_U87_Human1.74724634
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.72762702
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70107175
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67499491
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66877447
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64107843
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.62676802
51SCL_19346495_ChIP-Seq_HPC-7_Human1.62418701
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62038800
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61322886
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60401734
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59563537
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.57817157
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57816091
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55689622
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54917988
60CDX2_22108803_ChIP-Seq_LS180_Human1.54667502
61* PIAS1_25552417_ChIP-Seq_VCAP_Human1.54345966
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52787684
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51507019
64CIITA_25753668_ChIP-Seq_RAJI_Human1.51053374
65AR_21572438_ChIP-Seq_LNCaP_Human1.50264097
66SMAD4_21799915_ChIP-Seq_A2780_Human1.49788562
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48460383
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48251501
69KDM2B_26808549_Chip-Seq_REH_Human1.48228788
70RUNX2_22187159_ChIP-Seq_PCA_Human1.46176229
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45551288
72* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45381375
73* CBP_20019798_ChIP-Seq_JUKART_Human1.45381375
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.44321599
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43729520
76* MAF_26560356_Chip-Seq_TH1_Human1.43548375
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42045560
78TP53_22573176_ChIP-Seq_HFKS_Human1.41670611
79TCF4_22108803_ChIP-Seq_LS180_Human1.40416421
80AR_25329375_ChIP-Seq_VCAP_Human1.38579468
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36181685
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35518028
83TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.32475095
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32012734
85TP53_18474530_ChIP-ChIP_U2OS_Human1.30984389
86IRF8_27001747_Chip-Seq_BMDM_Mouse1.30656965
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28202792
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26321930
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25408939
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.23272045
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22946662
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.22772266
93BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22297065
94MYC_18555785_ChIP-Seq_MESCs_Mouse1.21285341
95OCT1_27270436_Chip-Seq_PROSTATE_Human1.21202385
96BCAT_22108803_ChIP-Seq_LS180_Human1.20699708
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.20519577
98ESR1_20079471_ChIP-ChIP_T-47D_Human1.19389737
99* TBL1_22424771_ChIP-Seq_293T_Human1.18240240
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17067801
101RUNX1_22412390_ChIP-Seq_EML_Mouse1.16975368
102NCOR1_26117541_ChIP-Seq_K562_Human1.16829353
103* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15880853
104MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15717406
105KDM2B_26808549_Chip-Seq_DND41_Human1.15468100
106RUNX_20019798_ChIP-Seq_JUKART_Human1.15263606
107TCF4_23295773_ChIP-Seq_U87_Human1.15131706
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14554873
109* NCOR_22424771_ChIP-Seq_293T_Human1.13966720
110IRF8_21731497_ChIP-ChIP_J774_Mouse1.13931746
111MAF_26560356_Chip-Seq_TH2_Human1.13856030
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13204284
113ERG_20517297_ChIP-Seq_VCAP_Human1.13132956
114EZH2_27294783_Chip-Seq_NPCs_Mouse1.13132791
115* NFYB_21822215_ChIP-Seq_K562_Human1.12594067
116SPI1_23127762_ChIP-Seq_K562_Human1.11870443
117PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11743514
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11396573
119GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11316551
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10086623
121NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09815019
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.09752723
123CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09015590
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08317834
125VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07225472
126STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06763721
127RXR_22108803_ChIP-Seq_LS180_Human1.05646683
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05065428
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04809634
130AR_21909140_ChIP-Seq_LNCAP_Human1.04761031
131* NFYA_21822215_ChIP-Seq_K562_Human1.04459176
132RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03901631
133GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.02417178
134RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01637056
135MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01106377
136CBP_21632823_ChIP-Seq_H3396_Human0.99591510
137PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99100154
138* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98077072
139POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97739976
140RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97514193
141TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97076796
142E2F1_17053090_ChIP-ChIP_MCF-7_Human0.96975733
143GATA3_27048872_Chip-Seq_THYMUS_Human0.95589833
144HOXB7_26014856_ChIP-Seq_BT474_Human0.94979487
145MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94683678
146* SPI1_23547873_ChIP-Seq_NB4_Human0.94415999
147BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.93560265
148TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92901863
149SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.92639738
150VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92036566
151POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91234570
152TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90576498
153SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90065673
154TP53_22127205_ChIP-Seq_IMR90_Human0.89990559
155SMAD3_21741376_ChIP-Seq_EPCs_Human0.89842922
156NANOG_19829295_ChIP-Seq_ESCs_Human0.89472209
157SOX2_19829295_ChIP-Seq_ESCs_Human0.89472209
158NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88890345
159FLI1_27457419_Chip-Seq_LIVER_Mouse0.88315791
160FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88212295
161JUN_21703547_ChIP-Seq_K562_Human0.87739083
162CBX2_27304074_Chip-Seq_ESCs_Mouse0.87657571
163BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87505009
164SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87249155
165VDR_24763502_ChIP-Seq_THP-1_Human0.87169992
166MYC_19030024_ChIP-ChIP_MESCs_Mouse0.87039569
167* PHF8_20622853_ChIP-Seq_HELA_Human0.86699503
168TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85898242
169STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85897792
170BRD4_25478319_ChIP-Seq_HGPS_Human0.85658985
171LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.85647295
172KAP1_27257070_Chip-Seq_ESCs_Mouse0.83915967
173KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83446237
174KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82270582
175RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81163455
176ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81013489
177SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79442437
178ELK4_26923725_Chip-Seq_MESODERM_Mouse0.79124004
179NANOG_21062744_ChIP-ChIP_HESCs_Human0.79066827
180* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.77682018
181KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76618140
182TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76571480
183MYB_21317192_ChIP-Seq_ERMYB_Mouse0.75739541
184KDM5A_27292631_Chip-Seq_BREAST_Human0.74901464
185PCGF2_27294783_Chip-Seq_NPCs_Mouse0.74778798
186FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.74687956
187HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.72254894
188LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.71594496
189ELF1_20517297_ChIP-Seq_JURKAT_Human0.71438085
190FOXP3_21729870_ChIP-Seq_TREG_Human0.71390228
191MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.70394179
192FOXO3_23340844_ChIP-Seq_DLD1_Human0.69188960

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005646_abnormal_pituitary_gland3.54969786
2MP0004885_abnormal_endolymph3.40046662
3MP0008877_abnormal_DNA_methylation3.30210906
4MP0000013_abnormal_adipose_tissue3.17894961
5MP0005367_renal/urinary_system_phenotyp3.17016331
6MP0000516_abnormal_urinary_system3.17016331
7MP0003283_abnormal_digestive_organ3.09870229
8MP0005410_abnormal_fertilization2.91029290
9MP0005360_urolithiasis2.89381710
10MP0005257_abnormal_intraocular_pressure2.65780577
11MP0008057_abnormal_DNA_replication2.65039258
12MP0010352_gastrointestinal_tract_polyps2.62868223
13MP0002736_abnormal_nociception_after2.58787466
14MP0010094_abnormal_chromosome_stability2.55584702
15MP0003111_abnormal_nucleus_morphology2.47921733
16MP0002396_abnormal_hematopoietic_system2.35048412
17MP0004147_increased_porphyrin_level2.33146703
18MP0003183_abnormal_peptide_metabolism2.30027701
19MP0001800_abnormal_humoral_immune2.26820550
20MP0006292_abnormal_olfactory_placode2.25850556
21MP0003077_abnormal_cell_cycle2.22491314
22MP0003693_abnormal_embryo_hatching2.19175164
23MP0000685_abnormal_immune_system2.17963807
24MP0003300_gastrointestinal_ulcer2.10594656
25MP0003763_abnormal_thymus_physiology2.05719745
26MP0008058_abnormal_DNA_repair1.97080473
27MP0009053_abnormal_anal_canal1.93193166
28MP0001929_abnormal_gametogenesis1.87398701
29MP0003646_muscle_fatigue1.86311941
30MP0005387_immune_system_phenotype1.85962288
31MP0001790_abnormal_immune_system1.85962288
32MP0005076_abnormal_cell_differentiation1.83496688
33MP0008995_early_reproductive_senescence1.79852180
34MP0002398_abnormal_bone_marrow1.76740437
35MP0001835_abnormal_antigen_presentation1.74618502
36MP0002452_abnormal_antigen_presenting1.73986125
37MP0010368_abnormal_lymphatic_system1.72063157
38MP0004808_abnormal_hematopoietic_stem1.70694959
39MP0000490_abnormal_crypts_of1.69365694
40MP0002938_white_spotting1.67321208
41MP0003942_abnormal_urinary_system1.66493181
42MP0001968_abnormal_touch/_nociception1.65404424
43MP0000703_abnormal_thymus_morphology1.64790080
44MP0005551_abnormal_eye_electrophysiolog1.61607275
45MP0004957_abnormal_blastocyst_morpholog1.61339178
46MP0000613_abnormal_salivary_gland1.61287032
47MP0000026_abnormal_inner_ear1.60266180
48MP0003566_abnormal_cell_adhesion1.56848792
49MP0000689_abnormal_spleen_morphology1.56646161
50MP0002210_abnormal_sex_determination1.50635337
51MP0000383_abnormal_hair_follicle1.50286527
52MP0001661_extended_life_span1.49527416
53MP0003698_abnormal_male_reproductive1.49181767
54MP0000631_abnormal_neuroendocrine_gland1.48502334
55MP0001485_abnormal_pinna_reflex1.47536345
56MP0002138_abnormal_hepatobiliary_system1.47457829
57MP0004742_abnormal_vestibular_system1.46612562
58MP0002722_abnormal_immune_system1.46140238
59MP0001270_distended_abdomen1.46083620
60MP0001730_embryonic_growth_arrest1.45753878
61MP0002420_abnormal_adaptive_immunity1.45367047
62MP0000716_abnormal_immune_system1.44821877
63MP0002723_abnormal_immune_serum1.44119016
64MP0000350_abnormal_cell_proliferation1.44024846
65MP0000537_abnormal_urethra_morphology1.43906785
66MP0010307_abnormal_tumor_latency1.43880139
67MP0005671_abnormal_response_to1.43032328
68MP0001346_abnormal_lacrimal_gland1.42117659
69MP0001819_abnormal_immune_cell1.41858515
70MP0001986_abnormal_taste_sensitivity1.41850660
71MP0010155_abnormal_intestine_physiology1.41024078
72MP0004510_myositis1.39720475
73MP0003252_abnormal_bile_duct1.37488872
74MP0005332_abnormal_amino_acid1.37289905
75MP0005380_embryogenesis_phenotype1.36170141
76MP0001672_abnormal_embryogenesis/_devel1.36170141
77MP0005253_abnormal_eye_physiology1.33493227
78MP0001486_abnormal_startle_reflex1.33286073
79MP0000569_abnormal_digit_pigmentation1.32575924
80MP0003935_abnormal_craniofacial_develop1.30676305
81MP0001764_abnormal_homeostasis1.29162572
82MP0005397_hematopoietic_system_phenotyp1.28877629
83MP0001545_abnormal_hematopoietic_system1.28877629
84MP0001873_stomach_inflammation1.28250850
85MP0002234_abnormal_pharynx_morphology1.28159373
86MP0002429_abnormal_blood_cell1.27583285
87MP0004133_heterotaxia1.27420475
88MP0005408_hypopigmentation1.27318480
89MP0001963_abnormal_hearing_physiology1.27147485
90MP0000534_abnormal_ureter_morphology1.26763037
91MP0000003_abnormal_adipose_tissue1.26288464
92MP0002837_dystrophic_cardiac_calcinosis1.24365675
93MP0001145_abnormal_male_reproductive1.23754846
94MP0002697_abnormal_eye_size1.23441641
95MP0002405_respiratory_system_inflammati1.21280937
96MP0003705_abnormal_hypodermis_morpholog1.21129885
97MP0003315_abnormal_perineum_morphology1.20159135
98MP0004130_abnormal_muscle_cell1.18471385
99MP0002277_abnormal_respiratory_mucosa1.18119816
100MP0008872_abnormal_physiological_respon1.18118959
101MP0005000_abnormal_immune_tolerance1.17080547
102MP0009278_abnormal_bone_marrow1.16032775
103MP0000762_abnormal_tongue_morphology1.15343051
104MP0001529_abnormal_vocalization1.15295992
105MP0003787_abnormal_imprinting1.15051983
106MP0003984_embryonic_growth_retardation1.12718365
107MP0002088_abnormal_embryonic_growth/wei1.12424325
108MP0002084_abnormal_developmental_patter1.12232618
109MP0003937_abnormal_limbs/digits/tail_de1.10795179
110MP0003890_abnormal_embryonic-extraembry1.10722664
111MP0003866_abnormal_defecation1.10460259
112MP0000653_abnormal_sex_gland1.10457352
113MP0004233_abnormal_muscle_weight1.10404631
114MP0002019_abnormal_tumor_incidence1.09863966
115MP0003755_abnormal_palate_morphology1.09658036
116MP0001293_anophthalmia1.09020205
117MP0002085_abnormal_embryonic_tissue1.08659294
118MP0002184_abnormal_innervation1.07904968
119MP0005451_abnormal_body_composition1.07778699
120MP0008007_abnormal_cellular_replicative1.05950834
121MP0004197_abnormal_fetal_growth/weight/1.05661924
122MP0000465_gastrointestinal_hemorrhage1.04388376
123MP0000313_abnormal_cell_death1.04089775
124MP0010630_abnormal_cardiac_muscle1.01726505
125MP0005666_abnormal_adipose_tissue1.00348059
126MP0008775_abnormal_heart_ventricle1.00075824
127MP0005025_abnormal_response_to0.99697426
128MP0005187_abnormal_penis_morphology0.99413964
129MP0010678_abnormal_skin_adnexa0.97778080
130MP0002229_neurodegeneration0.97066481
131MP0004043_abnormal_pH_regulation0.94768376
132MP0002161_abnormal_fertility/fecundity0.94649195
133MP0005248_abnormal_Harderian_gland0.93949037
134MP0001879_abnormal_lymphatic_vessel0.93518788
135MP0002102_abnormal_ear_morphology0.92433318
136MP0000647_abnormal_sebaceous_gland0.92396737
137MP0003303_peritoneal_inflammation0.92258473
138MP0002086_abnormal_extraembryonic_tissu0.90721485
139MP0002080_prenatal_lethality0.88390811
140MP0005084_abnormal_gallbladder_morpholo0.87472052
141MP0003091_abnormal_cell_migration0.87094314
142MP0002233_abnormal_nose_morphology0.86396428
143MP0005670_abnormal_white_adipose0.86352526
144MP0001697_abnormal_embryo_size0.85349519
145MP0002735_abnormal_chemical_nociception0.85121953
146MP0009697_abnormal_copulation0.83582057
147MP0004947_skin_inflammation0.83385699
148MP0003718_maternal_effect0.82770245
149MP0009333_abnormal_splenocyte_physiolog0.82738503
150MP0000733_abnormal_muscle_development0.81714153
151MP0005365_abnormal_bile_salt0.80633760
152MP0003119_abnormal_digestive_system0.79833321
153MP0002069_abnormal_eating/drinking_beha0.79481881
154MP0002092_abnormal_eye_morphology0.79384283
155MP0001849_ear_inflammation0.79376984
156MP0002166_altered_tumor_susceptibility0.79298067
157MP0000049_abnormal_middle_ear0.78970751
158MP0005621_abnormal_cell_physiology0.78634569
159MP0001853_heart_inflammation0.78162135
160MP0003436_decreased_susceptibility_to0.77665706
161MP0003878_abnormal_ear_physiology0.77547854
162MP0005377_hearing/vestibular/ear_phenot0.77547854
163MP0008789_abnormal_olfactory_epithelium0.76748917
164MP0000371_diluted_coat_color0.74253484
165MP0005195_abnormal_posterior_eye0.73403527
166MP0004185_abnormal_adipocyte_glucose0.73202318
167MP0001944_abnormal_pancreas_morphology0.72769331
168MP0003115_abnormal_respiratory_system0.71160795
169MP0002075_abnormal_coat/hair_pigmentati0.71081664
170MP0008961_abnormal_basal_metabolism0.70728995
171MP0002095_abnormal_skin_pigmentation0.70594019
172MP0006072_abnormal_retinal_apoptosis0.70318479
173MP0003950_abnormal_plasma_membrane0.70192923
174MP0000477_abnormal_intestine_morphology0.70062069
175MP0005394_taste/olfaction_phenotype0.67533035
176MP0005499_abnormal_olfactory_system0.67533035
177MP0000566_synostosis0.67307784
178MP0002269_muscular_atrophy0.65734322
179MP0005391_vision/eye_phenotype0.65283429
180MP0009250_abnormal_appendicular_skeleto0.65139866
181MP0005171_absent_coat_pigmentation0.65139465
182MP0009115_abnormal_fat_cell0.62836723
183MP0002752_abnormal_somatic_nervous0.62566334

Predicted human phenotypes

RankGene SetZ-score
1Toxemia of pregnancy (HP:0100603)9.03300421
2Abnormality of pyruvate family amino acid metabolism (HP:0010915)6.83763261
3Abnormality of alanine metabolism (HP:0010916)6.83763261
4Hyperalaninemia (HP:0003348)6.83763261
5Polygenic inheritance (HP:0010982)4.99589593
6Chronic hepatic failure (HP:0100626)4.40502106
7Limb hypertonia (HP:0002509)4.06919320
8Congenital sensorineural hearing impairment (HP:0008527)4.00261682
9Action tremor (HP:0002345)3.84973211
10Ependymoma (HP:0002888)3.79001180
11Chorioretinal atrophy (HP:0000533)3.77029214
12Constricted visual fields (HP:0001133)3.74976799
13Gastrointestinal inflammation (HP:0004386)3.66218972
14Abnormal umbilical cord blood vessels (HP:0011403)3.58113205
15Single umbilical artery (HP:0001195)3.58113205
16Abnormality of the fetal cardiovascular system (HP:0010948)3.58113205
17Esophageal varix (HP:0002040)3.56452307
18Hand muscle atrophy (HP:0009130)3.55207069
19Inflammation of the large intestine (HP:0002037)3.49967788
20Insulin-resistant diabetes mellitus (HP:0000831)3.48414627
21Agammaglobulinemia (HP:0004432)3.29031884
22Tetraparesis (HP:0002273)3.26521742
23Abnormality of the fingertips (HP:0001211)3.17354188
24Pendular nystagmus (HP:0012043)3.16302875
25Myopathic facies (HP:0002058)3.10510167
26Spontaneous hematomas (HP:0007420)3.06009791
27Generalized aminoaciduria (HP:0002909)3.04150628
28Impaired vibration sensation in the lower limbs (HP:0002166)3.02752471
29Birth length less than 3rd percentile (HP:0003561)3.01425613
30Chromsome breakage (HP:0040012)2.95588767
31Abnormality of the lower motor neuron (HP:0002366)2.92878373
32Long clavicles (HP:0000890)2.90828602
33Abnormality of serum amino acid levels (HP:0003112)2.90461310
34Retinal dysplasia (HP:0007973)2.85700113
35Recurrent viral infections (HP:0004429)2.81641443
36Prenatal maternal abnormality (HP:0002686)2.81627724
37IgM deficiency (HP:0002850)2.79996379
38Basal cell carcinoma (HP:0002671)2.78390042
39White forelock (HP:0002211)2.77652926
40Thyroid-stimulating hormone excess (HP:0002925)2.77257119
41Recurrent bronchitis (HP:0002837)2.76825969
42Heterotopia (HP:0002282)2.73251826
43Colitis (HP:0002583)2.71449606
44Astrocytoma (HP:0009592)2.71074552
45Abnormality of the astrocytes (HP:0100707)2.71074552
46Hypoplasia of the capital femoral epiphysis (HP:0003090)2.70361524
47Upper limb muscle weakness (HP:0003484)2.68528540
48Cellulitis (HP:0100658)2.68388420
49Patchy hypopigmentation of hair (HP:0011365)2.66503106
50Dyskinesia (HP:0100660)2.63153088
51T lymphocytopenia (HP:0005403)2.61350447
52Hypoalphalipoproteinemia (HP:0003233)2.56350992
53Upper limb amyotrophy (HP:0009129)2.53528826
54Distal upper limb amyotrophy (HP:0007149)2.53528826
55Proximal tubulopathy (HP:0000114)2.52935181
56Dynein arm defect of respiratory motile cilia (HP:0012255)2.52802891
57Absent/shortened dynein arms (HP:0200106)2.52802891
58Multifactorial inheritance (HP:0001426)2.49933611
59Impulsivity (HP:0100710)2.45213693
60Hyperglycinemia (HP:0002154)2.44220961
61Vertebral arch anomaly (HP:0008438)2.44208901
62Myocardial infarction (HP:0001658)2.42941318
63Nasal polyposis (HP:0100582)2.36734930
64Attenuation of retinal blood vessels (HP:0007843)2.35871441
65Abnormality of sulfur amino acid metabolism (HP:0004339)2.35738083
66Recurrent sinusitis (HP:0011108)2.35182942
67Abnormality of homocysteine metabolism (HP:0010919)2.34118428
68Homocystinuria (HP:0002156)2.34118428
69Increased nuchal translucency (HP:0010880)2.32323244
70Decreased electroretinogram (ERG) amplitude (HP:0000654)2.31393451
71Rhabdomyosarcoma (HP:0002859)2.30267077
72Abnormality of T cell number (HP:0011839)2.29541035
73Anal stenosis (HP:0002025)2.29255817
74Overlapping toe (HP:0001845)2.29255374
75Poikiloderma (HP:0001029)2.26491772
76Ectopic kidney (HP:0000086)2.26332735
77Volvulus (HP:0002580)2.24829994
78Abnormality of the nasal septum (HP:0000419)2.23491362
79Diaphragmatic weakness (HP:0009113)2.21116764
80Neoplasm of striated muscle (HP:0009728)2.20002497
81Upper motor neuron abnormality (HP:0002127)2.18771184
82Neoplasm of the oral cavity (HP:0100649)2.18249768
83Abnormality of the umbilical cord (HP:0010881)2.17553456
84Recurrent otitis media (HP:0000403)2.17394498
85Medulloblastoma (HP:0002885)2.16824493
86Fatigue (HP:0012378)2.15295404
87Abnormal delayed hypersensitivity skin test (HP:0002963)2.14949389
88Pustule (HP:0200039)2.14368245
89Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.12446943
90Absent epiphyses (HP:0010577)2.12446943
91Disproportionate short-trunk short stature (HP:0003521)2.12264955
92Agnosia (HP:0010524)2.12083780
93Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12011908
94Verrucae (HP:0200043)2.11320176
95Papilloma (HP:0012740)2.11320176
96Tubulointerstitial nephritis (HP:0001970)2.09655164
97Portal hypertension (HP:0001409)2.09429891
98Glioma (HP:0009733)2.07930972
99Cone-rod dystrophy (HP:0000548)2.06871037
100Anterior segment dysgenesis (HP:0007700)2.06253183
101Amaurosis fugax (HP:0100576)2.04976246
102Sandal gap (HP:0001852)2.04461479
103Prominent nose (HP:0000448)2.03887643
104Hypopigmentation of the fundus (HP:0007894)2.03810366
105Carpal bone hypoplasia (HP:0001498)2.03582767
106Focal segmental glomerulosclerosis (HP:0000097)2.00016456
107Hyperacusis (HP:0010780)1.99760958
108Bronchitis (HP:0012387)1.99432515
109Limited elbow extension (HP:0001377)1.98822278
110Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.98605700
111Gastrointestinal stroma tumor (HP:0100723)1.96594998
112Ankyloglossia (HP:0010296)1.95334568
113Abolished electroretinogram (ERG) (HP:0000550)1.94903260
114Decreased subcutaneous fat (HP:0001002)1.94822503
115Loss of speech (HP:0002371)1.94716987
116Facial hemangioma (HP:0000329)1.93168142
117Malignant gastrointestinal tract tumors (HP:0006749)1.92915156
118Gastrointestinal carcinoma (HP:0002672)1.92915156
119Chronic otitis media (HP:0000389)1.92089850
120Long foot (HP:0001833)1.90074568
121Small epiphyses (HP:0010585)1.90067053
122Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.89294669
123IgA deficiency (HP:0002720)1.88959872
124Abnormality of the hepatic vasculature (HP:0006707)1.88608542
125Ulnar bowing (HP:0003031)1.87295218
126Abnormality of the labia minora (HP:0012880)1.87131656
127Biliary tract neoplasm (HP:0100574)1.85272722
128Abnormality of T cells (HP:0002843)1.84013860
129Tibial bowing (HP:0002982)1.83530540
130Recurrent fungal infections (HP:0002841)1.82933241
131Cafe-au-lait spot (HP:0000957)1.82119477
132Spastic gait (HP:0002064)1.78772173
133Tented upper lip vermilion (HP:0010804)1.78579595
134Macroorchidism (HP:0000053)1.78341006
135Depressed nasal tip (HP:0000437)1.77549598
136Meningitis (HP:0001287)1.77232441
137Anencephaly (HP:0002323)1.76131834
138Pseudobulbar signs (HP:0002200)1.75996225
139Premature loss of primary teeth (HP:0006323)1.75766388
140Oligodontia (HP:0000677)1.75600185
141Short ribs (HP:0000773)1.75482410
142Pancreatic cysts (HP:0001737)1.74876595
143Renovascular hypertension (HP:0100817)1.74795631
144Thin bony cortex (HP:0002753)1.74784572
145Intestinal fistula (HP:0100819)1.73897875
146Bronchiectasis (HP:0002110)1.73821411
147Myelodysplasia (HP:0002863)1.73749923
148Increased corneal curvature (HP:0100692)1.71323980
149Keratoconus (HP:0000563)1.71323980
150Selective tooth agenesis (HP:0001592)1.70850268
151Low anterior hairline (HP:0000294)1.69722723
152Emphysema (HP:0002097)1.69002718
153Lip pit (HP:0100267)1.67768528
154Abnormality of the phalanges of the hallux (HP:0010057)1.66191080
155Ureteral stenosis (HP:0000071)1.66099092
156Glomerulosclerosis (HP:0000096)1.65791520
157Cutis marmorata (HP:0000965)1.65140572
158Abnormality of cells of the lymphoid lineage (HP:0012140)1.65091676
159Progressive cerebellar ataxia (HP:0002073)1.64810727
160Muscular hypotonia of the trunk (HP:0008936)1.63992470
161Long eyelashes (HP:0000527)1.62943097
162Lymphopenia (HP:0001888)1.62881006
163Large eyes (HP:0001090)1.62223749
164Panhypogammaglobulinemia (HP:0003139)1.61747535
165Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.61413107
166Abnormality of DNA repair (HP:0003254)1.61412661
167Conjunctival telangiectasia (HP:0000524)1.60896990
168Lower limb muscle weakness (HP:0007340)1.60765982
169Nephronophthisis (HP:0000090)1.60382990
170Conjugated hyperbilirubinemia (HP:0002908)1.60317232
171Abnormality of the diencephalon (HP:0010662)1.59951493
172Abnormality of the gastric mucosa (HP:0004295)1.59067661
173Heterochromia iridis (HP:0001100)1.59014199
174Colon cancer (HP:0003003)1.58939967
175Abnormality of the epiphyses of the hand (HP:0005924)1.58723535
176Fibular hypoplasia (HP:0003038)1.58654638
177Rhinitis (HP:0012384)1.58476051
178Chronic sinusitis (HP:0011109)1.58171403
179Supernumerary spleens (HP:0009799)1.58044876
180Epidermoid cyst (HP:0200040)1.57559210
181Clonus (HP:0002169)1.57380555
182True hermaphroditism (HP:0010459)1.56616099
183Short 1st metacarpal (HP:0010034)1.56029041
184Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.56029041
185Maternal diabetes (HP:0009800)1.55479082
186Impaired vibratory sensation (HP:0002495)1.54849365
187Pancreatic fibrosis (HP:0100732)1.53702493
188Abnormality of the renal cortex (HP:0011035)1.53159169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.66390682
2CDK123.96257730
3PHKG23.24054736
4PHKG13.24054736
5MAP3K102.95280081
6EEF2K2.95199124
7BRD42.86082125
8MAP4K12.80542967
9NEK22.70709670
10NTRK22.60039525
11STK242.51476456
12MAP3K32.39605572
13ICK2.26379439
14MARK12.22626517
15CCNB12.14656328
16MAP2K32.07765496
17PDK42.05180551
18PDK32.05180551
19TAF11.96258400
20SGK2231.95413921
21SGK4941.95413921
22PKN21.94613922
23MAP4K21.94602610
24CDC71.73509278
25PRKD21.69603825
26TXK1.65533620
27NEK61.61396431
28STK101.59407574
29TRIB31.59065105
30FGFR21.57027933
31STK31.57019698
32FRK1.55826385
33STK38L1.55027106
34PIK3CA1.52503847
35ACVR1B1.52175290
36PTK61.49201527
37PNCK1.48041619
38TTK1.46931815
39IRAK31.45858907
40ERBB21.44948314
41JAK31.44508834
42TTN1.40983766
43ALK1.40200574
44STK41.38448964
45RPS6KB21.38293786
46STK391.36697579
47FER1.34526352
48PRKCE1.33917445
49GRK61.33525298
50SGK21.30306722
51PASK1.23630053
52FGFR31.20402221
53TSSK61.16131685
54BTK1.14110455
55CDK41.13040566
56PRKCH1.12368176
57TAOK31.12346510
58PINK11.10915948
59PRKAA21.08445881
60CDK91.07377232
61CHUK1.06691417
62FGR1.06062519
63EPHB11.04646201
64MTOR1.03673787
65BRSK21.02652015
66JAK11.02599817
67TYK21.01584801
68PIM11.00251812
69EIF2AK31.00128840
70ATR0.97518545
71IKBKB0.97345372
72FGFR40.97177408
73CHEK20.96227717
74CHEK10.95336364
75MAP3K130.94785430
76CSF1R0.94051150
77ERBB30.93831302
78CDK60.93471426
79CDK70.91620348
80HCK0.91014453
81EPHA30.88545960
82ZAK0.88239693
83NTRK30.88118576
84MELK0.86907714
85ITK0.86856043
86ATM0.84700170
87ADRBK10.83473916
88MAP3K40.81283558
89PLK20.80803427
90SIK20.80442040
91BLK0.79628991
92ADRBK20.79387179
93GRK10.78564382
94RPS6KA40.78295972
95MAPK130.78119933
96MAP3K140.77977456
97DYRK30.75923449
98LCK0.75143547
99LMTK20.74570434
100ERN10.73524005
101PLK10.72655775
102AURKB0.71815664
103CAMK1D0.71451890
104MAP3K80.71097570
105ZAP700.70006897
106WNK10.69926646
107ABL20.68234701
108CSNK1D0.67673215
109SYK0.67112062
110CDK20.66024948
111AKT20.65751595
112EPHA20.65419055
113PDK20.64066266
114MAP2K70.63959186
115TRIM280.63881909
116INSRR0.63450119
117WNK40.63427718
118TIE10.62031330
119TRPM70.61821157
120TYRO30.60008839
121WNK30.59546696
122SIK10.58934225
123PDK10.58857980
124PAK40.58793111
125NEK10.58421333
126JAK20.58147524
127CAMK1G0.58131004
128ROCK10.56791306
129PLK40.56720977
130LATS10.55857998
131PAK20.55735712
132SGK30.55072795
133PRKAA10.52018364
134LYN0.50810759
135DYRK1B0.49083163
136PRKD30.48895703
137DYRK20.48270534
138STK380.47890592
139PRKCQ0.47362982
140SRPK10.46761447
141CSNK1A10.46684331
142PKN10.46203064
143CDK10.45842670
144RPS6KB10.45446638
145TEC0.45294042
146PRKG20.45112965
147AKT10.44023527
148RPS6KA50.43918937
149CAMK10.42286817
150DMPK0.41623323
151ABL10.41325502
152IGF1R0.41302820
153INSR0.41264299
154AURKA0.41221680
155LRRK20.40775402
156MAP2K10.40729243
157PAK30.40693479
158AKT30.39057905
159WEE10.38329618
160PDGFRA0.38260552
161ROCK20.35442408
162RPS6KA10.35368208
163NUAK10.34001205
164YES10.33712671
165CAMK2D0.30783013
166PRKCG0.29812723
167OBSCN0.29378364
168RET0.29123667
169PDGFRB0.27860045
170BCR0.26872473
171DAPK20.26126277

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.15210245
2Glycine, serine and threonine metabolism_Homo sapiens_hsa002603.14918248
3B cell receptor signaling pathway_Homo sapiens_hsa046622.77298480
4Sulfur metabolism_Homo sapiens_hsa009202.72753137
5Collecting duct acid secretion_Homo sapiens_hsa049662.65387305
6Primary immunodeficiency_Homo sapiens_hsa053402.63212115
7Arginine biosynthesis_Homo sapiens_hsa002202.61916894
8GABAergic synapse_Homo sapiens_hsa047272.48623955
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43706737
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.40329955
11One carbon pool by folate_Homo sapiens_hsa006702.33650489
12Non-homologous end-joining_Homo sapiens_hsa034502.32520792
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.18917013
14Cysteine and methionine metabolism_Homo sapiens_hsa002702.18910401
15Base excision repair_Homo sapiens_hsa034102.09397198
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.06426715
17Nicotine addiction_Homo sapiens_hsa050332.05173104
18NF-kappa B signaling pathway_Homo sapiens_hsa040642.03341001
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.99128120
20Morphine addiction_Homo sapiens_hsa050321.97618132
21Mismatch repair_Homo sapiens_hsa034301.83687687
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74794037
23Systemic lupus erythematosus_Homo sapiens_hsa053221.69594087
24T cell receptor signaling pathway_Homo sapiens_hsa046601.67997324
25Fanconi anemia pathway_Homo sapiens_hsa034601.67872952
26mRNA surveillance pathway_Homo sapiens_hsa030151.66075905
27Propanoate metabolism_Homo sapiens_hsa006401.61784131
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.61359058
29RNA transport_Homo sapiens_hsa030131.60177212
30Antigen processing and presentation_Homo sapiens_hsa046121.57449431
31Lysine degradation_Homo sapiens_hsa003101.53967407
32Measles_Homo sapiens_hsa051621.51281611
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.47044349
34Viral carcinogenesis_Homo sapiens_hsa052031.43057154
35Selenocompound metabolism_Homo sapiens_hsa004501.42153043
36DNA replication_Homo sapiens_hsa030301.39026519
37Dorso-ventral axis formation_Homo sapiens_hsa043201.38456105
38p53 signaling pathway_Homo sapiens_hsa041151.37047247
39HTLV-I infection_Homo sapiens_hsa051661.36612165
40Cell cycle_Homo sapiens_hsa041101.36398748
41Homologous recombination_Homo sapiens_hsa034401.34430422
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32855622
43Herpes simplex infection_Homo sapiens_hsa051681.32815146
44Small cell lung cancer_Homo sapiens_hsa052221.32669292
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30686527
46Osteoclast differentiation_Homo sapiens_hsa043801.28472028
47Butanoate metabolism_Homo sapiens_hsa006501.27999912
48RNA degradation_Homo sapiens_hsa030181.27732903
49Vitamin digestion and absorption_Homo sapiens_hsa049771.26941037
50Vibrio cholerae infection_Homo sapiens_hsa051101.26274581
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25247120
52Chronic myeloid leukemia_Homo sapiens_hsa052201.24244227
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.24003353
54Spliceosome_Homo sapiens_hsa030401.23516057
55Arginine and proline metabolism_Homo sapiens_hsa003301.23472627
56MicroRNAs in cancer_Homo sapiens_hsa052061.19571783
57Hematopoietic cell lineage_Homo sapiens_hsa046401.18132727
58Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17784392
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16160943
60Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14971854
61Viral myocarditis_Homo sapiens_hsa054161.14854254
62Basal cell carcinoma_Homo sapiens_hsa052171.14070952
63Notch signaling pathway_Homo sapiens_hsa043301.13240870
64Glycerolipid metabolism_Homo sapiens_hsa005611.12360497
65Epstein-Barr virus infection_Homo sapiens_hsa051691.11571456
66Axon guidance_Homo sapiens_hsa043601.10703054
67Jak-STAT signaling pathway_Homo sapiens_hsa046301.10370581
68Alcoholism_Homo sapiens_hsa050341.10085189
69Retinol metabolism_Homo sapiens_hsa008301.09779440
70Pyruvate metabolism_Homo sapiens_hsa006201.08198613
71Toxoplasmosis_Homo sapiens_hsa051451.08000194
72Acute myeloid leukemia_Homo sapiens_hsa052211.07939129
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06486586
74mTOR signaling pathway_Homo sapiens_hsa041501.01945572
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00687922
76Regulation of autophagy_Homo sapiens_hsa041400.98848519
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98421039
78Nitrogen metabolism_Homo sapiens_hsa009100.97673713
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97563358
80Synaptic vesicle cycle_Homo sapiens_hsa047210.97504953
81Pancreatic cancer_Homo sapiens_hsa052120.96341440
82Olfactory transduction_Homo sapiens_hsa047400.95300383
83Leishmaniasis_Homo sapiens_hsa051400.94187993
84Non-small cell lung cancer_Homo sapiens_hsa052230.93786951
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93043685
86Apoptosis_Homo sapiens_hsa042100.92664090
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92469962
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92357069
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91892019
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88741293
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88498006
92Influenza A_Homo sapiens_hsa051640.87076948
93Galactose metabolism_Homo sapiens_hsa000520.86823621
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86403079
95Glutamatergic synapse_Homo sapiens_hsa047240.86190658
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85845273
97Biosynthesis of amino acids_Homo sapiens_hsa012300.85761995
98Peroxisome_Homo sapiens_hsa041460.84308783
99Taste transduction_Homo sapiens_hsa047420.81709147
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81411582
101Serotonergic synapse_Homo sapiens_hsa047260.80867612
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.79104077
103Basal transcription factors_Homo sapiens_hsa030220.77013539
104Colorectal cancer_Homo sapiens_hsa052100.75890305
105Prolactin signaling pathway_Homo sapiens_hsa049170.74608757
106Dopaminergic synapse_Homo sapiens_hsa047280.74593684
107Hepatitis B_Homo sapiens_hsa051610.73579372
108Steroid biosynthesis_Homo sapiens_hsa001000.71017510
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68395700
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.67684927
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67164452
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66600828
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66420239
114Prostate cancer_Homo sapiens_hsa052150.66013976
115Pathways in cancer_Homo sapiens_hsa052000.65085343
116Cholinergic synapse_Homo sapiens_hsa047250.64666491
117Circadian entrainment_Homo sapiens_hsa047130.64437530
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63833268
119Proteoglycans in cancer_Homo sapiens_hsa052050.63750052
120ABC transporters_Homo sapiens_hsa020100.63536696
121Insulin resistance_Homo sapiens_hsa049310.62582840
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62011981
123Inositol phosphate metabolism_Homo sapiens_hsa005620.61285707
124Folate biosynthesis_Homo sapiens_hsa007900.61235827
125PPAR signaling pathway_Homo sapiens_hsa033200.60877674
126Platelet activation_Homo sapiens_hsa046110.60604926
127Adherens junction_Homo sapiens_hsa045200.59921777
128Nucleotide excision repair_Homo sapiens_hsa034200.59541705
129Legionellosis_Homo sapiens_hsa051340.59406129
130RNA polymerase_Homo sapiens_hsa030200.58394104
131Tryptophan metabolism_Homo sapiens_hsa003800.57343037
132Fatty acid biosynthesis_Homo sapiens_hsa000610.56950579
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56848431
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.56239898
135Ribosome_Homo sapiens_hsa030100.56214814
136Endometrial cancer_Homo sapiens_hsa052130.55786007
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55781026
138Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55343750
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54568359
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.53433272
141FoxO signaling pathway_Homo sapiens_hsa040680.52481981
142Pentose phosphate pathway_Homo sapiens_hsa000300.51917002
143VEGF signaling pathway_Homo sapiens_hsa043700.51864471
144Chemokine signaling pathway_Homo sapiens_hsa040620.51558086
145Glucagon signaling pathway_Homo sapiens_hsa049220.51405218
146Ether lipid metabolism_Homo sapiens_hsa005650.51321457
147TNF signaling pathway_Homo sapiens_hsa046680.50546444
148HIF-1 signaling pathway_Homo sapiens_hsa040660.50180367
149Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50053360
150AMPK signaling pathway_Homo sapiens_hsa041520.49944371
151Renal cell carcinoma_Homo sapiens_hsa052110.49895366
152Caffeine metabolism_Homo sapiens_hsa002320.49339812
153Hedgehog signaling pathway_Homo sapiens_hsa043400.47884464
154Wnt signaling pathway_Homo sapiens_hsa043100.47497283
155Phospholipase D signaling pathway_Homo sapiens_hsa040720.45244595
156Metabolic pathways_Homo sapiens_hsa011000.44527404
157Linoleic acid metabolism_Homo sapiens_hsa005910.43568055
158Hepatitis C_Homo sapiens_hsa051600.43086633
159Rheumatoid arthritis_Homo sapiens_hsa053230.42535257
160Sphingolipid metabolism_Homo sapiens_hsa006000.41962515
161Primary bile acid biosynthesis_Homo sapiens_hsa001200.39031891
162Purine metabolism_Homo sapiens_hsa002300.36567096
163Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33497909
164Hippo signaling pathway_Homo sapiens_hsa043900.29661919
165ErbB signaling pathway_Homo sapiens_hsa040120.24662536
166PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24455112
167Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23505420
168Tight junction_Homo sapiens_hsa045300.22444729
169Ras signaling pathway_Homo sapiens_hsa040140.19547699
170Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19260855
171Steroid hormone biosynthesis_Homo sapiens_hsa001400.18493020
172Mineral absorption_Homo sapiens_hsa049780.18018972
173TGF-beta signaling pathway_Homo sapiens_hsa043500.16939343
174Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15329150

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