ZSCAN31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing multiple C2H2-type zinc finger motifs. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.01849184
2intraciliary transport (GO:0042073)3.83893995
3epithelial cilium movement (GO:0003351)3.83353191
4protein localization to cilium (GO:0061512)3.76467139
5cilium movement (GO:0003341)3.72058643
6axonemal dynein complex assembly (GO:0070286)3.47757480
7cilium or flagellum-dependent cell motility (GO:0001539)3.38646540
8histone H2A acetylation (GO:0043968)3.33835773
9nonmotile primary cilium assembly (GO:0035058)3.20370471
10respiratory chain complex IV assembly (GO:0008535)3.13738461
11piRNA metabolic process (GO:0034587)3.12962808
12cilium organization (GO:0044782)3.09513692
13rRNA methylation (GO:0031167)3.08605480
14cilium assembly (GO:0042384)3.03439141
15cellular ketone body metabolic process (GO:0046950)3.01589707
16photoreceptor cell maintenance (GO:0045494)3.01546760
17axoneme assembly (GO:0035082)2.99790768
18righting reflex (GO:0060013)2.99248219
19protein prenylation (GO:0018342)2.95256425
20prenylation (GO:0097354)2.95256425
21daunorubicin metabolic process (GO:0044597)2.92339140
22polyketide metabolic process (GO:0030638)2.92339140
23doxorubicin metabolic process (GO:0044598)2.92339140
24water-soluble vitamin biosynthetic process (GO:0042364)2.92149743
25rRNA modification (GO:0000154)2.90846730
26detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83044890
27L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81220941
28cytochrome complex assembly (GO:0017004)2.79801506
29aminoglycoside antibiotic metabolic process (GO:0030647)2.72417090
30inner ear receptor stereocilium organization (GO:0060122)2.67118030
31auditory receptor cell stereocilium organization (GO:0060088)2.66628979
32ketone body metabolic process (GO:1902224)2.66551955
33retinal metabolic process (GO:0042574)2.65017672
34amino acid salvage (GO:0043102)2.64736972
35L-methionine salvage (GO:0071267)2.64736972
36L-methionine biosynthetic process (GO:0071265)2.64736972
37endocrine pancreas development (GO:0031018)2.63294029
38protein complex biogenesis (GO:0070271)2.61612296
39regulation of cilium movement (GO:0003352)2.58654193
40mitochondrial respiratory chain complex assembly (GO:0033108)2.58029672
41detection of light stimulus involved in sensory perception (GO:0050962)2.57266711
42detection of light stimulus involved in visual perception (GO:0050908)2.57266711
43nephron tubule morphogenesis (GO:0072078)2.55108214
44nephron epithelium morphogenesis (GO:0072088)2.55108214
45cilium morphogenesis (GO:0060271)2.51194391
46S-adenosylmethionine metabolic process (GO:0046500)2.45979658
47lactate metabolic process (GO:0006089)2.45366636
48regulation of meiosis I (GO:0060631)2.43798528
49pyrimidine dimer repair (GO:0006290)2.42334562
50reflex (GO:0060004)2.42205259
51DNA methylation involved in gamete generation (GO:0043046)2.39369606
52positive regulation of mitochondrial fission (GO:0090141)2.39336011
53cellular component assembly involved in morphogenesis (GO:0010927)2.38999086
54centriole replication (GO:0007099)2.37725233
55cullin deneddylation (GO:0010388)2.37192980
56regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.37095572
57regulation of mitotic spindle checkpoint (GO:1903504)2.37095572
583-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.36852121
59purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.36852121
60terpenoid biosynthetic process (GO:0016114)2.36681323
61regulation of hexokinase activity (GO:1903299)2.36233562
62regulation of glucokinase activity (GO:0033131)2.36233562
63erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.36200492
64L-phenylalanine catabolic process (GO:0006559)2.36200492
65mechanosensory behavior (GO:0007638)2.33767682
66peptidyl-histidine modification (GO:0018202)2.32819609
67resolution of meiotic recombination intermediates (GO:0000712)2.30539512
68somatic diversification of immune receptors via somatic mutation (GO:0002566)2.28688870
69somatic hypermutation of immunoglobulin genes (GO:0016446)2.28688870
70branched-chain amino acid catabolic process (GO:0009083)2.28614621
71reciprocal DNA recombination (GO:0035825)2.25128395
72reciprocal meiotic recombination (GO:0007131)2.25128395
73retinol metabolic process (GO:0042572)2.25025027
74dopamine transport (GO:0015872)2.20042081
75auditory behavior (GO:0031223)2.19694074
76ubiquinone biosynthetic process (GO:0006744)2.18874303
77ubiquinone metabolic process (GO:0006743)2.18463556
78peroxisome fission (GO:0016559)2.15034985
79L-phenylalanine metabolic process (GO:0006558)2.14849292
80erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.14849292
81establishment of protein localization to mitochondrial membrane (GO:0090151)2.14776842
82insulin secretion (GO:0030073)2.14627513
83motile cilium assembly (GO:0044458)2.13676545
84quinone metabolic process (GO:1901661)2.13330013
85synapsis (GO:0007129)2.12097619
86smoothened signaling pathway (GO:0007224)2.10990489
87cornea development in camera-type eye (GO:0061303)2.09638913
88lipid particle organization (GO:0034389)2.09248433
89regulation of centrosome duplication (GO:0010824)2.09082624
90auditory receptor cell differentiation (GO:0042491)2.08444820
91methionine biosynthetic process (GO:0009086)2.08215859
92glutathione derivative metabolic process (GO:1901685)2.07835847
93glutathione derivative biosynthetic process (GO:1901687)2.07835847
94succinate metabolic process (GO:0006105)2.06762726
95mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.05555252
96neural tube formation (GO:0001841)2.05107139
97photoreceptor cell differentiation (GO:0046530)2.04321366
98eye photoreceptor cell differentiation (GO:0001754)2.04321366
99left/right axis specification (GO:0070986)2.04245729
100spermatid development (GO:0007286)2.01595168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.24971453
2ZNF274_21170338_ChIP-Seq_K562_Hela3.29757625
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.90732194
4VDR_22108803_ChIP-Seq_LS180_Human2.85296542
5GBX2_23144817_ChIP-Seq_PC3_Human2.83944631
6TAF15_26573619_Chip-Seq_HEK293_Human2.68471096
7FUS_26573619_Chip-Seq_HEK293_Human2.55386330
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.55175794
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41829077
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35291941
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20337749
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13731982
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.09036645
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06182255
15EWS_26573619_Chip-Seq_HEK293_Human1.98320086
16GABP_17652178_ChIP-ChIP_JURKAT_Human1.95987552
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.92917323
18IGF1R_20145208_ChIP-Seq_DFB_Human1.91774292
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88050863
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86911871
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.81882432
22P300_19829295_ChIP-Seq_ESCs_Human1.81765713
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77837984
24SMAD4_21799915_ChIP-Seq_A2780_Human1.74660073
25ELK1_19687146_ChIP-ChIP_HELA_Human1.73105663
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.67666498
27ER_23166858_ChIP-Seq_MCF-7_Human1.64225831
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.60196915
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.60160829
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55948292
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55280534
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54341786
33RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.51654455
34FOXM1_26456572_ChIP-Seq_MCF-7_Human1.48537789
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48218570
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44556558
37AR_25329375_ChIP-Seq_VCAP_Human1.40966639
38STAT3_23295773_ChIP-Seq_U87_Human1.39456048
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38788312
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35336084
41CBP_20019798_ChIP-Seq_JUKART_Human1.35336084
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34435921
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33037808
44MYC_18940864_ChIP-ChIP_HL60_Human1.31559631
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31000369
46TCF4_23295773_ChIP-Seq_U87_Human1.29394078
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28276251
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27970716
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26533010
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26473462
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26236840
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24556826
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24262935
54IRF1_19129219_ChIP-ChIP_H3396_Human1.23741899
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21461370
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21376091
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.21310424
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16977428
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.16580763
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16046303
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15488799
62RNF2_27304074_Chip-Seq_NSC_Mouse1.13903716
63BCAT_22108803_ChIP-Seq_LS180_Human1.12448248
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.12362254
65NANOG_19829295_ChIP-Seq_ESCs_Human1.12232882
66SOX2_19829295_ChIP-Seq_ESCs_Human1.12232882
67TP53_22573176_ChIP-Seq_HFKS_Human1.12156225
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11744335
69TCF4_22108803_ChIP-Seq_LS180_Human1.10363276
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09112568
71TAL1_26923725_Chip-Seq_HPCs_Mouse1.08010337
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07473032
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.07195326
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06983272
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.06838988
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06725007
77RUNX2_22187159_ChIP-Seq_PCA_Human1.06589772
78E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06545391
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06107707
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05302784
81PHF8_20622853_ChIP-Seq_HELA_Human1.05100830
82VDR_23849224_ChIP-Seq_CD4+_Human1.03801109
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02819313
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02819313
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02634905
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00698488
87CDX2_22108803_ChIP-Seq_LS180_Human1.00269376
88FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00181832
89FOXA1_25329375_ChIP-Seq_VCAP_Human1.00181832
90CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99879356
91P53_22387025_ChIP-Seq_ESCs_Mouse0.99423906
92E2F1_18555785_Chip-Seq_ESCs_Mouse0.96966442
93ETV1_20927104_ChIP-Seq_GIST48_Human0.96541648
94AR_20517297_ChIP-Seq_VCAP_Human0.95252201
95NFE2_27457419_Chip-Seq_LIVER_Mouse0.95120929
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94922982
97SMAD4_21741376_ChIP-Seq_EPCs_Human0.94793338
98SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93934609
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93381518
100ETS1_20019798_ChIP-Seq_JURKAT_Human0.93105722

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.65383561
2MP0009780_abnormal_chondrocyte_physiolo2.51541180
3MP0002837_dystrophic_cardiac_calcinosis2.19641295
4MP0005646_abnormal_pituitary_gland2.08866827
5MP0004147_increased_porphyrin_level2.05595586
6MP0002938_white_spotting1.96182364
7MP0008875_abnormal_xenobiotic_pharmacok1.93054374
8MP0008058_abnormal_DNA_repair1.89866571
9MP0005084_abnormal_gallbladder_morpholo1.89814130
10MP0003880_abnormal_central_pattern1.89060059
11MP0003718_maternal_effect1.88882909
12MP0009046_muscle_twitch1.88400856
13MP0002139_abnormal_hepatobiliary_system1.81084650
14MP0000566_synostosis1.76580739
15MP0006072_abnormal_retinal_apoptosis1.75757729
16MP0003195_calcinosis1.75348301
17MP0005551_abnormal_eye_electrophysiolog1.70816147
18MP0004043_abnormal_pH_regulation1.66660377
19MP0000631_abnormal_neuroendocrine_gland1.66104831
20MP0002638_abnormal_pupillary_reflex1.64285213
21MP0001984_abnormal_olfaction1.64041396
22MP0003787_abnormal_imprinting1.59178239
23MP0000372_irregular_coat_pigmentation1.56407680
24MP0005085_abnormal_gallbladder_physiolo1.54129779
25MP0001529_abnormal_vocalization1.51341976
26MP0003122_maternal_imprinting1.49880045
27MP0004133_heterotaxia1.43230493
28MP0005253_abnormal_eye_physiology1.41116498
29MP0001986_abnormal_taste_sensitivity1.40420514
30MP0005083_abnormal_biliary_tract1.38978749
31MP0005187_abnormal_penis_morphology1.33050834
32MP0006276_abnormal_autonomic_nervous1.32568609
33MP0001486_abnormal_startle_reflex1.31483712
34MP0005365_abnormal_bile_salt1.30248211
35MP0008057_abnormal_DNA_replication1.28418277
36MP0005423_abnormal_somatic_nervous1.27973799
37MP0002102_abnormal_ear_morphology1.26080346
38MP0001944_abnormal_pancreas_morphology1.25309405
39MP0004885_abnormal_endolymph1.24681753
40MP0008789_abnormal_olfactory_epithelium1.24659171
41MP0006036_abnormal_mitochondrial_physio1.24641681
42MP0004145_abnormal_muscle_electrophysio1.23195228
43MP0000383_abnormal_hair_follicle1.20407518
44MP0000647_abnormal_sebaceous_gland1.19899239
45MP0003937_abnormal_limbs/digits/tail_de1.19796085
46MP0002272_abnormal_nervous_system1.19412017
47MP0004215_abnormal_myocardial_fiber1.18052839
48MP0003950_abnormal_plasma_membrane1.17395846
49MP0006035_abnormal_mitochondrial_morpho1.17221992
50MP0002876_abnormal_thyroid_physiology1.16812580
51MP0010678_abnormal_skin_adnexa1.16186122
52MP0001501_abnormal_sleep_pattern1.14685245
53MP0009745_abnormal_behavioral_response1.13896315
54MP0010386_abnormal_urinary_bladder1.11580667
55MP0003786_premature_aging1.11454508
56MP0003137_abnormal_impulse_conducting1.11422471
57MP0004019_abnormal_vitamin_homeostasis1.09720537
58MP0002160_abnormal_reproductive_system1.07048286
59MP0005332_abnormal_amino_acid1.06934919
60MP0001764_abnormal_homeostasis1.04769108
61MP0000013_abnormal_adipose_tissue1.04658381
62MP0003252_abnormal_bile_duct1.01755232
63MP0001502_abnormal_circadian_rhythm0.98883515
64MP0005395_other_phenotype0.98505925
65MP0002928_abnormal_bile_duct0.98050477
66MP0005220_abnormal_exocrine_pancreas0.97644646
67MP0002693_abnormal_pancreas_physiology0.96932142
68MP0003186_abnormal_redox_activity0.96220696
69MP0001929_abnormal_gametogenesis0.95291865
70MP0002233_abnormal_nose_morphology0.95120045
71MP0002234_abnormal_pharynx_morphology0.94728042
72MP0004085_abnormal_heartbeat0.94653437
73MP0000427_abnormal_hair_cycle0.93846197
74MP0003011_delayed_dark_adaptation0.93785272
75MP0004270_analgesia0.93590537
76MP0008961_abnormal_basal_metabolism0.93376234
77MP0002909_abnormal_adrenal_gland0.92803878
78MP0002653_abnormal_ependyma_morphology0.90714806
79MP0008872_abnormal_physiological_respon0.90678386
80MP0003121_genomic_imprinting0.87637248
81MP0001485_abnormal_pinna_reflex0.87503283
82MP0003698_abnormal_male_reproductive0.86873027
83MP0005386_behavior/neurological_phenoty0.86345983
84MP0004924_abnormal_behavior0.86345983
85MP0001905_abnormal_dopamine_level0.86008198
86MP0005410_abnormal_fertilization0.85834275
87MP0006292_abnormal_olfactory_placode0.84434339
88MP0003868_abnormal_feces_composition0.84078901
89MP0002572_abnormal_emotion/affect_behav0.83977910
90MP0008995_early_reproductive_senescence0.83794221
91MP0005499_abnormal_olfactory_system0.83126991
92MP0005394_taste/olfaction_phenotype0.83126991
93MP0002557_abnormal_social/conspecific_i0.80701895
94MP0009697_abnormal_copulation0.79953852
95MP0000653_abnormal_sex_gland0.78704954
96MP0005645_abnormal_hypothalamus_physiol0.78466214
97MP0005636_abnormal_mineral_homeostasis0.78455798
98MP0002822_catalepsy0.78117841
99MP0004142_abnormal_muscle_tone0.77899267
100MP0010329_abnormal_lipoprotein_level0.77581396

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)3.68964652
2Pancreatic cysts (HP:0001737)3.64054558
3True hermaphroditism (HP:0010459)3.60096563
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.57799813
5Pancreatic fibrosis (HP:0100732)3.43509462
6Gait imbalance (HP:0002141)3.38413864
7Congenital primary aphakia (HP:0007707)3.26743906
8Nephronophthisis (HP:0000090)3.24439960
9Abnormal respiratory motile cilium physiology (HP:0012261)3.12264891
10Rhinitis (HP:0012384)3.06447440
11Abnormality of midbrain morphology (HP:0002418)3.05174863
12Molar tooth sign on MRI (HP:0002419)3.05174863
13Abnormal respiratory epithelium morphology (HP:0012253)2.95947941
14Abnormal respiratory motile cilium morphology (HP:0005938)2.95947941
15Abnormal ciliary motility (HP:0012262)2.94432013
16Nephrogenic diabetes insipidus (HP:0009806)2.83112067
17Abnormality of the renal medulla (HP:0100957)2.68435543
18Chronic hepatic failure (HP:0100626)2.63464326
19Hyperventilation (HP:0002883)2.61344453
20Ketoacidosis (HP:0001993)2.50516685
21Genital tract atresia (HP:0001827)2.48260826
22Tubulointerstitial nephritis (HP:0001970)2.46851750
23Abnormality of the renal cortex (HP:0011035)2.45601677
24Hypothermia (HP:0002045)2.43488711
25Absent/shortened dynein arms (HP:0200106)2.40992915
26Dynein arm defect of respiratory motile cilia (HP:0012255)2.40992915
27Vaginal atresia (HP:0000148)2.39501987
28Acute necrotizing encephalopathy (HP:0006965)2.39217452
29Acute encephalopathy (HP:0006846)2.36435314
30Progressive inability to walk (HP:0002505)2.32429416
31Hepatic necrosis (HP:0002605)2.31763978
32Methylmalonic aciduria (HP:0012120)2.27812821
33Type II lissencephaly (HP:0007260)2.27736854
34Poor coordination (HP:0002370)2.25634827
35Methylmalonic acidemia (HP:0002912)2.24169297
36Intestinal atresia (HP:0011100)2.23433455
37Atonic seizures (HP:0010819)2.22609016
38Chronic bronchitis (HP:0004469)2.21576203
39Cystic liver disease (HP:0006706)2.20780362
40Abnormality of the pancreatic islet cells (HP:0006476)2.18648540
41Abnormality of endocrine pancreas physiology (HP:0012093)2.18648540
42Progressive macrocephaly (HP:0004481)2.18159104
43Aplasia/Hypoplasia of the tongue (HP:0010295)2.16767003
44Abnormal mitochondria in muscle tissue (HP:0008316)2.14138457
45Mitochondrial inheritance (HP:0001427)2.11268764
46Male pseudohermaphroditism (HP:0000037)2.07010266
47Tubular atrophy (HP:0000092)2.06362736
48Increased CSF lactate (HP:0002490)2.06212022
49Degeneration of the lateral corticospinal tracts (HP:0002314)2.00998996
50Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.00998996
51Congenital hepatic fibrosis (HP:0002612)1.97729434
52Anencephaly (HP:0002323)1.97605848
53Postaxial hand polydactyly (HP:0001162)1.95942310
54Ependymoma (HP:0002888)1.95629281
55Congenital stationary night blindness (HP:0007642)1.95246086
56Volvulus (HP:0002580)1.95171937
57Postaxial foot polydactyly (HP:0001830)1.95026182
58Abnormality of the labia minora (HP:0012880)1.94732452
59Febrile seizures (HP:0002373)1.91390654
60Renal cortical cysts (HP:0000803)1.90826913
61Cerebellar dysplasia (HP:0007033)1.90630658
62Vascular calcification (HP:0004934)1.89626523
63Hepatocellular necrosis (HP:0001404)1.89102821
64Aplasia/Hypoplasia of the tibia (HP:0005772)1.88430344
65Gaze-evoked nystagmus (HP:0000640)1.85569305
66Abnormal rod and cone electroretinograms (HP:0008323)1.84827061
67Biliary tract neoplasm (HP:0100574)1.84066253
68Increased hepatocellular lipid droplets (HP:0006565)1.82794996
69Furrowed tongue (HP:0000221)1.82379347
70Lipid accumulation in hepatocytes (HP:0006561)1.82097032
71Hyperglycinemia (HP:0002154)1.81212567
72Occipital encephalocele (HP:0002085)1.80382989
73Attenuation of retinal blood vessels (HP:0007843)1.80080586
74Bile duct proliferation (HP:0001408)1.78643789
75Abnormal biliary tract physiology (HP:0012439)1.78643789
76Astrocytoma (HP:0009592)1.77781261
77Abnormality of the astrocytes (HP:0100707)1.77781261
78Sclerocornea (HP:0000647)1.77712048
79Short tibia (HP:0005736)1.77620522
80Large for gestational age (HP:0001520)1.75901803
81Abnormality of aromatic amino acid family metabolism (HP:0004338)1.73766833
82Hypoglycemic coma (HP:0001325)1.72035866
83Preaxial hand polydactyly (HP:0001177)1.70590821
84Aplasia/Hypoplasia of the lens (HP:0008063)1.70340166
85Abnormality of renal resorption (HP:0011038)1.69709015
86Decreased activity of mitochondrial respiratory chain (HP:0008972)1.68598227
87Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.68598227
88Abnormal biliary tract morphology (HP:0012440)1.68340648
89Glioma (HP:0009733)1.67815020
90Late onset (HP:0003584)1.67452108
91Median cleft lip (HP:0000161)1.66781933
92Retinitis pigmentosa (HP:0000510)1.66436020
93Pendular nystagmus (HP:0012043)1.66038796
94Progressive cerebellar ataxia (HP:0002073)1.65906620
95Sex reversal (HP:0012245)1.65116588
96Abnormal sex determination (HP:0012244)1.65116588
97Abnormality of vitamin B metabolism (HP:0004340)1.64396910
98Inability to walk (HP:0002540)1.63098847
99Decreased central vision (HP:0007663)1.62909574
100Hyperinsulinemic hypoglycemia (HP:0000825)1.62475017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.56376258
2MAP3K42.78087742
3MST42.67785118
4ZAK2.55243798
5WNK32.47815433
6STK392.29971390
7MAP4K22.19229659
8PNCK2.17714345
9BRSK22.05656448
10CASK2.03382201
11TRIM281.99016757
12INSRR1.95314138
13MAP3K121.91586972
14BMPR1B1.89648282
15CCNB11.85660573
16SRPK11.59478061
17WNK41.59247560
18EIF2AK31.58458154
19PHKG21.56443239
20PHKG11.56443239
21MAPK151.53556935
22TSSK61.45046813
23MKNK21.43312251
24ACVR1B1.41342000
25STK38L1.38596023
26MAP2K71.37592892
27BCR1.32239829
28MKNK11.28812804
29OBSCN1.27802361
30PINK11.27670914
31FER1.25260569
32PLK31.23287201
33PAK31.22269559
34GRK11.21842124
35MARK11.18792051
36MAPK131.14150161
37MST1R1.11857648
38ERBB31.10292540
39VRK11.07776354
40OXSR11.03191400
41WEE11.00053896
42MAP2K40.97185813
43CSNK1G10.97121553
44PBK0.94898459
45TTK0.93852138
46PDK20.93838907
47PRKCE0.91601177
48TLK10.87971297
49DYRK30.86083332
50NUAK10.85745759
51RPS6KA40.85699151
52ADRBK20.84808940
53RPS6KA50.82153791
54DAPK20.80861195
55PLK10.80129639
56TIE10.78390290
57PLK20.75667582
58STK30.75587437
59NTRK30.75351502
60STK160.74761564
61EPHA30.74339033
62EIF2AK10.73797981
63CSNK1G30.73517434
64DYRK20.73386346
65PRKCI0.68751983
66CSNK1A1L0.68065810
67PLK40.67823846
68CAMK2A0.65829453
69PRKCG0.65103983
70MINK10.64907947
71BUB10.64252043
72EIF2AK20.62456312
73CSNK1G20.62228818
74NME10.62018728
75NEK10.61631668
76MAPKAPK50.57312550
77IRAK20.56165871
78MUSK0.54269826
79YES10.54002649
80CAMK2D0.53660089
81MET0.53323585
82EPHA20.51701615
83AURKB0.51670259
84IRAK10.50638794
85CDK80.49151239
86ADRBK10.48337046
87ATM0.48292916
88FGFR20.47941072
89PIK3CA0.46302370
90FLT30.45797645
91CHEK20.45109689
92MAP2K60.45013787
93PRKACB0.44316845
94TGFBR10.43937986
95PKN10.41766001
96CSNK1E0.40983090
97AKT30.40926903
98ERBB40.40719348
99LATS10.40104853
100LMTK20.39227347

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.67042581
2Butanoate metabolism_Homo sapiens_hsa006502.63142579
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.51413411
4Propanoate metabolism_Homo sapiens_hsa006402.47415726
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02720238
6Protein export_Homo sapiens_hsa030602.00088701
7Vitamin B6 metabolism_Homo sapiens_hsa007501.95301073
8Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84473419
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.80732469
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.73607097
11Selenocompound metabolism_Homo sapiens_hsa004501.72734586
12Oxidative phosphorylation_Homo sapiens_hsa001901.72225329
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71532021
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62267412
15Phototransduction_Homo sapiens_hsa047441.61861875
16Basal transcription factors_Homo sapiens_hsa030221.57826675
17RNA polymerase_Homo sapiens_hsa030201.56648926
18Circadian rhythm_Homo sapiens_hsa047101.51838769
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.50812577
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.47902715
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44806860
22Nicotine addiction_Homo sapiens_hsa050331.42813986
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41138378
24Chemical carcinogenesis_Homo sapiens_hsa052041.39312561
25Fanconi anemia pathway_Homo sapiens_hsa034601.37783380
26Steroid biosynthesis_Homo sapiens_hsa001001.35499922
27Retinol metabolism_Homo sapiens_hsa008301.33380792
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32499179
29beta-Alanine metabolism_Homo sapiens_hsa004101.28509775
30Nitrogen metabolism_Homo sapiens_hsa009101.27998336
31Peroxisome_Homo sapiens_hsa041461.27515760
32Parkinsons disease_Homo sapiens_hsa050121.21832342
33Folate biosynthesis_Homo sapiens_hsa007901.21826832
34Proteasome_Homo sapiens_hsa030501.20226846
35Linoleic acid metabolism_Homo sapiens_hsa005911.17310207
36Fatty acid metabolism_Homo sapiens_hsa012121.16786784
37Homologous recombination_Homo sapiens_hsa034401.15331802
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13496975
39Sphingolipid metabolism_Homo sapiens_hsa006001.11735005
40Tryptophan metabolism_Homo sapiens_hsa003801.10835538
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09891755
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09575620
43Huntingtons disease_Homo sapiens_hsa050161.08888496
44Fatty acid elongation_Homo sapiens_hsa000621.07498174
45Regulation of autophagy_Homo sapiens_hsa041401.06902048
46Mismatch repair_Homo sapiens_hsa034301.06470417
47RNA degradation_Homo sapiens_hsa030181.05977448
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04146963
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.02973185
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98914238
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97718785
52Tyrosine metabolism_Homo sapiens_hsa003500.97483840
53Fatty acid degradation_Homo sapiens_hsa000710.96837221
54Ether lipid metabolism_Homo sapiens_hsa005650.96536745
55Collecting duct acid secretion_Homo sapiens_hsa049660.95578267
56Purine metabolism_Homo sapiens_hsa002300.93781524
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93201646
58Non-homologous end-joining_Homo sapiens_hsa034500.91223458
59Pyruvate metabolism_Homo sapiens_hsa006200.91023260
60Starch and sucrose metabolism_Homo sapiens_hsa005000.89786777
61Taste transduction_Homo sapiens_hsa047420.89170870
62Insulin secretion_Homo sapiens_hsa049110.87807772
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86695526
64Metabolic pathways_Homo sapiens_hsa011000.85593357
65Phenylalanine metabolism_Homo sapiens_hsa003600.84318198
66Cardiac muscle contraction_Homo sapiens_hsa042600.80163014
67Nucleotide excision repair_Homo sapiens_hsa034200.79122900
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78609659
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78309165
70Histidine metabolism_Homo sapiens_hsa003400.77859958
71Pyrimidine metabolism_Homo sapiens_hsa002400.77556395
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77542174
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77035781
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73383278
75Glutathione metabolism_Homo sapiens_hsa004800.70213487
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70137271
77RNA transport_Homo sapiens_hsa030130.69041614
78ABC transporters_Homo sapiens_hsa020100.68933457
79Systemic lupus erythematosus_Homo sapiens_hsa053220.68707063
80Olfactory transduction_Homo sapiens_hsa047400.68603602
81Alzheimers disease_Homo sapiens_hsa050100.66495437
82Sulfur metabolism_Homo sapiens_hsa009200.66086495
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64418429
84GABAergic synapse_Homo sapiens_hsa047270.63575901
85Arginine biosynthesis_Homo sapiens_hsa002200.63181075
86Alcoholism_Homo sapiens_hsa050340.61798095
87Circadian entrainment_Homo sapiens_hsa047130.60891398
88One carbon pool by folate_Homo sapiens_hsa006700.60429330
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59927967
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.58191530
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56958093
92Arginine and proline metabolism_Homo sapiens_hsa003300.55684949
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55505916
94Arachidonic acid metabolism_Homo sapiens_hsa005900.53501427
95Oocyte meiosis_Homo sapiens_hsa041140.49625358
96Caffeine metabolism_Homo sapiens_hsa002320.48702106
97Carbon metabolism_Homo sapiens_hsa012000.48384993
98Salivary secretion_Homo sapiens_hsa049700.45671773
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43746178
100Serotonergic synapse_Homo sapiens_hsa047260.43467609

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