ZSCAN32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1valine metabolic process (GO:0006573)6.20937378
2mitotic sister chromatid cohesion (GO:0007064)5.16190250
3CENP-A containing nucleosome assembly (GO:0034080)5.14626724
4mitotic metaphase plate congression (GO:0007080)5.08850681
5chromatin remodeling at centromere (GO:0031055)4.87152582
6regulation of translation in response to stress (GO:0043555)4.51074513
7DNA topological change (GO:0006265)4.38731857
8metaphase plate congression (GO:0051310)4.14835597
9DNA replication-independent nucleosome assembly (GO:0006336)4.11224336
10DNA replication-independent nucleosome organization (GO:0034724)4.11224336
11histone exchange (GO:0043486)3.99549697
12establishment of chromosome localization (GO:0051303)3.90521042
13mitotic chromosome condensation (GO:0007076)3.89821403
14nuclear pore complex assembly (GO:0051292)3.73829298
15germ cell migration (GO:0008354)3.72923904
16DNA double-strand break processing (GO:0000729)3.61284159
17branched-chain amino acid catabolic process (GO:0009083)3.59073272
18regulation of sister chromatid cohesion (GO:0007063)3.56967655
19telomere maintenance via semi-conservative replication (GO:0032201)3.51561452
20folic acid-containing compound biosynthetic process (GO:0009396)3.50185377
21formation of translation preinitiation complex (GO:0001731)3.39142450
22purine nucleobase biosynthetic process (GO:0009113)3.33798660
23regulation of nuclear cell cycle DNA replication (GO:0033262)3.33115123
24negative regulation of translational initiation (GO:0045947)3.32053369
25sister chromatid cohesion (GO:0007062)3.26047962
26ribosome assembly (GO:0042255)3.21755463
27nuclear pore organization (GO:0006999)3.21742093
28cysteine metabolic process (GO:0006534)3.21323649
29gonadal mesoderm development (GO:0007506)3.20141603
30N-terminal protein amino acid acetylation (GO:0006474)3.19835348
31GMP metabolic process (GO:0046037)3.16080254
32regulation of centriole replication (GO:0046599)3.05978123
33DNA strand elongation involved in DNA replication (GO:0006271)3.00098571
34branched-chain amino acid metabolic process (GO:0009081)2.98621845
35negative regulation of DNA recombination (GO:0045910)2.97907501
36nucleotide-excision repair, DNA gap filling (GO:0006297)2.97453425
37pore complex assembly (GO:0046931)2.97048179
38DNA strand elongation (GO:0022616)2.93785800
39telomere maintenance via recombination (GO:0000722)2.93720707
40regulation of meiosis I (GO:0060631)2.92510381
41DNA integration (GO:0015074)2.91804511
42DNA catabolic process, exonucleolytic (GO:0000738)2.91375975
43L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.90210328
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.88538991
45regulation of helicase activity (GO:0051095)2.80129599
46positive regulation of B cell differentiation (GO:0045579)2.78842759
47telomere maintenance via telomere lengthening (GO:0010833)2.76401557
48regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.75555200
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.74949690
50IMP biosynthetic process (GO:0006188)2.74223515
51protein localization to kinetochore (GO:0034501)2.73912245
52establishment of integrated proviral latency (GO:0075713)2.71792834
53chromatin assembly or disassembly (GO:0006333)2.70349886
54ATP-dependent chromatin remodeling (GO:0043044)2.69954438
55protein K6-linked ubiquitination (GO:0085020)2.69167816
56mitotic recombination (GO:0006312)2.68970941
57ribosomal small subunit assembly (GO:0000028)2.67374489
58DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.66379176
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.66183072
60double-strand break repair via nonhomologous end joining (GO:0006303)2.65419953
61non-recombinational repair (GO:0000726)2.65419953
62signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.63511964
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.63511964
64signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.62590838
65signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.62590838
66signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.62590838
67mitotic nuclear envelope disassembly (GO:0007077)2.61474754
68spliceosomal tri-snRNP complex assembly (GO:0000244)2.60347942
69nucleobase biosynthetic process (GO:0046112)2.60159215
70spindle checkpoint (GO:0031577)2.59532309
71protein localization to chromosome, centromeric region (GO:0071459)2.59214374
72proteasome assembly (GO:0043248)2.57908327
73signal transduction involved in DNA damage checkpoint (GO:0072422)2.56069626
74signal transduction involved in DNA integrity checkpoint (GO:0072401)2.56069626
75histone H4-K8 acetylation (GO:0043982)2.55984582
76histone H4-K5 acetylation (GO:0043981)2.55984582
77mitotic spindle checkpoint (GO:0071174)2.55766096
78histone H2A acetylation (GO:0043968)2.55282311
79synapsis (GO:0007129)2.54036549
80signal transduction involved in cell cycle checkpoint (GO:0072395)2.53435095
81nucleoside salvage (GO:0043174)2.53254870
82negative regulation of ligase activity (GO:0051352)2.51961426
83negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.51961426
84DNA synthesis involved in DNA repair (GO:0000731)2.51947057
85G1/S transition of mitotic cell cycle (GO:0000082)2.51512801
86cell cycle G1/S phase transition (GO:0044843)2.51512801
87tRNA aminoacylation for protein translation (GO:0006418)2.50911320
88DNA-dependent DNA replication (GO:0006261)2.50232137
89metallo-sulfur cluster assembly (GO:0031163)2.49473243
90iron-sulfur cluster assembly (GO:0016226)2.49473243
91kinetochore assembly (GO:0051382)2.49362454
92DNA replication checkpoint (GO:0000076)2.48862158
93positive regulation of gamma-delta T cell activation (GO:0046645)2.48766963
94pre-miRNA processing (GO:0031054)2.47075537
95regulation of translational initiation (GO:0006446)2.46358865
96membrane disassembly (GO:0030397)2.46348290
97nuclear envelope disassembly (GO:0051081)2.46348290
98ribosome biogenesis (GO:0042254)2.46240629
99telomere maintenance (GO:0000723)2.45598649
100regulation of chromosome segregation (GO:0051983)2.44857459

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.82626161
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.90194813
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.59579566
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.57105460
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.29909604
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.22323507
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.06350862
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.04837100
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.03143367
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.01736017
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.94076430
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.88040967
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.65666294
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62982300
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51409911
16VDR_23849224_ChIP-Seq_CD4+_Human2.47731545
17FOXP3_21729870_ChIP-Seq_TREG_Human2.39981901
18FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.36132087
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.34488818
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33730559
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29925618
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.23501003
23HOXB4_20404135_ChIP-ChIP_EML_Mouse2.20412223
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.18657821
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17944350
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15896695
27DCP1A_22483619_ChIP-Seq_HELA_Human2.14699717
28CIITA_25753668_ChIP-Seq_RAJI_Human2.08736294
29MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04214610
30ELK1_19687146_ChIP-ChIP_HELA_Human2.03866585
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01702158
32MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00108132
33GABP_19822575_ChIP-Seq_HepG2_Human1.99308474
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98120859
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.98105046
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.93301298
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92961499
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88302531
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87807366
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87216637
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86393867
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85218616
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83209936
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.80130666
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.71233120
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66372406
47KDM5A_27292631_Chip-Seq_BREAST_Human1.64057572
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63285366
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.61703535
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.61315789
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58361157
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.57396594
53TFEB_21752829_ChIP-Seq_HELA_Human1.56721835
54TTF2_22483619_ChIP-Seq_HELA_Human1.56363363
55XRN2_22483619_ChIP-Seq_HELA_Human1.54697020
56MYB_26560356_Chip-Seq_TH2_Human1.54511988
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53817074
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52761893
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50499613
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48544296
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.45747236
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.42775591
63SPI1_23547873_ChIP-Seq_NB4_Human1.40639843
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38002320
65IRF8_21731497_ChIP-ChIP_J774_Mouse1.37467190
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36560490
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35264383
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.31975160
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29780853
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28091966
71MYB_26560356_Chip-Seq_TH1_Human1.20041112
72CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18967598
73IGF1R_20145208_ChIP-Seq_DFB_Human1.16367918
74IRF1_19129219_ChIP-ChIP_H3396_Human1.16339860
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16204305
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15956717
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14039204
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13475828
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11342220
80AR_21909140_ChIP-Seq_LNCAP_Human1.10977025
81IRF8_22096565_ChIP-ChIP_GC-B_Human1.09898227
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.09289336
83MYC_22102868_ChIP-Seq_BL_Human1.07083815
84MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01170511
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99604362
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97006978
87NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91322095
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91197825
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88928949
90CHD1_26751641_Chip-Seq_LNCaP_Human0.85937620
91ZNF274_21170338_ChIP-Seq_K562_Hela0.85821272
92SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85223585
93RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85092608
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84763694
95MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80914661
96STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80617760
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.80541985
98KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.80541985
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.80541985
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79315918

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.27598022
2MP0008057_abnormal_DNA_replication3.76070983
3MP0010094_abnormal_chromosome_stability3.43124950
4MP0003111_abnormal_nucleus_morphology3.36421809
5MP0003693_abnormal_embryo_hatching3.36044436
6MP0003077_abnormal_cell_cycle3.03416477
7MP0003656_abnormal_erythrocyte_physiolo2.77541632
8MP0003806_abnormal_nucleotide_metabolis2.77499816
9MP0008877_abnormal_DNA_methylation2.49793832
10MP0002822_catalepsy2.47920160
11MP0004957_abnormal_blastocyst_morpholog2.44024124
12MP0003718_maternal_effect2.40643537
13MP0002396_abnormal_hematopoietic_system2.29396299
14MP0008007_abnormal_cellular_replicative2.07189742
15MP0001188_hyperpigmentation2.06557387
16MP0008260_abnormal_autophagy2.04260133
17MP0005075_abnormal_melanosome_morpholog2.00595050
18MP0006292_abnormal_olfactory_placode1.90327887
19MP0003763_abnormal_thymus_physiology1.68466945
20MP0000703_abnormal_thymus_morphology1.68432206
21MP0002398_abnormal_bone_marrow1.65224933
22MP0001873_stomach_inflammation1.62913224
23MP0004147_increased_porphyrin_level1.61720619
24MP0006035_abnormal_mitochondrial_morpho1.59504462
25MP0005671_abnormal_response_to1.57747129
26MP0008932_abnormal_embryonic_tissue1.56103475
27MP0003786_premature_aging1.55180042
28MP0001800_abnormal_humoral_immune1.52588889
29MP0002132_abnormal_respiratory_system1.51281794
30MP0002722_abnormal_immune_system1.48873397
31MP0003724_increased_susceptibility_to1.46247351
32MP0000689_abnormal_spleen_morphology1.45982818
33MP0001730_embryonic_growth_arrest1.44200672
34MP0001853_heart_inflammation1.43207368
35MP0001835_abnormal_antigen_presentation1.42498218
36MP0002405_respiratory_system_inflammati1.40593637
37MP0005367_renal/urinary_system_phenotyp1.39623638
38MP0000516_abnormal_urinary_system1.39623638
39MP0003828_pulmonary_edema1.35390118
40MP0004381_abnormal_hair_follicle1.35163109
41MP0002277_abnormal_respiratory_mucosa1.32900052
42MP0009333_abnormal_splenocyte_physiolog1.32035743
43MP0000350_abnormal_cell_proliferation1.31943944
44MP0002420_abnormal_adaptive_immunity1.31850373
45MP0003436_decreased_susceptibility_to1.31839034
46MP0005000_abnormal_immune_tolerance1.29965080
47MP0002723_abnormal_immune_serum1.29872133
48MP0001819_abnormal_immune_cell1.28582217
49MP0000490_abnormal_crypts_of1.27558261
50MP0002254_reproductive_system_inflammat1.25814173
51MP0001929_abnormal_gametogenesis1.22653404
52MP0000313_abnormal_cell_death1.20906647
53MP0000716_abnormal_immune_system1.20475898
54MP0005387_immune_system_phenotype1.20381749
55MP0001790_abnormal_immune_system1.20381749
56MP0002210_abnormal_sex_determination1.18984300
57MP0008995_early_reproductive_senescence1.15197831
58MP0003191_abnormal_cellular_cholesterol1.14008805
59MP0001672_abnormal_embryogenesis/_devel1.13825503
60MP0005380_embryogenesis_phenotype1.13825503
61MP0002429_abnormal_blood_cell1.13072489
62MP0002452_abnormal_antigen_presenting1.11133874
63MP0000685_abnormal_immune_system1.07788672
64MP0002080_prenatal_lethality1.05871542
65MP0002638_abnormal_pupillary_reflex1.05284283
66MP0003941_abnormal_skin_development1.05205857
67MP0001764_abnormal_homeostasis1.04697770
68MP0001697_abnormal_embryo_size1.04464573
69MP0001145_abnormal_male_reproductive1.03189059
70MP0005310_abnormal_salivary_gland1.03132064
71MP0002019_abnormal_tumor_incidence1.02986505
72MP0000372_irregular_coat_pigmentation1.00676601
73MP0000015_abnormal_ear_pigmentation1.00179303
74MP0005645_abnormal_hypothalamus_physiol0.98654021
75MP0005174_abnormal_tail_pigmentation0.97883070
76MP0000013_abnormal_adipose_tissue0.96918099
77MP0009785_altered_susceptibility_to0.96268906
78MP0003984_embryonic_growth_retardation0.93643023
79MP0002088_abnormal_embryonic_growth/wei0.92949698
80MP0002148_abnormal_hypersensitivity_rea0.91080512
81MP0002086_abnormal_extraembryonic_tissu0.90615363
82MP0005248_abnormal_Harderian_gland0.88849001
83MP0004197_abnormal_fetal_growth/weight/0.87998297
84MP0002419_abnormal_innate_immunity0.87573802
85MP0003186_abnormal_redox_activity0.86225378
86MP0000653_abnormal_sex_gland0.84609245
87MP0004808_abnormal_hematopoietic_stem0.81106635
88MP0006036_abnormal_mitochondrial_physio0.80650920
89MP0000613_abnormal_salivary_gland0.80081378
90MP0003890_abnormal_embryonic-extraembry0.79357362
91MP0000358_abnormal_cell_content/0.77321047
92MP0010307_abnormal_tumor_latency0.75982907
93MP0003221_abnormal_cardiomyocyte_apopto0.75589977
94MP0002095_abnormal_skin_pigmentation0.75451929
95MP0001286_abnormal_eye_development0.74275347
96MP0005025_abnormal_response_to0.74186671
97MP0002735_abnormal_chemical_nociception0.72578679
98MP0005384_cellular_phenotype0.72299929
99MP0005621_abnormal_cell_physiology0.71463540
100MP0004947_skin_inflammation0.71441852

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.98088095
2Abnormality of fatty-acid metabolism (HP:0004359)3.92291308
3Cerebral hypomyelination (HP:0006808)3.21237275
4Medulloblastoma (HP:0002885)3.09201046
5Absent rod-and cone-mediated responses on ERG (HP:0007688)2.95873686
6Severe combined immunodeficiency (HP:0004430)2.89912128
7Combined immunodeficiency (HP:0005387)2.88426350
8Premature ovarian failure (HP:0008209)2.86696340
9IgM deficiency (HP:0002850)2.80099868
10Agammaglobulinemia (HP:0004432)2.78918767
11Postnatal microcephaly (HP:0005484)2.67769453
12Abnormal lung lobation (HP:0002101)2.64301942
13B lymphocytopenia (HP:0010976)2.63945270
14T lymphocytopenia (HP:0005403)2.62639816
15Pustule (HP:0200039)2.56342203
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.54400474
17Microvesicular hepatic steatosis (HP:0001414)2.53747929
18Increased hepatocellular lipid droplets (HP:0006565)2.53056932
19Respiratory difficulties (HP:0002880)2.52793365
20Lipid accumulation in hepatocytes (HP:0006561)2.52437190
21Osteomyelitis (HP:0002754)2.49702690
22Chromsome breakage (HP:0040012)2.47882670
23Abnormality of B cell number (HP:0010975)2.43311989
24Constricted visual fields (HP:0001133)2.39223377
25Squamous cell carcinoma (HP:0002860)2.38554245
26Autoimmune hemolytic anemia (HP:0001890)2.37756406
27Recurrent viral infections (HP:0004429)2.37251452
28Panhypogammaglobulinemia (HP:0003139)2.35675680
29IgG deficiency (HP:0004315)2.34834799
30Basal cell carcinoma (HP:0002671)2.34190770
31Abnormality of T cell number (HP:0011839)2.32196891
32Intestinal atresia (HP:0011100)2.30828847
33Acute hepatic failure (HP:0006554)2.24543563
34Bile duct proliferation (HP:0001408)2.23782820
35Abnormal biliary tract physiology (HP:0012439)2.23782820
36Acute myeloid leukemia (HP:0004808)2.18973649
37Myelodysplasia (HP:0002863)2.16017736
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.13471947
39Progressive external ophthalmoplegia (HP:0000590)2.12231133
40Abnormal sex determination (HP:0012244)2.11494435
41Sex reversal (HP:0012245)2.11494435
42Prominent metopic ridge (HP:0005487)2.10811734
43Stomatitis (HP:0010280)2.06734030
44Abnormality of the metopic suture (HP:0005556)2.05580363
453-Methylglutaconic aciduria (HP:0003535)2.04893971
46Leukocytosis (HP:0001974)2.04842196
47Abnormality of chromosome stability (HP:0003220)2.04519359
48Nephroblastoma (Wilms tumor) (HP:0002667)2.02292308
49Encephalitis (HP:0002383)2.00905076
50Personality changes (HP:0000751)2.00760448
51Large eyes (HP:0001090)2.00408722
52Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00288938
53Recurrent fungal infections (HP:0002841)1.96837983
54Bicuspid aortic valve (HP:0001647)1.94670011
55Aplasia/Hypoplasia of the thymus (HP:0010515)1.94400363
56Recurrent bacterial skin infections (HP:0005406)1.94194442
57Decreased activity of mitochondrial respiratory chain (HP:0008972)1.92434334
58Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.92434334
59Horseshoe kidney (HP:0000085)1.92048441
60Hypoglycemic seizures (HP:0002173)1.91125405
61Colon cancer (HP:0003003)1.90980996
62Abnormality of eosinophils (HP:0001879)1.90095774
63Cellular immunodeficiency (HP:0005374)1.87778434
64Abnormality of the thymus (HP:0000777)1.87546762
65Increased density of long bones (HP:0006392)1.87403859
66Pancytopenia (HP:0001876)1.82915694
67Delusions (HP:0000746)1.81684009
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.81242546
69Recurrent abscess formation (HP:0002722)1.81208583
70Embryonal renal neoplasm (HP:0011794)1.81188674
71Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81055377
72Progressive inability to walk (HP:0002505)1.80967560
73Hypochromic microcytic anemia (HP:0004840)1.80670376
74Hyperinsulinemic hypoglycemia (HP:0000825)1.78592923
75Petechiae (HP:0000967)1.78558584
76Opisthotonus (HP:0002179)1.77948469
77Loss of speech (HP:0002371)1.77014727
78Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.75990021
79Abnormality of T cells (HP:0002843)1.75104053
80Embryonal neoplasm (HP:0002898)1.74827094
81Pancreatic fibrosis (HP:0100732)1.74683014
82Oligodactyly (hands) (HP:0001180)1.74256843
83Poikiloderma (HP:0001029)1.71601058
84Eosinophilia (HP:0001880)1.71310831
85Granulocytopenia (HP:0001913)1.70667532
86Unsteady gait (HP:0002317)1.70326488
87Secondary amenorrhea (HP:0000869)1.70058279
88Chronic mucocutaneous candidiasis (HP:0002728)1.68675701
89Recurrent cutaneous fungal infections (HP:0011370)1.68675701
90IgA deficiency (HP:0002720)1.68172770
91Generalized myoclonic seizures (HP:0002123)1.67555535
92Thyroiditis (HP:0100646)1.66887607
93Symptomatic seizures (HP:0011145)1.66029101
94Cleft eyelid (HP:0000625)1.65747558
95Lymphoma (HP:0002665)1.65511344
96Oligodactyly (HP:0012165)1.65315903
97Meningitis (HP:0001287)1.65187810
98CNS hypomyelination (HP:0003429)1.64835517
99Abnormality of the preputium (HP:0100587)1.64341386
100Vasculitis (HP:0002633)1.63808232

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.41543606
2TAOK14.33894019
3SRPK14.21134742
4CDC73.60669131
5SIK33.23182349
6PBK3.02463100
7TGFBR22.93618321
8VRK22.61996516
9ZAK2.30485218
10CDK192.30340671
11EIF2AK32.29230669
12EIF2AK12.23529610
13BUB11.90889845
14TTK1.77243926
15VRK11.76788034
16IRAK41.76459321
17PIM21.65873617
18ACVR1B1.62803786
19MARK31.58364970
20MAP3K141.53695015
21SCYL21.52681376
22PASK1.42711353
23BRD41.36975646
24NEK11.35692053
25TAF11.32119115
26MKNK11.27488396
27MAP3K101.21270842
28BRSK21.19370310
29SIK21.18148065
30BMPR1B1.12612961
31CHEK21.12500285
32CDK71.11367801
33STK38L1.08741976
34CDK81.06905990
35WNK31.02154297
36FES1.02034943
37MKNK20.99153340
38PLK30.98056189
39AURKB0.95799018
40TLK10.95598685
41TIE10.95240893
42CCNB10.95180374
43ATR0.92179640
44FGR0.91427314
45NEK60.90211475
46CDK60.88792579
47YES10.87088639
48KIT0.87082472
49CLK10.87000372
50LATS10.83323797
51MAP4K20.82549153
52PRPF4B0.81823136
53BRSK10.80328823
54PLK10.79438468
55KSR10.79296151
56PIM10.78121137
57ERN10.75640745
58BCR0.74371601
59WEE10.73502381
60NEK20.72460644
61CHEK10.69096871
62CDK120.67977240
63TGFBR10.66255132
64ATM0.65730472
65TSSK60.64697234
66CDK40.63825951
67STK40.61219610
68MATK0.60931837
69CDK90.60660281
70DYRK30.60508889
71MAP3K130.59143127
72MAP3K50.59104220
73PNCK0.57634735
74MAP4K10.55539042
75ALK0.51752001
76BCKDK0.51555525
77MAP3K10.47077461
78TEC0.46061863
79STK100.44744472
80RAF10.43929260
81PLK40.43601989
82CDK30.42803903
83HCK0.41656598
84EIF2AK20.40095498
85GRK60.38882245
86LYN0.38049310
87RPS6KB20.37114547
88CSK0.36796457
89RPS6KB10.36094215
90DYRK1B0.35984542
91JAK20.34714228
92STK390.33410040
93CDK20.32989832
94WNK10.32047770
95AURKA0.31653690
96CAMK1G0.30769957
97CSNK2A20.30682936
98PRKCQ0.30654298
99JAK30.29908477
100NUAK10.28876382

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.99628167
2Proteasome_Homo sapiens_hsa030503.71532374
3DNA replication_Homo sapiens_hsa030303.46023501
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93689768
5Non-homologous end-joining_Homo sapiens_hsa034502.90006387
6Homologous recombination_Homo sapiens_hsa034402.80083142
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.79165320
8Base excision repair_Homo sapiens_hsa034102.74646948
9Nucleotide excision repair_Homo sapiens_hsa034202.67511550
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43157591
11Basal transcription factors_Homo sapiens_hsa030222.39843644
12Sulfur relay system_Homo sapiens_hsa041222.38396384
13RNA transport_Homo sapiens_hsa030132.32792736
14RNA polymerase_Homo sapiens_hsa030202.27574553
15Spliceosome_Homo sapiens_hsa030402.22540094
16Fanconi anemia pathway_Homo sapiens_hsa034602.22175141
17Cell cycle_Homo sapiens_hsa041102.14972464
18Primary immunodeficiency_Homo sapiens_hsa053401.85005691
19One carbon pool by folate_Homo sapiens_hsa006701.82254700
20mRNA surveillance pathway_Homo sapiens_hsa030151.72141340
21RNA degradation_Homo sapiens_hsa030181.59760120
22Propanoate metabolism_Homo sapiens_hsa006401.53621646
23Pyrimidine metabolism_Homo sapiens_hsa002401.53454867
24Folate biosynthesis_Homo sapiens_hsa007901.47407974
25p53 signaling pathway_Homo sapiens_hsa041151.47309223
26Epstein-Barr virus infection_Homo sapiens_hsa051691.39569399
27Measles_Homo sapiens_hsa051621.32545190
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.30658119
29Herpes simplex infection_Homo sapiens_hsa051681.20520736
30Protein export_Homo sapiens_hsa030601.19993915
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17540601
32Hepatitis B_Homo sapiens_hsa051611.15984567
33Ribosome_Homo sapiens_hsa030101.14938786
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12672374
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.07918606
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07475199
37Fatty acid elongation_Homo sapiens_hsa000621.05582170
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04424463
39Purine metabolism_Homo sapiens_hsa002300.99023044
40Viral carcinogenesis_Homo sapiens_hsa052030.94050667
41Regulation of autophagy_Homo sapiens_hsa041400.91892361
42Osteoclast differentiation_Homo sapiens_hsa043800.84775879
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83476413
44Chronic myeloid leukemia_Homo sapiens_hsa052200.83263126
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79202458
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76451841
47mTOR signaling pathway_Homo sapiens_hsa041500.76341922
48Fatty acid metabolism_Homo sapiens_hsa012120.75864663
49Legionellosis_Homo sapiens_hsa051340.75637953
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75089966
51Pancreatic cancer_Homo sapiens_hsa052120.72797915
52Oocyte meiosis_Homo sapiens_hsa041140.67468600
53Influenza A_Homo sapiens_hsa051640.65339056
54Acute myeloid leukemia_Homo sapiens_hsa052210.65076169
55HTLV-I infection_Homo sapiens_hsa051660.60973388
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60317816
57Carbon metabolism_Homo sapiens_hsa012000.60261526
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58783938
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57859622
60T cell receptor signaling pathway_Homo sapiens_hsa046600.57784528
61Colorectal cancer_Homo sapiens_hsa052100.57491762
62Non-small cell lung cancer_Homo sapiens_hsa052230.57110826
63Selenocompound metabolism_Homo sapiens_hsa004500.55308253
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.54630854
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54280564
66Steroid biosynthesis_Homo sapiens_hsa001000.51258252
67MicroRNAs in cancer_Homo sapiens_hsa052060.51000984
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50910848
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50146726
70Leishmaniasis_Homo sapiens_hsa051400.50032740
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48418878
72Other glycan degradation_Homo sapiens_hsa005110.48350132
73Apoptosis_Homo sapiens_hsa042100.46207272
74B cell receptor signaling pathway_Homo sapiens_hsa046620.45532326
75Pyruvate metabolism_Homo sapiens_hsa006200.45084898
76Prostate cancer_Homo sapiens_hsa052150.44431551
77Peroxisome_Homo sapiens_hsa041460.44361459
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.43882879
79Hematopoietic cell lineage_Homo sapiens_hsa046400.42344831
80Shigellosis_Homo sapiens_hsa051310.41933614
81FoxO signaling pathway_Homo sapiens_hsa040680.41744262
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40842240
83Tuberculosis_Homo sapiens_hsa051520.38411418
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38074604
85TGF-beta signaling pathway_Homo sapiens_hsa043500.37502572
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37330296
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33130326
88Hepatitis C_Homo sapiens_hsa051600.32992201
89Glutathione metabolism_Homo sapiens_hsa004800.32458171
90Lysosome_Homo sapiens_hsa041420.30274084
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29009571
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28147115
93Antigen processing and presentation_Homo sapiens_hsa046120.27700112
94Lysine degradation_Homo sapiens_hsa003100.27195494
95Small cell lung cancer_Homo sapiens_hsa052220.22394320
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21675650
97HIF-1 signaling pathway_Homo sapiens_hsa040660.20158348
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19704744
99Graft-versus-host disease_Homo sapiens_hsa053320.19428038
100Systemic lupus erythematosus_Homo sapiens_hsa053220.18302291

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