ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.22220422
2	DNA deamination (GO:0045006)	4.37123943
3	piRNA metabolic process (GO:0034587)	4.07025356
4	indolalkylamine metabolic process (GO:0006586)	4.02128193
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.98346295
6	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.90971683
7	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.90971683
8	NADH dehydrogenase complex assembly (GO:0010257)	3.90971683
9	indole-containing compound catabolic process (GO:0042436)	3.90890446
10	indolalkylamine catabolic process (GO:0046218)	3.90890446
11	tryptophan catabolic process (GO:0006569)	3.90890446
12	water-soluble vitamin biosynthetic process (GO:0042364)	3.72199885
13	kynurenine metabolic process (GO:0070189)	3.69047753
14	fucose catabolic process (GO:0019317)	3.59247320
15	L-fucose metabolic process (GO:0042354)	3.59247320
16	L-fucose catabolic process (GO:0042355)	3.59247320
17	DNA methylation involved in gamete generation (GO:0043046)	3.57409788
18	regulation of cilium movement (GO:0003352)	3.56896594
19	cellular ketone body metabolic process (GO:0046950)	3.56440756
20	protein complex biogenesis (GO:0070271)	3.55018461
21	epithelial cilium movement (GO:0003351)	3.54814101
22	tryptophan metabolic process (GO:0006568)	3.51153480
23	protein-cofactor linkage (GO:0018065)	3.48151521
24	mitochondrial respiratory chain complex assembly (GO:0033108)	3.41363453
25	protein polyglutamylation (GO:0018095)	3.35322008
26	platelet dense granule organization (GO:0060155)	3.33768993
27	multicellular organism reproduction (GO:0032504)	3.27823526
28	preassembly of GPI anchor in ER membrane (GO:0016254)	3.21098858
29	response to pheromone (GO:0019236)	3.16301531
30	cilium or flagellum-dependent cell motility (GO:0001539)	3.15429846
31	ketone body metabolic process (GO:1902224)	3.13363420
32	detection of light stimulus involved in visual perception (GO:0050908)	3.11574619
33	detection of light stimulus involved in sensory perception (GO:0050962)	3.11574619
34	mannosylation (GO:0097502)	3.10058363
35	axoneme assembly (GO:0035082)	3.08753196
36	sperm motility (GO:0030317)	3.06653824
37	axonemal dynein complex assembly (GO:0070286)	3.04394191
38	cilium movement (GO:0003341)	3.04149118
39	synapsis (GO:0007129)	3.03348104
40	cellular biogenic amine catabolic process (GO:0042402)	3.02966206
41	amine catabolic process (GO:0009310)	3.02966206
42	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.98282051
43	respiratory chain complex IV assembly (GO:0008535)	2.92433814
44	indole-containing compound metabolic process (GO:0042430)	2.92408702
45	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.91912040
46	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.89136902
47	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.88688060
48	ATP synthesis coupled proton transport (GO:0015986)	2.88688060
49	nonmotile primary cilium assembly (GO:0035058)	2.86530184
50	male meiosis (GO:0007140)	2.83818218
51	negative regulation of telomere maintenance (GO:0032205)	2.83811934
52	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.83357117
53	sulfation (GO:0051923)	2.78506490
54	negative regulation of mast cell activation (GO:0033004)	2.78300197
55	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.75940218
56	ubiquinone biosynthetic process (GO:0006744)	2.75833948
57	base-excision repair, AP site formation (GO:0006285)	2.75219244
58	male meiosis I (GO:0007141)	2.73782228
59	somite development (GO:0061053)	2.72483741
60	regulation of microtubule-based movement (GO:0060632)	2.71349528
61	rRNA catabolic process (GO:0016075)	2.68780040
62	cilium morphogenesis (GO:0060271)	2.67321697
63	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.67203248
64	pseudouridine synthesis (GO:0001522)	2.64598537
65	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.63979323
66	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.63979323
67	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.63183530
68	termination of RNA polymerase III transcription (GO:0006386)	2.63183530
69	protein import into peroxisome matrix (GO:0016558)	2.62785465
70	regulation of action potential (GO:0098900)	2.62662391
71	neuronal action potential (GO:0019228)	2.61421633
72	reciprocal meiotic recombination (GO:0007131)	2.59596329
73	reciprocal DNA recombination (GO:0035825)	2.59596329
74	cytochrome complex assembly (GO:0017004)	2.57092666
75	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.57046344
76	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.56757335
77	positive regulation of fatty acid transport (GO:2000193)	2.55000919
78	gamma-aminobutyric acid transport (GO:0015812)	2.54565037
79	tRNA processing (GO:0008033)	2.53795675
80	ubiquinone metabolic process (GO:0006743)	2.53779199
81	photoreceptor cell development (GO:0042461)	2.53199726
82	L-methionine salvage (GO:0071267)	2.52311748
83	L-methionine biosynthetic process (GO:0071265)	2.52311748
84	amino acid salvage (GO:0043102)	2.52311748
85	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.52276254
86	negative regulation of systemic arterial blood pressure (GO:0003085)	2.49611322
87	peptidyl-histidine modification (GO:0018202)	2.48321588
88	neural tube formation (GO:0001841)	2.47761647
89	positive regulation of prostaglandin secretion (GO:0032308)	2.47706193
90	GPI anchor metabolic process (GO:0006505)	2.45303264
91	kidney morphogenesis (GO:0060993)	2.45077630
92	photoreceptor cell maintenance (GO:0045494)	2.44771448
93	intracellular protein transmembrane import (GO:0044743)	2.44538479
94	mitochondrion morphogenesis (GO:0070584)	2.44268767
95	recombinational repair (GO:0000725)	2.43385427
96	retinal cone cell development (GO:0046549)	2.42663691
97	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.41840633
98	cilium organization (GO:0044782)	2.41385030
99	double-strand break repair via homologous recombination (GO:0000724)	2.41102813
100	acrosome reaction (GO:0007340)	2.40841248

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* ZNF274_21170338_ChIP-Seq_K562_Hela	4.14568126
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.51844425
3	VDR_22108803_ChIP-Seq_LS180_Human	3.48640890
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.78338524
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.71212785
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.49257501
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.47842677
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.43884540
9	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.30088047
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.29209293
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.22528799
12	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.17489794
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.13246470
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.02681611
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.00882278
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.00316985
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.98450642
18	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.95063812
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.94246376
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.90516671
21	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.90142260
22	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.88341899
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.87599986
24	FUS_26573619_Chip-Seq_HEK293_Human	1.85119984
25	EWS_26573619_Chip-Seq_HEK293_Human	1.81769804
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.72874533
27	P300_19829295_ChIP-Seq_ESCs_Human	1.72549588
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.72322564
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.70774919
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.66755650
31	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.58875810
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53526335
33	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.52282123
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.49637896
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45468280
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42902815
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.42902815
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41471778
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.41471778
40	AR_21572438_ChIP-Seq_LNCaP_Human	1.41065204
41	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.40071578
42	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.39515392
43	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.34897148
44	VDR_23849224_ChIP-Seq_CD4+_Human	1.34097801
45	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.33859016
46	AR_25329375_ChIP-Seq_VCAP_Human	1.32627908
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.31349578
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.31349578
49	NCOR_22424771_ChIP-Seq_293T_Human	1.29588231
50	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.27896629
51	STAT3_23295773_ChIP-Seq_U87_Human	1.27128084
52	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25883825
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25702923
54	REST_21632747_ChIP-Seq_MESCs_Mouse	1.25156281
55	* BCAT_22108803_ChIP-Seq_LS180_Human	1.24772445
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24176529
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24176529
58	SMAD4_21799915_ChIP-Seq_A2780_Human	1.20910287
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.20104247
60	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.19289751
61	TCF4_23295773_ChIP-Seq_U87_Human	1.19058032
62	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.18067486
63	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.17558399
64	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16738005
65	RNF2_27304074_Chip-Seq_NSC_Mouse	1.16608372
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15740074
67	HOXB7_26014856_ChIP-Seq_BT474_Human	1.15191820
68	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14961653
69	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.13879772
70	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.13575488
71	ERA_21632823_ChIP-Seq_H3396_Human	1.13552973
72	AR_20517297_ChIP-Seq_VCAP_Human	1.13303106
73	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12361467
74	ELK1_19687146_ChIP-ChIP_HELA_Human	1.12054714
75	TCF4_22108803_ChIP-Seq_LS180_Human	1.10647719
76	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.10149794
77	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.09945064
78	MYC_19829295_ChIP-Seq_ESCs_Human	1.09140215
79	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07783666
80	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.07636834
81	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.07457012
82	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06730861
83	* PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05660253
84	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05482628
85	NANOG_20526341_ChIP-Seq_ESCs_Human	1.04629702
86	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03479221
87	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.02178883
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01782978
89	ETV1_20927104_ChIP-Seq_GIST48_Human	0.98904641
90	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.97671834
91	TAF2_19829295_ChIP-Seq_ESCs_Human	0.95618040
92	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.95496856
93	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.95151417
94	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.94472376
95	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.93429119
96	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.91828334
97	RBPJ_21746931_ChIP-Seq_IB4_Human	0.90627729
98	PHF8_20622853_ChIP-Seq_HELA_Human	0.90034995
99	OCT4_20526341_ChIP-Seq_ESCs_Human	0.89024772
100	FOXP3_21729870_ChIP-Seq_TREG_Human	0.87829842

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.00868738
2	MP0002837_dystrophic_cardiac_calcinosis	2.92178793
3	MP0003195_calcinosis	2.70525949
4	MP0002102_abnormal_ear_morphology	2.50338136
5	MP0003646_muscle_fatigue	2.40276410
6	MP0005551_abnormal_eye_electrophysiolog	2.29392909
7	MP0000569_abnormal_digit_pigmentation	2.23212044
8	MP0001968_abnormal_touch/_nociception	2.21774098
9	MP0003011_delayed_dark_adaptation	2.20373292
10	MP0005410_abnormal_fertilization	2.20354619
11	MP0005646_abnormal_pituitary_gland	2.13945940
12	MP0006072_abnormal_retinal_apoptosis	2.00649066
13	MP0002638_abnormal_pupillary_reflex	1.98356967
14	MP0001986_abnormal_taste_sensitivity	1.98042659
15	MP0006292_abnormal_olfactory_placode	1.95125518
16	MP0008872_abnormal_physiological_respon	1.90222436
17	MP0009046_muscle_twitch	1.84981218
18	MP0001501_abnormal_sleep_pattern	1.82946556
19	MP0005253_abnormal_eye_physiology	1.77970089
20	MP0002736_abnormal_nociception_after	1.77332573
21	MP0003718_maternal_effect	1.74939037
22	MP0001485_abnormal_pinna_reflex	1.73711346
23	MP0009745_abnormal_behavioral_response	1.73345802
24	MP0004142_abnormal_muscle_tone	1.71630971
25	MP0004133_heterotaxia	1.71256615
26	MP0005389_reproductive_system_phenotype	1.68758935
27	MP0002160_abnormal_reproductive_system	1.66965319
28	MP0008875_abnormal_xenobiotic_pharmacok	1.64340318
29	MP0000372_irregular_coat_pigmentation	1.64053681
30	MP0002735_abnormal_chemical_nociception	1.52412309
31	MP0001529_abnormal_vocalization	1.49655934
32	MP0003136_yellow_coat_color	1.49232390
33	MP0002653_abnormal_ependyma_morphology	1.49152928
34	MP0002272_abnormal_nervous_system	1.47124427
35	MP0004147_increased_porphyrin_level	1.42518481
36	MP0003787_abnormal_imprinting	1.41338712
37	MP0002138_abnormal_hepatobiliary_system	1.41019968
38	MP0004742_abnormal_vestibular_system	1.40938682
39	MP0000631_abnormal_neuroendocrine_gland	1.40283146
40	MP0004885_abnormal_endolymph	1.33521263
41	MP0002876_abnormal_thyroid_physiology	1.33187317
42	MP0004043_abnormal_pH_regulation	1.32154385
43	MP0001919_abnormal_reproductive_system	1.31421540
44	MP0003698_abnormal_male_reproductive	1.27979627
45	MP0001984_abnormal_olfaction	1.27517129
46	MP0002938_white_spotting	1.27154860
47	MP0009764_decreased_sensitivity_to	1.26779605
48	MP0005084_abnormal_gallbladder_morpholo	1.23853095
49	MP0001486_abnormal_startle_reflex	1.23563552
50	MP0006276_abnormal_autonomic_nervous	1.23307811
51	MP0002733_abnormal_thermal_nociception	1.23062749
52	MP0001905_abnormal_dopamine_level	1.23039008
53	MP0001929_abnormal_gametogenesis	1.21821756
54	MP0005195_abnormal_posterior_eye	1.18929015
55	MP0005645_abnormal_hypothalamus_physiol	1.18439837
56	MP0002572_abnormal_emotion/affect_behav	1.18385564
57	MP0001970_abnormal_pain_threshold	1.16020729
58	MP0010386_abnormal_urinary_bladder	1.14566100
59	MP0002210_abnormal_sex_determination	1.13635080
60	MP0002064_seizures	1.12391302
61	MP0000049_abnormal_middle_ear	1.10511646
62	MP0001764_abnormal_homeostasis	1.10227244
63	MP0005386_behavior/neurological_phenoty	1.10183226
64	MP0004924_abnormal_behavior	1.10183226
65	MP0002928_abnormal_bile_duct	1.10056585
66	MP0002557_abnormal_social/conspecific_i	1.05333132
67	MP0008995_early_reproductive_senescence	1.04431078
68	MP0002163_abnormal_gland_morphology	1.03986331
69	MP0008058_abnormal_DNA_repair	1.03131951
70	MP0005379_endocrine/exocrine_gland_phen	1.01407588
71	MP0006035_abnormal_mitochondrial_morpho	1.00314896
72	MP0002067_abnormal_sensory_capabilities	0.98077590
73	MP0003635_abnormal_synaptic_transmissio	0.95471289
74	MP0005174_abnormal_tail_pigmentation	0.95191154
75	MP0000026_abnormal_inner_ear	0.94993254
76	MP0005670_abnormal_white_adipose	0.94801869
77	MP0000653_abnormal_sex_gland	0.93595970
78	MP0005367_renal/urinary_system_phenotyp	0.93114674
79	MP0000516_abnormal_urinary_system	0.93114674
80	MP0008789_abnormal_olfactory_epithelium	0.91396458
81	MP0003119_abnormal_digestive_system	0.89867602
82	MP0001324_abnormal_eye_pigmentation	0.89362564
83	MP0002095_abnormal_skin_pigmentation	0.89010786
84	MP0004145_abnormal_muscle_electrophysio	0.88702948
85	MP0002063_abnormal_learning/memory/cond	0.88462515
86	MP0000230_abnormal_systemic_arterial	0.88127050
87	MP0002229_neurodegeneration	0.86125849
88	MP0002752_abnormal_somatic_nervous	0.86037452
89	MP0001145_abnormal_male_reproductive	0.84550749
90	MP0004130_abnormal_muscle_cell	0.84330310
91	MP0000427_abnormal_hair_cycle	0.84327544
92	MP0004215_abnormal_myocardial_fiber	0.83422445
93	MP0005167_abnormal_blood-brain_barrier	0.83268573
94	MP0006036_abnormal_mitochondrial_physio	0.82941403
95	MP0003252_abnormal_bile_duct	0.81071477
96	MP0005377_hearing/vestibular/ear_phenot	0.81066700
97	MP0003878_abnormal_ear_physiology	0.81066700
98	MP0002734_abnormal_mechanical_nocicepti	0.80716732
99	MP0001963_abnormal_hearing_physiology	0.80229985
100	MP0003880_abnormal_central_pattern	0.80113164

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.21306687
2	Pancreatic fibrosis (HP:0100732)	3.88205992
3	True hermaphroditism (HP:0010459)	3.82961074
4	Type II lissencephaly (HP:0007260)	3.81981508
5	Abnormality of midbrain morphology (HP:0002418)	3.79690429
6	Molar tooth sign on MRI (HP:0002419)	3.79690429
7	Congenital stationary night blindness (HP:0007642)	3.66691677
8	Nephronophthisis (HP:0000090)	3.34141501
9	Abnormality of alanine metabolism (HP:0010916)	3.23316079
10	Hyperalaninemia (HP:0003348)	3.23316079
11	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.23316079
12	Acute necrotizing encephalopathy (HP:0006965)	2.87140614
13	Medial flaring of the eyebrow (HP:0010747)	2.86599598
14	Abnormality of the renal medulla (HP:0100957)	2.86583042
15	Absent/shortened dynein arms (HP:0200106)	2.83793828
16	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.83793828
17	Pendular nystagmus (HP:0012043)	2.81659982
18	Abnormality of the renal cortex (HP:0011035)	2.81541125
19	Abnormal respiratory motile cilium morphology (HP:0005938)	2.69905561
20	Abnormal respiratory epithelium morphology (HP:0012253)	2.69905561
21	Congenital, generalized hypertrichosis (HP:0004540)	2.69680436
22	Abolished electroretinogram (ERG) (HP:0000550)	2.62454485
23	Acute encephalopathy (HP:0006846)	2.58366858
24	Cystic liver disease (HP:0006706)	2.58203379
25	Mitochondrial inheritance (HP:0001427)	2.57713906
26	Hyperventilation (HP:0002883)	2.55012267
27	Attenuation of retinal blood vessels (HP:0007843)	2.54634546
28	Abnormal ciliary motility (HP:0012262)	2.53124087
29	Cerebellar dysplasia (HP:0007033)	2.50028431
30	Increased CSF lactate (HP:0002490)	2.48950720
31	Abnormal mitochondria in muscle tissue (HP:0008316)	2.48436766
32	Retinal dysplasia (HP:0007973)	2.43314608
33	Progressive macrocephaly (HP:0004481)	2.42172210
34	Methylmalonic acidemia (HP:0002912)	2.39636464
35	Chronic hepatic failure (HP:0100626)	2.36367467
36	Abnormal rod and cone electroretinograms (HP:0008323)	2.35189830
37	Gait imbalance (HP:0002141)	2.32917874
38	Sclerocornea (HP:0000647)	2.32582918
39	Abnormal biliary tract physiology (HP:0012439)	2.27843323
40	Bile duct proliferation (HP:0001408)	2.27843323
41	Abnormal respiratory motile cilium physiology (HP:0012261)	2.25031149
42	Congenital primary aphakia (HP:0007707)	2.25011437
43	3-Methylglutaconic aciduria (HP:0003535)	2.24846838
44	Bony spicule pigmentary retinopathy (HP:0007737)	2.21050275
45	Lissencephaly (HP:0001339)	2.20448909
46	Inability to walk (HP:0002540)	2.19569451
47	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.17777589
48	Renal cortical cysts (HP:0000803)	2.17531797
49	Polydipsia (HP:0001959)	2.17030610
50	Abnormal drinking behavior (HP:0030082)	2.17030610
51	Keratoconus (HP:0000563)	2.16001416
52	Increased corneal curvature (HP:0100692)	2.16001416
53	Concave nail (HP:0001598)	2.14965832
54	Anencephaly (HP:0002323)	2.11759775
55	Tubular atrophy (HP:0000092)	2.06790963
56	Severe muscular hypotonia (HP:0006829)	2.06009278
57	Chorioretinal atrophy (HP:0000533)	2.05743003
58	Lipid accumulation in hepatocytes (HP:0006561)	2.05712551
59	Male pseudohermaphroditism (HP:0000037)	2.04715534
60	Methylmalonic aciduria (HP:0012120)	2.04351296
61	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.03506611
62	Clumsiness (HP:0002312)	2.02669325
63	Nephrogenic diabetes insipidus (HP:0009806)	2.02431458
64	Congenital sensorineural hearing impairment (HP:0008527)	1.99823916
65	Optic disc pallor (HP:0000543)	1.98913513
66	Abnormality of the pons (HP:0007361)	1.98041115
67	Genetic anticipation (HP:0003743)	1.97990027
68	Birth length less than 3rd percentile (HP:0003561)	1.97182964
69	Hypoplasia of the pons (HP:0012110)	1.97070570
70	Progressive cerebellar ataxia (HP:0002073)	1.95650310
71	Pachygyria (HP:0001302)	1.95004477
72	Hepatocellular necrosis (HP:0001404)	1.94945692
73	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.94158323
74	Hepatic necrosis (HP:0002605)	1.89947460
75	Gaze-evoked nystagmus (HP:0000640)	1.89273018
76	Stomach cancer (HP:0012126)	1.89201715
77	Hyperglycinemia (HP:0002154)	1.88894044
78	Fair hair (HP:0002286)	1.88432533
79	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.88399669
80	Congenital hepatic fibrosis (HP:0002612)	1.88368689
81	Aplasia/hypoplasia of the uterus (HP:0008684)	1.88311331
82	Occipital encephalocele (HP:0002085)	1.88011480
83	Broad-based gait (HP:0002136)	1.86562826
84	Absent speech (HP:0001344)	1.86501971
85	Polyuria (HP:0000103)	1.86306816
86	Furrowed tongue (HP:0000221)	1.84320387
87	Increased serum lactate (HP:0002151)	1.82054287
88	Genital tract atresia (HP:0001827)	1.80454409
89	Protruding tongue (HP:0010808)	1.80318904
90	Abnormality of the renal collecting system (HP:0004742)	1.80272022
91	Vaginal atresia (HP:0000148)	1.79757123
92	Hypothermia (HP:0002045)	1.78094931
93	Postaxial foot polydactyly (HP:0001830)	1.77622726
94	Large for gestational age (HP:0001520)	1.77330711
95	Retinitis pigmentosa (HP:0000510)	1.75459822
96	Decreased central vision (HP:0007663)	1.74632920
97	Absent thumb (HP:0009777)	1.74566136
98	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.74328466
99	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.73425681
100	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.71328465

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.77503371
2	ZAK	3.57249818
3	ADRBK2	3.51605912
4	TLK1	3.11803750
5	INSRR	2.87696471
6	MAP4K2	2.85177275
7	GRK1	2.79055403
8	BMPR1B	2.76610949
9	TAOK3	2.67761100
10	PINK1	2.56225355
11	NUAK1	2.43438647
12	WNK3	2.36078966
13	ACVR1B	2.33716631
14	WNK4	2.29271852
15	MAP3K4	2.23857660
16	MAP2K7	1.95383785
17	TXK	1.94466769
18	MAPK13	1.92584400
19	CASK	1.83116821
20	OXSR1	1.63188762
21	MARK1	1.41639600
22	PLK4	1.35024123
23	CDK19	1.31254803
24	CAMKK2	1.26960044
25	DAPK2	1.17882111
26	VRK1	1.08752008
27	MKNK2	1.06822462
28	TGFBR1	1.01169734
29	DYRK2	1.00603610
30	GRK7	0.94644385
31	ADRBK1	0.93059429
32	NTRK3	0.91552794
33	PRKCG	0.90321096
34	TNIK	0.89159852
35	BCKDK	0.86613661
36	PLK2	0.86045730
37	RPS6KA5	0.85500486
38	STK39	0.85463039
39	CSNK1G3	0.84770530
40	NTRK2	0.84065506
41	PNCK	0.81263340
42	TRIM28	0.80967710
43	PDK2	0.78963556
44	CSNK1G1	0.76025313
45	CSNK1G2	0.75969387
46	MAPK15	0.74737812
47	IKBKB	0.74716311
48	NEK2	0.73253141
49	MAPKAPK3	0.71016733
50	NME1	0.70682757
51	PRKCE	0.64827913
52	MUSK	0.64568402
53	PKN1	0.64048907
54	CSNK1A1L	0.63675845
55	PAK3	0.60337560
56	DYRK3	0.59588840
57	MAP2K1	0.55217547
58	KIT	0.54518116
59	CSNK1A1	0.53856501
60	STK16	0.53493710
61	BRSK2	0.52772334
62	ERBB3	0.52095206
63	MAPKAPK5	0.51952294
64	PLK1	0.51457545
65	CDC7	0.49251401
66	PRKCI	0.48553304
67	PRKCQ	0.47722682
68	PHKG2	0.47549487
69	PHKG1	0.47549487
70	CDK3	0.47353737
71	PRKACA	0.47073720
72	CAMK2A	0.44932797
73	STK3	0.44083045
74	TNK2	0.43164295
75	MAP2K6	0.40428344
76	MST4	0.39440095
77	VRK2	0.38625341
78	STK38L	0.38518265
79	MKNK1	0.38049274
80	* ATR	0.37752195
81	OBSCN	0.37412870
82	LYN	0.36469949
83	PIK3CA	0.35915451
84	TEC	0.35041860
85	PLK3	0.34907951
86	PRKG1	0.34789249
87	TIE1	0.34129539
88	CHEK2	0.33857645
89	AURKA	0.33482072
90	PRKCA	0.33066483
91	CSNK2A1	0.32926106
92	PTK2B	0.32077579
93	SYK	0.31043395
94	PRKAA1	0.30852814
95	SIK2	0.30738100
96	MAP2K4	0.29464782
97	EPHA3	0.28813514
98	IGF1R	0.28305627
99	PRKAA2	0.27106489
100	MAP2K2	0.26123492

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	2.81302216
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.57655029
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.52591708
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.43037225
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.38120735
6	RNA polymerase_Homo sapiens_hsa03020	2.30567361
7	Butanoate metabolism_Homo sapiens_hsa00650	2.29220139
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.22549983
9	Phototransduction_Homo sapiens_hsa04744	2.22415237
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.19181166
11	Parkinsons disease_Homo sapiens_hsa05012	2.17669420
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.04936427
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.04110467
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.94722729
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.87519329
16	Homologous recombination_Homo sapiens_hsa03440	1.86183136
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.85189536
18	Nicotine addiction_Homo sapiens_hsa05033	1.81437538
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.77899304
20	Basal transcription factors_Homo sapiens_hsa03022	1.76911589
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.65483591
22	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.64728108
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.58123689
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.55267421
25	Huntingtons disease_Homo sapiens_hsa05016	1.55016183
26	Protein export_Homo sapiens_hsa03060	1.52063774
27	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.42316991
28	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.41113568
29	Alzheimers disease_Homo sapiens_hsa05010	1.40532735
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.40361525
31	Peroxisome_Homo sapiens_hsa04146	1.40321080
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.38098676
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.36579235
34	RNA degradation_Homo sapiens_hsa03018	1.35465194
35	Sulfur metabolism_Homo sapiens_hsa00920	1.31543053
36	Olfactory transduction_Homo sapiens_hsa04740	1.27620662
37	Ribosome_Homo sapiens_hsa03010	1.26931122
38	Taste transduction_Homo sapiens_hsa04742	1.23627459
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.22545058
40	Proteasome_Homo sapiens_hsa03050	1.21658128
41	Caffeine metabolism_Homo sapiens_hsa00232	1.17547715
42	Chemical carcinogenesis_Homo sapiens_hsa05204	1.16241868
43	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.15412950
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.12447135
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.12187754
46	ABC transporters_Homo sapiens_hsa02010	1.09374510
47	Regulation of autophagy_Homo sapiens_hsa04140	1.09283886
48	Propanoate metabolism_Homo sapiens_hsa00640	1.04235249
49	Collecting duct acid secretion_Homo sapiens_hsa04966	1.03110334
50	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.02977031
51	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.01540420
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99429295
53	Asthma_Homo sapiens_hsa05310	0.98971479
54	Morphine addiction_Homo sapiens_hsa05032	0.92248364
55	Retinol metabolism_Homo sapiens_hsa00830	0.89781102
56	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.87470357
57	Pyrimidine metabolism_Homo sapiens_hsa00240	0.86013648
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.84546109
59	Purine metabolism_Homo sapiens_hsa00230	0.83938535
60	Steroid biosynthesis_Homo sapiens_hsa00100	0.80829746
61	One carbon pool by folate_Homo sapiens_hsa00670	0.80775679
62	Sulfur relay system_Homo sapiens_hsa04122	0.79656926
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.78154673
64	Metabolic pathways_Homo sapiens_hsa01100	0.72810682
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.68846835
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.66958325
67	GABAergic synapse_Homo sapiens_hsa04727	0.64680684
68	Serotonergic synapse_Homo sapiens_hsa04726	0.64170057
69	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.62810480
70	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.62590604
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61357961
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.60175957
73	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.59558161
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.58936353
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.58320733
76	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.57640756
77	Primary immunodeficiency_Homo sapiens_hsa05340	0.56032686
78	Fatty acid degradation_Homo sapiens_hsa00071	0.54712231
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.54522891
80	Rheumatoid arthritis_Homo sapiens_hsa05323	0.51237173
81	Insulin secretion_Homo sapiens_hsa04911	0.50831844
82	Base excision repair_Homo sapiens_hsa03410	0.48001940
83	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.46188253
84	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.46026178
85	Circadian entrainment_Homo sapiens_hsa04713	0.45992067
86	Nucleotide excision repair_Homo sapiens_hsa03420	0.44518109
87	Glutamatergic synapse_Homo sapiens_hsa04724	0.44058597
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43047907
89	Type I diabetes mellitus_Homo sapiens_hsa04940	0.41624697
90	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.41580630
91	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39637964
92	RNA transport_Homo sapiens_hsa03013	0.39448345
93	Histidine metabolism_Homo sapiens_hsa00340	0.38788153
94	Allograft rejection_Homo sapiens_hsa05330	0.38135001
95	Calcium signaling pathway_Homo sapiens_hsa04020	0.37488875
96	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.36960213
97	Graft-versus-host disease_Homo sapiens_hsa05332	0.35586059
98	Fatty acid metabolism_Homo sapiens_hsa01212	0.35341951
99	Salivary secretion_Homo sapiens_hsa04970	0.32541600
100	Glutathione metabolism_Homo sapiens_hsa00480	0.31504142

ZSCAN5A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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