ZSCAN9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)8.03379955
2nucleobase catabolic process (GO:0046113)6.26170389
3positive regulation of mitochondrial fission (GO:0090141)4.18647601
4establishment of mitochondrion localization (GO:0051654)4.15141066
5sequestering of actin monomers (GO:0042989)4.05709767
6pyrimidine dimer repair (GO:0006290)3.97869836
7limb bud formation (GO:0060174)3.77586749
8neurofilament cytoskeleton organization (GO:0060052)3.74638278
9neural tube formation (GO:0001841)3.69287741
10sympathetic nervous system development (GO:0048485)3.58537004
11nonmotile primary cilium assembly (GO:0035058)3.57763804
12intraciliary transport (GO:0042073)3.53799753
13microtubule depolymerization (GO:0007019)3.41798631
14head development (GO:0060322)3.40853446
15ribonucleoprotein complex disassembly (GO:0032988)3.33452764
16cell migration in hindbrain (GO:0021535)3.26740001
17protein polyglutamylation (GO:0018095)3.26460798
18mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.20558235
19positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.20558235
20olfactory bulb development (GO:0021772)3.18678242
21DNA integration (GO:0015074)3.16587252
22organelle disassembly (GO:1903008)3.16044988
23cerebral cortex radially oriented cell migration (GO:0021799)3.14234976
24protein localization to synapse (GO:0035418)3.13322793
25single strand break repair (GO:0000012)3.11052019
26cullin deneddylation (GO:0010388)3.08787492
27behavioral response to nicotine (GO:0035095)3.07223562
28ganglion development (GO:0061548)3.06924615
29cornea development in camera-type eye (GO:0061303)3.02744245
30centriole replication (GO:0007099)3.01188229
31protein-cofactor linkage (GO:0018065)2.98179500
32retinal ganglion cell axon guidance (GO:0031290)2.96940007
33hippocampus development (GO:0021766)2.91684388
34positive regulation of male gonad development (GO:2000020)2.90542575
35acrosome reaction (GO:0007340)2.90164535
36central nervous system projection neuron axonogenesis (GO:0021952)2.89096105
37establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.88560826
38mitochondrion transport along microtubule (GO:0047497)2.88560826
39negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.85717871
40regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.84608873
41regulation of development, heterochronic (GO:0040034)2.83962477
42spinal cord development (GO:0021510)2.83280663
43axonal fasciculation (GO:0007413)2.81901154
44acrosome assembly (GO:0001675)2.80299637
45resolution of meiotic recombination intermediates (GO:0000712)2.77720362
46regulation of male gonad development (GO:2000018)2.72499409
47anterograde axon cargo transport (GO:0008089)2.71385988
48regulation of mitotic spindle checkpoint (GO:1903504)2.71366886
49regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.71366886
50somite rostral/caudal axis specification (GO:0032525)2.70694427
51regulation of cilium movement (GO:0003352)2.70659318
52regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.69562362
53spermatid nucleus differentiation (GO:0007289)2.68193027
54protein deneddylation (GO:0000338)2.68150346
55somite development (GO:0061053)2.65573907
56cerebral cortex neuron differentiation (GO:0021895)2.62906552
57calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.62503077
58histone H2B ubiquitination (GO:0033523)2.62423892
59cytoskeleton-dependent intracellular transport (GO:0030705)2.61192301
60protein localization to cilium (GO:0061512)2.59591873
61ubiquinone metabolic process (GO:0006743)2.59051884
62spinal cord association neuron differentiation (GO:0021527)2.55897010
63negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.55290114
64cerebral cortex cell migration (GO:0021795)2.54619482
65microtubule polymerization or depolymerization (GO:0031109)2.53594639
66histone H3-K9 methylation (GO:0051567)2.53455170
67protein insertion into membrane (GO:0051205)2.51828128
68negative regulation of transcription regulatory region DNA binding (GO:2000678)2.51720391
69RNA localization (GO:0006403)2.51500311
70DNA double-strand break processing (GO:0000729)2.50534630
71negative regulation of oligodendrocyte differentiation (GO:0048715)2.49001771
72cell differentiation in spinal cord (GO:0021515)2.48220437
73histone H2A acetylation (GO:0043968)2.47615695
74RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.47587092
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.47587092
76regulation of mRNA splicing, via spliceosome (GO:0048024)2.46742287
77central nervous system neuron axonogenesis (GO:0021955)2.46171515
78microtubule-based transport (GO:0010970)2.45318517
79cardiac right ventricle morphogenesis (GO:0003215)2.44771102
80neuron recognition (GO:0008038)2.44572835
81lens morphogenesis in camera-type eye (GO:0002089)2.43138057
82glial cell proliferation (GO:0014009)2.43020101
83regulation of mitochondrial fission (GO:0090140)2.42531981
84regulation of timing of cell differentiation (GO:0048505)2.41993551
85cell fate commitment involved in formation of primary germ layer (GO:0060795)2.40733554
86seminiferous tubule development (GO:0072520)2.40236071
87anterograde synaptic vesicle transport (GO:0048490)2.36700907
88DNA damage response, detection of DNA damage (GO:0042769)2.36234712
89dosage compensation (GO:0007549)2.35653631
90mRNA splice site selection (GO:0006376)2.35327720
91regulation of centriole replication (GO:0046599)2.35008333
92regulation of feeding behavior (GO:0060259)2.34265649
93stress granule assembly (GO:0034063)2.33852245
94brain morphogenesis (GO:0048854)2.33848779
95protein K48-linked ubiquitination (GO:0070936)2.32750005
96de novo posttranslational protein folding (GO:0051084)2.30932410
97pancreas development (GO:0031016)2.29673859
98epithelial cell differentiation involved in kidney development (GO:0035850)2.27821910
99regulation of cAMP-dependent protein kinase activity (GO:2000479)2.23996953
100glycosphingolipid biosynthetic process (GO:0006688)2.23012738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.69340428
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.33846424
3EZH2_22144423_ChIP-Seq_EOC_Human3.94532656
4ZNF274_21170338_ChIP-Seq_K562_Hela3.34272659
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.70408983
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67632778
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.66558862
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66077571
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.60013005
10IGF1R_20145208_ChIP-Seq_DFB_Human2.42644035
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.39143457
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.35215468
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.24382551
14GBX2_23144817_ChIP-Seq_PC3_Human2.20430343
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.18853917
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18370569
17IRF1_19129219_ChIP-ChIP_H3396_Human2.16717695
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.11411072
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.09912561
20FUS_26573619_Chip-Seq_HEK293_Human2.04460186
21TAF15_26573619_Chip-Seq_HEK293_Human1.96138639
22EWS_26573619_Chip-Seq_HEK293_Human1.91488062
23RNF2_27304074_Chip-Seq_NSC_Mouse1.87114505
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.83800743
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82725464
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81873330
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81640129
28ELK1_19687146_ChIP-ChIP_HELA_Human1.80194785
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.78343358
30VDR_22108803_ChIP-Seq_LS180_Human1.77446343
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76053131
32VDR_23849224_ChIP-Seq_CD4+_Human1.63039163
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59489275
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59459304
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58674368
36SOX2_16153702_ChIP-ChIP_HESCs_Human1.55916258
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51830032
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46594953
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.44518175
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44159397
41GABP_19822575_ChIP-Seq_HepG2_Human1.41920770
42MYC_18940864_ChIP-ChIP_HL60_Human1.41897343
43P300_19829295_ChIP-Seq_ESCs_Human1.40680027
44CBP_20019798_ChIP-Seq_JUKART_Human1.39265325
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39265325
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31261637
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29041269
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29022083
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.26912742
50REST_21632747_ChIP-Seq_MESCs_Mouse1.26311180
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23105263
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22172625
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22112257
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20734097
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20661387
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18948153
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18886441
58TP53_22573176_ChIP-Seq_HFKS_Human1.18253088
59DCP1A_22483619_ChIP-Seq_HELA_Human1.17752586
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17340653
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16491612
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14114015
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14101837
64TTF2_22483619_ChIP-Seq_HELA_Human1.12694518
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10196928
66XRN2_22483619_ChIP-Seq_HELA_Human1.08707294
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.07968951
68ER_23166858_ChIP-Seq_MCF-7_Human1.07192176
69FOXP3_21729870_ChIP-Seq_TREG_Human1.07188920
70RUNX2_22187159_ChIP-Seq_PCA_Human1.06699968
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06484256
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06476991
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05516064
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05368798
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05303328
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04872217
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.03393682
78EED_16625203_ChIP-ChIP_MESCs_Mouse1.02808892
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02718690
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00546813
81CIITA_25753668_ChIP-Seq_RAJI_Human1.00191740
82YY1_21170310_ChIP-Seq_MESCs_Mouse0.99564816
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97579609
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96182626
85NANOG_16153702_ChIP-ChIP_HESCs_Human0.96159841
86SMAD4_21799915_ChIP-Seq_A2780_Human0.95015851
87NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94262014
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93755749
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93294946
90STAT3_23295773_ChIP-Seq_U87_Human0.92683431
91SMAD3_21741376_ChIP-Seq_EPCs_Human0.92037120
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90346021
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90346021
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90283727
95REST_19997604_ChIP-ChIP_NEURONS_Mouse0.89582230
96TAL1_26923725_Chip-Seq_HPCs_Mouse0.89076262
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88727598
98AR_25329375_ChIP-Seq_VCAP_Human0.87647791
99SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.87228749
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86050401

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.19793540
2MP0008789_abnormal_olfactory_epithelium3.19241280
3MP0005394_taste/olfaction_phenotype3.18018636
4MP0005499_abnormal_olfactory_system3.18018636
5MP0002102_abnormal_ear_morphology3.07786538
6MP0002822_catalepsy2.87063664
7MP0003121_genomic_imprinting2.65651596
8MP0003122_maternal_imprinting2.65621645
9MP0008995_early_reproductive_senescence2.65041707
10MP0008877_abnormal_DNA_methylation2.64582597
11MP0003890_abnormal_embryonic-extraembry2.54857747
12MP0000778_abnormal_nervous_system2.52775348
13MP0006276_abnormal_autonomic_nervous2.50580824
14MP0002653_abnormal_ependyma_morphology2.47127905
15MP0006292_abnormal_olfactory_placode2.38592778
16MP0001984_abnormal_olfaction2.19938704
17MP0003880_abnormal_central_pattern2.11533881
18MP0003787_abnormal_imprinting1.98335547
19MP0002751_abnormal_autonomic_nervous1.95340561
20MP0002638_abnormal_pupillary_reflex1.84719364
21MP0004133_heterotaxia1.78446772
22MP0008058_abnormal_DNA_repair1.66523862
23MP0004270_analgesia1.62717358
24MP0003123_paternal_imprinting1.57935641
25MP0000955_abnormal_spinal_cord1.55529457
26MP0003221_abnormal_cardiomyocyte_apopto1.52967452
27MP0001293_anophthalmia1.46547328
28MP0002184_abnormal_innervation1.46362884
29MP0000631_abnormal_neuroendocrine_gland1.43991413
30MP0005423_abnormal_somatic_nervous1.38170082
31MP0002233_abnormal_nose_morphology1.37712961
32MP0005253_abnormal_eye_physiology1.37648171
33MP0003119_abnormal_digestive_system1.36746317
34MP0003567_abnormal_fetal_cardiomyocyte1.35911185
35MP0006072_abnormal_retinal_apoptosis1.33002417
36MP0002234_abnormal_pharynx_morphology1.32727893
37MP0000049_abnormal_middle_ear1.31548356
38MP0002752_abnormal_somatic_nervous1.29778836
39MP0002938_white_spotting1.28652049
40MP0003786_premature_aging1.28497804
41MP0003861_abnormal_nervous_system1.26781345
42MP0004142_abnormal_muscle_tone1.24845830
43MP0002557_abnormal_social/conspecific_i1.22870775
44MP0002882_abnormal_neuron_morphology1.22243005
45MP0004811_abnormal_neuron_physiology1.21535483
46MP0004859_abnormal_synaptic_plasticity1.21338539
47MP0001286_abnormal_eye_development1.17298945
48MP0003938_abnormal_ear_development1.16557599
49MP0003937_abnormal_limbs/digits/tail_de1.15925362
50MP0002735_abnormal_chemical_nociception1.09444583
51MP0003942_abnormal_urinary_system1.09251855
52MP0005391_vision/eye_phenotype1.05834083
53MP0009046_muscle_twitch1.05478653
54MP0003698_abnormal_male_reproductive1.05104954
55MP0004147_increased_porphyrin_level1.03266937
56MP0002697_abnormal_eye_size1.03183724
57MP0003635_abnormal_synaptic_transmissio1.03012078
58MP0002152_abnormal_brain_morphology1.02873565
59MP0008932_abnormal_embryonic_tissue1.00060523
60MP0001929_abnormal_gametogenesis0.99785685
61MP0002063_abnormal_learning/memory/cond0.99742896
62MP0000537_abnormal_urethra_morphology0.99620775
63MP0000569_abnormal_digit_pigmentation0.99375783
64MP0003385_abnormal_body_wall0.98543040
65MP0005551_abnormal_eye_electrophysiolog0.98327817
66MP0002572_abnormal_emotion/affect_behav0.97746341
67MP0005410_abnormal_fertilization0.97099594
68MP0002210_abnormal_sex_determination0.96406702
69MP0001486_abnormal_startle_reflex0.94633519
70MP0001727_abnormal_embryo_implantation0.94626246
71MP0005386_behavior/neurological_phenoty0.94408667
72MP0004924_abnormal_behavior0.94408667
73MP0002067_abnormal_sensory_capabilities0.93685217
74MP0005195_abnormal_posterior_eye0.91625691
75MP0004197_abnormal_fetal_growth/weight/0.91116565
76MP0000647_abnormal_sebaceous_gland0.89870435
77MP0000026_abnormal_inner_ear0.88030662
78MP0002084_abnormal_developmental_patter0.85664915
79MP0001299_abnormal_eye_distance/0.85446319
80MP0000372_irregular_coat_pigmentation0.84034802
81MP0001188_hyperpigmentation0.83187337
82MP0003115_abnormal_respiratory_system0.83107662
83MP0000653_abnormal_sex_gland0.80609837
84MP0003315_abnormal_perineum_morphology0.80527465
85MP0004145_abnormal_muscle_electrophysio0.80338005
86MP0002272_abnormal_nervous_system0.80126705
87MP0009745_abnormal_behavioral_response0.79990629
88MP0003935_abnormal_craniofacial_develop0.79530579
89MP0001145_abnormal_male_reproductive0.78778688
90MP0001986_abnormal_taste_sensitivity0.76830159
91MP0003755_abnormal_palate_morphology0.76341561
92MP0005084_abnormal_gallbladder_morpholo0.75930933
93MP0002734_abnormal_mechanical_nocicepti0.75910709
94MP0004085_abnormal_heartbeat0.74703223
95MP0002081_perinatal_lethality0.74566097
96MP0005187_abnormal_penis_morphology0.73729095
97MP0005645_abnormal_hypothalamus_physiol0.73045087
98MP0004134_abnormal_chest_morphology0.72890949
99MP0006035_abnormal_mitochondrial_morpho0.72516235
100MP0009697_abnormal_copulation0.71359177

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)4.27536563
2Medial flaring of the eyebrow (HP:0010747)3.47459885
3Gait imbalance (HP:0002141)3.42328901
4Congenital primary aphakia (HP:0007707)3.26429148
5Lissencephaly (HP:0001339)3.15836322
6Nephrogenic diabetes insipidus (HP:0009806)3.14252043
7True hermaphroditism (HP:0010459)3.04001818
8Retinal dysplasia (HP:0007973)3.00279649
9Nephronophthisis (HP:0000090)2.97097295
10Hypoplasia of the brainstem (HP:0002365)2.94839404
11Aplasia/Hypoplasia of the brainstem (HP:0007362)2.94839404
12Amyotrophic lateral sclerosis (HP:0007354)2.90392674
13Tubulointerstitial nephritis (HP:0001970)2.85444812
14Atrophy/Degeneration involving motor neurons (HP:0007373)2.75546850
15Drooling (HP:0002307)2.72619389
16Chronic hepatic failure (HP:0100626)2.68709817
17Hyperglycinemia (HP:0002154)2.66723553
18Pachygyria (HP:0001302)2.65940462
19Vaginal atresia (HP:0000148)2.65240980
20Genital tract atresia (HP:0001827)2.65218006
21Polyphagia (HP:0002591)2.64118411
22Abnormality of the labia minora (HP:0012880)2.62697981
23Abnormality of the renal medulla (HP:0100957)2.59514443
24Degeneration of the lateral corticospinal tracts (HP:0002314)2.58762156
25Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.58762156
26Shoulder girdle muscle weakness (HP:0003547)2.57761672
27Abnormality of the corticospinal tract (HP:0002492)2.54816358
28Pancreatic cysts (HP:0001737)2.48426327
29Excessive salivation (HP:0003781)2.43164586
30Rimmed vacuoles (HP:0003805)2.41505742
31Pancreatic fibrosis (HP:0100732)2.40805264
32Agitation (HP:0000713)2.33082791
33Limb dystonia (HP:0002451)2.30488030
34Abnormality of the metopic suture (HP:0005556)2.27129037
35Abnormality of the musculature of the pelvis (HP:0001469)2.21826664
36Abnormality of the hip-girdle musculature (HP:0001445)2.21826664
37Abnormality of midbrain morphology (HP:0002418)2.21239682
38Molar tooth sign on MRI (HP:0002419)2.21239682
39Prominent metopic ridge (HP:0005487)2.15963837
40Oligodactyly (hands) (HP:0001180)2.14666623
41Urinary urgency (HP:0000012)2.12806508
42Poor coordination (HP:0002370)2.10594394
43Abnormality of the anterior horn cell (HP:0006802)2.10311442
44Degeneration of anterior horn cells (HP:0002398)2.10311442
45Male pseudohermaphroditism (HP:0000037)2.09605240
46Specific learning disability (HP:0001328)2.08635138
47Abnormality of DNA repair (HP:0003254)2.08585904
48Sclerocornea (HP:0000647)2.07612540
49Polymicrogyria (HP:0002126)2.06538725
50Micropenis (HP:0000054)1.99393580
51Postaxial foot polydactyly (HP:0001830)1.98467178
52Renal cortical cysts (HP:0000803)1.97922291
53Broad foot (HP:0001769)1.97114773
54Postaxial hand polydactyly (HP:0001162)1.95537366
55Poor suck (HP:0002033)1.95470442
56Scrotal hypoplasia (HP:0000046)1.94918893
57Anophthalmia (HP:0000528)1.92840373
58Papillary thyroid carcinoma (HP:0002895)1.92217142
59Growth hormone deficiency (HP:0000824)1.87603753
60Aplasia/Hypoplasia of the lens (HP:0008063)1.85243010
61Hepatoblastoma (HP:0002884)1.85109346
62Decreased testicular size (HP:0008734)1.84816581
63Type II lissencephaly (HP:0007260)1.84179294
64Pendular nystagmus (HP:0012043)1.81830305
65Gonadotropin excess (HP:0000837)1.80490920
66Optic nerve hypoplasia (HP:0000609)1.79891567
67Broad-based gait (HP:0002136)1.78507772
68Thyroid carcinoma (HP:0002890)1.77156616
69Hip dysplasia (HP:0001385)1.76733409
70Hypothermia (HP:0002045)1.76275925
71Morphological abnormality of the pyramidal tract (HP:0002062)1.75886752
72Intellectual disability, moderate (HP:0002342)1.75774790
73Abnormality of the intervertebral disk (HP:0005108)1.75212048
74Hemivertebrae (HP:0002937)1.73907197
75Progressive cerebellar ataxia (HP:0002073)1.73112871
76Patellar aplasia (HP:0006443)1.73026465
77Bile duct proliferation (HP:0001408)1.72801433
78Abnormal biliary tract physiology (HP:0012439)1.72801433
79Failure to thrive in infancy (HP:0001531)1.72489840
80Spastic tetraplegia (HP:0002510)1.71796382
81Aplasia/Hypoplasia of the uvula (HP:0010293)1.71118976
82Aplasia/Hypoplasia of the sternum (HP:0006714)1.70742191
83Optic nerve coloboma (HP:0000588)1.69989777
84Atonic seizures (HP:0010819)1.68772609
85Pelvic girdle muscle weakness (HP:0003749)1.68650846
86Abnormality of the renal cortex (HP:0011035)1.68223179
87Anencephaly (HP:0002323)1.67877064
88Hypsarrhythmia (HP:0002521)1.67372630
89Astigmatism (HP:0000483)1.66075787
90Tubulointerstitial abnormality (HP:0001969)1.65682115
91Aganglionic megacolon (HP:0002251)1.63786061
92Narrow forehead (HP:0000341)1.62862516
93Meckel diverticulum (HP:0002245)1.62572888
94Aplasia/Hypoplasia of the tongue (HP:0010295)1.61532073
95Esotropia (HP:0000565)1.61147976
96Dandy-Walker malformation (HP:0001305)1.59758853
97Impaired vibration sensation in the lower limbs (HP:0002166)1.59405706
98Preaxial hand polydactyly (HP:0001177)1.59385466
99Adrenal hypoplasia (HP:0000835)1.58716076
100Entropion (HP:0000621)1.58237889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.94604438
2MAP3K43.98173164
3MARK13.93268664
4MAP2K73.33775034
5BCR2.99617381
6SRPK12.94678945
7ERBB32.62744956
8DYRK22.50768970
9WNK32.45290605
10MAPK132.30856736
11TRIM282.29049008
12DYRK31.98611394
13EIF2AK31.97156456
14CDK191.91438821
15BCKDK1.82948450
16PLK41.81416993
17CSNK1A1L1.72465218
18CSNK1G31.71502585
19MAP2K41.59760832
20CSNK1G21.54218284
21EPHA41.51947320
22DYRK1B1.49002915
23CSNK1G11.45768112
24BMPR1B1.43295047
25CASK1.41959468
26LATS11.25072364
27BRD41.20103321
28PINK11.18453288
29ZAK1.18345840
30NUAK11.15573735
31MAP3K61.12193684
32MKNK11.08867470
33PAK31.08330276
34DYRK1A1.05740795
35SIK20.94221536
36MATK0.91216024
37KSR10.87241848
38TSSK60.82151364
39MKNK20.81899912
40PLK20.76861286
41NEK20.75390613
42RPS6KA40.70022199
43EPHA30.69188832
44TGFBR10.67606124
45ATR0.65162251
46TESK20.62277228
47EPHB20.60521208
48CDC70.59605549
49PLK10.59053853
50VRK10.57076953
51CDK140.56605251
52ATM0.56539850
53CDK180.56310917
54CDK11A0.55596558
55MINK10.55376319
56CDK50.53969690
57CDK30.53586940
58PRKACB0.53079509
59PRKAA10.51677808
60PRKCG0.51602721
61PRKCE0.51052052
62CDK150.50806974
63PNCK0.50091648
64FLT30.49642789
65RPS6KA50.47958859
66ICK0.47441096
67INSRR0.47239071
68MAPK150.47081247
69MAP3K50.46950866
70PKN10.45451787
71AKT30.45297111
72EIF2AK10.44986710
73SIK30.44865265
74ACVR1B0.43443969
75NEK10.43365343
76CLK10.42588033
77PHKG10.42464655
78PHKG20.42464655
79WEE10.42244079
80CSNK1D0.42048826
81CSNK1E0.41657878
82GRK70.41306133
83IRAK20.41200001
84UHMK10.40577589
85CSNK1A10.39877218
86AURKA0.39606849
87CDK20.39200192
88NME10.37587504
89PLK30.37142333
90ADRBK20.35622806
91ADRBK10.34920782
92CCNB10.34902241
93STK38L0.34431150
94NTRK10.32633088
95CDK10.32085416
96PRKCZ0.31935611
97NEK90.30869756
98GRK10.30639797
99OXSR10.29787293
100TLK10.29746614

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030223.03089241
2Steroid biosynthesis_Homo sapiens_hsa001003.02683888
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45799390
4Protein export_Homo sapiens_hsa030602.42238707
5Nicotine addiction_Homo sapiens_hsa050332.41137859
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.37773459
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.29738836
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20461213
9Fanconi anemia pathway_Homo sapiens_hsa034602.16662146
10Phototransduction_Homo sapiens_hsa047442.10237827
11RNA polymerase_Homo sapiens_hsa030201.99898804
12RNA degradation_Homo sapiens_hsa030181.99546069
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89709973
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.89509976
15Fatty acid elongation_Homo sapiens_hsa000621.89018193
16RNA transport_Homo sapiens_hsa030131.85655658
17Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.84658172
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80540951
19Propanoate metabolism_Homo sapiens_hsa006401.73963376
20Spliceosome_Homo sapiens_hsa030401.67273711
21mRNA surveillance pathway_Homo sapiens_hsa030151.66593385
22Butanoate metabolism_Homo sapiens_hsa006501.64462902
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.63611401
24Oxidative phosphorylation_Homo sapiens_hsa001901.60974075
25Parkinsons disease_Homo sapiens_hsa050121.60907734
26Axon guidance_Homo sapiens_hsa043601.58759459
27GABAergic synapse_Homo sapiens_hsa047271.57210323
28Base excision repair_Homo sapiens_hsa034101.53374587
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36617369
30Nucleotide excision repair_Homo sapiens_hsa034201.34292539
31Selenocompound metabolism_Homo sapiens_hsa004501.33288150
32Non-homologous end-joining_Homo sapiens_hsa034501.32949434
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28698062
34Regulation of autophagy_Homo sapiens_hsa041401.28026079
35Huntingtons disease_Homo sapiens_hsa050161.24597923
36Olfactory transduction_Homo sapiens_hsa047401.12383801
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10310184
38Synaptic vesicle cycle_Homo sapiens_hsa047211.10253761
39Collecting duct acid secretion_Homo sapiens_hsa049661.10057536
40Morphine addiction_Homo sapiens_hsa050321.09093114
41Taste transduction_Homo sapiens_hsa047421.07112857
42Ether lipid metabolism_Homo sapiens_hsa005651.05501723
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05229402
44Mismatch repair_Homo sapiens_hsa034301.03045107
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00058437
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99602156
47Dopaminergic synapse_Homo sapiens_hsa047280.98860626
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98440196
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97963255
50Cardiac muscle contraction_Homo sapiens_hsa042600.97083826
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90067173
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88572758
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88127177
54Oocyte meiosis_Homo sapiens_hsa041140.87532142
55Alcoholism_Homo sapiens_hsa050340.85303192
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.84992930
57Circadian rhythm_Homo sapiens_hsa047100.84858424
58Cell cycle_Homo sapiens_hsa041100.81203220
59Linoleic acid metabolism_Homo sapiens_hsa005910.80563194
60Pyrimidine metabolism_Homo sapiens_hsa002400.80340731
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79946747
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75816155
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74760351
64Peroxisome_Homo sapiens_hsa041460.74130230
65Purine metabolism_Homo sapiens_hsa002300.73979965
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73424527
67Glutamatergic synapse_Homo sapiens_hsa047240.73240618
68Fatty acid metabolism_Homo sapiens_hsa012120.72528846
69Alzheimers disease_Homo sapiens_hsa050100.70811213
70Serotonergic synapse_Homo sapiens_hsa047260.68340044
71Cocaine addiction_Homo sapiens_hsa050300.61623113
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59432290
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58375003
74Metabolic pathways_Homo sapiens_hsa011000.57404221
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57067204
76Hippo signaling pathway_Homo sapiens_hsa043900.56543467
77Long-term depression_Homo sapiens_hsa047300.56049990
78Hedgehog signaling pathway_Homo sapiens_hsa043400.54086712
79Vibrio cholerae infection_Homo sapiens_hsa051100.53984908
80Biosynthesis of amino acids_Homo sapiens_hsa012300.52939077
81Ovarian steroidogenesis_Homo sapiens_hsa049130.52536287
82Proteasome_Homo sapiens_hsa030500.52250551
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52248594
84TGF-beta signaling pathway_Homo sapiens_hsa043500.51412125
85Arginine and proline metabolism_Homo sapiens_hsa003300.51163703
86Gap junction_Homo sapiens_hsa045400.50446239
87Circadian entrainment_Homo sapiens_hsa047130.50223439
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49450971
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49108886
90p53 signaling pathway_Homo sapiens_hsa041150.47108225
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.45463995
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44894774
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44184750
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42430850
95Basal cell carcinoma_Homo sapiens_hsa052170.41180842
96Cholinergic synapse_Homo sapiens_hsa047250.41058227
97Pyruvate metabolism_Homo sapiens_hsa006200.40893837
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38052308
99Sulfur metabolism_Homo sapiens_hsa009200.32851854
100Wnt signaling pathway_Homo sapiens_hsa043100.32394763

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