ZSWIM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.40975779
2serotonin metabolic process (GO:0042428)6.17222163
3alkaloid metabolic process (GO:0009820)6.03876818
4indolalkylamine metabolic process (GO:0006586)5.85199966
5primary amino compound metabolic process (GO:1901160)5.47536264
6dopamine biosynthetic process (GO:0042416)5.06888120
7response to insecticide (GO:0017085)4.82568477
8DNA replication checkpoint (GO:0000076)4.71948470
9DNA deamination (GO:0045006)4.66381834
10nucleobase biosynthetic process (GO:0046112)4.61345569
11purine nucleobase biosynthetic process (GO:0009113)4.52497131
12water-soluble vitamin biosynthetic process (GO:0042364)4.50752281
13mitotic metaphase plate congression (GO:0007080)4.45647447
14indole-containing compound metabolic process (GO:0042430)4.36100248
15toxin metabolic process (GO:0009404)4.29693603
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.27165229
17formation of translation preinitiation complex (GO:0001731)4.26831173
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.26577233
19sulfation (GO:0051923)4.18021738
20ribosome biogenesis (GO:0042254)4.14161349
21DNA strand elongation involved in DNA replication (GO:0006271)4.13781855
22regulation of posttranscriptional gene silencing (GO:0060147)3.95438653
23regulation of gene silencing by miRNA (GO:0060964)3.95438653
24regulation of gene silencing by RNA (GO:0060966)3.95438653
25cullin deneddylation (GO:0010388)3.95390806
26DNA replication initiation (GO:0006270)3.94594350
27DNA strand elongation (GO:0022616)3.89237567
28detection of light stimulus involved in visual perception (GO:0050908)3.86163700
29detection of light stimulus involved in sensory perception (GO:0050962)3.86163700
30protein deneddylation (GO:0000338)3.80319166
31ATP synthesis coupled proton transport (GO:0015986)3.78832518
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.78832518
33histone arginine methylation (GO:0034969)3.75583733
34telomere maintenance via semi-conservative replication (GO:0032201)3.73854336
35mitotic sister chromatid segregation (GO:0000070)3.73082540
36proteasome assembly (GO:0043248)3.69322979
37DNA replication-dependent nucleosome assembly (GO:0006335)3.66487097
38DNA replication-dependent nucleosome organization (GO:0034723)3.66487097
39kynurenine metabolic process (GO:0070189)3.65021700
40somatic hypermutation of immunoglobulin genes (GO:0016446)3.64947504
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.64947504
42metaphase plate congression (GO:0051310)3.58252452
43tryptophan catabolic process (GO:0006569)3.55058266
44indole-containing compound catabolic process (GO:0042436)3.55058266
45indolalkylamine catabolic process (GO:0046218)3.55058266
46hindbrain development (GO:0030902)3.53647867
47protein localization to kinetochore (GO:0034501)3.51547875
48maturation of 5.8S rRNA (GO:0000460)3.50262747
49histone H3-K9 methylation (GO:0051567)3.45809745
50mitotic nuclear envelope disassembly (GO:0007077)3.45100775
51RNA destabilization (GO:0050779)3.44347280
52protein-cofactor linkage (GO:0018065)3.44165802
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.44029397
54termination of RNA polymerase III transcription (GO:0006386)3.44029397
55regulation of hippo signaling (GO:0035330)3.42366088
56ribosome assembly (GO:0042255)3.41919099
57pseudouridine synthesis (GO:0001522)3.40555485
58postsynaptic membrane organization (GO:0001941)3.40237000
59spliceosomal snRNP assembly (GO:0000387)3.39555323
60rRNA modification (GO:0000154)3.39157878
61gamma-aminobutyric acid transport (GO:0015812)3.37545916
62peptidyl-arginine omega-N-methylation (GO:0035247)3.36945461
63opioid receptor signaling pathway (GO:0038003)3.36765542
64mitochondrial respiratory chain complex I assembly (GO:0032981)3.36502016
65NADH dehydrogenase complex assembly (GO:0010257)3.36502016
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.36502016
67cornea development in camera-type eye (GO:0061303)3.36434026
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35639708
69maturation of SSU-rRNA (GO:0030490)3.33368807
70catechol-containing compound biosynthetic process (GO:0009713)3.32964699
71catecholamine biosynthetic process (GO:0042423)3.32964699
72IMP biosynthetic process (GO:0006188)3.28152309
73establishment of chromosome localization (GO:0051303)3.28092014
74regulation of nuclear cell cycle DNA replication (GO:0033262)3.28037045
75negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.27579600
76regulation of action potential (GO:0098900)3.24933913
77cellular response to ATP (GO:0071318)3.24659610
78negative regulation of systemic arterial blood pressure (GO:0003085)3.24136583
79attachment of spindle microtubules to kinetochore (GO:0008608)3.23940423
80protein complex biogenesis (GO:0070271)3.22845154
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.22494754
82telomere maintenance via recombination (GO:0000722)3.22102694
83membrane disassembly (GO:0030397)3.21835243
84nuclear envelope disassembly (GO:0051081)3.21835243
857-methylguanosine mRNA capping (GO:0006370)3.20980098
86negative regulation of chromosome segregation (GO:0051985)3.20503555
87regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.20482958
88telomere maintenance via telomere lengthening (GO:0010833)3.19320477
89cell proliferation in forebrain (GO:0021846)3.18491675
90ribonucleoprotein complex biogenesis (GO:0022613)3.16233661
91regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.15813809
92somite development (GO:0061053)3.14553964
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.14418007
94negative regulation of transcription regulatory region DNA binding (GO:2000678)3.10370884
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09695633
96negative regulation of sister chromatid segregation (GO:0033046)3.09695633
97negative regulation of mitotic sister chromatid separation (GO:2000816)3.09695633
98negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09695633
99DNA unwinding involved in DNA replication (GO:0006268)3.09496159
100regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.09456984
101folic acid-containing compound biosynthetic process (GO:0009396)3.08786311
102RNA capping (GO:0036260)3.08152712
1037-methylguanosine RNA capping (GO:0009452)3.08152712
104transcription-coupled nucleotide-excision repair (GO:0006283)3.06719318
105mitotic spindle assembly checkpoint (GO:0007094)3.06598282
106nucleotide-excision repair, DNA gap filling (GO:0006297)3.04838074
107microtubule depolymerization (GO:0007019)3.04611207
108tryptophan metabolic process (GO:0006568)3.03526367
109negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02863084
110spindle assembly checkpoint (GO:0071173)3.02806062
111protein K6-linked ubiquitination (GO:0085020)3.02710590
112establishment of protein localization to mitochondrial membrane (GO:0090151)3.02379568
113histone H4-K12 acetylation (GO:0043983)3.00790272
114regulation of telomere maintenance via telomerase (GO:0032210)3.00208197
115regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.99579814
116platelet dense granule organization (GO:0060155)2.99186990
117regulation of chromosome segregation (GO:0051983)2.98876425
118L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.98192215
119L-fucose metabolic process (GO:0042354)2.96012634
120L-fucose catabolic process (GO:0042355)2.96012634
121fucose catabolic process (GO:0019317)2.96012634
122negative regulation of ligase activity (GO:0051352)2.95771201
123negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.95771201
124mitotic recombination (GO:0006312)2.95583032
125negative regulation of telomere maintenance (GO:0032205)2.95445798
126rRNA processing (GO:0006364)2.95421153
127GDP-mannose metabolic process (GO:0019673)2.94850645
128histone H2A acetylation (GO:0043968)2.94495009
129maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.94183144
130mitochondrial respiratory chain complex assembly (GO:0033108)2.93797743
131regulation of double-strand break repair via homologous recombination (GO:0010569)2.93744955
132protein localization to chromosome, centromeric region (GO:0071459)2.93034371
133negative regulation of mast cell activation (GO:0033004)2.91031613
134mitotic spindle checkpoint (GO:0071174)2.90747306
135sister chromatid segregation (GO:0000819)2.90743207
136positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.89743456
137postreplication repair (GO:0006301)2.89224509
138regulation of translation in response to stress (GO:0043555)2.89052713
139spindle checkpoint (GO:0031577)2.88288331
140nephron tubule morphogenesis (GO:0072078)2.88029932
141nephron epithelium morphogenesis (GO:0072088)2.88029932
142peptidyl-arginine N-methylation (GO:0035246)2.86834088
143peptidyl-arginine methylation (GO:0018216)2.86834088
144regulation of glomerulus development (GO:0090192)2.86476457
145peristalsis (GO:0030432)2.86177051
146rRNA metabolic process (GO:0016072)2.86096668
147positive regulation of fatty acid oxidation (GO:0046321)2.84911536
148replication fork processing (GO:0031297)2.84136651
149cell cycle G1/S phase transition (GO:0044843)2.84042978
150G1/S transition of mitotic cell cycle (GO:0000082)2.84042978
151positive regulation of chromosome segregation (GO:0051984)2.82606867
152neuronal action potential (GO:0019228)2.82516125
1533-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.81602890
154purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.81602890
155regulation of helicase activity (GO:0051095)2.80741151
156regulation of mitotic metaphase/anaphase transition (GO:0030071)2.80497998
157regulation of mitotic sister chromatid separation (GO:0010965)2.79884068
158regulation of mitotic sister chromatid segregation (GO:0033047)2.79884068
159regulation of sister chromatid segregation (GO:0033045)2.79884068
160response to UV-C (GO:0010225)2.77956488
161positive regulation of fatty acid beta-oxidation (GO:0032000)2.77691398
162epithelial cilium movement (GO:0003351)2.72886131
163cellular biogenic amine biosynthetic process (GO:0042401)2.69816483
164regulation of rhodopsin mediated signaling pathway (GO:0022400)2.69406610
165transepithelial transport (GO:0070633)2.63854710
166positive regulation of cAMP-mediated signaling (GO:0043950)2.59472654
167regulation of telomere maintenance (GO:0032204)2.57705345
168rhodopsin mediated signaling pathway (GO:0016056)2.57104874
169histone H3-K9 modification (GO:0061647)2.56644129
170multicellular organismal aging (GO:0010259)2.56456387
171response to pheromone (GO:0019236)2.55891029
172regulation of glucokinase activity (GO:0033131)2.55665332
173regulation of hexokinase activity (GO:1903299)2.55665332
174phasic smooth muscle contraction (GO:0014821)2.55221080
175amine biosynthetic process (GO:0009309)2.54727579
176regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.53494280
177positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.53494280
178protein polyglutamylation (GO:0018095)2.52448563
179negative regulation of synaptic transmission, GABAergic (GO:0032229)2.50448790
180negative regulation of axon guidance (GO:1902668)2.50291017
181flavonoid metabolic process (GO:0009812)2.44646896
182regulation of mesoderm development (GO:2000380)2.44526361
183positive regulation of metanephros development (GO:0072216)2.41308277
184pyrimidine nucleobase catabolic process (GO:0006208)2.40860217
185reflex (GO:0060004)2.40461285
186embryonic epithelial tube formation (GO:0001838)2.38824812
187spinal cord motor neuron differentiation (GO:0021522)2.38460159
188positive regulation of action potential (GO:0045760)2.37368635
189kidney morphogenesis (GO:0060993)2.36850902
190iron coordination entity transport (GO:1901678)2.35641602
191synaptic transmission, cholinergic (GO:0007271)2.33696812
192regulation of cell proliferation involved in kidney development (GO:1901722)2.33687760
193presynaptic membrane assembly (GO:0097105)2.33469683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.48688338
2EZH2_22144423_ChIP-Seq_EOC_Human5.19609662
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.55713071
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.94073405
5VDR_22108803_ChIP-Seq_LS180_Human3.85823535
6ZNF274_21170338_ChIP-Seq_K562_Hela3.59636468
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26214300
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.21754279
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.09268456
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.08681695
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04240498
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.01702967
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.00102074
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.99538200
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.97002337
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93975527
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88819491
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79738083
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.68975196
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.66144351
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65317336
22GBX2_23144817_ChIP-Seq_PC3_Human2.61303899
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58084537
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.49091790
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44220516
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39443718
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.38597657
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36468758
29NANOG_18555785_ChIP-Seq_MESCs_Mouse2.33237023
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.31238150
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23793837
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.22714224
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.21786931
34XRN2_22483619_ChIP-Seq_HELA_Human2.20766541
35CBX2_27304074_Chip-Seq_ESCs_Mouse2.19089841
36TAF15_26573619_Chip-Seq_HEK293_Human2.18182965
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.16357350
38VDR_23849224_ChIP-Seq_CD4+_Human2.12076708
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08204594
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06696967
41CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05593331
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.03860178
43GABP_19822575_ChIP-Seq_HepG2_Human2.01641334
44IGF1R_20145208_ChIP-Seq_DFB_Human1.99809544
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98805559
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.98775054
47EWS_26573619_Chip-Seq_HEK293_Human1.96768973
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.96711902
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96142204
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95909595
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95863912
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92973249
53FUS_26573619_Chip-Seq_HEK293_Human1.90784247
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90274835
55NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.85288271
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.79504014
57* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.78314668
58FOXP3_21729870_ChIP-Seq_TREG_Human1.77225666
59* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.76943574
60DCP1A_22483619_ChIP-Seq_HELA_Human1.76221307
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.75978221
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.75775894
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.73642157
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.73642157
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.73642157
66* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70068230
67TTF2_22483619_ChIP-Seq_HELA_Human1.67401146
68P300_19829295_ChIP-Seq_ESCs_Human1.65806617
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65191400
70ER_23166858_ChIP-Seq_MCF-7_Human1.62815802
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62692065
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61722462
73KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59306073
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58946445
75EZH2_27304074_Chip-Seq_ESCs_Mouse1.57981645
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57630596
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.57461235
78MYC_18940864_ChIP-ChIP_HL60_Human1.55812701
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54987983
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53155605
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52058561
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51917095
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50363055
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50096531
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.49457954
86REST_21632747_ChIP-Seq_MESCs_Mouse1.48419845
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47809979
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47568377
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45836790
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45673485
91RNF2_27304074_Chip-Seq_NSC_Mouse1.45467048
92KDM5A_27292631_Chip-Seq_BREAST_Human1.44063848
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43490979
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.42578536
95* SRF_21415370_ChIP-Seq_HL-1_Mouse1.42525823
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.42352904
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42107725
98STAT3_23295773_ChIP-Seq_U87_Human1.41411856
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40995045
100CIITA_25753668_ChIP-Seq_RAJI_Human1.40366545
101JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39436275
102SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38232389
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37661232
104EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37566200
105NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.37465945
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37442773
107AR_21909140_ChIP-Seq_LNCAP_Human1.37431746
108KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36634104
109TCF3_18692474_ChIP-Seq_MEFs_Mouse1.35085236
110SMAD4_21799915_ChIP-Seq_A2780_Human1.35076065
111* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34886593
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.34591461
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34537819
114* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34269871
115E2F1_21310950_ChIP-Seq_MCF-7_Human1.32758455
116BCAT_22108803_ChIP-Seq_LS180_Human1.32353165
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31967252
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31924888
119ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30806487
120NANOG_21062744_ChIP-ChIP_HESCs_Human1.29204106
121TP53_22573176_ChIP-Seq_HFKS_Human1.27164016
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26937919
123TCF4_23295773_ChIP-Seq_U87_Human1.26255428
124AR_25329375_ChIP-Seq_VCAP_Human1.25656870
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25633891
126CBP_20019798_ChIP-Seq_JUKART_Human1.25633891
127FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25570855
128AUTS2_25519132_ChIP-Seq_293T-REX_Human1.23388310
129TCF3_18692474_ChIP-Seq_MESCs_Mouse1.22803216
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22053071
131JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21444456
132* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.21407672
133SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21183402
134SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20854305
135* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20620435
136MYC_22102868_ChIP-Seq_BL_Human1.19808242
137RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19692199
138IRF1_19129219_ChIP-ChIP_H3396_Human1.18628530
139SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16650578
140FOXA1_25329375_ChIP-Seq_VCAP_Human1.15353029
141FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15353029
142PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14825201
143SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14205903
144* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13424847
145PRDM14_20953172_ChIP-Seq_ESCs_Human1.12712379
146EZH2_27294783_Chip-Seq_ESCs_Mouse1.12394637
147AR_21572438_ChIP-Seq_LNCaP_Human1.11086312
148NANOG_19829295_ChIP-Seq_ESCs_Human1.11011209
149SOX2_19829295_ChIP-Seq_ESCs_Human1.11011209
150PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09538956
151* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.09044178
152* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08535592
153CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08006994
154OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07386096
155RUNX2_22187159_ChIP-Seq_PCA_Human1.06560298
156ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06259495
157TFEB_21752829_ChIP-Seq_HELA_Human1.05893552
158TCF4_22108803_ChIP-Seq_LS180_Human1.05103857
159STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05064532
160SMAD4_21741376_ChIP-Seq_EPCs_Human1.04575277
161SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04483920
162FLI1_21867929_ChIP-Seq_TH2_Mouse1.02157350
163NANOG_18555785_Chip-Seq_ESCs_Mouse1.02063244
164RNF2_27304074_Chip-Seq_ESCs_Mouse1.02047137
165HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01771049
166BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01567620
167SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00799445
168E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00503518
169ELK1_19687146_ChIP-ChIP_HELA_Human1.00340678
170* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00081979
171ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99424540
172EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99211333
173TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98792155
174POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98792155
175CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98790067
176SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98537398
177CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98348450
178PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96674257
179TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96672529
180NFE2_27457419_Chip-Seq_LIVER_Mouse0.96589342
181HOXB7_26014856_ChIP-Seq_BT474_Human0.96297973
182ZNF263_19887448_ChIP-Seq_K562_Human0.96014535
183P53_22387025_ChIP-Seq_ESCs_Mouse0.95643748
184* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95017194
185POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94952413
186TDRD3_21172665_ChIP-Seq_MCF-7_Human0.94890092
187* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.94723636
188GATA3_21878914_ChIP-Seq_MCF-7_Human0.94721559
189SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94344174
190TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94181648
191NCOR_22424771_ChIP-Seq_293T_Human0.94049173
192CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94038482
193SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93847072
194* KAP1_27257070_Chip-Seq_ESCs_Mouse0.92718749
195FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92702185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.51663665
2MP0004957_abnormal_blastocyst_morpholog4.69923583
3MP0000569_abnormal_digit_pigmentation4.46309448
4MP0003111_abnormal_nucleus_morphology4.11613904
5MP0010094_abnormal_chromosome_stability4.09837481
6MP0002653_abnormal_ependyma_morphology3.85275523
7MP0008057_abnormal_DNA_replication3.61114194
8MP0003077_abnormal_cell_cycle3.55721657
9MP0005645_abnormal_hypothalamus_physiol3.07574485
10MP0008877_abnormal_DNA_methylation3.05411702
11MP0008058_abnormal_DNA_repair3.02771543
12MP0003195_calcinosis2.78610408
13MP0003123_paternal_imprinting2.65451322
14MP0008932_abnormal_embryonic_tissue2.61855965
15MP0003880_abnormal_central_pattern2.41760419
16MP0000631_abnormal_neuroendocrine_gland2.38127892
17MP0005423_abnormal_somatic_nervous2.36801798
18MP0001730_embryonic_growth_arrest2.30318119
19MP0006292_abnormal_olfactory_placode2.24442760
20MP0003787_abnormal_imprinting2.20959206
21MP0000350_abnormal_cell_proliferation2.14272673
22MP0003786_premature_aging2.13134143
23MP0008007_abnormal_cellular_replicative2.09731144
24MP0005551_abnormal_eye_electrophysiolog2.09657205
25MP0009745_abnormal_behavioral_response2.04236940
26MP0002272_abnormal_nervous_system2.03797791
27MP0003890_abnormal_embryonic-extraembry1.96125934
28MP0002876_abnormal_thyroid_physiology1.94758207
29MP0001968_abnormal_touch/_nociception1.94450397
30MP0002837_dystrophic_cardiac_calcinosis1.94142649
31MP0005646_abnormal_pituitary_gland1.85802612
32MP0003718_maternal_effect1.83523491
33MP0002102_abnormal_ear_morphology1.80808034
34MP0010352_gastrointestinal_tract_polyps1.77893829
35MP0004133_heterotaxia1.77058924
36MP0004885_abnormal_endolymph1.63746092
37MP0001485_abnormal_pinna_reflex1.63644881
38MP0001697_abnormal_embryo_size1.62642718
39MP0004145_abnormal_muscle_electrophysio1.62581597
40MP0001672_abnormal_embryogenesis/_devel1.61312397
41MP0005380_embryogenesis_phenotype1.61312397
42MP0002735_abnormal_chemical_nociception1.60856369
43MP0002638_abnormal_pupillary_reflex1.60152832
44MP0002210_abnormal_sex_determination1.59487120
45MP0001529_abnormal_vocalization1.59012545
46MP0003121_genomic_imprinting1.58229130
47MP0002085_abnormal_embryonic_tissue1.53971201
48MP0000049_abnormal_middle_ear1.51340629
49MP0002080_prenatal_lethality1.51178352
50MP0001929_abnormal_gametogenesis1.49024578
51MP0002084_abnormal_developmental_patter1.48708638
52MP0001145_abnormal_male_reproductive1.45409420
53MP0002938_white_spotting1.44848735
54MP0004233_abnormal_muscle_weight1.40647965
55MP0006035_abnormal_mitochondrial_morpho1.40401087
56MP0004742_abnormal_vestibular_system1.37025758
57MP0002184_abnormal_innervation1.36775743
58MP0003119_abnormal_digestive_system1.33605005
59MP0003984_embryonic_growth_retardation1.30841382
60MP0001970_abnormal_pain_threshold1.29823659
61MP0002088_abnormal_embryonic_growth/wei1.27434294
62MP0003122_maternal_imprinting1.27411097
63MP0008875_abnormal_xenobiotic_pharmacok1.27006975
64MP0003937_abnormal_limbs/digits/tail_de1.26814429
65MP0003698_abnormal_male_reproductive1.26507115
66MP0000313_abnormal_cell_death1.26503885
67MP0003942_abnormal_urinary_system1.24676619
68MP0002733_abnormal_thermal_nociception1.24183283
69MP0002019_abnormal_tumor_incidence1.23923914
70MP0001486_abnormal_startle_reflex1.22523744
71MP0000653_abnormal_sex_gland1.22507638
72MP0002086_abnormal_extraembryonic_tissu1.22423045
73MP0005394_taste/olfaction_phenotype1.20347244
74MP0005499_abnormal_olfactory_system1.20347244
75MP0004130_abnormal_muscle_cell1.19969420
76MP0001905_abnormal_dopamine_level1.18310247
77MP0002734_abnormal_mechanical_nocicepti1.18170866
78MP0004381_abnormal_hair_follicle1.16955022
79MP0003011_delayed_dark_adaptation1.16796551
80MP0006276_abnormal_autonomic_nervous1.16678604
81MP0000358_abnormal_cell_content/1.16438639
82MP0002067_abnormal_sensory_capabilities1.15801584
83MP0005253_abnormal_eye_physiology1.11415434
84MP0001440_abnormal_grooming_behavior1.10477861
85MP0005084_abnormal_gallbladder_morpholo1.10124526
86MP0002557_abnormal_social/conspecific_i1.08273534
87MP0000778_abnormal_nervous_system1.08050895
88MP0010030_abnormal_orbit_morphology1.07615222
89MP0005386_behavior/neurological_phenoty1.06674101
90MP0004924_abnormal_behavior1.06674101
91MP0002928_abnormal_bile_duct1.06188932
92MP0010307_abnormal_tumor_latency1.04720074
93MP0005187_abnormal_penis_morphology1.04321052
94MP0003136_yellow_coat_color1.02812773
95MP0004043_abnormal_pH_regulation1.02108485
96MP0001919_abnormal_reproductive_system0.99912700
97MP0003938_abnormal_ear_development0.98684193
98MP0004197_abnormal_fetal_growth/weight/0.98551403
99MP0005195_abnormal_posterior_eye0.98180781
100MP0003315_abnormal_perineum_morphology0.97909876
101MP0005075_abnormal_melanosome_morpholog0.97391374
102MP0000647_abnormal_sebaceous_gland0.97280108
103MP0002161_abnormal_fertility/fecundity0.97089995
104MP0002752_abnormal_somatic_nervous0.96858878
105MP0001986_abnormal_taste_sensitivity0.96800695
106MP0005220_abnormal_exocrine_pancreas0.96588896
107MP0004147_increased_porphyrin_level0.96274049
108MP0002822_catalepsy0.93813805
109MP0002160_abnormal_reproductive_system0.93583997
110MP0000490_abnormal_crypts_of0.91887000
111MP0002138_abnormal_hepatobiliary_system0.91366292
112MP0008260_abnormal_autophagy0.90952417
113MP0003283_abnormal_digestive_organ0.90680853
114MP0005410_abnormal_fertilization0.90267499
115MP0006036_abnormal_mitochondrial_physio0.90210418
116MP0002163_abnormal_gland_morphology0.89816300
117MP0005076_abnormal_cell_differentiation0.89273702
118MP0001293_anophthalmia0.88669665
119MP0002277_abnormal_respiratory_mucosa0.88641951
120MP0003806_abnormal_nucleotide_metabolis0.88254697
121MP0000026_abnormal_inner_ear0.88156343
122MP0006072_abnormal_retinal_apoptosis0.86555683
123MP0003638_abnormal_response/metabolism_0.86470984
124MP0005266_abnormal_metabolism0.86317079
125MP0005384_cellular_phenotype0.85378317
126MP0009333_abnormal_splenocyte_physiolog0.84959408
127MP0009046_muscle_twitch0.84784284
128MP0000372_irregular_coat_pigmentation0.81135146
129MP0004859_abnormal_synaptic_plasticity0.80778472
130MP0003861_abnormal_nervous_system0.80639325
131MP0004142_abnormal_muscle_tone0.79555897
132MP0001324_abnormal_eye_pigmentation0.79530881
133MP0008789_abnormal_olfactory_epithelium0.79218225
134MP0004264_abnormal_extraembryonic_tissu0.78045868
135MP0002269_muscular_atrophy0.77362370
136MP0002693_abnormal_pancreas_physiology0.75853230
137MP0001984_abnormal_olfaction0.75588877
138MP0004134_abnormal_chest_morphology0.75362561
139MP0003763_abnormal_thymus_physiology0.75106504
140MP0005621_abnormal_cell_physiology0.74412840
141MP0001727_abnormal_embryo_implantation0.74364794
142MP0003635_abnormal_synaptic_transmissio0.73038292
143MP0001963_abnormal_hearing_physiology0.72422479
144MP0001119_abnormal_female_reproductive0.72284887
145MP0008872_abnormal_physiological_respon0.72127532
146MP0000955_abnormal_spinal_cord0.71501998
147MP0005379_endocrine/exocrine_gland_phen0.70625332
148MP0008770_decreased_survivor_rate0.69765259
149MP0005174_abnormal_tail_pigmentation0.69504859
150MP0004270_analgesia0.69350612
151MP0002095_abnormal_skin_pigmentation0.69255495
152MP0002063_abnormal_learning/memory/cond0.69171212
153MP0009250_abnormal_appendicular_skeleto0.68619097
154MP0000230_abnormal_systemic_arterial0.66906458
155MP0002882_abnormal_neuron_morphology0.66054443
156MP0001286_abnormal_eye_development0.65530166
157MP0000427_abnormal_hair_cycle0.65130714
158MP0001502_abnormal_circadian_rhythm0.64246255
159MP0002064_seizures0.63157021
160MP0002736_abnormal_nociception_after0.62829454
161MP0005389_reproductive_system_phenotype0.62561913
162MP0004811_abnormal_neuron_physiology0.61635857
163MP0003646_muscle_fatigue0.61335571
164MP0000703_abnormal_thymus_morphology0.60292249
165MP0002572_abnormal_emotion/affect_behav0.59936262
166MP0003699_abnormal_female_reproductive0.59883115
167MP0002751_abnormal_autonomic_nervous0.59029313
168MP0005395_other_phenotype0.58947032
169MP0008995_early_reproductive_senescence0.58611461
170MP0002127_abnormal_cardiovascular_syste0.58091775
171MP0000678_abnormal_parathyroid_gland0.57845280
172MP0003879_abnormal_hair_cell0.56335255
173MP0002332_abnormal_exercise_endurance0.55281822
174MP0009672_abnormal_birth_weight0.54883536

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)6.41173483
2Birth length less than 3rd percentile (HP:0003561)5.94298096
3Limb dystonia (HP:0002451)4.95852208
4Breast hypoplasia (HP:0003187)4.95041032
5Cerebral hypomyelination (HP:0006808)4.67685976
6Abnormality of the labia minora (HP:0012880)4.66104144
7Limb hypertonia (HP:0002509)4.21530912
8Medial flaring of the eyebrow (HP:0010747)4.15180310
9Abnormal pupillary function (HP:0007686)4.11329361
10Type II lissencephaly (HP:0007260)3.97905032
11Ependymoma (HP:0002888)3.75075566
12Patellar aplasia (HP:0006443)3.72975425
13Abnormality of midbrain morphology (HP:0002418)3.58538057
14Molar tooth sign on MRI (HP:0002419)3.58538057
15Aplasia/Hypoplasia of the patella (HP:0006498)3.46289845
16Pendular nystagmus (HP:0012043)3.44803583
17Carpal bone hypoplasia (HP:0001498)3.37977390
18Medulloblastoma (HP:0002885)3.26088460
193-Methylglutaconic aciduria (HP:0003535)3.22428319
20True hermaphroditism (HP:0010459)3.08387651
21Impulsivity (HP:0100710)3.06718678
22Abnormality of the lower motor neuron (HP:0002366)3.06472824
23Abolished electroretinogram (ERG) (HP:0000550)3.02951624
24Congenital stationary night blindness (HP:0007642)2.97663222
25Oral leukoplakia (HP:0002745)2.92569939
26Decreased central vision (HP:0007663)2.91947251
27Hyperventilation (HP:0002883)2.88307984
28Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.87636726
29Rough bone trabeculation (HP:0100670)2.85601552
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84368147
31Nephronophthisis (HP:0000090)2.84022683
32Absent radius (HP:0003974)2.82103575
33Premature ovarian failure (HP:0008209)2.81173490
34Chromsome breakage (HP:0040012)2.78648581
35Abnormal number of erythroid precursors (HP:0012131)2.77018212
36CNS hypomyelination (HP:0003429)2.72870274
37Retinal dysplasia (HP:0007973)2.70049479
38Abnormality of the renal cortex (HP:0011035)2.70033686
39Genetic anticipation (HP:0003743)2.68165748
40Concave nail (HP:0001598)2.64032169
41Aplasia involving forearm bones (HP:0009822)2.62895343
42Absent forearm bone (HP:0003953)2.62895343
43Supernumerary spleens (HP:0009799)2.61641532
44Degeneration of anterior horn cells (HP:0002398)2.61181011
45Abnormality of the anterior horn cell (HP:0006802)2.61181011
46Aplastic anemia (HP:0001915)2.60247858
47Abnormality of alanine metabolism (HP:0010916)2.58946223
48Hyperalaninemia (HP:0003348)2.58946223
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.58946223
50Severe visual impairment (HP:0001141)2.57590613
51Selective tooth agenesis (HP:0001592)2.55600783
52Progressive cerebellar ataxia (HP:0002073)2.55290890
53Chronic hepatic failure (HP:0100626)2.55272822
54Renal cortical cysts (HP:0000803)2.51930847
55Shawl scrotum (HP:0000049)2.51825879
56Rib fusion (HP:0000902)2.51692050
57Aplasia/hypoplasia of the humerus (HP:0006507)2.51608470
58Atrophy/Degeneration involving motor neurons (HP:0007373)2.51421143
59Astrocytoma (HP:0009592)2.51027378
60Abnormality of the astrocytes (HP:0100707)2.51027378
61Cerebellar dysplasia (HP:0007033)2.50238604
62Agnosia (HP:0010524)2.48990414
63Rhabdomyosarcoma (HP:0002859)2.46789811
64Lissencephaly (HP:0001339)2.41879351
65Mitochondrial inheritance (HP:0001427)2.40577599
66Abnormality of the ileum (HP:0001549)2.39825505
67Colon cancer (HP:0003003)2.38090790
68Methylmalonic acidemia (HP:0002912)2.37410627
69Congenital, generalized hypertrichosis (HP:0004540)2.36282564
70Meckel diverticulum (HP:0002245)2.35037559
71Broad-based gait (HP:0002136)2.34980435
72Absent thumb (HP:0009777)2.34666899
73Neoplasm of the oral cavity (HP:0100649)2.33675961
74Tongue fasciculations (HP:0001308)2.33356190
75Delusions (HP:0000746)2.32519876
76Inability to walk (HP:0002540)2.32238747
77Unsteady gait (HP:0002317)2.31917223
78Focal motor seizures (HP:0011153)2.31739175
79Abnormality of the renal medulla (HP:0100957)2.28563377
80Bony spicule pigmentary retinopathy (HP:0007737)2.28374723
81Abnormality of the preputium (HP:0100587)2.27173235
82Increased CSF lactate (HP:0002490)2.26911275
83Increased hepatocellular lipid droplets (HP:0006565)2.25507506
84Secondary amenorrhea (HP:0000869)2.25275973
85Aplasia/Hypoplasia of the uvula (HP:0010293)2.25037630
86Amyotrophic lateral sclerosis (HP:0007354)2.24960630
87Protruding tongue (HP:0010808)2.24739888
88Abnormality of cells of the erythroid lineage (HP:0012130)2.24552898
89Postnatal microcephaly (HP:0005484)2.24112875
90Gaze-evoked nystagmus (HP:0000640)2.22175952
91Hepatocellular necrosis (HP:0001404)2.21696264
92Agitation (HP:0000713)2.20079591
93Congenital sensorineural hearing impairment (HP:0008527)2.19663641
94Severe muscular hypotonia (HP:0006829)2.19096546
95Glioma (HP:0009733)2.17819347
96Abnormal rod and cone electroretinograms (HP:0008323)2.17669721
97Hepatic necrosis (HP:0002605)2.17586693
98Bone marrow hypocellularity (HP:0005528)2.17539427
99Rectovaginal fistula (HP:0000143)2.17470600
100Rectal fistula (HP:0100590)2.17470600
101Lipid accumulation in hepatocytes (HP:0006561)2.16256004
102Furrowed tongue (HP:0000221)2.14606185
103Increased corneal curvature (HP:0100692)2.14224751
104Keratoconus (HP:0000563)2.14224751
105Attenuation of retinal blood vessels (HP:0007843)2.11556690
106Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10742594
107Breast aplasia (HP:0100783)2.09959052
108Dysautonomia (HP:0002459)2.08999402
109Gait imbalance (HP:0002141)2.08925379
110Short humerus (HP:0005792)2.08614432
111Abnormal trabecular bone morphology (HP:0100671)2.08257414
112Microretrognathia (HP:0000308)2.07124848
113Progressive macrocephaly (HP:0004481)2.05511422
114Muscle fibrillation (HP:0010546)2.05436900
115Acute necrotizing encephalopathy (HP:0006965)2.05066578
116Premature graying of hair (HP:0002216)2.03933296
117Large for gestational age (HP:0001520)2.03378716
118Abnormal respiratory epithelium morphology (HP:0012253)2.01353160
119Abnormal respiratory motile cilium morphology (HP:0005938)2.01353160
120Neoplasm of striated muscle (HP:0009728)2.00575442
121Trismus (HP:0000211)2.00040090
122Aplasia/Hypoplasia of the breasts (HP:0010311)1.99440783
123Progressive inability to walk (HP:0002505)1.99418386
124Abnormality of chromosome stability (HP:0003220)1.99293545
125Genital tract atresia (HP:0001827)1.99089074
126Duodenal stenosis (HP:0100867)1.98818921
127Small intestinal stenosis (HP:0012848)1.98818921
128Vaginal atresia (HP:0000148)1.98630887
129Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98162485
130Aplasia/Hypoplasia of the tibia (HP:0005772)1.97132639
131Sclerocornea (HP:0000647)1.97089604
132Congenital primary aphakia (HP:0007707)1.97085990
133Cystic liver disease (HP:0006706)1.96556895
134Pachygyria (HP:0001302)1.96353402
135Missing ribs (HP:0000921)1.95740983
136Aplasia/Hypoplasia of the spleen (HP:0010451)1.94000797
137Methylmalonic aciduria (HP:0012120)1.93941374
138Asplenia (HP:0001746)1.92236796
139Sloping forehead (HP:0000340)1.90961399
140Chorioretinal atrophy (HP:0000533)1.90752818
141Poor suck (HP:0002033)1.90383028
142Morphological abnormality of the middle ear (HP:0008609)1.88492412
143Personality changes (HP:0000751)1.87578821
144Intestinal fistula (HP:0100819)1.87105071
145Tubular atrophy (HP:0000092)1.86570560
146Abnormal hair whorl (HP:0010721)1.86227972
147Optic nerve hypoplasia (HP:0000609)1.86185349
148Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85413624
149Abnormal lung lobation (HP:0002101)1.85244628
150Decreased activity of mitochondrial respiratory chain (HP:0008972)1.85168787
151Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.85168787
152Facial hemangioma (HP:0000329)1.85009053
153Neoplasm of the pancreas (HP:0002894)1.84759752
154Spinal muscular atrophy (HP:0007269)1.84696643
155Cellular immunodeficiency (HP:0005374)1.84023301
156Renal Fanconi syndrome (HP:0001994)1.83907321
157Male pseudohermaphroditism (HP:0000037)1.83615953
158Abnormal mitochondria in muscle tissue (HP:0008316)1.83264928
159Emotional lability (HP:0000712)1.82615241
160Polydipsia (HP:0001959)1.82404823
161Abnormal drinking behavior (HP:0030082)1.82404823
162Horseshoe kidney (HP:0000085)1.82152163
163Decreased circulating renin level (HP:0003351)1.81961892
164Nephrogenic diabetes insipidus (HP:0009806)1.81278450
165Abnormal number of incisors (HP:0011064)1.80864660
166Muscle fiber atrophy (HP:0100295)1.80787662
167Pancreatic cysts (HP:0001737)1.80611134
168Abnormality of the motor neurons (HP:0002450)1.79522820
169Abnormal neuron morphology (HP:0012757)1.79522820
170Myelodysplasia (HP:0002863)1.79462862
171Tracheoesophageal fistula (HP:0002575)1.79402736
172Aplasia/hypoplasia of the uterus (HP:0008684)1.79292133
173Delayed puberty (HP:0000823)1.79278906
174Hemiparesis (HP:0001269)1.79229554
175Facial cleft (HP:0002006)1.78418597
176Pancreatic fibrosis (HP:0100732)1.78326560
177Aplasia/Hypoplasia involving the musculature (HP:0001460)1.77594848
178Conjunctival hamartoma (HP:0100780)1.77219233
179Progressive muscle weakness (HP:0003323)1.77025814
180Acute encephalopathy (HP:0006846)1.76283098
181Postaxial hand polydactyly (HP:0001162)1.76175310
182Abdominal situs inversus (HP:0003363)1.75523561
183Abnormality of abdominal situs (HP:0011620)1.75523561
184Basal cell carcinoma (HP:0002671)1.75148625
185Short tibia (HP:0005736)1.74565393
186Type 2 muscle fiber atrophy (HP:0003554)1.74091544
187Small hand (HP:0200055)1.73570341
188Multicystic kidney dysplasia (HP:0000003)1.72380425
189Vaginal fistula (HP:0004320)1.72038640
190Abnormality of glycolysis (HP:0004366)1.71819987
191Increased serum pyruvate (HP:0003542)1.71819987
192Abnormal ciliary motility (HP:0012262)1.71753814
193Increased serum lactate (HP:0002151)1.70387456
194Abnormality of the salivary glands (HP:0010286)1.70189282
195Dialeptic seizures (HP:0011146)1.69744787
196Abnormality of the nasal septum (HP:0000419)1.68433605
197Congenital hepatic fibrosis (HP:0002612)1.68019760

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.83013224
2FRK4.51955308
3ADRBK24.41872222
4WEE13.55639918
5GRK13.34307128
6ZAK2.91256633
7TSSK62.77074178
8NEK12.76939842
9CDC72.59654174
10AKT32.59244072
11TESK22.59069138
12BMPR1B2.52547337
13TAOK32.51659232
14NEK22.46107390
15TTK2.43695928
16EPHA22.36382617
17EIF2AK12.30242381
18MAPK132.26318729
19ACVR1B2.18402878
20PLK12.18245015
21NUAK12.10037044
22WNK42.04238915
23PLK42.02594358
24MAP4K21.97906057
25PDK41.94045217
26PDK31.94045217
27OXSR11.77558776
28BRSK21.72369463
29PLK31.61557250
30BRAF1.60886630
31CHEK21.57647363
32BRSK11.57104356
33STK391.56215080
34MAP3K91.54855828
35CDK121.51593952
36AURKA1.48919084
37CCNB11.48326010
38PNCK1.44700371
39CDK81.44424729
40SIK21.43900918
41INSRR1.43051532
42ARAF1.42388888
43CDK71.39959491
44DAPK11.36788924
45ATR1.28536286
46PRPF4B1.26431798
47STK161.24596941
48DAPK21.17583816
49TLK11.16150057
50MAP2K71.15967070
51EIF2AK31.15774997
52SRPK11.15696368
53LATS21.15115084
54TXK1.13388183
55RPS6KB21.12354096
56BRD41.11979046
57ADRBK11.10581058
58CHEK11.09676562
59TESK11.09675807
60PDK21.07312014
61PHKG11.02715438
62PHKG21.02715438
63PRKD21.01011323
64VRK11.00920696
65RPS6KA50.98727086
66AURKB0.96295899
67CDK190.95382743
68SIK30.94607409
69PRKCI0.92879533
70MAPKAPK50.92782209
71NTRK20.92355200
72DYRK20.92063330
73PRKCE0.91097656
74NME10.90250223
75CSNK1G20.89165210
76VRK20.88909617
77TIE10.88637964
78PASK0.88168694
79MAPKAPK30.85528043
80TYRO30.85154244
81PKN10.84120542
82GRK50.83950499
83CDK20.82694509
84SCYL20.81457057
85OBSCN0.81348142
86PLK20.79291585
87PAK30.77268468
88MINK10.76859218
89IKBKB0.76568588
90MAP3K120.76390856
91PAK10.75944224
92ALK0.74638933
93MUSK0.74386661
94BCR0.73613366
95TNIK0.73079752
96PAK40.72668258
97GRK60.72476873
98CSNK1G10.71349770
99CDK40.71340093
100TRIM280.70500659
101MAP2K20.69416821
102CDK180.69272650
103STK100.69180509
104CAMK10.69110113
105CSNK1G30.68406417
106TEC0.67552555
107BCKDK0.66486799
108CAMK40.65921487
109MAP2K60.65737842
110CSNK1A1L0.64717189
111ERBB20.63115066
112ATM0.61564721
113CDK10.60954505
114CAMK2A0.60680492
115CDK150.60655313
116CDK11A0.60141466
117ICK0.59539287
118STK38L0.59361423
119GRK70.59324091
120PTK2B0.58354578
121CSNK2A20.58069017
122CDK140.57708364
123PIM20.56754370
124MAP3K70.56727460
125RPS6KA40.56167132
126WNK30.54832862
127MAP3K110.54777378
128NME20.54361688
129CAMKK20.54077250
130CSNK1A10.54000610
131CSNK1E0.53585624
132STK110.53016413
133ITK0.52158149
134MAPK150.51607055
135CSNK2A10.51414146
136PAK60.51090264
137MAP3K80.50837274
138PRKACA0.50568272
139CHUK0.49310306
140SYK0.48816185
141MELK0.48671883
142DYRK30.47848885
143TAOK10.44976357
144PRKD30.44433452
145CASK0.43658653
146PRKCG0.40809268
147PRKAA10.39075321
148RAF10.37020231
149KSR10.36447369
150PINK10.36363267
151MKNK20.35892315
152MATK0.35271972
153CSNK1D0.34813009
154MARK10.34803074
155MST40.34583091
156PRKCA0.33284485
157NTRK30.31779008
158WNK10.31241070
159MAP3K40.30395703
160CDK30.29849802
161YES10.29247360
162EPHB20.28503681
163TNK20.28154484
164PRKCZ0.27434912
165PRKACB0.26952451
166PRKAA20.26795680

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.27859716
2Mismatch repair_Homo sapiens_hsa034304.21768200
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.98920640
4RNA polymerase_Homo sapiens_hsa030203.81019219
5Proteasome_Homo sapiens_hsa030503.55655663
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.33315263
7RNA transport_Homo sapiens_hsa030133.25289837
8Base excision repair_Homo sapiens_hsa034103.06324863
9Spliceosome_Homo sapiens_hsa030402.99721244
10Nucleotide excision repair_Homo sapiens_hsa034202.78112005
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.76505805
12Homologous recombination_Homo sapiens_hsa034402.58032056
13Tryptophan metabolism_Homo sapiens_hsa003802.55028775
14Cell cycle_Homo sapiens_hsa041102.44921513
15Pyrimidine metabolism_Homo sapiens_hsa002402.43084298
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.37435596
17Histidine metabolism_Homo sapiens_hsa003402.19125139
18Ribosome_Homo sapiens_hsa030102.19059876
19Vitamin B6 metabolism_Homo sapiens_hsa007502.09597500
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.09270770
21Basal transcription factors_Homo sapiens_hsa030222.08819802
22Phenylalanine metabolism_Homo sapiens_hsa003602.01577576
23Fanconi anemia pathway_Homo sapiens_hsa034601.94248681
24Nitrogen metabolism_Homo sapiens_hsa009101.91322501
25mRNA surveillance pathway_Homo sapiens_hsa030151.84732296
26Linoleic acid metabolism_Homo sapiens_hsa005911.80263986
27One carbon pool by folate_Homo sapiens_hsa006701.73201908
28Morphine addiction_Homo sapiens_hsa050321.70943657
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66785572
30RNA degradation_Homo sapiens_hsa030181.66089807
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.64379433
32Serotonergic synapse_Homo sapiens_hsa047261.61358134
33Oocyte meiosis_Homo sapiens_hsa041141.59517022
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53517113
35Ether lipid metabolism_Homo sapiens_hsa005651.53393402
36Cocaine addiction_Homo sapiens_hsa050301.52197383
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49054924
38Purine metabolism_Homo sapiens_hsa002301.45051084
39Caffeine metabolism_Homo sapiens_hsa002321.43169246
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30367303
41Synaptic vesicle cycle_Homo sapiens_hsa047211.30216642
42Fructose and mannose metabolism_Homo sapiens_hsa000511.29710886
43p53 signaling pathway_Homo sapiens_hsa041151.27965325
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27830852
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26685573
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.24129956
47Biosynthesis of amino acids_Homo sapiens_hsa012301.20442514
48Tyrosine metabolism_Homo sapiens_hsa003501.20277254
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20107386
50Dorso-ventral axis formation_Homo sapiens_hsa043201.19147044
51Systemic lupus erythematosus_Homo sapiens_hsa053221.17798334
52Butanoate metabolism_Homo sapiens_hsa006501.17766006
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.17273121
54Chemical carcinogenesis_Homo sapiens_hsa052041.17139166
55Protein export_Homo sapiens_hsa030601.14690242
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12725268
57Non-homologous end-joining_Homo sapiens_hsa034501.10435900
58Epstein-Barr virus infection_Homo sapiens_hsa051691.09160059
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08503739
60Circadian entrainment_Homo sapiens_hsa047131.06572628
61Glutamatergic synapse_Homo sapiens_hsa047241.06186430
62Olfactory transduction_Homo sapiens_hsa047401.05254575
63Collecting duct acid secretion_Homo sapiens_hsa049661.04632488
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04094045
65Folate biosynthesis_Homo sapiens_hsa007901.03642891
66Huntingtons disease_Homo sapiens_hsa050161.02370100
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98127722
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.96247381
69Pentose phosphate pathway_Homo sapiens_hsa000300.96076322
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94982508
71Regulation of autophagy_Homo sapiens_hsa041400.93317950
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.93246248
73Oxidative phosphorylation_Homo sapiens_hsa001900.89286762
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.86994707
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85529535
76Peroxisome_Homo sapiens_hsa041460.81489002
77Insulin secretion_Homo sapiens_hsa049110.81414662
78Parkinsons disease_Homo sapiens_hsa050120.80859109
79Retinol metabolism_Homo sapiens_hsa008300.78645685
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.78624732
81Sulfur metabolism_Homo sapiens_hsa009200.77566326
82Long-term depression_Homo sapiens_hsa047300.77251803
83Galactose metabolism_Homo sapiens_hsa000520.73248069
84Carbon metabolism_Homo sapiens_hsa012000.69927920
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69182007
86Glycerolipid metabolism_Homo sapiens_hsa005610.68689648
87Ovarian steroidogenesis_Homo sapiens_hsa049130.67887178
88Nicotine addiction_Homo sapiens_hsa050330.67689444
89Melanoma_Homo sapiens_hsa052180.64202574
90Cholinergic synapse_Homo sapiens_hsa047250.62949919
91Calcium signaling pathway_Homo sapiens_hsa040200.61298742
92Vibrio cholerae infection_Homo sapiens_hsa051100.60893118
93ABC transporters_Homo sapiens_hsa020100.60308161
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59780161
95Fatty acid elongation_Homo sapiens_hsa000620.58824977
96Antigen processing and presentation_Homo sapiens_hsa046120.56992469
97Vitamin digestion and absorption_Homo sapiens_hsa049770.54948188
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54559707
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54546824
100Oxytocin signaling pathway_Homo sapiens_hsa049210.52851216
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51897907
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51585718
103Primary immunodeficiency_Homo sapiens_hsa053400.50974255
104Graft-versus-host disease_Homo sapiens_hsa053320.50622774
105mTOR signaling pathway_Homo sapiens_hsa041500.50117680
106Hippo signaling pathway_Homo sapiens_hsa043900.49880458
107Fat digestion and absorption_Homo sapiens_hsa049750.49041120
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48581689
109Salivary secretion_Homo sapiens_hsa049700.47832298
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47366463
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45924524
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45789365
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45374347
114Steroid biosynthesis_Homo sapiens_hsa001000.44700377
115Type I diabetes mellitus_Homo sapiens_hsa049400.43782339
116Renin secretion_Homo sapiens_hsa049240.43650287
117cAMP signaling pathway_Homo sapiens_hsa040240.43447534
118Viral carcinogenesis_Homo sapiens_hsa052030.42255515
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.40864321
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40004709
121Type II diabetes mellitus_Homo sapiens_hsa049300.39763617
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38962924
123Long-term potentiation_Homo sapiens_hsa047200.38304172
124Colorectal cancer_Homo sapiens_hsa052100.37634509
125Selenocompound metabolism_Homo sapiens_hsa004500.36990270
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36846957
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.36416998
128MAPK signaling pathway_Homo sapiens_hsa040100.36208940
129HTLV-I infection_Homo sapiens_hsa051660.36184207
130Arachidonic acid metabolism_Homo sapiens_hsa005900.34922140
131Pyruvate metabolism_Homo sapiens_hsa006200.33095573
132Sulfur relay system_Homo sapiens_hsa041220.32482956
133Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31481151
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30792634
135Alzheimers disease_Homo sapiens_hsa050100.30217406
136Phototransduction_Homo sapiens_hsa047440.29386227
137Hedgehog signaling pathway_Homo sapiens_hsa043400.29172247
138Amphetamine addiction_Homo sapiens_hsa050310.26933337
139Thyroid cancer_Homo sapiens_hsa052160.26432361
140Metabolic pathways_Homo sapiens_hsa011000.26262407
141GABAergic synapse_Homo sapiens_hsa047270.25781996
142Taste transduction_Homo sapiens_hsa047420.24342191
143Drug metabolism - other enzymes_Homo sapiens_hsa009830.22510977
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20932237
145Alcoholism_Homo sapiens_hsa050340.19886844
146Herpes simplex infection_Homo sapiens_hsa051680.19428814
147Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18647873
148Wnt signaling pathway_Homo sapiens_hsa043100.18397784
149Cardiac muscle contraction_Homo sapiens_hsa042600.16330733
150Dopaminergic synapse_Homo sapiens_hsa047280.16150486
151Notch signaling pathway_Homo sapiens_hsa043300.15542602
152Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15300258
153Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.14901262
154Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14067942
155Gap junction_Homo sapiens_hsa045400.13905161
156HIF-1 signaling pathway_Homo sapiens_hsa040660.12482834
157Shigellosis_Homo sapiens_hsa051310.11180880
158Basal cell carcinoma_Homo sapiens_hsa052170.10635151
159Legionellosis_Homo sapiens_hsa051340.09646733
160Inositol phosphate metabolism_Homo sapiens_hsa005620.09483605
161Tight junction_Homo sapiens_hsa045300.08862666
162Thyroid hormone signaling pathway_Homo sapiens_hsa049190.06690526
163Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.06184593
164Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.06166217
165Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.05381832
166Circadian rhythm_Homo sapiens_hsa047100.05009322
167Endocytosis_Homo sapiens_hsa041440.04725973

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