ZSWIM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of acrosome reaction (GO:0060046)6.55373554
2piRNA metabolic process (GO:0034587)6.15605187
3oocyte development (GO:0048599)5.97894697
4positive regulation of histone H3-K4 methylation (GO:0051571)5.82456063
5regulation of chromatin binding (GO:0035561)5.69545870
6mitotic metaphase plate congression (GO:0007080)5.53168170
7glycine transport (GO:0015816)5.28812435
8protein localization to kinetochore (GO:0034501)5.25498084
9protein localization to chromosome, centromeric region (GO:0071459)4.95369571
10regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.84611696
11metaphase plate congression (GO:0051310)4.80891965
12retinal cone cell development (GO:0046549)4.79683526
13negative regulation of reproductive process (GO:2000242)4.72295136
14protein kinase C signaling (GO:0070528)4.69654163
15positive regulation of humoral immune response (GO:0002922)4.65888099
16regulation of cell maturation (GO:1903429)4.62752511
17attachment of spindle microtubules to kinetochore (GO:0008608)4.56746423
18mitotic chromosome condensation (GO:0007076)4.54675751
19positive regulation of hormone biosynthetic process (GO:0046886)4.50443246
20regulation of spindle organization (GO:0090224)4.46753607
21synaptonemal complex assembly (GO:0007130)4.45562702
22mitotic sister chromatid segregation (GO:0000070)4.42114336
23regulation of histone H3-K4 methylation (GO:0051569)4.38806933
24male meiosis (GO:0007140)4.31482880
25regulation of steroid hormone secretion (GO:2000831)4.28900341
26positive regulation of gastrulation (GO:2000543)4.20825204
27synaptonemal complex organization (GO:0070193)4.17643157
28establishment of chromosome localization (GO:0051303)4.16248517
29DNA methylation involved in gamete generation (GO:0043046)4.14750673
30meiotic cell cycle (GO:0051321)4.14498907
31meiotic chromosome segregation (GO:0045132)4.06061904
32protein K6-linked ubiquitination (GO:0085020)4.04068846
33regulation of histone methylation (GO:0031060)4.03308267
34DNA replication-dependent nucleosome assembly (GO:0006335)4.03219853
35DNA replication-dependent nucleosome organization (GO:0034723)4.03219853
36regulation of mitotic spindle organization (GO:0060236)4.01394251
37positive regulation of histone methylation (GO:0031062)3.96804753
38mitotic nuclear envelope disassembly (GO:0007077)3.93432991
39protein localization to chromosome (GO:0034502)3.87400082
40DNA replication checkpoint (GO:0000076)3.83733850
41negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.83631563
42primitive streak formation (GO:0090009)3.82187379
43positive regulation of mitotic sister chromatid separation (GO:1901970)3.79269369
44positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.79269369
45positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.79269369
46synapsis (GO:0007129)3.78111037
47regulation of chromosome segregation (GO:0051983)3.77942126
48microtubule depolymerization (GO:0007019)3.76540321
49sister chromatid segregation (GO:0000819)3.70182806
50nuclear envelope disassembly (GO:0051081)3.70042630
51membrane disassembly (GO:0030397)3.70042630
52positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.69634722
53histone exchange (GO:0043486)3.69161696
54chromatin remodeling at centromere (GO:0031055)3.66948975
55regulation of meiosis I (GO:0060631)3.64868236
56binding of sperm to zona pellucida (GO:0007339)3.64607034
57DNA replication-independent nucleosome assembly (GO:0006336)3.61957141
58DNA replication-independent nucleosome organization (GO:0034724)3.61957141
59spindle checkpoint (GO:0031577)3.60176648
60CENP-A containing nucleosome assembly (GO:0034080)3.58725068
61DNA synthesis involved in DNA repair (GO:0000731)3.58437746
62positive regulation of chromosome segregation (GO:0051984)3.58382613
63meiotic nuclear division (GO:0007126)3.57700133
64negative regulation of meiosis (GO:0045835)3.57491935
65reproduction (GO:0000003)3.57334273
66microtubule severing (GO:0051013)3.56470704
67nuclear pore complex assembly (GO:0051292)3.56149480
68negative regulation of chromosome segregation (GO:0051985)3.55140399
69regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.55093255
70regulation of steroid hormone biosynthetic process (GO:0090030)3.53945440
71nuclear pore organization (GO:0006999)3.51460306
72sperm-egg recognition (GO:0035036)3.49631594
73maturation of 5.8S rRNA (GO:0000460)3.49596074
74histone H3-K36 demethylation (GO:0070544)3.49363995
75multicellular organism reproduction (GO:0032504)3.48614151
76positive regulation of hormone metabolic process (GO:0032352)3.46833803
77negative regulation of mitotic sister chromatid segregation (GO:0033048)3.46440365
78negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.46440365
79negative regulation of sister chromatid segregation (GO:0033046)3.46440365
80negative regulation of mitotic sister chromatid separation (GO:2000816)3.46440365
81female gamete generation (GO:0007292)3.46437657
82negative regulation of histone modification (GO:0031057)3.44769342
83negative regulation of execution phase of apoptosis (GO:1900118)3.41049905
84chromosome segregation (GO:0007059)3.40516977
85stress granule assembly (GO:0034063)3.39243462
86histone H2A monoubiquitination (GO:0035518)3.39088790
87meiotic cell cycle process (GO:1903046)3.38799797
88resolution of meiotic recombination intermediates (GO:0000712)3.38456719
89gene silencing by RNA (GO:0031047)3.37794223
90purine nucleobase biosynthetic process (GO:0009113)3.37781402
91fusion of sperm to egg plasma membrane (GO:0007342)3.37461625
92spindle assembly checkpoint (GO:0071173)3.36064461
93DNA methylation (GO:0006306)3.35645562
94DNA alkylation (GO:0006305)3.35645562
95kinetochore organization (GO:0051383)3.34743910
96chromosome organization involved in meiosis (GO:0070192)3.34079775
97ribosome assembly (GO:0042255)3.33377206
98mitotic spindle checkpoint (GO:0071174)3.32090625
99mitotic spindle assembly checkpoint (GO:0007094)3.31903672
100histone H3-K9 demethylation (GO:0033169)3.31576803
101kinetochore assembly (GO:0051382)3.29875558
102DNA replication initiation (GO:0006270)3.27250705
103mitotic sister chromatid cohesion (GO:0007064)3.26920308
104nucleobase biosynthetic process (GO:0046112)3.26715383
105regulation of mitotic metaphase/anaphase transition (GO:0030071)3.25887491
106regulation of DNA methylation (GO:0044030)3.23925733
107citrulline biosynthetic process (GO:0019240)3.23606338
108histone lysine demethylation (GO:0070076)3.23322292
109snRNA metabolic process (GO:0016073)3.22804550
110regulation of exit from mitosis (GO:0007096)3.22000899
111oogenesis (GO:0048477)3.21932928
112L-amino acid import (GO:0043092)3.20192153
113regulation of sister chromatid segregation (GO:0033045)3.19521451
114regulation of mitotic sister chromatid separation (GO:0010965)3.19521451
115regulation of mitotic sister chromatid segregation (GO:0033047)3.19521451
116histone demethylation (GO:0016577)3.19311688
117chromatin assembly or disassembly (GO:0006333)3.19212314
118negative regulation of cAMP-mediated signaling (GO:0043951)3.17983466
119meiosis I (GO:0007127)3.14953490
120protein complex localization (GO:0031503)3.14177007
121regulation of spindle checkpoint (GO:0090231)3.13906656
122gene silencing (GO:0016458)3.11370989
123regulation of meiosis (GO:0040020)3.11286617
124regulation of histone H3-K9 methylation (GO:0051570)3.10351938
125chromosome condensation (GO:0030261)3.08854981
126histone H2A ubiquitination (GO:0033522)3.07689867
127regulation of female gonad development (GO:2000194)3.07353909
128cell-cell recognition (GO:0009988)3.07251061
129male meiosis I (GO:0007141)3.06672113
130pyrimidine dimer repair (GO:0006290)3.04996273
131DNA damage response, signal transduction resulting in transcription (GO:0042772)3.04321558
132inner cell mass cell proliferation (GO:0001833)3.04181172
133negative regulation of histone methylation (GO:0031061)3.03975732
134labyrinthine layer development (GO:0060711)3.03865466
135chromatin assembly (GO:0031497)3.02766850
136nuclear envelope organization (GO:0006998)3.02269581
137negative regulation of chromatin modification (GO:1903309)3.02129067
138nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.01846111
139phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.01159899
140monoubiquitinated protein deubiquitination (GO:0035520)3.01034838
141ribosome biogenesis (GO:0042254)3.00719477
142regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.99524769
143protein dealkylation (GO:0008214)2.97927059
144protein demethylation (GO:0006482)2.97927059
145regulation of sister chromatid cohesion (GO:0007063)2.97650129
146viral protein processing (GO:0019082)2.97200032
147base-excision repair, AP site formation (GO:0006285)2.96603419
148fertilization (GO:0009566)2.93318730
149negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.92951624
150DNA strand elongation involved in DNA replication (GO:0006271)2.91557808
151negative regulation of proteasomal protein catabolic process (GO:1901799)2.91460767
152translesion synthesis (GO:0019985)2.89863913
153maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89768932
154positive regulation of reproductive process (GO:2000243)2.88687705
155phosphatidylinositol dephosphorylation (GO:0046856)2.85207355
156regulation of double-strand break repair via homologous recombination (GO:0010569)2.82615251
157negative regulation of homotypic cell-cell adhesion (GO:0034111)2.81119022
158positive regulation of Cdc42 GTPase activity (GO:0043089)2.79682948
159positive regulation of DNA-dependent DNA replication (GO:2000105)2.79597354
160regulation of RNA export from nucleus (GO:0046831)2.78566162
161positive regulation of uterine smooth muscle contraction (GO:0070474)2.78074518
162regulation of chromatin silencing (GO:0031935)2.77897520
163regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.77648159
164positive regulation of isotype switching (GO:0045830)2.77567532
165cerebral cortex neuron differentiation (GO:0021895)2.73681023
166negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.69148912
167histone phosphorylation (GO:0016572)2.68814467

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.52577086
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.30601390
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.27841952
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.02965283
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.76704661
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.60142087
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.45520035
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.24737228
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.01726531
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.01726531
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.01726531
12AR_21909140_ChIP-Seq_LNCAP_Human2.61187657
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51953313
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51503972
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.50377179
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.47074536
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.41238441
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40705365
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.39745960
20HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.39616230
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33641548
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.32477122
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.31753956
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27050032
25MYCN_18555785_ChIP-Seq_MESCs_Mouse2.19504775
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13175883
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.11326443
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10764164
29EZH2_22144423_ChIP-Seq_EOC_Human10.3937621
30VDR_23849224_ChIP-Seq_CD4+_Human1.99168966
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98556308
32XRN2_22483619_ChIP-Seq_HELA_Human1.98224270
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.97527414
34GABP_19822575_ChIP-Seq_HepG2_Human1.94895989
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94015103
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.93921910
37* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92062613
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.90868700
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87925499
40CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.84270660
41FOXP3_21729870_ChIP-Seq_TREG_Human1.81323785
42PKCTHETA_26484144_Chip-Seq_BREAST_Human1.80900180
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.79000796
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77666042
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77450735
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.72573075
47KDM5A_27292631_Chip-Seq_BREAST_Human1.71563226
48DCP1A_22483619_ChIP-Seq_HELA_Human1.67654987
49* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64398922
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61182950
51TTF2_22483619_ChIP-Seq_HELA_Human1.59226366
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53926890
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53747903
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.52336603
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.52104311
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50491459
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47241758
58VDR_21846776_ChIP-Seq_THP-1_Human1.45342329
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44706748
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.40520578
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39884182
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39600796
63* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39437239
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39276839
65MYC_22102868_ChIP-Seq_BL_Human1.38307547
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.37405649
67CIITA_25753668_ChIP-Seq_RAJI_Human1.36528042
68* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35579457
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33335318
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31955493
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30347207
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29685444
73SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29275028
74SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29144957
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.29003052
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28175499
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.25775975
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25699688
79KAP1_22055183_ChIP-Seq_ESCs_Mouse1.21453184
80* NOTCH1_21737748_ChIP-Seq_TLL_Human1.17212875
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16565762
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15390636
83CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.13267454
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12447352
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11230312
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.10634296
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09575542
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05092473
89MYC_18940864_ChIP-ChIP_HL60_Human1.05083582
90IRF1_19129219_ChIP-ChIP_H3396_Human1.04286177
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03866775
92GATA1_26923725_Chip-Seq_HPCs_Mouse1.02300989
93TFEB_21752829_ChIP-Seq_HELA_Human1.02101841
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00742408
95* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99907988
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99069295
97TP63_19390658_ChIP-ChIP_HaCaT_Human0.97967842
98TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.96799934
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96407768
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95362473
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94333120
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92921239
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92896225
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92594465
105VDR_24763502_ChIP-Seq_THP-1_Human0.91084620
106ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88001542
107CTCF_21964334_Chip-Seq_Bcells_Human0.87543069
108YY1_22570637_ChIP-Seq_MALME-3M_Human0.87488736
109SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86963402
110* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86876797
111* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86475923
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86259394
113ELK1_19687146_ChIP-ChIP_HELA_Human0.86258096
114BCOR_27268052_Chip-Seq_Bcells_Human0.85857607
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84390308
116TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84261517
117NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.83214341
118SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83058390
119KAP1_27257070_Chip-Seq_ESCs_Mouse0.81864326
120POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.81452454
121CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80917294
122NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.78948129
123* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77569889
124BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.77412548
125SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76713174
126NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75514959
127SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.75263493
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74632594
129ELF1_17652178_ChIP-ChIP_JURKAT_Human0.74071313
130GATA1_19941827_ChIP-Seq_MEL86_Mouse0.72128443
131SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.70870147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.38704684
2MP0003111_abnormal_nucleus_morphology4.83194288
3MP0008877_abnormal_DNA_methylation4.79996062
4MP0008789_abnormal_olfactory_epithelium4.62631598
5MP0005394_taste/olfaction_phenotype4.53668960
6MP0005499_abnormal_olfactory_system4.53668960
7MP0010094_abnormal_chromosome_stability4.38113614
8MP0002139_abnormal_hepatobiliary_system4.35704707
9MP0004957_abnormal_blastocyst_morpholog4.24892716
10MP0003077_abnormal_cell_cycle3.96579793
11MP0003718_maternal_effect3.77347514
12MP0001929_abnormal_gametogenesis3.16837875
13MP0002653_abnormal_ependyma_morphology3.06195648
14MP0008058_abnormal_DNA_repair2.99302946
15MP0005410_abnormal_fertilization2.80012937
16MP0008057_abnormal_DNA_replication2.73530875
17MP0008007_abnormal_cellular_replicative2.69920305
18MP0002210_abnormal_sex_determination2.69302223
19MP0010234_abnormal_vibrissa_follicle2.60893876
20MP0003123_paternal_imprinting2.46258204
21MP0002138_abnormal_hepatobiliary_system2.40066088
22MP0008932_abnormal_embryonic_tissue2.36076751
23MP0001730_embryonic_growth_arrest2.34601916
24MP0000653_abnormal_sex_gland2.32373319
25MP0001145_abnormal_male_reproductive2.26248861
26MP0003698_abnormal_male_reproductive2.18723007
27MP0006292_abnormal_olfactory_placode2.16342271
28MP0000350_abnormal_cell_proliferation2.06541096
29MP0003879_abnormal_hair_cell2.03621803
30MP0010307_abnormal_tumor_latency1.93402975
31MP0003786_premature_aging1.87244992
32MP0002102_abnormal_ear_morphology1.84292929
33MP0001697_abnormal_embryo_size1.81625500
34MP0002161_abnormal_fertility/fecundity1.80843839
35MP0005380_embryogenesis_phenotype1.78878379
36MP0001672_abnormal_embryogenesis/_devel1.78878379
37MP0003699_abnormal_female_reproductive1.70393872
38MP0001119_abnormal_female_reproductive1.66404300
39MP0002085_abnormal_embryonic_tissue1.59780219
40MP0008260_abnormal_autophagy1.57258017
41MP0002080_prenatal_lethality1.54014675
42MP0003646_muscle_fatigue1.48146222
43MP0002084_abnormal_developmental_patter1.46536228
44MP0000313_abnormal_cell_death1.43465361
45MP0002396_abnormal_hematopoietic_system1.42741054
46MP0003984_embryonic_growth_retardation1.42327352
47MP0003121_genomic_imprinting1.41082271
48MP0001984_abnormal_olfaction1.37339320
49MP0002019_abnormal_tumor_incidence1.36353572
50MP0002088_abnormal_embryonic_growth/wei1.36175022
51MP0005360_urolithiasis1.32572619
52MP0005395_other_phenotype1.27516624
53MP0004510_myositis1.27126697
54MP0000465_gastrointestinal_hemorrhage1.25671015
55MP0002086_abnormal_extraembryonic_tissu1.23978646
56MP0004808_abnormal_hematopoietic_stem1.21481722
57MP0005058_abnormal_lysosome_morphology1.19467577
58MP0004233_abnormal_muscle_weight1.16751609
59MP0002089_abnormal_postnatal_growth/wei1.16389114
60MP0010352_gastrointestinal_tract_polyps1.13825214
61MP0003787_abnormal_imprinting1.10179300
62MP0002822_catalepsy1.07592590
63MP0005451_abnormal_body_composition1.06823432
64MP0005501_abnormal_skin_physiology1.06811643
65MP0002796_impaired_skin_barrier1.03116312
66MP0002234_abnormal_pharynx_morphology1.01938285
67MP0004264_abnormal_extraembryonic_tissu1.00710012
68MP0006072_abnormal_retinal_apoptosis1.00448964
69MP0002233_abnormal_nose_morphology0.99639789
70MP0000490_abnormal_crypts_of0.99533580
71MP0005621_abnormal_cell_physiology0.99507561
72MP0005384_cellular_phenotype0.98123619
73MP0004084_abnormal_cardiac_muscle0.95663076
74MP0005085_abnormal_gallbladder_physiolo0.94599124
75MP0000358_abnormal_cell_content/0.93260180
76MP0004147_increased_porphyrin_level0.92772296
77MP0001293_anophthalmia0.92384469
78MP0005076_abnormal_cell_differentiation0.91536413
79MP0003890_abnormal_embryonic-extraembry0.91115139
80MP0005389_reproductive_system_phenotype0.88998279
81MP0004197_abnormal_fetal_growth/weight/0.87712571
82MP0003656_abnormal_erythrocyte_physiolo0.85689607
83MP0005083_abnormal_biliary_tract0.84116096
84MP0005647_abnormal_sex_gland0.83049227
85MP0002160_abnormal_reproductive_system0.82777067
86MP0002735_abnormal_chemical_nociception0.82640067
87MP0003315_abnormal_perineum_morphology0.82562822
88MP0003567_abnormal_fetal_cardiomyocyte0.81164571
89MP0003221_abnormal_cardiomyocyte_apopto0.78767411
90MP0000631_abnormal_neuroendocrine_gland0.78162264
91MP0003950_abnormal_plasma_membrane0.77726717
92MP0000703_abnormal_thymus_morphology0.75908505
93MP0002928_abnormal_bile_duct0.75773183
94MP0009840_abnormal_foam_cell0.71490291
95MP0001545_abnormal_hematopoietic_system0.70524192
96MP0005397_hematopoietic_system_phenotyp0.70524192
97MP0009333_abnormal_splenocyte_physiolog0.70048900
98MP0002269_muscular_atrophy0.69417568
99MP0003937_abnormal_limbs/digits/tail_de0.68874015
100MP0001919_abnormal_reproductive_system0.67338623
101MP0006035_abnormal_mitochondrial_morpho0.67084130
102MP0000678_abnormal_parathyroid_gland0.67008186
103MP0002398_abnormal_bone_marrow0.65996559
104MP0002722_abnormal_immune_system0.65731591
105MP0009278_abnormal_bone_marrow0.65574889
106MP0001324_abnormal_eye_pigmentation0.62574565
107MP0001915_intracranial_hemorrhage0.62432110
108MP0003861_abnormal_nervous_system0.62394332
109MP0000689_abnormal_spleen_morphology0.61110646
110MP0002092_abnormal_eye_morphology0.60560085
111MP0006276_abnormal_autonomic_nervous0.58641474
112MP0003119_abnormal_digestive_system0.57466804
113MP0005319_abnormal_enzyme/_coenzyme0.56397771
114MP0000015_abnormal_ear_pigmentation0.56194029
115MP0005670_abnormal_white_adipose0.55734154
116MP0001664_abnormal_digestion0.55272239
117MP0008770_decreased_survivor_rate0.53884978
118MP0001529_abnormal_vocalization0.52751190
119MP0003959_abnormal_lean_body0.51286968
120MP0001986_abnormal_taste_sensitivity0.51162517
121MP0009672_abnormal_birth_weight0.49853283
122MP0003329_amyloid_beta_deposits0.49254894
123MP0003453_abnormal_keratinocyte_physiol0.48640051
124MP0005023_abnormal_wound_healing0.48054358
125MP0004811_abnormal_neuron_physiology0.47552076
126MP0003448_altered_tumor_morphology0.47466891
127MP0003183_abnormal_peptide_metabolism0.47004790
128MP0008995_early_reproductive_senescence0.46151494
129MP0001849_ear_inflammation0.45584976
130MP0003436_decreased_susceptibility_to0.44136892
131MP0002932_abnormal_joint_morphology0.43093924
132MP0009703_decreased_birth_body0.42619637
133MP0002429_abnormal_blood_cell0.42170458
134MP0010030_abnormal_orbit_morphology0.41231538
135MP0002169_no_abnormal_phenotype0.39260781
136MP0002873_normal_phenotype0.39068892
137MP0005310_abnormal_salivary_gland0.39031341

Predicted human phenotypes

RankGene SetZ-score
1Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)5.89101061
2Birth length less than 3rd percentile (HP:0003561)5.33721780
3Osteomalacia (HP:0002749)5.23244948
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.61611712
5Abdominal situs inversus (HP:0003363)4.52240154
6Abnormality of abdominal situs (HP:0011620)4.52240154
7Loss of speech (HP:0002371)4.49219211
8Breast hypoplasia (HP:0003187)4.35973971
9Male infertility (HP:0003251)4.34929225
10Impulsivity (HP:0100710)4.25347808
11Apathy (HP:0000741)4.24612463
12Diminished motivation (HP:0000745)4.23056422
13Abnormality of the labia minora (HP:0012880)4.16146322
14Septo-optic dysplasia (HP:0100842)3.88154564
15Gonadotropin excess (HP:0000837)3.85783682
16Hypokinesia (HP:0002375)3.71804843
17Facial hemangioma (HP:0000329)3.67527599
18Colon cancer (HP:0003003)3.64989600
19Infertility (HP:0000789)3.57275333
20Carpal bone hypoplasia (HP:0001498)3.56929796
21Premature ovarian failure (HP:0008209)3.49790950
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.48415375
23Chromsome breakage (HP:0040012)3.47176420
24Patellar aplasia (HP:0006443)3.41369424
25Chronic bronchitis (HP:0004469)3.39125725
26Proximal tubulopathy (HP:0000114)3.36214854
27Lip pit (HP:0100267)3.36104793
28Anterior segment dysgenesis (HP:0007700)3.28876576
29Hypophosphatemic rickets (HP:0004912)3.20182812
30Ependymoma (HP:0002888)3.15869194
31Aplasia/Hypoplasia of the patella (HP:0006498)3.12530638
32Cortical dysplasia (HP:0002539)3.04300284
33Abnormality of the anterior horn cell (HP:0006802)3.03451803
34Degeneration of anterior horn cells (HP:0002398)3.03451803
35Supernumerary spleens (HP:0009799)3.03181798
36Rhabdomyosarcoma (HP:0002859)2.98870698
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.97964227
38Upper limb muscle weakness (HP:0003484)2.97291802
39Meckel diverticulum (HP:0002245)2.96409790
40Abnormality of chromosome stability (HP:0003220)2.90179408
41Absent septum pellucidum (HP:0001331)2.87778380
42Cerebral hypomyelination (HP:0006808)2.86875116
43Abnormality of the preputium (HP:0100587)2.85201580
44Abnormality of the ileum (HP:0001549)2.81629005
45Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.79984555
46Abnormal spermatogenesis (HP:0008669)2.76555933
47Hypoplasia of the capital femoral epiphysis (HP:0003090)2.75198327
48Abnormality of the phalanges of the hallux (HP:0010057)2.73982406
49Small intestinal stenosis (HP:0012848)2.72679848
50Duodenal stenosis (HP:0100867)2.72679848
51Spinal cord compression (HP:0002176)2.72148319
52Abnormality of macrophages (HP:0004311)2.70180756
53Overlapping toe (HP:0001845)2.69229408
54Myelodysplasia (HP:0002863)2.68862918
55Flat acetabular roof (HP:0003180)2.64224958
56Rhinitis (HP:0012384)2.63765700
57Medulloblastoma (HP:0002885)2.62998038
58Generalized aminoaciduria (HP:0002909)2.61591394
59Metaphyseal irregularity (HP:0003025)2.60273363
60Conjunctival telangiectasia (HP:0000524)2.59991752
61Oligodactyly (hands) (HP:0001180)2.59238514
62Secondary amenorrhea (HP:0000869)2.59157280
63Tongue fasciculations (HP:0001308)2.56628595
64Capillary hemangiomas (HP:0005306)2.51512273
65Malnutrition (HP:0004395)2.48450551
66Thyroid carcinoma (HP:0002890)2.48449875
67Sloping forehead (HP:0000340)2.48348250
68Absent radius (HP:0003974)2.47384549
69Hand muscle atrophy (HP:0009130)2.46566450
70Abnormality of the septum pellucidum (HP:0007375)2.46299725
71Aplasia/Hypoplasia of the fovea (HP:0008060)2.46201025
72Hypoplasia of the fovea (HP:0007750)2.46201025
73Oral leukoplakia (HP:0002745)2.43912084
74Abnormal respiratory motile cilium physiology (HP:0012261)2.43419472
75Agnosia (HP:0010524)2.43085323
76Lower limb hyperreflexia (HP:0002395)2.42424867
77Abnormality of the carotid arteries (HP:0005344)2.41142994
78Aplasia/Hypoplasia of the sternum (HP:0006714)2.40170168
79Papillary thyroid carcinoma (HP:0002895)2.39664848
80Squamous cell carcinoma (HP:0002860)2.39080300
81Abnormality of the lower motor neuron (HP:0002366)2.37831691
82Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.37703027
83Heterotopia (HP:0002282)2.34977980
84Peripheral hypomyelination (HP:0007182)2.34152693
85Nasal polyposis (HP:0100582)2.34053532
86Personality changes (HP:0000751)2.34022597
87Abnormal tarsal ossification (HP:0008369)2.33776944
88Muscle fibrillation (HP:0010546)2.32655704
89Abnormality of calcium-phosphate metabolism (HP:0100530)2.30336157
90Absent/shortened dynein arms (HP:0200106)2.29441720
91Dynein arm defect of respiratory motile cilia (HP:0012255)2.29441720
92Abnormality of the vasculature of the conjunctiva (HP:0008054)2.29356922
93Absent forearm bone (HP:0003953)2.28704780
94Aplasia involving forearm bones (HP:0009822)2.28704780
95Cafe-au-lait spot (HP:0000957)2.28639700
96Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.26532158
97Basal cell carcinoma (HP:0002671)2.25954377
98Abnormality of the duodenum (HP:0002246)2.23230922
99Increased nuchal translucency (HP:0010880)2.21969176
100Neoplasm of striated muscle (HP:0009728)2.21918491
101Aplastic anemia (HP:0001915)2.21489442
102Atrophy/Degeneration involving motor neurons (HP:0007373)2.21473489
103Neoplasm of the oral cavity (HP:0100649)2.20273108
104Absent thumb (HP:0009777)2.19464312
105Microretrognathia (HP:0000308)2.19105699
106Subcapsular cataract (HP:0000523)2.14618255
107Rough bone trabeculation (HP:0100670)2.14399851
108Oligodactyly (HP:0012165)2.10906051
109Unsteady gait (HP:0002317)2.10525606
110Aplasia of the musculature (HP:0100854)2.10071792
111Shawl scrotum (HP:0000049)2.09944816
112Abnormality of the astrocytes (HP:0100707)2.09279314
113Astrocytoma (HP:0009592)2.09279314
114Neoplasm of the pancreas (HP:0002894)2.09266407
115Elevated alkaline phosphatase (HP:0003155)2.07760835
116Type 2 muscle fiber atrophy (HP:0003554)2.04454816
117Muscle stiffness (HP:0003552)2.03384665
118Azoospermia (HP:0000027)2.03379693
119Maternal diabetes (HP:0009800)2.03375062
120Prominent nose (HP:0000448)2.03135419
121Abnormal respiratory epithelium morphology (HP:0012253)2.02515097
122Abnormal respiratory motile cilium morphology (HP:0005938)2.02515097
123Muscle fiber atrophy (HP:0100295)2.01490432
124Horseshoe kidney (HP:0000085)2.00868997
125Hydroureter (HP:0000072)1.98832440
126Spinal muscular atrophy (HP:0007269)1.97449427
127Bronchiectasis (HP:0002110)1.97304289
128Cholelithiasis (HP:0001081)1.97064400
129Bone marrow hypocellularity (HP:0005528)1.96839379
130Abnormal lung lobation (HP:0002101)1.96209735
131Pancreatic fibrosis (HP:0100732)1.94415902
132Slender long bone (HP:0003100)1.94176331
133Abnormality of carpal bone ossification (HP:0006257)1.93553312
134Selective tooth agenesis (HP:0001592)1.93475279
135Abnormal gallbladder physiology (HP:0012438)1.92529490
136Cholecystitis (HP:0001082)1.92529490
137Abnormality of alkaline phosphatase activity (HP:0004379)1.92484093
138Long palpebral fissure (HP:0000637)1.91997407
139Petechiae (HP:0000967)1.91931670
140Aplasia/hypoplasia of the humerus (HP:0006507)1.91629385
141Mutism (HP:0002300)1.91569537
142Posterior subcapsular cataract (HP:0007787)1.91036656
143Absent epiphyses (HP:0010577)1.90892859
144Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.90892859
145Abnormality of the fovea (HP:0000493)1.90581498
146Wrist flexion contracture (HP:0001239)1.90231310
147Limb hypertonia (HP:0002509)1.89720879
148Renal cell carcinoma (HP:0005584)1.89477468
149Delusions (HP:0000746)1.89266290
150Short thumb (HP:0009778)1.86904071
151Ectopic kidney (HP:0000086)1.86010448
152Bronchitis (HP:0012387)1.85813428
153Bile duct proliferation (HP:0001408)1.85744649
154Abnormal biliary tract physiology (HP:0012439)1.85744649
155Neoplasm of the colon (HP:0100273)1.85485344
156Failure to thrive in infancy (HP:0001531)1.84353829
157Progressive hearing impairment (HP:0001730)1.83487321
158CNS hypomyelination (HP:0003429)1.83050191
159Hypercortisolism (HP:0001578)1.82990622
160Neuronal loss in central nervous system (HP:0002529)1.82564802
161Breast aplasia (HP:0100783)1.82402634
162Microglossia (HP:0000171)1.81308944
163Abnormal trabecular bone morphology (HP:0100671)1.78868089
164Supranuclear gaze palsy (HP:0000605)1.78791393
165Upper limb amyotrophy (HP:0009129)1.78605106
166Distal upper limb amyotrophy (HP:0007149)1.78605106
167Periodontitis (HP:0000704)1.77884089
168Microvesicular hepatic steatosis (HP:0001414)1.77253602
169Abnormal enzyme/coenzyme activity (HP:0012379)1.77130693
170Poikiloderma (HP:0001029)1.76266125
171Nausea (HP:0002018)1.74913420
172Skin pits (HP:0100276)1.72433772
173Intrahepatic cholestasis (HP:0001406)1.70656197
174Abnormality of aromatic amino acid family metabolism (HP:0004338)1.70327565
175Uterine leiomyosarcoma (HP:0002891)1.69561717
176Leiomyosarcoma (HP:0100243)1.69561717
177Hypohidrosis (HP:0000966)1.68762987
178Abnormal gallbladder morphology (HP:0012437)1.67942977
179Diminished movement (HP:0002374)1.67033770
180Dysdiadochokinesis (HP:0002075)1.66992837
181Fatigue (HP:0012378)1.66272978

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.15452182
2WEE13.86270158
3STK243.45236491
4NEK23.28384729
5TTK3.27439106
6CDC72.98350403
7MOS2.91590083
8MAP3K92.61718380
9PLK42.61395573
10CDK122.56285712
11PRKD32.49852838
12PDK42.36282121
13PDK32.36282121
14TSSK62.33573570
15PLK12.24855946
16LATS22.22101935
17NEK61.98212993
18EEF2K1.94825611
19BRSK21.93598020
20TAOK31.93515069
21BRAF1.93317639
22BMPR21.92191981
23MAP3K61.91765958
24CHEK21.90333940
25ACVR1B1.84071472
26NEK11.77342134
27ARAF1.75378858
28PLK31.68572090
29STK101.54939192
30TAOK11.42541654
31CDK71.40082247
32AURKB1.39306542
33AURKA1.37012425
34EIF2AK11.36040637
35TRIM281.33292847
36TESK21.22658689
37VRK11.21906590
38IRAK31.20967785
39BRSK11.19675752
40CDK81.19638756
41DYRK31.16894459
42CCNB11.16233932
43SRPK11.13325864
44CHEK11.12883854
45RPS6KA41.12767502
46PDK21.08057012
47PRPF4B1.07711310
48SMG11.06181776
49KSR21.05989505
50MET1.04723832
51MAP3K81.02472992
52DYRK20.99045156
53CDK40.98032260
54VRK20.96669002
55MELK0.94638756
56STK30.93321534
57ATR0.92141380
58RAF10.92053869
59PINK10.91834518
60MAP3K50.89703369
61NEK90.84260056
62CSNK1G10.84136138
63STK38L0.83653986
64TNK20.81655305
65CSNK1G30.79410021
66MAP3K130.78912348
67CDK20.74880285
68ATM0.74008418
69LATS10.73962390
70TYK20.73911747
71PNCK0.73434609
72PASK0.73112992
73PKN20.72990477
74TAOK20.72290461
75CDK90.71732306
76MAPKAPK30.69333385
77CHUK0.68076495
78MAP4K20.65627869
79PTK20.64962328
80EIF2AK30.61906337
81CSNK1G20.61869991
82PAK10.61765747
83PRKCI0.61206556
84CDK10.57385318
85STK380.56989682
86SIK20.56625374
87ERN10.56180730
88ERBB40.55852524
89BRD40.55409894
90RPS6KB20.54161857
91FLT30.52695307
92PIM20.52463896
93BLK0.52094054
94TESK10.51599060
95BCKDK0.51355531
96CLK10.49658089
97LMTK20.48659548
98PRKCZ0.47936272
99MTOR0.47694896
100MAP4K10.47352728
101MAP3K30.46654241
102EPHA20.46078146
103AKT30.45043827
104TRIB30.44557136
105CDK190.43635839
106IRAK40.43635340
107MAP3K10.42735124
108CSNK1A1L0.41857406
109SCYL20.40017631
110EPHB10.39136905
111AKT20.38559292
112KSR10.37432909
113CDK140.35934112
114PDK10.35314222
115CSF1R0.35167090
116MAP2K30.35036135
117CDK11A0.34433482
118CSNK1E0.32692366
119CDK150.31124536
120MARK30.30532755
121PRKAA10.29753192
122PIM10.28695759
123PAK60.28435704
124CSNK2A20.28096385
125NME20.26624623
126CSNK2A10.26471314
127CAMK1D0.26446026
128CDK180.26426130
129STK160.26341903
130RIPK40.25174372
131DYRK1B0.24794950
132ICK0.24315537
133MUSK0.23965067
134ALK0.23899308
135LRRK20.23155486
136NLK0.22828187
137TYRO30.22107555
138CAMK40.21614745
139MAP3K140.21188565
140CDK60.20475751
141PDPK10.19905304
142MKNK20.18268414
143MARK20.17852769

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.90477393
2Mismatch repair_Homo sapiens_hsa034303.77882072
3DNA replication_Homo sapiens_hsa030303.74726261
4Basal transcription factors_Homo sapiens_hsa030223.64032504
5Cell cycle_Homo sapiens_hsa041103.52489061
6RNA transport_Homo sapiens_hsa030133.46517258
7Vitamin B6 metabolism_Homo sapiens_hsa007503.38686077
8RNA polymerase_Homo sapiens_hsa030203.24238256
9Base excision repair_Homo sapiens_hsa034102.99004972
10Fanconi anemia pathway_Homo sapiens_hsa034602.82456284
11Homologous recombination_Homo sapiens_hsa034402.79990884
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.77653678
13Nucleotide excision repair_Homo sapiens_hsa034202.68414610
14Spliceosome_Homo sapiens_hsa030402.47693400
15Oocyte meiosis_Homo sapiens_hsa041142.41058119
16RNA degradation_Homo sapiens_hsa030182.30555573
17p53 signaling pathway_Homo sapiens_hsa041152.14456425
18Pyrimidine metabolism_Homo sapiens_hsa002402.12121946
19Glycosaminoglycan degradation_Homo sapiens_hsa005312.04392812
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.02396088
21mRNA surveillance pathway_Homo sapiens_hsa030152.00798429
22Proteasome_Homo sapiens_hsa030501.96758798
23Pentose phosphate pathway_Homo sapiens_hsa000301.78763783
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73542190
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.71136454
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.66924872
27Folate biosynthesis_Homo sapiens_hsa007901.63361769
28One carbon pool by folate_Homo sapiens_hsa006701.57341342
29Fatty acid elongation_Homo sapiens_hsa000621.47283783
30Steroid biosynthesis_Homo sapiens_hsa001001.46548140
31Purine metabolism_Homo sapiens_hsa002301.43166797
32Non-homologous end-joining_Homo sapiens_hsa034501.30712735
33Biosynthesis of amino acids_Homo sapiens_hsa012301.30122796
34Gap junction_Homo sapiens_hsa045401.23736778
35Vibrio cholerae infection_Homo sapiens_hsa051101.16000054
36Epstein-Barr virus infection_Homo sapiens_hsa051691.09735455
37Non-small cell lung cancer_Homo sapiens_hsa052231.02051397
38B cell receptor signaling pathway_Homo sapiens_hsa046621.01072544
39Ribosome_Homo sapiens_hsa030100.98592374
40Regulation of autophagy_Homo sapiens_hsa041400.95610950
41Synaptic vesicle cycle_Homo sapiens_hsa047210.95605775
42Circadian rhythm_Homo sapiens_hsa047100.93884017
43Phagosome_Homo sapiens_hsa041450.91621977
44Endometrial cancer_Homo sapiens_hsa052130.89984567
45Sulfur relay system_Homo sapiens_hsa041220.89296790
46Acute myeloid leukemia_Homo sapiens_hsa052210.88445682
47Adherens junction_Homo sapiens_hsa045200.87691145
48mTOR signaling pathway_Homo sapiens_hsa041500.86996073
49Caffeine metabolism_Homo sapiens_hsa002320.85687793
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84948865
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80802135
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80608890
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78906534
54Ovarian steroidogenesis_Homo sapiens_hsa049130.77258609
55Viral carcinogenesis_Homo sapiens_hsa052030.74757293
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.69203918
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68958974
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68585873
59Herpes simplex infection_Homo sapiens_hsa051680.68189545
60Colorectal cancer_Homo sapiens_hsa052100.67370325
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67217454
62ErbB signaling pathway_Homo sapiens_hsa040120.64968689
63Prostate cancer_Homo sapiens_hsa052150.62532962
64Legionellosis_Homo sapiens_hsa051340.61803944
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.61706439
66Osteoclast differentiation_Homo sapiens_hsa043800.61427468
67Lysosome_Homo sapiens_hsa041420.61006112
68HTLV-I infection_Homo sapiens_hsa051660.60191039
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59310692
70Thyroid cancer_Homo sapiens_hsa052160.58885543
71Pyruvate metabolism_Homo sapiens_hsa006200.58524968
72MicroRNAs in cancer_Homo sapiens_hsa052060.56571736
73Selenocompound metabolism_Homo sapiens_hsa004500.56268790
74Carbon metabolism_Homo sapiens_hsa012000.56204263
75Fructose and mannose metabolism_Homo sapiens_hsa000510.55684698
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54234607
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52776330
78Pancreatic cancer_Homo sapiens_hsa052120.52083663
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51794757
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51709691
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51097343
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.50856594
83N-Glycan biosynthesis_Homo sapiens_hsa005100.48721947
84Olfactory transduction_Homo sapiens_hsa047400.48691558
85Linoleic acid metabolism_Homo sapiens_hsa005910.46813452
86Glucagon signaling pathway_Homo sapiens_hsa049220.45524651
87Measles_Homo sapiens_hsa051620.45445234
88Endocytosis_Homo sapiens_hsa041440.44299163
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44155697
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43266103
91Antigen processing and presentation_Homo sapiens_hsa046120.42433362
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.41533312
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40761452
94FoxO signaling pathway_Homo sapiens_hsa040680.39452959
95Hepatitis C_Homo sapiens_hsa051600.38314926
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38079136
97Renin-angiotensin system_Homo sapiens_hsa046140.36608089
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36346639
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36228947
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.36002714
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35864486
102TGF-beta signaling pathway_Homo sapiens_hsa043500.32992322
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32936826
104Systemic lupus erythematosus_Homo sapiens_hsa053220.30312952
105HIF-1 signaling pathway_Homo sapiens_hsa040660.29667905
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.29621755
107Notch signaling pathway_Homo sapiens_hsa043300.29188380
108Hepatitis B_Homo sapiens_hsa051610.28383459
109Dorso-ventral axis formation_Homo sapiens_hsa043200.27474692
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25896469
111Vitamin digestion and absorption_Homo sapiens_hsa049770.24555162
112Hippo signaling pathway_Homo sapiens_hsa043900.23184547
113VEGF signaling pathway_Homo sapiens_hsa043700.22450835
114Small cell lung cancer_Homo sapiens_hsa052220.22218151
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21026362
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20793235
117Influenza A_Homo sapiens_hsa051640.19839735
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18506452
119Shigellosis_Homo sapiens_hsa051310.18087116
120AMPK signaling pathway_Homo sapiens_hsa041520.18028648
121Bladder cancer_Homo sapiens_hsa052190.17887743
122Alcoholism_Homo sapiens_hsa050340.16910042
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.16102751
124Metabolic pathways_Homo sapiens_hsa011000.14766326
125Prolactin signaling pathway_Homo sapiens_hsa049170.13761143
126Apoptosis_Homo sapiens_hsa042100.13284194
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12631003
128Estrogen signaling pathway_Homo sapiens_hsa049150.12247280
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11579935
130Chronic myeloid leukemia_Homo sapiens_hsa052200.11395524
131Inositol phosphate metabolism_Homo sapiens_hsa005620.10304757
132Insulin signaling pathway_Homo sapiens_hsa049100.09617231
133Renal cell carcinoma_Homo sapiens_hsa052110.09485031
134Choline metabolism in cancer_Homo sapiens_hsa052310.09246167
135Huntingtons disease_Homo sapiens_hsa050160.08733495
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.08271332
137Pathways in cancer_Homo sapiens_hsa052000.07527970

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