ZSWIM5P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of growth hormone secretion (GO:0060124)8.67320289
2growth hormone secretion (GO:0030252)8.21698931
3positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)7.66574615
4determination of adult lifespan (GO:0008340)6.31593056
5regulation of growth hormone secretion (GO:0060123)6.27474551
6regulation of dopamine secretion (GO:0014059)6.22159956
7phosphatidylinositol acyl-chain remodeling (GO:0036149)5.90454125
8phosphatidylserine acyl-chain remodeling (GO:0036150)5.71145565
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.54685912
10mitochondrial respiratory chain complex I assembly (GO:0032981)5.54685912
11NADH dehydrogenase complex assembly (GO:0010257)5.54685912
12protein complex biogenesis (GO:0070271)5.44008749
13neuron remodeling (GO:0016322)5.28825195
14phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.22927904
15maturation of SSU-rRNA (GO:0030490)5.18700217
16mitochondrial respiratory chain complex assembly (GO:0033108)4.91482875
17retinal cone cell development (GO:0046549)4.86964530
18ribosomal small subunit biogenesis (GO:0042274)4.85151648
19behavioral response to nicotine (GO:0035095)4.79468748
20synaptic transmission, dopaminergic (GO:0001963)4.76970994
21phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.76452776
22regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)4.55312877
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.52752690
24alkaloid metabolic process (GO:0009820)4.41046775
25phosphatidylcholine acyl-chain remodeling (GO:0036151)4.22278582
26viral transcription (GO:0019083)4.21577968
27cullin deneddylation (GO:0010388)4.10215829
28microtubule depolymerization (GO:0007019)4.09803969
29translational termination (GO:0006415)4.03071625
30cytokine biosynthetic process (GO:0042089)3.92657477
31positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.90183691
32protein import into peroxisome matrix (GO:0016558)3.78877461
33dopamine biosynthetic process (GO:0042416)3.77420423
34phosphatidic acid biosynthetic process (GO:0006654)3.76439719
35phosphatidic acid metabolic process (GO:0046473)3.76439719
36regulation of mitochondrial translation (GO:0070129)3.74781076
37negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.66006227
38mitochondrial calcium ion transport (GO:0006851)3.65449936
39water-soluble vitamin biosynthetic process (GO:0042364)3.61951795
40tRNA methylation (GO:0030488)3.58726776
41phosphatidylserine metabolic process (GO:0006658)3.56827578
42NAD biosynthetic process (GO:0009435)3.55995540
43energy coupled proton transport, down electrochemical gradient (GO:0015985)3.55655007
44ATP synthesis coupled proton transport (GO:0015986)3.55655007
45dopamine transport (GO:0015872)3.54190941
46L-fucose catabolic process (GO:0042355)3.53653333
47fucose catabolic process (GO:0019317)3.53653333
48L-fucose metabolic process (GO:0042354)3.53653333
49positive regulation of microtubule polymerization (GO:0031116)3.53470922
50chromatin remodeling at centromere (GO:0031055)3.52751091
51DNA strand renaturation (GO:0000733)3.51068133
52regulation of catecholamine secretion (GO:0050433)3.41413694
53cAMP-mediated signaling (GO:0019933)3.39159013
54regulation of mitotic spindle checkpoint (GO:1903504)3.37955992
55regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.37955992
562-oxoglutarate metabolic process (GO:0006103)3.36516343
57CENP-A containing nucleosome assembly (GO:0034080)3.35959362
58protein deneddylation (GO:0000338)3.35700560
59toxin metabolic process (GO:0009404)3.35132086
60translational elongation (GO:0006414)3.33034442
61chaperone-mediated protein complex assembly (GO:0051131)3.33004456
62respiratory chain complex IV assembly (GO:0008535)3.32471516
63cell morphogenesis involved in neuron differentiation (GO:0048667)3.29935692
64ribosomal small subunit assembly (GO:0000028)3.26471390
65SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.26105468
66cytokine metabolic process (GO:0042107)3.23594785
67cellular protein complex disassembly (GO:0043624)3.22137298
68cotranslational protein targeting to membrane (GO:0006613)3.19915373
69mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.18479166
70DNA replication-dependent nucleosome assembly (GO:0006335)3.17065630
71DNA replication-dependent nucleosome organization (GO:0034723)3.17065630
72histone H3-K9 methylation (GO:0051567)3.16999050
73protein targeting to ER (GO:0045047)3.11288831
74tyrosine metabolic process (GO:0006570)3.10757743
75bile acid and bile salt transport (GO:0015721)3.10382052
76adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.06892265
77negative regulation of synaptic transmission, GABAergic (GO:0032229)3.05707401
78cytochrome complex assembly (GO:0017004)3.05417189
79platelet dense granule organization (GO:0060155)3.03870394
80activation of adenylate cyclase activity (GO:0007190)3.02870454
81protein localization to endoplasmic reticulum (GO:0070972)2.99255311
82establishment of protein localization to endoplasmic reticulum (GO:0072599)2.96595355
83phosphatidylglycerol metabolic process (GO:0046471)2.93340070
84neurotransmitter catabolic process (GO:0042135)2.93216808
85somite rostral/caudal axis specification (GO:0032525)2.91505545
86regulation of actin nucleation (GO:0051125)2.91393717
87regulation of microtubule polymerization (GO:0031113)2.89921707
88microtubule polymerization or depolymerization (GO:0031109)2.88555664
89negative regulation of interleukin-8 production (GO:0032717)2.86669404
90mating behavior (GO:0007617)2.86413994
91electron transport chain (GO:0022900)2.85719488
92GMP metabolic process (GO:0046037)2.84518805
93phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.84462338
94respiratory electron transport chain (GO:0022904)2.84197794
95viral life cycle (GO:0019058)2.82848390
96protein localization to kinetochore (GO:0034501)2.80534543
97alditol phosphate metabolic process (GO:0052646)2.80465879
98negative regulation of DNA-templated transcription, elongation (GO:0032785)2.78949271
99pseudouridine synthesis (GO:0001522)2.72720994
100neurotransmitter metabolic process (GO:0042133)2.71868916

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.39199655
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse6.17109373
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse5.02980400
4ZNF274_21170338_ChIP-Seq_K562_Hela3.79841133
5VDR_22108803_ChIP-Seq_LS180_Human3.46523423
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.87403063
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.55733993
8MYC_18940864_ChIP-ChIP_HL60_Human2.54650902
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45377229
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33140305
11GBX2_23144817_ChIP-Seq_PC3_Human2.25575142
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21211280
13TP53_22573176_ChIP-Seq_HFKS_Human2.17726734
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05669658
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00770471
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94400211
17ESR1_15608294_ChIP-ChIP_MCF-7_Human1.92297488
18MYC_19829295_ChIP-Seq_ESCs_Human1.87993164
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.76800030
20EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.72341938
21GATA1_22025678_ChIP-Seq_K562_Human1.68371206
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.67676881
23DROSHA_22980978_ChIP-Seq_HELA_Human1.53444400
24RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.50699394
25CTCF_27219007_Chip-Seq_Bcells_Human1.47622408
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.43625274
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41837774
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41071613
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37393036
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.35732864
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.35242433
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.34344772
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33382238
34BCAT_22108803_ChIP-Seq_LS180_Human1.32946847
35GATA3_21878914_ChIP-Seq_MCF-7_Human1.32498565
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.30686989
37EZH2_22144423_ChIP-Seq_EOC_Human1.22852299
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21306466
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21281307
40SOX2_22085726_ChIP-Seq_NPCs_Mouse1.18667233
41PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17640837
42OCT4_20526341_ChIP-Seq_ESCs_Human1.17527307
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.16298783
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.15186926
45EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.13643786
46ERA_21632823_ChIP-Seq_H3396_Human1.13485131
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12379406
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11842679
49P300_27268052_Chip-Seq_Bcells_Human1.10708625
50ELK1_19687146_ChIP-ChIP_HELA_Human1.09572146
51OCT4_19829295_ChIP-Seq_ESCs_Human1.06843464
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.06122215
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.06111480
54SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.05887727
55P53_21459846_ChIP-Seq_SAOS-2_Human1.04795710
56PHF8_20622854_ChIP-Seq_HELA_Human1.04031889
57TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04001790
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.03731342
59CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03358087
60EGR1_19032775_ChIP-ChIP_M12_Human1.02200562
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02034563
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.02034563
63TTF2_22483619_ChIP-Seq_HELA_Human1.01542131
64SOX2_19829295_ChIP-Seq_ESCs_Human1.00519227
65NANOG_19829295_ChIP-Seq_ESCs_Human1.00519227
66HOXB7_26014856_ChIP-Seq_BT474_Human0.99157618
67AR_20517297_ChIP-Seq_VCAP_Human0.98022424
68ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96410187
69TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95342773
70JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94643069
71TAF2_19829295_ChIP-Seq_ESCs_Human0.94143706
72JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91384463
73CTCF_26484167_Chip-Seq_Bcells_Mouse0.90356767
74GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90064575
75AR_21572438_ChIP-Seq_LNCaP_Human0.89939177
76TP53_16413492_ChIP-PET_HCT116_Human0.89848306
77CTCF_18555785_ChIP-Seq_MESCs_Mouse0.89674084
78TP63_22573176_ChIP-Seq_HFKS_Human0.89384523
79SOX11_22085726_ChIP-Seq_ESNs_Mouse0.89355555
80NANOG_20526341_ChIP-Seq_ESCs_Human0.89253895
81BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88996679
82SMAD4_21741376_ChIP-Seq_ESCs_Human0.88551553
83NFE2_27457419_Chip-Seq_LIVER_Mouse0.88419955
84FUS_26573619_Chip-Seq_HEK293_Human0.88016856
85PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86650943
86STAT1_20625510_ChIP-Seq_HELA_Human0.86471984
87NCOR_22424771_ChIP-Seq_293T_Human0.85927131
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84967012
89BCOR_27268052_Chip-Seq_Bcells_Human0.84698659
90FOXH1_21741376_ChIP-Seq_ESCs_Human0.84495295
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.84482635
92IKZF1_21737484_ChIP-ChIP_HCT116_Human0.84240331
93EZH2_27294783_Chip-Seq_ESCs_Mouse0.84040409
94EWS_26573619_Chip-Seq_HEK293_Human0.83627751
95FLI1_27457419_Chip-Seq_LIVER_Mouse0.83210863
96CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83152963
97PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82787285
98SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.82474175
99KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82111817
100MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.81613136

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001501_abnormal_sleep_pattern4.46503587
2MP0002653_abnormal_ependyma_morphology4.26449398
3MP0006292_abnormal_olfactory_placode4.19626154
4MP0003950_abnormal_plasma_membrane4.12049786
5MP0005551_abnormal_eye_electrophysiolog3.80784425
6MP0002102_abnormal_ear_morphology3.67314359
7MP0009379_abnormal_foot_pigmentation3.40544810
8MP0005360_urolithiasis3.39810753
9MP0003303_peritoneal_inflammation2.86146321
10MP0000383_abnormal_hair_follicle2.60652670
11MP0005377_hearing/vestibular/ear_phenot2.41345306
12MP0003878_abnormal_ear_physiology2.41345306
13MP0004147_increased_porphyrin_level2.19127384
14MP0001529_abnormal_vocalization2.14627292
15MP0005451_abnormal_body_composition2.13435192
16MP0001881_abnormal_mammary_gland2.11328644
17MP0005075_abnormal_melanosome_morpholog2.09821080
18MP0003195_calcinosis1.90797839
19MP0005266_abnormal_metabolism1.89384926
20MP0000631_abnormal_neuroendocrine_gland1.84769978
21MP0008789_abnormal_olfactory_epithelium1.82526646
22MP0003806_abnormal_nucleotide_metabolis1.82493978
23MP0001485_abnormal_pinna_reflex1.78850189
24MP0003283_abnormal_digestive_organ1.75550425
25MP0003959_abnormal_lean_body1.72572327
26MP0000372_irregular_coat_pigmentation1.70325511
27MP0000569_abnormal_digit_pigmentation1.65501873
28MP0008875_abnormal_xenobiotic_pharmacok1.65022249
29MP0003315_abnormal_perineum_morphology1.64634719
30MP0003136_yellow_coat_color1.58101513
31MP0000026_abnormal_inner_ear1.49843087
32MP0010030_abnormal_orbit_morphology1.49115253
33MP0004043_abnormal_pH_regulation1.46818980
34MP0000579_abnormal_nail_morphology1.45114381
35MP0004133_heterotaxia1.40347920
36MP0002736_abnormal_nociception_after1.38896470
37MP0002876_abnormal_thyroid_physiology1.38338069
38MP0004142_abnormal_muscle_tone1.36562503
39MP0004381_abnormal_hair_follicle1.31889963
40MP0006035_abnormal_mitochondrial_morpho1.31745983
41MP0002139_abnormal_hepatobiliary_system1.27283079
42MP0005195_abnormal_posterior_eye1.26207066
43MP0008877_abnormal_DNA_methylation1.25973581
44MP0003567_abnormal_fetal_cardiomyocyte1.25704428
45MP0001905_abnormal_dopamine_level1.21840766
46MP0004185_abnormal_adipocyte_glucose1.21099784
47MP0005499_abnormal_olfactory_system1.20928345
48MP0005394_taste/olfaction_phenotype1.20928345
49MP0002234_abnormal_pharynx_morphology1.12739836
50MP0003718_maternal_effect1.09846044
51MP0003638_abnormal_response/metabolism_1.09644366
52MP0000647_abnormal_sebaceous_gland1.09350175
53MP0003632_abnormal_nervous_system1.09312830
54MP0000427_abnormal_hair_cycle1.08692656
55MP0004885_abnormal_endolymph1.04029266
56MP0003698_abnormal_male_reproductive1.00166873
57MP0002837_dystrophic_cardiac_calcinosis0.96194990
58MP0002572_abnormal_emotion/affect_behav0.94467492
59MP0001963_abnormal_hearing_physiology0.91382240
60MP0002752_abnormal_somatic_nervous0.87401651
61MP0010678_abnormal_skin_adnexa0.86109423
62MP0003119_abnormal_digestive_system0.84607458
63MP0000639_abnormal_adrenal_gland0.83556507
64MP0005386_behavior/neurological_phenoty0.82501691
65MP0004924_abnormal_behavior0.82501691
66MP0002111_abnormal_tail_morphology0.82212172
67MP0005376_homeostasis/metabolism_phenot0.81411946
68MP0004019_abnormal_vitamin_homeostasis0.80965328
69MP0004742_abnormal_vestibular_system0.77804388
70MP0005381_digestive/alimentary_phenotyp0.75852702
71MP0002557_abnormal_social/conspecific_i0.73118240
72MP0001346_abnormal_lacrimal_gland0.72897322
73MP0001663_abnormal_digestive_system0.72251653
74MP0000049_abnormal_middle_ear0.72016475
75MP0001929_abnormal_gametogenesis0.71871967
76MP0002148_abnormal_hypersensitivity_rea0.70939091
77MP0002938_white_spotting0.70199679
78MP0008872_abnormal_physiological_respon0.68188839
79MP0006036_abnormal_mitochondrial_physio0.68179816
80MP0002229_neurodegeneration0.67852411
81MP0005084_abnormal_gallbladder_morpholo0.67429410
82MP0002210_abnormal_sex_determination0.67224785
83MP0003937_abnormal_limbs/digits/tail_de0.65564661
84MP0001293_anophthalmia0.64168473
85MP0002095_abnormal_skin_pigmentation0.63794288
86MP0001790_abnormal_immune_system0.62707916
87MP0005387_immune_system_phenotype0.62707916
88MP0002272_abnormal_nervous_system0.62452536
89MP0000358_abnormal_cell_content/0.62449275
90MP0005395_other_phenotype0.62226625
91MP0003077_abnormal_cell_cycle0.61873949
92MP0001324_abnormal_eye_pigmentation0.61766522
93MP0006276_abnormal_autonomic_nervous0.56252146
94MP0005253_abnormal_eye_physiology0.56140133
95MP0003787_abnormal_imprinting0.56139495
96MP0010771_integument_phenotype0.56008254
97MP0002405_respiratory_system_inflammati0.55721931
98MP0001968_abnormal_touch/_nociception0.55578609
99MP0010386_abnormal_urinary_bladder0.55162489
100MP0001145_abnormal_male_reproductive0.52930478

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.83444317
2Birth length less than 3rd percentile (HP:0003561)5.91520006
3Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.14549384
43-Methylglutaconic aciduria (HP:0003535)5.05466272
5Abnormal number of erythroid precursors (HP:0012131)4.91822681
6Concave nail (HP:0001598)4.75310912
7Abnormality of cells of the erythroid lineage (HP:0012130)4.74489532
8Microvesicular hepatic steatosis (HP:0001414)4.67884672
9Limb dystonia (HP:0002451)3.85169661
10Aplasia/Hypoplasia of the sacrum (HP:0008517)3.61193813
11Oligodactyly (hands) (HP:0001180)3.50761617
12Acute encephalopathy (HP:0006846)3.48670680
13Breast hypoplasia (HP:0003187)3.46327974
14Renal cortical cysts (HP:0000803)3.44824405
15Abnormality of midbrain morphology (HP:0002418)3.33433698
16Molar tooth sign on MRI (HP:0002419)3.33433698
17Protruding tongue (HP:0010808)3.21919536
18Acute necrotizing encephalopathy (HP:0006965)3.15366426
19Abnormality of cochlea (HP:0000375)3.08762247
20Mitochondrial inheritance (HP:0001427)3.04245403
21Decreased electroretinogram (ERG) amplitude (HP:0000654)3.00773364
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96737969
23Adrenal hypoplasia (HP:0000835)2.96592760
24Abnormality of the renal cortex (HP:0011035)2.96452396
25Hepatocellular necrosis (HP:0001404)2.94498351
26Cheilitis (HP:0100825)2.94008073
27Abnormal mitochondria in muscle tissue (HP:0008316)2.86909230
28Long nose (HP:0003189)2.85376278
29Morphological abnormality of the inner ear (HP:0011390)2.84230187
30Prolonged QT interval (HP:0001657)2.81325937
31Breech presentation (HP:0001623)2.80161840
32Lipid accumulation in hepatocytes (HP:0006561)2.79565619
33Spastic tetraparesis (HP:0001285)2.79246710
34Attenuation of retinal blood vessels (HP:0007843)2.77738933
35Increased CSF lactate (HP:0002490)2.70667363
36Hepatic necrosis (HP:0002605)2.70372081
37Progressive inability to walk (HP:0002505)2.66328903
38Gait imbalance (HP:0002141)2.66179120
39Pancreatic cysts (HP:0001737)2.62173037
40Hypokinesia (HP:0002375)2.56922057
41Fibular hypoplasia (HP:0003038)2.55378668
42Optic disc pallor (HP:0000543)2.50691034
43Global brain atrophy (HP:0002283)2.49476104
44Tubular atrophy (HP:0000092)2.47840021
45Congenital, generalized hypertrichosis (HP:0004540)2.47317136
46Growth hormone deficiency (HP:0000824)2.46018633
47Congenital primary aphakia (HP:0007707)2.44544900
48Acute lymphatic leukemia (HP:0006721)2.42232178
49Progressive macrocephaly (HP:0004481)2.41698701
50Medial flaring of the eyebrow (HP:0010747)2.41156372
51Testicular atrophy (HP:0000029)2.34881601
52Oligodactyly (HP:0012165)2.30264515
53Increased hepatocellular lipid droplets (HP:0006565)2.27794570
54Slender long bone (HP:0003100)2.26483602
55Nephrogenic diabetes insipidus (HP:0009806)2.26133630
56Nephronophthisis (HP:0000090)2.23713676
57Maternal diabetes (HP:0009800)2.22328494
58Thrombocytosis (HP:0001894)2.22038358
59Abnormal biliary tract physiology (HP:0012439)2.21836903
60Bile duct proliferation (HP:0001408)2.21836903
61Brushfield spots (HP:0001088)2.21035903
62Clitoromegaly (HP:0000057)2.17301563
63Intellectual disability, progressive (HP:0006887)2.14387921
64Progressive microcephaly (HP:0000253)2.12936957
65Delayed CNS myelination (HP:0002188)2.10667846
66Respiratory difficulties (HP:0002880)2.10016903
67Small hand (HP:0200055)2.07928954
68Recurrent corneal erosions (HP:0000495)2.05776189
69Patellar aplasia (HP:0006443)2.05776184
70Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.03653956
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03611074
72Dicarboxylic aciduria (HP:0003215)2.03611074
73Rib fusion (HP:0000902)2.02986792
74Chronic hepatic failure (HP:0100626)2.02513997
75Agammaglobulinemia (HP:0004432)2.01673617
76Furrowed tongue (HP:0000221)2.00551987
77True hermaphroditism (HP:0010459)1.97527600
78Abnormal pupillary function (HP:0007686)1.97186710
79Bell-shaped thorax (HP:0001591)1.96061046
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.94518261
81Inability to walk (HP:0002540)1.92876322
82Increased serum lactate (HP:0002151)1.88283943
83Leukodystrophy (HP:0002415)1.87848417
84Anophthalmia (HP:0000528)1.86999668
85Cerebral edema (HP:0002181)1.86453776
86Retinal dysplasia (HP:0007973)1.86020263
87Partial agenesis of the corpus callosum (HP:0001338)1.84291359
88Aplasia/Hypoplasia of the patella (HP:0006498)1.83030834
89Lactic acidosis (HP:0003128)1.82381216
90CNS demyelination (HP:0007305)1.82211698
91Increased muscle lipid content (HP:0009058)1.80410540
92Aplasia/Hypoplasia of the fibula (HP:0006492)1.79878740
93Renal Fanconi syndrome (HP:0001994)1.74918180
94Decreased testicular size (HP:0008734)1.74418182
95Nausea (HP:0002018)1.73470249
96Constricted visual fields (HP:0001133)1.73277680
97Pancreatic fibrosis (HP:0100732)1.73170891
98Vaginal atresia (HP:0000148)1.72806917
99Back pain (HP:0003418)1.72307186
100Abnormality of the 4th metacarpal (HP:0010012)1.72051718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.55152329
2VRK24.71664721
3MAP4K23.53547672
4NME13.35183812
5MAPKAPK53.25811667
6GRK12.47366363
7EPHA42.35709188
8CHEK22.25118094
9NEK92.23494257
10CDC72.09970433
11MAPK131.99673322
12WNK31.97879652
13PIK3CG1.97146748
14ERN11.87357973
15DDR21.79748983
16VRK11.77005993
17PKN11.72832433
18MAPKAPK31.72305121
19BMPR1B1.62596663
20BRSK21.61862131
21PLK41.59439875
22ZAK1.52798564
23NEK21.48260181
24MAPK41.31851700
25NUAK11.29025295
26ACVR1B1.28525930
27UHMK11.26742666
28EEF2K1.21001614
29ADRBK21.13005542
30LATS11.10733466
31NTRK21.08668266
32MAP2K21.08607686
33KDR1.07824203
34BCKDK1.07816244
35TRPM71.04429210
36ADRBK10.98381123
37PRKCI0.85206879
38MARK30.84554135
39RPS6KB20.83367250
40PLK10.80854558
41CAMK2B0.80840629
42MATK0.78704670
43NME20.77410905
44CDK120.76922764
45RPS6KA50.76528085
46PRKCG0.73491957
47TIE10.67514779
48DYRK20.67216900
49MKNK10.66227303
50MAP2K10.64970884
51DAPK10.64392145
52SRPK10.63898099
53PASK0.62266280
54BRSK10.60442695
55MELK0.60305189
56TAF10.60281329
57MAP3K40.58418694
58PRKCZ0.58329139
59TGFBR10.54901754
60MAP3K100.54456238
61GRK60.54100884
62ATR0.53613917
63AURKA0.53146485
64CDK40.52249154
65DAPK30.48556044
66PLK30.46725720
67CDK150.44953746
68CAMK2A0.44219201
69CDK11A0.43488970
70CSNK1G30.42613436
71PRKCQ0.42155209
72ABL20.41968648
73OXSR10.40996500
74CDK180.38851014
75CSNK1G20.37540000
76STK110.37313677
77PRKACB0.35194032
78EPHB20.34712268
79AURKB0.34537204
80NEK10.34157874
81DAPK20.33412226
82TTK0.32451465
83CAMK40.32216820
84WEE10.31492759
85MKNK20.31355657
86KIT0.31264434
87PRKCB0.30611891
88PAK30.29449941
89FLT30.29253824
90CHEK10.29142814
91CSNK1G10.29096536
92CDC42BPA0.28314610
93CSNK2A10.28294202
94CDK140.27682584
95SYK0.27439603
96CDK190.27260963
97CDK60.26956229
98WNK40.26651681
99OBSCN0.26576619
100CAMK2G0.26488272

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005926.07825836
2Linoleic acid metabolism_Homo sapiens_hsa005915.55693673
3Ether lipid metabolism_Homo sapiens_hsa005653.96296440
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.36462343
5Ribosome_Homo sapiens_hsa030103.13342705
6Nicotine addiction_Homo sapiens_hsa050332.89624703
7Parkinsons disease_Homo sapiens_hsa050122.59127366
8Oxidative phosphorylation_Homo sapiens_hsa001902.53784516
9Nitrogen metabolism_Homo sapiens_hsa009102.47502305
10Arachidonic acid metabolism_Homo sapiens_hsa005902.44310621
11Homologous recombination_Homo sapiens_hsa034402.42376746
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.30707340
13Fat digestion and absorption_Homo sapiens_hsa049752.11803242
14Glycerophospholipid metabolism_Homo sapiens_hsa005641.82266326
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81790813
16DNA replication_Homo sapiens_hsa030301.81405019
17Phototransduction_Homo sapiens_hsa047441.77686059
18Arginine biosynthesis_Homo sapiens_hsa002201.75215473
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.71338302
20Huntingtons disease_Homo sapiens_hsa050161.64382284
21Alzheimers disease_Homo sapiens_hsa050101.52671708
22Butanoate metabolism_Homo sapiens_hsa006501.45417051
23Ovarian steroidogenesis_Homo sapiens_hsa049131.41906119
24Basal transcription factors_Homo sapiens_hsa030221.37234095
25Cardiac muscle contraction_Homo sapiens_hsa042601.33404558
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32938012
27RNA polymerase_Homo sapiens_hsa030201.26923651
28Mismatch repair_Homo sapiens_hsa034301.24321060
29Base excision repair_Homo sapiens_hsa034100.99407529
30Vascular smooth muscle contraction_Homo sapiens_hsa042700.96953200
31Tryptophan metabolism_Homo sapiens_hsa003800.94302264
32Tyrosine metabolism_Homo sapiens_hsa003500.93581417
33Pyrimidine metabolism_Homo sapiens_hsa002400.92743917
34Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92541622
35Sulfur relay system_Homo sapiens_hsa041220.92072584
36Fanconi anemia pathway_Homo sapiens_hsa034600.91769071
37Primary immunodeficiency_Homo sapiens_hsa053400.90226250
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88282545
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88190264
40Chemical carcinogenesis_Homo sapiens_hsa052040.82806046
41Purine metabolism_Homo sapiens_hsa002300.79503553
42Serotonergic synapse_Homo sapiens_hsa047260.78978193
43Lysine degradation_Homo sapiens_hsa003100.76994744
44Primary bile acid biosynthesis_Homo sapiens_hsa001200.76378358
45Phenylalanine metabolism_Homo sapiens_hsa003600.76216811
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72830057
47Fatty acid biosynthesis_Homo sapiens_hsa000610.71095820
48Fatty acid degradation_Homo sapiens_hsa000710.70421046
49Caffeine metabolism_Homo sapiens_hsa002320.68014991
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67518134
51Cocaine addiction_Homo sapiens_hsa050300.66018682
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65761685
53Metabolic pathways_Homo sapiens_hsa011000.65170766
54Fatty acid elongation_Homo sapiens_hsa000620.62985229
55Selenocompound metabolism_Homo sapiens_hsa004500.62428654
56Long-term depression_Homo sapiens_hsa047300.61605592
57Sulfur metabolism_Homo sapiens_hsa009200.61404692
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.60977531
59Retinol metabolism_Homo sapiens_hsa008300.54945135
60Cell cycle_Homo sapiens_hsa041100.53527699
61Nucleotide excision repair_Homo sapiens_hsa034200.52822371
62Glycerolipid metabolism_Homo sapiens_hsa005610.51993219
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49098689
64Histidine metabolism_Homo sapiens_hsa003400.48791239
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46947590
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46491079
67ABC transporters_Homo sapiens_hsa020100.46167266
68Pancreatic secretion_Homo sapiens_hsa049720.42916763
69Systemic lupus erythematosus_Homo sapiens_hsa053220.41072832
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40118481
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.39470665
72Calcium signaling pathway_Homo sapiens_hsa040200.38179505
73Fatty acid metabolism_Homo sapiens_hsa012120.35870992
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.35758393
75VEGF signaling pathway_Homo sapiens_hsa043700.35370882
76Taste transduction_Homo sapiens_hsa047420.35360389
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33963124
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.33660219
79Peroxisome_Homo sapiens_hsa041460.31202948
80African trypanosomiasis_Homo sapiens_hsa051430.30391079
81Cholinergic synapse_Homo sapiens_hsa047250.30346085
82Mineral absorption_Homo sapiens_hsa049780.28677376
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26738199
84Vitamin B6 metabolism_Homo sapiens_hsa007500.26522015
85Renin-angiotensin system_Homo sapiens_hsa046140.24691740
86Spliceosome_Homo sapiens_hsa030400.24419140
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23899847
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23402775
89Bladder cancer_Homo sapiens_hsa052190.21228402
90Platelet activation_Homo sapiens_hsa046110.21076666
91Proteasome_Homo sapiens_hsa030500.20925488
92Inositol phosphate metabolism_Homo sapiens_hsa005620.19984693
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18277181
94Glutamatergic synapse_Homo sapiens_hsa047240.16205623
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.12861636
96Ras signaling pathway_Homo sapiens_hsa040140.11495285
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.10625972
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10298885
99TGF-beta signaling pathway_Homo sapiens_hsa043500.08145737
100Olfactory transduction_Homo sapiens_hsa047400.07563728

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