ZSWIM6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a zinc finger SWI2/SNF2 and MuDR (SWIM) domain. Proteins with SWIM domains have been found in a diverse number of species and are predicted to interact with DNA or proteins. Mutations in this gene result in acromelic frontonasal dysostosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.53435462
2central nervous system myelination (GO:0022010)4.53435462
3neuron cell-cell adhesion (GO:0007158)3.93843521
4pyrimidine nucleobase catabolic process (GO:0006208)3.76182362
5myelination (GO:0042552)3.71951907
6axon ensheathment (GO:0008366)3.70412009
7ensheathment of neurons (GO:0007272)3.70412009
8activated T cell proliferation (GO:0050798)3.64864760
9L-amino acid import (GO:0043092)3.57163443
10negative regulation of neurotransmitter secretion (GO:0046929)3.52510176
11Rap protein signal transduction (GO:0032486)3.40076002
12neuron recognition (GO:0008038)3.30175887
13negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.26430721
14dendritic spine morphogenesis (GO:0060997)3.26014255
15negative regulation of neurotransmitter transport (GO:0051589)3.23612909
16presynaptic membrane assembly (GO:0097105)3.22501376
17cerebral cortex radially oriented cell migration (GO:0021799)3.22293092
18limb bud formation (GO:0060174)3.19720833
19axonal fasciculation (GO:0007413)3.14946441
20dendrite morphogenesis (GO:0048813)3.13875779
21presynaptic membrane organization (GO:0097090)3.11514892
22locomotory exploration behavior (GO:0035641)3.09602097
23postsynaptic membrane organization (GO:0001941)3.09065290
24central nervous system neuron axonogenesis (GO:0021955)3.08240395
25amino acid import (GO:0043090)3.07664878
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.04710339
27transmission of nerve impulse (GO:0019226)2.99992953
28nerve growth factor signaling pathway (GO:0038180)2.98148981
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.91861410
30long-chain fatty acid biosynthetic process (GO:0042759)2.89934781
31regulation of dendritic spine morphogenesis (GO:0061001)2.85956250
32adenosine receptor signaling pathway (GO:0001973)2.85680664
33layer formation in cerebral cortex (GO:0021819)2.82040356
34neuronal action potential propagation (GO:0019227)2.81873489
35regulation of dendritic spine development (GO:0060998)2.75207197
36positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.73799526
37establishment of nucleus localization (GO:0040023)2.72399961
38myelination in peripheral nervous system (GO:0022011)2.71788598
39peripheral nervous system axon ensheathment (GO:0032292)2.71788598
40regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.71463732
41protein localization to endosome (GO:0036010)2.69651456
42semaphorin-plexin signaling pathway (GO:0071526)2.66604088
43negative regulation of axonogenesis (GO:0050771)2.63633425
44nucleobase catabolic process (GO:0046113)2.63436292
45regulation of collateral sprouting (GO:0048670)2.62873003
46regulation of axon regeneration (GO:0048679)2.61466286
47regulation of neuron projection regeneration (GO:0070570)2.61466286
48neuronal ion channel clustering (GO:0045161)2.61397378
49neuron remodeling (GO:0016322)2.61397331
50cell migration in hindbrain (GO:0021535)2.61233043
51regulation of NFAT protein import into nucleus (GO:0051532)2.60852740
52forebrain neuron differentiation (GO:0021879)2.59213174
53negative regulation of axon extension (GO:0030517)2.57890809
54glutamate receptor signaling pathway (GO:0007215)2.57403685
55detection of molecule of bacterial origin (GO:0032490)2.54958405
56protein localization to synapse (GO:0035418)2.54337783
57adult walking behavior (GO:0007628)2.51260411
58negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.49034248
59negative regulation of cell killing (GO:0031342)2.49034248
60olfactory bulb development (GO:0021772)2.48781488
61regulation of long-term neuronal synaptic plasticity (GO:0048169)2.48708354
62substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.47478824
63substrate-independent telencephalic tangential migration (GO:0021826)2.47478824
64negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.47409509
65negative regulation of translation, ncRNA-mediated (GO:0040033)2.47409509
66regulation of translation, ncRNA-mediated (GO:0045974)2.47409509
67Notch signaling involved in heart development (GO:0061314)2.45942403
68negative regulation of axon guidance (GO:1902668)2.45815426
69synaptic vesicle maturation (GO:0016188)2.44745483
70establishment of mitochondrion localization (GO:0051654)2.43806129
71cellular response to nerve growth factor stimulus (GO:1990090)2.42772355
72response to nerve growth factor (GO:1990089)2.42772355
73cytoplasmic mRNA processing body assembly (GO:0033962)2.42748017
74exploration behavior (GO:0035640)2.40965789
75vocalization behavior (GO:0071625)2.38953621
76central nervous system projection neuron axonogenesis (GO:0021952)2.38475036
77photoreceptor cell differentiation (GO:0046530)2.37502820
78eye photoreceptor cell differentiation (GO:0001754)2.37502820
79peptidyl-tyrosine autophosphorylation (GO:0038083)2.35560448
80prepulse inhibition (GO:0060134)2.35174556
81oligodendrocyte differentiation (GO:0048709)2.35172325
82microglial cell activation (GO:0001774)2.34018012
83asymmetric protein localization (GO:0008105)2.33098169
84ganglion development (GO:0061548)2.32845903
85negative regulation of axon extension involved in axon guidance (GO:0048843)2.32472599
86cyclic nucleotide catabolic process (GO:0009214)2.30297594
87regulation of short-term neuronal synaptic plasticity (GO:0048172)2.29265146
88axon extension (GO:0048675)2.29067702
89macrophage activation involved in immune response (GO:0002281)2.29035511
90regulation of synapse structural plasticity (GO:0051823)2.28584523
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.28360956
92regulation of fever generation (GO:0031620)2.28297083
93regulation of glutamate receptor signaling pathway (GO:1900449)2.28146282
94clathrin coat assembly (GO:0048268)2.27618083
95cerebral cortex cell migration (GO:0021795)2.27420857
96modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.26861510
97positive regulation by organism of defense response of other organism involved in symbiotic interact2.26861510
98modulation by symbiont of host immune response (GO:0052553)2.26861510
99positive regulation by symbiont of host defense response (GO:0052509)2.26861510
100modulation by symbiont of host defense response (GO:0052031)2.26861510
101modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.26861510
102import into cell (GO:0098657)2.26265162
103regulation of neuronal synaptic plasticity (GO:0048168)2.25663745
104regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.25280870
105fatty acid elongation (GO:0030497)2.24171954
106synaptic transmission, glutamatergic (GO:0035249)2.23586738
107gamma-aminobutyric acid signaling pathway (GO:0007214)2.23226116
108neuromuscular process controlling balance (GO:0050885)2.22671263
109regulation of voltage-gated calcium channel activity (GO:1901385)2.22573879
110cerebellar granule cell differentiation (GO:0021707)2.22138454
111positive regulation of dendritic spine development (GO:0060999)2.22058723
112regulation of synaptic vesicle exocytosis (GO:2000300)2.21960599
113response to peptidoglycan (GO:0032494)2.21614763
114negative chemotaxis (GO:0050919)2.21054124
115negative regulation of protein localization to cell surface (GO:2000009)2.20942882
116regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.20401748
117regulation of excitatory postsynaptic membrane potential (GO:0060079)2.20285052
118neuron-neuron synaptic transmission (GO:0007270)2.18879251
119phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.17625333
120gamma-aminobutyric acid transport (GO:0015812)2.17192110
121histone H3-K4 trimethylation (GO:0080182)2.16728897
122regulation of dendrite morphogenesis (GO:0048814)2.16691857
123embryonic retina morphogenesis in camera-type eye (GO:0060059)2.16536711
124positive regulation of synapse assembly (GO:0051965)2.15690975
125membrane assembly (GO:0071709)2.15158258
126positive regulation of neurological system process (GO:0031646)2.14644125
127negative regulation of dendrite development (GO:2000171)2.14541870
128auditory behavior (GO:0031223)2.14343384
129long-term memory (GO:0007616)2.13775299
130limb development (GO:0060173)2.13768428
131appendage development (GO:0048736)2.13768428
132mating behavior (GO:0007617)2.13633715
133regulation of axon extension involved in axon guidance (GO:0048841)2.13272065
134regulation of Rap GTPase activity (GO:0032317)2.13259365
135regulation of axon guidance (GO:1902667)2.12315715
136astrocyte development (GO:0014002)2.11880454
137apical protein localization (GO:0045176)2.11815915
138regulation of heat generation (GO:0031650)2.11646869
139telencephalon cell migration (GO:0022029)2.11565583
140cAMP catabolic process (GO:0006198)2.10223620
141negative regulation of oligodendrocyte differentiation (GO:0048715)2.09135121
142neuronal stem cell maintenance (GO:0097150)2.08515112
143neuron projection extension (GO:1990138)2.07978219
144neutrophil mediated immunity (GO:0002446)2.07072190
145negative regulation of vascular permeability (GO:0043116)2.06097540
146artery development (GO:0060840)2.04375623
147regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.03736130
148negative regulation of interleukin-12 production (GO:0032695)2.03678279
149heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.02644582
150regulation of axon extension (GO:0030516)2.02329261
151neuron projection extension involved in neuron projection guidance (GO:1902284)2.01789160
152axon extension involved in axon guidance (GO:0048846)2.01789160
153regulation of extent of cell growth (GO:0061387)2.01745133
154lens morphogenesis in camera-type eye (GO:0002089)2.01578319
155macrophage activation (GO:0042116)2.00047275
156cranial nerve morphogenesis (GO:0021602)1.99808918
157forebrain neuron development (GO:0021884)1.98519417
158neurotransmitter-gated ion channel clustering (GO:0072578)1.98170084
159myelin assembly (GO:0032288)1.97768336
160cellular extravasation (GO:0045123)1.96951597
161negative regulation of calcium ion-dependent exocytosis (GO:0045955)1.95914537
162cerebellar Purkinje cell differentiation (GO:0021702)1.95357154
163negative regulation of glial cell proliferation (GO:0060253)1.93551933
164regulation of chemokine-mediated signaling pathway (GO:0070099)1.92940012
165regulation of axonogenesis (GO:0050770)1.91816144
166neuroblast proliferation (GO:0007405)1.91541173
167embryonic viscerocranium morphogenesis (GO:0048703)1.91294740
168retinal ganglion cell axon guidance (GO:0031290)1.91008188

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.27857285
2GBX2_23144817_ChIP-Seq_PC3_Human3.06111150
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.39362528
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.33024503
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32094973
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.27062250
7AR_21572438_ChIP-Seq_LNCaP_Human2.15852815
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.13287993
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.11671994
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.08597467
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.08597467
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.06714267
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06062650
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.98073122
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97204258
16SALL1_21062744_ChIP-ChIP_HESCs_Human1.94454653
17SMAD_19615063_ChIP-ChIP_OVARY_Human1.94158640
18MTF2_20144788_ChIP-Seq_MESCs_Mouse1.87982134
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87320044
20* RNF2_27304074_Chip-Seq_ESCs_Mouse1.82338958
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80119068
22* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.79969360
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79100756
24DROSHA_22980978_ChIP-Seq_HELA_Human1.78090432
25TAF15_26573619_Chip-Seq_HEK293_Human1.78074821
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76448486
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74528890
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73870755
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.73183354
30* EZH2_27294783_Chip-Seq_ESCs_Mouse1.69820800
31* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67412447
32* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64982332
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61557385
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.59786554
35TP53_16413492_ChIP-PET_HCT116_Human1.53035168
36* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50518442
37P300_19829295_ChIP-Seq_ESCs_Human1.50048397
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.49949101
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.45919608
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.45904182
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45210100
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44678167
43AHR_22903824_ChIP-Seq_MCF-7_Human1.42632563
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.41947491
45* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41740407
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.40806779
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40759784
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.40421040
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38731408
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.38663471
51SMAD4_21799915_ChIP-Seq_A2780_Human1.36732387
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36197319
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35947605
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34863374
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34009068
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.32761707
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32613479
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31085181
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30856192
60CTNNB1_20460455_ChIP-Seq_HCT116_Human1.29161491
61* CJUN_26792858_Chip-Seq_BT549_Human1.27347759
62ER_23166858_ChIP-Seq_MCF-7_Human1.27180874
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26961049
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25561862
65* REST_21632747_ChIP-Seq_MESCs_Mouse1.24873266
66* RING1B_27294783_Chip-Seq_NPCs_Mouse1.23419193
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23403127
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22644572
69TP53_18474530_ChIP-ChIP_U2OS_Human1.22578820
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21806742
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21172148
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19970952
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19143760
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19015567
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17655838
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17655838
77* STAT3_23295773_ChIP-Seq_U87_Human1.17511695
78* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15361074
79CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15032637
80* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14741340
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.14159743
82* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12692485
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12486046
84FUS_26573619_Chip-Seq_HEK293_Human1.12315535
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.11913916
86RNF2_27304074_Chip-Seq_NSC_Mouse1.11120588
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10145582
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09548872
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09548872
90* VDR_24787735_ChIP-Seq_THP-1_Human1.09150173
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06533687
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06521148
93RXR_22108803_ChIP-Seq_LS180_Human1.06383441
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05289245
95* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05259768
96* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04856980
97ISL1_27105846_Chip-Seq_CPCs_Mouse1.04282892
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.03941504
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03791989
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03565267
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02983886
102* RING1B_27294783_Chip-Seq_ESCs_Mouse1.02313183
103KDM2B_26808549_Chip-Seq_REH_Human1.02291383
104IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01924385
105* TCF4_23295773_ChIP-Seq_U87_Human1.01688186
106FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01501464
107RUNX2_22187159_ChIP-Seq_PCA_Human1.01191126
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00629337
109BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00064643
110SMAD3_21741376_ChIP-Seq_HESCs_Human0.99585439
111FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99407340
112VDR_22108803_ChIP-Seq_LS180_Human0.99337924
113NANOG_18555785_Chip-Seq_ESCs_Mouse0.98828229
114AR_25329375_ChIP-Seq_VCAP_Human0.97967938
115BP1_19119308_ChIP-ChIP_Hs578T_Human0.97911223
116YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97742507
117ZNF274_21170338_ChIP-Seq_K562_Hela0.96177089
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96153276
119TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93488437
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92983730
121* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92942393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.26954770
2MP0004859_abnormal_synaptic_plasticity3.86056967
3MP0000920_abnormal_myelination3.34738719
4MP0004270_analgesia3.15874491
5MP0000778_abnormal_nervous_system2.69706813
6MP0001486_abnormal_startle_reflex2.59758549
7MP0003635_abnormal_synaptic_transmissio2.56835657
8MP0003690_abnormal_glial_cell2.43281611
9MP0005409_darkened_coat_color2.37389854
10MP0003828_pulmonary_edema2.34392018
11MP0004742_abnormal_vestibular_system2.32133306
12MP0002064_seizures2.24718879
13MP0003724_increased_susceptibility_to2.21590917
14MP0009745_abnormal_behavioral_response2.19555309
15MP0000569_abnormal_digit_pigmentation2.19266125
16MP0005423_abnormal_somatic_nervous2.18272219
17MP0002822_catalepsy2.17641057
18MP0005623_abnormal_meninges_morphology2.17185169
19MP0003303_peritoneal_inflammation2.13389293
20MP0002063_abnormal_learning/memory/cond2.12213638
21MP0005171_absent_coat_pigmentation2.07662247
22MP0009046_muscle_twitch1.93488410
23MP0002572_abnormal_emotion/affect_behav1.90049412
24MP0002272_abnormal_nervous_system1.80430301
25MP0001299_abnormal_eye_distance/1.78029487
26MP0003634_abnormal_glial_cell1.74895500
27MP0002734_abnormal_mechanical_nocicepti1.74024437
28MP0004885_abnormal_endolymph1.72196556
29MP0001440_abnormal_grooming_behavior1.63730426
30MP0004134_abnormal_chest_morphology1.46261566
31MP0001529_abnormal_vocalization1.45899401
32MP0001485_abnormal_pinna_reflex1.44758283
33MP0001968_abnormal_touch/_nociception1.41245356
34MP0002882_abnormal_neuron_morphology1.41083190
35MP0002653_abnormal_ependyma_morphology1.40885735
36MP0001879_abnormal_lymphatic_vessel1.39941551
37MP0004883_abnormal_blood_vessel1.39127885
38MP0005076_abnormal_cell_differentiation1.38397178
39MP0003385_abnormal_body_wall1.38176961
40MP0000955_abnormal_spinal_cord1.34348138
41MP0009053_abnormal_anal_canal1.33288089
42MP0003890_abnormal_embryonic-extraembry1.32743857
43MP0002067_abnormal_sensory_capabilities1.28296468
44MP0000428_abnormal_craniofacial_morphol1.28219012
45MP0001970_abnormal_pain_threshold1.26391913
46MP0002733_abnormal_thermal_nociception1.26074208
47MP0005187_abnormal_penis_morphology1.24434593
48MP0002184_abnormal_innervation1.23489045
49MP0003329_amyloid_beta_deposits1.23400749
50MP0005167_abnormal_blood-brain_barrier1.22550417
51MP0003632_abnormal_nervous_system1.21845867
52MP0004510_myositis1.21002930
53MP0002735_abnormal_chemical_nociception1.20728019
54MP0004811_abnormal_neuron_physiology1.19304202
55MP0003091_abnormal_cell_migration1.18729588
56MP0001905_abnormal_dopamine_level1.18125465
57MP0003935_abnormal_craniofacial_develop1.17940147
58MP0000465_gastrointestinal_hemorrhage1.17716416
59MP0006054_spinal_hemorrhage1.17441833
60MP0010352_gastrointestinal_tract_polyps1.16586828
61MP0008569_lethality_at_weaning1.16262475
62MP0008438_abnormal_cutaneous_collagen1.13606976
63MP0005164_abnormal_response_to1.13368659
64MP0003045_fibrosis1.12739600
65MP0005551_abnormal_eye_electrophysiolog1.10842239
66MP0005386_behavior/neurological_phenoty1.10571994
67MP0004924_abnormal_behavior1.10571994
68MP0002557_abnormal_social/conspecific_i1.10103300
69MP0000534_abnormal_ureter_morphology1.10042445
70MP0000767_abnormal_smooth_muscle1.09983556
71MP0000537_abnormal_urethra_morphology1.09507225
72MP0002152_abnormal_brain_morphology1.09034327
73MP0001177_atelectasis1.08702665
74MP0002066_abnormal_motor_capabilities/c1.08481558
75MP0005595_abnormal_vascular_smooth1.07906007
76MP0002896_abnormal_bone_mineralization1.06453952
77MP0002751_abnormal_autonomic_nervous1.06294661
78MP0000383_abnormal_hair_follicle1.05646013
79MP0001188_hyperpigmentation1.05137851
80MP0002229_neurodegeneration1.04664329
81MP0003633_abnormal_nervous_system1.04593911
82MP0001958_emphysema1.03741127
83MP0003631_nervous_system_phenotype1.03705309
84MP0001851_eye_inflammation1.03466890
85MP0003705_abnormal_hypodermis_morpholog1.01016472
86MP0003136_yellow_coat_color0.99180527
87MP0005174_abnormal_tail_pigmentation0.98895168
88MP0002752_abnormal_somatic_nervous0.98223975
89MP0002092_abnormal_eye_morphology0.95219762
90MP0001501_abnormal_sleep_pattern0.94893973
91MP0002009_preneoplasia0.94378723
92MP0000462_abnormal_digestive_system0.93682889
93MP0005195_abnormal_posterior_eye0.93426575
94MP0002736_abnormal_nociception_after0.92966358
95MP0001963_abnormal_hearing_physiology0.91254900
96MP0006082_CNS_inflammation0.90984220
97MP0010368_abnormal_lymphatic_system0.90867565
98MP0000432_abnormal_head_morphology0.90865631
99MP0004142_abnormal_muscle_tone0.90700003
100MP0002277_abnormal_respiratory_mucosa0.89432206
101MP0003950_abnormal_plasma_membrane0.88752985
102MP0002295_abnormal_pulmonary_circulatio0.88715662
103MP0002090_abnormal_vision0.87711651
104MP0003861_abnormal_nervous_system0.86594970
105MP0000604_amyloidosis0.86480776
106MP0004484_altered_response_of0.85761504
107MP0002081_perinatal_lethality0.84560477
108MP0002168_other_aberrant_phenotype0.84040614
109MP0009250_abnormal_appendicular_skeleto0.83801769
110MP0002233_abnormal_nose_morphology0.83742013
111MP0003938_abnormal_ear_development0.83021086
112MP0003937_abnormal_limbs/digits/tail_de0.81849856
113MP0000733_abnormal_muscle_development0.81695948
114MP0002282_abnormal_trachea_morphology0.80882271
115MP0003942_abnormal_urinary_system0.80834387
116MP0004272_abnormal_basement_membrane0.80184607
117MP0002419_abnormal_innate_immunity0.80183718
118MP0005248_abnormal_Harderian_gland0.80078093
119MP0003075_altered_response_to0.79251877
120MP0000516_abnormal_urinary_system0.78617090
121MP0005367_renal/urinary_system_phenotyp0.78617090
122MP0000427_abnormal_hair_cycle0.78325324
123MP0002116_abnormal_craniofacial_bone0.78275391
124MP0009384_cardiac_valve_regurgitation0.78126753
125MP0005410_abnormal_fertilization0.78062942
126MP0003279_aneurysm0.77406817
127MP0002133_abnormal_respiratory_system0.77141509
128MP0005388_respiratory_system_phenotype0.77141509
129MP0003787_abnormal_imprinting0.77015977
130MP0002925_abnormal_cardiovascular_devel0.76386170
131MP0009780_abnormal_chondrocyte_physiolo0.75845389
132MP0003300_gastrointestinal_ulcer0.74987689
133MP0006276_abnormal_autonomic_nervous0.74555907
134MP0003448_altered_tumor_morphology0.74105923
135MP0001915_intracranial_hemorrhage0.73798520
136MP0003172_abnormal_lysosome_physiology0.73584343
137MP0010678_abnormal_skin_adnexa0.72901313
138MP0003755_abnormal_palate_morphology0.72035847
139MP0001340_abnormal_eyelid_morphology0.71944995
140MP0001943_abnormal_respiration0.71062919
141MP0004858_abnormal_nervous_system0.65661682
142MP0001502_abnormal_circadian_rhythm0.64554829
143MP0001984_abnormal_olfaction0.63755983
144MP0002998_abnormal_bone_remodeling0.63713814
145MP0000026_abnormal_inner_ear0.63135897

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)3.96121616
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.94665904
3Degeneration of the lateral corticospinal tracts (HP:0002314)3.94665904
4Supranuclear gaze palsy (HP:0000605)3.46504385
5Abnormality of the corticospinal tract (HP:0002492)3.33537941
6Cerebral inclusion bodies (HP:0100314)3.29669544
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.15582257
8Short 4th metacarpal (HP:0010044)3.15582257
9Insidious onset (HP:0003587)3.05639511
10Termporal pattern (HP:0011008)3.05639511
11Peripheral hypomyelination (HP:0007182)2.84420354
12Hyperventilation (HP:0002883)2.83653118
13Papillary thyroid carcinoma (HP:0002895)2.73773285
14Myokymia (HP:0002411)2.73323984
15Sensory axonal neuropathy (HP:0003390)2.72313351
16Arterial tortuosity (HP:0005116)2.70149201
17Onion bulb formation (HP:0003383)2.62817272
18Vascular tortuosity (HP:0004948)2.55287808
19Focal seizures (HP:0007359)2.47883816
20Subacute progressive viral hepatitis (HP:0006572)2.45085908
21Abnormality of the ischium (HP:0003174)2.41056085
22Alacrima (HP:0000522)2.37619283
23Absent frontal sinuses (HP:0002688)2.34277892
24Broad-based gait (HP:0002136)2.29414513
25Widely spaced teeth (HP:0000687)2.28499763
26Abnormality of the 4th metacarpal (HP:0010012)2.26366016
27Broad ribs (HP:0000885)2.24365508
28Focal motor seizures (HP:0011153)2.23817443
29Abnormality of incisor morphology (HP:0011063)2.23776272
30Vitreoretinal degeneration (HP:0000655)2.23735122
31Dysmetria (HP:0001310)2.21127072
32Spastic gait (HP:0002064)2.20255246
33Mutism (HP:0002300)2.19818406
34Chin dimple (HP:0010751)2.19585453
35Obstructive sleep apnea (HP:0002870)2.18964646
36Hip dysplasia (HP:0001385)2.17684953
37Atonic seizures (HP:0010819)2.16612362
38Akinesia (HP:0002304)2.14790987
39Inappropriate behavior (HP:0000719)2.12372666
40Abnormality of the nasal septum (HP:0000419)2.09504552
41Curly hair (HP:0002212)2.09155355
42Aqueductal stenosis (HP:0002410)2.09142789
43Thickened helices (HP:0000391)2.08110521
44Disinhibition (HP:0000734)2.07869128
45Hypoplastic ischia (HP:0003175)2.07298627
46Ulnar claw (HP:0001178)2.05780553
47Action tremor (HP:0002345)2.05551612
48Hepatoblastoma (HP:0002884)2.05408224
49Drooling (HP:0002307)2.05230518
50Excessive salivation (HP:0003781)2.05230518
51Epiphyseal dysplasia (HP:0002656)2.04899518
52Clumsiness (HP:0002312)2.00406595
53Urinary bladder sphincter dysfunction (HP:0002839)1.98242465
54Scanning speech (HP:0002168)1.97586443
55Megalencephaly (HP:0001355)1.96130612
56Absent speech (HP:0001344)1.94256688
57Bowel incontinence (HP:0002607)1.93974098
58Abnormal large intestine physiology (HP:0012700)1.92664630
59Segmental peripheral demyelination/remyelination (HP:0003481)1.91051064
60Intention tremor (HP:0002080)1.90940915
61Decreased lacrimation (HP:0000633)1.90296505
62Relative macrocephaly (HP:0004482)1.90243952
63Narrow palate (HP:0000189)1.90195374
64Shallow orbits (HP:0000586)1.89498082
65Transitional cell carcinoma of the bladder (HP:0006740)1.88029847
66Parakeratosis (HP:0001036)1.85217138
67Large earlobe (HP:0009748)1.85196107
68Hypoplasia of the iris (HP:0007676)1.83836382
69Epileptic encephalopathy (HP:0200134)1.83759201
70Hematochezia (HP:0002573)1.83414115
71Spontaneous hematomas (HP:0007420)1.83189521
72Apathy (HP:0000741)1.82542085
73Gaze-evoked nystagmus (HP:0000640)1.82455526
74Progressive cerebellar ataxia (HP:0002073)1.81778187
75Bladder carcinoma (HP:0002862)1.81675645
76Bladder neoplasm (HP:0009725)1.81675645
77Pulmonic stenosis (HP:0001642)1.81427660
78Exotropia (HP:0000577)1.79379339
79Stereotypic behavior (HP:0000733)1.78476177
80Broad metatarsal (HP:0001783)1.78231137
81Lower limb amyotrophy (HP:0007210)1.77565814
82Febrile seizures (HP:0002373)1.77543008
83Heterotopia (HP:0002282)1.76304126
84Lower limb asymmetry (HP:0100559)1.75735144
85Dysdiadochokinesis (HP:0002075)1.74731797
86J-shaped sella turcica (HP:0002680)1.73029868
87Hypoplasia of the maxilla (HP:0000327)1.72837208
88Recurrent bacterial skin infections (HP:0005406)1.72714278
89Abnormality of the distal phalanx of the thumb (HP:0009617)1.71647715
90Decreased motor nerve conduction velocity (HP:0003431)1.71560599
91Slow saccadic eye movements (HP:0000514)1.70511190
92Disproportionate tall stature (HP:0001519)1.70206354
93Aplasia involving bones of the extremities (HP:0009825)1.69837064
94Aplasia involving bones of the upper limbs (HP:0009823)1.69837064
95Aplasia of the phalanges of the hand (HP:0009802)1.69837064
96Ankle clonus (HP:0011448)1.68990954
97Spondylolisthesis (HP:0003302)1.68568093
98Intellectual disability, moderate (HP:0002342)1.68566837
99Abnormality of salivation (HP:0100755)1.68285226
100Macroorchidism (HP:0000053)1.68239071
101Coronal craniosynostosis (HP:0004440)1.67851854
102Submucous cleft hard palate (HP:0000176)1.66244874
103Round face (HP:0000311)1.66175788
104Limb dystonia (HP:0002451)1.66110194
105Lower limb muscle weakness (HP:0007340)1.66038332
106Cupped ear (HP:0000378)1.66000212
107Neuronal loss in central nervous system (HP:0002529)1.65794971
108Steppage gait (HP:0003376)1.65630454
109Gastroesophageal reflux (HP:0002020)1.64863187
110Difficulty running (HP:0009046)1.64264643
111Stomatitis (HP:0010280)1.63865358
112Arnold-Chiari malformation (HP:0002308)1.63372358
113Cystic hygroma (HP:0000476)1.62208614
114Increased number of teeth (HP:0011069)1.62198397
115Short metatarsal (HP:0010743)1.62114441
116Abnormal auditory evoked potentials (HP:0006958)1.61870908
117Urinary urgency (HP:0000012)1.61407918
118Truncal obesity (HP:0001956)1.61200056
119Hypoplastic labia majora (HP:0000059)1.60988114
120Esophageal atresia (HP:0002032)1.60977223
121Overgrowth (HP:0001548)1.60623934
122Abnormality of binocular vision (HP:0011514)1.60377259
123Diplopia (HP:0000651)1.60377259
124Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.60372521
125Abnormality of the right ventricle (HP:0001707)1.60014524
126Vertebral arch anomaly (HP:0008438)1.59996713
127Bilateral sensorineural hearing impairment (HP:0008619)1.58913805
128Buphthalmos (HP:0000557)1.58460573
129Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.57767346
130Hammertoe (HP:0001765)1.57744981
131Truncal ataxia (HP:0002078)1.57537918
132Thyroid carcinoma (HP:0002890)1.57496845
133Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.56784985
134Abnormality of liposaccharide metabolism (HP:0010968)1.55804209
135Abnormality of glycosphingolipid metabolism (HP:0004343)1.55804209
136Abnormality of glycolipid metabolism (HP:0010969)1.55804209
137Abnormality of the parathyroid morphology (HP:0011766)1.55351330
138Preaxial foot polydactyly (HP:0001841)1.54718897
139Hemiparesis (HP:0001269)1.54682139
140Cutaneous finger syndactyly (HP:0010554)1.54275657
141Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.54167141
142Neoplasm of the heart (HP:0100544)1.53841902
143Syringomyelia (HP:0003396)1.53377135
144Spinal cord lesions (HP:0100561)1.53377135
145Choroideremia (HP:0001139)1.53268922
146Genetic anticipation (HP:0003743)1.51581911
147Papilledema (HP:0001085)1.50320663
148Retinal dysplasia (HP:0007973)1.50297262
149Laryngomalacia (HP:0001601)1.49485481
150Shawl scrotum (HP:0000049)1.48494134
1512-3 toe syndactyly (HP:0004691)1.48109254
152Peritonitis (HP:0002586)1.47044483
153Neonatal short-limb short stature (HP:0008921)1.46997464
154Neoplasm of the tracheobronchial system (HP:0100552)1.45440506
155Tapered finger (HP:0001182)1.45251003
156Long eyelashes (HP:0000527)1.45200779
157Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.45186944
158Abnormal vertebral ossification (HP:0100569)1.43676721
159Hemiplegia (HP:0002301)1.43526116
160Absent/shortened dynein arms (HP:0200106)1.43395325
161Dynein arm defect of respiratory motile cilia (HP:0012255)1.43395325
162Thick eyebrow (HP:0000574)1.42259317
163Hamartoma (HP:0010566)1.41774300
164Retrobulbar optic neuritis (HP:0100654)1.41699363
165Optic neuritis (HP:0100653)1.41699363
166Volvulus (HP:0002580)1.40998174

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.57383668
2EPHB13.30722736
3EPHA42.89288528
4MARK12.76996174
5TNIK2.36962760
6EPHB22.23122604
7FES2.14745288
8SGK22.06730322
9OXSR11.99003936
10PKN11.97845453
11PNCK1.85702652
12TYRO31.85685186
13MAP3K91.81803914
14NTRK31.78628148
15SIK21.75754103
16SGK31.71634971
17CASK1.66995862
18FGR1.64743418
19AKT31.58166726
20YES11.52370949
21FRK1.50835092
22ICK1.49842190
23NTRK11.49555410
24RIPK41.49428491
25CAMK1G1.47586057
26WNK11.44122639
27PRPF4B1.40194121
28MAP3K61.39869195
29PAK61.39391342
30CLK11.39145921
31ERBB31.36581485
32STK241.35235247
33MAPK131.30608149
34NTRK21.30395186
35DMPK1.25156668
36MAP3K41.23313753
37MAP2K41.22740859
38FGFR21.22557187
39IRAK21.22136328
40BCR1.18023313
41BLK1.15500302
42UHMK11.15234804
43CSNK1A1L1.14595440
44NEK61.11356132
45CDK51.11009233
46WNK41.11000635
47GRK71.08489458
48MARK21.07929094
49CSNK1G21.05870266
50PLK21.01741716
51MINK11.01065769
52STK110.98844765
53CAMK2B0.98116450
54PDGFRB0.96548104
55ROCK20.95481812
56PDGFRA0.93876742
57PTK2B0.92653339
58LATS20.92461253
59CSNK1G30.92045062
60KSR20.90033971
61PBK0.88980256
62IRAK10.87625835
63DYRK30.87207717
64FYN0.87074847
65ERBB20.85287252
66KSR10.84674937
67CSNK1G10.84384770
68BRD40.84123850
69PAK30.83717033
70SIK30.82675353
71EPHA30.82210303
72CSK0.80209649
73CAMK40.79522024
74NUAK10.78680706
75HCK0.78339723
76DYRK20.77635633
77CAMKK20.77611229
78PRKCQ0.74421140
79CDK140.73582628
80CAMK2D0.73477420
81MOS0.73356393
82MAP3K20.73114710
83CAMK2A0.72840105
84SGK2230.72092895
85SGK4940.72092895
86FER0.70343535
87NLK0.69431433
88MAP3K30.69152781
89DAPK20.68187962
90BMPR1B0.67756296
91ACVR1B0.65542346
92INSR0.64875222
93MAPK150.63438262
94TGFBR20.62888419
95SGK10.62016786
96TAOK10.61454241
97PRKCE0.60895305
98ALK0.60472983
99RET0.60149100
100MAPK70.59114978
101DDR20.58885226
102MAP3K70.58561977
103CAMK1D0.56401390
104TIE10.56227830
105DYRK1A0.55409942
106CHUK0.55360568
107CDK30.55021647
108PRKCH0.53922842
109CDK150.53784665
110FGFR10.52934204
111FGFR30.52921615
112MET0.52510436
113PRKG10.52129665
114MAP3K130.51885828
115BMPR20.51782600
116PRKCZ0.50157434
117CDK180.49984909
118GSK3A0.49946302
119RPS6KA20.49689161
120EGFR0.48029110
121MAP2K70.47216073
122CDK90.45771968
123TXK0.45670930
124CAMKK10.45281243
125MELK0.44876320
126CDK11A0.44483323
127CAMK10.43949418
128CSNK1D0.43683231
129MAPK100.43632577
130LCK0.43580578
131MAP2K30.43556175
132MKNK20.42864533
133ITK0.42238987
134MAP3K100.41990354
135IRAK40.41969176
136DYRK1B0.41869981
137JAK10.41730033
138ROCK10.40868267
139PDPK10.39842126
140PRKCG0.38117174
141MAP3K140.37327772

Predicted pathways (KEGG)

RankGene SetZ-score
1Axon guidance_Homo sapiens_hsa043602.07285913
2Glutamatergic synapse_Homo sapiens_hsa047241.67750008
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57471621
4Dorso-ventral axis formation_Homo sapiens_hsa043201.57145780
5Morphine addiction_Homo sapiens_hsa050321.51998808
6Nicotine addiction_Homo sapiens_hsa050331.50671774
7Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.49788340
8Olfactory transduction_Homo sapiens_hsa047401.48561925
9Long-term depression_Homo sapiens_hsa047301.47105548
10Cholinergic synapse_Homo sapiens_hsa047251.44644363
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43128390
12Serotonergic synapse_Homo sapiens_hsa047261.41321581
13Long-term potentiation_Homo sapiens_hsa047201.41079452
14Phototransduction_Homo sapiens_hsa047441.40877322
15Renal cell carcinoma_Homo sapiens_hsa052111.40770776
16Dopaminergic synapse_Homo sapiens_hsa047281.39271284
17Circadian entrainment_Homo sapiens_hsa047131.37913491
18Notch signaling pathway_Homo sapiens_hsa043301.36149922
19Cocaine addiction_Homo sapiens_hsa050301.36131175
20GABAergic synapse_Homo sapiens_hsa047271.36071212
21Renin secretion_Homo sapiens_hsa049241.32355014
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30931628
23Ether lipid metabolism_Homo sapiens_hsa005651.26374935
24Endometrial cancer_Homo sapiens_hsa052131.26264640
25Salivary secretion_Homo sapiens_hsa049701.24719719
26Steroid biosynthesis_Homo sapiens_hsa001001.24702649
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20007315
28ErbB signaling pathway_Homo sapiens_hsa040121.18006123
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15680987
30Amphetamine addiction_Homo sapiens_hsa050311.15633958
31Oxytocin signaling pathway_Homo sapiens_hsa049211.14800121
32TNF signaling pathway_Homo sapiens_hsa046681.13588593
33Prolactin signaling pathway_Homo sapiens_hsa049171.13190941
34Hedgehog signaling pathway_Homo sapiens_hsa043401.11168848
35Phospholipase D signaling pathway_Homo sapiens_hsa040721.09327337
36FoxO signaling pathway_Homo sapiens_hsa040681.09214447
37Sphingolipid signaling pathway_Homo sapiens_hsa040711.07765293
38Gap junction_Homo sapiens_hsa045401.06822763
39Chemokine signaling pathway_Homo sapiens_hsa040621.05113945
40Synaptic vesicle cycle_Homo sapiens_hsa047211.03773493
41Gastric acid secretion_Homo sapiens_hsa049711.02751281
42Osteoclast differentiation_Homo sapiens_hsa043801.00943207
43Ras signaling pathway_Homo sapiens_hsa040141.00781651
44Tuberculosis_Homo sapiens_hsa051521.00541102
45Glioma_Homo sapiens_hsa052141.00485308
46Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99857050
47Leishmaniasis_Homo sapiens_hsa051400.99404765
48Basal cell carcinoma_Homo sapiens_hsa052170.96461818
49T cell receptor signaling pathway_Homo sapiens_hsa046600.96225307
50GnRH signaling pathway_Homo sapiens_hsa049120.95574638
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95352210
52cAMP signaling pathway_Homo sapiens_hsa040240.94792406
53MAPK signaling pathway_Homo sapiens_hsa040100.93612400
54Choline metabolism in cancer_Homo sapiens_hsa052310.93171038
55B cell receptor signaling pathway_Homo sapiens_hsa046620.91722683
56Endocytosis_Homo sapiens_hsa041440.91717894
57Estrogen signaling pathway_Homo sapiens_hsa049150.91376100
58Type II diabetes mellitus_Homo sapiens_hsa049300.90985854
59Rap1 signaling pathway_Homo sapiens_hsa040150.90809597
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90571328
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90502147
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89439397
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89382285
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89235815
65Salmonella infection_Homo sapiens_hsa051320.88968437
66ECM-receptor interaction_Homo sapiens_hsa045120.88401037
67Focal adhesion_Homo sapiens_hsa045100.87852322
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86658097
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86610906
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85990785
71Legionellosis_Homo sapiens_hsa051340.84962560
72Inositol phosphate metabolism_Homo sapiens_hsa005620.84225932
73Calcium signaling pathway_Homo sapiens_hsa040200.83713874
74Rheumatoid arthritis_Homo sapiens_hsa053230.83351935
75Melanogenesis_Homo sapiens_hsa049160.82957164
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82627386
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82578555
78Non-small cell lung cancer_Homo sapiens_hsa052230.82110491
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82022398
80Platelet activation_Homo sapiens_hsa046110.81845789
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80628281
82Toxoplasmosis_Homo sapiens_hsa051450.79127394
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78905487
84African trypanosomiasis_Homo sapiens_hsa051430.78768662
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78726425
86Hepatitis B_Homo sapiens_hsa051610.78616757
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77955067
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.77897727
89Phagosome_Homo sapiens_hsa041450.77199665
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77031032
91VEGF signaling pathway_Homo sapiens_hsa043700.76565407
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76473396
93Malaria_Homo sapiens_hsa051440.75785486
94Wnt signaling pathway_Homo sapiens_hsa043100.74378450
95Proteoglycans in cancer_Homo sapiens_hsa052050.74373718
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.74240489
97Tight junction_Homo sapiens_hsa045300.74106112
98Pathways in cancer_Homo sapiens_hsa052000.73257783
99Acute myeloid leukemia_Homo sapiens_hsa052210.72897321
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72789072
101mTOR signaling pathway_Homo sapiens_hsa041500.72503152
102Adherens junction_Homo sapiens_hsa045200.72084675
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71858494
104MicroRNAs in cancer_Homo sapiens_hsa052060.71276561
105Sphingolipid metabolism_Homo sapiens_hsa006000.70775899
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70418401
107Dilated cardiomyopathy_Homo sapiens_hsa054140.70200626
108Amoebiasis_Homo sapiens_hsa051460.70084905
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69699518
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69258573
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68152197
112Pancreatic cancer_Homo sapiens_hsa052120.67608466
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.67459050
114Prion diseases_Homo sapiens_hsa050200.66948033
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66915416
116Influenza A_Homo sapiens_hsa051640.66816340
117Prostate cancer_Homo sapiens_hsa052150.66357177
118Colorectal cancer_Homo sapiens_hsa052100.66078434
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64360699
120Staphylococcus aureus infection_Homo sapiens_hsa051500.64196746
121Taste transduction_Homo sapiens_hsa047420.63925558
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63741348
123Viral myocarditis_Homo sapiens_hsa054160.63203574
124Chronic myeloid leukemia_Homo sapiens_hsa052200.62674379
125Hippo signaling pathway_Homo sapiens_hsa043900.61161581
126TGF-beta signaling pathway_Homo sapiens_hsa043500.61131256
127Pertussis_Homo sapiens_hsa051330.60696667

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