ZSWIM7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.28448262
2proteasome assembly (GO:0043248)4.98210658
3behavioral response to nicotine (GO:0035095)4.47814489
4respiratory chain complex IV assembly (GO:0008535)4.44924391
5ribosomal small subunit assembly (GO:0000028)4.43231988
6protein neddylation (GO:0045116)4.40611501
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.38434053
8deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.33806499
9platelet dense granule organization (GO:0060155)4.11570172
10ATP synthesis coupled proton transport (GO:0015986)4.09416233
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.09416233
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.00076849
13cytochrome complex assembly (GO:0017004)3.95179502
14oxidative phosphorylation (GO:0006119)3.92556179
15tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.91081214
16RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.91081214
17L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.90205960
18regulation of cellular amino acid metabolic process (GO:0006521)3.81601879
19DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.79073525
20regulation of mitochondrial translation (GO:0070129)3.78963486
21signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.74215112
22intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.74215112
23signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.71195458
24signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.71195458
25signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.71195458
26positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.69965453
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.69342859
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.68864960
29negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.68809552
30negative regulation of ligase activity (GO:0051352)3.68809552
31water-soluble vitamin biosynthetic process (GO:0042364)3.67050422
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.64935398
33telomere maintenance via semi-conservative replication (GO:0032201)3.64797980
34signal transduction involved in DNA damage checkpoint (GO:0072422)3.62675572
35signal transduction involved in DNA integrity checkpoint (GO:0072401)3.62675572
36anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.61078892
37formation of translation preinitiation complex (GO:0001731)3.60490875
38nucleobase-containing small molecule interconversion (GO:0015949)3.58701714
39cullin deneddylation (GO:0010388)3.58301294
40nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.57020940
41signal transduction involved in cell cycle checkpoint (GO:0072395)3.56052405
42protein deneddylation (GO:0000338)3.55020178
43DNA strand elongation involved in DNA replication (GO:0006271)3.51653368
44pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.50411957
45exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.49732523
46pseudouridine synthesis (GO:0001522)3.49274534
47respiratory electron transport chain (GO:0022904)3.48724694
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.47816240
49antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.44189771
50establishment of protein localization to mitochondrion (GO:0072655)3.40849185
51electron transport chain (GO:0022900)3.40217698
52protein targeting to mitochondrion (GO:0006626)3.37866928
53telomere maintenance via recombination (GO:0000722)3.36844833
547-methylguanosine mRNA capping (GO:0006370)3.36830154
55mitochondrial respiratory chain complex I assembly (GO:0032981)3.36326556
56NADH dehydrogenase complex assembly (GO:0010257)3.36326556
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.36326556
58RNA capping (GO:0036260)3.35425430
597-methylguanosine RNA capping (GO:0009452)3.35425430
60DNA replication initiation (GO:0006270)3.35127912
61regulation of cilium movement (GO:0003352)3.34071232
62deoxyribose phosphate biosynthetic process (GO:0046385)3.31612277
632-deoxyribonucleotide biosynthetic process (GO:0009265)3.31612277
64maturation of SSU-rRNA (GO:0030490)3.30733757
65rRNA modification (GO:0000154)3.28950154
66ubiquinone biosynthetic process (GO:0006744)3.28946741
67response to pheromone (GO:0019236)3.28690829
68transcription elongation from RNA polymerase III promoter (GO:0006385)3.28247584
69termination of RNA polymerase III transcription (GO:0006386)3.28247584
70mitochondrial respiratory chain complex assembly (GO:0033108)3.27407187
71positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.27097520
72L-methionine biosynthetic process (GO:0071265)3.26424788
73amino acid salvage (GO:0043102)3.26424788
74L-methionine salvage (GO:0071267)3.26424788
75DNA strand elongation (GO:0022616)3.26300435
76protein complex biogenesis (GO:0070271)3.25672227
77protein-cofactor linkage (GO:0018065)3.20545981
78pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.20355695
79pteridine-containing compound biosynthetic process (GO:0042559)3.20170031
80protein localization to mitochondrion (GO:0070585)3.18870309
81GDP-mannose metabolic process (GO:0019673)3.18543180
82positive regulation of ligase activity (GO:0051351)3.15751351
83tRNA methylation (GO:0030488)3.12142967
84ribosome biogenesis (GO:0042254)3.11051278
85guanosine-containing compound biosynthetic process (GO:1901070)3.09632154
86viral mRNA export from host cell nucleus (GO:0046784)3.08887452
87ubiquinone metabolic process (GO:0006743)3.08712284
88epithelial cilium movement (GO:0003351)3.07683437
89transcription-coupled nucleotide-excision repair (GO:0006283)3.07112365
90epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.06973135
91ribosomal small subunit biogenesis (GO:0042274)3.06290090
92hydrogen ion transmembrane transport (GO:1902600)3.05445460
93nucleobase biosynthetic process (GO:0046112)3.04484697
94translation (GO:0006412)3.03605914
95ribonucleoprotein complex biogenesis (GO:0022613)3.03054406
96GTP biosynthetic process (GO:0006183)3.01347210
97sequestering of actin monomers (GO:0042989)3.01210936
98deoxyribonucleotide biosynthetic process (GO:0009263)3.00601430
99mitotic recombination (GO:0006312)2.99587758
100spliceosomal snRNP assembly (GO:0000387)2.99171102
101peptidyl-histidine modification (GO:0018202)2.98981703
102regulation of ubiquitin-protein transferase activity (GO:0051438)2.98299169
103detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.97241907
104ATP biosynthetic process (GO:0006754)2.96570244
105DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.95515772
106pyrimidine nucleotide catabolic process (GO:0006244)2.95447123
107folic acid-containing compound biosynthetic process (GO:0009396)2.94557076
108purine nucleobase biosynthetic process (GO:0009113)2.94429265
109cellular component biogenesis (GO:0044085)2.93996204
110positive regulation of mitochondrial fission (GO:0090141)2.93874287
111proton transport (GO:0015992)2.93333334
112DNA replication checkpoint (GO:0000076)2.92452559
113kynurenine metabolic process (GO:0070189)2.90067399
114regulation of ligase activity (GO:0051340)2.90024042
115nonmotile primary cilium assembly (GO:0035058)2.89887408
116positive regulation of cell cycle arrest (GO:0071158)2.89775853
117tryptophan catabolic process (GO:0006569)2.89157162
118indole-containing compound catabolic process (GO:0042436)2.89157162
119indolalkylamine catabolic process (GO:0046218)2.89157162
120transcription from RNA polymerase I promoter (GO:0006360)2.88388424
121fucose catabolic process (GO:0019317)2.87532501
122L-fucose metabolic process (GO:0042354)2.87532501
123L-fucose catabolic process (GO:0042355)2.87532501
124hydrogen transport (GO:0006818)2.87462763
125chromatin remodeling at centromere (GO:0031055)2.87069284
126mitochondrial DNA replication (GO:0006264)2.86507218
127CENP-A containing nucleosome assembly (GO:0034080)2.85953873
128amine catabolic process (GO:0009310)2.85310330
129cellular biogenic amine catabolic process (GO:0042402)2.85310330
130antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.85128210
131SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.84362037
132regulation of cellular amine metabolic process (GO:0033238)2.83853194
133chaperone-mediated protein transport (GO:0072321)2.83226069
134intracellular protein transmembrane import (GO:0044743)2.79980467
135purine nucleoside triphosphate biosynthetic process (GO:0009145)2.79146937
136purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.78742069
137anterograde synaptic vesicle transport (GO:0048490)2.72566180
138preassembly of GPI anchor in ER membrane (GO:0016254)2.70834868
139cellular ketone body metabolic process (GO:0046950)2.69556151
140negative regulation of telomere maintenance (GO:0032205)2.67744837
141axoneme assembly (GO:0035082)2.67227250
142dopamine transport (GO:0015872)2.65968897
143protein polyglutamylation (GO:0018095)2.65116104
144cilium morphogenesis (GO:0060271)2.64675400
145DNA double-strand break processing (GO:0000729)2.63056394
146male meiosis I (GO:0007141)2.63014755
147indolalkylamine metabolic process (GO:0006586)2.62119520
148mannosylation (GO:0097502)2.62010375
149base-excision repair, AP site formation (GO:0006285)2.61769686
150negative regulation of response to food (GO:0032096)2.61333065
151negative regulation of appetite (GO:0032099)2.61333065
152protein localization to cilium (GO:0061512)2.60852527
153replication fork processing (GO:0031297)2.58595884
154tRNA processing (GO:0008033)2.55325048
155quinone biosynthetic process (GO:1901663)2.51352786
156regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.50692847
157regulation of mitotic spindle checkpoint (GO:1903504)2.50692847
158GPI anchor metabolic process (GO:0006505)2.50617716
159piRNA metabolic process (GO:0034587)2.50355623
160maturation of 5.8S rRNA (GO:0000460)2.50111844
161viral transcription (GO:0019083)2.49862897
162translational termination (GO:0006415)2.49226169
163tryptophan metabolic process (GO:0006568)2.49188951
164intraciliary transport (GO:0042073)2.46608343
165ketone body metabolic process (GO:1902224)2.43931414
166DNA damage response, detection of DNA damage (GO:0042769)2.41679659
167reciprocal meiotic recombination (GO:0007131)2.39794039
168reciprocal DNA recombination (GO:0035825)2.39794039
169negative regulation of transcription regulatory region DNA binding (GO:2000678)2.39343054
170meiosis I (GO:0007127)2.37834819

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.31964886
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.09793574
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.90117492
4E2F7_22180533_ChIP-Seq_HELA_Human3.89305042
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.87730195
6ZNF274_21170338_ChIP-Seq_K562_Hela3.70954746
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53686156
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.48606754
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.42739726
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.35367597
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.24578960
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.23322053
13VDR_22108803_ChIP-Seq_LS180_Human3.10298337
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.07643738
15EZH2_22144423_ChIP-Seq_EOC_Human2.90024114
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82280695
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78594297
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.70349737
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58658638
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.55140440
21VDR_23849224_ChIP-Seq_CD4+_Human2.50980014
22E2F1_18555785_ChIP-Seq_MESCs_Mouse2.48488409
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39370456
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.39349884
25IGF1R_20145208_ChIP-Seq_DFB_Human2.36031703
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.30810343
27DCP1A_22483619_ChIP-Seq_HELA_Human2.30399269
28XRN2_22483619_ChIP-Seq_HELA_Human2.29338746
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27033529
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24201658
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.22936435
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21983605
33EWS_26573619_Chip-Seq_HEK293_Human2.20032515
34YY1_21170310_ChIP-Seq_MESCs_Mouse2.18718405
35ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16558503
36FOXP3_21729870_ChIP-Seq_TREG_Human2.05835119
37FUS_26573619_Chip-Seq_HEK293_Human2.05549943
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05106135
39E2F4_17652178_ChIP-ChIP_JURKAT_Human2.04604757
40GABP_19822575_ChIP-Seq_HepG2_Human2.04174874
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97899992
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97853159
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94840856
44* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92220712
45GBX2_23144817_ChIP-Seq_PC3_Human1.92128730
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91843218
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.91368385
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83422065
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81330382
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78088565
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77704238
52ELK1_19687146_ChIP-ChIP_HELA_Human1.75148508
53* TTF2_22483619_ChIP-Seq_HELA_Human1.74957251
54P300_19829295_ChIP-Seq_ESCs_Human1.74393288
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74363316
56TAF15_26573619_Chip-Seq_HEK293_Human1.72761893
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72062597
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71235987
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70025647
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68863957
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67486487
62TP53_22573176_ChIP-Seq_HFKS_Human1.64798075
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63947460
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63312894
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.60665569
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55930692
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51806318
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50601426
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47979341
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47177866
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46979767
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.43242516
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42656117
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41001892
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40510872
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40417400
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36657784
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.35719244
79FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35719244
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35402529
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.34306717
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32754942
83NANOG_19829295_ChIP-Seq_ESCs_Human1.30929495
84SOX2_19829295_ChIP-Seq_ESCs_Human1.30929495
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30375018
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30358438
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28648652
88ER_23166858_ChIP-Seq_MCF-7_Human1.28388661
89* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26221030
90AR_21909140_ChIP-Seq_LNCAP_Human1.25823628
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.25231125
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.24967764
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24520177
94RNF2_27304074_Chip-Seq_NSC_Mouse1.22051935
95AR_20517297_ChIP-Seq_VCAP_Human1.21737727
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21380052
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20684136
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20649067
99* ELK1_22589737_ChIP-Seq_MCF10A_Human1.19629916
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19231021
101CBP_20019798_ChIP-Seq_JUKART_Human1.19231021
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.18167254
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16942420
104BCAT_22108803_ChIP-Seq_LS180_Human1.16932968
105IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16690166
106MYC_18940864_ChIP-ChIP_HL60_Human1.14421008
107CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12837489
108KDM5A_27292631_Chip-Seq_BREAST_Human1.12755598
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12559791
110NCOR_22424771_ChIP-Seq_293T_Human1.12019525
111E2F1_21310950_ChIP-Seq_MCF-7_Human1.09802340
112ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09748053
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08074673
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08074673
115PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06831423
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05156350
117* AR_25329375_ChIP-Seq_VCAP_Human1.04951736
118SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04814902
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04231112
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03683681
121TCF4_22108803_ChIP-Seq_LS180_Human1.03629277
122HTT_18923047_ChIP-ChIP_STHdh_Human1.03288046
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02372439
124FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02181834
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01481561
126REST_21632747_ChIP-Seq_MESCs_Mouse1.00261928
127* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99858629
128TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99156920
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98771583
130ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98679339
131GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98654769
132SMAD4_21799915_ChIP-Seq_A2780_Human0.98398420
133DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96993277
134HOXB7_26014856_ChIP-Seq_BT474_Human0.96643321
135NANOG_20526341_ChIP-Seq_ESCs_Human0.96041238
136FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95928068
137PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95705756
138CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95461902
139SOX2_16153702_ChIP-ChIP_HESCs_Human0.95110239
140CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94786611
141AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94403251
142KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94260988
143NFE2_27457419_Chip-Seq_LIVER_Mouse0.93534729
144SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93491916
145TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92539926
146TFEB_21752829_ChIP-Seq_HELA_Human0.92515626
147* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92413401
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92395334
149FOXH1_21741376_ChIP-Seq_EPCs_Human0.91980855
150AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91916052
151EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91402362
152SMAD4_21741376_ChIP-Seq_EPCs_Human0.91354407
153MYC_19829295_ChIP-Seq_ESCs_Human0.90841380
154EZH2_27294783_Chip-Seq_NPCs_Mouse0.90253250
155SMAD3_21741376_ChIP-Seq_EPCs_Human0.89885265
156RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87641924
157PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.87463687
158SOX17_20123909_ChIP-Seq_XEN_Mouse0.84394495
159FOXM1_23109430_ChIP-Seq_U2OS_Human0.83881086
160CIITA_25753668_ChIP-Seq_RAJI_Human0.83693786
161SPI1_23547873_ChIP-Seq_NB4_Human0.83539914
162KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82894071
163KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.82894071
164KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.82894071
165CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82231350
166IRF1_19129219_ChIP-ChIP_H3396_Human0.80846783
167SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80414308
168YY1_22570637_ChIP-Seq_MALME-3M_Human0.80143303
169TBX5_21415370_ChIP-Seq_HL-1_Mouse0.79971015
170ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.78293962
171IRF8_22096565_ChIP-ChIP_GC-B_Human0.77673094

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.71347038
2MP0006292_abnormal_olfactory_placode4.28836410
3MP0003693_abnormal_embryo_hatching4.12964887
4MP0003646_muscle_fatigue3.67125041
5MP0003186_abnormal_redox_activity3.47335866
6MP0004957_abnormal_blastocyst_morpholog3.44917407
7MP0009697_abnormal_copulation3.30543885
8MP0006036_abnormal_mitochondrial_physio3.02088768
9MP0010094_abnormal_chromosome_stability2.69022188
10MP0008058_abnormal_DNA_repair2.58359534
11MP0003718_maternal_effect2.56496288
12MP0008877_abnormal_DNA_methylation2.42742458
13MP0000749_muscle_degeneration2.39309731
14MP0008932_abnormal_embryonic_tissue2.34149584
15MP0003195_calcinosis2.28986660
16MP0003077_abnormal_cell_cycle2.26710699
17MP0003123_paternal_imprinting2.22196895
18MP0006035_abnormal_mitochondrial_morpho2.21086313
19MP0002102_abnormal_ear_morphology2.17311473
20MP0002653_abnormal_ependyma_morphology2.14770041
21MP0003011_delayed_dark_adaptation2.14193862
22MP0001968_abnormal_touch/_nociception2.11898685
23MP0006072_abnormal_retinal_apoptosis2.11589995
24MP0003787_abnormal_imprinting2.09503495
25MP0008057_abnormal_DNA_replication2.08640876
26MP0003880_abnormal_central_pattern2.06793336
27MP0008007_abnormal_cellular_replicative2.03910967
28MP0005551_abnormal_eye_electrophysiolog2.02852332
29MP0002736_abnormal_nociception_after2.02186724
30MP0004142_abnormal_muscle_tone1.98281580
31MP0003111_abnormal_nucleus_morphology1.88183568
32MP0006276_abnormal_autonomic_nervous1.87595499
33MP0008789_abnormal_olfactory_epithelium1.80541347
34MP0008872_abnormal_physiological_respon1.71458406
35MP0002938_white_spotting1.70552365
36MP0005253_abnormal_eye_physiology1.63488362
37MP0005645_abnormal_hypothalamus_physiol1.60022435
38MP0005410_abnormal_fertilization1.59904395
39MP0004510_myositis1.59577811
40MP0004043_abnormal_pH_regulation1.59481161
41MP0001485_abnormal_pinna_reflex1.55351345
42MP0002210_abnormal_sex_determination1.55298717
43MP0005646_abnormal_pituitary_gland1.53801956
44MP0009745_abnormal_behavioral_response1.53036687
45MP0002272_abnormal_nervous_system1.52436502
46MP0005266_abnormal_metabolism1.51377532
47MP0005408_hypopigmentation1.50885197
48MP0009046_muscle_twitch1.50868585
49MP0001929_abnormal_gametogenesis1.49898268
50MP0003786_premature_aging1.47602838
51MP0000631_abnormal_neuroendocrine_gland1.47451716
52MP0001764_abnormal_homeostasis1.42354113
53MP0003656_abnormal_erythrocyte_physiolo1.37978230
54MP0001986_abnormal_taste_sensitivity1.37476220
55MP0005174_abnormal_tail_pigmentation1.37094359
56MP0004885_abnormal_endolymph1.35357342
57MP0003121_genomic_imprinting1.33736527
58MP0003890_abnormal_embryonic-extraembry1.33228708
59MP0005332_abnormal_amino_acid1.30852018
60MP0000358_abnormal_cell_content/1.30650894
61MP0001145_abnormal_male_reproductive1.30142957
62MP0002234_abnormal_pharynx_morphology1.28011712
63MP0002139_abnormal_hepatobiliary_system1.23031800
64MP0005394_taste/olfaction_phenotype1.22566729
65MP0005499_abnormal_olfactory_system1.22566729
66MP0005671_abnormal_response_to1.21160714
67MP0002095_abnormal_skin_pigmentation1.20954256
68MP0001486_abnormal_startle_reflex1.20609831
69MP0002277_abnormal_respiratory_mucosa1.19378497
70MP0009333_abnormal_splenocyte_physiolog1.19206833
71MP0000569_abnormal_digit_pigmentation1.18718296
72MP0000653_abnormal_sex_gland1.16377967
73MP0002572_abnormal_emotion/affect_behav1.15269037
74MP0001730_embryonic_growth_arrest1.15032666
75MP0002269_muscular_atrophy1.14896635
76MP0001970_abnormal_pain_threshold1.14891787
77MP0001984_abnormal_olfaction1.14183919
78MP0000678_abnormal_parathyroid_gland1.14082460
79MP0005319_abnormal_enzyme/_coenzyme1.13999032
80MP0001293_anophthalmia1.13028983
81MP0009840_abnormal_foam_cell1.12204024
82MP0005360_urolithiasis1.11111192
83MP0001835_abnormal_antigen_presentation1.10734720
84MP0002733_abnormal_thermal_nociception1.10500395
85MP0002837_dystrophic_cardiac_calcinosis1.07163984
86MP0002163_abnormal_gland_morphology1.06487443
87MP0002557_abnormal_social/conspecific_i1.06394442
88MP0002160_abnormal_reproductive_system1.05958859
89MP0004036_abnormal_muscle_relaxation1.05887596
90MP0008995_early_reproductive_senescence1.05267280
91MP0005084_abnormal_gallbladder_morpholo1.04136310
92MP0009785_altered_susceptibility_to1.03846170
93MP0005636_abnormal_mineral_homeostasis1.03362943
94MP0004133_heterotaxia1.03298015
95MP0004147_increased_porphyrin_level1.02909744
96MP0000427_abnormal_hair_cycle1.02744053
97MP0001853_heart_inflammation1.02296257
98MP0002735_abnormal_chemical_nociception1.01830517
99MP0002148_abnormal_hypersensitivity_rea1.01376118
100MP0008260_abnormal_autophagy0.99890182
101MP0002067_abnormal_sensory_capabilities0.99200825
102MP0000647_abnormal_sebaceous_gland0.97934806
103MP0002928_abnormal_bile_duct0.97816244
104MP0000313_abnormal_cell_death0.97314935
105MP0004742_abnormal_vestibular_system0.97292199
106MP0002638_abnormal_pupillary_reflex0.97212893
107MP0003136_yellow_coat_color0.97145556
108MP0005075_abnormal_melanosome_morpholog0.97058124
109MP0002064_seizures0.96899526
110MP0005389_reproductive_system_phenotype0.96686678
111MP0005195_abnormal_posterior_eye0.96639361
112MP0003698_abnormal_male_reproductive0.94399352
113MP0003567_abnormal_fetal_cardiomyocyte0.93163927
114MP0002876_abnormal_thyroid_physiology0.93038626
115MP0004145_abnormal_muscle_electrophysio0.92750096
116MP0004215_abnormal_myocardial_fiber0.92658882
117MP0000026_abnormal_inner_ear0.92258545
118MP0005085_abnormal_gallbladder_physiolo0.90888150
119MP0008875_abnormal_xenobiotic_pharmacok0.89303191
120MP0003119_abnormal_digestive_system0.88689082
121MP0001697_abnormal_embryo_size0.88581038
122MP0000566_synostosis0.88231557
123MP0003283_abnormal_digestive_organ0.87919188
124MP0005376_homeostasis/metabolism_phenot0.87650805
125MP0003122_maternal_imprinting0.86912211
126MP0004084_abnormal_cardiac_muscle0.86247932
127MP0000778_abnormal_nervous_system0.86075619
128MP0000230_abnormal_systemic_arterial0.84985410
129MP0005365_abnormal_bile_salt0.84296086
130MP0001119_abnormal_female_reproductive0.83123830
131MP0000490_abnormal_crypts_of0.83068080
132MP0005395_other_phenotype0.82974406
133MP0002752_abnormal_somatic_nervous0.82692566
134MP0002734_abnormal_mechanical_nocicepti0.82301869
135MP0003221_abnormal_cardiomyocyte_apopto0.82217797
136MP0001324_abnormal_eye_pigmentation0.82085492
137MP0005377_hearing/vestibular/ear_phenot0.81527613
138MP0003878_abnormal_ear_physiology0.81527613
139MP0009643_abnormal_urine_homeostasis0.81338028
140MP0000350_abnormal_cell_proliferation0.80007327
141MP0000049_abnormal_middle_ear0.79979148
142MP0002106_abnormal_muscle_physiology0.79338948
143MP0000372_irregular_coat_pigmentation0.78658042
144MP0008469_abnormal_protein_level0.78630823
145MP0000343_altered_response_to0.78229618
146MP0002019_abnormal_tumor_incidence0.77350143
147MP0002080_prenatal_lethality0.72670048
148MP0001529_abnormal_vocalization0.72514388
149MP0005379_endocrine/exocrine_gland_phen0.71278762
150MP0000750_abnormal_muscle_regeneration0.71217231
151MP0005330_cardiomyopathy0.69888137
152MP0000689_abnormal_spleen_morphology0.68624908
153MP0005584_abnormal_enzyme/coenzyme_acti0.65006611
154MP0002161_abnormal_fertility/fecundity0.64932721
155MP0002332_abnormal_exercise_endurance0.64399336
156MP0001919_abnormal_reproductive_system0.63408124
157MP0004233_abnormal_muscle_weight0.62270197
158MP0003315_abnormal_perineum_morphology0.62043676
159MP0002693_abnormal_pancreas_physiology0.60717755
160MP0001905_abnormal_dopamine_level0.60013252
161MP0002722_abnormal_immune_system0.59868073
162MP0005000_abnormal_immune_tolerance0.59812270
163MP0009379_abnormal_foot_pigmentation0.59552980

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.12701333
2Hepatocellular necrosis (HP:0001404)4.81062230
3Hepatic necrosis (HP:0002605)4.79997484
4Abnormal mitochondria in muscle tissue (HP:0008316)4.56511052
5Mitochondrial inheritance (HP:0001427)4.54781994
6Acute encephalopathy (HP:0006846)4.36570837
7Increased CSF lactate (HP:0002490)4.11228308
8Pancreatic cysts (HP:0001737)4.07291865
9Molar tooth sign on MRI (HP:0002419)4.01608216
10Abnormality of midbrain morphology (HP:0002418)4.01608216
113-Methylglutaconic aciduria (HP:0003535)3.97706483
12Progressive macrocephaly (HP:0004481)3.93310319
13Pancreatic fibrosis (HP:0100732)3.88280074
14True hermaphroditism (HP:0010459)3.84954194
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.77923341
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.77923341
17Nephronophthisis (HP:0000090)3.42878333
18Increased serum lactate (HP:0002151)3.41442440
19Lactic acidosis (HP:0003128)3.38294631
20Microvesicular hepatic steatosis (HP:0001414)3.36707359
21Cerebral edema (HP:0002181)3.34977021
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.32983807
23Generalized aminoaciduria (HP:0002909)3.30044598
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.27508401
25Metaphyseal dysplasia (HP:0100255)3.26425758
26Congenital stationary night blindness (HP:0007642)3.08273063
27Abnormality of cells of the erythroid lineage (HP:0012130)3.07993343
28Respiratory failure (HP:0002878)3.06779236
29Exercise intolerance (HP:0003546)3.06389247
30Increased serum pyruvate (HP:0003542)3.04351039
31Abnormality of glycolysis (HP:0004366)3.04351039
32Abnormal number of erythroid precursors (HP:0012131)3.03650057
33Birth length less than 3rd percentile (HP:0003561)3.02071547
34Breast hypoplasia (HP:0003187)3.01997280
35Congenital, generalized hypertrichosis (HP:0004540)3.00240054
36Cerebral hypomyelination (HP:0006808)2.91925123
37Medial flaring of the eyebrow (HP:0010747)2.91762847
38Abnormality of aromatic amino acid family metabolism (HP:0004338)2.86939776
39Abnormality of the renal medulla (HP:0100957)2.82907544
40Lipid accumulation in hepatocytes (HP:0006561)2.76264568
41Type I transferrin isoform profile (HP:0003642)2.75913221
42Aplastic anemia (HP:0001915)2.71902971
43Carpal bone hypoplasia (HP:0001498)2.68699297
44CNS demyelination (HP:0007305)2.63717262
45Dicarboxylic aciduria (HP:0003215)2.63222288
46Abnormality of dicarboxylic acid metabolism (HP:0010995)2.63222288
47Increased hepatocellular lipid droplets (HP:0006565)2.59493668
48Lethargy (HP:0001254)2.52808358
49Sclerocornea (HP:0000647)2.52479400
50Progressive external ophthalmoplegia (HP:0000590)2.50599933
51Abnormality of alanine metabolism (HP:0010916)2.50504509
52Hyperalaninemia (HP:0003348)2.50504509
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.50504509
54Abolished electroretinogram (ERG) (HP:0000550)2.50392115
55Emotional lability (HP:0000712)2.49649508
56Optic disc pallor (HP:0000543)2.49118770
57Abnormality of the renal cortex (HP:0011035)2.47633975
58Chronic hepatic failure (HP:0100626)2.47573602
59Hypoglycemic coma (HP:0001325)2.47379386
60Abnormality of the anterior horn cell (HP:0006802)2.46261769
61Degeneration of anterior horn cells (HP:0002398)2.46261769
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.44723788
63Reticulocytopenia (HP:0001896)2.40686203
64Nausea (HP:0002018)2.40299817
65Leukodystrophy (HP:0002415)2.38933376
66Methylmalonic acidemia (HP:0002912)2.37357264
67Exertional dyspnea (HP:0002875)2.35146078
68Pendular nystagmus (HP:0012043)2.33451232
69Anencephaly (HP:0002323)2.33405274
70Abnormality of the labia minora (HP:0012880)2.31295250
71Gait imbalance (HP:0002141)2.30847653
72Cystic liver disease (HP:0006706)2.30357716
73Congenital primary aphakia (HP:0007707)2.29965603
74Abnormal rod and cone electroretinograms (HP:0008323)2.26577928
75Abnormality of fatty-acid metabolism (HP:0004359)2.26422057
76Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.24904302
77Oral leukoplakia (HP:0002745)2.24470158
78Increased intramyocellular lipid droplets (HP:0012240)2.23447832
79Hyperglycinemia (HP:0002154)2.22883550
80Rough bone trabeculation (HP:0100670)2.22749443
81Aplasia/Hypoplasia of the tongue (HP:0010295)2.22545657
82Renal Fanconi syndrome (HP:0001994)2.22529778
83Attenuation of retinal blood vessels (HP:0007843)2.22523119
84Macrocytic anemia (HP:0001972)2.21137547
85Microretrognathia (HP:0000308)2.21056907
86Abnormal biliary tract physiology (HP:0012439)2.21019609
87Bile duct proliferation (HP:0001408)2.21019609
88Septo-optic dysplasia (HP:0100842)2.20925692
89Male pseudohermaphroditism (HP:0000037)2.19792872
90Colon cancer (HP:0003003)2.18443630
91Increased muscle lipid content (HP:0009058)2.17443338
92Methylmalonic aciduria (HP:0012120)2.16432688
93Nephrogenic diabetes insipidus (HP:0009806)2.16050405
94Postaxial foot polydactyly (HP:0001830)2.11182461
95Abnormal spermatogenesis (HP:0008669)2.08727328
96Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08526016
97Postnatal microcephaly (HP:0005484)2.07908525
98Type 2 muscle fiber atrophy (HP:0003554)2.07539121
99Pancytopenia (HP:0001876)2.06911479
100Renal cortical cysts (HP:0000803)2.05259921
101Brushfield spots (HP:0001088)2.05086758
102Type II lissencephaly (HP:0007260)2.03910858
103Muscle fiber atrophy (HP:0100295)2.02952943
104Rhabdomyolysis (HP:0003201)2.01094049
105Decreased central vision (HP:0007663)2.00162887
106Optic nerve hypoplasia (HP:0000609)1.99473529
107Abnormal respiratory motile cilium morphology (HP:0005938)1.99226542
108Abnormal respiratory epithelium morphology (HP:0012253)1.99226542
109Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99046086
110Large for gestational age (HP:0001520)1.98973948
111Progressive muscle weakness (HP:0003323)1.98953715
112Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97526277
113Hyperglycinuria (HP:0003108)1.96777050
114Congenital hepatic fibrosis (HP:0002612)1.96060633
115Abnormal drinking behavior (HP:0030082)1.95507384
116Polydipsia (HP:0001959)1.95507384
117Agnosia (HP:0010524)1.94566323
118Secondary amenorrhea (HP:0000869)1.93117921
119Aplasia/Hypoplasia of the tibia (HP:0005772)1.90800405
120Genital tract atresia (HP:0001827)1.90451796
121Unsteady gait (HP:0002317)1.90366601
122Glycosuria (HP:0003076)1.89830091
123Abnormality of urine glucose concentration (HP:0011016)1.89830091
124Prolonged neonatal jaundice (HP:0006579)1.89421573
125Abnormal protein N-linked glycosylation (HP:0012347)1.89078299
126Abnormal protein glycosylation (HP:0012346)1.89078299
127Abnormal glycosylation (HP:0012345)1.89078299
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89078299
129Furrowed tongue (HP:0000221)1.87328020
130Polyphagia (HP:0002591)1.86819995
131Vaginal atresia (HP:0000148)1.86593034
132Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.85830123
133Megaloblastic anemia (HP:0001889)1.85604227
134Aplasia/hypoplasia of the uterus (HP:0008684)1.84988754
135Abnormality of pyrimidine metabolism (HP:0004353)1.84302323
136Gliosis (HP:0002171)1.83623329
137Myoglobinuria (HP:0002913)1.83433894
138Dynein arm defect of respiratory motile cilia (HP:0012255)1.83284670
139Absent/shortened dynein arms (HP:0200106)1.83284670
140Irregular epiphyses (HP:0010582)1.83037396
141Concave nail (HP:0001598)1.82666661
142Abnormality of glycine metabolism (HP:0010895)1.80045293
143Abnormality of serine family amino acid metabolism (HP:0010894)1.80045293
144Premature graying of hair (HP:0002216)1.79775760
145Hyperventilation (HP:0002883)1.78287537
146Anophthalmia (HP:0000528)1.77196493
147Abnormal ciliary motility (HP:0012262)1.76299715
148Female pseudohermaphroditism (HP:0010458)1.76176439
149Petechiae (HP:0000967)1.75498950
150Abnormal trabecular bone morphology (HP:0100671)1.75067373
151Short tibia (HP:0005736)1.73610270
152Hypobetalipoproteinemia (HP:0003563)1.73471578
153Postaxial hand polydactyly (HP:0001162)1.73413649
154Proximal tubulopathy (HP:0000114)1.73348133
155Lissencephaly (HP:0001339)1.72112867
156Poor suck (HP:0002033)1.71713433
157Ketosis (HP:0001946)1.71016122
158Hyperphosphaturia (HP:0003109)1.70890765
159Adrenal hypoplasia (HP:0000835)1.70842120
160Preaxial hand polydactyly (HP:0001177)1.68366977
161Personality changes (HP:0000751)1.67737073
162Multiple enchondromatosis (HP:0005701)1.66899619
163Premature ovarian failure (HP:0008209)1.66840119
164Delusions (HP:0000746)1.66832227
165Respiratory difficulties (HP:0002880)1.66179774
166Trismus (HP:0000211)1.64917311
167External ophthalmoplegia (HP:0000544)1.63402709
168Increased IgM level (HP:0003496)1.62990077
169Ragged-red muscle fibers (HP:0003200)1.62691692

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.37656054
2BUB14.31854444
3NME23.67128184
4WEE13.21530672
5PLK43.13694495
6EIF2AK12.89230938
7BMPR1B2.86209520
8FRK2.83819695
9ADRBK22.71373927
10VRK22.61882126
11NUAK12.54363123
12EIF2AK32.50230343
13MAP4K22.35335906
14BRSK22.22628632
15BCKDK2.21504834
16GRK12.16325568
17IRAK32.14342547
18NME12.05823011
19VRK12.05037829
20MUSK2.03102342
21TSSK61.91968973
22BRAF1.85113039
23WNK41.84038137
24ZAK1.83218337
25ARAF1.79593262
26NEK11.74442085
27FLT31.74231719
28MAP3K41.71231284
29PIM21.63017710
30TAOK31.57764371
31INSRR1.57505346
32STK38L1.57128939
33CDK191.55231576
34PDK31.54921160
35PDK41.54921160
36CDC71.51601985
37SRPK11.50803908
38TESK21.49850140
39PBK1.46738047
40EPHA21.46600647
41PINK11.43797979
42OXSR11.42922354
43MAP2K71.40538276
44TRIM281.37782896
45PASK1.35696071
46PNCK1.35247113
47MST41.34836075
48MAPK131.30797199
49PDK21.29962927
50STK391.28713236
51NEK91.27784302
52TESK11.26326654
53CDK81.26055327
54CSNK1G21.22237998
55TXK1.21905416
56CDK71.19276436
57BRSK11.17972707
58CSNK1G31.14694252
59MKNK21.12913105
60AURKA1.07265877
61CSNK1G11.06728500
62PLK21.01418471
63NEK21.01343873
64PLK11.00739546
65ACVR1B1.00317495
66MAP3K111.00105708
67STK240.99411760
68TGFBR10.99039734
69ADRBK10.97978568
70SIK30.96813230
71PHKG20.96297761
72PHKG10.96297761
73PRKCG0.94509325
74ABL20.93549338
75TIE10.92205238
76OBSCN0.91243313
77ATR0.87552911
78TTK0.87527974
79PRKCE0.86735509
80MAP3K120.84836666
81CSNK1A1L0.82939564
82TNIK0.82756393
83TAF10.81943204
84MAP3K80.81520984
85MKNK10.81100819
86DYRK30.78940565
87PAK30.78098844
88MAP3K30.76261895
89AURKB0.75883087
90DAPK20.73097411
91CAMKK20.72603653
92IKBKB0.69037613
93LIMK10.68116378
94PLK30.68003961
95PTK2B0.67686063
96TLK10.67129647
97NLK0.64200681
98PIM10.63413024
99RPS6KB20.63382495
100WNK30.63156751
101ERBB30.62425505
102PRKG20.59988573
103BMPR20.59393508
104TEC0.59366558
105CSNK2A10.59287338
106CCNB10.57359146
107RPS6KA40.55976439
108IRAK10.54530660
109DYRK20.53832682
110CASK0.51618933
111EPHA40.50586706
112CAMK2A0.50573858
113JAK30.50467492
114IRAK40.50112249
115PRKCQ0.49318222
116CDK30.49271203
117BCR0.49258656
118PRKACA0.48800042
119PIK3CG0.48252680
120MAP3K140.48244188
121MYLK0.47827966
122CSNK2A20.46966176
123EIF2AK20.46871839
124MARK30.46536704
125PAK10.43982818
126PKN10.43546660
127NEK60.43480284
128GRK50.43087187
129DAPK30.41996728
130PIK3CA0.41833481
131STK40.40909014
132MARK10.40174069
133ILK0.39864026
134MAPK150.39759261
135EPHB20.38894464
136CHEK20.38406086
137CAMK10.38220125
138NTRK20.38123444
139CSNK1A10.38103226
140TAOK20.37142144
141BRD40.36553600
142PRKG10.35594338
143MINK10.35175503
144MAP2K60.34478723
145MOS0.34074747
146PRKCA0.34018032
147KDR0.33052773
148BTK0.32961003
149PRKCI0.32847962
150CHEK10.32344600
151RPS6KA60.32232415
152MET0.31990185
153MAPKAPK30.31538212
154RPS6KL10.31116738
155RPS6KC10.31116738
156PAK40.29452853
157MAP2K30.27630963
158RPS6KA50.27283500

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.46172596
2Ribosome_Homo sapiens_hsa030103.44410379
3DNA replication_Homo sapiens_hsa030303.44405280
4Oxidative phosphorylation_Homo sapiens_hsa001903.34527793
5RNA polymerase_Homo sapiens_hsa030203.10931747
6Parkinsons disease_Homo sapiens_hsa050122.99763057
7Mismatch repair_Homo sapiens_hsa034302.87331345
8Pyrimidine metabolism_Homo sapiens_hsa002402.64859469
9Protein export_Homo sapiens_hsa030602.64154165
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.58688585
11Homologous recombination_Homo sapiens_hsa034402.40597843
12Huntingtons disease_Homo sapiens_hsa050162.35579744
13Phototransduction_Homo sapiens_hsa047442.08742989
14Nucleotide excision repair_Homo sapiens_hsa034202.07897744
15Folate biosynthesis_Homo sapiens_hsa007902.06648723
16Alzheimers disease_Homo sapiens_hsa050101.96804635
17Basal transcription factors_Homo sapiens_hsa030221.94793188
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.87597514
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.84520446
20Base excision repair_Homo sapiens_hsa034101.84308414
21Spliceosome_Homo sapiens_hsa030401.84159305
22RNA transport_Homo sapiens_hsa030131.80069452
23Nitrogen metabolism_Homo sapiens_hsa009101.73057293
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66954381
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66008652
26Butanoate metabolism_Homo sapiens_hsa006501.60353000
27RNA degradation_Homo sapiens_hsa030181.56303352
28Non-homologous end-joining_Homo sapiens_hsa034501.51040874
29One carbon pool by folate_Homo sapiens_hsa006701.46874304
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46666682
31Purine metabolism_Homo sapiens_hsa002301.44994103
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.37541153
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33972269
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31912947
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31543555
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30545647
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.18778258
38Fructose and mannose metabolism_Homo sapiens_hsa000511.18369571
39Caffeine metabolism_Homo sapiens_hsa002321.15495099
40Nicotine addiction_Homo sapiens_hsa050331.12474253
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12195694
42Glutathione metabolism_Homo sapiens_hsa004801.11699984
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11629340
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10950669
45Fanconi anemia pathway_Homo sapiens_hsa034601.06665479
46Cell cycle_Homo sapiens_hsa041101.06306358
47Carbon metabolism_Homo sapiens_hsa012001.03927837
48Pyruvate metabolism_Homo sapiens_hsa006201.02817731
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99614405
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96640740
51Pentose phosphate pathway_Homo sapiens_hsa000300.95150552
52Ether lipid metabolism_Homo sapiens_hsa005650.94287161
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.94233724
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93669801
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90933502
56Sulfur relay system_Homo sapiens_hsa041220.89029800
57Sulfur metabolism_Homo sapiens_hsa009200.88750520
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88568614
59Olfactory transduction_Homo sapiens_hsa047400.87999106
60Propanoate metabolism_Homo sapiens_hsa006400.87125825
61Peroxisome_Homo sapiens_hsa041460.87073418
62Metabolic pathways_Homo sapiens_hsa011000.86436774
63Biosynthesis of amino acids_Homo sapiens_hsa012300.86034207
64Asthma_Homo sapiens_hsa053100.84123740
65Fatty acid elongation_Homo sapiens_hsa000620.83807519
66Selenocompound metabolism_Homo sapiens_hsa004500.79816481
67Cardiac muscle contraction_Homo sapiens_hsa042600.78847620
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.77701529
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77460463
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74992917
71Taste transduction_Homo sapiens_hsa047420.74389756
72Retinol metabolism_Homo sapiens_hsa008300.73956062
73Galactose metabolism_Homo sapiens_hsa000520.73872574
74Epstein-Barr virus infection_Homo sapiens_hsa051690.73081374
75beta-Alanine metabolism_Homo sapiens_hsa004100.72936483
76Morphine addiction_Homo sapiens_hsa050320.69366549
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69331937
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.68012949
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66784664
80Steroid biosynthesis_Homo sapiens_hsa001000.65135008
81Legionellosis_Homo sapiens_hsa051340.63509127
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62490505
83Serotonergic synapse_Homo sapiens_hsa047260.60449313
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60141658
85Arachidonic acid metabolism_Homo sapiens_hsa005900.58806675
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57969715
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57290263
88Linoleic acid metabolism_Homo sapiens_hsa005910.57030690
89Antigen processing and presentation_Homo sapiens_hsa046120.55813507
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54703544
91Chemical carcinogenesis_Homo sapiens_hsa052040.54323781
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53438626
93Arginine and proline metabolism_Homo sapiens_hsa003300.53412599
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52790402
95GABAergic synapse_Homo sapiens_hsa047270.50778553
96p53 signaling pathway_Homo sapiens_hsa041150.48745818
97Fatty acid degradation_Homo sapiens_hsa000710.48114153
98Phenylalanine metabolism_Homo sapiens_hsa003600.44332853
99Fat digestion and absorption_Homo sapiens_hsa049750.42947965
100Regulation of autophagy_Homo sapiens_hsa041400.42197258
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42038328
102Collecting duct acid secretion_Homo sapiens_hsa049660.41981354
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41550120
104Primary immunodeficiency_Homo sapiens_hsa053400.39478476
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38704691
106Type I diabetes mellitus_Homo sapiens_hsa049400.38127531
107Other glycan degradation_Homo sapiens_hsa005110.38001823
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37853077
109Circadian entrainment_Homo sapiens_hsa047130.36989080
110Insulin secretion_Homo sapiens_hsa049110.35999200
111Tyrosine metabolism_Homo sapiens_hsa003500.35066192
112Vibrio cholerae infection_Homo sapiens_hsa051100.34421190
113Vitamin B6 metabolism_Homo sapiens_hsa007500.33831757
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31285901
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.30459593
116Herpes simplex infection_Homo sapiens_hsa051680.30218517
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29677989
118Glycerolipid metabolism_Homo sapiens_hsa005610.29071249
119Tryptophan metabolism_Homo sapiens_hsa003800.27666531
120Vitamin digestion and absorption_Homo sapiens_hsa049770.27643785
121Thyroid cancer_Homo sapiens_hsa052160.27495054
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27045029
123mRNA surveillance pathway_Homo sapiens_hsa030150.26535092
124Rheumatoid arthritis_Homo sapiens_hsa053230.26370064
125Mineral absorption_Homo sapiens_hsa049780.24384280
126Oocyte meiosis_Homo sapiens_hsa041140.24247230
127Allograft rejection_Homo sapiens_hsa053300.22713382
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20462636
129Starch and sucrose metabolism_Homo sapiens_hsa005000.19691857
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.17815470
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17729836
132Fatty acid metabolism_Homo sapiens_hsa012120.16694309

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