ZSWIM8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mannose metabolic process (GO:0006013)4.03317774
2negative regulation of erythrocyte differentiation (GO:0045647)3.84912455
3cytoskeletal anchoring at plasma membrane (GO:0007016)3.70196550
4sodium ion export (GO:0071436)3.41972002
5plasma membrane repair (GO:0001778)3.28965811
6locomotory exploration behavior (GO:0035641)3.22204344
7establishment of nucleus localization (GO:0040023)3.18040091
8layer formation in cerebral cortex (GO:0021819)3.11418258
9insulin-like growth factor receptor signaling pathway (GO:0048009)3.09622577
10synaptic vesicle maturation (GO:0016188)3.04399960
11regulation of ARF protein signal transduction (GO:0032012)2.94453941
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.91230481
13regulation of NFAT protein import into nucleus (GO:0051532)2.90394950
14negative regulation of cell size (GO:0045792)2.86207718
15regulation of short-term neuronal synaptic plasticity (GO:0048172)2.80826701
16stress fiber assembly (GO:0043149)2.79937681
17macroautophagy (GO:0016236)2.79581175
18cell communication by electrical coupling (GO:0010644)2.79353987
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.78122417
20negative regulation of cell killing (GO:0031342)2.77896710
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.77896710
22negative regulation of fatty acid transport (GO:2000192)2.75947782
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.74486719
24synaptic vesicle docking involved in exocytosis (GO:0016081)2.72831591
25regulation of clathrin-mediated endocytosis (GO:2000369)2.71535814
26positive regulation of histone deacetylation (GO:0031065)2.70433203
27apoptotic cell clearance (GO:0043277)2.69966619
28cytoplasmic mRNA processing body assembly (GO:0033962)2.66786197
29dendrite morphogenesis (GO:0048813)2.65694353
30endothelial cell chemotaxis (GO:0035767)2.64196928
31positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.63925983
32regulation of ARF GTPase activity (GO:0032312)2.63905193
33regulation of extracellular matrix disassembly (GO:0010715)2.61126939
34semaphorin-plexin signaling pathway (GO:0071526)2.60653176
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.60395162
36axon extension involved in axon guidance (GO:0048846)2.60304836
37neuron projection extension involved in neuron projection guidance (GO:1902284)2.60304836
38activation of protein kinase A activity (GO:0034199)2.60133654
39histone H3-K36 demethylation (GO:0070544)2.59402829
40negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.58300298
41regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.56147294
42positive regulation of glycogen biosynthetic process (GO:0045725)2.55984858
43adherens junction assembly (GO:0034333)2.55904123
44protein localization to endosome (GO:0036010)2.54944427
45detection of other organism (GO:0098543)2.54916534
46regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.54719229
47germinal center formation (GO:0002467)2.53660490
48cellular potassium ion homeostasis (GO:0030007)2.53274699
49positive regulation of gamma-delta T cell activation (GO:0046645)2.53072716
50response to muramyl dipeptide (GO:0032495)2.52634491
51macrophage activation involved in immune response (GO:0002281)2.51034934
52detection of bacterium (GO:0016045)2.50558159
53detection of molecule of bacterial origin (GO:0032490)2.49724165
54positive regulation of receptor recycling (GO:0001921)2.49425311
55antigen processing and presentation of endogenous antigen (GO:0019883)2.47470903
56response to laminar fluid shear stress (GO:0034616)2.47393166
57cell-cell junction maintenance (GO:0045217)2.47244752
58peptidyl-lysine dimethylation (GO:0018027)2.46078409
59glial cell proliferation (GO:0014009)2.45329502
60positive regulation by symbiont of host defense response (GO:0052509)2.45248229
61modulation by symbiont of host defense response (GO:0052031)2.45248229
62modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.45248229
63modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.45248229
64positive regulation by organism of defense response of other organism involved in symbiotic interact2.45248229
65modulation by symbiont of host immune response (GO:0052553)2.45248229
66cerebellar Purkinje cell layer development (GO:0021680)2.44861448
67detection of external biotic stimulus (GO:0098581)2.44089355
68regulation of p38MAPK cascade (GO:1900744)2.42408310
69positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.41591044
70cerebellar Purkinje cell differentiation (GO:0021702)2.40871325
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.40516670
72positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.39198543
73regulation of synapse structural plasticity (GO:0051823)2.34205128
74regulation of gamma-delta T cell activation (GO:0046643)2.33094271
75regulation of T-helper 2 cell differentiation (GO:0045628)2.32906522
76barbed-end actin filament capping (GO:0051016)2.31871747
77stress granule assembly (GO:0034063)2.31636269
78response to peptidoglycan (GO:0032494)2.30456562
79positive regulation of Cdc42 GTPase activity (GO:0043089)2.29947445
80signal complex assembly (GO:0007172)2.28210857
81positive regulation of fibroblast migration (GO:0010763)2.28193126
82activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.27543380
83cell-substrate junction assembly (GO:0007044)2.26737447
84antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.25590474
85epithelial cell differentiation involved in prostate gland development (GO:0060742)2.24838446
86positive regulation of Rap GTPase activity (GO:0032854)2.23501469
87cell migration in hindbrain (GO:0021535)2.22205003
88thymic T cell selection (GO:0045061)2.22155978
89cortical actin cytoskeleton organization (GO:0030866)2.21902026
90alanine transport (GO:0032328)2.21138868
91regulation of leukocyte degranulation (GO:0043300)2.20731013
92proline transport (GO:0015824)2.18584046
93neuromuscular process controlling balance (GO:0050885)2.18366935
94clathrin coat assembly (GO:0048268)2.17052699
95positive regulation of axon extension (GO:0045773)2.16901873
96cell adhesion mediated by integrin (GO:0033627)2.16363772
97vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.16336278
98NLS-bearing protein import into nucleus (GO:0006607)2.16290537
99positive regulation of p38MAPK cascade (GO:1900745)2.15873159
100nerve growth factor signaling pathway (GO:0038180)2.15669310
101positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.15488480
102axon extension (GO:0048675)2.15204100
103regulation of fatty acid beta-oxidation (GO:0031998)2.14863188
104positive regulation of blood vessel endothelial cell migration (GO:0043536)2.14846238
105positive regulation of glycogen metabolic process (GO:0070875)2.14616601
106negative regulation of catenin import into nucleus (GO:0035414)2.14347208
107positive regulation of cellular amide metabolic process (GO:0034250)2.14248786
108peptidyl-tyrosine autophosphorylation (GO:0038083)2.13671027
109cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.12886056
110cell-substrate adherens junction assembly (GO:0007045)2.12294883
111focal adhesion assembly (GO:0048041)2.12294883
112protein targeting to plasma membrane (GO:0072661)2.12138258
113detection of biotic stimulus (GO:0009595)2.12088033
114regulation of myeloid leukocyte mediated immunity (GO:0002886)2.11941655
115regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.11785772
116cell volume homeostasis (GO:0006884)2.11653733
117basement membrane organization (GO:0071711)2.11523351
118regulation of gamma-delta T cell differentiation (GO:0045586)2.11299239
119negative regulation of toll-like receptor signaling pathway (GO:0034122)2.11017448
120COPI coating of Golgi vesicle (GO:0048205)2.10911259
121Golgi transport vesicle coating (GO:0048200)2.10911259
122regulation of early endosome to late endosome transport (GO:2000641)2.10886551
123positive thymic T cell selection (GO:0045059)2.10076016
124planar cell polarity pathway involved in neural tube closure (GO:0090179)2.09523417
125dendritic spine morphogenesis (GO:0060997)2.08922266
126positive regulation of nuclease activity (GO:0032075)2.08636379
127regulation of interferon-beta biosynthetic process (GO:0045357)2.07943455
128endodermal cell differentiation (GO:0035987)2.07854429
129positive regulation of extracellular matrix organization (GO:1903055)2.07457870
130potassium ion import (GO:0010107)2.07436677
131response to fluid shear stress (GO:0034405)2.07131512
132heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.07108975
133establishment of protein localization to Golgi (GO:0072600)2.06594333
134positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.06232362
135protein heterotrimerization (GO:0070208)2.05762263
136heart morphogenesis (GO:0003007)2.05620658
137regulation of histone H3-K27 methylation (GO:0061085)2.05056277
138cellular sodium ion homeostasis (GO:0006883)2.04944250
139glucocorticoid receptor signaling pathway (GO:0042921)2.04627608
140positive regulation of protein deacetylation (GO:0090312)2.04176293
141vascular endothelial growth factor signaling pathway (GO:0038084)2.03776372
142regulation of axon extension involved in axon guidance (GO:0048841)2.03405645
143regulation of cholesterol homeostasis (GO:2000188)2.03378541
144cell communication involved in cardiac conduction (GO:0086065)2.03180111
145gastrulation with mouth forming second (GO:0001702)2.03030019
146regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.02485755
147regulation of glucose import in response to insulin stimulus (GO:2001273)2.02191638
148regulation of extracellular matrix organization (GO:1903053)2.02137026
149receptor catabolic process (GO:0032801)2.01525916
150heparan sulfate proteoglycan metabolic process (GO:0030201)2.01339491
151hippo signaling (GO:0035329)2.00326088
152embryonic foregut morphogenesis (GO:0048617)1.99903770
153negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)1.99196337
154positive regulation of protein kinase C signaling (GO:0090037)1.98566132
155exploration behavior (GO:0035640)1.98377503
156regulation of macrophage cytokine production (GO:0010935)1.98038903
157nucleus localization (GO:0051647)1.97961067
158negative regulation of myotube differentiation (GO:0010832)1.97784307
159negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)1.97404266
160skin morphogenesis (GO:0043589)1.97376613
161histone H3-K9 demethylation (GO:0033169)1.97288447
162regulation of polysaccharide biosynthetic process (GO:0032885)1.97054198
163cardiac myofibril assembly (GO:0055003)1.96120902
164histone lysine demethylation (GO:0070076)1.95885563
165regulation of glutamate receptor signaling pathway (GO:1900449)1.95877293
166regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act1.95787581
167axonal fasciculation (GO:0007413)1.95428202
168activation of JUN kinase activity (GO:0007257)1.94882447
169embryonic process involved in female pregnancy (GO:0060136)1.94769541
170adherens junction organization (GO:0034332)1.94540655
171cell migration involved in sprouting angiogenesis (GO:0002042)1.94516818
172glutamate secretion (GO:0014047)1.94471354
173lipopolysaccharide-mediated signaling pathway (GO:0031663)1.92583013
174regulation of lipid kinase activity (GO:0043550)1.90259351
175regulation of necroptotic process (GO:0060544)1.89591648
176regulation of mast cell degranulation (GO:0043304)1.89355839
177response to type I interferon (GO:0034340)1.89276249
178activation of Rac GTPase activity (GO:0032863)1.89222603
179regulation of type I interferon-mediated signaling pathway (GO:0060338)1.88605600

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65750673
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.64589368
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.41333666
4VDR_21846776_ChIP-Seq_THP-1_Human2.28808690
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.24274097
6DROSHA_22980978_ChIP-Seq_HELA_Human2.18000641
7EZH2_22144423_ChIP-Seq_EOC_Human2.14734607
8KDM2B_26808549_Chip-Seq_K562_Human2.10649096
9WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.05405020
10KDM2B_26808549_Chip-Seq_DND41_Human2.01377451
11TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.94446008
12ZFP281_18757296_ChIP-ChIP_E14_Mouse1.88326643
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83334240
14DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.78654302
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.72675946
16ZFP281_27345836_Chip-Seq_ESCs_Mouse1.68845746
17LXR_22292898_ChIP-Seq_THP-1_Human1.68443276
18IRF8_22096565_ChIP-ChIP_GC-B_Human1.66532103
19VDR_24763502_ChIP-Seq_THP-1_Human1.65398559
20EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.63708841
21RARB_27405468_Chip-Seq_BRAIN_Mouse1.63473212
22KDM2B_26808549_Chip-Seq_JURKAT_Human1.63115053
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.63047213
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.63047213
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61271025
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61123341
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.61028790
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60721650
29TCF7_22412390_ChIP-Seq_EML_Mouse1.60076556
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59587965
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.57256505
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.54298004
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52992563
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52480519
35ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52328330
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50703066
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50597557
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50462683
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50359850
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49445236
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49046156
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48958551
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.47437653
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46665844
45P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45718559
46SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44871672
47WT1_25993318_ChIP-Seq_PODOCYTE_Human1.44298619
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.44201854
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43261488
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41636687
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.39790766
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38805611
53MAF_26560356_Chip-Seq_TH1_Human1.38802649
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.38183216
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37384610
56CLOCK_20551151_ChIP-Seq_293T_Human1.36088301
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36058731
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35592006
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35337226
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.32576474
61MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32315055
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31883218
63RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30924189
64P68_20966046_ChIP-Seq_HELA_Human1.30907582
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.30479524
66GATA1_19941826_ChIP-Seq_K562_Human1.29339564
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29203178
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29052178
69JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29000270
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27210926
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.27103315
72SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.26968908
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.26908173
74MYC_22102868_ChIP-Seq_BL_Human1.26285346
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24895368
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24362418
77NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23055814
78UTX_26944678_Chip-Seq_JUKART_Human1.22344868
79MAF_26560356_Chip-Seq_TH2_Human1.22064867
80RACK7_27058665_Chip-Seq_MCF-7_Human1.21632707
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.21394593
82PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21307716
83STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.20504365
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.20214340
85CREB1_26743006_Chip-Seq_LNCaP_Human1.19976481
86BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18683762
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18588724
88AHR_22903824_ChIP-Seq_MCF-7_Human1.17936194
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.17344728
90RXR_22158963_ChIP-Seq_LIVER_Mouse1.17026910
91BP1_19119308_ChIP-ChIP_Hs578T_Human1.16652507
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15496129
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14949123
94TBX20_22328084_ChIP-Seq_HEART_Mouse1.14631194
95TBX20_22080862_ChIP-Seq_HEART_Mouse1.14631194
96IRF8_27001747_Chip-Seq_BMDM_Mouse1.13806259
97EP300_21415370_ChIP-Seq_HL-1_Mouse1.13692368
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12520947
99CTCF_27219007_Chip-Seq_Bcells_Human1.11575119
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11525713
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10347241
102EZH2_27304074_Chip-Seq_ESCs_Mouse1.10085361
103RUNX1_27514584_Chip-Seq_MCF-7_Human1.08414932
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08353914
105SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08007971
106NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07441110
107FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07030260
108FOXA2_19822575_ChIP-Seq_HepG2_Human1.05051396
109UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05005464
110TP53_22127205_ChIP-Seq_IMR90_Human1.04986962
111BCOR_27268052_Chip-Seq_Bcells_Human1.04661376
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04109649
113P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03969478
114SCL_19346495_ChIP-Seq_HPC-7_Human1.03328545
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03250806
116TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.03241249
117PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02703802
118TP63_22573176_ChIP-Seq_HFKS_Human1.02363924
119RING1B_27294783_Chip-Seq_ESCs_Mouse1.02340490
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.02083209
121ESR1_21235772_ChIP-Seq_MCF-7_Human1.00945773
122AR_19668381_ChIP-Seq_PC3_Human1.00489116
123TET1_21451524_ChIP-Seq_MESCs_Mouse0.99006894
124SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98994316
125ZNF263_19887448_ChIP-Seq_K562_Human0.98945112
126FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98919124
127EED_16625203_ChIP-ChIP_MESCs_Mouse0.97893974
128PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97879069
129OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97743307
130FOXO3_23340844_ChIP-Seq_DLD1_Human0.97736859
131CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97428788
132ELF1_20517297_ChIP-Seq_JURKAT_Human0.96874918
133MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96697682
134CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96592041
135RING1B_27294783_Chip-Seq_NPCs_Mouse0.96235165
136SPI1_23127762_ChIP-Seq_K562_Human0.96017833
137STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95683775
138TP53_23651856_ChIP-Seq_MEFs_Mouse0.95102262
139CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94008879
140TP53_16413492_ChIP-PET_HCT116_Human0.93799433
141CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93792244
142FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93667162
143KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93319499
144SMC4_20622854_ChIP-Seq_HELA_Human0.93033686
145ESR1_20079471_ChIP-ChIP_T-47D_Human0.92043495
146REST_21632747_ChIP-Seq_MESCs_Mouse0.90087834

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.81190637
2MP0000569_abnormal_digit_pigmentation3.74542644
3MP0004859_abnormal_synaptic_plasticity3.73466682
4MP0008438_abnormal_cutaneous_collagen2.90345643
5MP0003436_decreased_susceptibility_to2.72092134
6MP0009780_abnormal_chondrocyte_physiolo2.71378105
7MP0008961_abnormal_basal_metabolism2.70904921
8MP0005409_darkened_coat_color2.69506204
9MP0003283_abnormal_digestive_organ2.60425910
10MP0005623_abnormal_meninges_morphology2.53911986
11MP0005076_abnormal_cell_differentiation2.46703032
12MP0004858_abnormal_nervous_system2.39392075
13MP0009840_abnormal_foam_cell2.34836329
14MP0005451_abnormal_body_composition2.25338128
15MP0003300_gastrointestinal_ulcer2.20193281
16MP0003045_fibrosis2.14296140
17MP0008260_abnormal_autophagy2.08200768
18MP0003191_abnormal_cellular_cholesterol2.06268600
19MP0000751_myopathy1.97739325
20MP0002909_abnormal_adrenal_gland1.88015583
21MP0003091_abnormal_cell_migration1.82495874
22MP0004947_skin_inflammation1.82386537
23MP0001958_emphysema1.81315395
24MP0000733_abnormal_muscle_development1.75849754
25MP0003566_abnormal_cell_adhesion1.74828577
26MP0003724_increased_susceptibility_to1.73194979
27MP0005275_abnormal_skin_tensile1.72824910
28MP0010234_abnormal_vibrissa_follicle1.71677750
29MP0003453_abnormal_keratinocyte_physiol1.69519596
30MP0004272_abnormal_basement_membrane1.68336430
31MP0004381_abnormal_hair_follicle1.61798046
32MP0003172_abnormal_lysosome_physiology1.59426195
33MP0003279_aneurysm1.59278519
34MP0004510_myositis1.59080126
35MP0003635_abnormal_synaptic_transmissio1.56401984
36MP0001299_abnormal_eye_distance/1.51538617
37MP0003183_abnormal_peptide_metabolism1.51412730
38MP0002419_abnormal_innate_immunity1.49101617
39MP0000003_abnormal_adipose_tissue1.48436942
40MP0003303_peritoneal_inflammation1.48394650
41MP0001533_abnormal_skeleton_physiology1.46572310
42MP0003122_maternal_imprinting1.46201868
43MP0000685_abnormal_immune_system1.45949047
44MP0000013_abnormal_adipose_tissue1.44128679
45MP0009278_abnormal_bone_marrow1.43471186
46MP0001849_ear_inflammation1.43260463
47MP0000534_abnormal_ureter_morphology1.42122318
48MP0002234_abnormal_pharynx_morphology1.41708263
49MP0004233_abnormal_muscle_weight1.41455503
50MP0002877_abnormal_melanocyte_morpholog1.40124376
51MP0003115_abnormal_respiratory_system1.37423538
52MP0003690_abnormal_glial_cell1.35519548
53MP0005025_abnormal_response_to1.34874385
54MP0000678_abnormal_parathyroid_gland1.34047266
55MP0001790_abnormal_immune_system1.30966934
56MP0005387_immune_system_phenotype1.30966934
57MP0010352_gastrointestinal_tract_polyps1.29809975
58MP0004130_abnormal_muscle_cell1.28790374
59MP0002896_abnormal_bone_mineralization1.27492729
60MP0002089_abnormal_postnatal_growth/wei1.26369315
61MP0005503_abnormal_tendon_morphology1.26224679
62MP0005360_urolithiasis1.23999256
63MP0004087_abnormal_muscle_fiber1.23113105
64MP0002933_joint_inflammation1.22540943
65MP0004270_analgesia1.22192347
66MP0003329_amyloid_beta_deposits1.20163946
67MP0004084_abnormal_cardiac_muscle1.16994862
68MP0005375_adipose_tissue_phenotype1.15756262
69MP0003828_pulmonary_edema1.15560289
70MP0005257_abnormal_intraocular_pressure1.14424755
71MP0005000_abnormal_immune_tolerance1.13671767
72MP0010155_abnormal_intestine_physiology1.08971558
73MP0001835_abnormal_antigen_presentation1.08658320
74MP0002653_abnormal_ependyma_morphology1.08381939
75MP0002063_abnormal_learning/memory/cond1.08239632
76MP0008004_abnormal_stomach_pH1.08203204
77MP0003385_abnormal_body_wall1.07350245
78MP0000428_abnormal_craniofacial_morphol1.07048327
79MP0000537_abnormal_urethra_morphology1.04837316
80MP0004811_abnormal_neuron_physiology1.03737732
81MP0001800_abnormal_humoral_immune1.03056296
82MP0004185_abnormal_adipocyte_glucose1.02791161
83MP0003763_abnormal_thymus_physiology1.02557022
84MP0002168_other_aberrant_phenotype1.01918884
85MP0000858_altered_metastatic_potential1.01513563
86MP0005187_abnormal_penis_morphology1.01328777
87MP0010630_abnormal_cardiac_muscle1.00640386
88MP0005670_abnormal_white_adipose0.98478238
89MP0002249_abnormal_larynx_morphology0.95554346
90MP0009384_cardiac_valve_regurgitation0.95502219
91MP0002796_impaired_skin_barrier0.95473073
92MP0006082_CNS_inflammation0.94666758
93MP0002723_abnormal_immune_serum0.94661217
94MP0004264_abnormal_extraembryonic_tissu0.93667095
95MP0003942_abnormal_urinary_system0.93181037
96MP0009785_altered_susceptibility_to0.91245270
97MP0008569_lethality_at_weaning0.90374149
98MP0002452_abnormal_antigen_presenting0.90032398
99MP0005167_abnormal_blood-brain_barrier0.89899282
100MP0001348_abnormal_lacrimal_gland0.88257039
101MP0002108_abnormal_muscle_morphology0.87523909
102MP0002420_abnormal_adaptive_immunity0.87101718
103MP0001819_abnormal_immune_cell0.86987092
104MP0005390_skeleton_phenotype0.86666237
105MP0004885_abnormal_endolymph0.86630855
106MP0002925_abnormal_cardiovascular_devel0.85910484
107MP0005023_abnormal_wound_healing0.85363217
108MP0000767_abnormal_smooth_muscle0.85042572
109MP0002405_respiratory_system_inflammati0.84615429
110MP0000778_abnormal_nervous_system0.84533852
111MP0000759_abnormal_skeletal_muscle0.84504067
112MP0005464_abnormal_platelet_physiology0.84006336
113MP0005397_hematopoietic_system_phenotyp0.83479433
114MP0001545_abnormal_hematopoietic_system0.83479433
115MP0000249_abnormal_blood_vessel0.82520300
116MP0005166_decreased_susceptibility_to0.82298771
117MP0005666_abnormal_adipose_tissue0.82134505
118MP0002060_abnormal_skin_morphology0.81559593
119MP0003879_abnormal_hair_cell0.80507664
120MP0001851_eye_inflammation0.80222941
121MP0003935_abnormal_craniofacial_develop0.78978370
122MP0004145_abnormal_muscle_electrophysio0.77191529
123MP0001873_stomach_inflammation0.76898361
124MP0005248_abnormal_Harderian_gland0.76812583
125MP0003075_altered_response_to0.76525269
126MP0005164_abnormal_response_to0.76251700
127MP0000955_abnormal_spinal_cord0.75798956
128MP0000604_amyloidosis0.75693712
129MP0002064_seizures0.75361873
130MP0010368_abnormal_lymphatic_system0.75102119
131MP0005508_abnormal_skeleton_morphology0.73904058
132MP0002971_abnormal_brown_adipose0.73252397
133MP0002928_abnormal_bile_duct0.72991920
134MP0000747_muscle_weakness0.72963143
135MP0005058_abnormal_lysosome_morphology0.72699969
136MP0000920_abnormal_myelination0.71964727
137MP0003795_abnormal_bone_structure0.71552269
138MP0002269_muscular_atrophy0.70078585
139MP0003634_abnormal_glial_cell0.69292185
140MP0004883_abnormal_blood_vessel0.69136276
141MP0001845_abnormal_inflammatory_respons0.68585617
142MP0006138_congestive_heart_failure0.68477400
143MP0000266_abnormal_heart_morphology0.66742514
144MP0002837_dystrophic_cardiac_calcinosis0.66352619
145MP0003119_abnormal_digestive_system0.66174269
146MP0002090_abnormal_vision0.65807128
147MP0004036_abnormal_muscle_relaxation0.65678237
148MP0009046_muscle_twitch0.65644330
149MP0002998_abnormal_bone_remodeling0.64568516
150MP0002128_abnormal_blood_circulation0.63958368
151MP0002184_abnormal_innervation0.63204050
152MP0002152_abnormal_brain_morphology0.62894799
153MP0008770_decreased_survivor_rate0.62775998
154MP0000750_abnormal_muscle_regeneration0.60919579

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.93239292
2Obstructive sleep apnea (HP:0002870)3.74912464
3Shallow orbits (HP:0000586)3.64955105
4Protrusio acetabuli (HP:0003179)3.20820099
5Hyperacusis (HP:0010780)3.13665814
6Upper limb amyotrophy (HP:0009129)3.10784477
7Distal upper limb amyotrophy (HP:0007149)3.10784477
8Broad face (HP:0000283)3.06697941
9Broad metatarsal (HP:0001783)2.99533889
10Eczematoid dermatitis (HP:0000976)2.99313432
11Hand muscle atrophy (HP:0009130)2.82883326
12Macroorchidism (HP:0000053)2.81661849
13Dysostosis multiplex (HP:0000943)2.75009714
14Bladder diverticulum (HP:0000015)2.69143112
15Aortic aneurysm (HP:0004942)2.65084742
16Premature rupture of membranes (HP:0001788)2.63132564
17Mitral valve prolapse (HP:0001634)2.55312961
18Urinary glycosaminoglycan excretion (HP:0003541)2.54986340
19Mucopolysacchariduria (HP:0008155)2.54986340
20Abnormality of mucopolysaccharide metabolism (HP:0011020)2.54607181
21Abnormality of polysaccharide metabolism (HP:0011012)2.54607181
22Abnormality of glycosaminoglycan metabolism (HP:0004371)2.54607181
23Aneurysm (HP:0002617)2.50446241
24Dilatation of the ascending aorta (HP:0005111)2.46137732
25Elfin facies (HP:0004428)2.45153907
26Neurofibrillary tangles (HP:0002185)2.40892146
27Hemorrhage of the eye (HP:0011885)2.40695847
28Bowel diverticulosis (HP:0005222)2.39757478
29Turricephaly (HP:0000262)2.37378729
30Insomnia (HP:0100785)2.36426359
31Increased IgE level (HP:0003212)2.36064373
32Ankle contracture (HP:0006466)2.33740109
33Deep venous thrombosis (HP:0002625)2.31595867
34Abnormality of the fingertips (HP:0001211)2.30477386
35Renovascular hypertension (HP:0100817)2.29510391
36Systemic lupus erythematosus (HP:0002725)2.26764855
37Lymphangioma (HP:0100764)2.25891629
38Abnormality of the lower motor neuron (HP:0002366)2.25847981
39Long toe (HP:0010511)2.21495404
40Flat acetabular roof (HP:0003180)2.20584405
41Neoplasm of the heart (HP:0100544)2.20256396
42Genu recurvatum (HP:0002816)2.18988433
43Aortic dissection (HP:0002647)2.18624035
44Renal duplication (HP:0000075)2.16651696
45Short 4th metacarpal (HP:0010044)2.16468588
46Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.16468588
47Abnormality of liposaccharide metabolism (HP:0010968)2.14636590
48Abnormality of glycosphingolipid metabolism (HP:0004343)2.14636590
49Abnormality of glycolipid metabolism (HP:0010969)2.14636590
50Pointed chin (HP:0000307)2.13455439
51Enlarged penis (HP:0000040)2.12107895
52Gingivitis (HP:0000230)2.12013624
53Abnormality of macrophages (HP:0004311)2.09777480
54Supranuclear gaze palsy (HP:0000605)2.09626374
55Atrophic scars (HP:0001075)2.07339057
56Difficulty running (HP:0009046)2.06659188
57Thin bony cortex (HP:0002753)2.05487626
58Increased variability in muscle fiber diameter (HP:0003557)2.04158237
59Interstitial pulmonary disease (HP:0006530)2.03945547
60J-shaped sella turcica (HP:0002680)2.03731541
61Genetic anticipation (HP:0003743)2.03045998
62Hemiplegia (HP:0002301)2.02197706
63Narrow palate (HP:0000189)2.01933718
64Colitis (HP:0002583)2.00893457
65Spontaneous hematomas (HP:0007420)1.98708438
66Vertebral compression fractures (HP:0002953)1.97985104
67Lower limb amyotrophy (HP:0007210)1.97901434
68Abnormality of the thoracic spine (HP:0100711)1.96955708
69Deviation of the hallux (HP:0010051)1.95750364
70Emphysema (HP:0002097)1.95421994
71Striae distensae (HP:0001065)1.95323446
72Mildly elevated creatine phosphokinase (HP:0008180)1.93135456
73Hallux valgus (HP:0001822)1.92376901
74Hypoventilation (HP:0002791)1.90864644
75Overriding aorta (HP:0002623)1.90787036
76Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.90730333
77Mitral stenosis (HP:0001718)1.90407018
78Buphthalmos (HP:0000557)1.88734019
79Action tremor (HP:0002345)1.87509327
80Joint stiffness (HP:0001387)1.87209708
81Dysmetric saccades (HP:0000641)1.87141698
82Flat cornea (HP:0007720)1.85798886
83Thoracic kyphosis (HP:0002942)1.83509810
84Gastrointestinal infarctions (HP:0005244)1.83382956
85Abnormality of the 4th metacarpal (HP:0010012)1.83233245
86Cellulitis (HP:0100658)1.83002546
87Hyporeflexia of lower limbs (HP:0002600)1.82385772
88Abnormality of complement system (HP:0005339)1.82180801
89Nuclear cataract (HP:0100018)1.81659096
90Myositis (HP:0100614)1.81357289
91Scapular winging (HP:0003691)1.81287927
92Asymmetric septal hypertrophy (HP:0001670)1.80824422
93Vascular tortuosity (HP:0004948)1.79974835
94Glomerulonephritis (HP:0000099)1.79349269
95Heterotopia (HP:0002282)1.78006884
96Loss of speech (HP:0002371)1.77976502
97Arterial tortuosity (HP:0005116)1.77972297
98Difficulty climbing stairs (HP:0003551)1.77585630
99Increased connective tissue (HP:0009025)1.77289263
100Stridor (HP:0010307)1.76901380
101Spondylolisthesis (HP:0003302)1.75209469
102Orchitis (HP:0100796)1.74819093
103Subacute progressive viral hepatitis (HP:0006572)1.74097305
104Metaphyseal cupping (HP:0003021)1.73964676
105Onion bulb formation (HP:0003383)1.73506381
106Biconcave vertebral bodies (HP:0004586)1.72814682
107Complement deficiency (HP:0004431)1.72507432
108Recurrent gram-negative bacterial infections (HP:0005420)1.71841190
109Disproportionate tall stature (HP:0001519)1.70757137
110Type 1 muscle fiber predominance (HP:0003803)1.70691764
111Increased cerebral lipofuscin (HP:0011813)1.70239481
112Segmental peripheral demyelination/remyelination (HP:0003481)1.69729797
113Fragile skin (HP:0001030)1.69362633
114Frequent falls (HP:0002359)1.69082946
115Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.68636754
116Focal seizures (HP:0007359)1.68541621
117Bronchomalacia (HP:0002780)1.67888570
118Cervical subluxation (HP:0003308)1.66936716
119Wormian bones (HP:0002645)1.66324267
120Abnormality of skeletal muscle fiber size (HP:0012084)1.66202664
121Recurrent bacterial skin infections (HP:0005406)1.65777781
122Distal lower limb amyotrophy (HP:0008944)1.64908267
123Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.64631643
124Aortic regurgitation (HP:0001659)1.64554273
125Hypercortisolism (HP:0001578)1.64108749
126Malnutrition (HP:0004395)1.64029701
127Ulnar bowing (HP:0003031)1.63732307
128Gastrointestinal inflammation (HP:0004386)1.62026827
129Peritonitis (HP:0002586)1.61721051
130Amyloidosis (HP:0011034)1.60910935
131Congenital glaucoma (HP:0001087)1.60434646
132Deformed sella turcica (HP:0002681)1.60150927
133Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.60044221
134Recurrent abscess formation (HP:0002722)1.59315566
135Absent frontal sinuses (HP:0002688)1.58528756
136Bundle branch block (HP:0011710)1.58303365
137Arnold-Chiari malformation (HP:0002308)1.57330227
138Ankle clonus (HP:0011448)1.57267201
139Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.57237077
140Distal lower limb muscle weakness (HP:0009053)1.57050891
141Spinal rigidity (HP:0003306)1.56741643
142Visceral angiomatosis (HP:0100761)1.56702962
143Polycythemia (HP:0001901)1.56225294
144Neuronal loss in central nervous system (HP:0002529)1.56079156
145Broad thumb (HP:0011304)1.55583660
146Radial bowing (HP:0002986)1.55562003
147Cerebral inclusion bodies (HP:0100314)1.54888431
148Exostoses (HP:0100777)1.54686713
149Overgrowth (HP:0001548)1.54129529
150Vertebral arch anomaly (HP:0008438)1.53158491
151Increased density of long bones (HP:0006392)1.53064493
152Joint laxity (HP:0001388)1.52059766
153Hypoplastic ischia (HP:0003175)1.51917914
154Broad ribs (HP:0000885)1.51387619
155Urethral obstruction (HP:0000796)1.50971475
156Ankyloglossia (HP:0010296)1.50548619
157Mitral regurgitation (HP:0001653)1.50344862
158Hyperextensible skin (HP:0000974)1.50093357
159Abnormality of oral frenula (HP:0000190)1.49817041
160Achilles tendon contracture (HP:0001771)1.49767489
161Obsessive-compulsive behavior (HP:0000722)1.49166236
162Depression (HP:0000716)1.47412887
163Blue sclerae (HP:0000592)1.46152228
164Wrist flexion contracture (HP:0001239)1.43923334

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.22510104
2PRPF4B2.74558868
3RIPK12.58883696
4PKN22.56851588
5PDGFRA2.32864269
6TTN2.28581380
7PRKD32.28269753
8CAMK1G2.20455444
9SIK12.10063920
10MAP3K102.06376346
11CDK122.05851210
12ERN12.04698391
13ICK2.00359014
14MAP3K91.99366780
15SIK21.90669252
16PTK61.89797535
17CAMK1D1.83377497
18TYRO31.77857975
19MAP2K31.77596224
20EEF2K1.76864670
21DDR21.76858110
22SMG11.67187329
23PAK61.64726717
24MAP4K11.61951894
25DAPK21.60920675
26NTRK31.59624142
27MAP3K131.59378455
28TNK21.51364267
29TYK21.47814664
30DMPK1.43499933
31CAMKK11.42031429
32MAP3K31.36233837
33ZAP701.31734024
34PTK21.30765958
35PRKCH1.29287306
36RET1.28914078
37KSR21.27150574
38TAOK11.23015796
39LATS11.21278361
40BMX1.21042939
41MTOR1.19232582
42BLK1.17830501
43STK381.16634302
44MAP3K61.15206568
45PDGFRB1.14703436
46MARK11.14048439
47FGFR41.08533566
48CDC42BPA1.07630172
49MAP3K41.06415858
50IRAK31.06225400
51NTRK11.06080736
52MAP3K141.04898725
53FGFR21.03383658
54TBK11.02060115
55MARK21.01523051
56MAP3K21.01193351
57MAP3K71.01179543
58NTRK21.00808656
59LATS20.98802994
60ALK0.97585792
61PAK30.96679391
62CSK0.96109221
63JAK10.94522082
64EPHB20.93724185
65EPHB10.93133371
66PAK20.90392370
67MAP3K110.90024645
68KSR10.89814900
69JAK30.87346174
70FER0.87135425
71PTK2B0.85483021
72MAPK120.85008298
73WNK10.84613546
74SGK30.84040335
75LMTK20.83907387
76FGFR30.83338352
77MINK10.82603119
78MAPK70.81621137
79IRAK40.78524705
80SCYL20.77635586
81RPS6KC10.77047408
82RPS6KL10.77047408
83MST1R0.76942585
84EPHA20.76873749
85FGFR10.75689661
86GRK60.73107286
87BRD40.71798349
88RPS6KA20.71571733
89BTK0.67114798
90PHKG20.66825678
91PHKG10.66825678
92STK110.65870757
93PRKD10.65601686
94PRKD20.65154771
95MAP2K60.64233332
96CDK50.64229897
97ERBB20.63143380
98FGR0.62940153
99DYRK1B0.61986614
100PAK40.61492957
101MARK30.61292879
102IKBKE0.60134567
103TAOK20.60085142
104RPS6KA60.59601698
105EPHA40.59404892
106SIK30.57775767
107ROCK10.55277034
108TGFBR20.55271546
109MAPK150.55009638
110MAP3K10.54121510
111IRAK20.52869921
112HIPK20.52029918
113SGK2230.52012697
114SGK4940.52012697
115CHUK0.50786501
116MAP2K40.50775468
117LRRK20.50711701
118RIPK40.49747909
119CAMK40.49281654
120TRPM70.49205381
121SGK20.48831232
122CSF1R0.48383812
123FYN0.47678884
124HCK0.47501637
125PDPK10.47339320
126PRKG20.46007823
127PRKAA20.45758001
128CDK60.45654389
129SRC0.45259741
130PRKAA10.43726283
131SGK10.43496963
132MAPK110.43362436
133PDK10.41097480
134UHMK10.39526197
135JAK20.38091849
136MAPK80.37650410
137RPS6KA30.37500354
138INSRR0.37074702
139CAMK10.36264853
140EPHA30.36120771
141PRKCZ0.35382258
142EGFR0.33685869
143FES0.31366163
144MAPK100.30859354

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.50736174
2Glycosaminoglycan degradation_Homo sapiens_hsa005311.72261105
3Type II diabetes mellitus_Homo sapiens_hsa049301.65000779
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60788038
5Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45075937
6Nitrogen metabolism_Homo sapiens_hsa009101.38361816
7Glioma_Homo sapiens_hsa052141.38203837
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37639467
9mTOR signaling pathway_Homo sapiens_hsa041501.33490271
10Insulin secretion_Homo sapiens_hsa049111.33048212
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32763573
12Focal adhesion_Homo sapiens_hsa045101.30740526
13Dilated cardiomyopathy_Homo sapiens_hsa054141.30255816
14Chronic myeloid leukemia_Homo sapiens_hsa052201.28725591
15Dorso-ventral axis formation_Homo sapiens_hsa043201.28354147
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26689898
17Estrogen signaling pathway_Homo sapiens_hsa049151.26582637
18Staphylococcus aureus infection_Homo sapiens_hsa051501.24481110
19Proteoglycans in cancer_Homo sapiens_hsa052051.21823033
20Circadian entrainment_Homo sapiens_hsa047131.21527407
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21440954
22Leishmaniasis_Homo sapiens_hsa051401.20949901
23Gastric acid secretion_Homo sapiens_hsa049711.20024419
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19753623
25Long-term potentiation_Homo sapiens_hsa047201.19328055
26Neurotrophin signaling pathway_Homo sapiens_hsa047221.18629722
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16797189
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15583264
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15395355
30Synaptic vesicle cycle_Homo sapiens_hsa047211.15374060
31Olfactory transduction_Homo sapiens_hsa047401.15320599
32ECM-receptor interaction_Homo sapiens_hsa045121.14767724
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14509036
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13141900
35TNF signaling pathway_Homo sapiens_hsa046681.12838546
36Lysine degradation_Homo sapiens_hsa003101.12394615
37GnRH signaling pathway_Homo sapiens_hsa049121.10973197
38Endometrial cancer_Homo sapiens_hsa052131.08774917
39Insulin resistance_Homo sapiens_hsa049311.08139177
40Amoebiasis_Homo sapiens_hsa051461.07592703
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07579021
42Salivary secretion_Homo sapiens_hsa049701.07466430
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07079717
44Oxytocin signaling pathway_Homo sapiens_hsa049211.06994654
45Cholinergic synapse_Homo sapiens_hsa047251.06547429
46Prion diseases_Homo sapiens_hsa050201.05167190
47VEGF signaling pathway_Homo sapiens_hsa043701.04243847
48Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04127539
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04080837
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03785690
51Renin secretion_Homo sapiens_hsa049241.03773693
52Hepatitis C_Homo sapiens_hsa051601.03424923
53Lysosome_Homo sapiens_hsa041421.03313272
54Axon guidance_Homo sapiens_hsa043601.03294344
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02370185
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02235085
57Malaria_Homo sapiens_hsa051441.01890353
58Adherens junction_Homo sapiens_hsa045201.01231931
59ErbB signaling pathway_Homo sapiens_hsa040120.99273594
60Tuberculosis_Homo sapiens_hsa051520.98863955
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98762595
62Dopaminergic synapse_Homo sapiens_hsa047280.97249753
63Gap junction_Homo sapiens_hsa045400.96697832
64Glutamatergic synapse_Homo sapiens_hsa047240.96440424
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96379503
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.96297514
67Cocaine addiction_Homo sapiens_hsa050300.95236933
68GABAergic synapse_Homo sapiens_hsa047270.95153392
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.93563134
70T cell receptor signaling pathway_Homo sapiens_hsa046600.93247637
71Amphetamine addiction_Homo sapiens_hsa050310.92415208
72Melanogenesis_Homo sapiens_hsa049160.92189491
73Insulin signaling pathway_Homo sapiens_hsa049100.91794226
74Non-small cell lung cancer_Homo sapiens_hsa052230.91782869
75Complement and coagulation cascades_Homo sapiens_hsa046100.91782030
76Renal cell carcinoma_Homo sapiens_hsa052110.91485568
77Notch signaling pathway_Homo sapiens_hsa043300.89840074
78Morphine addiction_Homo sapiens_hsa050320.89703301
79Influenza A_Homo sapiens_hsa051640.88784620
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.88473787
81cAMP signaling pathway_Homo sapiens_hsa040240.88089516
82Inositol phosphate metabolism_Homo sapiens_hsa005620.86901910
83Pertussis_Homo sapiens_hsa051330.85550221
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85287248
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.84903502
86Chemokine signaling pathway_Homo sapiens_hsa040620.83934305
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.83144410
88Glucagon signaling pathway_Homo sapiens_hsa049220.83073379
89Rap1 signaling pathway_Homo sapiens_hsa040150.82609350
90Hepatitis B_Homo sapiens_hsa051610.82530509
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81701144
92Pancreatic cancer_Homo sapiens_hsa052120.80836036
93Bladder cancer_Homo sapiens_hsa052190.80016180
94Small cell lung cancer_Homo sapiens_hsa052220.79945241
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76226669
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75685371
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.75684018
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75199572
99Thyroid hormone synthesis_Homo sapiens_hsa049180.74803110
100Prostate cancer_Homo sapiens_hsa052150.74590887
101Bile secretion_Homo sapiens_hsa049760.74564811
102MAPK signaling pathway_Homo sapiens_hsa040100.74036512
103Hippo signaling pathway_Homo sapiens_hsa043900.73863077
104AMPK signaling pathway_Homo sapiens_hsa041520.73862569
105Prolactin signaling pathway_Homo sapiens_hsa049170.73671393
106Endocytosis_Homo sapiens_hsa041440.73494842
107Colorectal cancer_Homo sapiens_hsa052100.73306481
108Basal cell carcinoma_Homo sapiens_hsa052170.72942530
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72664603
110Choline metabolism in cancer_Homo sapiens_hsa052310.72375651
111Osteoclast differentiation_Homo sapiens_hsa043800.71285570
112Protein digestion and absorption_Homo sapiens_hsa049740.70965701
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70643996
114Platelet activation_Homo sapiens_hsa046110.69989193
115FoxO signaling pathway_Homo sapiens_hsa040680.69451004
116MicroRNAs in cancer_Homo sapiens_hsa052060.69395190
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.69262917
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69056662
119Toxoplasmosis_Homo sapiens_hsa051450.68497762
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.68334626
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67968904
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67822687
123Viral myocarditis_Homo sapiens_hsa054160.67563847
124B cell receptor signaling pathway_Homo sapiens_hsa046620.66632065
125Measles_Homo sapiens_hsa051620.65936500
126Calcium signaling pathway_Homo sapiens_hsa040200.64607316
127ABC transporters_Homo sapiens_hsa020100.64083270
128Acute myeloid leukemia_Homo sapiens_hsa052210.63376404
129Apoptosis_Homo sapiens_hsa042100.62664900
130Hedgehog signaling pathway_Homo sapiens_hsa043400.61752588
131Long-term depression_Homo sapiens_hsa047300.61419371
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.59581989
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58917672
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.58898175
135HIF-1 signaling pathway_Homo sapiens_hsa040660.55640100
136Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55518176
137PPAR signaling pathway_Homo sapiens_hsa033200.54334098
138Salmonella infection_Homo sapiens_hsa051320.52370602
139African trypanosomiasis_Homo sapiens_hsa051430.52214549
140Phagosome_Homo sapiens_hsa041450.51417650

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