ZUFSP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.87790897
2positive regulation of interferon-alpha production (GO:0032727)5.22303404
3cellular response to type I interferon (GO:0071357)4.96476390
4type I interferon signaling pathway (GO:0060337)4.96476390
5response to type I interferon (GO:0034340)4.90801479
6regulation of interferon-alpha production (GO:0032647)4.90252174
7neutrophil activation involved in immune response (GO:0002283)4.76905437
8response to peptidoglycan (GO:0032494)4.72538480
9regulation of RIG-I signaling pathway (GO:0039535)4.66174438
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.40170717
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.40170717
12modulation by symbiont of host immune response (GO:0052553)4.40170717
13positive regulation by symbiont of host defense response (GO:0052509)4.40170717
14modulation by symbiont of host defense response (GO:0052031)4.40170717
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.40170717
16antigen processing and presentation of endogenous antigen (GO:0019883)4.24817319
17DNA double-strand break processing (GO:0000729)4.19152244
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.18475677
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.18475677
20cullin deneddylation (GO:0010388)4.12214088
21DNA replication checkpoint (GO:0000076)4.10718197
22immunoglobulin mediated immune response (GO:0016064)4.09855973
23replication fork processing (GO:0031297)4.05550379
24cellular response to interferon-beta (GO:0035458)4.05090401
25positive regulation of gamma-delta T cell activation (GO:0046645)4.02948615
26positive regulation of interferon-beta production (GO:0032728)3.97918520
27regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.97200342
28negative regulation of viral genome replication (GO:0045071)3.96625125
29cellular response to exogenous dsRNA (GO:0071360)3.95897665
30positive regulation of natural killer cell differentiation (GO:0032825)3.93096134
31NIK/NF-kappaB signaling (GO:0038061)3.90030587
32maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.87801779
33interferon-gamma-mediated signaling pathway (GO:0060333)3.87227584
34regulation of T-helper 1 cell differentiation (GO:0045625)3.86062348
35chromatin remodeling at centromere (GO:0031055)3.85759841
36platelet dense granule organization (GO:0060155)3.85351381
37negative regulation of DNA-dependent DNA replication (GO:2000104)3.84690173
38positive regulation of interleukin-12 production (GO:0032735)3.83587872
39CENP-A containing nucleosome assembly (GO:0034080)3.83554613
40response to interferon-alpha (GO:0035455)3.76821825
41positive regulation of antigen processing and presentation (GO:0002579)3.68236953
42regulation of interleukin-12 biosynthetic process (GO:0045075)3.67732453
43protein deneddylation (GO:0000338)3.66246910
44regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.64109193
45regulation of mitotic spindle checkpoint (GO:1903504)3.64109193
46response to muramyl dipeptide (GO:0032495)3.63506499
47regulation of dendritic cell antigen processing and presentation (GO:0002604)3.60059584
48positive regulation of defense response to virus by host (GO:0002230)3.56595543
49neutrophil activation (GO:0042119)3.55292305
50natural killer cell mediated immunity (GO:0002228)3.51432819
51natural killer cell mediated cytotoxicity (GO:0042267)3.51432819
52transcription elongation from RNA polymerase III promoter (GO:0006385)3.50063348
53termination of RNA polymerase III transcription (GO:0006386)3.50063348
54granulocyte activation (GO:0036230)3.48827121
55negative regulation of DNA recombination (GO:0045910)3.48745753
56anterograde synaptic vesicle transport (GO:0048490)3.44573608
57defense response to protozoan (GO:0042832)3.43684084
58positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.43283977
59response to interferon-beta (GO:0035456)3.42681368
60protein localization to kinetochore (GO:0034501)3.41564149
61respiratory burst (GO:0045730)3.41057083
62macrophage activation involved in immune response (GO:0002281)3.40458899
63postreplication repair (GO:0006301)3.40294474
64positive regulation of cellular amide metabolic process (GO:0034250)3.36240628
65positive regulation of type 2 immune response (GO:0002830)3.35470045
66regulation of alpha-beta T cell proliferation (GO:0046640)3.35457771
67response to host immune response (GO:0052572)3.34701782
68response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.34701782
69centriole replication (GO:0007099)3.32942463
70regulation of interferon-beta biosynthetic process (GO:0045357)3.32846280
71positive regulation of alpha-beta T cell proliferation (GO:0046641)3.31721027
72cellular response to virus (GO:0098586)3.30182219
73positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.29824855
74regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.29688742
75response to UV-C (GO:0010225)3.29407412
76lipopolysaccharide-mediated signaling pathway (GO:0031663)3.27876959
77histone H2A acetylation (GO:0043968)3.26864072
78protein K11-linked ubiquitination (GO:0070979)3.26406924
79maturation of 5.8S rRNA (GO:0000460)3.26392355
80B cell mediated immunity (GO:0019724)3.26163767
81ribonucleoprotein complex disassembly (GO:0032988)3.25954702
82myeloid dendritic cell activation (GO:0001773)3.22795057
83histone exchange (GO:0043486)3.22414732
84spindle checkpoint (GO:0031577)3.20765279
85regulation of antigen processing and presentation (GO:0002577)3.19973618
86DNA damage response, detection of DNA damage (GO:0042769)3.18393553
87regulation of defense response to virus by host (GO:0050691)3.18206766
88mitotic spindle checkpoint (GO:0071174)3.17499700
89neural tube formation (GO:0001841)3.17296617
90T cell migration (GO:0072678)3.16991685
91proteasome assembly (GO:0043248)3.16768640
92positive regulation of interleukin-17 production (GO:0032740)3.16587760
93regulation of helicase activity (GO:0051095)3.15679610
94regulation of activation of Janus kinase activity (GO:0010533)3.15104667
95positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.14368017
96regulation of interleukin-12 production (GO:0032655)3.13804478
97regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.10373267
98attachment of spindle microtubules to kinetochore (GO:0008608)3.09945720
99defense response to virus (GO:0051607)3.07769113
100resolution of meiotic recombination intermediates (GO:0000712)3.06203407
101response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.04522738
102response to host (GO:0075136)3.04522738
103response to host defenses (GO:0052200)3.04522738
104myeloid dendritic cell differentiation (GO:0043011)3.04113393
105nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03221723
106protein prenylation (GO:0018342)3.02196451
107prenylation (GO:0097354)3.02196451
108T-helper 1 type immune response (GO:0042088)3.01093885
109myeloid cell activation involved in immune response (GO:0002275)3.01059928
110regulation of interferon-beta production (GO:0032648)3.00615855
111DNA replication-independent nucleosome assembly (GO:0006336)3.00403430
112DNA replication-independent nucleosome organization (GO:0034724)3.00403430
113positive regulation of humoral immune response (GO:0002922)3.00282719
114recombinational repair (GO:0000725)2.99742108
115exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.98072022
116cellular response to interferon-gamma (GO:0071346)2.98018494
117regulation of hypersensitivity (GO:0002883)2.97456902
118double-strand break repair via homologous recombination (GO:0000724)2.96652210
119response to protozoan (GO:0001562)2.94626644
120positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.93794354
121negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.92776148
122negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.92776148
123negative regulation of mitotic sister chromatid segregation (GO:0033048)2.92776148
124negative regulation of mitotic sister chromatid separation (GO:2000816)2.92776148
125negative regulation of sister chromatid segregation (GO:0033046)2.92776148
126regulation of interleukin-17 production (GO:0032660)2.92176507
127organelle disassembly (GO:1903008)2.91462568
128negative regulation of interleukin-17 production (GO:0032700)2.91112431
129positive regulation of T-helper cell differentiation (GO:0045624)2.88820257
130positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.88526828
131regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88127853
132microglial cell activation (GO:0001774)2.87686661
133positive regulation of response to biotic stimulus (GO:0002833)2.87014761
134regulation of nuclear cell cycle DNA replication (GO:0033262)2.86944660
135female gonad development (GO:0008585)2.86886275
136somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.85699776
137isotype switching (GO:0045190)2.85699776
138somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.85699776
139inositol phosphate catabolic process (GO:0071545)2.85188790
140kinetochore organization (GO:0051383)2.85124961
141negative regulation of chromosome segregation (GO:0051985)2.83931290
142protein K6-linked ubiquitination (GO:0085020)2.83807891
143positive regulation of chemokine biosynthetic process (GO:0045080)2.82951832
144negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.82917488
145DNA catabolic process, exonucleolytic (GO:0000738)2.82734228
146regulation of interleukin-1 beta secretion (GO:0050706)2.82665351
147interferon-gamma production (GO:0032609)2.82522444
148regulation of type I interferon-mediated signaling pathway (GO:0060338)2.82321536
149regulation of B cell receptor signaling pathway (GO:0050855)2.82069730
150negative regulation of myeloid cell apoptotic process (GO:0033033)2.82064809
151anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81946648
152regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.81896183
153positive regulation of isotype switching (GO:0045830)2.81885711
154CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.81566318
155sister chromatid segregation (GO:0000819)2.81455309
156respiratory chain complex IV assembly (GO:0008535)2.80572280
157positive regulation of type I interferon production (GO:0032481)2.80458150
158mitotic spindle assembly checkpoint (GO:0007094)2.80359638
159spindle assembly checkpoint (GO:0071173)2.79463529
160DNA replication-dependent nucleosome organization (GO:0034723)2.79168336
161DNA replication-dependent nucleosome assembly (GO:0006335)2.79168336
162natural killer cell activation (GO:0030101)2.78913238
163RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.78784006
164peptidyl-histidine modification (GO:0018202)2.78073747
165protein-cofactor linkage (GO:0018065)2.78035308
166cellular response to zinc ion (GO:0071294)2.77679200
167translesion synthesis (GO:0019985)2.76982651
168positive regulation of interleukin-2 production (GO:0032743)2.76967165
169positive regulation of B cell differentiation (GO:0045579)2.76958141
170mitochondrial DNA replication (GO:0006264)2.76648975
171positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.76418288
172microtubule depolymerization (GO:0007019)2.76367228
173microtubule anchoring (GO:0034453)2.75821037
174regulation of response to interferon-gamma (GO:0060330)2.75717384
175positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.75170876
176male meiosis I (GO:0007141)2.74569737
177signal peptide processing (GO:0006465)2.73070093
178histone mRNA metabolic process (GO:0008334)2.72601628
179synapsis (GO:0007129)2.71292985
180intra-S DNA damage checkpoint (GO:0031573)2.70073061
181tachykinin receptor signaling pathway (GO:0007217)2.69382511
182protein neddylation (GO:0045116)2.68160698
183metaphase plate congression (GO:0051310)2.68157434
184regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.67695664
185regulation of mitotic metaphase/anaphase transition (GO:0030071)2.67695664
186regulation of mitotic sister chromatid separation (GO:0010965)2.67275808
187regulation of mitotic sister chromatid segregation (GO:0033047)2.67275808
188regulation of sister chromatid segregation (GO:0033045)2.67275808
1897-methylguanosine mRNA capping (GO:0006370)2.64415940
190L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.64221859
191double-strand break repair via nonhomologous end joining (GO:0006303)2.63231297
192non-recombinational repair (GO:0000726)2.63231297
193pseudouridine synthesis (GO:0001522)2.61172807
194DNA-dependent DNA replication (GO:0006261)2.60344396
195mitotic sister chromatid segregation (GO:0000070)2.59831755
196protein localization to chromosome, centromeric region (GO:0071459)2.59603833
197transcription from RNA polymerase III promoter (GO:0006383)2.59238540
198DNA ligation (GO:0006266)2.58564788
199tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.57794656
200RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.57794656

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.89374396
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.68030383
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.59023192
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.47230542
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.70495394
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.11464197
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.10049473
8* IRF8_27001747_Chip-Seq_BMDM_Mouse3.70810228
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.29591107
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.29403235
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.18698234
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.14933641
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.10825959
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01755251
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.98880428
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.94371092
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.83897450
18ZNF274_21170338_ChIP-Seq_K562_Hela2.75419493
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.70619758
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69956663
21GATA1_22025678_ChIP-Seq_K562_Human2.67378743
22E2F7_22180533_ChIP-Seq_HELA_Human2.62661139
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43054803
24FUS_26573619_Chip-Seq_HEK293_Human2.41661731
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.39358479
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.35328531
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.29944237
28EWS_26573619_Chip-Seq_HEK293_Human2.28942337
29EGR1_19374776_ChIP-ChIP_THP-1_Human2.26556990
30VDR_22108803_ChIP-Seq_LS180_Human2.25623930
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22505373
32* SPI1_23547873_ChIP-Seq_NB4_Human2.17260935
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.15264348
34* ETS1_20019798_ChIP-Seq_JURKAT_Human2.06618708
35TAF15_26573619_Chip-Seq_HEK293_Human2.05467974
36ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03281491
37MYB_26560356_Chip-Seq_TH2_Human2.00468859
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99501514
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97808194
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.95012137
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91615227
42FOXP3_21729870_ChIP-Seq_TREG_Human1.89639369
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.87461378
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.87179795
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84355093
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83920054
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83140028
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81203245
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71798203
50MYB_26560356_Chip-Seq_TH1_Human1.69287956
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68999178
52P300_19829295_ChIP-Seq_ESCs_Human1.68577650
53SCL_19346495_ChIP-Seq_HPC-7_Human1.67345173
54MYC_18940864_ChIP-ChIP_HL60_Human1.65045824
55RUNX_20019798_ChIP-Seq_JUKART_Human1.59775757
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.55505693
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53863939
58GBX2_23144817_ChIP-Seq_PC3_Human1.53048014
59DCP1A_22483619_ChIP-Seq_HELA_Human1.52978842
60PU_27001747_Chip-Seq_BMDM_Mouse1.49910885
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49010595
62GATA3_26560356_Chip-Seq_TH2_Human1.45233924
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44298279
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43886159
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41536019
66MYC_18555785_ChIP-Seq_MESCs_Mouse1.41438295
67MAF_26560356_Chip-Seq_TH1_Human1.40693353
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38495232
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37612529
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36634080
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.34868949
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32235254
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32011613
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31128565
75ELK1_19687146_ChIP-ChIP_HELA_Human1.30987223
76GABP_19822575_ChIP-Seq_HepG2_Human1.29848973
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.29135079
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26884463
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26815784
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25393660
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24637306
82ER_23166858_ChIP-Seq_MCF-7_Human1.23575291
83MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22413088
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22020681
85NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21629165
86GATA3_27048872_Chip-Seq_THYMUS_Human1.19929502
87TTF2_22483619_ChIP-Seq_HELA_Human1.19592121
88SPI1_23127762_ChIP-Seq_K562_Human1.19086102
89GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17973926
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17460339
91IRF1_19129219_ChIP-ChIP_H3396_Human1.15445161
92MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14580007
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14223640
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13890632
95VDR_24763502_ChIP-Seq_THP-1_Human1.13078687
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12932600
97CBP_20019798_ChIP-Seq_JUKART_Human1.12932600
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12520207
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12461701
100CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12451871
101VDR_24787735_ChIP-Seq_THP-1_Human1.12299919
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.10890109
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09732061
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09725184
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09422036
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08671263
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08333302
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08188236
109GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08160750
110POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07916457
111LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06645152
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06618182
113E2F4_17652178_ChIP-ChIP_JURKAT_Human1.05898907
114GATA2_21666600_ChIP-Seq_HMVEC_Human1.05852610
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05368268
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05295631
117PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04386867
118HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.03610696
119FLI1_27457419_Chip-Seq_LIVER_Mouse1.03079290
120SMAD4_21799915_ChIP-Seq_A2780_Human1.02747465
121ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02480360
122* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02013012
123TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01583610
124TP53_22573176_ChIP-Seq_HFKS_Human1.01336069
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01142745
126CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99887661
127FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99726022
128* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97474795
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96991427
130PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96669236
131E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96539558
132P53_22387025_ChIP-Seq_ESCs_Mouse0.95722846
133* CRX_20693478_ChIP-Seq_RETINA_Mouse0.95711215
134PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95690507
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95491610
136RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95340523
137SMAD3_21741376_ChIP-Seq_EPCs_Human0.95333572
138VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95290307
139OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94976888
140MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94973819
141P300_18555785_Chip-Seq_ESCs_Mouse0.94968048
142AR_21909140_ChIP-Seq_LNCAP_Human0.94554131
143THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94549668
144CMYC_18555785_Chip-Seq_ESCs_Mouse0.94374426
145SRF_21415370_ChIP-Seq_HL-1_Mouse0.94168088
146KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93479130
147GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92360481
148GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92359270
149E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.92289814
150* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89016421
151TP63_19390658_ChIP-ChIP_HaCaT_Human0.88221077
152VDR_23849224_ChIP-Seq_CD4+_Human0.87680354
153NOTCH1_21737748_ChIP-Seq_TLL_Human0.86518963
154TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83024561
155UTX_26944678_Chip-Seq_JUKART_Human0.81227339
156GABP_17652178_ChIP-ChIP_JURKAT_Human0.80498282
157RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.78384312
158NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77817749
159VDR_21846776_ChIP-Seq_THP-1_Human0.77588065
160TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75264071
161PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74928688
162MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.74669985
163PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74239362
164STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.73940394
165GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71873595
166TFEB_21752829_ChIP-Seq_HELA_Human0.71616478
167SMRT_27268052_Chip-Seq_Bcells_Human0.71347367
168IGF1R_20145208_ChIP-Seq_DFB_Human0.70078286
169FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.69613363
170E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.69245074
171NFE2_27457419_Chip-Seq_LIVER_Mouse0.68198064
172E2F1_21310950_ChIP-Seq_MCF-7_Human0.66296257
173EGR1_23403033_ChIP-Seq_LIVER_Mouse0.65886360
174GATA1_22383799_ChIP-Seq_G1ME_Mouse0.65381837
175STAT3_18555785_Chip-Seq_ESCs_Mouse0.64818899
176FOXM1_23109430_ChIP-Seq_U2OS_Human0.64703587
177SUZ12_27294783_Chip-Seq_NPCs_Mouse0.64698434
178NMYC_18555785_Chip-Seq_ESCs_Mouse0.62411622

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.50864678
2MP0002102_abnormal_ear_morphology4.47415398
3MP0009785_altered_susceptibility_to4.19120374
4MP0002148_abnormal_hypersensitivity_rea3.60873170
5MP0005000_abnormal_immune_tolerance3.34023899
6MP0000685_abnormal_immune_system3.27613793
7MP0005671_abnormal_response_to3.24875725
8MP0005387_immune_system_phenotype3.18644044
9MP0001790_abnormal_immune_system3.18644044
10MP0003436_decreased_susceptibility_to3.11875361
11MP0005025_abnormal_response_to3.09008999
12MP0001800_abnormal_humoral_immune3.01577577
13MP0002452_abnormal_antigen_presenting2.91748516
14MP0002419_abnormal_innate_immunity2.90576326
15MP0002723_abnormal_immune_serum2.79938289
16MP0006082_CNS_inflammation2.63952053
17MP0001819_abnormal_immune_cell2.55630681
18MP0002420_abnormal_adaptive_immunity2.51114378
19MP0003724_increased_susceptibility_to2.49761370
20MP0004510_myositis2.38654848
21MP0006292_abnormal_olfactory_placode2.29666673
22MP0003718_maternal_effect2.27334459
23MP0003111_abnormal_nucleus_morphology2.27234322
24MP0004147_increased_porphyrin_level2.26268253
25MP0001853_heart_inflammation2.24828326
26MP0000569_abnormal_digit_pigmentation2.07481408
27MP0002398_abnormal_bone_marrow2.01712876
28MP0002006_tumorigenesis1.99353472
29MP0002405_respiratory_system_inflammati1.98374785
30MP0000716_abnormal_immune_system1.98326153
31MP0002938_white_spotting1.98202273
32MP0010155_abnormal_intestine_physiology1.88678533
33MP0003763_abnormal_thymus_physiology1.88552641
34MP0005464_abnormal_platelet_physiology1.88479534
35MP0002396_abnormal_hematopoietic_system1.87613217
36MP0004957_abnormal_blastocyst_morpholog1.86483060
37MP0001529_abnormal_vocalization1.81696629
38MP0001845_abnormal_inflammatory_respons1.79686802
39MP0001293_anophthalmia1.78794657
40MP0004947_skin_inflammation1.78280789
41MP0009764_decreased_sensitivity_to1.77918709
42MP0002736_abnormal_nociception_after1.75869784
43MP0005310_abnormal_salivary_gland1.75009375
44MP0009333_abnormal_splenocyte_physiolog1.73637641
45MP0003786_premature_aging1.71373204
46MP0000647_abnormal_sebaceous_gland1.70178860
47MP0002638_abnormal_pupillary_reflex1.67778590
48MP0003303_peritoneal_inflammation1.67107853
49MP0006072_abnormal_retinal_apoptosis1.65966821
50MP0005058_abnormal_lysosome_morphology1.65602518
51MP0002166_altered_tumor_susceptibility1.65323384
52MP0000689_abnormal_spleen_morphology1.63292337
53MP0002429_abnormal_blood_cell1.62490693
54MP0003195_calcinosis1.59120129
55MP0005397_hematopoietic_system_phenotyp1.58886499
56MP0001545_abnormal_hematopoietic_system1.58886499
57MP0001533_abnormal_skeleton_physiology1.57144432
58MP0005253_abnormal_eye_physiology1.55016818
59MP0004782_abnormal_surfactant_physiolog1.54743560
60MP0008469_abnormal_protein_level1.53878521
61MP0003121_genomic_imprinting1.51605291
62MP0002751_abnormal_autonomic_nervous1.50235918
63MP0002722_abnormal_immune_system1.49445342
64MP0004808_abnormal_hematopoietic_stem1.44851501
65MP0008789_abnormal_olfactory_epithelium1.43431832
66MP0002277_abnormal_respiratory_mucosa1.42381155
67MP0008057_abnormal_DNA_replication1.39655140
68MP0002837_dystrophic_cardiac_calcinosis1.38405093
69MP0008995_early_reproductive_senescence1.36855213
70MP0003221_abnormal_cardiomyocyte_apopto1.34270122
71MP0006035_abnormal_mitochondrial_morpho1.34238204
72MP0003448_altered_tumor_morphology1.31706447
73MP0002163_abnormal_gland_morphology1.31656272
74MP0000858_altered_metastatic_potential1.28588439
75MP0001764_abnormal_homeostasis1.27396090
76MP0003890_abnormal_embryonic-extraembry1.27053826
77MP0008932_abnormal_embryonic_tissue1.21331970
78MP0005646_abnormal_pituitary_gland1.20671925
79MP0005499_abnormal_olfactory_system1.20073146
80MP0005394_taste/olfaction_phenotype1.20073146
81MP0001968_abnormal_touch/_nociception1.19793659
82MP0005187_abnormal_penis_morphology1.18968462
83MP0009278_abnormal_bone_marrow1.17901379
84MP0003172_abnormal_lysosome_physiology1.15234860
85MP0004270_analgesia1.14187886
86MP0000015_abnormal_ear_pigmentation1.13131018
87MP0003567_abnormal_fetal_cardiomyocyte1.13103929
88MP0003119_abnormal_digestive_system1.12948627
89MP0005408_hypopigmentation1.12425452
90MP0003937_abnormal_limbs/digits/tail_de1.11844581
91MP0009046_muscle_twitch1.11446935
92MP0000343_altered_response_to1.10560031
93MP0000490_abnormal_crypts_of1.09626644
94MP0005084_abnormal_gallbladder_morpholo1.09616358
95MP0000427_abnormal_hair_cycle1.08978034
96MP0005174_abnormal_tail_pigmentation1.08122655
97MP0002233_abnormal_nose_morphology1.07722465
98MP0003122_maternal_imprinting1.06551371
99MP0000631_abnormal_neuroendocrine_gland1.06131460
100MP0003191_abnormal_cellular_cholesterol1.05093431
101MP0002998_abnormal_bone_remodeling1.04410567
102MP0000703_abnormal_thymus_morphology1.03274191
103MP0006054_spinal_hemorrhage1.02968059
104MP0001286_abnormal_eye_development1.01140741
105MP0010307_abnormal_tumor_latency1.00299675
106MP0002822_catalepsy0.99235311
107MP0009763_increased_sensitivity_to0.98564417
108MP0004133_heterotaxia0.98237634
109MP0003283_abnormal_digestive_organ0.97814487
110MP0002210_abnormal_sex_determination0.97465425
111MP0001727_abnormal_embryo_implantation0.97331147
112MP0002234_abnormal_pharynx_morphology0.96720587
113MP0002138_abnormal_hepatobiliary_system0.95484968
114MP0003011_delayed_dark_adaptation0.95059748
115MP0008058_abnormal_DNA_repair0.94438334
116MP0001324_abnormal_eye_pigmentation0.92304469
117MP0001929_abnormal_gametogenesis0.92225827
118MP0002132_abnormal_respiratory_system0.91718006
119MP0003806_abnormal_nucleotide_metabolis0.91413306
120MP0003693_abnormal_embryo_hatching0.90413678
121MP0006276_abnormal_autonomic_nervous0.89779351
122MP0010094_abnormal_chromosome_stability0.88653180
123MP0005391_vision/eye_phenotype0.88479323
124MP0008260_abnormal_autophagy0.87382619
125MP0001873_stomach_inflammation0.86735735
126MP0002090_abnormal_vision0.85865075
127MP0003880_abnormal_central_pattern0.85782781
128MP0000653_abnormal_sex_gland0.84752521
129MP0003186_abnormal_redox_activity0.84733751
130MP0008007_abnormal_cellular_replicative0.83750449
131MP0003183_abnormal_peptide_metabolism0.83704655
132MP0003755_abnormal_palate_morphology0.83538654
133MP0005551_abnormal_eye_electrophysiolog0.83138518
134MP0005248_abnormal_Harderian_gland0.82275880
135MP0000516_abnormal_urinary_system0.80385366
136MP0005367_renal/urinary_system_phenotyp0.80385366
137MP0001697_abnormal_embryo_size0.79918944
138MP0005647_abnormal_sex_gland0.79856008
139MP0000371_diluted_coat_color0.79822978
140MP0001145_abnormal_male_reproductive0.78652585
141MP0003075_altered_response_to0.78587475
142MP0005390_skeleton_phenotype0.78386264
143MP0002177_abnormal_outer_ear0.78099914
144MP0006036_abnormal_mitochondrial_physio0.77089553
145MP0002019_abnormal_tumor_incidence0.75411699
146MP0002084_abnormal_developmental_patter0.75162293
147MP0000372_irregular_coat_pigmentation0.74865753
148MP0001486_abnormal_startle_reflex0.74057229
149MP0004215_abnormal_myocardial_fiber0.73959937
150MP0001919_abnormal_reproductive_system0.73815528
151MP0003077_abnormal_cell_cycle0.73723895
152MP0003787_abnormal_imprinting0.71300121
153MP0008877_abnormal_DNA_methylation0.70416199
154MP0003943_abnormal_hepatobiliary_system0.69249290
155MP0005645_abnormal_hypothalamus_physiol0.68670208
156MP0003698_abnormal_male_reproductive0.68494882
157MP0003866_abnormal_defecation0.68440386
158MP0003385_abnormal_body_wall0.68051917
159MP0000778_abnormal_nervous_system0.67503629
160MP0002933_joint_inflammation0.67345275
161MP0010386_abnormal_urinary_bladder0.66975670
162MP0000383_abnormal_hair_follicle0.66962088
163MP0002111_abnormal_tail_morphology0.66928212
164MP0005379_endocrine/exocrine_gland_phen0.66121686
165MP0005075_abnormal_melanosome_morpholog0.64952175
166MP0001348_abnormal_lacrimal_gland0.64086884
167MP0005166_decreased_susceptibility_to0.63237054
168MP0009697_abnormal_copulation0.61555753
169MP0009840_abnormal_foam_cell0.61487219
170MP0003091_abnormal_cell_migration0.60797985
171MP0002095_abnormal_skin_pigmentation0.57742837
172MP0009765_abnormal_xenobiotic_induced0.57737933
173MP0010352_gastrointestinal_tract_polyps0.57552080
174MP0000249_abnormal_blood_vessel0.56711898
175MP0002693_abnormal_pancreas_physiology0.56588358
176MP0000627_abnormal_mammary_gland0.53032767
177MP0001119_abnormal_female_reproductive0.52436398
178MP0002136_abnormal_kidney_physiology0.51853299
179MP0000313_abnormal_cell_death0.51112454

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.88753339
2Recurrent bacterial skin infections (HP:0005406)5.52480588
3Retrobulbar optic neuritis (HP:0100654)5.31401043
4Optic neuritis (HP:0100653)5.31401043
5Eczematoid dermatitis (HP:0000976)5.16663417
6Elevated erythrocyte sedimentation rate (HP:0003565)5.01352246
7Myositis (HP:0100614)4.98729447
8Orchitis (HP:0100796)4.90250555
9Autoimmune thrombocytopenia (HP:0001973)4.82421606
10Mediastinal lymphadenopathy (HP:0100721)4.35086599
11Increased IgM level (HP:0003496)4.21796990
12Vasculitis (HP:0002633)4.16353611
13Recurrent viral infections (HP:0004429)4.08861454
14Recurrent fungal infections (HP:0002841)3.99104154
15Recurrent gram-negative bacterial infections (HP:0005420)3.90779581
16Abnormality of macrophages (HP:0004311)3.67603024
17Recurrent skin infections (HP:0001581)3.61472527
18Chronic otitis media (HP:0000389)3.47022776
19Pulmonary infiltrates (HP:0002113)3.43186647
20Keratoconjunctivitis sicca (HP:0001097)3.28914898
21Recurrent cutaneous fungal infections (HP:0011370)3.24371366
22Chronic mucocutaneous candidiasis (HP:0002728)3.24371366
23Obstructive lung disease (HP:0006536)3.23213844
24Chronic obstructive pulmonary disease (HP:0006510)3.23213844
25Renal cortical cysts (HP:0000803)3.21043273
26Basal ganglia calcification (HP:0002135)3.20875300
27Meningitis (HP:0001287)3.19431817
28Prostate neoplasm (HP:0100787)3.15594791
29Increased hepatocellular lipid droplets (HP:0006565)3.03545600
30Keratoconjunctivitis (HP:0001096)3.02673411
31Stomatitis (HP:0010280)3.00440182
32Recurrent bronchitis (HP:0002837)2.98836060
33Abnormality of the labia minora (HP:0012880)2.98389905
34Hypergammaglobulinemia (HP:0010702)2.96086916
35Methylmalonic acidemia (HP:0002912)2.95927624
36Gingivitis (HP:0000230)2.94846587
37Acute necrotizing encephalopathy (HP:0006965)2.90699588
38Agammaglobulinemia (HP:0004432)2.90205021
39Lipid accumulation in hepatocytes (HP:0006561)2.89920184
40Leukocytosis (HP:0001974)2.88646386
41Abnormality of aspartate family amino acid metabolism (HP:0010899)2.88206185
42Colon cancer (HP:0003003)2.87314954
43Periodontitis (HP:0000704)2.85329685
44Abnormality of T cell physiology (HP:0011840)2.82218580
45Meckel diverticulum (HP:0002245)2.81075152
46Arterial thrombosis (HP:0004420)2.79413548
47Recurrent pneumonia (HP:0006532)2.77775455
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.75754433
49Severe combined immunodeficiency (HP:0004430)2.75211610
50Abnormality of the ileum (HP:0001549)2.75154109
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.74394064
52Encephalitis (HP:0002383)2.74255754
53Neoplasm of the adrenal cortex (HP:0100641)2.73942656
54Abnormality of T cell number (HP:0011839)2.73449029
55Combined immunodeficiency (HP:0005387)2.73238385
56IgG deficiency (HP:0004315)2.72852169
57Abnormality of T cells (HP:0002843)2.71483773
58Hemoptysis (HP:0002105)2.68996672
59Systemic lupus erythematosus (HP:0002725)2.66455375
60Gastrointestinal infarctions (HP:0005244)2.66377980
61Eosinophilia (HP:0001880)2.66281119
62Progressive macrocephaly (HP:0004481)2.65645948
63Abnormality of the prostate (HP:0008775)2.65101148
64Abnormality of chromosome stability (HP:0003220)2.64894542
65Increased CSF lactate (HP:0002490)2.63827890
66Pustule (HP:0200039)2.62497671
67Granulocytopenia (HP:0001913)2.60450946
68Acute encephalopathy (HP:0006846)2.58342124
69Cellulitis (HP:0100658)2.57599525
70Thyroiditis (HP:0100646)2.55137945
71Abnormality of eosinophils (HP:0001879)2.54425811
72Abnormal mitochondria in muscle tissue (HP:0008316)2.52406530
73Panhypogammaglobulinemia (HP:0003139)2.50208537
74Mitochondrial inheritance (HP:0001427)2.48695918
75Recurrent lower respiratory tract infections (HP:0002783)2.46431724
76Volvulus (HP:0002580)2.44599449
77Pancreatic cysts (HP:0001737)2.43372917
78Small intestinal stenosis (HP:0012848)2.43325929
79Duodenal stenosis (HP:0100867)2.43325929
80Abnormality of cells of the lymphoid lineage (HP:0012140)2.43137017
81Lymphopenia (HP:0001888)2.42700972
82Thrombocytosis (HP:0001894)2.42488065
83Chronic diarrhea (HP:0002028)2.40810789
84T lymphocytopenia (HP:0005403)2.40183499
85Pancreatic fibrosis (HP:0100732)2.39974603
86Molar tooth sign on MRI (HP:0002419)2.39621902
87Abnormality of midbrain morphology (HP:0002418)2.39621902
88Osteomyelitis (HP:0002754)2.38910300
89IgA deficiency (HP:0002720)2.38812318
90Intestinal atresia (HP:0011100)2.37678523
91Premature loss of primary teeth (HP:0006323)2.37670245
92Neoplasm of the adrenal gland (HP:0100631)2.35754601
93Abnormality of the preputium (HP:0100587)2.31449904
94Abnormality of methionine metabolism (HP:0010901)2.29898009
95Petechiae (HP:0000967)2.28693358
96Vacuolated lymphocytes (HP:0001922)2.27895854
97Abnormal lung lobation (HP:0002101)2.27631875
98IgM deficiency (HP:0002850)2.27063498
99Pancreatic islet-cell hyperplasia (HP:0004510)2.26242905
100Nasal polyposis (HP:0100582)2.24169998
101Abnormality of the pleura (HP:0002103)2.23256575
1023-Methylglutaconic aciduria (HP:0003535)2.22281855
103Abnormality of the duodenum (HP:0002246)2.21544792
104Acute myeloid leukemia (HP:0004808)2.19037978
105Abnormality of the renal cortex (HP:0011035)2.18227577
106Chromsome breakage (HP:0040012)2.17390499
107Autoimmune hemolytic anemia (HP:0001890)2.15370010
108Keratitis (HP:0000491)2.15200668
109Hepatoblastoma (HP:0002884)2.15095827
110Nephroblastoma (Wilms tumor) (HP:0002667)2.14438540
111Chronic sinusitis (HP:0011109)2.14424558
112Anorexia (HP:0002039)2.13399290
113Cleft eyelid (HP:0000625)2.13385802
114Methylmalonic aciduria (HP:0012120)2.13004363
115Neutropenia (HP:0001875)2.12264671
116Renal Fanconi syndrome (HP:0001994)2.11610077
117Abnormality of the fingertips (HP:0001211)2.09777424
118Embryonal renal neoplasm (HP:0011794)2.07995045
119Lymphoma (HP:0002665)2.06488805
120Pendular nystagmus (HP:0012043)2.06095174
121Joint swelling (HP:0001386)2.04964110
122Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04148286
123Gingival bleeding (HP:0000225)2.03221918
124Abnormality of serum amino acid levels (HP:0003112)2.02224694
125Thick nail (HP:0001805)2.01506817
126Gangrene (HP:0100758)2.01142819
127Tetraparesis (HP:0002273)2.01038332
128Median cleft lip (HP:0000161)2.00606959
129Hepatic necrosis (HP:0002605)1.99504278
130Gastrointestinal stroma tumor (HP:0100723)1.99248774
131Abnormality of the pericardium (HP:0001697)1.97579275
132B lymphocytopenia (HP:0010976)1.97285366
133Abnormality of B cell number (HP:0010975)1.97285366
134Sepsis (HP:0100806)1.96590493
135Porencephaly (HP:0002132)1.96501599
136Cerebral edema (HP:0002181)1.96345592
137Disinhibition (HP:0000734)1.95301718
138Increased serum lactate (HP:0002151)1.94807534
139Thyroid carcinoma (HP:0002890)1.94776400
140Sloping forehead (HP:0000340)1.94021408
141Decreased activity of mitochondrial respiratory chain (HP:0008972)1.94015714
142Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.94015714
143Brushfield spots (HP:0001088)1.92751557
144Abnormality of alanine metabolism (HP:0010916)1.92073299
145Hyperalaninemia (HP:0003348)1.92073299
146Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92073299
147Aplasia/Hypoplasia of the tibia (HP:0005772)1.91245758
148Hepatocellular necrosis (HP:0001404)1.90667560
149Short tibia (HP:0005736)1.90294676
150Albinism (HP:0001022)1.90254922
151Hypoplasia of the thymus (HP:0000778)1.89353344
152Abnormal protein glycosylation (HP:0012346)1.89339243
153Abnormal glycosylation (HP:0012345)1.89339243
154Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89339243
155Abnormal protein N-linked glycosylation (HP:0012347)1.89339243
156Urticaria (HP:0001025)1.88882528
157Arthralgia (HP:0002829)1.88794844
158Alveolar cell carcinoma (HP:0006519)1.87884744
159Absent frontal sinuses (HP:0002688)1.87627636
160Medial flaring of the eyebrow (HP:0010747)1.87455026
161Recurrent sinusitis (HP:0011108)1.87419224
162True hermaphroditism (HP:0010459)1.86830614
163Birth length less than 3rd percentile (HP:0003561)1.86697206
164Degeneration of the lateral corticospinal tracts (HP:0002314)1.85015684
165Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85015684
166Hypothermia (HP:0002045)1.83923974
167Lactic acidosis (HP:0003128)1.82398254
168Limb hypertonia (HP:0002509)1.82162163
169Bile duct proliferation (HP:0001408)1.81359083
170Abnormal biliary tract physiology (HP:0012439)1.81359083
171Type I transferrin isoform profile (HP:0003642)1.78419455
172Long clavicles (HP:0000890)1.77715473
173Decreased central vision (HP:0007663)1.74801938
174Myelodysplasia (HP:0002863)1.74646811
175Progressive inability to walk (HP:0002505)1.72509265
176Abnormality of macular pigmentation (HP:0008002)1.72370803
177Abnormality of the metopic suture (HP:0005556)1.72347929
178Triphalangeal thumb (HP:0001199)1.72091007
179Increased serum pyruvate (HP:0003542)1.71751569
180Abnormality of the anterior horn cell (HP:0006802)1.71169081
181Degeneration of anterior horn cells (HP:0002398)1.71169081
182Abnormal hair whorl (HP:0010721)1.71029972
183Hypoglycemic coma (HP:0001325)1.70910574
184Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.70232389
185Postaxial foot polydactyly (HP:0001830)1.69757788
186Drooling (HP:0002307)1.68682500
187Bifid tongue (HP:0010297)1.67796645
188Optic disc pallor (HP:0000543)1.67450646
189Neoplasm of the oral cavity (HP:0100649)1.67323422
190Abnormality of the carotid arteries (HP:0005344)1.66568292
191Metaphyseal dysplasia (HP:0100255)1.64881557
192Postaxial hand polydactyly (HP:0001162)1.64585930
193Microvesicular hepatic steatosis (HP:0001414)1.64016181

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.48786206
2TYK23.68612505
3IRAK43.41475645
4TXK3.41054411
5WNK33.32461485
6TBK13.31446808
7IKBKE3.17558241
8IRAK33.03081778
9JAK32.97279183
10IKBKB2.96838886
11MAP4K12.84398130
12TRIM282.77367155
13BLK2.68707542
14BCR2.63425353
15WEE12.62235885
16BUB12.62006281
17BMPR22.59691382
18MAP3K42.45087754
19FRK2.42301758
20RIPK42.40822192
21MKNK22.33699659
22PIM22.29088966
23KIT2.22409225
24JAK12.21212319
25MAP3K132.20615842
26TSSK62.16137690
27NEK12.12248697
28PBK2.06084848
29CHUK2.04905404
30TNIK2.03076161
31PLK31.99049195
32MAP4K21.95254156
33MAPK131.76060834
34CASK1.73747287
35TTK1.69208971
36TEC1.66070471
37RPS6KA41.65291812
38MAP2K71.64073543
39ACVR1B1.49717147
40SYK1.48959596
41PIM11.48659421
42TAOK31.44109449
43CSNK1G11.43237312
44ZAP701.42250278
45CDC71.41400828
46EIF2AK21.40472602
47PLK21.39914645
48PLK11.28131797
49CSNK1G31.27635022
50BTK1.25350972
51STK241.24352375
52MST41.21212871
53NUAK11.19686528
54DYRK31.19541825
55NEK91.18576928
56LYN1.18198463
57BRSK21.16857370
58CSNK1G21.16674336
59STK31.12314145
60CSK1.08343655
61LCK1.05592018
62CSNK1A1L1.02717727
63HCK1.02685176
64DYRK21.00272352
65YES11.00060677
66MINK10.98050981
67PDK20.96273002
68EIF2AK10.94655648
69CSF1R0.93129859
70STK40.92306700
71FGFR40.90891135
72PRPF4B0.90048390
73CLK10.89425837
74IRAK10.88466470
75SIK30.87509239
76ARAF0.85970977
77GRK10.85903623
78FGFR30.85123134
79CHEK20.83167024
80STK100.82471342
81MATK0.79018585
82ZAK0.77599176
83NLK0.76609764
84TAF10.76524245
85VRK20.75364472
86MAP3K120.73459592
87OXSR10.73137394
88PINK10.73129548
89PNCK0.72691026
90PLK40.71316985
91NME20.70533484
92STK160.69634184
93EIF2AK30.69277918
94ADRBK20.68708511
95ERBB30.67888019
96PRKCG0.67146213
97WNK40.65404628
98ATR0.62487110
99MARK30.60336851
100PAK30.59769234
101PRKCE0.58546041
102ITK0.58091630
103RPS6KA50.57833370
104MAP3K50.56502992
105RAF10.56350580
106EPHA30.55791195
107PRKCD0.55564836
108TRPM70.55378667
109AURKB0.55357026
110JAK20.54679484
111IRAK20.53674014
112STK38L0.53542675
113CHEK10.52106413
114PASK0.51414682
115CSNK1E0.49628309
116TLK10.48704636
117NEK60.47779900
118INSRR0.47021553
119CCNB10.46949244
120STK390.46287228
121PRKCQ0.46161900
122BCKDK0.45316710
123CSNK2A10.44449995
124BRAF0.43681783
125CSNK2A20.42100765
126ABL10.41706168
127MOS0.41590725
128NEK20.40109836
129NME10.38791242
130MUSK0.38340384
131GRK70.37879723
132CSNK1D0.37786772
133TGFBR20.37647120
134PRKDC0.35619996
135CDK20.33796913
136PRKG10.33704081
137FES0.33415594
138CDK10.33385716
139MARK10.33061807
140AKT30.32863575
141PKN10.31097553
142RPS6KA60.30893969
143TGFBR10.29837144
144CAMKK20.29727112
145EPHA40.29499686
146EGFR0.29374605
147SRPK10.28684309
148MKNK10.28404370
149CAMK2A0.28397459
150FGFR10.28267144
151PRKACB0.28053651
152FLT30.27221035
153TIE10.26451895
154PIK3CG0.26097751
155VRK10.25436838
156CDK90.24563164
157ABL20.22469299
158PIK3CA0.22227850
159MAPKAPK20.21143941
160BMPR1B0.20681674
161SGK20.19887717
162ERN10.19643763
163CDK40.19499484
164TESK10.19052358
165CDK60.19012446
166ATM0.18042157
167IGF1R0.18034466
168BRD40.17586876

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.47283894
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.25621725
3Allograft rejection_Homo sapiens_hsa053303.22905469
4Graft-versus-host disease_Homo sapiens_hsa053323.11957101
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.86994711
6Measles_Homo sapiens_hsa051622.82815077
7Leishmaniasis_Homo sapiens_hsa051402.81142957
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.80053605
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.66749110
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.66238796
11Legionellosis_Homo sapiens_hsa051342.50234546
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.48224826
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.41879189
14Primary immunodeficiency_Homo sapiens_hsa053402.37204738
15Oxidative phosphorylation_Homo sapiens_hsa001902.35680103
16Propanoate metabolism_Homo sapiens_hsa006402.33872544
17Herpes simplex infection_Homo sapiens_hsa051682.27053441
18Influenza A_Homo sapiens_hsa051642.22754658
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.08491981
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.06454817
21Type I diabetes mellitus_Homo sapiens_hsa049402.03808544
22Parkinsons disease_Homo sapiens_hsa050122.03606196
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.00729803
24Staphylococcus aureus infection_Homo sapiens_hsa051501.97504799
25RNA transport_Homo sapiens_hsa030131.92248833
26Osteoclast differentiation_Homo sapiens_hsa043801.88816706
27Pertussis_Homo sapiens_hsa051331.88124992
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86865890
29TNF signaling pathway_Homo sapiens_hsa046681.84568231
30Steroid biosynthesis_Homo sapiens_hsa001001.82154120
31Butanoate metabolism_Homo sapiens_hsa006501.79667890
32Autoimmune thyroid disease_Homo sapiens_hsa053201.79235763
33Rheumatoid arthritis_Homo sapiens_hsa053231.78794876
34Malaria_Homo sapiens_hsa051441.68808970
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.63539376
36B cell receptor signaling pathway_Homo sapiens_hsa046621.61956494
37Tuberculosis_Homo sapiens_hsa051521.61180179
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60522403
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60269580
40Phototransduction_Homo sapiens_hsa047441.58643055
41Hematopoietic cell lineage_Homo sapiens_hsa046401.57055433
42Antigen processing and presentation_Homo sapiens_hsa046121.56942317
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51810038
44Asthma_Homo sapiens_hsa053101.48552329
45Huntingtons disease_Homo sapiens_hsa050161.43673084
46Toxoplasmosis_Homo sapiens_hsa051451.43175820
47Selenocompound metabolism_Homo sapiens_hsa004501.37611062
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36898748
49Hepatitis B_Homo sapiens_hsa051611.35234025
50Apoptosis_Homo sapiens_hsa042101.33820385
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32334190
52Chemokine signaling pathway_Homo sapiens_hsa040621.26017284
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25987081
54Nicotine addiction_Homo sapiens_hsa050331.25758944
55Base excision repair_Homo sapiens_hsa034101.25576149
56Purine metabolism_Homo sapiens_hsa002301.21912337
57Hepatitis C_Homo sapiens_hsa051601.16001290
58Salmonella infection_Homo sapiens_hsa051321.15811070
59African trypanosomiasis_Homo sapiens_hsa051431.13885012
60Shigellosis_Homo sapiens_hsa051311.13877228
61Regulation of autophagy_Homo sapiens_hsa041401.13773737
62Oocyte meiosis_Homo sapiens_hsa041141.13016046
63Non-homologous end-joining_Homo sapiens_hsa034501.12164699
64Viral myocarditis_Homo sapiens_hsa054161.08569382
65Peroxisome_Homo sapiens_hsa041461.06838492
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06818810
67Epstein-Barr virus infection_Homo sapiens_hsa051691.06080959
68Proteasome_Homo sapiens_hsa030501.04300959
69Alzheimers disease_Homo sapiens_hsa050101.01296045
70Phagosome_Homo sapiens_hsa041450.98232641
71Homologous recombination_Homo sapiens_hsa034400.97869844
72T cell receptor signaling pathway_Homo sapiens_hsa046600.97745537
73Collecting duct acid secretion_Homo sapiens_hsa049660.97507227
74Pyruvate metabolism_Homo sapiens_hsa006200.96996832
75Fatty acid elongation_Homo sapiens_hsa000620.96808144
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.95862422
77Folate biosynthesis_Homo sapiens_hsa007900.91926566
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89858107
79mRNA surveillance pathway_Homo sapiens_hsa030150.88873772
80Vitamin B6 metabolism_Homo sapiens_hsa007500.87850663
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86595168
82Acute myeloid leukemia_Homo sapiens_hsa052210.82682674
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80635903
84Prolactin signaling pathway_Homo sapiens_hsa049170.79291589
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79283352
86Lysosome_Homo sapiens_hsa041420.78875075
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77633436
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76431862
89Caffeine metabolism_Homo sapiens_hsa002320.75337714
90Taste transduction_Homo sapiens_hsa047420.74547745
91DNA replication_Homo sapiens_hsa030300.74476810
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73773347
93Sulfur metabolism_Homo sapiens_hsa009200.73187225
94p53 signaling pathway_Homo sapiens_hsa041150.71633731
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.71110918
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69201301
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65499419
98Other glycan degradation_Homo sapiens_hsa005110.65275208
99Metabolic pathways_Homo sapiens_hsa011000.63909240
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63538805
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60460309
102Viral carcinogenesis_Homo sapiens_hsa052030.60351943
103Olfactory transduction_Homo sapiens_hsa047400.60072729
104Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59697591
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59475145
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58958693
107Small cell lung cancer_Homo sapiens_hsa052220.58750361
108Carbon metabolism_Homo sapiens_hsa012000.58003866
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57479573
110Fatty acid metabolism_Homo sapiens_hsa012120.57240891
111Nitrogen metabolism_Homo sapiens_hsa009100.57004870
112HTLV-I infection_Homo sapiens_hsa051660.56942089
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56465597
114Pancreatic cancer_Homo sapiens_hsa052120.55520244
115One carbon pool by folate_Homo sapiens_hsa006700.54408310
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53952056
117Chronic myeloid leukemia_Homo sapiens_hsa052200.53906508
118Ribosome_Homo sapiens_hsa030100.52156760
119Basal transcription factors_Homo sapiens_hsa030220.50851866
120Mismatch repair_Homo sapiens_hsa034300.49586189
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.49262586
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47903997
123Pyrimidine metabolism_Homo sapiens_hsa002400.47220980
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47071893
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.46052162
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45589433
127Platelet activation_Homo sapiens_hsa046110.42777759
128RNA degradation_Homo sapiens_hsa030180.41581121
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40493840
130RNA polymerase_Homo sapiens_hsa030200.39586894
131Fanconi anemia pathway_Homo sapiens_hsa034600.39324054
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.39249541
133Cell cycle_Homo sapiens_hsa041100.39134247
134Tryptophan metabolism_Homo sapiens_hsa003800.36734802
135Nucleotide excision repair_Homo sapiens_hsa034200.36331494
136Glutathione metabolism_Homo sapiens_hsa004800.35614983
137GABAergic synapse_Homo sapiens_hsa047270.34888511
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30922102
139HIF-1 signaling pathway_Homo sapiens_hsa040660.29379210
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29330800
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.28627555
142Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28541702
143Ether lipid metabolism_Homo sapiens_hsa005650.28227092
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25455706
145N-Glycan biosynthesis_Homo sapiens_hsa005100.25431961
146Amoebiasis_Homo sapiens_hsa051460.25162381
147TGF-beta signaling pathway_Homo sapiens_hsa043500.25073728
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22177309
149Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21519750
150Dopaminergic synapse_Homo sapiens_hsa047280.20632662
151Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.20556666
152Systemic lupus erythematosus_Homo sapiens_hsa053220.20308966
153Prostate cancer_Homo sapiens_hsa052150.19712496
154Circadian rhythm_Homo sapiens_hsa047100.19709528
155Arachidonic acid metabolism_Homo sapiens_hsa005900.18813877
156beta-Alanine metabolism_Homo sapiens_hsa004100.18324616
157Hedgehog signaling pathway_Homo sapiens_hsa043400.18313071
158Protein export_Homo sapiens_hsa030600.18144349
159Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17795758
160MicroRNAs in cancer_Homo sapiens_hsa052060.17459954
161Alcoholism_Homo sapiens_hsa050340.17327593
162Adipocytokine signaling pathway_Homo sapiens_hsa049200.17248195
163Fatty acid degradation_Homo sapiens_hsa000710.17120757
164FoxO signaling pathway_Homo sapiens_hsa040680.17093793
165Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.17039418
166Notch signaling pathway_Homo sapiens_hsa043300.16870730
167Spliceosome_Homo sapiens_hsa030400.15706870
168Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15495182
169Synaptic vesicle cycle_Homo sapiens_hsa047210.14521410

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