ZW10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)5.77536603
2* mitotic metaphase plate congression (GO:0007080)5.01401095
3DNA strand elongation involved in DNA replication (GO:0006271)4.87124991
4* protein localization to kinetochore (GO:0034501)4.84677443
5DNA unwinding involved in DNA replication (GO:0006268)4.81726512
6telomere maintenance via semi-conservative replication (GO:0032201)4.75031192
7DNA strand elongation (GO:0022616)4.74914108
8establishment of viral latency (GO:0019043)4.68233965
9DNA replication initiation (GO:0006270)4.62405328
10DNA replication checkpoint (GO:0000076)4.61893333
11meiotic chromosome segregation (GO:0045132)4.56113773
12* metaphase plate congression (GO:0051310)4.56024778
13mitotic recombination (GO:0006312)4.53609505
14telomere maintenance via recombination (GO:0000722)4.48918779
15* mitotic sister chromatid segregation (GO:0000070)4.43385601
16ribosome assembly (GO:0042255)4.42378478
17* protein localization to chromosome, centromeric region (GO:0071459)4.32142580
18IMP biosynthetic process (GO:0006188)4.14619708
19mitotic chromosome condensation (GO:0007076)4.13793849
20CENP-A containing nucleosome assembly (GO:0034080)4.11362112
21nucleobase biosynthetic process (GO:0046112)4.09973900
22* establishment of chromosome localization (GO:0051303)4.08906166
23* sister chromatid segregation (GO:0000819)4.08858111
24kinetochore organization (GO:0051383)4.06925361
25chromatin remodeling at centromere (GO:0031055)4.00491287
26mitotic nuclear envelope disassembly (GO:0007077)3.98108756
27folic acid-containing compound biosynthetic process (GO:0009396)3.88244109
28nucleotide-excision repair, DNA gap filling (GO:0006297)3.86530356
29DNA ligation (GO:0006266)3.86426221
30protein K6-linked ubiquitination (GO:0085020)3.84554360
31positive regulation of mitotic sister chromatid separation (GO:1901970)3.84091616
32positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.84091616
33positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.84091616
34telomere maintenance via telomere lengthening (GO:0010833)3.84084850
35positive regulation of chromosome segregation (GO:0051984)3.82123248
36regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.74265883
37attachment of spindle microtubules to kinetochore (GO:0008608)3.72943917
38non-recombinational repair (GO:0000726)3.72584461
39double-strand break repair via nonhomologous end joining (GO:0006303)3.72584461
40DNA duplex unwinding (GO:0032508)3.71725441
41DNA geometric change (GO:0032392)3.69437341
42membrane disassembly (GO:0030397)3.63803543
43nuclear envelope disassembly (GO:0051081)3.63803543
44purine nucleobase biosynthetic process (GO:0009113)3.63630072
45nuclear pore organization (GO:0006999)3.63109449
46kinetochore assembly (GO:0051382)3.62859717
47proteasome assembly (GO:0043248)3.57596782
48anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.56673362
49DNA replication-independent nucleosome organization (GO:0034724)3.54866819
50DNA replication-independent nucleosome assembly (GO:0006336)3.54866819
51mitotic spindle checkpoint (GO:0071174)3.53365867
52negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.52895712
53deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.52485355
54nuclear pore complex assembly (GO:0051292)3.52248585
55regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.49865591
56pore complex assembly (GO:0046931)3.49674275
57IMP metabolic process (GO:0046040)3.48902807
58telomere organization (GO:0032200)3.42454336
59telomere maintenance (GO:0000723)3.42310392
60DNA replication-dependent nucleosome organization (GO:0034723)3.39308018
61DNA replication-dependent nucleosome assembly (GO:0006335)3.39308018
62mitotic spindle assembly checkpoint (GO:0007094)3.38216550
63regulation of double-strand break repair via homologous recombination (GO:0010569)3.38178226
64* chromosome segregation (GO:0007059)3.32162375
65histone exchange (GO:0043486)3.31011918
66positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.30274880
67regulation of spindle organization (GO:0090224)3.25856579
68DNA conformation change (GO:0071103)3.25278250
69negative regulation of ligase activity (GO:0051352)3.22355216
70negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.22355216
71DNA topological change (GO:0006265)3.19376197
72ribosomal large subunit biogenesis (GO:0042273)3.18620902
73regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17033640
74regulation of mitotic metaphase/anaphase transition (GO:0030071)3.16727310
75regulation of centriole replication (GO:0046599)3.16167410
76regulation of chromosome segregation (GO:0051983)3.16091607
77ribosomal small subunit assembly (GO:0000028)3.14844525
78tRNA aminoacylation for protein translation (GO:0006418)3.11477699
79regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.10764440
80cullin deneddylation (GO:0010388)3.10682087
81regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.10139590
82somatic hypermutation of immunoglobulin genes (GO:0016446)3.09991013
83somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09991013
84snRNA processing (GO:0016180)3.09353479
85L-serine metabolic process (GO:0006563)3.09252340
86ribosome biogenesis (GO:0042254)3.07048069
87deoxyribonucleotide biosynthetic process (GO:0009263)3.05550331
88amino acid activation (GO:0043038)3.03198045
89tRNA aminoacylation (GO:0043039)3.03198045
90nucleobase-containing small molecule interconversion (GO:0015949)3.02840018
91spindle checkpoint (GO:0031577)3.02746774
92intra-S DNA damage checkpoint (GO:0031573)3.02026479
93regulation of mitotic sister chromatid separation (GO:0010965)3.00880920
94regulation of mitotic sister chromatid segregation (GO:0033047)3.00880920
95regulation of sister chromatid segregation (GO:0033045)3.00880920
96mismatch repair (GO:0006298)3.00633702
97maturation of SSU-rRNA (GO:0030490)3.00140608
98negative regulation of chromosome segregation (GO:0051985)2.99088128
99regulation of centrosome cycle (GO:0046605)2.96104456
100negative regulation of mitotic sister chromatid separation (GO:2000816)2.95336553
101negative regulation of mitotic sister chromatid segregation (GO:0033048)2.95336553
102negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.95336553
103negative regulation of sister chromatid segregation (GO:0033046)2.95336553
104* protein localization to chromosome (GO:0034502)2.95191728
105chromatin assembly or disassembly (GO:0006333)2.95173804
106base-excision repair (GO:0006284)2.94851914
107regulation of sister chromatid cohesion (GO:0007063)2.92332434
108formation of translation preinitiation complex (GO:0001731)2.92137790
109chromosome condensation (GO:0030261)2.92034682
110* mitotic cell cycle (GO:0000278)2.91478498
111regulation of mitotic spindle organization (GO:0060236)2.91200763
112ATP-dependent chromatin remodeling (GO:0043044)2.88458884
113protein deneddylation (GO:0000338)2.87784908
114negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87440408
115maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85744908
116translesion synthesis (GO:0019985)2.85218429
117mitotic sister chromatid cohesion (GO:0007064)2.85107511
118DNA synthesis involved in DNA repair (GO:0000731)2.84629176
119DNA packaging (GO:0006323)2.84388633
120histone H2A acetylation (GO:0043968)2.84368433
121spindle assembly checkpoint (GO:0071173)2.84304602
122regulation of translational fidelity (GO:0006450)2.83911392
123G1/S transition of mitotic cell cycle (GO:0000082)2.82754951
124cell cycle G1/S phase transition (GO:0044843)2.82754951
125transcription-coupled nucleotide-excision repair (GO:0006283)2.81975463
126positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.81613096
127nuclear envelope organization (GO:0006998)2.81159374
128protein complex localization (GO:0031503)2.81003316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.06600669
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.12433084
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.62121109
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.60246149
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.14131286
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99027661
7* EST1_17652178_ChIP-ChIP_JURKAT_Human2.74125573
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64951284
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55439627
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.48795909
11AR_21909140_ChIP-Seq_LNCAP_Human2.47686086
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47200276
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.47111676
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.38515637
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34128844
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29814119
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.29370270
18* ETS1_20019798_ChIP-Seq_JURKAT_Human2.29159897
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28173391
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.22168408
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.05808744
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05683933
23XRN2_22483619_ChIP-Seq_HELA_Human2.00526394
24E2F7_22180533_ChIP-Seq_HELA_Human10.3066291
25VDR_23849224_ChIP-Seq_CD4+_Human1.97359785
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96413644
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95738138
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95052278
29* FOXP3_21729870_ChIP-Seq_TREG_Human1.90520091
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84834624
31DCP1A_22483619_ChIP-Seq_HELA_Human1.81933225
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75252037
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75121327
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72291070
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70340839
36* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59368060
37MYC_22102868_ChIP-Seq_BL_Human1.59177104
38GABP_19822575_ChIP-Seq_HepG2_Human1.58997475
39ELK1_19687146_ChIP-ChIP_HELA_Human1.58886793
40TTF2_22483619_ChIP-Seq_HELA_Human1.58687077
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57359169
42* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55728770
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55607787
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55009233
45CIITA_25753668_ChIP-Seq_RAJI_Human1.54324385
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53935627
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51989243
48KDM5A_27292631_Chip-Seq_BREAST_Human1.49137026
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49002742
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47328582
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43734090
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.39513111
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.38569279
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37555924
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34254088
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33617868
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.32538463
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26543008
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25722699
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22882982
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20814186
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19251668
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19239903
64* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17153212
65SOX17_20123909_ChIP-Seq_XEN_Mouse1.16459222
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16338506
67MYC_18940864_ChIP-ChIP_HL60_Human1.16266441
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15223344
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12815142
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11460512
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.06826687
72* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05441928
73TFEB_21752829_ChIP-Seq_HELA_Human1.04279603
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04058378
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01862490
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00294058
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98117825
78STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94067737
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93976217
80SPI1_23547873_ChIP-Seq_NB4_Human0.93265758
81VDR_21846776_ChIP-Seq_THP-1_Human0.92630991
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92585362
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91868229
84SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90861145
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89657245
86TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88121820
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87427180
88CHD1_26751641_Chip-Seq_LNCaP_Human0.86575329
89ELK1_22589737_ChIP-Seq_MCF10A_Human0.86247072
90* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84511383
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84446579
92SALL1_21062744_ChIP-ChIP_HESCs_Human0.84395569
93* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83503906
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83262818
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82890596
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81851405
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81152355
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79659787
99* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79323904
100* NANOG_21062744_ChIP-ChIP_HESCs_Human0.79175312
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.77426683
102NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.76207474
103* MYB_26560356_Chip-Seq_TH1_Human0.75586102
104EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.75523089
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.75030758
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.74940314
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.74706944
108NOTCH1_21737748_ChIP-Seq_TLL_Human0.74159183
109ELF5_23300383_ChIP-Seq_T47D_Human0.73996686
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.73941915
111SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.73412907
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71650327
113E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.69827250
114TBX5_21415370_ChIP-Seq_HL-1_Mouse0.67640845
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.66806920
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.66642188

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.15719560
2MP0003693_abnormal_embryo_hatching5.01618690
3MP0003111_abnormal_nucleus_morphology4.70592095
4MP0004957_abnormal_blastocyst_morpholog4.13703916
5MP0003077_abnormal_cell_cycle4.04194671
6MP0008058_abnormal_DNA_repair3.38569140
7MP0008057_abnormal_DNA_replication3.35509908
8MP0008007_abnormal_cellular_replicative2.98021996
9MP0008877_abnormal_DNA_methylation2.47562229
10MP0008932_abnormal_embryonic_tissue2.36054583
11MP0002396_abnormal_hematopoietic_system2.28775035
12MP0000350_abnormal_cell_proliferation2.18371047
13MP0003941_abnormal_skin_development2.17539149
14MP0001730_embryonic_growth_arrest2.06619069
15MP0003786_premature_aging2.00265073
16MP0003806_abnormal_nucleotide_metabolis1.97003783
17MP0003123_paternal_imprinting1.83082029
18MP0010352_gastrointestinal_tract_polyps1.72195248
19MP0001293_anophthalmia1.66826017
20MP0000490_abnormal_crypts_of1.64812118
21MP0001672_abnormal_embryogenesis/_devel1.62619205
22MP0005380_embryogenesis_phenotype1.62619205
23MP0003763_abnormal_thymus_physiology1.60501374
24MP0000313_abnormal_cell_death1.60071610
25MP0004233_abnormal_muscle_weight1.58774036
26MP0010307_abnormal_tumor_latency1.54831692
27MP0006292_abnormal_olfactory_placode1.49133287
28MP0003950_abnormal_plasma_membrane1.49090066
29MP0003718_maternal_effect1.48320940
30MP0002019_abnormal_tumor_incidence1.47666206
31MP0001697_abnormal_embryo_size1.47321110
32MP0003984_embryonic_growth_retardation1.46836012
33MP0002102_abnormal_ear_morphology1.46519699
34MP0000537_abnormal_urethra_morphology1.42063082
35MP0002088_abnormal_embryonic_growth/wei1.41850984
36MP0003566_abnormal_cell_adhesion1.39841936
37MP0003221_abnormal_cardiomyocyte_apopto1.39400917
38MP0008260_abnormal_autophagy1.38886069
39MP0004808_abnormal_hematopoietic_stem1.35897282
40MP0002080_prenatal_lethality1.34977021
41MP0003186_abnormal_redox_activity1.33664810
42MP0010030_abnormal_orbit_morphology1.32183815
43MP0002085_abnormal_embryonic_tissue1.31160329
44MP0000703_abnormal_thymus_morphology1.25882818
45MP0003385_abnormal_body_wall1.24914313
46MP0003121_genomic_imprinting1.24086615
47MP0002398_abnormal_bone_marrow1.24024320
48MP0002697_abnormal_eye_size1.21705622
49MP0002086_abnormal_extraembryonic_tissu1.19689925
50MP0004272_abnormal_basement_membrane1.16633398
51MP0002084_abnormal_developmental_patter1.16077467
52MP0004147_increased_porphyrin_level1.13370607
53MP0003705_abnormal_hypodermis_morpholog1.13178036
54MP0002796_impaired_skin_barrier1.11564705
55MP0009840_abnormal_foam_cell1.11516211
56MP0009672_abnormal_birth_weight1.11421359
57MP0005501_abnormal_skin_physiology1.10765851
58MP0002722_abnormal_immune_system1.10598341
59MP0002092_abnormal_eye_morphology1.09653961
60MP0002132_abnormal_respiratory_system1.09144427
61MP0004197_abnormal_fetal_growth/weight/1.08773367
62MP0010234_abnormal_vibrissa_follicle1.07846576
63MP0001119_abnormal_female_reproductive1.06869274
64MP0000689_abnormal_spleen_morphology1.06009309
65MP0003890_abnormal_embryonic-extraembry1.05295902
66MP0002877_abnormal_melanocyte_morpholog1.04790366
67MP0002210_abnormal_sex_determination1.04412347
68MP0009053_abnormal_anal_canal1.03211942
69MP0009697_abnormal_copulation1.01953281
70MP0006036_abnormal_mitochondrial_physio1.01838383
71MP0000428_abnormal_craniofacial_morphol1.01825106
72MP0002060_abnormal_skin_morphology0.99334703
73MP0002653_abnormal_ependyma_morphology0.98435991
74MP0005394_taste/olfaction_phenotype0.98257591
75MP0005499_abnormal_olfactory_system0.98257591
76MP0000579_abnormal_nail_morphology0.98042274
77MP0006054_spinal_hemorrhage0.97887405
78MP0000566_synostosis0.96535039
79MP0005075_abnormal_melanosome_morpholog0.96416553
80MP0001727_abnormal_embryo_implantation0.95481180
81MP0005174_abnormal_tail_pigmentation0.95021110
82MP0005623_abnormal_meninges_morphology0.94163457
83MP0001929_abnormal_gametogenesis0.93100958
84MP0001881_abnormal_mammary_gland0.93052211
85MP0002429_abnormal_blood_cell0.92704520
86MP0002233_abnormal_nose_morphology0.92690011
87MP0001286_abnormal_eye_development0.92062454
88MP0001915_intracranial_hemorrhage0.89634702
89MP0009333_abnormal_splenocyte_physiolog0.89631550
90MP0001529_abnormal_vocalization0.89615122
91MP0001346_abnormal_lacrimal_gland0.89475186
92MP0004782_abnormal_surfactant_physiolog0.89371690
93MP0000716_abnormal_immune_system0.85576775
94MP0005384_cellular_phenotype0.85509598
95MP0000685_abnormal_immune_system0.85249904
96MP0001661_extended_life_span0.84580633
97MP0001835_abnormal_antigen_presentation0.84567542
98MP0001145_abnormal_male_reproductive0.84079079
99MP0005671_abnormal_response_to0.83421857
100MP0003943_abnormal_hepatobiliary_system0.82705043
101MP0005621_abnormal_cell_physiology0.82113985
102MP0000653_abnormal_sex_gland0.82043214
103MP0000358_abnormal_cell_content/0.82039536
104MP0003315_abnormal_perineum_morphology0.80351928
105MP0002095_abnormal_skin_pigmentation0.80199857
106MP0001299_abnormal_eye_distance/0.80171976
107MP0000647_abnormal_sebaceous_gland0.79963257
108MP0005076_abnormal_cell_differentiation0.79925684
109MP0001216_abnormal_epidermal_layer0.79919057
110MP0004264_abnormal_extraembryonic_tissu0.78662631
111MP0001853_heart_inflammation0.78177026
112MP0003567_abnormal_fetal_cardiomyocyte0.78087798
113MP0001800_abnormal_humoral_immune0.77948094
114MP0008789_abnormal_olfactory_epithelium0.77375719
115MP0000627_abnormal_mammary_gland0.76641817
116MP0003787_abnormal_imprinting0.75886405
117MP0002111_abnormal_tail_morphology0.75625784
118MP0000371_diluted_coat_color0.75607137
119MP0001243_abnormal_dermal_layer0.75305569
120MP0003656_abnormal_erythrocyte_physiolo0.74441907
121MP0002075_abnormal_coat/hair_pigmentati0.74283217
122MP0001545_abnormal_hematopoietic_system0.72754653
123MP0005397_hematopoietic_system_phenotyp0.72754653
124MP0001186_pigmentation_phenotype0.72609674
125MP0005023_abnormal_wound_healing0.71747800
126MP0000762_abnormal_tongue_morphology0.71317535
127MP0005248_abnormal_Harderian_gland0.71307798
128MP0002098_abnormal_vibrissa_morphology0.71015814
129MP0006035_abnormal_mitochondrial_morpho0.67996788
130MP0003937_abnormal_limbs/digits/tail_de0.67930736
131MP0003938_abnormal_ear_development0.67742593
132MP0002420_abnormal_adaptive_immunity0.67737537
133MP0005408_hypopigmentation0.67662814
134MP0003755_abnormal_palate_morphology0.67536245
135MP0010678_abnormal_skin_adnexa0.67185797
136MP0002177_abnormal_outer_ear0.67092852
137MP0001819_abnormal_immune_cell0.66939329
138MP0009703_decreased_birth_body0.66699415
139MP0000015_abnormal_ear_pigmentation0.66557453
140MP0003699_abnormal_female_reproductive0.66161447
141MP0002405_respiratory_system_inflammati0.66085726
142MP0002282_abnormal_trachea_morphology0.65994958
143MP0000432_abnormal_head_morphology0.65735152
144MP0005197_abnormal_uvea_morphology0.65666943
145MP0002452_abnormal_antigen_presenting0.64163901
146MP0003119_abnormal_digestive_system0.63792446
147MP0002938_white_spotting0.62205617
148MP0009250_abnormal_appendicular_skeleto0.61984833

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.26765024
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.06943811
3Degeneration of anterior horn cells (HP:0002398)4.37722450
4Abnormality of the anterior horn cell (HP:0006802)4.37722450
5Cortical dysplasia (HP:0002539)4.14150210
6Birth length less than 3rd percentile (HP:0003561)3.89551258
7Increased serum pyruvate (HP:0003542)3.68234860
8Reticulocytopenia (HP:0001896)3.56864284
9Abnormality of chromosome stability (HP:0003220)3.44984095
10Abnormality of the preputium (HP:0100587)3.42732615
11Ectopic kidney (HP:0000086)3.41224901
12Abnormality of glycolysis (HP:0004366)3.38408746
13Multiple enchondromatosis (HP:0005701)3.33401280
1411 pairs of ribs (HP:0000878)3.32244172
15Meckel diverticulum (HP:0002245)3.32145340
16Aplasia/Hypoplasia of the patella (HP:0006498)3.29751376
17Abnormality of the ileum (HP:0001549)3.22181889
18Aplasia/Hypoplasia of the uvula (HP:0010293)3.14392593
19Patellar aplasia (HP:0006443)2.99324122
20Colon cancer (HP:0003003)2.89982989
21Myelodysplasia (HP:0002863)2.88349884
22Selective tooth agenesis (HP:0001592)2.82452771
23Premature graying of hair (HP:0002216)2.82384318
24Absent thumb (HP:0009777)2.79922732
25Bone marrow hypocellularity (HP:0005528)2.72970069
26Oral leukoplakia (HP:0002745)2.68576221
27Small intestinal stenosis (HP:0012848)2.67181247
28Duodenal stenosis (HP:0100867)2.67181247
29Carpal bone hypoplasia (HP:0001498)2.65740000
30Medulloblastoma (HP:0002885)2.65401101
31Agnosia (HP:0010524)2.61699685
32Absent radius (HP:0003974)2.60016463
33Mesomelia (HP:0003027)2.59835705
34Abnormality of cells of the erythroid lineage (HP:0012130)2.59358382
35Breast hypoplasia (HP:0003187)2.57360914
36Abnormality of DNA repair (HP:0003254)2.53666914
37Duplicated collecting system (HP:0000081)2.49954995
38Sloping forehead (HP:0000340)2.49889562
39Spastic diplegia (HP:0001264)2.48608889
40Abnormal number of erythroid precursors (HP:0012131)2.48019461
41Abnormality of the carotid arteries (HP:0005344)2.43129839
42Rough bone trabeculation (HP:0100670)2.42320912
43Ependymoma (HP:0002888)2.41597420
44Abnormality of the umbilical cord (HP:0010881)2.35661244
45Aplastic anemia (HP:0001915)2.35654152
46Short thumb (HP:0009778)2.34482014
47Absent forearm bone (HP:0003953)2.34129232
48Aplasia involving forearm bones (HP:0009822)2.34129232
49Microvesicular hepatic steatosis (HP:0001414)2.33333872
50Abnormality of the fetal cardiovascular system (HP:0010948)2.33053236
51Abnormal umbilical cord blood vessels (HP:0011403)2.33053236
52Single umbilical artery (HP:0001195)2.33053236
53Abnormality of pyrimidine metabolism (HP:0004353)2.32827156
54High anterior hairline (HP:0009890)2.32124704
55Spinal muscular atrophy (HP:0007269)2.29191949
56Atrophy/Degeneration involving motor neurons (HP:0007373)2.27009938
57Impulsivity (HP:0100710)2.26534761
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26040022
59Abnormality of the renal collecting system (HP:0004742)2.23274356
60Hypoplasia of the capital femoral epiphysis (HP:0003090)2.20930985
61Abnormality of the labia minora (HP:0012880)2.19752113
62Abnormalities of placenta or umbilical cord (HP:0001194)2.18420223
63Intestinal fistula (HP:0100819)2.17394890
64Cellular immunodeficiency (HP:0005374)2.15826377
65Basal cell carcinoma (HP:0002671)2.13917076
66Secondary amenorrhea (HP:0000869)2.13678600
67Deviation of the thumb (HP:0009603)2.12065281
68Clubbing of toes (HP:0100760)2.12009907
69Cafe-au-lait spot (HP:0000957)2.10116237
70Rhabdomyosarcoma (HP:0002859)2.09837703
71Abnormality of the duodenum (HP:0002246)2.09781669
72Volvulus (HP:0002580)2.09256341
73Entropion (HP:0000621)2.05992130
74Horseshoe kidney (HP:0000085)2.04835822
75Progressive external ophthalmoplegia (HP:0000590)2.04799674
76Abnormal lung lobation (HP:0002101)2.04465054
77Tracheoesophageal fistula (HP:0002575)2.03360437
78Increased nuchal translucency (HP:0010880)2.01502424
79Prominent metopic ridge (HP:0005487)2.01081127
80Lymphoma (HP:0002665)1.98650014
81Missing ribs (HP:0000921)1.97773313
82Thrombocytosis (HP:0001894)1.96131363
83Triphalangeal thumb (HP:0001199)1.96055631
84Rectovaginal fistula (HP:0000143)1.95347324
85Rectal fistula (HP:0100590)1.95347324
86Proximal placement of thumb (HP:0009623)1.95052736
87Neoplasm of the colon (HP:0100273)1.94754287
88Premature rupture of membranes (HP:0001788)1.92553492
89Short 4th metacarpal (HP:0010044)1.92412317
90Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.92412317
91Facial cleft (HP:0002006)1.92080875
92Deep philtrum (HP:0002002)1.90720885
93Abnormality of the metopic suture (HP:0005556)1.90591078
94Short middle phalanx of the 5th finger (HP:0004220)1.90015234
95Carpal synostosis (HP:0009702)1.89456921
96Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86486090
97Choanal atresia (HP:0000453)1.85287726
98Poikiloderma (HP:0001029)1.84859164
99Insidious onset (HP:0003587)1.83307598
100Termporal pattern (HP:0011008)1.83307598
101Flared metaphyses (HP:0003015)1.83218410
102Abnormality of chromosome segregation (HP:0002916)1.82491648
103Stenosis of the external auditory canal (HP:0000402)1.82071863
104Nephroblastoma (Wilms tumor) (HP:0002667)1.81775482
105Lip pit (HP:0100267)1.81637127
106Trismus (HP:0000211)1.81588463
107Microretrognathia (HP:0000308)1.81312249
108Amniotic constriction ring (HP:0009775)1.81257413
109Abnormality of placental membranes (HP:0011409)1.81257413
110Supernumerary spleens (HP:0009799)1.79406801
111Postnatal microcephaly (HP:0005484)1.78928254
112Progressive muscle weakness (HP:0003323)1.78903466
113Irregular epiphyses (HP:0010582)1.77981637
114Microglossia (HP:0000171)1.75455466
115Abnormal trabecular bone morphology (HP:0100671)1.74940353
116Astrocytoma (HP:0009592)1.74824741
117Abnormality of the astrocytes (HP:0100707)1.74824741
118Abnormality of methionine metabolism (HP:0010901)1.74425313
119Broad palm (HP:0001169)1.73897324
120Orthostatic hypotension (HP:0001278)1.72008329
121Type I transferrin isoform profile (HP:0003642)1.71495377
122Vaginal fistula (HP:0004320)1.71235590
123Absent epiphyses (HP:0010577)1.70615929
124Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.70615929
125Neoplasm of the peripheral nervous system (HP:0100007)1.70452429
126Bifid tongue (HP:0010297)1.70351127
127Upper limb muscle weakness (HP:0003484)1.70031868
128Abnormal number of incisors (HP:0011064)1.69744771
129Syringomyelia (HP:0003396)1.68808219
130Spinal cord lesions (HP:0100561)1.68808219
131Aplasia/hypoplasia of the humerus (HP:0006507)1.68302430
132Increased serum lactate (HP:0002151)1.67903938
133Glioma (HP:0009733)1.67583206
134Pancytopenia (HP:0001876)1.67211681
135Abnormal mitochondria in muscle tissue (HP:0008316)1.66934706
136Neoplasm of the pancreas (HP:0002894)1.66675153
137Cerebral hypomyelination (HP:0006808)1.66442726
138Cleft eyelid (HP:0000625)1.65969042
139Increased hepatocellular lipid droplets (HP:0006565)1.65951867
140Embryonal renal neoplasm (HP:0011794)1.64071324
141Leukopenia (HP:0001882)1.63909780
142Recurrent viral infections (HP:0004429)1.63244385
143Overlapping toe (HP:0001845)1.62482905
144Hypoplastic pelvis (HP:0008839)1.61740796
145Abnormal protein glycosylation (HP:0012346)1.61440893
146Abnormal glycosylation (HP:0012345)1.61440893
147Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.61440893
148Abnormal protein N-linked glycosylation (HP:0012347)1.61440893
149Exercise-induced muscle cramps (HP:0003710)1.61047309
150Posterior subcapsular cataract (HP:0007787)1.60012122
151Hepatocellular necrosis (HP:0001404)1.58034315
152Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.57227518
153Abnormality of alanine metabolism (HP:0010916)1.57227518
154Hyperalaninemia (HP:0003348)1.57227518
155Shoulder girdle muscle weakness (HP:0003547)1.56570754
156Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.56564486
157Papillary thyroid carcinoma (HP:0002895)1.55749952

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.24265253
2CDC74.15350826
3EIF2AK13.66699782
4WEE13.64810731
5PBK3.62542905
6SRPK13.45382106
7NEK22.52100564
8TTK2.18764913
9BRSK22.15898386
10TSSK62.08252039
11PLK12.06228245
12MST41.97639172
13CCNB11.97141941
14PASK1.96281272
15BRSK11.94962697
16VRK21.94339182
17ATR1.92778210
18STK101.84342982
19NEK11.82802342
20RPS6KB21.82365484
21AURKB1.74307953
22ZAK1.73561265
23EIF2AK31.72866278
24ACVR1B1.71581887
25MKNK11.71281279
26PLK41.62251148
27MAP4K11.60636985
28MAP3K121.58125437
29CDK41.55349341
30PLK31.53236669
31RPS6KA41.51961876
32VRK11.46990117
33TRIM281.43473793
34CHEK21.42513273
35ERBB41.41560196
36EEF2K1.40659960
37CHEK11.40465201
38STK161.37431770
39CDK121.36799804
40STK41.32959139
41TAF11.28448258
42CDK71.27112066
43AURKA1.23714773
44TLK11.18052197
45MAP3K81.16770395
46EIF2AK21.12604526
47TEC1.12088453
48MKNK21.10949320
49IRAK41.05312979
50PDK21.03985426
51MST1R0.98506750
52LATS20.97839304
53BMPR1B0.96108710
54BCR0.95448802
55ATM0.92875588
56LATS10.91018437
57CLK10.85445491
58CDK20.85370624
59STK240.81830538
60TESK20.80923843
61BRAF0.79220749
62BTK0.78413028
63MAP2K30.78385375
64EPHA20.77673745
65CDK60.77417785
66NME10.77077479
67PIM10.77017039
68SMG10.76653283
69TGFBR10.76112101
70JAK30.74631449
71TXK0.73494865
72PAK40.71565566
73BRD40.71046450
74CDK80.70934766
75MAP3K140.70519853
76NEK90.69913623
77MAP3K110.68565355
78CDK10.67048049
79CSNK2A10.66171213
80DYRK30.66016579
81ALK0.65908365
82AKT30.64545920
83TYK20.63656013
84ERBB30.63154461
85NME20.62534056
86NUAK10.62349133
87STK30.60023031
88MAP3K100.59734902
89FGFR10.56797371
90ILK0.55956599
91MELK0.55917538
92CSNK2A20.55248798
93TRPM70.55205032
94SCYL20.54580222
95ICK0.54410055
96IRAK30.54408760
97TAOK30.53150440
98BCKDK0.52721157
99TESK10.52533143
100DMPK0.52473199
101PIM20.52435005
102CDK90.51805166
103EPHB20.51216784
104MAP3K30.49728118
105MAP4K20.48642856
106PKN20.47564497
107LIMK10.47257316
108RAF10.45807286
109MAPKAPK30.45047532
110NLK0.45044827
111MET0.44700319
112CHUK0.44373337
113RPS6KA50.42192757
114PAK10.41938004
115PRKCI0.41623095
116MAPKAPK20.41517202
117SIK30.40746264
118CSNK1G10.39998995
119CSNK1E0.37777879
120FLT30.37746126
121PRKDC0.37680976
122PAK20.37446808
123RPS6KA60.35364043
124DAPK10.34862534
125MAPK140.34260421
126STK38L0.34177521
127IKBKB0.34018542
128ITK0.33913736
129CDK180.32842294
130RPS6KL10.32134994
131RPS6KC10.32134994
132YES10.31714165
133LRRK20.30855179
134AKT10.30473299
135KIT0.30131800
136RPS6KB10.29297637

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.24957233
2Mismatch repair_Homo sapiens_hsa034304.31247784
3Homologous recombination_Homo sapiens_hsa034403.63437132
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.42977248
5Base excision repair_Homo sapiens_hsa034103.41918073
6One carbon pool by folate_Homo sapiens_hsa006703.18219835
7Cell cycle_Homo sapiens_hsa041102.95177481
8Spliceosome_Homo sapiens_hsa030402.94284971
9RNA transport_Homo sapiens_hsa030132.85629379
10Fanconi anemia pathway_Homo sapiens_hsa034602.74895971
11Proteasome_Homo sapiens_hsa030502.74447378
12Nucleotide excision repair_Homo sapiens_hsa034202.72865893
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.59561028
14RNA polymerase_Homo sapiens_hsa030202.42695336
15Non-homologous end-joining_Homo sapiens_hsa034502.31314792
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.24636941
17Pyrimidine metabolism_Homo sapiens_hsa002402.24098180
18Ribosome_Homo sapiens_hsa030102.07617647
19RNA degradation_Homo sapiens_hsa030181.98405579
20mRNA surveillance pathway_Homo sapiens_hsa030151.72920702
21p53 signaling pathway_Homo sapiens_hsa041151.69661237
22Pyruvate metabolism_Homo sapiens_hsa006201.64812010
23Steroid biosynthesis_Homo sapiens_hsa001001.58647862
24Basal transcription factors_Homo sapiens_hsa030221.52013711
25Epstein-Barr virus infection_Homo sapiens_hsa051691.29310011
26Herpes simplex infection_Homo sapiens_hsa051681.25393677
27Systemic lupus erythematosus_Homo sapiens_hsa053221.20259145
28Fatty acid elongation_Homo sapiens_hsa000621.18806472
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18744963
30Purine metabolism_Homo sapiens_hsa002301.11900250
31Primary immunodeficiency_Homo sapiens_hsa053401.11428491
32Propanoate metabolism_Homo sapiens_hsa006401.05577498
33Viral carcinogenesis_Homo sapiens_hsa052031.03656128
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.02068243
35Antigen processing and presentation_Homo sapiens_hsa046120.99469745
36Drug metabolism - other enzymes_Homo sapiens_hsa009830.96576205
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96504181
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95887383
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94601475
40Biosynthesis of amino acids_Homo sapiens_hsa012300.93989472
41Selenocompound metabolism_Homo sapiens_hsa004500.86110217
42NF-kappa B signaling pathway_Homo sapiens_hsa040640.83095764
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81931002
44Parkinsons disease_Homo sapiens_hsa050120.81198755
45HTLV-I infection_Homo sapiens_hsa051660.81171923
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75984768
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75780535
48Huntingtons disease_Homo sapiens_hsa050160.75039127
49Measles_Homo sapiens_hsa051620.72860323
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72312088
51Pentose phosphate pathway_Homo sapiens_hsa000300.71454616
52Oxidative phosphorylation_Homo sapiens_hsa001900.71429749
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71292019
54Small cell lung cancer_Homo sapiens_hsa052220.70685930
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69375531
56Oocyte meiosis_Homo sapiens_hsa041140.68206440
57N-Glycan biosynthesis_Homo sapiens_hsa005100.65620598
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64846033
59Adherens junction_Homo sapiens_hsa045200.62323748
60Glutathione metabolism_Homo sapiens_hsa004800.61266329
61Protein export_Homo sapiens_hsa030600.59381865
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58960968
63Apoptosis_Homo sapiens_hsa042100.55875207
64Legionellosis_Homo sapiens_hsa051340.55223893
65Fatty acid metabolism_Homo sapiens_hsa012120.54472799
66Carbon metabolism_Homo sapiens_hsa012000.53311355
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49522125
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.48667245
69Bladder cancer_Homo sapiens_hsa052190.47617570
70Influenza A_Homo sapiens_hsa051640.47526719
71Lysine degradation_Homo sapiens_hsa003100.47177444
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46643650
73Fructose and mannose metabolism_Homo sapiens_hsa000510.46277193
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45416089
75Allograft rejection_Homo sapiens_hsa053300.45011123
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.44421525
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43587139
78Vitamin B6 metabolism_Homo sapiens_hsa007500.43309958
79MicroRNAs in cancer_Homo sapiens_hsa052060.42995805
80TGF-beta signaling pathway_Homo sapiens_hsa043500.42726545
81Folate biosynthesis_Homo sapiens_hsa007900.41887634
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41427761
83Fatty acid degradation_Homo sapiens_hsa000710.40206247
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38674982
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38500555
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38325651
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34405168
88Hepatitis B_Homo sapiens_hsa051610.33342757
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32337565
90Sulfur relay system_Homo sapiens_hsa041220.32097970
91Peroxisome_Homo sapiens_hsa041460.31444404
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31173112
93Notch signaling pathway_Homo sapiens_hsa043300.31039858
94Hematopoietic cell lineage_Homo sapiens_hsa046400.29574625
95Thyroid cancer_Homo sapiens_hsa052160.29481942
96Alzheimers disease_Homo sapiens_hsa050100.28149769
97Chronic myeloid leukemia_Homo sapiens_hsa052200.27481616
98Shigellosis_Homo sapiens_hsa051310.27454100
99Galactose metabolism_Homo sapiens_hsa000520.26594716
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26212935
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25864497
102Basal cell carcinoma_Homo sapiens_hsa052170.25682344
103Autoimmune thyroid disease_Homo sapiens_hsa053200.23721572
104Proteoglycans in cancer_Homo sapiens_hsa052050.23257947
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23108053
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.22577453
107Leishmaniasis_Homo sapiens_hsa051400.21328347
108Vibrio cholerae infection_Homo sapiens_hsa051100.21209298
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19709974
110Pancreatic cancer_Homo sapiens_hsa052120.19676452
111Prostate cancer_Homo sapiens_hsa052150.19392931
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18807097
113Alcoholism_Homo sapiens_hsa050340.18501051
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.18118366
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18021892
116Hippo signaling pathway_Homo sapiens_hsa043900.17954769
117HIF-1 signaling pathway_Homo sapiens_hsa040660.17919256
118Wnt signaling pathway_Homo sapiens_hsa043100.17450347
119Metabolic pathways_Homo sapiens_hsa011000.17396102
120Colorectal cancer_Homo sapiens_hsa052100.16746053
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.16600253
122Viral myocarditis_Homo sapiens_hsa054160.15975983
123Acute myeloid leukemia_Homo sapiens_hsa052210.15745714
124Arginine and proline metabolism_Homo sapiens_hsa003300.14434697
125B cell receptor signaling pathway_Homo sapiens_hsa046620.14250373
126Renin-angiotensin system_Homo sapiens_hsa046140.13981319
127Type I diabetes mellitus_Homo sapiens_hsa049400.13952629
128Pathways in cancer_Homo sapiens_hsa052000.12819617
129Arachidonic acid metabolism_Homo sapiens_hsa005900.12139384
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.11323047

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