

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | protein localization to kinetochore (GO:0034501) | 5.41469116 |
| 2 | mitotic metaphase plate congression (GO:0007080) | 5.01700070 |
| 3 | DNA unwinding involved in DNA replication (GO:0006268) | 4.91973235 |
| 4 | nuclear pore organization (GO:0006999) | 4.91455870 |
| 5 | nuclear pore complex assembly (GO:0051292) | 4.79949460 |
| 6 | DNA replication initiation (GO:0006270) | 4.71993019 |
| 7 | protein localization to chromosome, centromeric region (GO:0071459) | 4.69809727 |
| 8 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.63905886 |
| 9 | establishment of integrated proviral latency (GO:0075713) | 4.62937820 |
| 10 | kinetochore organization (GO:0051383) | 4.60202059 |
| 11 | mitotic sister chromatid segregation (GO:0000070) | 4.58118352 |
| 12 | metaphase plate congression (GO:0051310) | 4.48112360 |
| 13 | DNA replication checkpoint (GO:0000076) | 4.43377925 |
| 14 | chromatin remodeling at centromere (GO:0031055) | 4.42343888 |
| 15 | DNA strand elongation (GO:0022616) | 4.41835054 |
| 16 | mitotic chromosome condensation (GO:0007076) | 4.41277864 |
| 17 | mitotic nuclear envelope disassembly (GO:0007077) | 4.37210629 |
| 18 | CENP-A containing nucleosome assembly (GO:0034080) | 4.34945904 |
| 19 | sister chromatid segregation (GO:0000819) | 4.30401535 |
| 20 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.28030197 |
| 21 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.22883975 |
| 22 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.22883975 |
| 23 | attachment of spindle microtubules to kinetochore (GO:0008608) | 4.10686505 |
| 24 | regulation of spindle organization (GO:0090224) | 4.09186077 |
| 25 | establishment of chromosome localization (GO:0051303) | 4.07118606 |
| 26 | membrane disassembly (GO:0030397) | 4.06791129 |
| 27 | nuclear envelope disassembly (GO:0051081) | 4.06791129 |
| 28 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 4.04807569 |
| 29 | DNA replication-independent nucleosome organization (GO:0034724) | 4.02821413 |
| 30 | DNA replication-independent nucleosome assembly (GO:0006336) | 4.02821413 |
| 31 | mitotic recombination (GO:0006312) | 4.02032311 |
| 32 | proteasome assembly (GO:0043248) | 3.99767044 |
| 33 | kinetochore assembly (GO:0051382) | 3.98390955 |
| 34 | telomere maintenance via recombination (GO:0000722) | 3.97098439 |
| 35 | meiotic chromosome segregation (GO:0045132) | 3.88455451 |
| 36 | nucleobase biosynthetic process (GO:0046112) | 3.88372098 |
| 37 | IMP biosynthetic process (GO:0006188) | 3.86057020 |
| 38 | histone exchange (GO:0043486) | 3.82132610 |
| 39 | DNA ligation (GO:0006266) | 3.78248780 |
| 40 | positive regulation of chromosome segregation (GO:0051984) | 3.75737060 |
| 41 | pore complex assembly (GO:0046931) | 3.73483838 |
| 42 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.72453423 |
| 43 | protein K6-linked ubiquitination (GO:0085020) | 3.69573445 |
| 44 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.66137116 |
| 45 | regulation of mitotic spindle organization (GO:0060236) | 3.65095590 |
| 46 | mitotic sister chromatid cohesion (GO:0007064) | 3.64743954 |
| 47 | telomere maintenance via telomere lengthening (GO:0010833) | 3.63321790 |
| 48 | DNA geometric change (GO:0032392) | 3.63149806 |
| 49 | DNA duplex unwinding (GO:0032508) | 3.61898025 |
| 50 | purine nucleobase biosynthetic process (GO:0009113) | 3.61746445 |
| 51 | DNA double-strand break processing (GO:0000729) | 3.60275482 |
| 52 | formation of translation preinitiation complex (GO:0001731) | 3.56361642 |
| 53 | spindle checkpoint (GO:0031577) | 3.55403802 |
| 54 | regulation of chromosome segregation (GO:0051983) | 3.53953575 |
| 55 | protein localization to chromosome (GO:0034502) | 3.50407392 |
| 56 | regulation of centrosome cycle (GO:0046605) | 3.48213013 |
| 57 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.46971532 |
| 58 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.46971532 |
| 59 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.46971532 |
| 60 | establishment of viral latency (GO:0019043) | 3.45284875 |
| 61 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.43406634 |
| 62 | negative regulation of chromosome segregation (GO:0051985) | 3.41210014 |
| 63 | chromosome segregation (GO:0007059) | 3.40867974 |
| 64 | maturation of SSU-rRNA (GO:0030490) | 3.40313224 |
| 65 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.38362048 |
| 66 | chromatin assembly or disassembly (GO:0006333) | 3.37958851 |
| 67 | IMP metabolic process (GO:0046040) | 3.35909509 |
| 68 | spindle assembly checkpoint (GO:0071173) | 3.35713478 |
| 69 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.34976522 |
| 70 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.34976522 |
| 71 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.34976522 |
| 72 | negative regulation of sister chromatid segregation (GO:0033046) | 3.34976522 |
| 73 | regulation of histone H3-K9 methylation (GO:0051570) | 3.34861264 |
| 74 | regulation of centriole replication (GO:0046599) | 3.34384609 |
| 75 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.34070862 |
| 76 | non-recombinational repair (GO:0000726) | 3.34070862 |
| 77 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.33991144 |
| 78 | regulation of sister chromatid cohesion (GO:0007063) | 3.32164658 |
| 79 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.31396916 |
| 80 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.31396916 |
| 81 | ribosome assembly (GO:0042255) | 3.31202431 |
| 82 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.31011652 |
| 83 | mitotic spindle checkpoint (GO:0071174) | 3.30335633 |
| 84 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.29136656 |
| 85 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.29136656 |
| 86 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.28087051 |
| 87 | mitotic spindle assembly checkpoint (GO:0007094) | 3.27550886 |
| 88 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.26269186 |
| 89 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.25563818 |
| 90 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.24873095 |
| 91 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.23540585 |
| 92 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.23068973 |
| 93 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.23068973 |
| 94 | regulation of sister chromatid segregation (GO:0033045) | 3.23068973 |
| 95 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.21318230 |
| 96 | heterochromatin organization (GO:0070828) | 3.20826736 |
| 97 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.19048505 |
| 98 | DNA conformation change (GO:0071103) | 3.18845920 |
| 99 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.17752766 |
| 100 | chromosome condensation (GO:0030261) | 3.11757033 |
| 101 | replication fork processing (GO:0031297) | 3.11288585 |
| 102 | nuclear envelope organization (GO:0006998) | 3.11217928 |
| 103 | DNA damage response, detection of DNA damage (GO:0042769) | 3.10956428 |
| 104 | ATP-dependent chromatin remodeling (GO:0043044) | 3.08820145 |
| 105 | regulation of helicase activity (GO:0051095) | 3.08100607 |
| 106 | DNA topological change (GO:0006265) | 3.07998580 |
| 107 | ribosome biogenesis (GO:0042254) | 3.07577913 |
| 108 | postreplication repair (GO:0006301) | 3.07292868 |
| 109 | regulation of DNA endoreduplication (GO:0032875) | 3.06891651 |
| 110 | regulation of gene silencing by RNA (GO:0060966) | 3.05917001 |
| 111 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.05917001 |
| 112 | regulation of gene silencing by miRNA (GO:0060964) | 3.05917001 |
| 113 | telomere maintenance (GO:0000723) | 3.04376092 |
| 114 | mismatch repair (GO:0006298) | 3.03607700 |
| 115 | telomere organization (GO:0032200) | 3.03124829 |
| 116 | L-serine metabolic process (GO:0006563) | 3.01158790 |
| 117 | negative regulation of histone methylation (GO:0031061) | 3.00794893 |
| 118 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.99538815 |
| 119 | negative regulation of ligase activity (GO:0051352) | 2.98883012 |
| 120 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.98883012 |
| 121 | regulation of telomere maintenance via telomerase (GO:0032210) | 2.98693422 |
| 122 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.98386775 |
| 123 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.96907207 |
| 124 | negative regulation of DNA recombination (GO:0045910) | 2.96534320 |
| 125 | microtubule depolymerization (GO:0007019) | 2.96376718 |
| 126 | negative regulation of mitosis (GO:0045839) | 2.95373092 |
| 127 | synapsis (GO:0007129) | 2.92771103 |
| 128 | cullin deneddylation (GO:0010388) | 2.90947280 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 5.65620414 |
| 2 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.38242510 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.01615054 |
| 4 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.73842093 |
| 5 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.03461179 |
| 6 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.95697109 |
| 7 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.74116742 |
| 8 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.62772633 |
| 9 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.60528214 |
| 10 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.52001897 |
| 11 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.48573062 |
| 12 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.46929088 |
| 13 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.36740226 |
| 14 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.34578292 |
| 15 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.28119015 |
| 16 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.25501391 |
| 17 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.24278109 |
| 18 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.21948732 |
| 19 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.21149002 |
| 20 | * CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.15396531 |
| 21 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.11736950 |
| 22 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.09963504 |
| 23 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.09022341 |
| 24 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.00197711 |
| 25 | E2F7_22180533_ChIP-Seq_HELA_Human | 10.3913810 |
| 26 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.94571223 |
| 27 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.92466673 |
| 28 | * VDR_23849224_ChIP-Seq_CD4+_Human | 1.86608455 |
| 29 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.85397593 |
| 30 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.78769736 |
| 31 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.72730331 |
| 32 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.69259231 |
| 33 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.68622344 |
| 34 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.64923935 |
| 35 | * MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.62438410 |
| 36 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.59322839 |
| 37 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.58743822 |
| 38 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.58248430 |
| 39 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.54787734 |
| 40 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.51657925 |
| 41 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.51385025 |
| 42 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 1.51079273 |
| 43 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.50520584 |
| 44 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.44652302 |
| 45 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.44004864 |
| 46 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.43864772 |
| 47 | * EWS_26573619_Chip-Seq_HEK293_Human | 1.43484770 |
| 48 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.42560058 |
| 49 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.41990088 |
| 50 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.41551276 |
| 51 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.40932260 |
| 52 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.40389718 |
| 53 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.38005346 |
| 54 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.38005346 |
| 55 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.38005346 |
| 56 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.37780674 |
| 57 | FUS_26573619_Chip-Seq_HEK293_Human | 1.37333478 |
| 58 | * ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.36098132 |
| 59 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.34949267 |
| 60 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.33571844 |
| 61 | MYC_22102868_ChIP-Seq_BL_Human | 1.33337449 |
| 62 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.31577926 |
| 63 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.29860456 |
| 64 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.29824261 |
| 65 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.29533878 |
| 66 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.26958757 |
| 67 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.24343285 |
| 68 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.23014780 |
| 69 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.22277021 |
| 70 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.22098957 |
| 71 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.21729210 |
| 72 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.16468482 |
| 73 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.16372654 |
| 74 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.14764635 |
| 75 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.14040350 |
| 76 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.13522552 |
| 77 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.11971889 |
| 78 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.10810538 |
| 79 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.10004785 |
| 80 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.09132589 |
| 81 | * KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.08430057 |
| 82 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.04527322 |
| 83 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.04463696 |
| 84 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.03607514 |
| 85 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.03471260 |
| 86 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.03190368 |
| 87 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.02388980 |
| 88 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.02008720 |
| 89 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.01101806 |
| 90 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.00459116 |
| 91 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.97780770 |
| 92 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.97221891 |
| 93 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.96499193 |
| 94 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.96098726 |
| 95 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.96039627 |
| 96 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.94428016 |
| 97 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.94254190 |
| 98 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.93592496 |
| 99 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.91841634 |
| 100 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.87878532 |
| 101 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.87831613 |
| 102 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.87786521 |
| 103 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.87614149 |
| 104 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.86940259 |
| 105 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.84821004 |
| 106 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 0.82643004 |
| 107 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.81560231 |
| 108 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.79772506 |
| 109 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.79696886 |
| 110 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.76713462 |
| 111 | SOX2_18692474_ChIP-Seq_MESCs_Mouse | 0.76678591 |
| 112 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.76650765 |
| 113 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.75945145 |
| 114 | VDR_22108803_ChIP-Seq_LS180_Human | 0.75548411 |
| 115 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.74928838 |
| 116 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 0.74880600 |
| 117 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.74069532 |
| 118 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.72444775 |
| 119 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.72084590 |
| 120 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.71021876 |
| 121 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.69106177 |
| 122 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.66776152 |
| 123 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.63214630 |
| 124 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.62027398 |
| 125 | P300_19829295_ChIP-Seq_ESCs_Human | 0.60580240 |
| 126 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.60179986 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.35606599 |
| 2 | MP0010094_abnormal_chromosome_stability | 5.08184202 |
| 3 | MP0003111_abnormal_nucleus_morphology | 4.88980702 |
| 4 | MP0008057_abnormal_DNA_replication | 4.59759601 |
| 5 | MP0004957_abnormal_blastocyst_morpholog | 4.32689395 |
| 6 | MP0003077_abnormal_cell_cycle | 4.15914883 |
| 7 | MP0008058_abnormal_DNA_repair | 3.34809502 |
| 8 | MP0008007_abnormal_cellular_replicative | 2.76711223 |
| 9 | MP0008932_abnormal_embryonic_tissue | 2.70374129 |
| 10 | MP0001730_embryonic_growth_arrest | 2.50227490 |
| 11 | MP0003123_paternal_imprinting | 2.41698788 |
| 12 | MP0010307_abnormal_tumor_latency | 2.40242309 |
| 13 | MP0010352_gastrointestinal_tract_polyps | 2.38839435 |
| 14 | MP0000350_abnormal_cell_proliferation | 2.38794193 |
| 15 | MP0008877_abnormal_DNA_methylation | 2.36892055 |
| 16 | MP0009697_abnormal_copulation | 2.24703443 |
| 17 | MP0003786_premature_aging | 2.03971529 |
| 18 | MP0001672_abnormal_embryogenesis/_devel | 1.95756089 |
| 19 | MP0005380_embryogenesis_phenotype | 1.95756089 |
| 20 | MP0001529_abnormal_vocalization | 1.92731030 |
| 21 | MP0002396_abnormal_hematopoietic_system | 1.92228237 |
| 22 | MP0001697_abnormal_embryo_size | 1.86446669 |
| 23 | MP0002085_abnormal_embryonic_tissue | 1.76242603 |
| 24 | MP0002084_abnormal_developmental_patter | 1.73188143 |
| 25 | MP0003984_embryonic_growth_retardation | 1.72226068 |
| 26 | MP0004197_abnormal_fetal_growth/weight/ | 1.70105135 |
| 27 | MP0002088_abnormal_embryonic_growth/wei | 1.68795296 |
| 28 | MP0002080_prenatal_lethality | 1.64529950 |
| 29 | MP0002086_abnormal_extraembryonic_tissu | 1.58573173 |
| 30 | MP0003121_genomic_imprinting | 1.57406881 |
| 31 | MP0005076_abnormal_cell_differentiation | 1.55339912 |
| 32 | MP0003567_abnormal_fetal_cardiomyocyte | 1.53751011 |
| 33 | MP0000490_abnormal_crypts_of | 1.51826742 |
| 34 | MP0002210_abnormal_sex_determination | 1.47702021 |
| 35 | MP0003718_maternal_effect | 1.47071604 |
| 36 | MP0003890_abnormal_embryonic-extraembry | 1.44474782 |
| 37 | MP0001293_anophthalmia | 1.44239913 |
| 38 | MP0000313_abnormal_cell_death | 1.42740066 |
| 39 | MP0001188_hyperpigmentation | 1.32558047 |
| 40 | MP0006035_abnormal_mitochondrial_morpho | 1.30941094 |
| 41 | MP0002019_abnormal_tumor_incidence | 1.30672349 |
| 42 | MP0001145_abnormal_male_reproductive | 1.29108696 |
| 43 | MP0002938_white_spotting | 1.27645759 |
| 44 | MP0008789_abnormal_olfactory_epithelium | 1.26087455 |
| 45 | MP0003941_abnormal_skin_development | 1.23438140 |
| 46 | MP0004808_abnormal_hematopoietic_stem | 1.20298603 |
| 47 | MP0001929_abnormal_gametogenesis | 1.19723838 |
| 48 | MP0006072_abnormal_retinal_apoptosis | 1.19355958 |
| 49 | MP0003806_abnormal_nucleotide_metabolis | 1.19093505 |
| 50 | MP0000049_abnormal_middle_ear | 1.17586639 |
| 51 | MP0002233_abnormal_nose_morphology | 1.17063166 |
| 52 | MP0004133_heterotaxia | 1.16308352 |
| 53 | MP0010030_abnormal_orbit_morphology | 1.15841030 |
| 54 | MP0002234_abnormal_pharynx_morphology | 1.15476569 |
| 55 | MP0003119_abnormal_digestive_system | 1.10502774 |
| 56 | MP0000653_abnormal_sex_gland | 1.08644154 |
| 57 | MP0003705_abnormal_hypodermis_morpholog | 1.07999925 |
| 58 | MP0009053_abnormal_anal_canal | 1.07081298 |
| 59 | MP0003937_abnormal_limbs/digits/tail_de | 1.06552662 |
| 60 | MP0002751_abnormal_autonomic_nervous | 1.06136636 |
| 61 | MP0003315_abnormal_perineum_morphology | 1.02765722 |
| 62 | MP0005499_abnormal_olfactory_system | 1.00648061 |
| 63 | MP0005394_taste/olfaction_phenotype | 1.00648061 |
| 64 | MP0000537_abnormal_urethra_morphology | 0.96104398 |
| 65 | MP0002111_abnormal_tail_morphology | 0.95644845 |
| 66 | MP0003566_abnormal_cell_adhesion | 0.95000501 |
| 67 | MP0009672_abnormal_birth_weight | 0.92300016 |
| 68 | MP0009703_decreased_birth_body | 0.90541606 |
| 69 | MP0002653_abnormal_ependyma_morphology | 0.89956889 |
| 70 | MP0005397_hematopoietic_system_phenotyp | 0.89691752 |
| 71 | MP0001545_abnormal_hematopoietic_system | 0.89691752 |
| 72 | MP0000647_abnormal_sebaceous_gland | 0.88955548 |
| 73 | MP0001299_abnormal_eye_distance/ | 0.88656132 |
| 74 | MP0000579_abnormal_nail_morphology | 0.87445945 |
| 75 | MP0003186_abnormal_redox_activity | 0.85397903 |
| 76 | MP0001119_abnormal_female_reproductive | 0.84948626 |
| 77 | MP0000703_abnormal_thymus_morphology | 0.84877809 |
| 78 | MP0001286_abnormal_eye_development | 0.83113271 |
| 79 | MP0001915_intracranial_hemorrhage | 0.82302833 |
| 80 | MP0004264_abnormal_extraembryonic_tissu | 0.81996315 |
| 81 | MP0002697_abnormal_eye_size | 0.81044596 |
| 82 | MP0005384_cellular_phenotype | 0.80410984 |
| 83 | MP0005621_abnormal_cell_physiology | 0.79763690 |
| 84 | MP0003385_abnormal_body_wall | 0.79249316 |
| 85 | MP0002160_abnormal_reproductive_system | 0.78529805 |
| 86 | MP0005023_abnormal_wound_healing | 0.78348065 |
| 87 | MP0002092_abnormal_eye_morphology | 0.77754350 |
| 88 | MP0009333_abnormal_splenocyte_physiolog | 0.76461784 |
| 89 | MP0008995_early_reproductive_senescence | 0.74977058 |
| 90 | MP0005391_vision/eye_phenotype | 0.74652998 |
| 91 | MP0006292_abnormal_olfactory_placode | 0.74077758 |
| 92 | MP0001177_atelectasis | 0.73622834 |
| 93 | MP0000428_abnormal_craniofacial_morphol | 0.72611174 |
| 94 | MP0000372_irregular_coat_pigmentation | 0.72319173 |
| 95 | MP0000432_abnormal_head_morphology | 0.72099095 |
| 96 | MP0006036_abnormal_mitochondrial_physio | 0.71732977 |
| 97 | MP0003221_abnormal_cardiomyocyte_apopto | 0.70785556 |
| 98 | MP0000858_altered_metastatic_potential | 0.70770209 |
| 99 | MP0003136_yellow_coat_color | 0.70181550 |
| 100 | MP0006054_spinal_hemorrhage | 0.69787048 |
| 101 | MP0001346_abnormal_lacrimal_gland | 0.68755878 |
| 102 | MP0002177_abnormal_outer_ear | 0.68583716 |
| 103 | MP0005389_reproductive_system_phenotype | 0.68563543 |
| 104 | MP0002638_abnormal_pupillary_reflex | 0.68509609 |
| 105 | MP0002736_abnormal_nociception_after | 0.68493877 |
| 106 | MP0003698_abnormal_male_reproductive | 0.68449550 |
| 107 | MP0002722_abnormal_immune_system | 0.67967872 |
| 108 | MP0002081_perinatal_lethality | 0.67961889 |
| 109 | MP0009278_abnormal_bone_marrow | 0.66451637 |
| 110 | MP0003943_abnormal_hepatobiliary_system | 0.65474517 |
| 111 | MP0000358_abnormal_cell_content/ | 0.65028642 |
| 112 | MP0002398_abnormal_bone_marrow | 0.64940555 |
| 113 | MP0000631_abnormal_neuroendocrine_gland | 0.64663416 |
| 114 | MP0005395_other_phenotype | 0.64122907 |
| 115 | MP0002163_abnormal_gland_morphology | 0.63639236 |
| 116 | MP0003942_abnormal_urinary_system | 0.63533190 |
| 117 | MP0002282_abnormal_trachea_morphology | 0.62733104 |
| 118 | MP0001849_ear_inflammation | 0.62498186 |
| 119 | MP0003938_abnormal_ear_development | 0.62158945 |
| 120 | MP0002184_abnormal_innervation | 0.61055513 |
| 121 | MP0000689_abnormal_spleen_morphology | 0.61052903 |
| 122 | MP0002102_abnormal_ear_morphology | 0.60465867 |
| 123 | MP0003861_abnormal_nervous_system | 0.60367866 |
| 124 | MP0002925_abnormal_cardiovascular_devel | 0.59322726 |
| 125 | MP0003115_abnormal_respiratory_system | 0.59199938 |
| 126 | MP0003283_abnormal_digestive_organ | 0.58062533 |
| 127 | MP0000733_abnormal_muscle_development | 0.57978831 |
| 128 | MP0003787_abnormal_imprinting | 0.57637856 |
| 129 | MP0000477_abnormal_intestine_morphology | 0.57079401 |
| 130 | MP0002161_abnormal_fertility/fecundity | 0.56555636 |
| 131 | MP0003935_abnormal_craniofacial_develop | 0.54965662 |
| 132 | MP0003755_abnormal_palate_morphology | 0.54145119 |
| 133 | MP0003936_abnormal_reproductive_system | 0.54106774 |
| 134 | MP0003699_abnormal_female_reproductive | 0.52190472 |
| 135 | MP0003448_altered_tumor_morphology | 0.52142848 |
| 136 | MP0002114_abnormal_axial_skeleton | 0.51663018 |
| 137 | MP0003763_abnormal_thymus_physiology | 0.51545808 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Chromsome breakage (HP:0040012) | 5.11197947 |
| 2 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 4.90811288 |
| 3 | Birth length less than 3rd percentile (HP:0003561) | 4.49331147 |
| 4 | Abnormality of chromosome stability (HP:0003220) | 3.82125164 |
| 5 | Reticulocytopenia (HP:0001896) | 3.78904058 |
| 6 | Ependymoma (HP:0002888) | 3.78172582 |
| 7 | Breast hypoplasia (HP:0003187) | 3.68513362 |
| 8 | Medulloblastoma (HP:0002885) | 3.60397995 |
| 9 | Meckel diverticulum (HP:0002245) | 3.59762062 |
| 10 | Selective tooth agenesis (HP:0001592) | 3.48389548 |
| 11 | Colon cancer (HP:0003003) | 3.46343907 |
| 12 | Abnormality of the ileum (HP:0001549) | 3.42102048 |
| 13 | Abnormality of the preputium (HP:0100587) | 3.34830116 |
| 14 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.32799972 |
| 15 | Absent radius (HP:0003974) | 3.30091741 |
| 16 | Patellar aplasia (HP:0006443) | 3.26369413 |
| 17 | Abnormality of the labia minora (HP:0012880) | 3.20498860 |
| 18 | Impulsivity (HP:0100710) | 3.20033800 |
| 19 | Agnosia (HP:0010524) | 3.18431533 |
| 20 | Cortical dysplasia (HP:0002539) | 3.18306348 |
| 21 | Duodenal stenosis (HP:0100867) | 3.08814610 |
| 22 | Small intestinal stenosis (HP:0012848) | 3.08814610 |
| 23 | Absent forearm bone (HP:0003953) | 3.07841400 |
| 24 | Aplasia involving forearm bones (HP:0009822) | 3.07841400 |
| 25 | Ectopic kidney (HP:0000086) | 3.07672883 |
| 26 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.01656224 |
| 27 | Supernumerary spleens (HP:0009799) | 2.96073774 |
| 28 | Duplicated collecting system (HP:0000081) | 2.95295501 |
| 29 | Rhabdomyosarcoma (HP:0002859) | 2.93238884 |
| 30 | Oral leukoplakia (HP:0002745) | 2.84929366 |
| 31 | Absent thumb (HP:0009777) | 2.84924236 |
| 32 | Myelodysplasia (HP:0002863) | 2.79072993 |
| 33 | Carpal bone hypoplasia (HP:0001498) | 2.67959605 |
| 34 | Astrocytoma (HP:0009592) | 2.63691821 |
| 35 | Abnormality of the astrocytes (HP:0100707) | 2.63691821 |
| 36 | 11 pairs of ribs (HP:0000878) | 2.63219494 |
| 37 | Abnormality of the anterior horn cell (HP:0006802) | 2.60941436 |
| 38 | Degeneration of anterior horn cells (HP:0002398) | 2.60941436 |
| 39 | Increased nuchal translucency (HP:0010880) | 2.59690469 |
| 40 | Abnormality of the duodenum (HP:0002246) | 2.59501102 |
| 41 | Proximal placement of thumb (HP:0009623) | 2.58316590 |
| 42 | Volvulus (HP:0002580) | 2.57910488 |
| 43 | Sloping forehead (HP:0000340) | 2.55988663 |
| 44 | Abnormal number of incisors (HP:0011064) | 2.55893911 |
| 45 | Deviation of the thumb (HP:0009603) | 2.55671847 |
| 46 | Abnormality of the renal collecting system (HP:0004742) | 2.53349060 |
| 47 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.50117391 |
| 48 | Bone marrow hypocellularity (HP:0005528) | 2.48203991 |
| 49 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.47357438 |
| 50 | Neoplasm of the oral cavity (HP:0100649) | 2.47283445 |
| 51 | Abnormal lung lobation (HP:0002101) | 2.46909717 |
| 52 | Glioma (HP:0009733) | 2.44129834 |
| 53 | Missing ribs (HP:0000921) | 2.43779631 |
| 54 | Neoplasm of the pancreas (HP:0002894) | 2.39867631 |
| 55 | Abnormality of the carotid arteries (HP:0005344) | 2.35373821 |
| 56 | Tracheoesophageal fistula (HP:0002575) | 2.33997501 |
| 57 | Rough bone trabeculation (HP:0100670) | 2.31647247 |
| 58 | Abnormal number of erythroid precursors (HP:0012131) | 2.31446276 |
| 59 | Cafe-au-lait spot (HP:0000957) | 2.30555027 |
| 60 | Embryonal renal neoplasm (HP:0011794) | 2.30535932 |
| 61 | Abnormality of methionine metabolism (HP:0010901) | 2.30481250 |
| 62 | Basal cell carcinoma (HP:0002671) | 2.30098375 |
| 63 | Horseshoe kidney (HP:0000085) | 2.26378870 |
| 64 | Acute necrotizing encephalopathy (HP:0006965) | 2.26335716 |
| 65 | Atresia of the external auditory canal (HP:0000413) | 2.21480595 |
| 66 | Short thumb (HP:0009778) | 2.21327597 |
| 67 | Acute encephalopathy (HP:0006846) | 2.21138037 |
| 68 | Neoplasm of striated muscle (HP:0009728) | 2.21031684 |
| 69 | Biliary tract neoplasm (HP:0100574) | 2.20573349 |
| 70 | Multiple enchondromatosis (HP:0005701) | 2.19106533 |
| 71 | Premature graying of hair (HP:0002216) | 2.18620290 |
| 72 | Triphalangeal thumb (HP:0001199) | 2.17602484 |
| 73 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.17447389 |
| 74 | Increased serum pyruvate (HP:0003542) | 2.15549507 |
| 75 | Facial hemangioma (HP:0000329) | 2.12947930 |
| 76 | Prominent nose (HP:0000448) | 2.11326414 |
| 77 | Abnormality of DNA repair (HP:0003254) | 2.10029047 |
| 78 | Abnormality of glycolysis (HP:0004366) | 2.09778510 |
| 79 | Abnormality of abdominal situs (HP:0011620) | 2.09005353 |
| 80 | Abdominal situs inversus (HP:0003363) | 2.09005353 |
| 81 | Hypoplasia of the pons (HP:0012110) | 2.03760618 |
| 82 | Clubbing of toes (HP:0100760) | 2.02879580 |
| 83 | Aplastic anemia (HP:0001915) | 2.01488712 |
| 84 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.01271800 |
| 85 | High pitched voice (HP:0001620) | 1.99565061 |
| 86 | Microvesicular hepatic steatosis (HP:0001414) | 1.99169817 |
| 87 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.97832889 |
| 88 | Abnormality of the pons (HP:0007361) | 1.97503713 |
| 89 | Neoplasm of the colon (HP:0100273) | 1.97296570 |
| 90 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.96550691 |
| 91 | Squamous cell carcinoma (HP:0002860) | 1.96400921 |
| 92 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.95749133 |
| 93 | Abnormality of serum amino acid levels (HP:0003112) | 1.92065668 |
| 94 | Asplenia (HP:0001746) | 1.91863296 |
| 95 | Amaurosis fugax (HP:0100576) | 1.91283061 |
| 96 | Rib fusion (HP:0000902) | 1.90856885 |
| 97 | Megaloblastic anemia (HP:0001889) | 1.90547115 |
| 98 | Hypoplastic pelvis (HP:0008839) | 1.90029791 |
| 99 | Short humerus (HP:0005792) | 1.89477372 |
| 100 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.88251038 |
| 101 | Pallor (HP:0000980) | 1.87868882 |
| 102 | Ovarian neoplasm (HP:0100615) | 1.87306816 |
| 103 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.87044893 |
| 104 | Short 4th metacarpal (HP:0010044) | 1.87044893 |
| 105 | Homocystinuria (HP:0002156) | 1.86999610 |
| 106 | Abnormality of homocysteine metabolism (HP:0010919) | 1.86999610 |
| 107 | Ureteral duplication (HP:0000073) | 1.86854269 |
| 108 | Macrocytic anemia (HP:0001972) | 1.82829543 |
| 109 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.80628017 |
| 110 | Cellular immunodeficiency (HP:0005374) | 1.80170917 |
| 111 | Septo-optic dysplasia (HP:0100842) | 1.79428008 |
| 112 | Facial cleft (HP:0002006) | 1.78970982 |
| 113 | Arteriovenous malformation (HP:0100026) | 1.78353661 |
| 114 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.77608928 |
| 115 | Increased CSF lactate (HP:0002490) | 1.77258288 |
| 116 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.76553270 |
| 117 | Gastrointestinal carcinoma (HP:0002672) | 1.76553270 |
| 118 | Abnormality of the septum pellucidum (HP:0007375) | 1.75534125 |
| 119 | Increased hepatocellular lipid droplets (HP:0006565) | 1.74138534 |
| 120 | Supernumerary bones of the axial skeleton (HP:0009144) | 1.74117127 |
| 121 | Choanal atresia (HP:0000453) | 1.73885793 |
| 122 | Trismus (HP:0000211) | 1.73851289 |
| 123 | Absent septum pellucidum (HP:0001331) | 1.73384731 |
| 124 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.72879815 |
| 125 | Gonadotropin excess (HP:0000837) | 1.72628426 |
| 126 | Cerebral hypomyelination (HP:0006808) | 1.72380415 |
| 127 | Progressive macrocephaly (HP:0004481) | 1.69664822 |
| 128 | Hyperglycinemia (HP:0002154) | 1.69603000 |
| 129 | Stenosis of the external auditory canal (HP:0000402) | 1.69353619 |
| 130 | Cerebral edema (HP:0002181) | 1.68534159 |
| 131 | Bifid tongue (HP:0010297) | 1.67891224 |
| 132 | Preaxial hand polydactyly (HP:0001177) | 1.64507072 |
| 133 | Dandy-Walker malformation (HP:0001305) | 1.63948936 |
| 134 | Oligodactyly (hands) (HP:0001180) | 1.63898100 |
| 135 | Shoulder girdle muscle weakness (HP:0003547) | 1.63659810 |
| 136 | Small hand (HP:0200055) | 1.58643930 |
| 137 | Spastic diplegia (HP:0001264) | 1.56405258 |
| 138 | Progressive external ophthalmoplegia (HP:0000590) | 1.54943526 |
| 139 | Abnormality of cochlea (HP:0000375) | 1.54887799 |
| 140 | Increased serum lactate (HP:0002151) | 1.54794278 |
| 141 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.54187207 |
| 142 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.53313126 |
| 143 | Abnormality of alanine metabolism (HP:0010916) | 1.53313126 |
| 144 | Hyperalaninemia (HP:0003348) | 1.53313126 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDC7 | 4.93067055 |
| 2 | WEE1 | 4.55097292 |
| 3 | BUB1 | 4.17373011 |
| 4 | NEK2 | 3.32846602 |
| 5 | TTK | 3.05547708 |
| 6 | NEK1 | 2.97037460 |
| 7 | CDK12 | 2.68579017 |
| 8 | EIF2AK1 | 2.55185574 |
| 9 | SRPK1 | 2.54146861 |
| 10 | TRIM28 | 2.31366839 |
| 11 | PLK1 | 2.30400745 |
| 12 | BRSK2 | 2.24544706 |
| 13 | PLK4 | 2.15631621 |
| 14 | VRK2 | 2.10553768 |
| 15 | ACVR1B | 1.99150874 |
| 16 | ATR | 1.96611766 |
| 17 | AURKB | 1.91567170 |
| 18 | EPHA2 | 1.90098512 |
| 19 | TSSK6 | 1.88641615 |
| 20 | PLK3 | 1.81735152 |
| 21 | CDK7 | 1.81241787 |
| 22 | MKNK1 | 1.78407995 |
| 23 | CHEK2 | 1.78080170 |
| 24 | TAF1 | 1.69805466 |
| 25 | PASK | 1.67648247 |
| 26 | RPS6KB2 | 1.66119688 |
| 27 | WNK3 | 1.55284168 |
| 28 | CHEK1 | 1.52813506 |
| 29 | TLK1 | 1.50906659 |
| 30 | BCR | 1.47351975 |
| 31 | MAP3K8 | 1.47129665 |
| 32 | VRK1 | 1.47013985 |
| 33 | CDK4 | 1.46582418 |
| 34 | TNIK | 1.46283639 |
| 35 | STK10 | 1.44958093 |
| 36 | BRD4 | 1.44701629 |
| 37 | MKNK2 | 1.38706929 |
| 38 | STK4 | 1.38545512 |
| 39 | BRSK1 | 1.35057445 |
| 40 | DYRK3 | 1.33373900 |
| 41 | AURKA | 1.33240276 |
| 42 | SCYL2 | 1.25836747 |
| 43 | ZAK | 1.23093774 |
| 44 | EEF2K | 1.22756809 |
| 45 | PNCK | 1.21421544 |
| 46 | CCNB1 | 1.20789868 |
| 47 | TESK2 | 1.20265270 |
| 48 | BMPR1B | 1.19645382 |
| 49 | EIF2AK3 | 1.18073840 |
| 50 | RPS6KA4 | 1.17552528 |
| 51 | ATM | 1.16532682 |
| 52 | NME2 | 1.16343854 |
| 53 | NME1 | 1.12624210 |
| 54 | NUAK1 | 1.05218745 |
| 55 | CDK2 | 1.01338842 |
| 56 | STK16 | 0.97197150 |
| 57 | CDK6 | 0.95644565 |
| 58 | PAK4 | 0.95289920 |
| 59 | PLK2 | 0.90834384 |
| 60 | MELK | 0.89273317 |
| 61 | ERBB4 | 0.86172283 |
| 62 | STK3 | 0.84465263 |
| 63 | ALK | 0.83775314 |
| 64 | DYRK2 | 0.83292680 |
| 65 | ERBB3 | 0.82576247 |
| 66 | CDK1 | 0.81329124 |
| 67 | PIM1 | 0.80605856 |
| 68 | TGFBR1 | 0.79240983 |
| 69 | FLT3 | 0.78172592 |
| 70 | MAP3K4 | 0.73332168 |
| 71 | CSNK1G1 | 0.71992268 |
| 72 | PKN2 | 0.70459265 |
| 73 | MAP3K10 | 0.67847138 |
| 74 | CASK | 0.65306409 |
| 75 | STK38L | 0.65203270 |
| 76 | AKT3 | 0.64747899 |
| 77 | CSNK2A2 | 0.64158728 |
| 78 | CLK1 | 0.64117534 |
| 79 | EIF2AK2 | 0.62905279 |
| 80 | CSNK1G3 | 0.61751331 |
| 81 | PAK1 | 0.60355710 |
| 82 | CSNK2A1 | 0.59358356 |
| 83 | PRKCI | 0.57396328 |
| 84 | MINK1 | 0.56793353 |
| 85 | MAP2K7 | 0.56748400 |
| 86 | PBK | 0.56370793 |
| 87 | CSNK1G2 | 0.55778042 |
| 88 | LATS1 | 0.55097421 |
| 89 | MTOR | 0.54348556 |
| 90 | BRAF | 0.53958521 |
| 91 | PDK4 | 0.53535009 |
| 92 | PDK3 | 0.53535009 |
| 93 | CDK19 | 0.51549921 |
| 94 | TESK1 | 0.48878621 |
| 95 | PRKDC | 0.48302618 |
| 96 | CDK18 | 0.46665760 |
| 97 | CSNK1D | 0.45386028 |
| 98 | CDK14 | 0.45101157 |
| 99 | LATS2 | 0.43806602 |
| 100 | CSNK1A1L | 0.43056555 |
| 101 | CSNK1E | 0.41654299 |
| 102 | RPS6KA5 | 0.41094784 |
| 103 | CDK3 | 0.39749919 |
| 104 | AKT2 | 0.39582798 |
| 105 | LRRK2 | 0.36903128 |
| 106 | EPHA4 | 0.36318364 |
| 107 | MAP4K2 | 0.35741099 |
| 108 | MAPK14 | 0.35053728 |
| 109 | CDK8 | 0.31878819 |
| 110 | MARK3 | 0.31353845 |
| 111 | MAP3K9 | 0.31273336 |
| 112 | YES1 | 0.30360803 |
| 113 | AKT1 | 0.28769881 |
| 114 | OXSR1 | 0.27495391 |
| 115 | SIK3 | 0.26420026 |
| 116 | PAK2 | 0.26023924 |
| 117 | GSK3B | 0.25721625 |
| 118 | MAPK1 | 0.25660502 |
| 119 | KSR1 | 0.25438507 |
| 120 | STK39 | 0.25188829 |
| 121 | PDK2 | 0.24314385 |
| 122 | FGFR1 | 0.24231677 |
| 123 | MET | 0.22756094 |
| 124 | MAPKAPK3 | 0.21798021 |
| 125 | MAP2K3 | 0.21340478 |
| 126 | CDK9 | 0.19480254 |
| 127 | TTN | 0.16643726 |
| 128 | RPS6KB1 | 0.16075900 |
| 129 | CDK11A | 0.15485010 |
| 130 | MST4 | 0.13258084 |
| 131 | TAOK2 | 0.13092445 |
| 132 | CDK15 | 0.12758560 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 5.11013085 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.50754906 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.63977172 |
| 4 | Homologous recombination_Homo sapiens_hsa03440 | 3.43263113 |
| 5 | RNA transport_Homo sapiens_hsa03013 | 3.31061396 |
| 6 | Spliceosome_Homo sapiens_hsa03040 | 3.23120241 |
| 7 | Cell cycle_Homo sapiens_hsa04110 | 3.18959898 |
| 8 | Base excision repair_Homo sapiens_hsa03410 | 3.05654332 |
| 9 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.98018335 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.97333091 |
| 11 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.92718584 |
| 12 | RNA polymerase_Homo sapiens_hsa03020 | 2.76799510 |
| 13 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.71078040 |
| 14 | Ribosome_Homo sapiens_hsa03010 | 2.51440690 |
| 15 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.43963266 |
| 16 | Proteasome_Homo sapiens_hsa03050 | 2.34371894 |
| 17 | Protein export_Homo sapiens_hsa03060 | 2.23435805 |
| 18 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.17829400 |
| 19 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.00226505 |
| 20 | Basal transcription factors_Homo sapiens_hsa03022 | 1.98216100 |
| 21 | RNA degradation_Homo sapiens_hsa03018 | 1.95936870 |
| 22 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.86137505 |
| 23 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.62460465 |
| 24 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.54854933 |
| 25 | Parkinsons disease_Homo sapiens_hsa05012 | 1.46793392 |
| 26 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.44215268 |
| 27 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.42702336 |
| 28 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.40420647 |
| 29 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.39428969 |
| 30 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.27698074 |
| 31 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.27129467 |
| 32 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.25327124 |
| 33 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.24882434 |
| 34 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.23269409 |
| 35 | Purine metabolism_Homo sapiens_hsa00230 | 1.16640208 |
| 36 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.15489027 |
| 37 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.12608078 |
| 38 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.11996887 |
| 39 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.10777483 |
| 40 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.92996874 |
| 41 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.92861502 |
| 42 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.91942745 |
| 43 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.87468297 |
| 44 | HTLV-I infection_Homo sapiens_hsa05166 | 0.85635695 |
| 45 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.83171266 |
| 46 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.76715422 |
| 47 | Alzheimers disease_Homo sapiens_hsa05010 | 0.76307124 |
| 48 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.75876113 |
| 49 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.74612012 |
| 50 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.74067693 |
| 51 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.71284397 |
| 52 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.69839568 |
| 53 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.67390929 |
| 54 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.63942696 |
| 55 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.62494883 |
| 56 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.61706587 |
| 57 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.61064045 |
| 58 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.60765167 |
| 59 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.59006085 |
| 60 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.59005837 |
| 61 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.58612448 |
| 62 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.57166504 |
| 63 | Thyroid cancer_Homo sapiens_hsa05216 | 0.56780280 |
| 64 | Alcoholism_Homo sapiens_hsa05034 | 0.53303135 |
| 65 | Metabolic pathways_Homo sapiens_hsa01100 | 0.52320345 |
| 66 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.48882020 |
| 67 | Legionellosis_Homo sapiens_hsa05134 | 0.46960592 |
| 68 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.46300620 |
| 69 | Colorectal cancer_Homo sapiens_hsa05210 | 0.43473290 |
| 70 | Sulfur relay system_Homo sapiens_hsa04122 | 0.43462282 |
| 71 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.43420226 |
| 72 | Apoptosis_Homo sapiens_hsa04210 | 0.43195643 |
| 73 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.41742821 |
| 74 | Adherens junction_Homo sapiens_hsa04520 | 0.39935947 |
| 75 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.39799355 |
| 76 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.39575156 |
| 77 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.38880858 |
| 78 | Bladder cancer_Homo sapiens_hsa05219 | 0.37686749 |
| 79 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.35988250 |
| 80 | Hepatitis B_Homo sapiens_hsa05161 | 0.35285928 |
| 81 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.35277599 |
| 82 | Lysine degradation_Homo sapiens_hsa00310 | 0.35230574 |
| 83 | Phototransduction_Homo sapiens_hsa04744 | 0.34296997 |
| 84 | Carbon metabolism_Homo sapiens_hsa01200 | 0.33535110 |
| 85 | Pathways in cancer_Homo sapiens_hsa05200 | 0.33019398 |
| 86 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.32815140 |
| 87 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.32464958 |
| 88 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.31900837 |
| 89 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.31611894 |
| 90 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.30897290 |
| 91 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.30069291 |
| 92 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.29833085 |
| 93 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.29446318 |
| 94 | Prostate cancer_Homo sapiens_hsa05215 | 0.29156473 |
| 95 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.29080752 |
| 96 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.28456762 |
| 97 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.28330392 |
| 98 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.27518037 |
| 99 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.27365879 |
| 100 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.26111908 |
| 101 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.25186588 |
| 102 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.24913790 |
| 103 | Shigellosis_Homo sapiens_hsa05131 | 0.24645754 |
| 104 | Tight junction_Homo sapiens_hsa04530 | 0.24617520 |
| 105 | Measles_Homo sapiens_hsa05162 | 0.24531975 |
| 106 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.22767228 |
| 107 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.22599649 |
| 108 | Influenza A_Homo sapiens_hsa05164 | 0.21863015 |
| 109 | Melanoma_Homo sapiens_hsa05218 | 0.20318235 |
| 110 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.19392152 |
| 111 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.18256590 |
| 112 | Viral myocarditis_Homo sapiens_hsa05416 | 0.18245004 |
| 113 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.18059961 |
| 114 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.17641479 |
| 115 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.15346175 |
| 116 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.15013602 |
| 117 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.14893989 |
| 118 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.14811254 |
| 119 | Huntingtons disease_Homo sapiens_hsa05016 | 0.14387257 |
| 120 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.13202338 |
| 121 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.12650962 |
| 122 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.12465426 |
| 123 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.11876610 |
| 124 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.10013695 |
| 125 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.09795758 |
| 126 | Galactose metabolism_Homo sapiens_hsa00052 | 0.09373231 |
| 127 | Nicotine addiction_Homo sapiens_hsa05033 | 0.09241029 |
| 128 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.08644020 |
| 129 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.08204369 |
| 130 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.08169719 |
| 131 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.07955271 |
| 132 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.07918744 |
| 133 | Peroxisome_Homo sapiens_hsa04146 | 0.07351276 |
| 134 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.03844871 |

