ZWINT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)6.59258518
2DNA unwinding involved in DNA replication (GO:0006268)6.54914290
3DNA strand elongation (GO:0022616)6.35094447
4telomere maintenance via semi-conservative replication (GO:0032201)5.89406906
5synaptic vesicle exocytosis (GO:0016079)5.82186189
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.74131739
7vocalization behavior (GO:0071625)5.39932723
8neuron cell-cell adhesion (GO:0007158)5.31861284
9* mitotic sister chromatid segregation (GO:0000070)5.29431184
10mitotic chromosome condensation (GO:0007076)5.23511336
11glutamate secretion (GO:0014047)5.20594512
12CENP-A containing nucleosome assembly (GO:0034080)5.14626166
13chromatin remodeling at centromere (GO:0031055)5.13276047
14regulation of synaptic vesicle exocytosis (GO:2000300)5.10396270
15DNA replication checkpoint (GO:0000076)5.07666915
16protein localization to kinetochore (GO:0034501)5.05848856
17establishment of integrated proviral latency (GO:0075713)5.03528408
18telomere maintenance via recombination (GO:0000722)5.00885364
19DNA replication initiation (GO:0006270)5.00746255
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.99858196
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.98257094
22* sister chromatid segregation (GO:0000819)4.88424685
23mitotic recombination (GO:0006312)4.86346163
24synaptic vesicle docking involved in exocytosis (GO:0016081)4.85172722
25mitotic metaphase plate congression (GO:0007080)4.84955305
26neurotransmitter secretion (GO:0007269)4.82016298
27regulation of glutamate receptor signaling pathway (GO:1900449)4.81003071
28protein localization to chromosome, centromeric region (GO:0071459)4.73868543
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.64181720
30synaptic vesicle maturation (GO:0016188)4.63126519
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.50750705
32protein localization to synapse (GO:0035418)4.49984273
33regulation of synaptic vesicle transport (GO:1902803)4.47319408
34locomotory exploration behavior (GO:0035641)4.33728710
35nucleotide-excision repair, DNA gap filling (GO:0006297)4.32637956
36DNA ligation (GO:0006266)4.30343671
37neuronal action potential propagation (GO:0019227)4.28539849
38kinetochore organization (GO:0051383)4.27474975
39negative regulation of synaptic transmission, GABAergic (GO:0032229)4.22021993
40neuron-neuron synaptic transmission (GO:0007270)4.20311067
41DNA replication-independent nucleosome assembly (GO:0006336)4.20018314
42DNA replication-independent nucleosome organization (GO:0034724)4.20018314
43metaphase plate congression (GO:0051310)4.18275435
44neurotransmitter-gated ion channel clustering (GO:0072578)4.18070064
45histone exchange (GO:0043486)4.12996651
46regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.12476722
47ATP hydrolysis coupled proton transport (GO:0015991)4.11881747
48energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.11881747
49ionotropic glutamate receptor signaling pathway (GO:0035235)4.09168156
50establishment of viral latency (GO:0019043)4.01001228
51neurotransmitter transport (GO:0006836)4.00310111
52gamma-aminobutyric acid signaling pathway (GO:0007214)3.96841888
53regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.96404251
54transferrin transport (GO:0033572)3.96075860
55telomere maintenance via telomere lengthening (GO:0010833)3.94505622
56gamma-aminobutyric acid transport (GO:0015812)3.94461644
57presynaptic membrane assembly (GO:0097105)3.93913493
58synaptic transmission, glutamatergic (GO:0035249)3.91421330
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.88700910
60proline transport (GO:0015824)3.87136566
61DNA topological change (GO:0006265)3.86707013
62response to histamine (GO:0034776)3.85568005
63positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.85383503
64nuclear pore complex assembly (GO:0051292)3.81211597
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.81151558
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.79794999
67mitotic nuclear envelope disassembly (GO:0007077)3.78308903
68regulation of neurotransmitter levels (GO:0001505)3.77440656
69postsynaptic membrane organization (GO:0001941)3.74656273
70glutamate receptor signaling pathway (GO:0007215)3.71708387
71exploration behavior (GO:0035640)3.71225131
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.70861775
73purine nucleobase biosynthetic process (GO:0009113)3.69099389
74ferric iron transport (GO:0015682)3.68822319
75trivalent inorganic cation transport (GO:0072512)3.68822319
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.66960711
77kinetochore assembly (GO:0051382)3.65228344
78presynaptic membrane organization (GO:0097090)3.65014663
79positive regulation of synaptic transmission, GABAergic (GO:0032230)3.64834038
80regulation of long-term neuronal synaptic plasticity (GO:0048169)3.62587767
81spindle checkpoint (GO:0031577)3.60471201
82establishment of chromosome localization (GO:0051303)3.58793043
83regulation of neuronal synaptic plasticity (GO:0048168)3.57509149
84negative regulation of chromosome segregation (GO:0051985)3.56512828
85proteasome assembly (GO:0043248)3.56065195
86positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.55506415
87regulation of chromosome segregation (GO:0051983)3.55446568
88negative regulation of ligase activity (GO:0051352)3.54771624
89negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.54771624
90positive regulation of neurotransmitter transport (GO:0051590)3.52557814
91DNA replication-dependent nucleosome assembly (GO:0006335)3.52136456
92DNA replication-dependent nucleosome organization (GO:0034723)3.52136456
93chromosome condensation (GO:0030261)3.51850769
94nucleobase biosynthetic process (GO:0046112)3.51081846
95long-term synaptic potentiation (GO:0060291)3.50474603
96membrane disassembly (GO:0030397)3.49327213
97nuclear envelope disassembly (GO:0051081)3.49327213
98deoxyribonucleotide biosynthetic process (GO:0009263)3.49318271
99nuclear pore organization (GO:0006999)3.48862586
100regulation of synapse structural plasticity (GO:0051823)3.47916849
101negative regulation of mitotic sister chromatid separation (GO:2000816)3.47846098
102negative regulation of sister chromatid segregation (GO:0033046)3.47846098
103negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.47846098
104negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.47846098
105negative regulation of mitotic sister chromatid segregation (GO:0033048)3.47846098
106regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.47176220
107non-recombinational repair (GO:0000726)3.46794078
108double-strand break repair via nonhomologous end joining (GO:0006303)3.46794078
109regulation of excitatory postsynaptic membrane potential (GO:0060079)3.46739127
110negative regulation of dendrite morphogenesis (GO:0050774)3.46714683
111IMP biosynthetic process (GO:0006188)3.46354415
112* chromosome segregation (GO:0007059)3.44019995
113neuromuscular process controlling posture (GO:0050884)3.43587598
114neuron recognition (GO:0008038)3.43514335
115mitotic sister chromatid cohesion (GO:0007064)3.43435317
116negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.42602997
117regulation of spindle organization (GO:0090224)3.42474354
118mitotic spindle checkpoint (GO:0071174)3.42388496
119regulation of protein kinase A signaling (GO:0010738)3.41109319
120positive regulation of synapse assembly (GO:0051965)3.40905120
121regulation of synaptic transmission, glutamatergic (GO:0051966)3.40395116
122regulation of glutamate secretion (GO:0014048)3.39939920
123regulation of neurotransmitter secretion (GO:0046928)3.39271259
124G1/S transition of mitotic cell cycle (GO:0000082)3.38728491
125cell cycle G1/S phase transition (GO:0044843)3.38728491
126chromatin assembly or disassembly (GO:0006333)3.37720503
127formation of translation preinitiation complex (GO:0001731)3.37659709
128regulation of postsynaptic membrane potential (GO:0060078)3.36911264
129activation of protein kinase A activity (GO:0034199)3.36789076
130mitotic spindle assembly checkpoint (GO:0007094)3.35691203
131regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.35642799
132regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.35642799
133spindle assembly checkpoint (GO:0071173)3.33651060
134startle response (GO:0001964)3.33403314
135synaptic vesicle endocytosis (GO:0048488)3.32280290
136behavioral response to cocaine (GO:0048148)3.31971172
137regulation of neurotransmitter transport (GO:0051588)3.30764973
138striatum development (GO:0021756)3.30639853
139regulation of double-strand break repair via homologous recombination (GO:0010569)3.30519933
140regulation of mitotic metaphase/anaphase transition (GO:0030071)3.30151292
141regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.30151292
142regulation of centriole replication (GO:0046599)3.29396407
143ribosome assembly (GO:0042255)3.28523225
144positive regulation of synapse maturation (GO:0090129)3.28110401
145nucleobase-containing small molecule interconversion (GO:0015949)3.27798754
146protein localization to chromosome (GO:0034502)3.27182542
147positive regulation of membrane potential (GO:0045838)3.27060347
148positive regulation of chromosome segregation (GO:0051984)3.26781646
149regulation of mitotic spindle organization (GO:0060236)3.26127637
150female mating behavior (GO:0060180)3.24565708
151ATP-dependent chromatin remodeling (GO:0043044)3.24487129
152folic acid-containing compound biosynthetic process (GO:0009396)3.23981732
153regulation of synaptic transmission, GABAergic (GO:0032228)3.23969180
154deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.23601229
155DNA catabolic process, exonucleolytic (GO:0000738)3.23561293
156* mitotic cell cycle (GO:0000278)3.21902321
157transcription-coupled nucleotide-excision repair (GO:0006283)3.21385777
158regulation of mitotic sister chromatid separation (GO:0010965)3.19562169
159regulation of mitotic sister chromatid segregation (GO:0033047)3.19562169
160regulation of sister chromatid segregation (GO:0033045)3.19562169
161synaptic transmission, dopaminergic (GO:0001963)3.19260662
162transmission of nerve impulse (GO:0019226)3.19204201
163long-term memory (GO:0007616)3.17453029
164DNA packaging (GO:0006323)3.16357641
165heterochromatin organization (GO:0070828)3.15836157
166base-excision repair (GO:0006284)3.14784058
167synaptic transmission (GO:0007268)3.14252123
168positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.13438717
169spliceosomal snRNP assembly (GO:0000387)3.12904457
170cerebellar Purkinje cell differentiation (GO:0021702)3.12049128
171regulation of female receptivity (GO:0045924)3.11394317
172regulation of vesicle fusion (GO:0031338)3.11141398
173telomere maintenance (GO:0000723)3.10794476
174telomere organization (GO:0032200)3.10743303
175negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.10729380
176maturation of SSU-rRNA (GO:0030490)3.09694545
177positive regulation of synaptic transmission (GO:0050806)3.09611521
178regulation of synaptic transmission, dopaminergic (GO:0032225)3.09545311
179regulation of synaptic plasticity (GO:0048167)3.09173363
180DNA duplex unwinding (GO:0032508)3.09086751
181positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.08644174
182establishment of synaptic vesicle localization (GO:0097480)3.08524023
183synaptic vesicle transport (GO:0048489)3.08524023
184attachment of spindle microtubules to kinetochore (GO:0008608)3.07593256
185regulation of mitochondrial translation (GO:0070129)3.07197976
186synapse assembly (GO:0007416)3.06433492
187positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.03906497
188membrane hyperpolarization (GO:0060081)3.02494580
189auditory behavior (GO:0031223)3.02364434
190behavioral defense response (GO:0002209)3.01938482
191behavioral fear response (GO:0001662)3.01938482
192membrane depolarization (GO:0051899)2.98774116
193mechanosensory behavior (GO:0007638)2.97779912
194layer formation in cerebral cortex (GO:0021819)2.95627083
195mating behavior (GO:0007617)2.95496138
196regulation of neurotransmitter uptake (GO:0051580)2.95474850
197neurotransmitter uptake (GO:0001504)2.94269971
198positive regulation of neurotransmitter secretion (GO:0001956)2.94026932
199cerebellar granule cell differentiation (GO:0021707)2.93336863
200regulation of synaptic transmission (GO:0050804)2.92266189

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.79765241
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.18618876
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.60920955
4GBX2_23144817_ChIP-Seq_PC3_Human4.40561844
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.14526338
6MYC_18555785_ChIP-Seq_MESCs_Mouse4.09909114
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.99884957
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49597028
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.23873889
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18210373
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.10516780
12TAF15_26573619_Chip-Seq_HEK293_Human3.03686444
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00805885
14* AR_21909140_ChIP-Seq_LNCAP_Human2.99016870
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.91768021
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88844446
17REST_21632747_ChIP-Seq_MESCs_Mouse2.85538484
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83414323
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82830181
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80038665
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.77621434
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75576179
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60116961
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.58771398
25* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50272899
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49906838
27* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.48870805
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.48814431
29ETS1_20019798_ChIP-Seq_JURKAT_Human2.47443305
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46147868
31JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45704682
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45326415
33EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44714719
34RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44714719
35REST_18959480_ChIP-ChIP_MESCs_Mouse2.42244697
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.42100437
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.38787754
38* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.38196282
39* EZH2_27304074_Chip-Seq_ESCs_Mouse2.37880380
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33705287
41NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33009455
42MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29340661
43EED_16625203_ChIP-ChIP_MESCs_Mouse2.26134760
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.23142272
45RARB_27405468_Chip-Seq_BRAIN_Mouse2.23046555
46XRN2_22483619_ChIP-Seq_HELA_Human2.22384598
47DCP1A_22483619_ChIP-Seq_HELA_Human2.18285051
48THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16475289
49E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11163074
50* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08995304
51ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06908333
52IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06394875
53E2F7_22180533_ChIP-Seq_HELA_Human10.7302160
54TTF2_22483619_ChIP-Seq_HELA_Human1.99197407
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98660743
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95051194
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94980719
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94027728
59SMAD4_21799915_ChIP-Seq_A2780_Human1.93820802
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.92044380
61DROSHA_22980978_ChIP-Seq_HELA_Human1.90608403
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88989069
63* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.86729854
64FOXP3_21729870_ChIP-Seq_TREG_Human1.86522830
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84568127
66* RNF2_27304074_Chip-Seq_ESCs_Mouse1.83782709
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82837073
68ELK1_19687146_ChIP-ChIP_HELA_Human1.82379421
69* P300_19829295_ChIP-Seq_ESCs_Human1.80623416
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77245076
71* GABP_19822575_ChIP-Seq_HepG2_Human1.76054095
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75536845
73VDR_23849224_ChIP-Seq_CD4+_Human1.74139678
74ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72260763
75AR_21572438_ChIP-Seq_LNCaP_Human1.71800513
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70888136
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70231172
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70110833
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.66702879
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65079249
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63767270
82* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62167309
83* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61114470
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60610487
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59435907
86NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56478547
87FUS_26573619_Chip-Seq_HEK293_Human1.55354781
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54364796
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53623841
90ZNF274_21170338_ChIP-Seq_K562_Hela1.51413894
91IGF1R_20145208_ChIP-Seq_DFB_Human1.51039956
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50466651
93* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50094154
94* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47046855
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.46845322
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.45557155
97SRF_21415370_ChIP-Seq_HL-1_Mouse1.44511810
98* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43904354
99YY1_21170310_ChIP-Seq_MESCs_Mouse1.42966848
100* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.42882743
101* RNF2_27304074_Chip-Seq_NSC_Mouse1.42187145
102* SOX2_21211035_ChIP-Seq_LN229_Gbm1.41320042
103* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40993791
104PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40771292
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40277941
106NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40114953
107* KDM5A_27292631_Chip-Seq_BREAST_Human1.39753925
108* AR_25329375_ChIP-Seq_VCAP_Human1.38115120
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.38092047
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36957680
111VDR_22108803_ChIP-Seq_LS180_Human1.35908100
112ERG_21242973_ChIP-ChIP_JURKAT_Human1.32338831
113PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30560512
114SMAD_19615063_ChIP-ChIP_OVARY_Human1.29785312
115ER_23166858_ChIP-Seq_MCF-7_Human1.28484372
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24720485
117* STAT3_23295773_ChIP-Seq_U87_Human1.23435772
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22199588
119JUN_21703547_ChIP-Seq_K562_Human1.21927923
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21904306
121* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19743568
122SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17873690
123* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17634504
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17218788
125* TCF4_23295773_ChIP-Seq_U87_Human1.15286819
126CIITA_25753668_ChIP-Seq_RAJI_Human1.14536615
127RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14510387
128ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13242219
129CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12671639
130TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12417179
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11203868
132MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10945897
133* RUNX2_22187159_ChIP-Seq_PCA_Human1.10470894
134* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10055278
135MYC_18940864_ChIP-ChIP_HL60_Human1.09770581
136FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09123899
137PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09003476
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08506934
139KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07804079
140MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07325979
141PRDM14_20953172_ChIP-Seq_ESCs_Human1.05469125
142* AR_19668381_ChIP-Seq_PC3_Human1.04688177
143CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03561201
144P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03399540
145ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03175300
146RING1B_27294783_Chip-Seq_ESCs_Mouse1.01649639
147DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00242095
148KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99097981
149SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98925211
150NANOG_18555785_Chip-Seq_ESCs_Mouse0.97124673
151* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95620843
152YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95532424
153CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94847642
154CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94798699
155POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94643677
156CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94385732
157EGR1_19374776_ChIP-ChIP_THP-1_Human0.94347068
158EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93980691
159TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93680807
160SOX17_20123909_ChIP-Seq_XEN_Mouse0.93505098
161BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93269356
162* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92369301
163RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92228978
164* ARNT_22903824_ChIP-Seq_MCF-7_Human0.92060866
165* SOX9_26525672_Chip-Seq_HEART_Mouse0.91599326
166SMAD3_21741376_ChIP-Seq_ESCs_Human0.91267928
167CBP_20019798_ChIP-Seq_JUKART_Human0.91128593
168IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91128593
169PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89732936
170* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89310969
171CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86528214
172BCAT_22108803_ChIP-Seq_LS180_Human0.84841756
173* EWS_26573619_Chip-Seq_HEK293_Human0.84456526
174SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84101396
175* KDM2B_26808549_Chip-Seq_REH_Human0.83955796
176ZNF263_19887448_ChIP-Seq_K562_Human0.83885646
177STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83688622
178CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83407217
179NANOG_16153702_ChIP-ChIP_HESCs_Human0.82988656
180FLI1_27457419_Chip-Seq_LIVER_Mouse0.82828041
181TP53_18474530_ChIP-ChIP_U2OS_Human0.82738060
182HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82199917
183TFEB_21752829_ChIP-Seq_HELA_Human0.81908920
184* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81879572
185MYC_22102868_ChIP-Seq_BL_Human0.81120283
186HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80295045
187TP63_19390658_ChIP-ChIP_HaCaT_Human0.78181562
188* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.77774102
189ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.77209425
190* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76638937
191CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76162930
192DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74954561
193TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.74269399
194SOX2_16153702_ChIP-ChIP_HESCs_Human0.72950442
195TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.72579228
196TBX5_21415370_ChIP-Seq_HL-1_Mouse0.72049141
197NANOG_21062744_ChIP-ChIP_HESCs_Human0.70872614
198RBPJ_22232070_ChIP-Seq_NCS_Mouse0.69282779
199CHD1_26751641_Chip-Seq_LNCaP_Human0.68527438
200SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.66854199

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability6.42982851
2MP0003111_abnormal_nucleus_morphology5.41881936
3MP0003693_abnormal_embryo_hatching5.37330052
4MP0003880_abnormal_central_pattern5.09895170
5MP0004859_abnormal_synaptic_plasticity4.97075197
6MP0004957_abnormal_blastocyst_morpholog4.63586527
7MP0008058_abnormal_DNA_repair4.39476999
8MP0008057_abnormal_DNA_replication4.37837922
9MP0003077_abnormal_cell_cycle4.37756725
10MP0003635_abnormal_synaptic_transmissio3.83403214
11MP0009046_muscle_twitch3.57108556
12MP0008932_abnormal_embryonic_tissue3.54434207
13MP0009745_abnormal_behavioral_response3.45194706
14MP0001968_abnormal_touch/_nociception3.33871840
15MP0002064_seizures3.32546162
16MP0008007_abnormal_cellular_replicative3.11577174
17MP0002063_abnormal_learning/memory/cond3.08476156
18MP0002822_catalepsy2.93279343
19MP0002736_abnormal_nociception_after2.93237073
20MP0004270_analgesia2.86446682
21MP0002572_abnormal_emotion/affect_behav2.86224203
22MP0003122_maternal_imprinting2.72191620
23MP0006276_abnormal_autonomic_nervous2.70564712
24MP0002272_abnormal_nervous_system2.64076323
25MP0002734_abnormal_mechanical_nocicepti2.55980991
26MP0001501_abnormal_sleep_pattern2.49408142
27MP0001529_abnormal_vocalization2.48777962
28MP0002735_abnormal_chemical_nociception2.47626166
29MP0005423_abnormal_somatic_nervous2.38969919
30MP0003786_premature_aging2.37511829
31MP0001440_abnormal_grooming_behavior2.37191297
32MP0009697_abnormal_copulation2.31533746
33MP0001486_abnormal_startle_reflex2.29479762
34MP0000350_abnormal_cell_proliferation2.28944329
35MP0003787_abnormal_imprinting2.14996242
36MP0001730_embryonic_growth_arrest2.13939655
37MP0005646_abnormal_pituitary_gland2.13866298
38MP0002067_abnormal_sensory_capabilities2.10860761
39MP0002733_abnormal_thermal_nociception2.10314710
40MP0001970_abnormal_pain_threshold2.04974323
41MP0003718_maternal_effect2.01256914
42MP0003806_abnormal_nucleotide_metabolis1.92806558
43MP0005386_behavior/neurological_phenoty1.91803682
44MP0004924_abnormal_behavior1.91803682
45MP0001905_abnormal_dopamine_level1.91085023
46MP0005645_abnormal_hypothalamus_physiol1.79939618
47MP0010307_abnormal_tumor_latency1.79110853
48MP0009780_abnormal_chondrocyte_physiolo1.78399756
49MP0001697_abnormal_embryo_size1.74363285
50MP0002557_abnormal_social/conspecific_i1.73757295
51MP0002184_abnormal_innervation1.72855623
52MP0004142_abnormal_muscle_tone1.71970906
53MP0010030_abnormal_orbit_morphology1.69863006
54MP0001984_abnormal_olfaction1.69804988
55MP0001672_abnormal_embryogenesis/_devel1.68984246
56MP0005380_embryogenesis_phenotype1.68984246
57MP0002080_prenatal_lethality1.62260549
58MP0003879_abnormal_hair_cell1.56271074
59MP0000313_abnormal_cell_death1.55923582
60MP0004811_abnormal_neuron_physiology1.53017737
61MP0002909_abnormal_adrenal_gland1.49924710
62MP0008569_lethality_at_weaning1.49392849
63MP0002085_abnormal_embryonic_tissue1.47840969
64MP0001346_abnormal_lacrimal_gland1.46142853
65MP0002837_dystrophic_cardiac_calcinosis1.45806621
66MP0000778_abnormal_nervous_system1.44635145
67MP0006292_abnormal_olfactory_placode1.43729274
68MP0003984_embryonic_growth_retardation1.43135244
69MP0009672_abnormal_birth_weight1.43009836
70MP0010352_gastrointestinal_tract_polyps1.41256973
71MP0002876_abnormal_thyroid_physiology1.40734483
72MP0001188_hyperpigmentation1.38855074
73MP0002088_abnormal_embryonic_growth/wei1.36997462
74MP0004858_abnormal_nervous_system1.36560518
75MP0002066_abnormal_motor_capabilities/c1.36281869
76MP0003941_abnormal_skin_development1.35989775
77MP0002877_abnormal_melanocyte_morpholog1.33491379
78MP0006036_abnormal_mitochondrial_physio1.33398471
79MP0000358_abnormal_cell_content/1.32442695
80MP0000955_abnormal_spinal_cord1.30376509
81MP0003329_amyloid_beta_deposits1.29930716
82MP0008872_abnormal_physiological_respon1.25846914
83MP0002084_abnormal_developmental_patter1.25628874
84MP0002882_abnormal_neuron_morphology1.25534807
85MP0001293_anophthalmia1.25139987
86MP0002396_abnormal_hematopoietic_system1.23170640
87MP0000751_myopathy1.21797518
88MP0003121_genomic_imprinting1.20513326
89MP0003937_abnormal_limbs/digits/tail_de1.20272646
90MP0003186_abnormal_redox_activity1.19888609
91MP0001502_abnormal_circadian_rhythm1.19417034
92MP0002938_white_spotting1.18582801
93MP0002019_abnormal_tumor_incidence1.17770941
94MP0002210_abnormal_sex_determination1.17252881
95MP0000013_abnormal_adipose_tissue1.17084621
96MP0000537_abnormal_urethra_morphology1.15877005
97MP0000490_abnormal_crypts_of1.12119436
98MP0004197_abnormal_fetal_growth/weight/1.11122533
99MP0003315_abnormal_perineum_morphology1.10241721
100MP0010386_abnormal_urinary_bladder1.07287092
101MP0003123_paternal_imprinting1.07056604
102MP0003633_abnormal_nervous_system1.06905214
103MP0001929_abnormal_gametogenesis1.02472577
104MP0008877_abnormal_DNA_methylation1.01102324
105MP0002697_abnormal_eye_size0.99102812
106MP0002086_abnormal_extraembryonic_tissu0.98611463
107MP0003631_nervous_system_phenotype0.95361277
108MP0002069_abnormal_eating/drinking_beha0.95313692
109MP0002152_abnormal_brain_morphology0.94168394
110MP0000372_irregular_coat_pigmentation0.93183485
111MP0001727_abnormal_embryo_implantation0.92431426
112MP0001145_abnormal_male_reproductive0.92051586
113MP0002111_abnormal_tail_morphology0.91695784
114MP0001286_abnormal_eye_development0.90859910
115MP0005535_abnormal_body_temperature0.89848691
116MP0002229_neurodegeneration0.89652627
117MP0005499_abnormal_olfactory_system0.89594569
118MP0005394_taste/olfaction_phenotype0.89594569
119MP0005551_abnormal_eye_electrophysiolog0.89573569
120MP0001986_abnormal_taste_sensitivity0.85226782
121MP0005501_abnormal_skin_physiology0.84167601
122MP0000631_abnormal_neuroendocrine_gland0.84152788
123MP0001664_abnormal_digestion0.84141329
124MP0003646_muscle_fatigue0.83761432
125MP0002160_abnormal_reproductive_system0.83499914
126MP0001963_abnormal_hearing_physiology0.82520879
127MP0003890_abnormal_embryonic-extraembry0.82454492
128MP0000653_abnormal_sex_gland0.81878839
129MP0004085_abnormal_heartbeat0.81585924
130MP0008874_decreased_physiological_sensi0.81560969
131MP0005384_cellular_phenotype0.81214948
132MP0003183_abnormal_peptide_metabolism0.80058018
133MP0003136_yellow_coat_color0.79812179
134MP0003567_abnormal_fetal_cardiomyocyte0.79527446
135MP0002234_abnormal_pharynx_morphology0.77674367
136MP0005408_hypopigmentation0.77255768
137MP0006035_abnormal_mitochondrial_morpho0.76636100
138MP0004742_abnormal_vestibular_system0.75841812
139MP0008789_abnormal_olfactory_epithelium0.75013305
140MP0000566_synostosis0.74886742
141MP0004215_abnormal_myocardial_fiber0.74364846
142MP0002092_abnormal_eye_morphology0.73331251
143MP0002332_abnormal_exercise_endurance0.72830619
144MP0004885_abnormal_endolymph0.71801374
145MP0002233_abnormal_nose_morphology0.70483885
146MP0002752_abnormal_somatic_nervous0.69843476
147MP0008995_early_reproductive_senescence0.69031074
148MP0002638_abnormal_pupillary_reflex0.68856635
149MP0001177_atelectasis0.68597581
150MP0004484_altered_response_of0.67423301
151MP0001881_abnormal_mammary_gland0.67212910
152MP0001119_abnormal_female_reproductive0.66908901
153MP0005621_abnormal_cell_physiology0.66877142
154MP0003632_abnormal_nervous_system0.65124599
155MP0009703_decreased_birth_body0.64483990
156MP0004233_abnormal_muscle_weight0.64457382
157MP0003221_abnormal_cardiomyocyte_apopto0.64227761
158MP0005076_abnormal_cell_differentiation0.63518401
159MP0004185_abnormal_adipocyte_glucose0.63414146
160MP0004145_abnormal_muscle_electrophysio0.62699800
161MP0001943_abnormal_respiration0.62457515
162MP0003634_abnormal_glial_cell0.61430518
163MP0009379_abnormal_foot_pigmentation0.61108173
164MP0000428_abnormal_craniofacial_morphol0.61070797
165MP0002090_abnormal_vision0.59952275
166MP0008260_abnormal_autophagy0.59933581
167MP0004043_abnormal_pH_regulation0.59095330
168MP0000049_abnormal_middle_ear0.58341087
169MP0002163_abnormal_gland_morphology0.57973391
170MP0003119_abnormal_digestive_system0.57897515
171MP0001661_extended_life_span0.56661734
172MP0003699_abnormal_female_reproductive0.56113305
173MP0005379_endocrine/exocrine_gland_phen0.56093300
174MP0002161_abnormal_fertility/fecundity0.56066347
175MP0002751_abnormal_autonomic_nervous0.54916106
176MP0004808_abnormal_hematopoietic_stem0.53982712
177MP0003861_abnormal_nervous_system0.53737505
178MP0005171_absent_coat_pigmentation0.53366895
179MP0004036_abnormal_muscle_relaxation0.53313971
180MP0000647_abnormal_sebaceous_gland0.53077984
181MP0003698_abnormal_male_reproductive0.52745481
182MP0006072_abnormal_retinal_apoptosis0.52272181
183MP0002082_postnatal_lethality0.51085120
184MP0010770_preweaning_lethality0.51085120
185MP0005623_abnormal_meninges_morphology0.50633252
186MP0003755_abnormal_palate_morphology0.50388343
187MP0003705_abnormal_hypodermis_morpholog0.50274328
188MP0004147_increased_porphyrin_level0.49860685
189MP0003943_abnormal_hepatobiliary_system0.49480149
190MP0003956_abnormal_body_size0.49393365
191MP0002653_abnormal_ependyma_morphology0.49334979
192MP0000627_abnormal_mammary_gland0.48916679
193MP0001186_pigmentation_phenotype0.48624840

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.79710696
2Chromosomal breakage induced by crosslinking agents (HP:0003221)6.63023868
3Chromsome breakage (HP:0040012)5.99619844
4Atonic seizures (HP:0010819)5.59650646
5Myokymia (HP:0002411)5.53580872
6Focal seizures (HP:0007359)5.36823649
7Epileptic encephalopathy (HP:0200134)5.03962188
8Febrile seizures (HP:0002373)4.89599371
9Visual hallucinations (HP:0002367)4.87978408
10Absence seizures (HP:0002121)4.49430160
11Meckel diverticulum (HP:0002245)4.44848836
12Abnormality of the preputium (HP:0100587)4.19121696
13Abnormality of the ileum (HP:0001549)4.18777514
14Aplasia/Hypoplasia of the uvula (HP:0010293)4.14149278
15Abnormality of chromosome stability (HP:0003220)4.11694782
16Dialeptic seizures (HP:0011146)4.06917587
17Progressive cerebellar ataxia (HP:0002073)4.01198804
18Generalized tonic-clonic seizures (HP:0002069)3.93769549
19Limb dystonia (HP:0002451)3.88837825
20Reticulocytopenia (HP:0001896)3.83300832
21Birth length less than 3rd percentile (HP:0003561)3.82513294
22Pheochromocytoma (HP:0002666)3.82387796
23Hyperventilation (HP:0002883)3.81474678
24Small intestinal stenosis (HP:0012848)3.63898371
25Duodenal stenosis (HP:0100867)3.63898371
26Abnormal hair whorl (HP:0010721)3.61463761
27Neuroendocrine neoplasm (HP:0100634)3.56285862
28Failure to thrive in infancy (HP:0001531)3.43377495
29Polyphagia (HP:0002591)3.42495944
30Aplasia/Hypoplasia of the sacrum (HP:0008517)3.36844096
31Abnormal eating behavior (HP:0100738)3.32677862
32Acute necrotizing encephalopathy (HP:0006965)3.25585630
33Abnormal mitochondria in muscle tissue (HP:0008316)3.19769247
34Microvesicular hepatic steatosis (HP:0001414)3.13893482
35Broad-based gait (HP:0002136)3.10520971
36Increased nuchal translucency (HP:0010880)3.08765328
37Impaired vibration sensation in the lower limbs (HP:0002166)3.04663628
38Progressive inability to walk (HP:0002505)3.01631875
39Abnormality of the carotid arteries (HP:0005344)2.99472142
40Myelodysplasia (HP:0002863)2.99223996
41Abnormality of the duodenum (HP:0002246)2.98508541
42Progressive macrocephaly (HP:0004481)2.92914497
43Abnormality of cochlea (HP:0000375)2.92243527
44Poor suck (HP:0002033)2.89804079
45Gait imbalance (HP:0002141)2.89793941
46Abnormal lung lobation (HP:0002101)2.88921952
47Abnormality of glycolysis (HP:0004366)2.83677073
48Gaze-evoked nystagmus (HP:0000640)2.83646025
49Truncal ataxia (HP:0002078)2.82787396
50Anxiety (HP:0000739)2.81888795
51Oligomenorrhea (HP:0000876)2.81460517
52Increased serum pyruvate (HP:0003542)2.78071360
53Depression (HP:0000716)2.73739473
54Nephroblastoma (Wilms tumor) (HP:0002667)2.71238156
55Absent radius (HP:0003974)2.65221441
56Abnormality of the labia minora (HP:0012880)2.63943625
57Amblyopia (HP:0000646)2.63891898
58Congenital primary aphakia (HP:0007707)2.62882774
59Mitochondrial inheritance (HP:0001427)2.61987106
60Poor eye contact (HP:0000817)2.61081400
61Dysdiadochokinesis (HP:0002075)2.60515265
62Selective tooth agenesis (HP:0001592)2.58239025
63Ankle clonus (HP:0011448)2.57874375
64Epileptiform EEG discharges (HP:0011182)2.57021885
65Embryonal renal neoplasm (HP:0011794)2.54909653
66Resting tremor (HP:0002322)2.52942288
67Triphalangeal thumb (HP:0001199)2.51891815
68Medial flaring of the eyebrow (HP:0010747)2.51677499
69Hypoventilation (HP:0002791)2.50381937
70Multiple enchondromatosis (HP:0005701)2.50351346
71Clubbing of toes (HP:0100760)2.50056034
72Aplasia involving forearm bones (HP:0009822)2.47859617
73Absent forearm bone (HP:0003953)2.47859617
74Nephrogenic diabetes insipidus (HP:0009806)2.45564157
75Facial cleft (HP:0002006)2.43440473
76Abnormal social behavior (HP:0012433)2.42065634
77Impaired social interactions (HP:0000735)2.42065634
78Acute encephalopathy (HP:0006846)2.40542296
79Abnormality of binocular vision (HP:0011514)2.40291851
80Diplopia (HP:0000651)2.40291851
81EEG with generalized epileptiform discharges (HP:0011198)2.39697564
82Pancytopenia (HP:0001876)2.39115852
83Bradykinesia (HP:0002067)2.38527431
84Sloping forehead (HP:0000340)2.37925160
85Horseshoe kidney (HP:0000085)2.36843707
86Action tremor (HP:0002345)2.36255001
87Hypoplasia of the capital femoral epiphysis (HP:0003090)2.35432465
88Ectopic kidney (HP:0000086)2.34421950
89Inability to walk (HP:0002540)2.34295411
90Specific learning disability (HP:0001328)2.33371908
91Urinary bladder sphincter dysfunction (HP:0002839)2.31852616
92Hypothermia (HP:0002045)2.31245189
93Fetal akinesia sequence (HP:0001989)2.31009003
94Colon cancer (HP:0003003)2.30550489
95Drooling (HP:0002307)2.28174755
96Excessive salivation (HP:0003781)2.28174755
97Hypsarrhythmia (HP:0002521)2.27896060
98Dysmetria (HP:0001310)2.27501482
99Breast hypoplasia (HP:0003187)2.26443538
100Increased CSF lactate (HP:0002490)2.25354111
101Abnormal number of incisors (HP:0011064)2.24551463
102Abnormality of cells of the erythroid lineage (HP:0012130)2.23494423
103Macrocytic anemia (HP:0001972)2.22687366
104Supranuclear gaze palsy (HP:0000605)2.22464333
105Abnormality of the anterior horn cell (HP:0006802)2.21082066
106Degeneration of anterior horn cells (HP:0002398)2.21082066
107Esotropia (HP:0000565)2.20950103
108Absent thumb (HP:0009777)2.20630943
109Short thumb (HP:0009778)2.20508394
110Abnormal number of erythroid precursors (HP:0012131)2.19585807
111Cortical dysplasia (HP:0002539)2.19550750
112Medulloblastoma (HP:0002885)2.17610411
113Narrow nasal bridge (HP:0000446)2.17396038
114Neoplasm of the peripheral nervous system (HP:0100007)2.16450940
115Cafe-au-lait spot (HP:0000957)2.15632465
116Progressive muscle weakness (HP:0003323)2.15465781
117Urinary urgency (HP:0000012)2.14517278
118Hyperthyroidism (HP:0000836)2.14439693
119Postural instability (HP:0002172)2.14392375
120Morphological abnormality of the inner ear (HP:0011390)2.14160969
121Hepatocellular necrosis (HP:0001404)2.13922933
122Patellar aplasia (HP:0006443)2.13309285
123Type I transferrin isoform profile (HP:0003642)2.12762553
124Genital tract atresia (HP:0001827)2.12751917
125Scanning speech (HP:0002168)2.12243158
126Termporal pattern (HP:0011008)2.11783887
127Insidious onset (HP:0003587)2.11783887
128Bone marrow hypocellularity (HP:0005528)2.10763639
129Vaginal atresia (HP:0000148)2.09944968
130Impaired pain sensation (HP:0007328)2.09098635
131Abnormality of pain sensation (HP:0010832)2.09098635
132Choanal atresia (HP:0000453)2.08084749
133Mutism (HP:0002300)2.07067908
134Increased hepatocellular lipid droplets (HP:0006565)2.06693278
135Proximal placement of thumb (HP:0009623)2.06212072
136Cerebral edema (HP:0002181)2.06184948
137Abnormality of the lower motor neuron (HP:0002366)2.06049147
138Duplicated collecting system (HP:0000081)2.05882164
139Spastic gait (HP:0002064)2.05006695
140Status epilepticus (HP:0002133)2.02919224
141Duplication of thumb phalanx (HP:0009942)2.02881898
142Arteriovenous malformation (HP:0100026)2.01833093
143Carpal bone hypoplasia (HP:0001498)2.00978776
144Focal dystonia (HP:0004373)2.00886155
145Aplasia/Hypoplasia of the patella (HP:0006498)2.00581376
146Squamous cell carcinoma (HP:0002860)1.99778026
147Psychosis (HP:0000709)1.97790366
148Reduced antithrombin III activity (HP:0001976)1.97282570
149Impaired vibratory sensation (HP:0002495)1.97256060
150Torticollis (HP:0000473)1.96810001
151Secondary amenorrhea (HP:0000869)1.96417057
152Protruding tongue (HP:0010808)1.96393215
153Abnormal umbilical cord blood vessels (HP:0011403)1.96326994
154Single umbilical artery (HP:0001195)1.96326994
155Abnormality of the fetal cardiovascular system (HP:0010948)1.96326994
156Blue irides (HP:0000635)1.96044954
157Increased serum lactate (HP:0002151)1.95880996
158Impaired smooth pursuit (HP:0007772)1.95184009
159Hypoplastic pelvis (HP:0008839)1.94845621
160Generalized hypotonia (HP:0001290)1.94268223
161Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.94187121
162Absent epiphyses (HP:0010577)1.94187121
163Overlapping toe (HP:0001845)1.93919170
164Ependymoma (HP:0002888)1.93559323
165Generalized myoclonic seizures (HP:0002123)1.93327253
166Abnormality of the umbilical cord (HP:0010881)1.91834380
167Dysmetric saccades (HP:0000641)1.91285401
168Delusions (HP:0000746)1.91278949
169Poor coordination (HP:0002370)1.90587620
170Hepatic necrosis (HP:0002605)1.90382236
171Agitation (HP:0000713)1.89356897
172Optic disc pallor (HP:0000543)1.89188288
173Irregular epiphyses (HP:0010582)1.88746798
174Hemiparesis (HP:0001269)1.88682673
175Volvulus (HP:0002580)1.88563026
176Deviation of the thumb (HP:0009603)1.87868572
177Abnormality of the corticospinal tract (HP:0002492)1.87576015
178Broad distal phalanx of finger (HP:0009836)1.86738384
179Pallor (HP:0000980)1.86537408
180Sleep apnea (HP:0010535)1.86254407
181Neoplasm of the colon (HP:0100273)1.85890262
182Genetic anticipation (HP:0003743)1.85307791
183Aplastic anemia (HP:0001915)1.83783830
184Gait ataxia (HP:0002066)1.83270778
185Lipid accumulation in hepatocytes (HP:0006561)1.82849092
186Tracheoesophageal fistula (HP:0002575)1.82497300
187Megaloblastic anemia (HP:0001889)1.78239451
188Rough bone trabeculation (HP:0100670)1.76321210
189Abnormality of the renal collecting system (HP:0004742)1.76211075
190Abnormality of methionine metabolism (HP:0010901)1.75818543
191Embryonal neoplasm (HP:0002898)1.73216244
192Cleft eyelid (HP:0000625)1.73126264

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.95860299
2CDC74.77152435
3CASK4.40265196
4MAP3K124.28589360
5NTRK33.98882969
6TTK3.65609592
7MAP3K43.59820397
8VRK23.44148228
9MAP2K73.36797480
10WEE13.35649438
11SRPK13.17129644
12EIF2AK13.04178624
13PBK2.90431676
14MAP3K92.89843575
15PLK42.86833665
16EPHA42.63742846
17MINK12.46682750
18NME22.36710891
19MAP2K42.35218647
20MARK12.30419324
21BRSK22.26600155
22CDK192.19309572
23PLK22.15959108
24DAPK22.05522586
25PLK11.97962413
26NTRK21.96935682
27TSSK61.90583751
28DAPK11.90098218
29ZAK1.88971660
30GRK51.80447105
31VRK11.77757832
32STK161.77676082
33ARAF1.74427433
34CHEK21.73464276
35AKT31.62481140
36PNCK1.62368778
37AURKB1.61931660
38ATR1.61389770
39EIF2AK31.60069316
40TAF11.55653174
41NEK21.52528202
42MKNK11.48007901
43SMG11.41701063
44MST41.34375832
45MAPK131.33241867
46PRKCG1.32624983
47CDK71.32600481
48PRPF4B1.30214256
49NTRK11.29102285
50NME11.28928177
51CDK51.27583189
52OXSR11.26853604
53CCNB11.25149964
54PAK61.25025285
55AURKA1.18734981
56CAMKK21.17061711
57CHEK11.15867615
58MKNK21.13713795
59KSR21.13381718
60CAMK2A1.12350824
61KSR11.11639839
62CAMKK11.10219748
63PDK31.09057612
64PDK41.09057612
65TNIK1.08223197
66STK41.08187298
67CDK81.05328093
68EIF2AK21.05010412
69GRK71.02647548
70SIK31.01360776
71SGK2231.01266340
72SGK4941.01266340
73SGK21.01030183
74RIPK40.99722041
75UHMK10.98851067
76MAP3K80.98551167
77PAK40.97004696
78SCYL20.96239920
79CDK180.93139731
80TESK20.93037782
81CAMK2B0.91473301
82ADRBK20.90143191
83NEK10.89914819
84FES0.89083379
85MAP3K100.88519363
86CDK140.87655682
87BRAF0.87242308
88CDK150.86377316
89ATM0.85211802
90CDK40.84358381
91PASK0.84131878
92STK100.83455044
93STK38L0.80252548
94LATS20.79930995
95TRIM280.78249483
96RPS6KB20.78166107
97CSNK1G20.76884345
98TNK20.76443732
99NUAK10.76428471
100CLK10.74005351
101WNK30.73850201
102CDK11A0.73094419
103MYLK0.72527723
104PRKCE0.71211853
105RPS6KA40.70306251
106PTK2B0.69275410
107CDK10.68875626
108ADRBK10.68855342
109STK380.65786830
110EPHA20.65474401
111KDR0.64069845
112MST1R0.63907447
113PHKG20.63799503
114PHKG10.63799503
115CDK20.63589063
116CAMK10.63305499
117BCR0.62559932
118SGK30.62107121
119SIK20.61771851
120CAMK2G0.61577734
121CAMK2D0.61563008
122BCKDK0.61185227
123CSNK2A10.58988732
124PRKCH0.57672839
125CSNK2A20.57389768
126BMPR20.56293704
127ALK0.56012591
128FER0.55594256
129MAPKAPK50.54689770
130MELK0.54484397
131DAPK30.53590232
132SGK10.52260906
133STK110.51794084
134PDK20.50504097
135MAP3K20.50038814
136PAK30.49999857
137DYRK1A0.48531373
138MAP3K130.48447714
139CSNK1G30.48239216
140PRKD30.48231040
141CDK120.47979393
142LIMK10.47577215
143RET0.47441432
144IRAK30.47349386
145MAP2K10.44460899
146LMTK20.44056581
147PINK10.42639837
148PAK10.39482085
149RPS6KA20.39099975
150TLK10.38999169
151RAF10.38226880
152MAP3K10.37158299
153RPS6KA30.37041907
154PLK30.36993276
155PRKACA0.36315863
156CSNK1G10.36119747
157ROCK20.35761913
158BMPR1B0.35126480
159ERBB40.35119809
160CDK90.34397049
161CDK60.34366299
162CSNK1A1L0.34254234
163FGR0.34219918
164STK30.33811599
165BRSK10.33037288
166PRKDC0.32991137
167AKT20.32662247
168CSNK1E0.30687089
169PRKCI0.29616167
170CDK30.29467949
171EEF2K0.29245943
172TESK10.25678650
173DYRK30.25275168
174BRD40.22515846
175MET0.20882918
176RPS6KA50.20260950
177MAPK140.15918076
178DYRK20.14920209
179LRRK20.14772788

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.85676678
2Mismatch repair_Homo sapiens_hsa034304.65193162
3Synaptic vesicle cycle_Homo sapiens_hsa047214.38910718
4Nicotine addiction_Homo sapiens_hsa050334.19672002
5Collecting duct acid secretion_Homo sapiens_hsa049663.47926813
6Base excision repair_Homo sapiens_hsa034103.28536207
7Homologous recombination_Homo sapiens_hsa034403.28183842
8Non-homologous end-joining_Homo sapiens_hsa034502.95408100
9GABAergic synapse_Homo sapiens_hsa047272.81300238
10Fanconi anemia pathway_Homo sapiens_hsa034602.74178688
11Nucleotide excision repair_Homo sapiens_hsa034202.73304955
12Cell cycle_Homo sapiens_hsa041102.72271281
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72136769
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.69023701
15Spliceosome_Homo sapiens_hsa030402.68199947
16Ribosome_Homo sapiens_hsa030102.61967289
17Oxidative phosphorylation_Homo sapiens_hsa001902.58603751
18Olfactory transduction_Homo sapiens_hsa047402.58080785
19Morphine addiction_Homo sapiens_hsa050322.46242336
20One carbon pool by folate_Homo sapiens_hsa006702.42527484
21Amphetamine addiction_Homo sapiens_hsa050312.39819006
22Circadian entrainment_Homo sapiens_hsa047132.34591599
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34004053
24RNA transport_Homo sapiens_hsa030132.24833443
25Long-term potentiation_Homo sapiens_hsa047202.22777099
26Vibrio cholerae infection_Homo sapiens_hsa051102.22482415
27RNA polymerase_Homo sapiens_hsa030202.15530437
28Dopaminergic synapse_Homo sapiens_hsa047282.12063976
29Glutamatergic synapse_Homo sapiens_hsa047242.10821641
30Pyrimidine metabolism_Homo sapiens_hsa002402.09288450
31Parkinsons disease_Homo sapiens_hsa050122.01588582
32Taste transduction_Homo sapiens_hsa047421.94188954
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82227553
34Insulin secretion_Homo sapiens_hsa049111.78889510
35Serotonergic synapse_Homo sapiens_hsa047261.78508988
36Cocaine addiction_Homo sapiens_hsa050301.75789975
37Salivary secretion_Homo sapiens_hsa049701.75521595
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68187039
39Long-term depression_Homo sapiens_hsa047301.63125837
40Alzheimers disease_Homo sapiens_hsa050101.61854146
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61023579
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.58598314
43Cholinergic synapse_Homo sapiens_hsa047251.58184612
44Renin secretion_Homo sapiens_hsa049241.54796855
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.53451644
46Biosynthesis of amino acids_Homo sapiens_hsa012301.52328644
47Gastric acid secretion_Homo sapiens_hsa049711.48795137
48Protein export_Homo sapiens_hsa030601.45938384
49Calcium signaling pathway_Homo sapiens_hsa040201.43360414
50Cardiac muscle contraction_Homo sapiens_hsa042601.43047660
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41097730
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.37481814
53RNA degradation_Homo sapiens_hsa030181.36868570
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33058539
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32230483
56Huntingtons disease_Homo sapiens_hsa050161.31919350
57Oxytocin signaling pathway_Homo sapiens_hsa049211.27855476
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27535710
59Folate biosynthesis_Homo sapiens_hsa007901.24656675
60Purine metabolism_Homo sapiens_hsa002301.22145626
61mRNA surveillance pathway_Homo sapiens_hsa030151.21026070
62Carbon metabolism_Homo sapiens_hsa012001.19856269
63Basal transcription factors_Homo sapiens_hsa030221.19222223
64Gap junction_Homo sapiens_hsa045401.15563687
65Sulfur relay system_Homo sapiens_hsa041221.15274947
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14566895
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13867562
68p53 signaling pathway_Homo sapiens_hsa041151.05891168
69GnRH signaling pathway_Homo sapiens_hsa049121.04870327
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04692569
71Vitamin B6 metabolism_Homo sapiens_hsa007501.02845741
72Rheumatoid arthritis_Homo sapiens_hsa053231.01126852
73Fatty acid elongation_Homo sapiens_hsa000620.99908173
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98026008
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96735745
76Type I diabetes mellitus_Homo sapiens_hsa049400.95716743
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95099307
78Phototransduction_Homo sapiens_hsa047440.89978182
79cAMP signaling pathway_Homo sapiens_hsa040240.89765706
80Glutathione metabolism_Homo sapiens_hsa004800.88887184
81Pentose phosphate pathway_Homo sapiens_hsa000300.85921006
82Estrogen signaling pathway_Homo sapiens_hsa049150.83557963
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83012457
84Propanoate metabolism_Homo sapiens_hsa006400.76566417
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75753387
86Phagosome_Homo sapiens_hsa041450.75348864
87Oocyte meiosis_Homo sapiens_hsa041140.74391553
88N-Glycan biosynthesis_Homo sapiens_hsa005100.74105778
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72113626
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72008039
91Steroid biosynthesis_Homo sapiens_hsa001000.72003679
92Melanogenesis_Homo sapiens_hsa049160.71677634
93Type II diabetes mellitus_Homo sapiens_hsa049300.70637642
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.70600061
95ErbB signaling pathway_Homo sapiens_hsa040120.70287316
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69999507
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69567364
98Selenocompound metabolism_Homo sapiens_hsa004500.69174830
99Pyruvate metabolism_Homo sapiens_hsa006200.67833116
100Axon guidance_Homo sapiens_hsa043600.67793524
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67585726
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66822468
103Glioma_Homo sapiens_hsa052140.61725338
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60426984
105Epstein-Barr virus infection_Homo sapiens_hsa051690.59935655
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56874082
107Alcoholism_Homo sapiens_hsa050340.56664021
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55013477
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54599797
110Thyroid hormone synthesis_Homo sapiens_hsa049180.53859510
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53007043
112Dilated cardiomyopathy_Homo sapiens_hsa054140.52194303
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50509494
114Glucagon signaling pathway_Homo sapiens_hsa049220.49560730
115Metabolic pathways_Homo sapiens_hsa011000.49481430
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49227510
117MAPK signaling pathway_Homo sapiens_hsa040100.48790309
118Fructose and mannose metabolism_Homo sapiens_hsa000510.46689974
119Lysine degradation_Homo sapiens_hsa003100.46521187
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46402968
121Pancreatic secretion_Homo sapiens_hsa049720.44894417
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.44423995
123Systemic lupus erythematosus_Homo sapiens_hsa053220.43988969
124Butanoate metabolism_Homo sapiens_hsa006500.43886334
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.42892112
126Galactose metabolism_Homo sapiens_hsa000520.41970239
127Viral carcinogenesis_Homo sapiens_hsa052030.41501642
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40899722
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39869224
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39616529
131Ras signaling pathway_Homo sapiens_hsa040140.33767557
132Dorso-ventral axis formation_Homo sapiens_hsa043200.32928326
133HTLV-I infection_Homo sapiens_hsa051660.32308032
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31919165
135Thyroid cancer_Homo sapiens_hsa052160.31742903
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31698172
137Fatty acid metabolism_Homo sapiens_hsa012120.30732454
138Small cell lung cancer_Homo sapiens_hsa052220.30565691
139Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29482488
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.29033868
141Inositol phosphate metabolism_Homo sapiens_hsa005620.28801968
142Arginine and proline metabolism_Homo sapiens_hsa003300.28405239
143Basal cell carcinoma_Homo sapiens_hsa052170.27938857
144Prion diseases_Homo sapiens_hsa050200.27384709
145Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26368482
146MicroRNAs in cancer_Homo sapiens_hsa052060.25456196
147Insulin signaling pathway_Homo sapiens_hsa049100.24937321
148Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24696723
149Regulation of autophagy_Homo sapiens_hsa041400.24065256
150Central carbon metabolism in cancer_Homo sapiens_hsa052300.24039072
151Neurotrophin signaling pathway_Homo sapiens_hsa047220.24003895
152Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23389256
153Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23344971
154Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23267533
155Circadian rhythm_Homo sapiens_hsa047100.22983159
156Ovarian steroidogenesis_Homo sapiens_hsa049130.21428609
157Rap1 signaling pathway_Homo sapiens_hsa040150.20374458
158Phenylalanine metabolism_Homo sapiens_hsa003600.20304443
159Choline metabolism in cancer_Homo sapiens_hsa052310.20181171
160Sulfur metabolism_Homo sapiens_hsa009200.19928314
161Hippo signaling pathway_Homo sapiens_hsa043900.19753290
162Proteasome_Homo sapiens_hsa030500.19431280
163Bladder cancer_Homo sapiens_hsa052190.18842234
164Endocytosis_Homo sapiens_hsa041440.18674371
165Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.18433234
166Hedgehog signaling pathway_Homo sapiens_hsa043400.17957188
167Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16715916
168African trypanosomiasis_Homo sapiens_hsa051430.16269744
169Shigellosis_Homo sapiens_hsa051310.15625734
170Melanoma_Homo sapiens_hsa052180.14953388
171Glycerophospholipid metabolism_Homo sapiens_hsa005640.14809477
172Wnt signaling pathway_Homo sapiens_hsa043100.14660298
173Herpes simplex infection_Homo sapiens_hsa051680.12534118
174TGF-beta signaling pathway_Homo sapiens_hsa043500.09662316
175Tyrosine metabolism_Homo sapiens_hsa003500.07535540
176Colorectal cancer_Homo sapiens_hsa052100.06914450
177Peroxisome_Homo sapiens_hsa041460.06649050
178Apoptosis_Homo sapiens_hsa042100.06510505
179Fatty acid degradation_Homo sapiens_hsa000710.04814786
180Pancreatic cancer_Homo sapiens_hsa052120.04263297
181Prostate cancer_Homo sapiens_hsa052150.03907577

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