ZXDA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of two duplicated zinc finger genes on chromosome Xp11. This gene is the telomeric copy; GeneID 158586 ZXDB is the more centromeric copy. The two genes have 98% nucleotide sequence similarity, and the predicted proteins contain 10 tandem zinc finger motifs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.33962135
2regulation of gamma-delta T cell differentiation (GO:0045586)5.30962966
3positive thymic T cell selection (GO:0045059)5.22588805
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.89103592
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.89103592
6regulation of gamma-delta T cell activation (GO:0046643)4.76032050
7antigen processing and presentation of endogenous antigen (GO:0019883)4.51779794
8positive T cell selection (GO:0043368)4.32296582
9thymic T cell selection (GO:0045061)4.31255064
10regulation of interleukin-12 biosynthetic process (GO:0045075)4.25726807
11positive regulation of histone deacetylation (GO:0031065)4.24077510
12JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)4.15994244
13T cell selection (GO:0045058)3.97690255
14tolerance induction (GO:0002507)3.81180315
15positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.76281736
16embryonic process involved in female pregnancy (GO:0060136)3.69122552
17negative thymic T cell selection (GO:0045060)3.67136042
18negative T cell selection (GO:0043383)3.65706232
19negative regulation of erythrocyte differentiation (GO:0045647)3.56132092
20nuclear pore complex assembly (GO:0051292)3.47979970
21histone H3-K36 demethylation (GO:0070544)3.43740787
22response to interleukin-15 (GO:0070672)3.42092553
23NIK/NF-kappaB signaling (GO:0038061)3.40709253
24response to laminar fluid shear stress (GO:0034616)3.40139634
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.34944264
26leukocyte aggregation (GO:0070486)3.33782783
27T cell migration (GO:0072678)3.30847334
28natural killer cell differentiation (GO:0001779)3.30216453
29positive regulation of B cell differentiation (GO:0045579)3.25694019
30positive regulation of natural killer cell differentiation (GO:0032825)3.21677047
31protein localization to endosome (GO:0036010)3.13741920
32negative regulation of cell killing (GO:0031342)3.12394754
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.12394754
34membrane protein intracellular domain proteolysis (GO:0031293)3.08348117
35positive regulation by organism of defense response of other organism involved in symbiotic interact3.01516992
36modulation by symbiont of host immune response (GO:0052553)3.01516992
37positive regulation by symbiont of host defense response (GO:0052509)3.01516992
38modulation by symbiont of host defense response (GO:0052031)3.01516992
39modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.01516992
40modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.01516992
41phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.99312516
42regulation of interferon-beta biosynthetic process (GO:0045357)2.95411376
43regulation of B cell differentiation (GO:0045577)2.94276683
44definitive hemopoiesis (GO:0060216)2.94158929
45B cell receptor signaling pathway (GO:0050853)2.89781687
46positive regulation of interleukin-2 production (GO:0032743)2.88475480
47positive regulation of protein deacetylation (GO:0090312)2.86982427
48regulation of B cell receptor signaling pathway (GO:0050855)2.83847656
49regulation of T cell tolerance induction (GO:0002664)2.83459607
50positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.82969361
51regulation of interleukin-2 biosynthetic process (GO:0045076)2.80751030
52myeloid dendritic cell differentiation (GO:0043011)2.78302331
53modulation by symbiont of host cellular process (GO:0044068)2.78007105
54dosage compensation (GO:0007549)2.77932571
55endothelial cell chemotaxis (GO:0035767)2.77312692
56hepatocyte apoptotic process (GO:0097284)2.73773595
57T cell receptor signaling pathway (GO:0050852)2.72085172
58regulation of T-helper 2 cell differentiation (GO:0045628)2.71668113
59negative regulation of interleukin-12 production (GO:0032695)2.69221180
60positive regulation of granulocyte differentiation (GO:0030854)2.68970256
61response to muramyl dipeptide (GO:0032495)2.68517571
62CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.67389453
63T-helper cell differentiation (GO:0042093)2.67389453
64B cell homeostasis (GO:0001782)2.65481877
65T cell costimulation (GO:0031295)2.63469548
66positive regulation of isotype switching (GO:0045830)2.62766847
67regulation of T-helper 1 cell differentiation (GO:0045625)2.62548098
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.60887080
69skeletal muscle adaptation (GO:0043501)2.59825649
70antigen receptor-mediated signaling pathway (GO:0050851)2.57537688
71negative regulation of T-helper cell differentiation (GO:0045623)2.57369714
72negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.57369714
73viral transcription (GO:0019083)2.56926256
74striated muscle atrophy (GO:0014891)2.55324119
75positive regulation of Rap GTPase activity (GO:0032854)2.55191127
76positive regulation of myotube differentiation (GO:0010831)2.54970919
77lymphocyte costimulation (GO:0031294)2.54658152
78myeloid dendritic cell activation (GO:0001773)2.54210767
79nuclear pore organization (GO:0006999)2.52255642
80pore complex assembly (GO:0046931)2.52125792
81mRNA transcription (GO:0009299)2.51342387
82mature B cell differentiation involved in immune response (GO:0002313)2.50754725
83JAK-STAT cascade (GO:0007259)2.49488048
84apoptotic process involved in morphogenesis (GO:0060561)2.47380363
85regulation of type I interferon-mediated signaling pathway (GO:0060338)2.46844022
86cortical actin cytoskeleton organization (GO:0030866)2.46561978
87positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.46313417
88mature B cell differentiation (GO:0002335)2.45464508
89modulation by virus of host process (GO:0019054)2.45177691
90negative regulation of heart growth (GO:0061117)2.44188869
91negative regulation of cardiac muscle tissue growth (GO:0055022)2.44188869
92regulation of extracellular matrix disassembly (GO:0010715)2.43650598
93cellular extravasation (GO:0045123)2.43305482
94negative regulation of toll-like receptor signaling pathway (GO:0034122)2.42863325
95CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.41258572
96macrophage activation involved in immune response (GO:0002281)2.40905969
97Rap protein signal transduction (GO:0032486)2.40555338
98regulation of natural killer cell differentiation (GO:0032823)2.39956460
99peptidyl-threonine phosphorylation (GO:0018107)2.38990057
100cytoplasmic mRNA processing body assembly (GO:0033962)2.38963615
101regulation of alpha-beta T cell proliferation (GO:0046640)2.38754706
102regulation of RNA export from nucleus (GO:0046831)2.38138867
103insulin-like growth factor receptor signaling pathway (GO:0048009)2.36698602
104response to peptidoglycan (GO:0032494)2.36554723
105regulation of NFAT protein import into nucleus (GO:0051532)2.36024140
106CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.35403447
107T cell homeostasis (GO:0043029)2.34910097
108peptidyl-lysine dimethylation (GO:0018027)2.34833123
109regulation of cholesterol homeostasis (GO:2000188)2.34474241
110regulation of histone deacetylation (GO:0031063)2.34103537
111peptidyl-threonine modification (GO:0018210)2.33914032
112positive regulation of keratinocyte differentiation (GO:0045618)2.33693589
113cellular response to ethanol (GO:0071361)2.32173726
114translational termination (GO:0006415)2.31738460
115regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.30548901
116lymph node development (GO:0048535)2.29718567
117positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.29698130
118positive regulation of cytokine biosynthetic process (GO:0042108)2.28866431
119regulation of necroptotic process (GO:0060544)2.28641679
120gland morphogenesis (GO:0022612)2.28538484
121alpha-beta T cell activation (GO:0046631)2.28298384
122germinal center formation (GO:0002467)2.28295392
123negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.28262140
124cytoskeletal anchoring at plasma membrane (GO:0007016)2.28256641
125activation of JUN kinase activity (GO:0007257)2.27964168
126lymphocyte homeostasis (GO:0002260)2.27917059
127positive regulation of interferon-alpha production (GO:0032727)2.27518338
128skin morphogenesis (GO:0043589)2.27382197
129interferon-gamma production (GO:0032609)2.27332129
130natural killer cell activation (GO:0030101)2.27295906
131cellular response to interleukin-15 (GO:0071350)2.27215028
132leukocyte cell-cell adhesion (GO:0007159)2.26589625
133muscle atrophy (GO:0014889)2.26309086
134mucosal-associated lymphoid tissue development (GO:0048537)2.25537908
135Peyers patch development (GO:0048541)2.25537908
136negative regulation of T cell mediated immunity (GO:0002710)2.25149343
137membrane protein ectodomain proteolysis (GO:0006509)2.24555761
138energy homeostasis (GO:0097009)2.24431041
139mannose metabolic process (GO:0006013)2.23485085
140hypotonic response (GO:0006971)2.23480699
141cellular response to epinephrine stimulus (GO:0071872)2.23467292
142response to fluid shear stress (GO:0034405)2.22389500
143regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.22194374
144positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.22167870
145cellular response to fluid shear stress (GO:0071498)2.21886790
146negative regulation of type 2 immune response (GO:0002829)2.21883047
147type I interferon signaling pathway (GO:0060337)2.21475652
148cellular response to type I interferon (GO:0071357)2.21475652
149positive regulation of alpha-beta T cell differentiation (GO:0046638)2.21439842
150regulation of natural killer cell mediated immunity (GO:0002715)2.20482883

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.83836872
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.77489876
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.69026510
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.65938441
5VDR_21846776_ChIP-Seq_THP-1_Human3.31250980
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.99608401
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.94340557
8TCF7_22412390_ChIP-Seq_EML_Mouse2.82622449
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.80715979
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.76260983
11KDM2B_26808549_Chip-Seq_DND41_Human2.68469551
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.57634816
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.51069287
14MAF_26560356_Chip-Seq_TH1_Human2.46788266
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.40690019
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36189713
17UTX_26944678_Chip-Seq_JUKART_Human2.29431980
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.24397189
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.23553584
20RUNX_20019798_ChIP-Seq_JUKART_Human2.23334741
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.23014852
22SCL_19346495_ChIP-Seq_HPC-7_Human2.22999141
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.21532714
24* VDR_24763502_ChIP-Seq_THP-1_Human2.11069109
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08598262
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.06255425
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.00798249
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93475937
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93457999
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92791302
31LXR_22292898_ChIP-Seq_THP-1_Human1.92097253
32GATA1_22025678_ChIP-Seq_K562_Human1.91801310
33KDM2B_26808549_Chip-Seq_JURKAT_Human1.89915747
34MYB_26560356_Chip-Seq_TH1_Human1.89136868
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.86675288
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.86227781
37MYB_26560356_Chip-Seq_TH2_Human1.84791936
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.81355439
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80096819
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78363661
41SPI1_23127762_ChIP-Seq_K562_Human1.78237226
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.77788379
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77334502
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.76090875
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74453855
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74346066
47MAF_26560356_Chip-Seq_TH2_Human1.64555869
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62879044
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.62474495
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62059133
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.59040417
52RACK7_27058665_Chip-Seq_MCF-7_Human1.58291635
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57640858
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.56973350
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50204748
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50129520
57KDM2B_26808549_Chip-Seq_K562_Human1.49058852
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.47533767
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46388132
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46245247
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.45912033
62TFEB_21752829_ChIP-Seq_HELA_Human1.44871707
63PU_27001747_Chip-Seq_BMDM_Mouse1.41324314
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38790405
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37301916
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37301916
67GATA1_19941826_ChIP-Seq_K562_Human1.37129833
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36220012
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31828232
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31203288
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31165879
72NCOR1_26117541_ChIP-Seq_K562_Human1.29151944
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28105582
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27527381
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.26441955
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25333139
77ATF3_27146783_Chip-Seq_COLON_Human1.24904846
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23953123
79RUNX1_27514584_Chip-Seq_MCF-7_Human1.23735845
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20444940
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.19140827
82NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19100307
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18609256
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18248712
85PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16379519
86CLOCK_20551151_ChIP-Seq_293T_Human1.16354303
87AHR_22903824_ChIP-Seq_MCF-7_Human1.13620415
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.13301082
89GATA3_27048872_Chip-Seq_THYMUS_Human1.13013600
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12417942
91CREB1_26743006_Chip-Seq_LNCaP_Human1.11241717
92CIITA_25753668_ChIP-Seq_RAJI_Human1.08856231
93ZNF263_19887448_ChIP-Seq_K562_Human1.08707189
94SPI1_23547873_ChIP-Seq_NB4_Human1.08159870
95UBF1/2_26484160_Chip-Seq_HMECs_Human1.07651935
96FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07468689
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06359813
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05138618
99GATA1_19941827_ChIP-Seq_MEL_Mouse1.03551258
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02848510
101NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02478211
102NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01968905
103ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01946925
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00679626
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00345124
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99649706
107PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99181806
108TP53_22127205_ChIP-Seq_IMR90_Human0.98496943
109CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98252572
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98081967
111SA1_27219007_Chip-Seq_ERYTHROID_Human0.97574560
112RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97349059
113* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96420407
114GATA2_19941826_ChIP-Seq_K562_Human0.95917479
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95856044
116VDR_24787735_ChIP-Seq_THP-1_Human0.95553799
117SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95540039
118SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95232621
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94109859
120SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93522137
121GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91872326
122GATA6_25053715_ChIP-Seq_YYC3_Human0.91593172
123TBX20_22328084_ChIP-Seq_HEART_Mouse0.90835720
124TBX20_22080862_ChIP-Seq_HEART_Mouse0.90835720
125SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90627595
126PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90345875

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.32602264
2MP0004510_myositis3.25769094
3MP0003300_gastrointestinal_ulcer3.25653950
4MP0002009_preneoplasia3.04750354
5MP0010352_gastrointestinal_tract_polyps3.00803913
6MP0000685_abnormal_immune_system2.95838565
7MP0005387_immune_system_phenotype2.87807795
8MP0001790_abnormal_immune_system2.87807795
9MP0003705_abnormal_hypodermis_morpholog2.80268563
10MP0003436_decreased_susceptibility_to2.67723157
11MP0001800_abnormal_humoral_immune2.57712848
12MP0005076_abnormal_cell_differentiation2.56156832
13MP0001835_abnormal_antigen_presentation2.48785296
14MP0003763_abnormal_thymus_physiology2.46899643
15MP0004947_skin_inflammation2.35099425
16MP0005000_abnormal_immune_tolerance2.24268759
17MP0002452_abnormal_antigen_presenting2.18746921
18MP0002723_abnormal_immune_serum2.09387544
19MP0008961_abnormal_basal_metabolism2.07308340
20MP0002405_respiratory_system_inflammati2.05882043
21MP0010234_abnormal_vibrissa_follicle2.05008735
22MP0008057_abnormal_DNA_replication2.02051077
23MP0002420_abnormal_adaptive_immunity1.94347108
24MP0001819_abnormal_immune_cell1.91935031
25MP0009333_abnormal_splenocyte_physiolog1.88504577
26MP0002398_abnormal_bone_marrow1.86440268
27MP0008260_abnormal_autophagy1.85950851
28MP0005671_abnormal_response_to1.84945364
29MP0009840_abnormal_foam_cell1.80624286
30MP0009278_abnormal_bone_marrow1.79492637
31MP0010155_abnormal_intestine_physiology1.78117178
32MP0004130_abnormal_muscle_cell1.77930411
33MP0004808_abnormal_hematopoietic_stem1.77770046
34MP0002166_altered_tumor_susceptibility1.71174864
35MP0003866_abnormal_defecation1.69281641
36MP0002396_abnormal_hematopoietic_system1.68468730
37MP0003646_muscle_fatigue1.68079105
38MP0005025_abnormal_response_to1.67788794
39MP0000716_abnormal_immune_system1.64267984
40MP0001873_stomach_inflammation1.63678122
41MP0002332_abnormal_exercise_endurance1.62154785
42MP0002419_abnormal_innate_immunity1.61765171
43MP0003566_abnormal_cell_adhesion1.60124060
44MP0005451_abnormal_body_composition1.57612962
45MP0000703_abnormal_thymus_morphology1.56616042
46MP0004185_abnormal_adipocyte_glucose1.55158516
47MP0006082_CNS_inflammation1.51044250
48MP0003091_abnormal_cell_migration1.50664577
49MP0005464_abnormal_platelet_physiology1.50366387
50MP0002722_abnormal_immune_system1.50148967
51MP0000689_abnormal_spleen_morphology1.49916357
52MP0002138_abnormal_hepatobiliary_system1.49598915
53MP0004036_abnormal_muscle_relaxation1.45809171
54MP0003045_fibrosis1.44130385
55MP0000465_gastrointestinal_hemorrhage1.42631786
56MP0003453_abnormal_keratinocyte_physiol1.42311209
57MP0002148_abnormal_hypersensitivity_rea1.34927032
58MP0002429_abnormal_blood_cell1.34910691
59MP0001533_abnormal_skeleton_physiology1.34350665
60MP0001845_abnormal_inflammatory_respons1.32355195
61MP0002933_joint_inflammation1.26768904
62MP0000733_abnormal_muscle_development1.26693695
63MP0005023_abnormal_wound_healing1.26125275
64MP0003221_abnormal_cardiomyocyte_apopto1.22910272
65MP0004233_abnormal_muscle_weight1.17228025
66MP0009785_altered_susceptibility_to1.16388371
67MP0002796_impaired_skin_barrier1.16125676
68MP0002877_abnormal_melanocyte_morpholog1.15940668
69MP0002006_tumorigenesis1.15903457
70MP0003172_abnormal_lysosome_physiology1.14863232
71MP0002998_abnormal_bone_remodeling1.13204510
72MP0000759_abnormal_skeletal_muscle1.10239549
73MP0003656_abnormal_erythrocyte_physiolo1.10039483
74MP0003828_pulmonary_edema1.09523841
75MP0003191_abnormal_cellular_cholesterol1.08424506
76MP0004484_altered_response_of1.08397036
77MP0000750_abnormal_muscle_regeneration1.07857535
78MP0003279_aneurysm1.05377594
79MP0005397_hematopoietic_system_phenotyp1.05150253
80MP0001545_abnormal_hematopoietic_system1.05150253
81MP0000015_abnormal_ear_pigmentation1.05049500
82MP0001853_heart_inflammation1.04651781
83MP0000490_abnormal_crypts_of1.03314338
84MP0001216_abnormal_epidermal_layer1.00878255
85MP0005310_abnormal_salivary_gland0.99839194
86MP0005058_abnormal_lysosome_morphology0.97872282
87MP0001849_ear_inflammation0.97777818
88MP0003724_increased_susceptibility_to0.97480336
89MP0003448_altered_tumor_morphology0.97033237
90MP0003868_abnormal_feces_composition0.96824100
91MP0000751_myopathy0.96033154
92MP0000003_abnormal_adipose_tissue0.95898183
93MP0001661_extended_life_span0.95208720
94MP0002060_abnormal_skin_morphology0.94635876
95MP0004381_abnormal_hair_follicle0.93632577
96MP0010630_abnormal_cardiac_muscle0.93054540
97MP0002106_abnormal_muscle_physiology0.92074050
98MP0005621_abnormal_cell_physiology0.90218995
99MP0005623_abnormal_meninges_morphology0.88336271
100MP0001851_eye_inflammation0.88132999
101MP0000747_muscle_weakness0.85748726
102MP0000858_altered_metastatic_potential0.83631016
103MP0008438_abnormal_cutaneous_collagen0.83169053
104MP0009931_abnormal_skin_appearance0.82458466
105MP0000569_abnormal_digit_pigmentation0.81338669
106MP0008469_abnormal_protein_level0.80866804
107MP0002254_reproductive_system_inflammat0.80411152
108MP0010368_abnormal_lymphatic_system0.78240389
109MP0010678_abnormal_skin_adnexa0.76874411
110MP0003183_abnormal_peptide_metabolism0.76871143
111MP0002971_abnormal_brown_adipose0.75732427
112MP0000609_abnormal_liver_physiology0.75269588
113MP0005375_adipose_tissue_phenotype0.74428084
114MP0005501_abnormal_skin_physiology0.73710495
115MP0005390_skeleton_phenotype0.73087120
116MP0000604_amyloidosis0.70840453
117MP0001348_abnormal_lacrimal_gland0.68535762
118MP0005666_abnormal_adipose_tissue0.68465437
119MP0000377_abnormal_hair_follicle0.68324498
120MP0000767_abnormal_smooth_muscle0.68173224
121MP0002925_abnormal_cardiovascular_devel0.66091381
122MP0005174_abnormal_tail_pigmentation0.64149192
123MP0001784_abnormal_fluid_regulation0.62354601
124MP0004087_abnormal_muscle_fiber0.62225489
125MP0001915_intracranial_hemorrhage0.61285913
126MP0008770_decreased_survivor_rate0.60699175
127MP0005083_abnormal_biliary_tract0.60335894

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.37631835
2Nemaline bodies (HP:0003798)3.60901980
3Abnormality of the fingertips (HP:0001211)3.53336531
4Muscle fiber inclusion bodies (HP:0100299)3.45541505
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.41559301
6Spinal cord lesions (HP:0100561)3.41471988
7Syringomyelia (HP:0003396)3.41471988
8Pustule (HP:0200039)3.41023250
9Cellulitis (HP:0100658)3.38985854
10Cerebral aneurysm (HP:0004944)3.38640984
11Recurrent viral infections (HP:0004429)3.30006951
12Recurrent fungal infections (HP:0002841)3.20274710
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.18423302
14Exercise-induced myalgia (HP:0003738)3.15985810
15Increased density of long bones (HP:0006392)3.05400575
16Chronic otitis media (HP:0000389)2.92821041
17Nasal polyposis (HP:0100582)2.92662071
18Inflammation of the large intestine (HP:0002037)2.92203970
19Gastrointestinal inflammation (HP:0004386)2.92030908
20Colitis (HP:0002583)2.90043662
21Spontaneous hematomas (HP:0007420)2.88043745
22IgM deficiency (HP:0002850)2.83276833
23Recurrent abscess formation (HP:0002722)2.76425734
24Recurrent bacterial skin infections (HP:0005406)2.75872003
25Verrucae (HP:0200043)2.72728823
26Papilloma (HP:0012740)2.72728823
27Subacute progressive viral hepatitis (HP:0006572)2.71376642
28Increased IgE level (HP:0003212)2.71249202
29T lymphocytopenia (HP:0005403)2.70781074
30Disproportionate tall stature (HP:0001519)2.70422191
31Centrally nucleated skeletal muscle fibers (HP:0003687)2.68964930
32Stomatitis (HP:0010280)2.68723708
33Panhypogammaglobulinemia (HP:0003139)2.68002348
34Abnormality of the nasal mucosa (HP:0000433)2.54581678
35Autoimmune thrombocytopenia (HP:0001973)2.52431106
36Myocardial infarction (HP:0001658)2.52237757
37Abnormality of T cell number (HP:0011839)2.51256958
38Elevated erythrocyte sedimentation rate (HP:0003565)2.50166377
39Subaortic stenosis (HP:0001682)2.50109880
40Abnormality of the left ventricular outflow tract (HP:0011103)2.50109880
41Mediastinal lymphadenopathy (HP:0100721)2.50052208
42Type 1 muscle fiber predominance (HP:0003803)2.49470634
43Difficulty running (HP:0009046)2.46227780
44Persistence of primary teeth (HP:0006335)2.45745685
45Recurrent bronchitis (HP:0002837)2.41820854
46Broad face (HP:0000283)2.40144672
47EMG: myopathic abnormalities (HP:0003458)2.39822483
48Asymmetry of the thorax (HP:0001555)2.36814755
49Interstitial pulmonary disease (HP:0006530)2.35766679
50Emphysema (HP:0002097)2.30152513
51Shallow orbits (HP:0000586)2.28476732
52Gastrointestinal infarctions (HP:0005244)2.27579048
53Spondylolisthesis (HP:0003302)2.27161802
54Sparse lateral eyebrow (HP:0005338)2.26846065
55Dislocated radial head (HP:0003083)2.26718888
56Round ear (HP:0100830)2.26481434
57Mitral valve prolapse (HP:0001634)2.25198459
58Ragged-red muscle fibers (HP:0003200)2.24869935
59Viral hepatitis (HP:0006562)2.24065994
60Abnormal platelet volume (HP:0011876)2.22673303
61Thick nail (HP:0001805)2.15833374
62Recurrent skin infections (HP:0001581)2.14451988
63Ulnar deviation of the wrist (HP:0003049)2.13417830
64Slow saccadic eye movements (HP:0000514)2.13275349
65Abnormality of skeletal muscle fiber size (HP:0012084)2.12603008
66Hematochezia (HP:0002573)2.12523393
67Ulnar bowing (HP:0003031)2.10673115
68Long eyelashes (HP:0000527)2.10245815
69Leukocytosis (HP:0001974)2.09161470
70Distal upper limb amyotrophy (HP:0007149)2.07381722
71Upper limb amyotrophy (HP:0009129)2.07381722
72Abnormality of the radial head (HP:0003995)2.06982695
73Myositis (HP:0100614)2.06351434
74Combined immunodeficiency (HP:0005387)2.05997946
75Fatigue (HP:0012378)2.04417502
76Abnormality of T cells (HP:0002843)2.04031252
77Chronic mucocutaneous candidiasis (HP:0002728)2.03959112
78Recurrent cutaneous fungal infections (HP:0011370)2.03959112
79Vasculitis (HP:0002633)2.03897677
80Severe combined immunodeficiency (HP:0004430)2.03383410
81Distal lower limb amyotrophy (HP:0008944)2.03271797
82Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.01010016
83Urethral obstruction (HP:0000796)2.00984247
84Axonal loss (HP:0003447)2.00469638
85Agammaglobulinemia (HP:0004432)2.00031439
86Autoimmune hemolytic anemia (HP:0001890)1.99723079
87Distal lower limb muscle weakness (HP:0009053)1.97983479
88Chest pain (HP:0100749)1.97700711
89Frequent falls (HP:0002359)1.97495386
90Meningitis (HP:0001287)1.97084881
91Increased variability in muscle fiber diameter (HP:0003557)1.96546723
92Aortic aneurysm (HP:0004942)1.96538097
93Dilatation of the ascending aorta (HP:0005111)1.96518296
94Thyroiditis (HP:0100646)1.95831769
95Aneurysm (HP:0002617)1.95685981
96Abnormality of liposaccharide metabolism (HP:0010968)1.94994836
97Abnormality of glycosphingolipid metabolism (HP:0004343)1.94994836
98Abnormality of glycolipid metabolism (HP:0010969)1.94994836
99Gastrointestinal stroma tumor (HP:0100723)1.94150641
100Macroorchidism (HP:0000053)1.93867374
101Peritonitis (HP:0002586)1.92752360
102Lower limb amyotrophy (HP:0007210)1.91832887
103Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.89554930
104Vertebral arch anomaly (HP:0008438)1.88365254
105Mitral stenosis (HP:0001718)1.88189552
106Increased mean platelet volume (HP:0011877)1.87720032
107Increased CSF protein (HP:0002922)1.87465368
108Eosinophilia (HP:0001880)1.87267329
109Thoracic kyphosis (HP:0002942)1.85281882
110Abnormality of the thoracic spine (HP:0100711)1.84566421
111Abnormality of eosinophils (HP:0001879)1.84336613
112Increased connective tissue (HP:0009025)1.82875899
113Gingivitis (HP:0000230)1.82430146
114Micronodular cirrhosis (HP:0001413)1.81991862
115Truncal obesity (HP:0001956)1.81483122
116Dysostosis multiplex (HP:0000943)1.81337514
117Periodontitis (HP:0000704)1.80790045
118Osteomyelitis (HP:0002754)1.80699649
119Lymphopenia (HP:0001888)1.80347262
120Sepsis (HP:0100806)1.79870493
121Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79766938
122Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79766938
123Abnormality of polysaccharide metabolism (HP:0011012)1.79766938
124Osteolytic defects of the phalanges of the hand (HP:0009771)1.79433365
125Osteolytic defects of the hand bones (HP:0009699)1.79433365
126Prolonged bleeding time (HP:0003010)1.76239170
127Dysmetric saccades (HP:0000641)1.75775117
128Abnormality of cells of the lymphoid lineage (HP:0012140)1.73740412
129Distal arthrogryposis (HP:0005684)1.71582365
130Thrombocytosis (HP:0001894)1.71413991
131Progressive muscle weakness (HP:0003323)1.70887790
132Abnormality of macrophages (HP:0004311)1.70809523
133Mucopolysacchariduria (HP:0008155)1.70595321
134Urinary glycosaminoglycan excretion (HP:0003541)1.70595321
135Neck muscle weakness (HP:0000467)1.70579741
136Lip pit (HP:0100267)1.70421000
137Arterial tortuosity (HP:0005116)1.70175090
138Abnormality of T cell physiology (HP:0011840)1.69244349
139Bicuspid aortic valve (HP:0001647)1.67438813
140Obstructive sleep apnea (HP:0002870)1.67040467
141Termporal pattern (HP:0011008)1.65917279
142Insidious onset (HP:0003587)1.65917279
143Thoracolumbar scoliosis (HP:0002944)1.65829327
144Exocrine pancreatic insufficiency (HP:0001738)1.65717502
145Skin ulcer (HP:0200042)1.65583800
146Genu recurvatum (HP:0002816)1.65581387
147Prominent nose (HP:0000448)1.65425373
148Asymmetric septal hypertrophy (HP:0001670)1.65314067
149Hepatitis (HP:0012115)1.64155961
150Hyperacusis (HP:0010780)1.63268803
151Long palpebral fissure (HP:0000637)1.62856042
152Mitral regurgitation (HP:0001653)1.62809918
153Basal cell carcinoma (HP:0002671)1.62664891
154Acrocyanosis (HP:0001063)1.62410651
155Hyporeflexia of lower limbs (HP:0002600)1.61795475
156IgA deficiency (HP:0002720)1.61678878
157Absent frontal sinuses (HP:0002688)1.60272455
158Germ cell neoplasia (HP:0100728)1.60144114

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.62305192
2PRPF4B3.92936922
3EEF2K3.76079387
4MAP3K103.58492350
5ERN13.22302990
6TRIB32.87116033
7TIE12.42061717
8EPHB12.27882007
9CDK122.22825354
10PKN22.22320212
11SMG12.03880215
12STK102.01745657
13CSF1R2.01250212
14JAK31.98743119
15FGFR41.88885844
16SIK11.88875322
17TYK21.87631595
18OBSCN1.73768875
19GRK61.70607333
20CDK61.67787585
21DMPK1.62575276
22TTN1.59738694
23ZAP701.58538497
24LRRK21.51054540
25PTK61.49519435
26TBK11.43109149
27HCK1.42202711
28ICK1.41784331
29MAP3K131.35459878
30RIPK11.35151574
31MAPK121.35035221
32JAK11.32910933
33ITK1.30406977
34PRKD31.28655839
35MAP3K141.28236322
36BMX1.25970800
37PIK3CG1.25968722
38NEK91.24764971
39CHUK1.22970274
40CLK11.22912033
41SIK21.21289491
42TAOK11.20841656
43TEC1.20520956
44CSK1.18921416
45IKBKB1.18449202
46EPHA31.14574270
47BLK1.13343067
48BTK1.13032828
49HIPK21.11307920
50BMPR21.08715996
51LCK1.08093805
52SYK1.05756009
53MARK21.04929260
54TGFBR21.03756338
55TXK1.03182225
56MAP3K21.03158288
57MARK31.02433545
58PASK1.01612353
59PDK21.00738254
60MTOR0.99266446
61PIM10.97655707
62STK30.97506666
63MAPK110.97495263
64IKBKE0.96460983
65SGK30.95579456
66AKT30.94035178
67MAP3K70.92910505
68PRKCH0.92526005
69NLK0.90414580
70IRAK40.88929467
71TAOK30.86852561
72FGFR30.86801999
73MAP3K110.85742077
74SGK20.85650078
75MAP2K30.84320592
76LMTK20.83542415
77ALK0.80734361
78NME20.78942238
79RPS6KA60.78915982
80JAK20.76962327
81RPS6KA40.76168854
82MAP3K30.75760520
83IRAK30.75281430
84RPS6KC10.73530693
85RPS6KL10.73530693
86BRD40.73436925
87CAMK1D0.71964668
88STK40.68213903
89PDPK10.67685221
90PRKD20.67183650
91PDGFRB0.67112670
92FES0.66740944
93EIF2AK30.66089033
94TRPM70.65084450
95MAP3K60.64201670
96MELK0.62855769
97NEK60.62236134
98MOS0.60806409
99STK110.60748864
100MST1R0.59554221
101RIPK40.57909868
102TYRO30.57211118
103CAMK1G0.56775593
104CDC42BPA0.55669234
105PDGFRA0.55578762
106MAPK40.55493108
107SIK30.54961656
108NUAK10.54392003
109RPS6KA20.53997051
110MAP3K10.52810830
111RPS6KA10.52782903
112PRKCQ0.51965223
113KIT0.51888600
114PAK20.51344683
115WNK10.50104089
116STK380.49531067
117CCNB10.47656943
118TAOK20.46725243
119MAPK70.46627699
120PTK20.46569606
121IRAK20.46124131
122CAMKK20.46028119
123CDK90.44249340
124RPS6KB10.43617705
125CDK40.43430716
126DYRK1B0.43383486
127YES10.43365065
128RPS6KA50.42662896
129MAP3K80.42525894
130PKN10.42481025
131MAPKAPK20.42083343
132PRKD10.41356506
133TNK20.41080486
134INSR0.39392167
135LYN0.39185775
136RET0.37919842
137MAP2K20.36638083
138SCYL20.36604648
139PDK10.36224189

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.79975863
2B cell receptor signaling pathway_Homo sapiens_hsa046622.63321305
3Osteoclast differentiation_Homo sapiens_hsa043802.43811309
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.21680408
5Leishmaniasis_Homo sapiens_hsa051402.16065631
6T cell receptor signaling pathway_Homo sapiens_hsa046602.11769399
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.07353572
8Chronic myeloid leukemia_Homo sapiens_hsa052202.03992500
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.02037418
10Acute myeloid leukemia_Homo sapiens_hsa052211.90644005
11Measles_Homo sapiens_hsa051621.75306839
12Toxoplasmosis_Homo sapiens_hsa051451.68548371
13Jak-STAT signaling pathway_Homo sapiens_hsa046301.57946573
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.50143888
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.50095229
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.49782514
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44767640
18Notch signaling pathway_Homo sapiens_hsa043301.40741261
19Viral myocarditis_Homo sapiens_hsa054161.39366513
20Antigen processing and presentation_Homo sapiens_hsa046121.37388649
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.36606257
22Pancreatic cancer_Homo sapiens_hsa052121.35406051
23Chemokine signaling pathway_Homo sapiens_hsa040621.32475252
24TNF signaling pathway_Homo sapiens_hsa046681.32165446
25Hepatitis B_Homo sapiens_hsa051611.31680868
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30186485
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28480657
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27685264
29Platelet activation_Homo sapiens_hsa046111.26491543
30Lysine degradation_Homo sapiens_hsa003101.25648543
31Insulin resistance_Homo sapiens_hsa049311.25520056
32Hematopoietic cell lineage_Homo sapiens_hsa046401.25434675
33Type II diabetes mellitus_Homo sapiens_hsa049301.21619219
34Small cell lung cancer_Homo sapiens_hsa052221.21482220
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19852230
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.19080742
37Renal cell carcinoma_Homo sapiens_hsa052111.16777419
38Prolactin signaling pathway_Homo sapiens_hsa049171.14987397
39Apoptosis_Homo sapiens_hsa042101.14599160
40Viral carcinogenesis_Homo sapiens_hsa052031.14573965
41Thyroid cancer_Homo sapiens_hsa052161.13271485
42Adipocytokine signaling pathway_Homo sapiens_hsa049201.12971667
43Non-small cell lung cancer_Homo sapiens_hsa052231.12848283
44mTOR signaling pathway_Homo sapiens_hsa041501.11442350
45HTLV-I infection_Homo sapiens_hsa051661.10511003
46Staphylococcus aureus infection_Homo sapiens_hsa051501.09796463
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08746872
48Malaria_Homo sapiens_hsa051441.08376484
49Proteoglycans in cancer_Homo sapiens_hsa052051.07945372
50Influenza A_Homo sapiens_hsa051641.06118900
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05958902
52Herpes simplex infection_Homo sapiens_hsa051681.05823266
53VEGF signaling pathway_Homo sapiens_hsa043701.05135628
54Amoebiasis_Homo sapiens_hsa051461.01550740
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99703961
56Type I diabetes mellitus_Homo sapiens_hsa049400.99340769
57Tuberculosis_Homo sapiens_hsa051520.98637827
58Graft-versus-host disease_Homo sapiens_hsa053320.96913192
59Circadian rhythm_Homo sapiens_hsa047100.95070614
60MicroRNAs in cancer_Homo sapiens_hsa052060.94809561
61Adherens junction_Homo sapiens_hsa045200.94545267
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94502530
63GnRH signaling pathway_Homo sapiens_hsa049120.93838963
64Autoimmune thyroid disease_Homo sapiens_hsa053200.93427363
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92940215
66Legionellosis_Homo sapiens_hsa051340.92323218
67Shigellosis_Homo sapiens_hsa051310.90199200
68Salmonella infection_Homo sapiens_hsa051320.90086832
69Choline metabolism in cancer_Homo sapiens_hsa052310.89458845
70Pertussis_Homo sapiens_hsa051330.89362400
71Focal adhesion_Homo sapiens_hsa045100.85315421
72Allograft rejection_Homo sapiens_hsa053300.82474941
73MAPK signaling pathway_Homo sapiens_hsa040100.82217640
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79823672
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79241366
76Dorso-ventral axis formation_Homo sapiens_hsa043200.78705176
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76371751
78Hepatitis C_Homo sapiens_hsa051600.75992786
79Prostate cancer_Homo sapiens_hsa052150.75892695
80Bladder cancer_Homo sapiens_hsa052190.75845586
81Colorectal cancer_Homo sapiens_hsa052100.74416964
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74321515
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72061363
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71875793
85AMPK signaling pathway_Homo sapiens_hsa041520.71813213
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.70966022
87Endometrial cancer_Homo sapiens_hsa052130.70591704
88Long-term potentiation_Homo sapiens_hsa047200.69875726
89HIF-1 signaling pathway_Homo sapiens_hsa040660.66709876
90FoxO signaling pathway_Homo sapiens_hsa040680.66262939
91Endocytosis_Homo sapiens_hsa041440.66017617
92ABC transporters_Homo sapiens_hsa020100.65634860
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65227042
94Dilated cardiomyopathy_Homo sapiens_hsa054140.64620018
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.64184398
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.64135720
97Regulation of autophagy_Homo sapiens_hsa041400.63016945
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62742085
99Inositol phosphate metabolism_Homo sapiens_hsa005620.61197402
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60431707
101Estrogen signaling pathway_Homo sapiens_hsa049150.59878379
102Rap1 signaling pathway_Homo sapiens_hsa040150.59530096
103Glioma_Homo sapiens_hsa052140.58840413
104Epstein-Barr virus infection_Homo sapiens_hsa051690.58809888
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58337254
106Pathways in cancer_Homo sapiens_hsa052000.57950988
107ErbB signaling pathway_Homo sapiens_hsa040120.55669089
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55303613
109Systemic lupus erythematosus_Homo sapiens_hsa053220.55035292
110Lysosome_Homo sapiens_hsa041420.54214859
111Glucagon signaling pathway_Homo sapiens_hsa049220.54146062
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51470753
113Other glycan degradation_Homo sapiens_hsa005110.47490016
114Insulin signaling pathway_Homo sapiens_hsa049100.46705569
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.44623037

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