ZXDC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.21076255
2response to muramyl dipeptide (GO:0032495)4.41783628
3positive regulation of gamma-delta T cell activation (GO:0046645)4.37090161
4response to peptidoglycan (GO:0032494)4.17920667
5detection of other organism (GO:0098543)4.14524346
6detection of bacterium (GO:0016045)4.02276016
7leukocyte aggregation (GO:0070486)3.98375547
8fibroblast migration (GO:0010761)3.87772187
9positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.81957637
10regulation of gamma-delta T cell activation (GO:0046643)3.78419529
11regulation of gamma-delta T cell differentiation (GO:0045586)3.76749587
12regulation of interleukin-12 biosynthetic process (GO:0045075)3.69193009
13antigen processing and presentation of endogenous antigen (GO:0019883)3.68932349
14cytoplasmic mRNA processing body assembly (GO:0033962)3.67139791
15macrophage activation involved in immune response (GO:0002281)3.63392564
16detection of external biotic stimulus (GO:0098581)3.61909399
17B cell receptor signaling pathway (GO:0050853)3.56073106
18megakaryocyte development (GO:0035855)3.48242400
19growth hormone receptor signaling pathway (GO:0060396)3.44972625
20regulation of necroptotic process (GO:0060544)3.41890440
21positive regulation of p38MAPK cascade (GO:1900745)3.35163599
22immunoglobulin mediated immune response (GO:0016064)3.32863512
23thymic T cell selection (GO:0045061)3.25709171
24detection of biotic stimulus (GO:0009595)3.20656557
25T cell selection (GO:0045058)3.20610329
26neutrophil activation involved in immune response (GO:0002283)3.18218382
27erythrocyte maturation (GO:0043249)3.13402694
28positive regulation of Rap GTPase activity (GO:0032854)3.13239828
29negative thymic T cell selection (GO:0045060)3.12417071
30detection of molecule of bacterial origin (GO:0032490)3.10492299
31negative regulation of interleukin-12 production (GO:0032695)3.10344817
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.07502229
33response to host immune response (GO:0052572)3.07502229
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.06731758
35response to host (GO:0075136)3.05935991
36response to host defenses (GO:0052200)3.05935991
37response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.05935991
38negative regulation of lymphocyte mediated immunity (GO:0002707)3.04063909
39positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.01194947
40germinal center formation (GO:0002467)3.01134474
41negative T cell selection (GO:0043383)2.99092594
42definitive hemopoiesis (GO:0060216)2.96922639
43positive regulation of natural killer cell differentiation (GO:0032825)2.96386908
44regulation of p38MAPK cascade (GO:1900744)2.95233655
45positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.93432027
46regulation of interferon-beta biosynthetic process (GO:0045357)2.90608569
47antigen processing and presentation via MHC class Ib (GO:0002475)2.89164809
48embryonic process involved in female pregnancy (GO:0060136)2.88716088
49positive thymic T cell selection (GO:0045059)2.87888876
50cellular response to growth hormone stimulus (GO:0071378)2.84485451
51negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.82398520
52negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.81157162
53positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.78972633
54regulation of monocyte differentiation (GO:0045655)2.77962033
55regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.77572225
56negative regulation of T cell mediated immunity (GO:0002710)2.76651478
57negative regulation of leukocyte mediated immunity (GO:0002704)2.74986864
58mannose metabolic process (GO:0006013)2.74804782
59negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.74215311
60positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.74100082
61regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.74100082
62insulin-like growth factor receptor signaling pathway (GO:0048009)2.72872386
63regulation of cholesterol storage (GO:0010885)2.71802836
64regulation of granulocyte differentiation (GO:0030852)2.70451601
65cellular response to virus (GO:0098586)2.70045136
66positive regulation of histone deacetylation (GO:0031065)2.69626015
67neutrophil mediated immunity (GO:0002446)2.67260404
68substrate-dependent cell migration (GO:0006929)2.66368880
69macrophage activation (GO:0042116)2.66240132
70positive regulation of granulocyte differentiation (GO:0030854)2.65093479
71positive regulation of interferon-alpha production (GO:0032727)2.64346615
72regulation of leukocyte degranulation (GO:0043300)2.63614470
73histone H3-K4 methylation (GO:0051568)2.63108825
74negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.62895410
75negative regulation of cell killing (GO:0031342)2.62895410
76histone H3-K36 demethylation (GO:0070544)2.62547395
77response to interleukin-15 (GO:0070672)2.62052727
78histone H4-K12 acetylation (GO:0043983)2.61285434
79negative regulation of myotube differentiation (GO:0010832)2.60098398
80regulation of NFAT protein import into nucleus (GO:0051532)2.59307671
81regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.58647059
82negative regulation of necroptotic process (GO:0060546)2.58164066
83negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.57477032
84negative regulation of T-helper cell differentiation (GO:0045623)2.57477032
85myeloid cell activation involved in immune response (GO:0002275)2.56456322
86viral entry into host cell (GO:0046718)2.55763746
87regulation of ARF protein signal transduction (GO:0032012)2.55510413
88embryonic placenta development (GO:0001892)2.55397630
89positive regulation of B cell differentiation (GO:0045579)2.54748280
90histone demethylation (GO:0016577)2.54553191
91regulation of myeloid leukocyte mediated immunity (GO:0002886)2.53718965
92negative regulation of toll-like receptor signaling pathway (GO:0034122)2.53357598
93hepatocyte apoptotic process (GO:0097284)2.52805318
94macroautophagy (GO:0016236)2.52626585
95cellular response to fluid shear stress (GO:0071498)2.52598193
96regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.52374343
97regulation of Rap GTPase activity (GO:0032317)2.52074133
98cellular hyperosmotic response (GO:0071474)2.51903773
99positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.51432578
100regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.51432578
101histone lysine demethylation (GO:0070076)2.51001674
102melanin biosynthetic process (GO:0042438)2.50852431
103T cell migration (GO:0072678)2.49911609
104regulation of B cell differentiation (GO:0045577)2.49779709
1053-UTR-mediated mRNA stabilization (GO:0070935)2.49455004
106regulation of mast cell degranulation (GO:0043304)2.48955450
107negative regulation of interleukin-6 production (GO:0032715)2.47960974
108respiratory burst (GO:0045730)2.47811699
109microglial cell activation (GO:0001774)2.46252808
110histone H4 deacetylation (GO:0070933)2.44959438
111tolerance induction (GO:0002507)2.44275478
112positive T cell selection (GO:0043368)2.44248534
113regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.43569380
114positive regulation of cellular amide metabolic process (GO:0034250)2.43167353
115neutrophil activation (GO:0042119)2.42879268
116negative regulation of lipid storage (GO:0010888)2.42415609
117regulation of T-helper 2 cell differentiation (GO:0045628)2.42000185
118interleukin-1-mediated signaling pathway (GO:0070498)2.41673039
119interferon-gamma production (GO:0032609)2.40021758
120low-density lipoprotein particle clearance (GO:0034383)2.38534060
121platelet dense granule organization (GO:0060155)2.38249763
122negative regulation of erythrocyte differentiation (GO:0045647)2.37514394
123positive regulation of humoral immune response (GO:0002922)2.35757192
124positive regulation of mRNA catabolic process (GO:0061014)2.35605755
125establishment of protein localization to Golgi (GO:0072600)2.33697676
126positive regulation of hormone biosynthetic process (GO:0046886)2.32850275
127receptor guanylyl cyclase signaling pathway (GO:0007168)2.32665074
128myeloid dendritic cell differentiation (GO:0043011)2.32385889
129regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.31404216
130phospholipid homeostasis (GO:0055091)2.29735097
131phosphatidylinositol dephosphorylation (GO:0046856)2.29669709
132response to laminar fluid shear stress (GO:0034616)2.28492830
133protein dealkylation (GO:0008214)2.27802137
134protein demethylation (GO:0006482)2.27802137
135negative regulation of granulocyte differentiation (GO:0030853)2.27330064
136antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.27049949
137antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.27049949
138regulation of B cell receptor signaling pathway (GO:0050855)2.25928780
139embryonic hemopoiesis (GO:0035162)2.25564472
140positive regulation of respiratory burst (GO:0060267)2.25353232
141pericardium development (GO:0060039)2.24943387
142Arp2/3 complex-mediated actin nucleation (GO:0034314)2.23817884
143regulation of alkaline phosphatase activity (GO:0010692)2.20206366
144regulation of natural killer cell differentiation (GO:0032823)2.20057732
145apoptotic cell clearance (GO:0043277)2.19008997
146tyrosine phosphorylation of STAT protein (GO:0007260)2.18911369
147melanin metabolic process (GO:0006582)2.18621601
148regulation of T cell tolerance induction (GO:0002664)2.17671853
149platelet formation (GO:0030220)2.17012954
150platelet-derived growth factor receptor signaling pathway (GO:0048008)2.16609968
151phospholipid dephosphorylation (GO:0046839)2.16297380
152protein localization to endosome (GO:0036010)2.16275560
153JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.15301290
154positive regulation of triglyceride biosynthetic process (GO:0010867)2.14865289
155secretory granule organization (GO:0033363)2.14454236
156cellular extravasation (GO:0045123)2.13780375
157I-kappaB phosphorylation (GO:0007252)2.12982586
158production of molecular mediator involved in inflammatory response (GO:0002532)2.12778834
159positive regulation by symbiont of host defense response (GO:0052509)2.10674805
160modulation by symbiont of host defense response (GO:0052031)2.10674805
161modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.10674805
162modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.10674805
163positive regulation by organism of defense response of other organism involved in symbiotic interact2.10674805
164modulation by symbiont of host immune response (GO:0052553)2.10674805
165nerve growth factor signaling pathway (GO:0038180)2.10068860
166nodal signaling pathway (GO:0038092)2.09715414
167NLS-bearing protein import into nucleus (GO:0006607)2.09217461
168NIK/NF-kappaB signaling (GO:0038061)2.08658914
169phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.08265759
170positive regulation of cardiac muscle cell differentiation (GO:2000727)2.07988404
171histone H3-K9 demethylation (GO:0033169)2.06479542
172Rap protein signal transduction (GO:0032486)2.05383736

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.75685098
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.68497252
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.38623086
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.24547305
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.11244680
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.06006185
7SCL_19346495_ChIP-Seq_HPC-7_Human2.88180993
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.41676143
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.30995503
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29364503
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.27430249
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.21034321
13* GATA2_21666600_ChIP-Seq_HMVEC_Human2.20791433
14TCF7_22412390_ChIP-Seq_EML_Mouse2.20414952
15RUNX_20019798_ChIP-Seq_JUKART_Human2.19345393
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.15366846
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10570637
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.01776305
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00601339
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.98102733
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.96935850
22LXR_22292898_ChIP-Seq_THP-1_Human1.95712326
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.89673442
24GATA1_22025678_ChIP-Seq_K562_Human1.86267871
25MYC_22102868_ChIP-Seq_BL_Human1.85263510
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84149458
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80981668
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.80973157
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.79443410
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75384142
31MAF_26560356_Chip-Seq_TH2_Human1.73773799
32SPI1_23127762_ChIP-Seq_K562_Human1.72493621
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69440298
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68393576
35GATA1_19941826_ChIP-Seq_K562_Human1.67524576
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.67390572
37SPI1_23547873_ChIP-Seq_NB4_Human1.58738001
38* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56593316
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54328170
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52529438
41RACK7_27058665_Chip-Seq_MCF-7_Human1.51689313
42DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.51441163
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49941229
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.48103092
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46517376
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43722516
47* VDR_21846776_ChIP-Seq_THP-1_Human1.42419239
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40899948
49MAF_26560356_Chip-Seq_TH1_Human1.37687202
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.36112393
51SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35998589
52FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.34679704
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34579157
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34456813
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.33734609
56GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31050510
57KDM2B_26808549_Chip-Seq_DND41_Human1.30796895
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27537879
59RXR_22108803_ChIP-Seq_LS180_Human1.27317341
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26403418
61* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25866529
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25762469
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25273181
64CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24396766
65RUNX1_27514584_Chip-Seq_MCF-7_Human1.23618920
66* VDR_24763502_ChIP-Seq_THP-1_Human1.23077668
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22783410
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21945338
69* KDM2B_26808549_Chip-Seq_K562_Human1.21298951
70PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21227010
71IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.21193105
72SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19927240
73SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19927240
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.19193354
75AHR_22903824_ChIP-Seq_MCF-7_Human1.18516120
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18325167
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17233418
78* GATA2_19941826_ChIP-Seq_K562_Human1.16056096
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15332052
80PU_27001747_Chip-Seq_BMDM_Mouse1.14755325
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13772433
82RUNX1_22412390_ChIP-Seq_EML_Mouse1.13115489
83ESR1_20079471_ChIP-ChIP_T-47D_Human1.12252823
84SMC4_20622854_ChIP-Seq_HELA_Human1.11983217
85FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11795007
86* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10837468
87PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10835445
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10679632
89BRD4_25478319_ChIP-Seq_HGPS_Human1.10655030
90DROSHA_22980978_ChIP-Seq_HELA_Human1.10628820
91GATA1_19941827_ChIP-Seq_MEL_Mouse1.10526873
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09876683
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09770372
94GATA3_27048872_Chip-Seq_THYMUS_Human1.09471396
95VDR_24787735_ChIP-Seq_THP-1_Human1.09407478
96TP53_16413492_ChIP-PET_HCT116_Human1.09374114
97MYB_26560356_Chip-Seq_TH2_Human1.08985934
98CIITA_25753668_ChIP-Seq_RAJI_Human1.08809437
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07592423
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07565595
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06542011
102MYB_26560356_Chip-Seq_TH1_Human1.06317718
103UTX_26944678_Chip-Seq_JUKART_Human1.05403279
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05141678
105NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05141678
106CREB1_26743006_Chip-Seq_LNCaP_Human1.04975914
107P68_20966046_ChIP-Seq_HELA_Human1.04503638
108SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04132659
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03339300
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01431254
111CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01162837
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01151640
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00870682
114PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00301724
115NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99748699
116* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99638050
117SA1_27219007_Chip-Seq_ERYTHROID_Human0.99520203
118TBX20_22328084_ChIP-Seq_HEART_Mouse0.99428717
119TBX20_22080862_ChIP-Seq_HEART_Mouse0.99428717
120GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99322845
121LXR_22158963_ChIP-Seq_LIVER_Mouse0.98920737
122CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98578675
123IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98567975
124* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98508377
125* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97692557
126RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97375106
127BCOR_27268052_Chip-Seq_Bcells_Human0.97368575
128TP63_17297297_ChIP-ChIP_HaCaT_Human0.97166147
129CLOCK_20551151_ChIP-Seq_293T_Human0.96852087
130PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96602569
131SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95332060
132ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95144565
133FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95101672
134P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93262634
135MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93119529
136FOXA2_19822575_ChIP-Seq_HepG2_Human0.92986230
137* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92932418
138WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92591846
139NCOR1_26117541_ChIP-Seq_K562_Human0.92495342

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.17758592
2MP0002877_abnormal_melanocyte_morpholog3.92808380
3MP0009278_abnormal_bone_marrow3.23063745
4MP0003279_aneurysm3.05298335
5MP0003724_increased_susceptibility_to2.70858074
6MP0000371_diluted_coat_color2.65168739
7MP0003191_abnormal_cellular_cholesterol2.42679692
8MP0005451_abnormal_body_composition2.42473273
9MP0004510_myositis2.35866293
10MP0005409_darkened_coat_color2.31630866
11MP0003300_gastrointestinal_ulcer2.28484638
12MP0002089_abnormal_postnatal_growth/wei2.19673280
13MP0005076_abnormal_cell_differentiation2.17731199
14MP0005257_abnormal_intraocular_pressure2.16191905
15MP0002254_reproductive_system_inflammat2.09570584
16MP0003172_abnormal_lysosome_physiology2.04651764
17MP0004381_abnormal_hair_follicle1.99884853
18MP0005397_hematopoietic_system_phenotyp1.99514357
19MP0001545_abnormal_hematopoietic_system1.99514357
20MP0009780_abnormal_chondrocyte_physiolo1.98102436
21MP0004808_abnormal_hematopoietic_stem1.97981283
22MP0003705_abnormal_hypodermis_morpholog1.95855982
23MP0008260_abnormal_autophagy1.95678264
24MP0008961_abnormal_basal_metabolism1.93951166
25MP0005174_abnormal_tail_pigmentation1.90446936
26MP0003303_peritoneal_inflammation1.86839145
27MP0002009_preneoplasia1.84136355
28MP0003943_abnormal_hepatobiliary_system1.81900014
29MP0003566_abnormal_cell_adhesion1.80429805
30MP0003436_decreased_susceptibility_to1.67900639
31MP0009384_cardiac_valve_regurgitation1.65667047
32MP0008057_abnormal_DNA_replication1.62236218
33MP0002405_respiratory_system_inflammati1.58693254
34MP0010352_gastrointestinal_tract_polyps1.58184164
35MP0001324_abnormal_eye_pigmentation1.57415703
36MP0000685_abnormal_immune_system1.57390067
37MP0000015_abnormal_ear_pigmentation1.56923811
38MP0005464_abnormal_platelet_physiology1.56469085
39MP0010368_abnormal_lymphatic_system1.55155704
40MP0004185_abnormal_adipocyte_glucose1.54987452
41MP0003091_abnormal_cell_migration1.53109605
42MP0009333_abnormal_splenocyte_physiolog1.47029755
43MP0003045_fibrosis1.46300441
44MP0005666_abnormal_adipose_tissue1.45319580
45MP0000767_abnormal_smooth_muscle1.44346938
46MP0009785_altered_susceptibility_to1.41226913
47MP0003656_abnormal_erythrocyte_physiolo1.41066004
48MP0002429_abnormal_blood_cell1.31871181
49MP0005171_absent_coat_pigmentation1.31056484
50MP0001879_abnormal_lymphatic_vessel1.30422289
51MP0005671_abnormal_response_to1.29897088
52MP0002075_abnormal_coat/hair_pigmentati1.29296877
53MP0005058_abnormal_lysosome_morphology1.28736973
54MP0002148_abnormal_hypersensitivity_rea1.28221435
55MP0004130_abnormal_muscle_cell1.25958769
56MP0006082_CNS_inflammation1.25872323
57MP0001845_abnormal_inflammatory_respons1.24884014
58MP0002419_abnormal_innate_immunity1.23798122
59MP0000372_irregular_coat_pigmentation1.23509054
60MP0002452_abnormal_antigen_presenting1.23351935
61MP0003183_abnormal_peptide_metabolism1.22757763
62MP0005387_immune_system_phenotype1.22518264
63MP0001790_abnormal_immune_system1.22518264
64MP0005310_abnormal_salivary_gland1.22232604
65MP0001851_eye_inflammation1.21963842
66MP0005167_abnormal_blood-brain_barrier1.21056413
67MP0001270_distended_abdomen1.18639554
68MP0003453_abnormal_keratinocyte_physiol1.18376246
69MP0006054_spinal_hemorrhage1.17985430
70MP0001915_intracranial_hemorrhage1.16023946
71MP0001835_abnormal_antigen_presentation1.16014475
72MP0003828_pulmonary_edema1.15923839
73MP0002928_abnormal_bile_duct1.15337049
74MP0001800_abnormal_humoral_immune1.13670824
75MP0010234_abnormal_vibrissa_follicle1.13553538
76MP0004947_skin_inflammation1.13394712
77MP0002132_abnormal_respiratory_system1.12715785
78MP0003646_muscle_fatigue1.11844907
79MP0003252_abnormal_bile_duct1.10766569
80MP0002166_altered_tumor_susceptibility1.10762201
81MP0005670_abnormal_white_adipose1.10577190
82MP0008469_abnormal_protein_level1.09842862
83MP0002420_abnormal_adaptive_immunity1.06597099
84MP0001819_abnormal_immune_cell1.06155449
85MP0002398_abnormal_bone_marrow1.05621869
86MP0000733_abnormal_muscle_development1.03668060
87MP0002998_abnormal_bone_remodeling1.03045188
88MP0002723_abnormal_immune_serum1.02605258
89MP0005375_adipose_tissue_phenotype1.00728772
90MP0002396_abnormal_hematopoietic_system1.00554543
91MP0010155_abnormal_intestine_physiology1.00165343
92MP0003866_abnormal_defecation1.00100986
93MP0004264_abnormal_extraembryonic_tissu0.98322919
94MP0002138_abnormal_hepatobiliary_system0.96307137
95MP0003763_abnormal_thymus_physiology0.95733780
96MP0004036_abnormal_muscle_relaxation0.95665928
97MP0004233_abnormal_muscle_weight0.94135932
98MP0009115_abnormal_fat_cell0.93153711
99MP0003950_abnormal_plasma_membrane0.93091984
100MP0001186_pigmentation_phenotype0.92863443
101MP0010630_abnormal_cardiac_muscle0.91399512
102MP0005075_abnormal_melanosome_morpholog0.90699133
103MP0000703_abnormal_thymus_morphology0.90616533
104MP0002095_abnormal_skin_pigmentation0.90490284
105MP0001873_stomach_inflammation0.89260257
106MP0002896_abnormal_bone_mineralization0.89050217
107MP0005164_abnormal_response_to0.88588772
108MP0000516_abnormal_urinary_system0.87756941
109MP0005367_renal/urinary_system_phenotyp0.87756941
110MP0010307_abnormal_tumor_latency0.87742513
111MP0002090_abnormal_vision0.87078364
112MP0003868_abnormal_feces_composition0.86638360
113MP0003221_abnormal_cardiomyocyte_apopto0.86202301
114MP0002006_tumorigenesis0.84629010
115MP0003690_abnormal_glial_cell0.84621370
116MP0009764_decreased_sensitivity_to0.84535227
117MP0001986_abnormal_taste_sensitivity0.84206802
118MP0001533_abnormal_skeleton_physiology0.83678036
119MP0002933_joint_inflammation0.82876270
120MP0002128_abnormal_blood_circulation0.81870465
121MP0002722_abnormal_immune_system0.81644313
122MP0005000_abnormal_immune_tolerance0.80830892
123MP0001853_heart_inflammation0.80703076
124MP0000249_abnormal_blood_vessel0.80177031
125MP0000465_gastrointestinal_hemorrhage0.80006673
126MP0004883_abnormal_blood_vessel0.79964395
127MP0002971_abnormal_brown_adipose0.79923533
128MP0000490_abnormal_crypts_of0.79731623
129MP0009840_abnormal_foam_cell0.79608233
130MP0000716_abnormal_immune_system0.77661608
131MP0005621_abnormal_cell_physiology0.76217543
132MP0000689_abnormal_spleen_morphology0.76177445
133MP0008775_abnormal_heart_ventricle0.76129657
134MP0005025_abnormal_response_to0.75353316
135MP0003795_abnormal_bone_structure0.75008047
136MP0005023_abnormal_wound_healing0.74438369
137MP0005408_hypopigmentation0.74295784
138MP0005166_decreased_susceptibility_to0.73721619
139MP0000858_altered_metastatic_potential0.72336822
140MP0004087_abnormal_muscle_fiber0.71397528
141MP0002970_abnormal_white_adipose0.70729859

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.98503177
2Vertebral arch anomaly (HP:0008438)3.80976166
3Broad metatarsal (HP:0001783)3.63265056
4Colitis (HP:0002583)3.46587305
5Spontaneous hematomas (HP:0007420)3.38530384
6Mesomelia (HP:0003027)3.27261373
7Macroorchidism (HP:0000053)3.12901025
8Radial bowing (HP:0002986)3.11635206
9Meningitis (HP:0001287)2.99572335
10Cerebral aneurysm (HP:0004944)2.97459889
11Spinal cord lesions (HP:0100561)2.96687285
12Syringomyelia (HP:0003396)2.96687285
13Mediastinal lymphadenopathy (HP:0100721)2.95981855
14Abnormality of macrophages (HP:0004311)2.93555616
15Gastrointestinal inflammation (HP:0004386)2.92073050
16Chronic mucocutaneous candidiasis (HP:0002728)2.91999377
17Recurrent cutaneous fungal infections (HP:0011370)2.91999377
18Inflammation of the large intestine (HP:0002037)2.86772612
19Short nail (HP:0001799)2.85374695
20Increased IgE level (HP:0003212)2.81918615
21Long toe (HP:0010511)2.70290887
22Pigmentary retinal degeneration (HP:0001146)2.69276239
23Obstructive sleep apnea (HP:0002870)2.66957684
24Spondylolisthesis (HP:0003302)2.66601882
25Recurrent skin infections (HP:0001581)2.65438106
26Hematochezia (HP:0002573)2.63297752
27Gastrointestinal infarctions (HP:0005244)2.61042456
28Agammaglobulinemia (HP:0004432)2.58749847
29Recurrent bacterial skin infections (HP:0005406)2.55290087
30Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.53928004
31Abnormality of the nasal septum (HP:0000419)2.50554686
32Panhypogammaglobulinemia (HP:0003139)2.48309088
33Aplasia/Hypoplasia of the macula (HP:0008059)2.47481738
34Chronic obstructive pulmonary disease (HP:0006510)2.46483528
35Obstructive lung disease (HP:0006536)2.46483528
36Eczematoid dermatitis (HP:0000976)2.43048806
37Viral hepatitis (HP:0006562)2.34647280
38Bowing of the arm (HP:0006488)2.34064987
39Bowed forearm bones (HP:0003956)2.34064987
40Arterial thrombosis (HP:0004420)2.32041858
41Thoracic kyphosis (HP:0002942)2.31665119
42Broad face (HP:0000283)2.31094370
43Difficulty running (HP:0009046)2.29296564
44Recurrent abscess formation (HP:0002722)2.29159288
45Hypoglycemic seizures (HP:0002173)2.28969873
46Epistaxis (HP:0000421)2.28403732
47Gingival bleeding (HP:0000225)2.26496863
48Congenital stationary night blindness (HP:0007642)2.25332643
49Chest pain (HP:0100749)2.22883962
50Increased cerebral lipofuscin (HP:0011813)2.21231843
51Aortic aneurysm (HP:0004942)2.20856698
52Aplasia/Hypoplasia affecting the retina (HP:0008061)2.19611664
53Ocular albinism (HP:0001107)2.18950661
54Genetic anticipation (HP:0003743)2.18902728
55Osteomyelitis (HP:0002754)2.15238794
56Hypochromic anemia (HP:0001931)2.14857591
57Orchitis (HP:0100796)2.14717988
58Albinism (HP:0001022)2.14152309
59Vasculitis (HP:0002633)2.13556665
60Frequent falls (HP:0002359)2.12835487
61Deep venous thrombosis (HP:0002625)2.11549255
62Encephalitis (HP:0002383)2.11295283
63Hemoptysis (HP:0002105)2.10754293
64Micronodular cirrhosis (HP:0001413)2.09225385
65Exercise-induced myalgia (HP:0003738)2.07738529
66Elevated erythrocyte sedimentation rate (HP:0003565)2.06126460
67Increased neuronal autofluorescent lipopigment (HP:0002074)2.04685287
68Abnormality of the lumbar spine (HP:0100712)2.03959050
69Myositis (HP:0100614)2.02109566
70Portal hypertension (HP:0001409)2.01763971
71Recurrent gram-negative bacterial infections (HP:0005420)2.01330725
72Keratoconjunctivitis sicca (HP:0001097)2.01318504
73Rectal prolapse (HP:0002035)2.01001388
74Flat acetabular roof (HP:0003180)2.00337133
75Lip pit (HP:0100267)1.99895444
76Urinary glycosaminoglycan excretion (HP:0003541)1.99326292
77Mucopolysacchariduria (HP:0008155)1.99326292
78Pulmonary embolism (HP:0002204)1.99238533
79Dislocated radial head (HP:0003083)1.98981183
80Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98875460
81Abnormality of polysaccharide metabolism (HP:0011012)1.98875460
82Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98875460
83Generalized hypopigmentation (HP:0007513)1.98389879
84Urticaria (HP:0001025)1.98215992
85Subacute progressive viral hepatitis (HP:0006572)1.97574722
86Aneurysm (HP:0002617)1.96709473
87Coarse hair (HP:0002208)1.96595112
88Neonatal hypoglycemia (HP:0001998)1.95934209
89Absent frontal sinuses (HP:0002688)1.94158128
90Retrobulbar optic neuritis (HP:0100654)1.93850133
91Optic neuritis (HP:0100653)1.93850133
92T lymphocytopenia (HP:0005403)1.92809686
93Centrally nucleated skeletal muscle fibers (HP:0003687)1.91783336
94Aplasia/Hypoplasia of the fovea (HP:0008060)1.90967552
95Hypoplasia of the fovea (HP:0007750)1.90967552
96Mitral valve prolapse (HP:0001634)1.90504927
97Interstitial pulmonary disease (HP:0006530)1.90320899
98Recurrent fungal infections (HP:0002841)1.89741889
99Abnormality of the thoracic spine (HP:0100711)1.89474657
100Stomatitis (HP:0010280)1.89318226
101Slow saccadic eye movements (HP:0000514)1.88585538
102Polygenic inheritance (HP:0010982)1.88072773
103Truncal obesity (HP:0001956)1.87086649
104Enlarged penis (HP:0000040)1.85425577
105Dyschromatopsia (HP:0007641)1.83925566
106Recurrent bronchitis (HP:0002837)1.83206434
107Striae distensae (HP:0001065)1.83192177
108Abnormality of the hepatic vasculature (HP:0006707)1.82998459
109Abnormality of T cell number (HP:0011839)1.81445388
110Segmental peripheral demyelination/remyelination (HP:0003481)1.81025269
111Bilateral sensorineural hearing impairment (HP:0008619)1.80500242
112Cellulitis (HP:0100658)1.80460822
113Periodontitis (HP:0000704)1.79017556
114Arterial tortuosity (HP:0005116)1.78890458
115Abnormality of the radial head (HP:0003995)1.78759423
116Hemorrhage of the eye (HP:0011885)1.77125670
117Progressive visual loss (HP:0000529)1.76943833
118Myocardial infarction (HP:0001658)1.76840922
119Abnormal delayed hypersensitivity skin test (HP:0002963)1.76218352
120Pustule (HP:0200039)1.74531014
121Fatigue (HP:0012378)1.73343601
122Pulmonary infiltrates (HP:0002113)1.73112127
123Loss of speech (HP:0002371)1.73104686
124Prostate neoplasm (HP:0100787)1.72989411
125Gingivitis (HP:0000230)1.72229121
126Esophageal varix (HP:0002040)1.71850621
127Papilloma (HP:0012740)1.71605830
128Verrucae (HP:0200043)1.71605830
129Hepatitis (HP:0012115)1.71400929
130Beaking of vertebral bodies (HP:0004568)1.71085536
131Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70599488
132Granulocytopenia (HP:0001913)1.70277376
133Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.70117937
134Abnormality of T cells (HP:0002843)1.70083602
135Abnormality of T cell physiology (HP:0011840)1.69558609
136Hypochromic microcytic anemia (HP:0004840)1.67353411
137Ovoid vertebral bodies (HP:0003300)1.67135562
138Abnormality of the endocardium (HP:0004306)1.66870995
139Spinal muscular atrophy (HP:0007269)1.66272848
140Asymmetric septal hypertrophy (HP:0001670)1.65161809
141Increased CSF protein (HP:0002922)1.65085687
142Keratoconjunctivitis (HP:0001096)1.64947932
143Amyloidosis (HP:0011034)1.64386562
144Abnormality of the periventricular white matter (HP:0002518)1.63989538
145Blue irides (HP:0000635)1.63668611
146Autoimmune thrombocytopenia (HP:0001973)1.63261523
147Distal lower limb amyotrophy (HP:0008944)1.62996540
148Dysostosis multiplex (HP:0000943)1.62759672
149Thickened calvaria (HP:0002684)1.62403556
150Broad distal phalanx of finger (HP:0009836)1.62339828
151Recurrent viral infections (HP:0004429)1.60128648
152Vascular tortuosity (HP:0004948)1.59907866
153Prolonged bleeding time (HP:0003010)1.59800562
154Bruising susceptibility (HP:0000978)1.59354041
155Cervical subluxation (HP:0003308)1.58706405
156Iris hypopigmentation (HP:0007730)1.58574980
157Narrow palate (HP:0000189)1.58244222
158Protrusio acetabuli (HP:0003179)1.56909199
159Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.56836858
160Smooth philtrum (HP:0000319)1.56822037
161Lymphopenia (HP:0001888)1.56671298
162Systemic lupus erythematosus (HP:0002725)1.56636418
163Petechiae (HP:0000967)1.55922176
164Insulin-resistant diabetes mellitus (HP:0000831)1.55663968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK13.46852153
2INSRR3.28898150
3PRPF4B2.99442877
4CDK122.97813877
5LATS12.49605384
6SIK32.30915441
7SIK22.15270056
8FRK2.04175867
9RIPK11.99226755
10SMG11.89366642
11BLK1.88037326
12MARK31.68873862
13MAP2K21.67314926
14MAP3K141.62475258
15PKN21.60480179
16TGFBR21.56880597
17TAOK31.56733341
18MST1R1.56050598
19IRAK21.52463005
20PTK61.52042355
21TNK21.48799093
22SGK31.46800260
23ERN11.40793873
24PIK3CG1.39592230
25MAP4K11.36167540
26NUAK11.35144496
27FES1.33260857
28SGK21.29992913
29CHUK1.29617082
30NLK1.28792156
31BMX1.28298171
32FGFR41.26930352
33MAP3K101.26175887
34EEF2K1.25938409
35CAMK1D1.25931743
36TTN1.24380756
37GRK61.23559865
38MAP3K71.23506355
39CAMK1G1.22126456
40YES11.20268229
41TAOK11.19856910
42JAK31.18636165
43BTK1.11154859
44TXK1.11120857
45MARK21.10479097
46SCYL21.06989053
47WNK11.06122380
48TYK21.05693572
49SYK1.02410729
50EPHB11.01569114
51STK101.01515858
52ITK1.01430735
53TRIB31.00918509
54MAPK120.99868433
55TEC0.99108220
56CDC42BPA0.98795010
57IRAK30.97459967
58JAK10.97000441
59CDK90.89535247
60MAP3K130.89508015
61TYRO30.87160171
62PDGFRB0.86812585
63MELK0.86664914
64MAP3K10.86306290
65MTOR0.85701053
66PDPK10.85554857
67PRKD20.85344193
68EPHA20.85284830
69ZAP700.84462750
70PDK10.83366576
71HIPK20.81768091
72MAPK150.81689032
73MAPK70.81360256
74EPHA30.81136708
75FGFR30.80547909
76RPS6KA20.79895007
77PTK20.79817453
78IRAK10.78423327
79IRAK40.77690738
80TRPM70.77598815
81TBK10.76924068
82MAP2K30.75870071
83BRD40.75364789
84CSF1R0.75331951
85RIPK40.75302166
86LCK0.74222216
87MAP3K90.73294421
88PDGFRA0.72798029
89ZAK0.72535168
90MAP3K60.72528012
91MAP3K110.71307596
92IKBKB0.71193190
93KSR20.70400472
94ICK0.69349067
95LYN0.68939209
96JAK20.68713558
97MAP3K20.68182266
98RPS6KA40.68135544
99PRKCH0.68043979
100MAP3K30.67886377
101CDK40.66357818
102STK110.66209359
103CSK0.65771790
104MET0.65647836
105STK30.65027227
106MAPK110.62724818
107SGK2230.62509071
108SGK4940.62509071
109IKBKE0.62160422
110HCK0.61564403
111CDK60.60574891
112RPS6KA60.59581724
113RPS6KA50.59302802
114RPS6KB20.59218024
115MAP3K40.58414703
116MAP3K80.57883285
117TAOK20.56838749
118RPS6KA10.56664245
119STK380.55442276
120FLT30.54983317
121DYRK1B0.54103190
122LRRK20.53750180
123RPS6KL10.53110476
124RPS6KC10.53110476
125FGR0.51868547
126MAP2K60.51198982
127RET0.50846627
128RPS6KB10.50303313
129DAPK20.49944393
130SGK10.49679346
131MATK0.49230348
132NEK90.48598706
133AKT30.48569653
134INSR0.48531693
135KIT0.47447593

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.06113293
2Osteoclast differentiation_Homo sapiens_hsa043801.86214450
3Type II diabetes mellitus_Homo sapiens_hsa049301.81193872
4NF-kappa B signaling pathway_Homo sapiens_hsa040641.75321387
5mTOR signaling pathway_Homo sapiens_hsa041501.66778535
6Leishmaniasis_Homo sapiens_hsa051401.58287176
7TNF signaling pathway_Homo sapiens_hsa046681.57902279
8Other glycan degradation_Homo sapiens_hsa005111.57062659
9B cell receptor signaling pathway_Homo sapiens_hsa046621.54004631
10Acute myeloid leukemia_Homo sapiens_hsa052211.49547522
11Notch signaling pathway_Homo sapiens_hsa043301.48935865
12Insulin resistance_Homo sapiens_hsa049311.46555569
13Chronic myeloid leukemia_Homo sapiens_hsa052201.46075262
14VEGF signaling pathway_Homo sapiens_hsa043701.44366437
15Adherens junction_Homo sapiens_hsa045201.41409240
16Allograft rejection_Homo sapiens_hsa053301.41084772
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34103774
18Autoimmune thyroid disease_Homo sapiens_hsa053201.34053698
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31791793
20FoxO signaling pathway_Homo sapiens_hsa040681.27499069
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27257286
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26916547
23Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25690213
24Phototransduction_Homo sapiens_hsa047441.22667960
25Toxoplasmosis_Homo sapiens_hsa051451.22662510
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.19222635
27Longevity regulating pathway - mammal_Homo sapiens_hsa042111.16093413
28Measles_Homo sapiens_hsa051621.15829476
29Choline metabolism in cancer_Homo sapiens_hsa052311.15652305
30Adipocytokine signaling pathway_Homo sapiens_hsa049201.13086719
31Pancreatic cancer_Homo sapiens_hsa052121.12468079
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.11092791
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10525872
34Herpes simplex infection_Homo sapiens_hsa051681.08720659
35Chemokine signaling pathway_Homo sapiens_hsa040621.07970738
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.07056379
37Platelet activation_Homo sapiens_hsa046111.06796117
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06080321
39Prolactin signaling pathway_Homo sapiens_hsa049171.05321339
40Malaria_Homo sapiens_hsa051441.04441310
41Amoebiasis_Homo sapiens_hsa051461.04424855
42Focal adhesion_Homo sapiens_hsa045101.02776314
43Inositol phosphate metabolism_Homo sapiens_hsa005621.02315810
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01856077
45Apoptosis_Homo sapiens_hsa042101.01381010
46Proteoglycans in cancer_Homo sapiens_hsa052051.00019168
47Dorso-ventral axis formation_Homo sapiens_hsa043201.00011105
48Lysine degradation_Homo sapiens_hsa003100.99951085
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99021626
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98540764
51Thyroid cancer_Homo sapiens_hsa052160.97934710
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.96976850
53Hepatitis B_Homo sapiens_hsa051610.96126266
54Asthma_Homo sapiens_hsa053100.95350182
55Lysosome_Homo sapiens_hsa041420.94683467
56Tuberculosis_Homo sapiens_hsa051520.94609412
57T cell receptor signaling pathway_Homo sapiens_hsa046600.93381200
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93360097
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.93243586
60Circadian rhythm_Homo sapiens_hsa047100.92879476
61Small cell lung cancer_Homo sapiens_hsa052220.92622813
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90704110
63Antigen processing and presentation_Homo sapiens_hsa046120.89041605
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88472093
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87602253
66Prostate cancer_Homo sapiens_hsa052150.87547008
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.86475387
68GnRH signaling pathway_Homo sapiens_hsa049120.85435483
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84569619
70Glioma_Homo sapiens_hsa052140.84255421
71Caffeine metabolism_Homo sapiens_hsa002320.83429340
72Dilated cardiomyopathy_Homo sapiens_hsa054140.82919551
73Bladder cancer_Homo sapiens_hsa052190.82629114
74ErbB signaling pathway_Homo sapiens_hsa040120.81230270
75AMPK signaling pathway_Homo sapiens_hsa041520.80849023
76Endometrial cancer_Homo sapiens_hsa052130.77985805
77Viral myocarditis_Homo sapiens_hsa054160.77881942
78Influenza A_Homo sapiens_hsa051640.77718877
79Legionellosis_Homo sapiens_hsa051340.77395391
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76662998
81MAPK signaling pathway_Homo sapiens_hsa040100.76197441
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75489718
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74173189
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74057163
85Renal cell carcinoma_Homo sapiens_hsa052110.73844476
86MicroRNAs in cancer_Homo sapiens_hsa052060.73739410
87Salmonella infection_Homo sapiens_hsa051320.72973025
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.72647241
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71351658
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.70361189
91Insulin secretion_Homo sapiens_hsa049110.69525992
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69456768
93Endocytosis_Homo sapiens_hsa041440.69453019
94Hepatitis C_Homo sapiens_hsa051600.69140800
95Non-small cell lung cancer_Homo sapiens_hsa052230.68540158
96Pertussis_Homo sapiens_hsa051330.68455086
97Type I diabetes mellitus_Homo sapiens_hsa049400.68373468
98Estrogen signaling pathway_Homo sapiens_hsa049150.67645312
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67539057
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66951136
101Colorectal cancer_Homo sapiens_hsa052100.66782079
102Insulin signaling pathway_Homo sapiens_hsa049100.65645966
103HTLV-I infection_Homo sapiens_hsa051660.64971537
104Rap1 signaling pathway_Homo sapiens_hsa040150.64357963
105Glucagon signaling pathway_Homo sapiens_hsa049220.64220056
106Cholinergic synapse_Homo sapiens_hsa047250.61775344
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61555446
108ABC transporters_Homo sapiens_hsa020100.61121053
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.60592038
110Graft-versus-host disease_Homo sapiens_hsa053320.60391269
111Oxytocin signaling pathway_Homo sapiens_hsa049210.59208695
112Primary immunodeficiency_Homo sapiens_hsa053400.58760518
113Pathways in cancer_Homo sapiens_hsa052000.58468415
114HIF-1 signaling pathway_Homo sapiens_hsa040660.57796059
115Hematopoietic cell lineage_Homo sapiens_hsa046400.57623380
116Viral carcinogenesis_Homo sapiens_hsa052030.57440750
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57241080
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57158848
119Olfactory transduction_Homo sapiens_hsa047400.54997004
120Complement and coagulation cascades_Homo sapiens_hsa046100.53358776
121Long-term potentiation_Homo sapiens_hsa047200.52682770
122Epstein-Barr virus infection_Homo sapiens_hsa051690.47850445
123African trypanosomiasis_Homo sapiens_hsa051430.46799306

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