ZYG11B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)6.11231783
2muscle filament sliding (GO:0030049)6.11231783
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.95866824
4sarcoplasmic reticulum calcium ion transport (GO:0070296)5.94690855
5synaptic vesicle maturation (GO:0016188)5.37904344
6locomotory exploration behavior (GO:0035641)5.25567142
7actin-mediated cell contraction (GO:0070252)5.22362917
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.16455000
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.14356325
10vocalization behavior (GO:0071625)5.12126331
11layer formation in cerebral cortex (GO:0021819)5.09290030
12regulation of relaxation of muscle (GO:1901077)5.02631122
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.99235321
14regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.89896798
15glutamate secretion (GO:0014047)4.81493959
16synaptic vesicle exocytosis (GO:0016079)4.78873991
17myofibril assembly (GO:0030239)4.77637015
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.66126309
19regulation of skeletal muscle contraction (GO:0014819)4.66064363
20regulation of cell communication by electrical coupling (GO:0010649)4.45780575
21regulation of synaptic vesicle exocytosis (GO:2000300)4.42857898
22protein localization to synapse (GO:0035418)4.41477967
23regulation of glutamate receptor signaling pathway (GO:1900449)4.40733430
24exploration behavior (GO:0035640)4.38515844
25neuron cell-cell adhesion (GO:0007158)4.36580350
26ionotropic glutamate receptor signaling pathway (GO:0035235)4.28875244
27dendritic spine morphogenesis (GO:0060997)4.25517802
28skeletal muscle contraction (GO:0003009)4.23630064
29synaptic vesicle docking involved in exocytosis (GO:0016081)4.20848529
30cardiac myofibril assembly (GO:0055003)4.18282116
31striated muscle contraction (GO:0006941)4.17727152
32presynaptic membrane organization (GO:0097090)4.14543588
33regulation of long-term neuronal synaptic plasticity (GO:0048169)4.09302116
34proline transport (GO:0015824)4.09114769
35sarcomere organization (GO:0045214)4.08905095
36regulation of synapse structural plasticity (GO:0051823)4.07865578
37neurotransmitter secretion (GO:0007269)4.00967573
38presynaptic membrane assembly (GO:0097105)3.95731991
39actin filament-based movement (GO:0030048)3.92762954
40response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.91585611
41regulation of synaptic vesicle transport (GO:1902803)3.91214064
42regulation of neuronal synaptic plasticity (GO:0048168)3.89944549
43pyrimidine nucleobase catabolic process (GO:0006208)3.88835618
44dendrite morphogenesis (GO:0048813)3.82780657
45neuron recognition (GO:0008038)3.82182862
46response to inactivity (GO:0014854)3.80902615
47synaptic transmission, glutamatergic (GO:0035249)3.78817727
48regulation of actin filament-based movement (GO:1903115)3.78180708
49glutamate receptor signaling pathway (GO:0007215)3.77939756
50regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.76819391
51neurotransmitter-gated ion channel clustering (GO:0072578)3.73034816
52regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.71694714
53cardiac muscle contraction (GO:0060048)3.68808002
54regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.68210300
55cardiac muscle hypertrophy (GO:0003300)3.66529495
56gamma-aminobutyric acid transport (GO:0015812)3.63108158
57neuron-neuron synaptic transmission (GO:0007270)3.60707256
58regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.57480555
59regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.57068251
60positive regulation of synapse maturation (GO:0090129)3.56695153
61axonal fasciculation (GO:0007413)3.55601255
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.53360599
63activation of protein kinase A activity (GO:0034199)3.52485561
64positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.50692067
65striated muscle hypertrophy (GO:0014897)3.49141188
66nucleobase catabolic process (GO:0046113)3.47186089
67regulation of excitatory postsynaptic membrane potential (GO:0060079)3.42122712
68plasma membrane repair (GO:0001778)3.41026263
69central nervous system projection neuron axonogenesis (GO:0021952)3.40864326
70regulation of dendritic spine morphogenesis (GO:0061001)3.36792834
71actomyosin structure organization (GO:0031032)3.36342578
72long-term memory (GO:0007616)3.35304948
73cellular potassium ion homeostasis (GO:0030007)3.32275205
74regulation of postsynaptic membrane potential (GO:0060078)3.31877485
75cell migration in hindbrain (GO:0021535)3.31547627
76negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.29760506
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.25928901
78muscle contraction (GO:0006936)3.22988382
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.21074513
80neuronal action potential propagation (GO:0019227)3.20566644
81innervation (GO:0060384)3.19390768
82neurotransmitter transport (GO:0006836)3.17790673
83response to muscle activity (GO:0014850)3.17342687
84synaptic vesicle endocytosis (GO:0048488)3.15947226
85positive regulation of membrane potential (GO:0045838)3.15424981
86sodium ion export (GO:0071436)3.12831529
87postsynaptic membrane organization (GO:0001941)3.11438974
88myotube cell development (GO:0014904)3.11400150
89vesicle transport along microtubule (GO:0047496)3.10934192
90neuromuscular process controlling balance (GO:0050885)3.09331411
91neuromuscular synaptic transmission (GO:0007274)3.09057653
92skeletal muscle fiber development (GO:0048741)3.08864942
93regulation of synaptic plasticity (GO:0048167)3.07458974
94negative regulation of cytosolic calcium ion concentration (GO:0051481)3.06874146
95cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.06603059
96cerebellar Purkinje cell differentiation (GO:0021702)3.06526082
97cell communication by electrical coupling (GO:0010644)3.05924705
98organelle transport along microtubule (GO:0072384)3.05432912
99regulation of sarcomere organization (GO:0060297)3.05327400
100establishment of nucleus localization (GO:0040023)3.03635195
101muscle hypertrophy (GO:0014896)3.01286426
102negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01215251
103axon extension (GO:0048675)3.00115436
104regulation of calcium ion transmembrane transporter activity (GO:1901019)2.99655510
105regulation of calcium ion transmembrane transport (GO:1903169)2.99655510
106auditory behavior (GO:0031223)2.99272759
107muscle fiber development (GO:0048747)2.98998334
108synapse assembly (GO:0007416)2.96963688
109prepulse inhibition (GO:0060134)2.96360665
110creatine metabolic process (GO:0006600)2.96334841
111regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.95296092
112clathrin coat assembly (GO:0048268)2.94963388
113positive regulation of synaptic transmission, GABAergic (GO:0032230)2.94555949
114gamma-aminobutyric acid signaling pathway (GO:0007214)2.94456068
115transmission of nerve impulse (GO:0019226)2.94189897
116muscle system process (GO:0003012)2.93610779
117regulation of membrane repolarization (GO:0060306)2.93040056
118regulation of neurotransmitter levels (GO:0001505)2.92952390
119social behavior (GO:0035176)2.92786727
120intraspecies interaction between organisms (GO:0051703)2.92786727
121myotube differentiation (GO:0014902)2.92761009
122regulation of neurotransmitter secretion (GO:0046928)2.92049799
123behavioral fear response (GO:0001662)2.91861289
124behavioral defense response (GO:0002209)2.91861289
125cardiac muscle cell development (GO:0055013)2.90647442
126regulation of synaptic transmission, glutamatergic (GO:0051966)2.90496331
127regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.89826216
128regulation of dendritic spine development (GO:0060998)2.89536156
129G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.88959009
130regulation of ARF protein signal transduction (GO:0032012)2.88644709
131negative regulation of potassium ion transmembrane transport (GO:1901380)2.88638648
132positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.88574247
133response to auditory stimulus (GO:0010996)2.88413179
134long-term synaptic potentiation (GO:0060291)2.88041456
135regulation of striated muscle contraction (GO:0006942)2.87066565
136cardiac muscle hypertrophy in response to stress (GO:0014898)2.85964638
137muscle hypertrophy in response to stress (GO:0003299)2.85964638
138cardiac muscle adaptation (GO:0014887)2.85964638
139positive regulation of dendritic spine morphogenesis (GO:0061003)2.84373104
140synapse organization (GO:0050808)2.82113128
141dendritic spine organization (GO:0097061)2.81494973
142cerebellar granule cell differentiation (GO:0021707)2.79759995
143establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.78842769
144mitochondrion transport along microtubule (GO:0047497)2.78842769
145adult heart development (GO:0007512)2.78749115
146carnitine shuttle (GO:0006853)2.78006148
147regulation of skeletal muscle cell differentiation (GO:2001014)2.77845652
148regulation of vesicle fusion (GO:0031338)2.76550982
149membrane depolarization (GO:0051899)2.75741069
150striated muscle adaptation (GO:0014888)2.75608333
151positive regulation of cation channel activity (GO:2001259)2.75063644
152positive regulation of dendritic spine development (GO:0060999)2.74906968
153relaxation of cardiac muscle (GO:0055119)2.74360513
154regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.74338669
155glycogen catabolic process (GO:0005980)2.73939779
156negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.73245080
157learning (GO:0007612)2.72457063
158membrane depolarization during action potential (GO:0086010)2.69804162
159fear response (GO:0042596)2.69484605
160cardiac cell development (GO:0055006)2.68723764
161relaxation of muscle (GO:0090075)2.67677899
162positive regulation of cardiac muscle cell differentiation (GO:2000727)2.65866605
163regulation of cardiac muscle cell contraction (GO:0086004)2.64626897
164regulation of cAMP-dependent protein kinase activity (GO:2000479)2.63514686
165cell communication involved in cardiac conduction (GO:0086065)2.62851922
166skeletal muscle adaptation (GO:0043501)2.62376737
167regulation of potassium ion transmembrane transporter activity (GO:1901016)2.60339381
168skeletal muscle tissue development (GO:0007519)2.60273699
169nucleus localization (GO:0051647)2.59910786
170fatty acid transmembrane transport (GO:1902001)2.54470654
171glucan catabolic process (GO:0009251)2.52705145
172striated muscle cell development (GO:0055002)2.52538429
173muscle cell cellular homeostasis (GO:0046716)2.50630180
174cardiac muscle cell action potential (GO:0086001)2.45680434
175response to epinephrine (GO:0071871)2.44524807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.38015721
2GBX2_23144817_ChIP-Seq_PC3_Human3.50484950
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.77883681
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76831379
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74578215
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47079682
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47079682
8REST_21632747_ChIP-Seq_MESCs_Mouse2.35123779
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31973661
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31668593
11DROSHA_22980978_ChIP-Seq_HELA_Human2.30642787
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29774821
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28472065
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26162978
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26107376
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.25792194
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22067334
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20381914
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.17707785
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07695618
21AR_21572438_ChIP-Seq_LNCaP_Human2.06809431
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.03280353
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.00550613
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.00367418
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.99160366
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95627784
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95105479
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.86397279
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.81524927
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78837551
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75243574
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74059459
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73393740
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.68783316
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67867256
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66618672
37TAF15_26573619_Chip-Seq_HEK293_Human1.66576714
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60777813
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59475904
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.52051226
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.51610872
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.50907306
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.50907306
44VDR_22108803_ChIP-Seq_LS180_Human1.50592704
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47095565
46ZNF274_21170338_ChIP-Seq_K562_Hela1.46192959
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46094891
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.43991275
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41692821
50P300_19829295_ChIP-Seq_ESCs_Human1.40894183
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39800105
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39630756
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39020844
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38030893
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35278250
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35201881
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34882478
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.32521828
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.32218592
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31674150
61STAT3_23295773_ChIP-Seq_U87_Human1.31066189
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31045249
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30511346
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30282728
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30203496
66ER_23166858_ChIP-Seq_MCF-7_Human1.30000862
67AR_19668381_ChIP-Seq_PC3_Human1.29703154
68IGF1R_20145208_ChIP-Seq_DFB_Human1.29222064
69AR_25329375_ChIP-Seq_VCAP_Human1.29027774
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28070403
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27996361
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.27673569
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.27020651
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26126350
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.25828650
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.24473481
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24364602
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.22929861
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22655148
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22285152
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21829192
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20579819
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20095903
84AHR_22903824_ChIP-Seq_MCF-7_Human1.19342391
85LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19234163
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18754268
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.18348238
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17994022
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17866721
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.17597117
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16932732
92P53_22387025_ChIP-Seq_ESCs_Mouse1.16139066
93E2F1_18555785_Chip-Seq_ESCs_Mouse1.15519436
94CBX2_27304074_Chip-Seq_ESCs_Mouse1.14244339
95SOX9_26525672_Chip-Seq_HEART_Mouse1.13498806
96CBP_20019798_ChIP-Seq_JUKART_Human1.13116893
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13116893
98TCF4_23295773_ChIP-Seq_U87_Human1.12971799
99RING1B_27294783_Chip-Seq_NPCs_Mouse1.12668308
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11703291
101KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10863831
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10603943
103TP53_16413492_ChIP-PET_HCT116_Human1.10563542
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10229991
105EWS_26573619_Chip-Seq_HEK293_Human1.09712279
106KDM2B_26808549_Chip-Seq_K562_Human1.09614587
107TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07859765
108KDM2B_26808549_Chip-Seq_REH_Human1.07576495
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07532260
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07393906
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06511717
112RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05402225
113* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04591095
114BCAT_22108803_ChIP-Seq_LS180_Human1.03942931
115SMAD4_21741376_ChIP-Seq_HESCs_Human1.02768393
116P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02591589
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02460164
118ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02339222
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01839591
120DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01770446
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00910409
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00910409
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99000255
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98376529
125FUS_26573619_Chip-Seq_HEK293_Human0.98219913
126RXR_22108803_ChIP-Seq_LS180_Human0.97546878
127RUNX2_22187159_ChIP-Seq_PCA_Human0.97539747
128PRDM14_20953172_ChIP-Seq_ESCs_Human0.97405646
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96232847
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95924214
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.93669583
132* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93497822
133RNF2_27304074_Chip-Seq_NSC_Mouse0.92987789
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.91953493
135TP53_18474530_ChIP-ChIP_U2OS_Human0.90768171
136CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90598636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.40569894
2MP0003646_muscle_fatigue4.09279723
3MP0003635_abnormal_synaptic_transmissio4.08996202
4MP0004270_analgesia3.96385737
5MP0003880_abnormal_central_pattern3.84057684
6MP0000749_muscle_degeneration3.59262538
7MP0002063_abnormal_learning/memory/cond3.33692155
8MP0009745_abnormal_behavioral_response3.15724669
9MP0004036_abnormal_muscle_relaxation3.07183435
10MP0002064_seizures2.83766348
11MP0005423_abnormal_somatic_nervous2.72156477
12MP0009046_muscle_twitch2.68274362
13MP0004084_abnormal_cardiac_muscle2.67767068
14MP0001968_abnormal_touch/_nociception2.66717778
15MP0002572_abnormal_emotion/affect_behav2.63335497
16MP0002734_abnormal_mechanical_nocicepti2.55432891
17MP0009780_abnormal_chondrocyte_physiolo2.40468322
18MP0001486_abnormal_startle_reflex2.36648825
19MP0002106_abnormal_muscle_physiology2.32893954
20MP0000778_abnormal_nervous_system2.26475405
21MP0002735_abnormal_chemical_nociception2.23789803
22MP0004087_abnormal_muscle_fiber2.17039268
23MP0001440_abnormal_grooming_behavior2.14934152
24MP0002272_abnormal_nervous_system2.13669749
25MP0000569_abnormal_digit_pigmentation2.08405599
26MP0002733_abnormal_thermal_nociception2.03747929
27MP0000759_abnormal_skeletal_muscle2.03251029
28MP0005369_muscle_phenotype2.02445404
29MP0002822_catalepsy1.98030016
30MP0002269_muscular_atrophy1.92387416
31MP0002184_abnormal_innervation1.91375736
32MP0001501_abnormal_sleep_pattern1.88325673
33MP0004811_abnormal_neuron_physiology1.88005520
34MP0005386_behavior/neurological_phenoty1.86713601
35MP0004924_abnormal_behavior1.86713601
36MP0002067_abnormal_sensory_capabilities1.85707885
37MP0003329_amyloid_beta_deposits1.83501315
38MP0002736_abnormal_nociception_after1.82231077
39MP0002909_abnormal_adrenal_gland1.81933744
40MP0002332_abnormal_exercise_endurance1.81731589
41MP0004858_abnormal_nervous_system1.79601719
42MP0001970_abnormal_pain_threshold1.78777703
43MP0008569_lethality_at_weaning1.77380040
44MP0002557_abnormal_social/conspecific_i1.76722202
45MP0000955_abnormal_spinal_cord1.65697684
46MP0006276_abnormal_autonomic_nervous1.64727843
47MP0002972_abnormal_cardiac_muscle1.60620542
48MP0004130_abnormal_muscle_cell1.51310527
49MP0004885_abnormal_endolymph1.49497171
50MP0005330_cardiomyopathy1.48272168
51MP0002108_abnormal_muscle_morphology1.44943870
52MP0000750_abnormal_muscle_regeneration1.44843674
53MP0002882_abnormal_neuron_morphology1.42538001
54MP0003633_abnormal_nervous_system1.38132443
55MP0005187_abnormal_penis_morphology1.38000403
56MP0002066_abnormal_motor_capabilities/c1.36241737
57MP0002837_dystrophic_cardiac_calcinosis1.29280227
58MP0002638_abnormal_pupillary_reflex1.24523963
59MP0000733_abnormal_muscle_development1.24066637
60MP0002152_abnormal_brain_morphology1.22149288
61MP0001188_hyperpigmentation1.22052482
62MP0000751_myopathy1.21132037
63MP0001984_abnormal_olfaction1.21121345
64MP0010234_abnormal_vibrissa_follicle1.21020460
65MP0005646_abnormal_pituitary_gland1.20340634
66MP0003787_abnormal_imprinting1.20206515
67MP0003879_abnormal_hair_cell1.15986617
68MP0004145_abnormal_muscle_electrophysio1.15057219
69MP0003631_nervous_system_phenotype1.13581550
70MP0006138_congestive_heart_failure1.13160213
71MP0005645_abnormal_hypothalamus_physiol1.11256744
72MP0002127_abnormal_cardiovascular_syste1.08277385
73MP0001502_abnormal_circadian_rhythm1.06722314
74MP0010630_abnormal_cardiac_muscle1.05001875
75MP0001544_abnormal_cardiovascular_syste1.02809397
76MP0005385_cardiovascular_system_phenoty1.02809397
77MP0003122_maternal_imprinting1.02753111
78MP0008775_abnormal_heart_ventricle1.02289180
79MP0005248_abnormal_Harderian_gland1.00860466
80MP0008961_abnormal_basal_metabolism1.00043724
81MP0002971_abnormal_brown_adipose0.96833950
82MP0005535_abnormal_body_temperature0.96502391
83MP0001177_atelectasis0.96391183
84MP0003890_abnormal_embryonic-extraembry0.95850807
85MP0004085_abnormal_heartbeat0.93784882
86MP0002069_abnormal_eating/drinking_beha0.92718782
87MP0005551_abnormal_eye_electrophysiolog0.92484795
88MP0004215_abnormal_myocardial_fiber0.92384069
89MP0003221_abnormal_cardiomyocyte_apopto0.86995325
90MP0000013_abnormal_adipose_tissue0.86610774
91MP0002229_neurodegeneration0.86501082
92MP0003303_peritoneal_inflammation0.86179783
93MP0004484_altered_response_of0.85760929
94MP0003950_abnormal_plasma_membrane0.85134108
95MP0004142_abnormal_muscle_tone0.84847543
96MP0003137_abnormal_impulse_conducting0.83383476
97MP0004510_myositis0.82903081
98MP0001299_abnormal_eye_distance/0.82827276
99MP0000631_abnormal_neuroendocrine_gland0.82785487
100MP0000604_amyloidosis0.82627737
101MP0001905_abnormal_dopamine_level0.82453144
102MP0003634_abnormal_glial_cell0.81676427
103MP0005266_abnormal_metabolism0.81600321
104MP0002009_preneoplasia0.81120705
105MP0004233_abnormal_muscle_weight0.80904305
106MP0008874_decreased_physiological_sensi0.80457391
107MP0003632_abnormal_nervous_system0.79862903
108MP0002090_abnormal_vision0.79753592
109MP0003385_abnormal_body_wall0.76926226
110MP0004147_increased_porphyrin_level0.75782455
111MP0003861_abnormal_nervous_system0.75393303
112MP0004134_abnormal_chest_morphology0.74469419
113MP0003690_abnormal_glial_cell0.74255327
114MP0010386_abnormal_urinary_bladder0.72118206
115MP0009250_abnormal_appendicular_skeleto0.71276035
116MP0002752_abnormal_somatic_nervous0.71197949
117MP0005394_taste/olfaction_phenotype0.70262128
118MP0005499_abnormal_olfactory_system0.70262128
119MP0001529_abnormal_vocalization0.70252521
120MP0000747_muscle_weakness0.69736551
121MP0004742_abnormal_vestibular_system0.65915052
122MP0008872_abnormal_physiological_respon0.65317198
123MP0001661_extended_life_span0.64796604
124MP0005620_abnormal_muscle_contractility0.63571217
125MP0005623_abnormal_meninges_morphology0.63535885
126MP0005253_abnormal_eye_physiology0.63153669
127MP0004043_abnormal_pH_regulation0.62917643
128MP0002234_abnormal_pharynx_morphology0.59960412
129MP0000534_abnormal_ureter_morphology0.58905788
130MP0001943_abnormal_respiration0.57869138
131MP0010769_abnormal_survival0.57738837
132MP0005409_darkened_coat_color0.57714987
133MP0001963_abnormal_hearing_physiology0.57546076
134MP0010770_preweaning_lethality0.56447680
135MP0002082_postnatal_lethality0.56447680
136MP0005171_absent_coat_pigmentation0.55828005
137MP0010768_mortality/aging0.53134411

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)8.43195045
2Nemaline bodies (HP:0003798)8.31914187
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.12638872
4Type 1 muscle fiber predominance (HP:0003803)6.43100951
5Exercise-induced muscle cramps (HP:0003710)5.86884762
6Focal motor seizures (HP:0011153)5.86290178
7Exercise-induced myalgia (HP:0003738)5.62397906
8Muscle hypertrophy of the lower extremities (HP:0008968)5.33083279
9Calf muscle hypertrophy (HP:0008981)5.07036566
10Myokymia (HP:0002411)5.05935223
11Focal seizures (HP:0007359)4.85201083
12Distal arthrogryposis (HP:0005684)4.67280282
13Visual hallucinations (HP:0002367)4.45672173
14Abnormality of the calf musculature (HP:0001430)4.28701400
15Hyporeflexia of lower limbs (HP:0002600)4.09713867
16EMG: myopathic abnormalities (HP:0003458)3.98466643
17Rimmed vacuoles (HP:0003805)3.90121799
18Epileptic encephalopathy (HP:0200134)3.88527296
19Difficulty running (HP:0009046)3.78570205
20Progressive cerebellar ataxia (HP:0002073)3.73746663
21Muscle fiber splitting (HP:0003555)3.66126473
22Subaortic stenosis (HP:0001682)3.62127339
23Abnormality of the left ventricular outflow tract (HP:0011103)3.62127339
24Ankle clonus (HP:0011448)3.45262713
25Febrile seizures (HP:0002373)3.43854989
26Round ear (HP:0100830)3.42227866
27Sudden death (HP:0001699)3.40571632
28Bundle branch block (HP:0011710)3.40175574
29Papilledema (HP:0001085)3.38663446
30Absence seizures (HP:0002121)3.38230483
31Broad-based gait (HP:0002136)3.33485941
32Supranuclear gaze palsy (HP:0000605)3.32820673
33Frequent falls (HP:0002359)3.32732242
34Drooling (HP:0002307)3.31792850
35Excessive salivation (HP:0003781)3.31792850
36Atonic seizures (HP:0010819)3.31690281
37Action tremor (HP:0002345)3.30841513
38Myoglobinuria (HP:0002913)3.27655359
39Urinary bladder sphincter dysfunction (HP:0002839)3.25240286
40Neck muscle weakness (HP:0000467)3.24279005
41Impaired vibration sensation in the lower limbs (HP:0002166)3.22367310
42Hyperventilation (HP:0002883)3.19723045
43Myopathic facies (HP:0002058)3.19277543
44Mutism (HP:0002300)3.18294333
45Generalized tonic-clonic seizures (HP:0002069)3.16372565
46Poor eye contact (HP:0000817)3.15486061
47Dialeptic seizures (HP:0011146)3.06921888
48Myotonia (HP:0002486)3.05709830
49Termporal pattern (HP:0011008)3.04994455
50Insidious onset (HP:0003587)3.04994455
51Impaired social interactions (HP:0000735)2.98457266
52Abnormal social behavior (HP:0012433)2.98457266
53Genetic anticipation (HP:0003743)2.96825685
54Truncal ataxia (HP:0002078)2.96361903
55Urinary urgency (HP:0000012)2.94111859
56Absent phalangeal crease (HP:0006109)2.93121475
57Rhabdomyolysis (HP:0003201)2.88837848
58Depression (HP:0000716)2.87406942
59Abnormality of the corticospinal tract (HP:0002492)2.78491734
60Ulnar deviation of the wrist (HP:0003049)2.74847224
61Calcaneovalgus deformity (HP:0001848)2.73499460
62Abnormality of skeletal muscle fiber size (HP:0012084)2.72915577
63Dysdiadochokinesis (HP:0002075)2.72676556
64Absent speech (HP:0001344)2.67360419
65Cerebral inclusion bodies (HP:0100314)2.65527890
66Abnormality of the lower motor neuron (HP:0002366)2.64351206
67EMG: neuropathic changes (HP:0003445)2.62929019
68Scanning speech (HP:0002168)2.62626187
69Abnormal finger flexion creases (HP:0006143)2.62186982
70Amyotrophic lateral sclerosis (HP:0007354)2.60883920
71Postural instability (HP:0002172)2.60692481
72Agitation (HP:0000713)2.60412694
73Spastic gait (HP:0002064)2.60068357
74Areflexia of lower limbs (HP:0002522)2.59684034
75Gaze-evoked nystagmus (HP:0000640)2.59293483
76Centrally nucleated skeletal muscle fibers (HP:0003687)2.53405087
77Hepatoblastoma (HP:0002884)2.50159930
78Increased variability in muscle fiber diameter (HP:0003557)2.48726458
79Deformed tarsal bones (HP:0008119)2.48168620
80Abnormal eating behavior (HP:0100738)2.47278587
81Dysmetria (HP:0001310)2.46054417
82Anxiety (HP:0000739)2.46021719
83Epileptiform EEG discharges (HP:0011182)2.42925672
84Amblyopia (HP:0000646)2.42474986
85Inappropriate behavior (HP:0000719)2.41454751
86Dysmetric saccades (HP:0000641)2.39839426
87EEG with generalized epileptiform discharges (HP:0011198)2.38216898
88Inability to walk (HP:0002540)2.37284183
89Limb dystonia (HP:0002451)2.36804261
90Neoplasm of the adrenal cortex (HP:0100641)2.36146848
91Neurofibrillary tangles (HP:0002185)2.35420950
92Intention tremor (HP:0002080)2.33803058
93Lower limb muscle weakness (HP:0007340)2.31008161
94Stereotypic behavior (HP:0000733)2.30627007
95Impaired smooth pursuit (HP:0007772)2.30301557
96Megalencephaly (HP:0001355)2.30117606
97Progressive inability to walk (HP:0002505)2.30022151
98Hypsarrhythmia (HP:0002521)2.29764605
99Torticollis (HP:0000473)2.28979914
100Bradykinesia (HP:0002067)2.25284424
101Macroorchidism (HP:0000053)2.17433869
102Pheochromocytoma (HP:0002666)2.14574155
103Buphthalmos (HP:0000557)2.13558816
104Hip contracture (HP:0003273)2.13260721
105Abnormality of binocular vision (HP:0011514)2.12464275
106Diplopia (HP:0000651)2.12464275
107Impaired vibratory sensation (HP:0002495)2.11256116
108Slender build (HP:0001533)2.09772545
109Generalized muscle weakness (HP:0003324)2.09493670
110Aqueductal stenosis (HP:0002410)2.09374810
111Abnormality of salivation (HP:0100755)2.08733416
112Hemiparesis (HP:0001269)2.08367160
113Asymmetric septal hypertrophy (HP:0001670)2.06332344
114Heart block (HP:0012722)2.06004991
115Scapular winging (HP:0003691)2.05587375
116Fetal akinesia sequence (HP:0001989)2.05117931
117Aplasia/Hypoplasia of the brainstem (HP:0007362)2.05010372
118Hypoplasia of the brainstem (HP:0002365)2.05010372
119Muscle stiffness (HP:0003552)2.04040151
120Blue irides (HP:0000635)2.02493579
121Intellectual disability, profound (HP:0002187)2.02466678
122Lipoatrophy (HP:0100578)2.02295667
123Akinesia (HP:0002304)2.02295631
124Abnormality of ocular smooth pursuit (HP:0000617)2.00690449
125Hyperkalemia (HP:0002153)2.00656547
126Hemiplegia (HP:0002301)2.00353414
127Focal dystonia (HP:0004373)1.99896817
128Dilated cardiomyopathy (HP:0001644)1.99809542
129Lower limb amyotrophy (HP:0007210)1.98726936
130Muscular dystrophy (HP:0003560)1.97422306
131Proximal amyotrophy (HP:0007126)1.96600894
132Papillary thyroid carcinoma (HP:0002895)1.96071939
133Pachygyria (HP:0001302)1.95528966
134Increased connective tissue (HP:0009025)1.95232704
135Insomnia (HP:0100785)1.95190725
136Mildly elevated creatine phosphokinase (HP:0008180)1.95163644
137Subacute progressive viral hepatitis (HP:0006572)1.94967218
138Obstructive sleep apnea (HP:0002870)1.94619095
139Malignant hyperthermia (HP:0002047)1.94550311
140Long clavicles (HP:0000890)1.93011948
141Polyphagia (HP:0002591)1.92639307
142Ventricular tachycardia (HP:0004756)1.92299153
143Gowers sign (HP:0003391)1.91776227
144Limited hip movement (HP:0008800)1.91542288
145Morphological abnormality of the pyramidal tract (HP:0002062)1.91509312
146Pointed chin (HP:0000307)1.91370579
147Atrial fibrillation (HP:0005110)1.90354133
148Abnormality of the ischium (HP:0003174)1.90121012
149Status epilepticus (HP:0002133)1.88828337
150Ankyloglossia (HP:0010296)1.88213803
151Open mouth (HP:0000194)1.87190048
152Exotropia (HP:0000577)1.85529527
153Clonus (HP:0002169)1.84767507
154Neuroendocrine neoplasm (HP:0100634)1.83410507
155Craniofacial dystonia (HP:0012179)1.82370915
156Generalized myoclonic seizures (HP:0002123)1.79636498
157Abnormal atrioventricular conduction (HP:0005150)1.79134889
158Apathy (HP:0000741)1.77096556
159Abnormality of the shoulder girdle musculature (HP:0001435)1.76635931
160Retinal dysplasia (HP:0007973)1.76249844
161Syncope (HP:0001279)1.73037063
162Steppage gait (HP:0003376)1.72292662
163Primary atrial arrhythmia (HP:0001692)1.70864817
164Limb-girdle muscle weakness (HP:0003325)1.69068909
165Distal lower limb muscle weakness (HP:0009053)1.69011072
166Abnormality of the hip-girdle musculature (HP:0001445)1.66863075
167Abnormality of the musculature of the pelvis (HP:0001469)1.66863075
168Limb-girdle muscle atrophy (HP:0003797)1.66367362
169Spinal rigidity (HP:0003306)1.62465033
170Prolonged QT interval (HP:0001657)1.61119969
171Hypoplastic ischia (HP:0003175)1.58559269
172Ulnar deviation of finger (HP:0009465)1.57386827
173Abnormality of the foot musculature (HP:0001436)1.56421379
174Supraventricular tachycardia (HP:0004755)1.55782468
175Supraventricular arrhythmia (HP:0005115)1.53609203
176Left ventricular hypertrophy (HP:0001712)1.53440495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.36173604
2MARK15.41564775
3NTRK33.65899361
4MAP3K93.50678786
5MAP3K43.02455391
6EPHA43.01525687
7TTN2.97723084
8MINK12.69837743
9NTRK22.32161339
10MAP2K72.19644386
11PAK62.14679389
12KSR11.94155116
13MAP2K41.93025012
14DAPK21.91840048
15PNCK1.82056937
16PHKG11.81409184
17PHKG21.81409184
18KSR21.79296001
19CAMKK11.65866246
20PIK3CG1.65085630
21NTRK11.62924406
22LATS21.56824167
23SIK21.53783614
24MAPK131.44603482
25CDK51.42434043
26CASK1.36975507
27AKT31.36470067
28CAMK1G1.35725814
29CSNK1G21.35610541
30PRKD31.29110772
31PLK21.29019213
32MAP3K121.25954468
33LATS11.24487489
34MAP3K21.17747722
35FGFR21.12384035
36BMPR1B1.11913762
37RET1.11703516
38TYRO31.08459101
39PAK31.06594220
40PRKCG1.06299791
41STK381.03722637
42RIPK41.03141264
43CCNB11.02134003
44FES1.01742555
45MARK20.97668920
46STK110.96816914
47DAPK10.95242037
48UHMK10.94487023
49RIPK10.93996750
50TNIK0.90850266
51GRK50.89281628
52ERBB30.88153999
53SGK20.85323853
54CAMKK20.84246164
55SGK30.83376719
56SGK2230.82543900
57SGK4940.82543900
58CAMK2A0.82054670
59PRKCH0.81540880
60SCYL20.80531308
61PIK3CA0.80387005
62CSNK1A1L0.79950975
63EPHA30.79754717
64TAOK10.79405340
65LMTK20.78073989
66CSNK1G30.76463992
67CAMK10.76066668
68DYRK1A0.75871131
69MAP3K70.75015728
70SGK10.73384080
71FRK0.73189328
72PRKAA20.72694554
73PRKCZ0.72194403
74ALK0.71967947
75CDK180.71520011
76NEK90.71167257
77CDK150.69517869
78CDK140.69280875
79TRPM70.68397439
80MAP4K20.67439111
81PRPF4B0.66648228
82MUSK0.64713369
83OXSR10.64464685
84FER0.62698165
85CAMK2G0.62372428
86ACVR1B0.62081070
87PRKG10.58891606
88DYRK20.58686103
89CDK11A0.56673572
90PKN10.56503471
91STK38L0.56251668
92MAPK120.56248787
93PDK10.55256811
94DMPK0.54444268
95CSNK1G10.53077885
96STK390.52926949
97PDGFRA0.52825093
98MKNK20.52699067
99RAF10.52571036
100CAMK2D0.52369415
101FYN0.51979670
102CAMK2B0.51864986
103PRKCE0.51587284
104MAP3K60.51268794
105BCR0.51123806
106TIE10.50805477
107RPS6KA20.50701390
108CDK190.50534159
109RPS6KA30.50250661
110MAP2K10.50182515
111ROCK10.48349555
112PDPK10.46793310
113NEK10.45844311
114WNK30.44750541
115MAPK100.44210649
116CAMK1D0.43630594
117WNK10.42223388
118CAMK40.42099453
119PRKACB0.41987721
120PINK10.41635696
121LIMK10.41600987
122PRKACA0.40011990
123PDK30.38212577
124PDK40.38212577
125CDC42BPA0.37075572
126CSNK1D0.36817149
127RPS6KB10.36326296
128PRKAA10.36024854
129MAP3K10.35679275
130BRD40.35675395
131PTK2B0.34221393
132MAP3K100.34107314
133MAPK70.32161193
134MAPK40.31626265
135TRIM280.30530923

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.19206297
2Synaptic vesicle cycle_Homo sapiens_hsa047212.61733345
3Circadian entrainment_Homo sapiens_hsa047132.46896827
4Long-term potentiation_Homo sapiens_hsa047202.42391992
5GABAergic synapse_Homo sapiens_hsa047272.40341167
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.31812116
7Glutamatergic synapse_Homo sapiens_hsa047242.28044561
8Olfactory transduction_Homo sapiens_hsa047402.24460544
9Amphetamine addiction_Homo sapiens_hsa050312.16227234
10Morphine addiction_Homo sapiens_hsa050322.14504962
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08821938
12Dopaminergic synapse_Homo sapiens_hsa047282.06377915
13Salivary secretion_Homo sapiens_hsa049701.91897839
14Cholinergic synapse_Homo sapiens_hsa047251.84069313
15Insulin secretion_Homo sapiens_hsa049111.79089927
16Renin secretion_Homo sapiens_hsa049241.75640723
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72995525
18Gastric acid secretion_Homo sapiens_hsa049711.69960157
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62624564
20Long-term depression_Homo sapiens_hsa047301.61690989
21Oxytocin signaling pathway_Homo sapiens_hsa049211.57641322
22Cocaine addiction_Homo sapiens_hsa050301.52106935
23Propanoate metabolism_Homo sapiens_hsa006401.45403502
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44661218
25Serotonergic synapse_Homo sapiens_hsa047261.44641196
26Taste transduction_Homo sapiens_hsa047421.43310103
27Nitrogen metabolism_Homo sapiens_hsa009101.38845835
28Axon guidance_Homo sapiens_hsa043601.38802446
29GnRH signaling pathway_Homo sapiens_hsa049121.35731012
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35404734
31Gap junction_Homo sapiens_hsa045401.35181323
32Type II diabetes mellitus_Homo sapiens_hsa049301.34034754
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33590939
34Calcium signaling pathway_Homo sapiens_hsa040201.32736766
35Glioma_Homo sapiens_hsa052141.28732010
36Estrogen signaling pathway_Homo sapiens_hsa049151.23149886
37cAMP signaling pathway_Homo sapiens_hsa040241.20427625
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19043235
39ErbB signaling pathway_Homo sapiens_hsa040121.17376401
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15862084
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11660093
42Melanogenesis_Homo sapiens_hsa049161.07693110
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07430765
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05860474
45Dorso-ventral axis formation_Homo sapiens_hsa043200.96376243
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96132354
47Endometrial cancer_Homo sapiens_hsa052130.94284017
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93206177
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89527306
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85818246
51Fatty acid degradation_Homo sapiens_hsa000710.85028677
52mTOR signaling pathway_Homo sapiens_hsa041500.84581944
53Tight junction_Homo sapiens_hsa045300.83799208
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.83635729
55Dilated cardiomyopathy_Homo sapiens_hsa054140.82946101
56Glucagon signaling pathway_Homo sapiens_hsa049220.80748994
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.80122902
58Arginine and proline metabolism_Homo sapiens_hsa003300.78490328
59Fatty acid metabolism_Homo sapiens_hsa012120.78466819
60Choline metabolism in cancer_Homo sapiens_hsa052310.77082228
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.76724612
62Oocyte meiosis_Homo sapiens_hsa041140.74925266
63Phototransduction_Homo sapiens_hsa047440.74239187
64Thyroid hormone synthesis_Homo sapiens_hsa049180.73740334
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73445056
66Bile secretion_Homo sapiens_hsa049760.72023422
67MAPK signaling pathway_Homo sapiens_hsa040100.71727149
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71357287
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70722215
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70721496
71VEGF signaling pathway_Homo sapiens_hsa043700.70392282
72Focal adhesion_Homo sapiens_hsa045100.70108633
73Insulin signaling pathway_Homo sapiens_hsa049100.68457960
74Renal cell carcinoma_Homo sapiens_hsa052110.67426721
75Pyruvate metabolism_Homo sapiens_hsa006200.65899270
76Colorectal cancer_Homo sapiens_hsa052100.65489628
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64690029
78FoxO signaling pathway_Homo sapiens_hsa040680.64419574
79Pancreatic secretion_Homo sapiens_hsa049720.63259972
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62438391
81Butanoate metabolism_Homo sapiens_hsa006500.62157113
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61898319
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61459407
84Collecting duct acid secretion_Homo sapiens_hsa049660.60632194
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60259883
86Rap1 signaling pathway_Homo sapiens_hsa040150.59776653
87Non-small cell lung cancer_Homo sapiens_hsa052230.59766223
88Ras signaling pathway_Homo sapiens_hsa040140.59260056
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59259501
90Hippo signaling pathway_Homo sapiens_hsa043900.59159459
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59033984
92Cardiac muscle contraction_Homo sapiens_hsa042600.59024630
93Wnt signaling pathway_Homo sapiens_hsa043100.58067037
94PPAR signaling pathway_Homo sapiens_hsa033200.57635850
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.56776382
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.55567769
97beta-Alanine metabolism_Homo sapiens_hsa004100.55463093
98ECM-receptor interaction_Homo sapiens_hsa045120.55041865
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54487706
100Tryptophan metabolism_Homo sapiens_hsa003800.50926942
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49300382
102ABC transporters_Homo sapiens_hsa020100.49101555
103Alcoholism_Homo sapiens_hsa050340.48828630
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47735519
105Lysine degradation_Homo sapiens_hsa003100.47392885
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47099394
107Circadian rhythm_Homo sapiens_hsa047100.45319333
108Arginine biosynthesis_Homo sapiens_hsa002200.45221343
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45184538
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45146617
111Ovarian steroidogenesis_Homo sapiens_hsa049130.44984601
112Endocytosis_Homo sapiens_hsa041440.44887342
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44522812
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44179678
115Prion diseases_Homo sapiens_hsa050200.43939482
116AMPK signaling pathway_Homo sapiens_hsa041520.43462230
117Adherens junction_Homo sapiens_hsa045200.43355236
118Fatty acid biosynthesis_Homo sapiens_hsa000610.42878473
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42427113
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42011780
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.40605947
122Inositol phosphate metabolism_Homo sapiens_hsa005620.40493541
123Vibrio cholerae infection_Homo sapiens_hsa051100.38081355
124Insulin resistance_Homo sapiens_hsa049310.36168012
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32520718

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