ZYX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)4.53660003
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.53660003
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.36618787
4detection of other organism (GO:0098543)3.94012353
5neutrophil activation involved in immune response (GO:0002283)3.85365455
6detection of bacterium (GO:0016045)3.83965620
7Arp2/3 complex-mediated actin nucleation (GO:0034314)3.67123029
8wound healing, spreading of epidermal cells (GO:0035313)3.61531501
9negative regulation of interleukin-12 production (GO:0032695)3.59338030
10positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.57391298
11detection of external biotic stimulus (GO:0098581)3.49734298
12regulation of mast cell degranulation (GO:0043304)3.48957723
13regulation of leukocyte degranulation (GO:0043300)3.45285601
14detection of molecule of bacterial origin (GO:0032490)3.42858737
15regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.38067480
16immunoglobulin mediated immune response (GO:0016064)3.34792476
17regulation of myeloid leukocyte mediated immunity (GO:0002886)3.34579615
18response to muramyl dipeptide (GO:0032495)3.30084384
19positive regulation of natural killer cell differentiation (GO:0032825)3.28322355
20leukocyte aggregation (GO:0070486)3.22481867
21regulation of interleukin-12 biosynthetic process (GO:0045075)3.21655486
22positive regulation of interferon-alpha production (GO:0032727)3.18391606
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.18295212
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.18295212
25endodermal cell differentiation (GO:0035987)3.18108314
26leukocyte migration involved in inflammatory response (GO:0002523)3.17909577
27protein localization to endosome (GO:0036010)3.17783147
28response to peptidoglycan (GO:0032494)3.17668686
29response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.15116966
30response to host (GO:0075136)3.15116966
31response to host defenses (GO:0052200)3.15116966
32response to interferon-alpha (GO:0035455)3.13733361
33response to host immune response (GO:0052572)3.13569543
34response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.13569543
35regulation of mast cell activation involved in immune response (GO:0033006)3.12002725
36positive regulation by symbiont of host defense response (GO:0052509)3.11207952
37modulation by symbiont of host defense response (GO:0052031)3.11207952
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.11207952
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.11207952
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.11207952
41modulation by symbiont of host immune response (GO:0052553)3.11207952
42detection of biotic stimulus (GO:0009595)3.08281178
43cellular extravasation (GO:0045123)3.08040794
44negative regulation of phagocytosis (GO:0050765)3.08015244
45regulation of T-helper 2 cell differentiation (GO:0045628)3.07169274
46wound healing, spreading of cells (GO:0044319)3.02688395
47positive regulation of gamma-delta T cell activation (GO:0046645)3.01801129
48regulation of interferon-alpha production (GO:0032647)3.00774186
49platelet aggregation (GO:0070527)2.92365170
50positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.91599574
51antigen processing and presentation of endogenous antigen (GO:0019883)2.90554129
52mannose metabolic process (GO:0006013)2.87961301
53regulation of macrophage cytokine production (GO:0010935)2.86930131
54myeloid dendritic cell activation (GO:0001773)2.86609210
55type I interferon signaling pathway (GO:0060337)2.86535151
56cellular response to type I interferon (GO:0071357)2.86535151
57response to type I interferon (GO:0034340)2.86168570
58barbed-end actin filament capping (GO:0051016)2.85058866
59regulation of dendritic cell antigen processing and presentation (GO:0002604)2.84134521
60granulocyte activation (GO:0036230)2.81611835
61positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.80966086
62myeloid dendritic cell differentiation (GO:0043011)2.80898234
63positive regulation of chemokine biosynthetic process (GO:0045080)2.80709543
64neutrophil activation (GO:0042119)2.80064426
65regulation of regulated secretory pathway (GO:1903305)2.79839471
66respiratory burst (GO:0045730)2.79696867
67negative regulation of leukocyte mediated immunity (GO:0002704)2.76408127
68myeloid cell activation involved in immune response (GO:0002275)2.75119730
69response to protozoan (GO:0001562)2.72910097
70negative regulation of lymphocyte mediated immunity (GO:0002707)2.72638162
71regulation of integrin activation (GO:0033623)2.72374339
72skin morphogenesis (GO:0043589)2.71169733
73response to interferon-beta (GO:0035456)2.70704314
74regulation of gamma-delta T cell activation (GO:0046643)2.70295258
75chondrocyte proliferation (GO:0035988)2.69806463
76germinal center formation (GO:0002467)2.69166210
77actin nucleation (GO:0045010)2.68689404
78defense response to protozoan (GO:0042832)2.68022195
79macrophage activation (GO:0042116)2.67906264
80negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.67546367
81regulation of T-helper 1 cell differentiation (GO:0045625)2.66967488
82regulation of B cell receptor signaling pathway (GO:0050855)2.64390121
83B cell mediated immunity (GO:0019724)2.64263628
84positive regulation of macrophage differentiation (GO:0045651)2.64234541
85pinocytosis (GO:0006907)2.62346437
86interferon-gamma-mediated signaling pathway (GO:0060333)2.62199815
87negative regulation of cytokine production involved in immune response (GO:0002719)2.61971074
88cell adhesion mediated by integrin (GO:0033627)2.59857810
89regulation of protein heterodimerization activity (GO:0043497)2.59653582
90sequestering of actin monomers (GO:0042989)2.59329859
91protein heterotrimerization (GO:0070208)2.58821453
92angiogenesis involved in wound healing (GO:0060055)2.58667177
93regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.58551796
94cellular response to interferon-alpha (GO:0035457)2.58420797
95positive regulation of mast cell activation (GO:0033005)2.57989638
96positive regulation of Cdc42 GTPase activity (GO:0043089)2.57924342
97positive regulation of monocyte chemotaxis (GO:0090026)2.56105376
98positive regulation of receptor recycling (GO:0001921)2.56042085
99natural killer cell differentiation (GO:0001779)2.55450070
100regulation of natural killer cell differentiation (GO:0032823)2.55358872
101NIK/NF-kappaB signaling (GO:0038061)2.55293647
102mature B cell differentiation involved in immune response (GO:0002313)2.55272256
103positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.55270849
104regulation of monocyte chemotaxis (GO:0090025)2.54852729
105response to laminar fluid shear stress (GO:0034616)2.53326283
106T cell migration (GO:0072678)2.53022313
107lipopolysaccharide-mediated signaling pathway (GO:0031663)2.52942520
108regulation of superoxide anion generation (GO:0032928)2.52578431
109regulation of mast cell activation (GO:0033003)2.51439542
110leukocyte cell-cell adhesion (GO:0007159)2.51362722
111dendritic cell differentiation (GO:0097028)2.49602131
112signal complex assembly (GO:0007172)2.49426020
113positive regulation of leukocyte degranulation (GO:0043302)2.49047152
114negative regulation of interleukin-6 production (GO:0032715)2.48675021
115T cell apoptotic process (GO:0070231)2.48220154
116positive regulation of endothelial cell apoptotic process (GO:2000353)2.48185669
117regulation of T cell tolerance induction (GO:0002664)2.47660153
118modulation by symbiont of host cellular process (GO:0044068)2.47323842
119hypotonic response (GO:0006971)2.46919426
120antigen processing and presentation via MHC class Ib (GO:0002475)2.46681480
121production of molecular mediator involved in inflammatory response (GO:0002532)2.46220363
122negative regulation of type 2 immune response (GO:0002829)2.45015696
123regulation of interferon-beta biosynthetic process (GO:0045357)2.44941788
124positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.43604388
125apoptotic cell clearance (GO:0043277)2.43531243
126phagocytosis, recognition (GO:0006910)2.42539886
127positive regulation of cellular amide metabolic process (GO:0034250)2.42281335
128positive regulation of blood vessel endothelial cell migration (GO:0043536)2.41813011
129regulation of chemokine biosynthetic process (GO:0045073)2.41784455
130microglial cell activation (GO:0001774)2.41663004
131regulation of B cell differentiation (GO:0045577)2.41539679
132phagocytosis, engulfment (GO:0006911)2.40895699
133membrane raft organization (GO:0031579)2.40159929
134positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.39704416
135negative regulation of innate immune response (GO:0045824)2.39646001
136regulation of monocyte differentiation (GO:0045655)2.39228366
137* stress fiber assembly (GO:0043149)2.38945408
138megakaryocyte development (GO:0035855)2.38871460
139basement membrane organization (GO:0071711)2.38717342
140positive regulation of tumor necrosis factor production (GO:0032760)2.36736850
141amino sugar catabolic process (GO:0046348)2.36459570
142regulation of mononuclear cell migration (GO:0071675)2.36238196
143definitive hemopoiesis (GO:0060216)2.36016866
144positive regulation of mast cell activation involved in immune response (GO:0033008)2.35786836
145positive regulation of mast cell degranulation (GO:0043306)2.35786836
146regulation of type 2 immune response (GO:0002828)2.35600581
147modulation by virus of host process (GO:0019054)2.35531195
148regulation of extracellular matrix disassembly (GO:0010715)2.35112795
149regulation of type I interferon-mediated signaling pathway (GO:0060338)2.34788635
150negative regulation of erythrocyte differentiation (GO:0045647)2.34605420
151homotypic cell-cell adhesion (GO:0034109)2.34568254
152collagen fibril organization (GO:0030199)2.34290709
153regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.33478526
154response to interleukin-15 (GO:0070672)2.32852871
155positive regulation of lamellipodium assembly (GO:0010592)2.28736383
156macrophage activation involved in immune response (GO:0002281)2.28282722
157myeloid cell homeostasis (GO:0002262)2.27580636
158regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.27568144
159regulation of necroptotic process (GO:0060544)2.27169956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.02339031
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.74956512
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.67867845
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.50218944
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.35558891
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.28279846
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.97023251
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.95772152
9* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.75995218
10* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.71250963
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.68828963
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52378581
13* IRF8_27001747_Chip-Seq_BMDM_Mouse2.51460356
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50913462
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48760991
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.46303637
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.36386744
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.29748564
19* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28189358
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.24461204
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18037435
22SCL_19346495_ChIP-Seq_HPC-7_Human2.17781767
23VDR_21846776_ChIP-Seq_THP-1_Human2.17734687
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.07243486
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06579239
26MAF_26560356_Chip-Seq_TH1_Human2.04704038
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.98870801
28SPI1_23547873_ChIP-Seq_NB4_Human1.98459743
29MYC_22102868_ChIP-Seq_BL_Human1.97225663
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.96503164
31* VDR_24763502_ChIP-Seq_THP-1_Human1.93004359
32* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.90908640
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.88541467
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.84021563
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80534481
36MYB_26560356_Chip-Seq_TH2_Human1.79538433
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.78723601
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77353335
39* UTX_26944678_Chip-Seq_JUKART_Human1.71215955
40TCF7_22412390_ChIP-Seq_EML_Mouse1.69614624
41* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67479374
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66864696
43* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61095650
44* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.60848337
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60196782
46* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54823966
47MYB_26560356_Chip-Seq_TH1_Human1.52776894
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51646315
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.50503988
50SPI1_23127762_ChIP-Seq_K562_Human1.47056473
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46347110
52KDM2B_26808549_Chip-Seq_JURKAT_Human1.46259898
53KDM2B_26808549_Chip-Seq_K562_Human1.46258184
54* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45582846
55RUNX_20019798_ChIP-Seq_JUKART_Human1.45521452
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40442563
57* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39627653
58* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39449080
59E2F7_22180533_ChIP-Seq_HELA_Human1.39253254
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38411953
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37946764
62ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.37419440
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32294593
64KDM2B_26808549_Chip-Seq_DND41_Human1.31907647
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30088360
66* GATA1_19941827_ChIP-Seq_MEL_Mouse1.30007035
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29396402
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29367429
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.29085097
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29073168
71SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28733214
72SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28733214
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25455194
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23921167
75CLOCK_20551151_ChIP-Seq_293T_Human1.23793287
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23571990
77PU_27001747_Chip-Seq_BMDM_Mouse1.22709206
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19339400
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18749910
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16902227
81PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16479660
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16189137
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16087781
84* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15333794
85ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14501142
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14456209
87* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14373001
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14291245
89NCOR1_26117541_ChIP-Seq_K562_Human1.13155006
90* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12913400
91* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12544427
92* LXR_22292898_ChIP-Seq_THP-1_Human1.12362173
93GATA1_19941826_ChIP-Seq_K562_Human1.12192888
94MAF_26560356_Chip-Seq_TH2_Human1.11835692
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11258925
96ESR2_21235772_ChIP-Seq_MCF-7_Human1.11201025
97P68_20966046_ChIP-Seq_HELA_Human1.11174261
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.10083214
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09862405
100* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09831956
101GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09197217
102SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09158519
103TET1_21451524_ChIP-Seq_MESCs_Mouse1.08643567
104BCL6_27268052_Chip-Seq_Bcells_Human1.08005128
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07862165
106ATF3_27146783_Chip-Seq_COLON_Human1.07781741
107ELF1_20517297_ChIP-Seq_JURKAT_Human1.07616659
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07383724
109GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07143295
110BCOR_27268052_Chip-Seq_Bcells_Human1.06040902
111IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05809809
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05310034
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05086919
114PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05031091
115SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04026988
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03942488
117* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02943966
118* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02403271
119* RACK7_27058665_Chip-Seq_MCF-7_Human1.01218905
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01109916
121* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01107975
122NOTCH1_21737748_ChIP-Seq_TLL_Human0.97845075
123* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97662126
124TFEB_21752829_ChIP-Seq_HELA_Human0.94895366
125JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93054580
126PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92562347
127CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92372564
128VDR_24787735_ChIP-Seq_THP-1_Human0.91524993
129BRD4_25478319_ChIP-Seq_HGPS_Human0.90336583
130TP53_22127205_ChIP-Seq_IMR90_Human0.90151261
131UBF1/2_26484160_Chip-Seq_HMECs_Human0.89606915

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.71967475
2MP0003436_decreased_susceptibility_to3.07985102
3MP0003279_aneurysm2.88656236
4MP0001835_abnormal_antigen_presentation2.79793960
5MP0009785_altered_susceptibility_to2.66930626
6MP0003191_abnormal_cellular_cholesterol2.45923278
7MP0003303_peritoneal_inflammation2.37791590
8MP0003705_abnormal_hypodermis_morpholog2.27093010
9MP0002148_abnormal_hypersensitivity_rea2.22401454
10MP0000685_abnormal_immune_system2.20879894
11MP0002419_abnormal_innate_immunity2.13339182
12MP0003172_abnormal_lysosome_physiology2.11924600
13MP0005000_abnormal_immune_tolerance2.08862588
14MP0006054_spinal_hemorrhage2.07407723
15MP0005025_abnormal_response_to2.05515771
16MP0003724_increased_susceptibility_to2.04669609
17MP0008260_abnormal_autophagy2.02585332
18MP0010352_gastrointestinal_tract_polyps1.95574078
19MP0001958_emphysema1.94598816
20MP0005503_abnormal_tendon_morphology1.93369028
21MP0005671_abnormal_response_to1.92011580
22MP0005023_abnormal_wound_healing1.90297532
23MP0001533_abnormal_skeleton_physiology1.89800403
24MP0002452_abnormal_antigen_presenting1.89047896
25MP0000858_altered_metastatic_potential1.85952730
26* MP0003566_abnormal_cell_adhesion1.84573733
27MP0006082_CNS_inflammation1.80822782
28MP0005464_abnormal_platelet_physiology1.80184552
29MP0009278_abnormal_bone_marrow1.78761662
30MP0005275_abnormal_skin_tensile1.78707539
31MP0000343_altered_response_to1.78344819
32MP0001853_heart_inflammation1.78114551
33MP0004808_abnormal_hematopoietic_stem1.75482293
34MP0009333_abnormal_splenocyte_physiolog1.74608645
35MP0002396_abnormal_hematopoietic_system1.74565367
36MP0003448_altered_tumor_morphology1.74126726
37MP0001790_abnormal_immune_system1.73908169
38MP0005387_immune_system_phenotype1.73908169
39MP0002405_respiratory_system_inflammati1.71847286
40MP0002723_abnormal_immune_serum1.68573417
41MP0001819_abnormal_immune_cell1.67414147
42MP0001800_abnormal_humoral_immune1.66979032
43MP0002420_abnormal_adaptive_immunity1.66202761
44MP0005451_abnormal_body_composition1.65233190
45MP0004510_myositis1.56527092
46MP0004272_abnormal_basement_membrane1.56033831
47MP0005397_hematopoietic_system_phenotyp1.55869112
48MP0001545_abnormal_hematopoietic_system1.55869112
49MP0002933_joint_inflammation1.55427760
50MP0001849_ear_inflammation1.50578817
51MP0003300_gastrointestinal_ulcer1.50166056
52MP0004858_abnormal_nervous_system1.47802142
53MP0003828_pulmonary_edema1.46180221
54MP0010155_abnormal_intestine_physiology1.46036364
55MP0005623_abnormal_meninges_morphology1.42203711
56MP0004947_skin_inflammation1.42059446
57MP0005390_skeleton_phenotype1.41755102
58MP0000767_abnormal_smooth_muscle1.41344261
59* MP0003091_abnormal_cell_migration1.39491016
60MP0010368_abnormal_lymphatic_system1.37479273
61MP0002398_abnormal_bone_marrow1.35589064
62MP0001845_abnormal_inflammatory_respons1.26904142
63MP0000716_abnormal_immune_system1.25036114
64MP0002998_abnormal_bone_remodeling1.24151493
65MP0000733_abnormal_muscle_development1.22864601
66MP0005058_abnormal_lysosome_morphology1.17400456
67MP0002722_abnormal_immune_system1.12244290
68MP0002429_abnormal_blood_cell1.11645546
69MP0000689_abnormal_spleen_morphology1.10289801
70MP0001879_abnormal_lymphatic_vessel1.10057952
71MP0008007_abnormal_cellular_replicative1.08965363
72MP0000465_gastrointestinal_hemorrhage1.07409635
73MP0000490_abnormal_crypts_of1.06838763
74MP0003763_abnormal_thymus_physiology1.06192595
75MP0002166_altered_tumor_susceptibility1.04690617
76MP0001542_abnormal_bone_strength1.04342700
77MP0002060_abnormal_skin_morphology1.04029989
78MP0008004_abnormal_stomach_pH1.03256258
79MP0002877_abnormal_melanocyte_morpholog1.02594541
80MP0009764_decreased_sensitivity_to1.02152662
81MP0002006_tumorigenesis1.01473229
82MP0005508_abnormal_skeleton_morphology1.01153750
83MP0001243_abnormal_dermal_layer1.00726975
84MP0008469_abnormal_protein_level0.99741293
85MP0009384_cardiac_valve_regurgitation0.99325130
86MP0001348_abnormal_lacrimal_gland0.98480753
87MP0000604_amyloidosis0.96595387
88MP0002254_reproductive_system_inflammat0.92803363
89MP0000249_abnormal_blood_vessel0.91378790
90MP0003795_abnormal_bone_structure0.90811988
91MP0003183_abnormal_peptide_metabolism0.88878531
92MP0005076_abnormal_cell_differentiation0.86681608
93MP0005164_abnormal_response_to0.86303056
94MP0003866_abnormal_defecation0.85167573
95MP0005257_abnormal_intraocular_pressure0.84728107
96MP0003045_fibrosis0.82622547
97MP0001851_eye_inflammation0.82258278
98MP0000703_abnormal_thymus_morphology0.81744123
99MP0001614_abnormal_blood_vessel0.80413739
100MP0002128_abnormal_blood_circulation0.78934006
101MP0005166_decreased_susceptibility_to0.78293071
102MP0001915_intracranial_hemorrhage0.77001625
103MP0004883_abnormal_blood_vessel0.76913393
104MP0009840_abnormal_foam_cell0.76682513
105MP0003453_abnormal_keratinocyte_physiol0.75595853
106MP0003075_altered_response_to0.74110518
107MP0003329_amyloid_beta_deposits0.73212952
108MP0002132_abnormal_respiratory_system0.73108156
109MP0005409_darkened_coat_color0.73028567
110MP0001663_abnormal_digestive_system0.72964327
111MP0005595_abnormal_vascular_smooth0.72311770
112MP0010030_abnormal_orbit_morphology0.72098004
113MP0009763_increased_sensitivity_to0.69693981
114MP0002113_abnormal_skeleton_development0.69205516
115MP0005310_abnormal_salivary_gland0.69080702
116MP0001175_abnormal_lung_morphology0.66235313

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.51097740
2Premature rupture of membranes (HP:0001788)4.74688433
3Recurrent abscess formation (HP:0002722)4.32029784
4Eczematoid dermatitis (HP:0000976)4.25758376
5Peritonitis (HP:0002586)4.09793890
6Elevated erythrocyte sedimentation rate (HP:0003565)3.85010419
7Recurrent bacterial skin infections (HP:0005406)3.68766289
8Vertebral compression fractures (HP:0002953)3.59147862
9Myositis (HP:0100614)3.54691148
10Aortic dissection (HP:0002647)3.34259717
11Cervical subluxation (HP:0003308)3.07280311
12Dilatation of the ascending aorta (HP:0005111)2.96188287
13Orchitis (HP:0100796)2.95819647
14Cerebral aneurysm (HP:0004944)2.91138744
15Spinal cord lesions (HP:0100561)2.87502013
16Syringomyelia (HP:0003396)2.87502013
17Aortic aneurysm (HP:0004942)2.86604219
18Recurrent gram-negative bacterial infections (HP:0005420)2.85742940
19Biconcave vertebral bodies (HP:0004586)2.85597353
20Cellulitis (HP:0100658)2.85341746
21Abnormality of glycolipid metabolism (HP:0010969)2.83927581
22Abnormality of liposaccharide metabolism (HP:0010968)2.83927581
23Abnormality of glycosphingolipid metabolism (HP:0004343)2.83927581
24Shallow orbits (HP:0000586)2.83488423
25Abnormality of macrophages (HP:0004311)2.80467997
26Osteolytic defects of the hand bones (HP:0009699)2.72746849
27Osteolytic defects of the phalanges of the hand (HP:0009771)2.72746849
28Ankle contracture (HP:0006466)2.69683774
29Mediastinal lymphadenopathy (HP:0100721)2.68250243
30Dysostosis multiplex (HP:0000943)2.63855284
31Atrophic scars (HP:0001075)2.52718239
32Stomatitis (HP:0010280)2.51304760
33Abnormal platelet volume (HP:0011876)2.50800600
34Increased density of long bones (HP:0006392)2.46921676
35Increased IgE level (HP:0003212)2.46841954
36Recurrent fungal infections (HP:0002841)2.44976531
37Increased variability in muscle fiber diameter (HP:0003557)2.44045112
38Petechiae (HP:0000967)2.41923419
39Recurrent skin infections (HP:0001581)2.40236754
40Increased mean platelet volume (HP:0011877)2.39563422
41Amyloidosis (HP:0011034)2.38137120
42Vacuolated lymphocytes (HP:0001922)2.35470078
43Increased cerebral lipofuscin (HP:0011813)2.34707584
44Soft skin (HP:0000977)2.34490717
45Thrombocytosis (HP:0001894)2.34425746
46Wormian bones (HP:0002645)2.30465200
47Abnormality of the peritoneum (HP:0002585)2.28921978
48Obstructive lung disease (HP:0006536)2.27577978
49Chronic obstructive pulmonary disease (HP:0006510)2.27577978
50Abnormality of skeletal muscle fiber size (HP:0012084)2.27207412
51Increased neuronal autofluorescent lipopigment (HP:0002074)2.26732882
52Broad face (HP:0000283)2.26245066
53Gastrointestinal infarctions (HP:0005244)2.24741050
54Loss of speech (HP:0002371)2.24581268
55Slender build (HP:0001533)2.24189443
56Blue sclerae (HP:0000592)2.23521653
57Interstitial pulmonary disease (HP:0006530)2.18143397
58Abnormality of polysaccharide metabolism (HP:0011012)2.17740216
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.17740216
60Abnormality of mucopolysaccharide metabolism (HP:0011020)2.17740216
61Nonimmune hydrops fetalis (HP:0001790)2.16161813
62Fragile skin (HP:0001030)2.15582978
63Optic neuritis (HP:0100653)2.15524965
64Retrobulbar optic neuritis (HP:0100654)2.15524965
65Bladder diverticulum (HP:0000015)2.15413991
66Mitral valve prolapse (HP:0001634)2.14385796
67Meningitis (HP:0001287)2.14289398
68Broad metatarsal (HP:0001783)2.12457850
69Genu recurvatum (HP:0002816)2.10529445
70Mucopolysacchariduria (HP:0008155)2.09859594
71Urinary glycosaminoglycan excretion (HP:0003541)2.09859594
72Polycythemia (HP:0001901)2.09674787
73Disproportionate tall stature (HP:0001519)2.09475122
74Spontaneous hematomas (HP:0007420)2.09455890
75Distal lower limb muscle weakness (HP:0009053)2.09334268
76Abnormality of the calcaneus (HP:0008364)2.08413970
77Chronic otitis media (HP:0000389)2.08273556
78Distal lower limb amyotrophy (HP:0008944)2.08133265
79Increased connective tissue (HP:0009025)2.08103562
80Spinal rigidity (HP:0003306)2.05832482
81Prolonged bleeding time (HP:0003010)2.05636809
82Autoimmune thrombocytopenia (HP:0001973)2.04952343
83Gingivitis (HP:0000230)2.03958811
84Spondylolisthesis (HP:0003302)2.03816284
85Thin bony cortex (HP:0002753)2.03736739
86Episodic fever (HP:0001954)2.03120431
87Aneurysm (HP:0002617)2.02794881
88Hepatosplenomegaly (HP:0001433)2.02446539
89Gingival bleeding (HP:0000225)2.01878371
90Arterial thrombosis (HP:0004420)2.01532719
91Chest pain (HP:0100749)1.98830266
92Arterial tortuosity (HP:0005116)1.95843740
93Recurrent viral infections (HP:0004429)1.95635471
94Abnormality of the acetabulum (HP:0003170)1.93233683
95Impaired platelet aggregation (HP:0003540)1.92497687
96Abnormal platelet function (HP:0011869)1.92497687
97Chronic mucocutaneous candidiasis (HP:0002728)1.92377349
98Recurrent cutaneous fungal infections (HP:0011370)1.92377349
99Systemic lupus erythematosus (HP:0002725)1.92371752
100Abnormal delayed hypersensitivity skin test (HP:0002963)1.91306651
101Obstructive sleep apnea (HP:0002870)1.90379246
102Abnormality of the pericardium (HP:0001697)1.90204354
103Abnormality of dentin (HP:0010299)1.90138798
104Elbow flexion contracture (HP:0002987)1.89728446
105Upper motor neuron abnormality (HP:0002127)1.88975103
106Epistaxis (HP:0000421)1.88216711
107Vasculitis (HP:0002633)1.87561784
108Beaking of vertebral bodies (HP:0004568)1.87319391
109Joint stiffness (HP:0001387)1.86459815
110Polygenic inheritance (HP:0010982)1.86147105
111Leukocytosis (HP:0001974)1.85704807
112Myocardial infarction (HP:0001658)1.85202668
113Flexion contracture of toe (HP:0005830)1.84334638
114Joint contractures involving the joints of the feet (HP:0100492)1.84334638
115Basal ganglia calcification (HP:0002135)1.84305832
116Bilateral sensorineural hearing impairment (HP:0008619)1.83640382
117Axonal loss (HP:0003447)1.83559000
118Acrocyanosis (HP:0001063)1.83550118
119Camptodactyly of toe (HP:0001836)1.82647316
120Achilles tendon contracture (HP:0001771)1.82383029
121Mitral regurgitation (HP:0001653)1.81961851
122Radial bowing (HP:0002986)1.81871529
123Short nail (HP:0001799)1.81660650
124Menorrhagia (HP:0000132)1.81602513
125Purpura (HP:0000979)1.80599067
126Bruising susceptibility (HP:0000978)1.80477189
127Pulmonary infiltrates (HP:0002113)1.80303725
128Hematochezia (HP:0002573)1.80053069
129Abnormality of the nasal mucosa (HP:0000433)1.79486809
130Type 1 muscle fiber predominance (HP:0003803)1.78993595
131Emphysema (HP:0002097)1.76888422
132Poor head control (HP:0002421)1.76478534
133Upper limb amyotrophy (HP:0009129)1.76327276
134Distal upper limb amyotrophy (HP:0007149)1.76327276
135Gastrointestinal inflammation (HP:0004386)1.74243713
136Increased serum ferritin (HP:0003281)1.73874368
137Urticaria (HP:0001025)1.73692420
138Persistence of primary teeth (HP:0006335)1.73428224
139Hypertriglyceridemia (HP:0002155)1.73369403
140Centrally nucleated skeletal muscle fibers (HP:0003687)1.73365860
141Neonatal short-limb short stature (HP:0008921)1.72819610
142Vascular tortuosity (HP:0004948)1.72735065
143Hemoptysis (HP:0002105)1.72723656
144Coxa vara (HP:0002812)1.72389895

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN12.95014372
2PIM22.81057420
3PRPF4B2.80102305
4TRIB32.70195816
5TTN2.61582793
6TBK12.56941267
7MAP4K12.38257628
8NME22.35121092
9KIT2.22927105
10MAP3K142.11147730
11RPS6KA42.09096570
12PKN21.98553289
13BLK1.97579525
14SMG11.92873458
15MAP2K31.90620205
16EPHB11.89201346
17JAK31.88558805
18IRAK41.75077323
19BTK1.73524816
20MAP3K101.69289105
21KDR1.68259758
22TYK21.64182976
23TRPM71.64031262
24PRKD21.58428617
25FES1.57199885
26TEC1.53469972
27IKBKB1.51872566
28PAK41.51368730
29TGFBR21.50945535
30ZAP701.47526148
31LRRK21.45515365
32RIPK11.44604728
33BMX1.44454934
34TGFBR11.43460594
35STK101.42756661
36TNK21.42415694
37GRK61.41788188
38IRAK31.39138875
39IKBKE1.37840315
40EEF2K1.35818896
41TXK1.35518217
42FLT31.34806291
43NEK91.34557599
44TESK11.31150537
45CDC42BPA1.27177641
46MAP3K131.25063215
47CSF1R1.25042048
48PTK61.22967202
49MYLK1.20903696
50ICK1.19295391
51TESK21.18386655
52MAP3K11.18042318
53CSK1.15385173
54HCK1.13129724
55FGR1.10437234
56MAP3K61.10430395
57ILK1.10340374
58MARK21.09999828
59EPHA31.08703337
60DMPK1.08417759
61KSR21.07981659
62CLK11.07545954
63CDK191.06971901
64CHUK1.05983797
65ITK1.05623970
66MAP3K111.01754660
67PIM11.01091064
68PAK20.96455749
69MAP3K30.94832738
70MOS0.93630488
71PTK20.91731051
72PIK3CG0.89939389
73FGFR40.89413829
74JAK10.88100404
75DDR20.87184796
76TIE10.85797515
77PDPK10.85151626
78RPS6KA20.84681402
79ABL20.83035998
80PRKG20.82294495
81EPHB20.81965847
82LCK0.77207524
83STK380.76912677
84PTK2B0.71392435
85DAPK30.71266856
86MATK0.70990530
87PDGFRA0.70332752
88ARAF0.66407559
89MAPK70.65466434
90LATS20.64547707
91MAPKAPK20.63488481
92EPHA20.63404680
93CDK120.62816660
94LIMK10.62162920
95JAK20.60842031
96MAP3K70.60822063
97STK40.60698030
98SYK0.60651480
99IRAK20.59764647
100HIPK20.58983670
101PDK10.58927330
102TAOK10.58757990
103LYN0.57800606
104SIK30.56485112
105NLK0.55986396
106TAOK20.55619891
107TLK10.55358757
108GRK70.54437669
109RPS6KA60.54071608
110CDK60.53152575
111LMTK20.52066988
112MAP3K80.51841539
113MAPK120.51654236
114FGFR30.49091538
115RIPK40.48962079
116MARK30.46673724
117FYN0.46650045
118PAK10.45590025
119PBK0.45274648
120MTOR0.43030903
121DYRK1B0.42511780
122SIK10.41725211
123SIK20.41015531
124ABL10.39754818
125CDK70.38839953
126RPS6KC10.38773029
127RPS6KL10.38773029
128RPS6KB20.38418855
129PDGFRB0.37976369
130MAP2K20.35437037
131MAP3K120.34706910
132ERBB30.33596814

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.95120508
2Malaria_Homo sapiens_hsa051442.22819964
3Shigellosis_Homo sapiens_hsa051312.13278357
4Osteoclast differentiation_Homo sapiens_hsa043801.95417860
5NF-kappa B signaling pathway_Homo sapiens_hsa040641.95063681
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94035905
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.91454230
8Graft-versus-host disease_Homo sapiens_hsa053321.89296752
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.87740233
10Legionellosis_Homo sapiens_hsa051341.82778740
11Measles_Homo sapiens_hsa051621.81035803
12Leukocyte transendothelial migration_Homo sapiens_hsa046701.79889074
13Pertussis_Homo sapiens_hsa051331.79320990
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77249441
15Viral myocarditis_Homo sapiens_hsa054161.73345903
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.72288997
17TNF signaling pathway_Homo sapiens_hsa046681.70805067
18Salmonella infection_Homo sapiens_hsa051321.68605561
19Toxoplasmosis_Homo sapiens_hsa051451.68151393
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.62886546
21Caffeine metabolism_Homo sapiens_hsa002321.62725149
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62720835
23Hematopoietic cell lineage_Homo sapiens_hsa046401.62304371
24Allograft rejection_Homo sapiens_hsa053301.61479226
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.58892612
26Apoptosis_Homo sapiens_hsa042101.52844062
27Antigen processing and presentation_Homo sapiens_hsa046121.52511654
28ECM-receptor interaction_Homo sapiens_hsa045121.46712463
29Tuberculosis_Homo sapiens_hsa051521.46601216
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46135529
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.44459085
32Staphylococcus aureus infection_Homo sapiens_hsa051501.44386496
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42018031
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.41709558
35Amoebiasis_Homo sapiens_hsa051461.40779516
36Platelet activation_Homo sapiens_hsa046111.40187842
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37961219
38B cell receptor signaling pathway_Homo sapiens_hsa046621.37476472
39* Focal adhesion_Homo sapiens_hsa045101.36155858
40Herpes simplex infection_Homo sapiens_hsa051681.34224758
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32196168
42Chronic myeloid leukemia_Homo sapiens_hsa052201.31803996
43Hepatitis B_Homo sapiens_hsa051611.27076391
44Influenza A_Homo sapiens_hsa051641.27057556
45Acute myeloid leukemia_Homo sapiens_hsa052211.24832477
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24620231
47Small cell lung cancer_Homo sapiens_hsa052221.24064033
48Proteoglycans in cancer_Homo sapiens_hsa052051.20943875
49Primary immunodeficiency_Homo sapiens_hsa053401.20059871
50Non-small cell lung cancer_Homo sapiens_hsa052231.17708785
51Phagosome_Homo sapiens_hsa041451.11343190
52Rheumatoid arthritis_Homo sapiens_hsa053231.05573107
53Lysosome_Homo sapiens_hsa041421.03953027
54Chemokine signaling pathway_Homo sapiens_hsa040621.03210301
55Asthma_Homo sapiens_hsa053101.03063610
56Adherens junction_Homo sapiens_hsa045201.00122004
57Renal cell carcinoma_Homo sapiens_hsa052110.99680465
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97484725
59HTLV-I infection_Homo sapiens_hsa051660.96339247
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.96012735
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.95915298
62Pancreatic cancer_Homo sapiens_hsa052120.95062423
63p53 signaling pathway_Homo sapiens_hsa041150.94977235
64Bladder cancer_Homo sapiens_hsa052190.93950972
65Other glycan degradation_Homo sapiens_hsa005110.93260878
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89480823
67Ribosome_Homo sapiens_hsa030100.89037564
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86954318
69MicroRNAs in cancer_Homo sapiens_hsa052060.86298908
70Hepatitis C_Homo sapiens_hsa051600.83731260
71Prion diseases_Homo sapiens_hsa050200.81816277
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81416974
73T cell receptor signaling pathway_Homo sapiens_hsa046600.79890257
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.79643122
75Viral carcinogenesis_Homo sapiens_hsa052030.79161097
76African trypanosomiasis_Homo sapiens_hsa051430.79147173
77Endometrial cancer_Homo sapiens_hsa052130.78366564
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76116569
79GnRH signaling pathway_Homo sapiens_hsa049120.74888818
80HIF-1 signaling pathway_Homo sapiens_hsa040660.74639508
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.73650841
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73020143
83Epstein-Barr virus infection_Homo sapiens_hsa051690.72805656
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69660805
85Pentose phosphate pathway_Homo sapiens_hsa000300.69129347
86Notch signaling pathway_Homo sapiens_hsa043300.67200872
87Galactose metabolism_Homo sapiens_hsa000520.65439375
88Glioma_Homo sapiens_hsa052140.62570900
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62493924
90Vibrio cholerae infection_Homo sapiens_hsa051100.61976175
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61812018
92TGF-beta signaling pathway_Homo sapiens_hsa043500.61619288
93Prolactin signaling pathway_Homo sapiens_hsa049170.60397231
94VEGF signaling pathway_Homo sapiens_hsa043700.59092831
95Choline metabolism in cancer_Homo sapiens_hsa052310.58328611
96mTOR signaling pathway_Homo sapiens_hsa041500.57965504
97Estrogen signaling pathway_Homo sapiens_hsa049150.57733616
98MAPK signaling pathway_Homo sapiens_hsa040100.56914982
99ErbB signaling pathway_Homo sapiens_hsa040120.56370472
100Pathways in cancer_Homo sapiens_hsa052000.53739822
101Dilated cardiomyopathy_Homo sapiens_hsa054140.53365442
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52818033
103Rap1 signaling pathway_Homo sapiens_hsa040150.52808968
104Insulin signaling pathway_Homo sapiens_hsa049100.52298117
105Autoimmune thyroid disease_Homo sapiens_hsa053200.49475306
106Base excision repair_Homo sapiens_hsa034100.48965821
107Renin-angiotensin system_Homo sapiens_hsa046140.46818590
108DNA replication_Homo sapiens_hsa030300.46282677
109Prostate cancer_Homo sapiens_hsa052150.45392715
110Endocytosis_Homo sapiens_hsa041440.44228790
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43321188
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40997992
113Thyroid cancer_Homo sapiens_hsa052160.39477100
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.39095610
115Type I diabetes mellitus_Homo sapiens_hsa049400.39049069
116Colorectal cancer_Homo sapiens_hsa052100.38659362
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.38145478
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37093246
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35924020
120Melanoma_Homo sapiens_hsa052180.35829541
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35002997

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