ZZEF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of protein polyubiquitination (GO:1902914)4.65030199
2SMAD protein complex assembly (GO:0007183)4.24205953
3histone H3-K4 trimethylation (GO:0080182)4.03811776
4regulation of autophagic vacuole assembly (GO:2000785)4.03511910
5centrosome localization (GO:0051642)4.02889435
6keratinocyte development (GO:0003334)3.84465825
7positive regulation of insulin receptor signaling pathway (GO:0046628)3.82055588
8activated T cell proliferation (GO:0050798)3.67732767
9intestinal cholesterol absorption (GO:0030299)3.52171732
10regulation of vacuole organization (GO:0044088)3.45838458
11mannose metabolic process (GO:0006013)3.37008995
12positive regulation of gamma-delta T cell activation (GO:0046645)3.35384479
13negative regulation of gluconeogenesis (GO:0045721)3.34231214
14intestinal absorption (GO:0050892)3.27583683
15negative regulation of erythrocyte differentiation (GO:0045647)3.24515460
16cellular extravasation (GO:0045123)3.24354245
17positive regulation of cell adhesion mediated by integrin (GO:0033630)3.04527055
18positive regulation of cellular response to insulin stimulus (GO:1900078)3.01259404
19negative regulation of granulocyte differentiation (GO:0030853)2.99636946
20detection of other organism (GO:0098543)2.98944500
21protein localization to cilium (GO:0061512)2.98749867
22negative regulation of myotube differentiation (GO:0010832)2.96931922
23histone H3-K36 demethylation (GO:0070544)2.95225838
24response to muramyl dipeptide (GO:0032495)2.90605692
25positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.89336809
26cellular response to ethanol (GO:0071361)2.87596498
27detection of bacterium (GO:0016045)2.80542247
28retrograde transport, vesicle recycling within Golgi (GO:0000301)2.76963442
29phospholipid homeostasis (GO:0055091)2.76548479
30establishment of protein localization to Golgi (GO:0072600)2.73343563
31B cell receptor signaling pathway (GO:0050853)2.71341410
32cytoplasmic mRNA processing body assembly (GO:0033962)2.69407343
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.66257805
34negative regulation of cell killing (GO:0031342)2.66257805
35negative regulation of macroautophagy (GO:0016242)2.63016769
36protein targeting to Golgi (GO:0000042)2.59406301
37histone H3-K9 demethylation (GO:0033169)2.58983997
38germinal center formation (GO:0002467)2.57184261
39detection of external biotic stimulus (GO:0098581)2.54589969
40regulation of ARF protein signal transduction (GO:0032012)2.52401820
41angiotensin maturation (GO:0002003)2.50915080
42negative regulation of translation, ncRNA-mediated (GO:0040033)2.50700068
43regulation of translation, ncRNA-mediated (GO:0045974)2.50700068
44negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.50700068
45leukocyte aggregation (GO:0070486)2.50667735
46macroautophagy (GO:0016236)2.50598606
47lipid translocation (GO:0034204)2.50460279
48phospholipid translocation (GO:0045332)2.50460279
49regulation of gamma-delta T cell activation (GO:0046643)2.49844663
50diacylglycerol metabolic process (GO:0046339)2.49680033
51peptidyl-lysine trimethylation (GO:0018023)2.49422491
52detection of molecule of bacterial origin (GO:0032490)2.47134374
53histone H3-K4 methylation (GO:0051568)2.44979794
54positive regulation of histone deacetylation (GO:0031065)2.44605239
55positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.44035634
56negative regulation of interleukin-12 production (GO:0032695)2.43081532
57modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.42181731
58positive regulation by organism of defense response of other organism involved in symbiotic interact2.42181731
59modulation by symbiont of host immune response (GO:0052553)2.42181731
60positive regulation by symbiont of host defense response (GO:0052509)2.42181731
61modulation by symbiont of host defense response (GO:0052031)2.42181731
62modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.42181731
63histone H3-K9 modification (GO:0061647)2.41756908
64lipoprotein transport (GO:0042953)2.41335261
65response to laminar fluid shear stress (GO:0034616)2.40894647
66response to peptidoglycan (GO:0032494)2.40749778
67growth hormone receptor signaling pathway (GO:0060396)2.40040222
68relaxation of cardiac muscle (GO:0055119)2.38931448
69neutrophil activation involved in immune response (GO:0002283)2.37899292
70regulation of macroautophagy (GO:0016241)2.37826187
71synaptic vesicle endocytosis (GO:0048488)2.36741621
72positive regulation of p38MAPK cascade (GO:1900745)2.36514075
73negative regulation of cAMP-mediated signaling (GO:0043951)2.35465686
74regulation of granulocyte differentiation (GO:0030852)2.34565462
75nerve growth factor signaling pathway (GO:0038180)2.34435793
76regulation of necroptotic process (GO:0060544)2.34207234
77positive thymic T cell selection (GO:0045059)2.34203573
78regulation of interferon-beta biosynthetic process (GO:0045357)2.33825245
79positive regulation of Cdc42 GTPase activity (GO:0043089)2.33300567
80negative regulation of lymphocyte mediated immunity (GO:0002707)2.32511091
81histone lysine demethylation (GO:0070076)2.31371694
82regulation of gamma-delta T cell differentiation (GO:0045586)2.30966489
83embryonic process involved in female pregnancy (GO:0060136)2.30434642
84antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.29857950
85negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.29614178
86negative regulation of toll-like receptor signaling pathway (GO:0034122)2.28065720
87regulation of leukocyte degranulation (GO:0043300)2.26757343
88negative regulation of T cell mediated immunity (GO:0002710)2.25368049
89cellular potassium ion homeostasis (GO:0030007)2.25090160
90positive T cell selection (GO:0043368)2.24375642
91B cell homeostasis (GO:0001782)2.23758795
92macrophage activation (GO:0042116)2.23608190
93antigen processing and presentation via MHC class Ib (GO:0002475)2.21652444
94negative regulation of leukocyte mediated immunity (GO:0002704)2.21458106
95activation of JUN kinase activity (GO:0007257)2.21381641
96histone demethylation (GO:0016577)2.21295763
97regulation of interleukin-12 biosynthetic process (GO:0045075)2.21171827
98T cell migration (GO:0072678)2.19392843
99antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.19338420
100antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.19338420
101I-kappaB phosphorylation (GO:0007252)2.16548565
102antigen processing and presentation of endogenous antigen (GO:0019883)2.16271802
103response to interleukin-15 (GO:0070672)2.15492609
104positive regulation of CREB transcription factor activity (GO:0032793)2.14957292
105detection of biotic stimulus (GO:0009595)2.14914122
106regulation of defense response to virus by virus (GO:0050690)2.14739132
107suckling behavior (GO:0001967)2.14451620
108regulation of dendritic cell antigen processing and presentation (GO:0002604)2.13543697
109early endosome to late endosome transport (GO:0045022)2.12166232
110microglial cell activation (GO:0001774)2.10956886
111response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.09856674
112response to host (GO:0075136)2.09856674
113response to host defenses (GO:0052200)2.09856674
114actin filament depolymerization (GO:0030042)2.09353588
115labyrinthine layer development (GO:0060711)2.09302353
116positive regulation of protein deacetylation (GO:0090312)2.09118400
117macrophage activation involved in immune response (GO:0002281)2.08863417
118regulation of myeloid leukocyte mediated immunity (GO:0002886)2.08476975
119skeletal muscle adaptation (GO:0043501)2.08050525
120negative T cell selection (GO:0043383)2.07977759
121negative regulation of protein acetylation (GO:1901984)2.06824722
122phospholipid efflux (GO:0033700)2.06424206
123JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.05509647
124regulation of ARF GTPase activity (GO:0032312)2.05272472
125cytoskeletal anchoring at plasma membrane (GO:0007016)2.04527409
126Golgi to endosome transport (GO:0006895)2.04259070
127phosphatidylinositol dephosphorylation (GO:0046856)2.03428486
128negative thymic T cell selection (GO:0045060)2.03137599
129regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.02734170
130T cell selection (GO:0045058)2.01947794
131negative regulation of bone resorption (GO:0045779)2.01492292
132embryonic retina morphogenesis in camera-type eye (GO:0060059)2.01161649
133regulation of Rac protein signal transduction (GO:0035020)2.00711612
134nucleobase catabolic process (GO:0046113)2.00601662
135regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.00332272
136heterotypic cell-cell adhesion (GO:0034113)1.99982851
137mature B cell differentiation (GO:0002335)1.99697837
138muscle atrophy (GO:0014889)1.99245330
139cellular response to growth hormone stimulus (GO:0071378)1.98132911
140sodium ion export (GO:0071436)1.97770049
141phospholipid dephosphorylation (GO:0046839)1.97655796
142phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)1.97346458
143inner ear receptor cell development (GO:0060119)1.97069510
144actin filament polymerization (GO:0030041)1.96820013
145regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)1.95575338
146regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)1.94513584
147dendrite morphogenesis (GO:0048813)1.93865165
148regulation of Rap GTPase activity (GO:0032317)1.93247546
149regulation of B cell receptor signaling pathway (GO:0050855)1.92105285
150negative regulation of macrophage derived foam cell differentiation (GO:0010745)1.92031817
151vocalization behavior (GO:0071625)1.91397493
152regulation of calcineurin-NFAT signaling cascade (GO:0070884)1.91291602
153neutrophil activation (GO:0042119)1.90587278
154positive regulation of Rap GTPase activity (GO:0032854)1.90568363
155potassium ion import (GO:0010107)1.90475475
156thymic T cell selection (GO:0045061)1.90382881
157lipid phosphorylation (GO:0046834)1.90289398
158striated muscle atrophy (GO:0014891)1.89792036
159tyrosine phosphorylation of STAT protein (GO:0007260)1.89090935
160cerebellar Purkinje cell differentiation (GO:0021702)1.88809789
161embryonic camera-type eye morphogenesis (GO:0048596)1.88027582
162insulin-like growth factor receptor signaling pathway (GO:0048009)1.87531063
163plasma lipoprotein particle assembly (GO:0034377)1.85884052
164phosphatidylinositol phosphorylation (GO:0046854)1.85336429
165protein-lipid complex assembly (GO:0065005)1.84210480
166positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.83054330
167response to immune response of other organism involved in symbiotic interaction (GO:0052564)1.82395787
168response to host immune response (GO:0052572)1.82395787

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM2B_26808549_Chip-Seq_SUP-B15_Human2.60842032
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.55446810
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.50248649
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.29535734
5TCF7_22412390_ChIP-Seq_EML_Mouse2.21954503
6VDR_21846776_ChIP-Seq_THP-1_Human2.21583630
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.17895727
8DROSHA_22980978_ChIP-Seq_HELA_Human2.16147530
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.11424197
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.06901570
11KDM2B_26808549_Chip-Seq_DND41_Human2.06454481
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.06330591
13GBX2_23144817_ChIP-Seq_PC3_Human2.00203724
14MYC_22102868_ChIP-Seq_BL_Human1.95336765
15KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.90083813
16MYB_21317192_ChIP-Seq_ERMYB_Mouse1.88280249
17VDR_24763502_ChIP-Seq_THP-1_Human1.87831734
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84314179
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.82871073
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80001575
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79031760
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75851301
23* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68976438
24LXR_22292898_ChIP-Seq_THP-1_Human1.68589558
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66126905
26MAF_26560356_Chip-Seq_TH1_Human1.65394775
27KDM2B_26808549_Chip-Seq_JURKAT_Human1.65078286
28RUNX_20019798_ChIP-Seq_JUKART_Human1.63244018
29MYB_26560356_Chip-Seq_TH1_Human1.63171126
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60585719
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.60400023
32EZH2_22144423_ChIP-Seq_EOC_Human1.60232182
33UTX_26944678_Chip-Seq_JUKART_Human1.60030310
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59649848
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55592238
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52712943
37TP53_16413492_ChIP-PET_HCT116_Human1.51310587
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51303801
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48544045
40AHR_22903824_ChIP-Seq_MCF-7_Human1.48503334
41KDM2B_26808549_Chip-Seq_K562_Human1.47997645
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47387697
43GATA1_19941827_ChIP-Seq_MEL_Mouse1.46583253
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46256314
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45884160
46* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43945587
47CTNNB1_20460455_ChIP-Seq_HCT116_Human1.42442520
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.41820618
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40956567
50MYB_26560356_Chip-Seq_TH2_Human1.39933435
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.39932358
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38648920
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.36897991
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34674017
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34248696
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.34221478
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.34114192
58MAF_26560356_Chip-Seq_TH2_Human1.33852111
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33786197
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33396789
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.31556596
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.25076799
63FOXA2_19822575_ChIP-Seq_HepG2_Human1.24048340
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23973974
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23623055
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23549844
67AR_21572438_ChIP-Seq_LNCaP_Human1.23236016
68CDX2_20551321_ChIP-Seq_CACO-2_Human1.21096216
69RUNX1_27514584_Chip-Seq_MCF-7_Human1.20300578
70SPI1_23127762_ChIP-Seq_K562_Human1.20148691
71VDR_24787735_ChIP-Seq_THP-1_Human1.20045184
72* SMAD4_21799915_ChIP-Seq_A2780_Human1.19189988
73STAT3_23295773_ChIP-Seq_U87_Human1.19087364
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18963478
75RACK7_27058665_Chip-Seq_MCF-7_Human1.16188125
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15976796
77SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15892552
78* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15661915
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13770482
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12934834
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12632210
82* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10392633
83IRF8_21731497_ChIP-ChIP_J774_Mouse1.10038775
84* PU_27001747_Chip-Seq_BMDM_Mouse1.07902455
85SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07328981
86SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07158218
87MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06785333
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06226939
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05874784
90SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05866337
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05839780
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.05775617
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05584791
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05258533
95CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04940078
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04803311
97* TCF4_23295773_ChIP-Seq_U87_Human1.04417741
98* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04089135
99ZNF263_19887448_ChIP-Seq_K562_Human1.03128624
100GATA3_27048872_Chip-Seq_THYMUS_Human1.01880683
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01497368
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01488825
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01473979
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01091202
105SCL_19346495_ChIP-Seq_HPC-7_Human1.01081597
106RXR_22108803_ChIP-Seq_LS180_Human1.00981993
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00775474
108NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00083743
109EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99870313
110SPI1_23547873_ChIP-Seq_NB4_Human0.98452029
111GATA1_22025678_ChIP-Seq_K562_Human0.98216381
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97489819
113SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97262264
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.97245502
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97222489
116GATA2_19941826_ChIP-Seq_K562_Human0.97219570
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97187307
118ESR2_21235772_ChIP-Seq_MCF-7_Human0.96853043
119TAF15_26573619_Chip-Seq_HEK293_Human0.96752883
120STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96500544
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96493880
122TBX20_22080862_ChIP-Seq_HEART_Mouse0.96257036
123TBX20_22328084_ChIP-Seq_HEART_Mouse0.96257036
124SMAD3_21741376_ChIP-Seq_EPCs_Human0.95675468
125TCF4_18268006_ChIP-ChIP_LS174T_Human0.95480822
126MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95185184
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94993152
128AR_25329375_ChIP-Seq_VCAP_Human0.94532777
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93949426
130P300_19829295_ChIP-Seq_ESCs_Human0.93921211
131NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93865293
132NANOG_18555785_Chip-Seq_ESCs_Mouse0.93846723
133AR_19668381_ChIP-Seq_PC3_Human0.93746677
134SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92932781
135RNF2_18974828_ChIP-Seq_MESCs_Mouse0.91494269
136EZH2_18974828_ChIP-Seq_MESCs_Mouse0.91494269
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90787175
138TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89959836
139IGF1R_20145208_ChIP-Seq_DFB_Human0.89886588
140SMAD3_21741376_ChIP-Seq_HESCs_Human0.89794435
141SMC4_20622854_ChIP-Seq_HELA_Human0.89604051
142SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89552263
143GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89129796
144* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88891731
145JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87554861
146* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87211660
147P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87016342
148NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86798618
149ESR1_21235772_ChIP-Seq_MCF-7_Human0.86797847
150TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86737142
151SMAD4_21741376_ChIP-Seq_HESCs_Human0.86606964
152FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86580543
153EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86447743
154GATA1_19941826_ChIP-Seq_K562_Human0.86351185
155* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86005985
156LXR_22158963_ChIP-Seq_LIVER_Mouse0.85237460
157RNF2_27304074_Chip-Seq_ESCs_Mouse0.85056289
158ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84303632
159BCAT_22108803_ChIP-Seq_LS180_Human0.84289501
160SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.84111801
161E2F1_18555785_Chip-Seq_ESCs_Mouse0.83747189
162POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83591752

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation7.35510040
2MP0003300_gastrointestinal_ulcer3.00027139
3MP0005360_urolithiasis2.95310883
4MP0003045_fibrosis2.89446439
5MP0003763_abnormal_thymus_physiology2.80987609
6MP0005174_abnormal_tail_pigmentation2.46514734
7MP0003724_increased_susceptibility_to2.43420781
8MP0003252_abnormal_bile_duct2.43182984
9MP0001666_abnormal_nutrient_absorption2.42699306
10MP0003705_abnormal_hypodermis_morpholog2.34711942
11MP0003183_abnormal_peptide_metabolism2.28821448
12MP0005451_abnormal_body_composition2.04713710
13MP0003866_abnormal_defecation2.03225993
14MP0000015_abnormal_ear_pigmentation2.01944562
15MP0009780_abnormal_chondrocyte_physiolo1.97599412
16MP0004510_myositis1.97421007
17MP0002166_altered_tumor_susceptibility1.94704950
18MP0003172_abnormal_lysosome_physiology1.89393275
19MP0001790_abnormal_immune_system1.86121686
20MP0005387_immune_system_phenotype1.86121686
21MP0003787_abnormal_imprinting1.85131995
22MP0008260_abnormal_autophagy1.78133524
23MP0003329_amyloid_beta_deposits1.74357450
24MP0001835_abnormal_antigen_presentation1.74184542
25MP0001873_stomach_inflammation1.69484942
26MP0003091_abnormal_cell_migration1.68907326
27MP0003828_pulmonary_edema1.65897200
28MP0004130_abnormal_muscle_cell1.63722234
29MP0002928_abnormal_bile_duct1.62309267
30MP0004859_abnormal_synaptic_plasticity1.49164622
31MP0001800_abnormal_humoral_immune1.46273951
32MP0002396_abnormal_hematopoietic_system1.43171027
33MP0009379_abnormal_foot_pigmentation1.40241542
34MP0005464_abnormal_platelet_physiology1.37111353
35MP0009785_altered_susceptibility_to1.32858372
36MP0005310_abnormal_salivary_gland1.32715648
37MP0002006_tumorigenesis1.32300440
38MP0008961_abnormal_basal_metabolism1.31528871
39MP0002148_abnormal_hypersensitivity_rea1.30977883
40MP0004947_skin_inflammation1.29839987
41MP0010352_gastrointestinal_tract_polyps1.28205470
42MP0000371_diluted_coat_color1.26507603
43MP0002405_respiratory_system_inflammati1.25683463
44MP0003868_abnormal_feces_composition1.25361925
45MP0010155_abnormal_intestine_physiology1.24874943
46MP0002452_abnormal_antigen_presenting1.24087563
47MP0002419_abnormal_innate_immunity1.22443557
48MP0009115_abnormal_fat_cell1.22087812
49MP0006082_CNS_inflammation1.21701259
50MP0002822_catalepsy1.20226688
51MP0001851_eye_inflammation1.19971322
52MP0002254_reproductive_system_inflammat1.18480594
53MP0005666_abnormal_adipose_tissue1.16911454
54MP0005448_abnormal_energy_balance1.16844015
55MP0002723_abnormal_immune_serum1.13256425
56MP0004484_altered_response_of1.12799250
57MP0001849_ear_inflammation1.12709740
58MP0005076_abnormal_cell_differentiation1.11527636
59MP0000462_abnormal_digestive_system1.11361862
60MP0003566_abnormal_cell_adhesion1.10352701
61MP0000703_abnormal_thymus_morphology1.10088678
62MP0005257_abnormal_intraocular_pressure1.09120519
63MP0003436_decreased_susceptibility_to1.07934631
64MP0005671_abnormal_response_to1.07619346
65MP0002722_abnormal_immune_system1.07545465
66MP0003303_peritoneal_inflammation1.07337181
67MP0005365_abnormal_bile_salt1.06534228
68MP0001819_abnormal_immune_cell1.05813187
69MP0002420_abnormal_adaptive_immunity1.04815599
70MP0005000_abnormal_immune_tolerance1.03671977
71MP0002168_other_aberrant_phenotype1.03394018
72MP0003191_abnormal_cellular_cholesterol1.02358835
73MP0001663_abnormal_digestive_system1.01915568
74MP0005058_abnormal_lysosome_morphology1.01829526
75MP0000689_abnormal_spleen_morphology1.01780948
76MP0000465_gastrointestinal_hemorrhage0.99700686
77MP0010329_abnormal_lipoprotein_level0.99625405
78MP0005166_decreased_susceptibility_to0.99345818
79MP0004883_abnormal_blood_vessel0.98524400
80MP0002429_abnormal_blood_cell0.98125565
81MP0004264_abnormal_extraembryonic_tissu0.97634761
82MP0002971_abnormal_brown_adipose0.95918120
83MP0000249_abnormal_blood_vessel0.94690887
84MP0010307_abnormal_tumor_latency0.93415117
85MP0002909_abnormal_adrenal_gland0.93135076
86MP0002138_abnormal_hepatobiliary_system0.92644959
87MP0001958_emphysema0.91333673
88MP0002998_abnormal_bone_remodeling0.91171598
89MP0003453_abnormal_keratinocyte_physiol0.91102467
90MP0001177_atelectasis0.90933453
91MP0008469_abnormal_protein_level0.90926032
92MP0000685_abnormal_immune_system0.89662978
93MP0009333_abnormal_splenocyte_physiolog0.88330916
94MP0002089_abnormal_postnatal_growth/wei0.87190116
95MP0002249_abnormal_larynx_morphology0.86273824
96MP0009840_abnormal_foam_cell0.86215177
97MP0005670_abnormal_white_adipose0.85013473
98MP0005409_darkened_coat_color0.84998207
99MP0004270_analgesia0.83986889
100MP0009278_abnormal_bone_marrow0.83772007
101MP0000604_amyloidosis0.83691747
102MP0002136_abnormal_kidney_physiology0.83406562
103MP0002876_abnormal_thyroid_physiology0.83224785
104MP0002735_abnormal_chemical_nociception0.83109665
105MP0002693_abnormal_pancreas_physiology0.82763175
106MP0004808_abnormal_hematopoietic_stem0.82687588
107MP0010234_abnormal_vibrissa_follicle0.82060439
108MP0000858_altered_metastatic_potential0.81838326
109MP0003690_abnormal_glial_cell0.81808997
110MP0005025_abnormal_response_to0.81698434
111MP0005085_abnormal_gallbladder_physiolo0.81642490
112MP0002837_dystrophic_cardiac_calcinosis0.81041315
113MP0004381_abnormal_hair_follicle0.78450144
114MP0001486_abnormal_startle_reflex0.78163659
115MP0010678_abnormal_skin_adnexa0.77391065
116MP0005375_adipose_tissue_phenotype0.76974525
117MP0000427_abnormal_hair_cycle0.76933881
118MP0005334_abnormal_fat_pad0.76856282
119MP0000383_abnormal_hair_follicle0.75720830
120MP0009764_decreased_sensitivity_to0.75053912
121MP0005645_abnormal_hypothalamus_physiol0.74988822
122MP0002095_abnormal_skin_pigmentation0.74621449
123MP0000716_abnormal_immune_system0.71905487
124MP0004185_abnormal_adipocyte_glucose0.71782066
125MP0005621_abnormal_cell_physiology0.71091548
126MP0005023_abnormal_wound_healing0.70448163
127MP0001845_abnormal_inflammatory_respons0.69004455
128MP0001533_abnormal_skeleton_physiology0.68694016
129MP0002078_abnormal_glucose_homeostasis0.68453161
130MP0002277_abnormal_respiratory_mucosa0.68363185
131MP0003635_abnormal_synaptic_transmissio0.68120393
132MP0002009_preneoplasia0.68109872
133MP0002398_abnormal_bone_marrow0.67362263
134MP0001765_abnormal_ion_homeostasis0.66869068
135MP0005381_digestive/alimentary_phenotyp0.66852924
136MP0002877_abnormal_melanocyte_morpholog0.66831936
137MP0002572_abnormal_emotion/affect_behav0.66748898
138MP0002139_abnormal_hepatobiliary_system0.66195706
139MP0002933_joint_inflammation0.65907207
140MP0000767_abnormal_smooth_muscle0.65505397
141MP0000609_abnormal_liver_physiology0.65316433

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.85847760
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.12223899
3Short 4th metacarpal (HP:0010044)3.12223899
4Abnormal delayed hypersensitivity skin test (HP:0002963)3.05434581
5Spontaneous hematomas (HP:0007420)2.98179805
6Abnormality of macrophages (HP:0004311)2.92166001
7Conjugated hyperbilirubinemia (HP:0002908)2.87425696
8Malnutrition (HP:0004395)2.73273945
9Myositis (HP:0100614)2.67018774
10Gastrointestinal infarctions (HP:0005244)2.66833573
11Chronic diarrhea (HP:0002028)2.65192228
12Subacute progressive viral hepatitis (HP:0006572)2.58494154
13Infantile muscular hypotonia (HP:0008947)2.58035913
14Orchitis (HP:0100796)2.57966936
15Recurrent fungal infections (HP:0002841)2.54767538
16Viral hepatitis (HP:0006562)2.54308077
17Autoimmune thrombocytopenia (HP:0001973)2.52205023
18Macroorchidism (HP:0000053)2.51667851
19Periodontitis (HP:0000704)2.50762511
20Cellulitis (HP:0100658)2.50632542
21Recurrent viral infections (HP:0004429)2.48909331
22Myocardial infarction (HP:0001658)2.47314189
23Recurrent gram-negative bacterial infections (HP:0005420)2.46424933
24Increased IgE level (HP:0003212)2.43460876
25Gingivitis (HP:0000230)2.34712728
26Radial bowing (HP:0002986)2.32626271
27Retrobulbar optic neuritis (HP:0100654)2.31568024
28Optic neuritis (HP:0100653)2.31568024
29Acanthocytosis (HP:0001927)2.28735261
30Facial shape deformation (HP:0011334)2.23951908
31Potter facies (HP:0002009)2.23951908
32Absent frontal sinuses (HP:0002688)2.22939177
33Thin bony cortex (HP:0002753)2.21397972
34Broad face (HP:0000283)2.21170865
35Febrile seizures (HP:0002373)2.20400101
36Chronic mucocutaneous candidiasis (HP:0002728)2.18233493
37Recurrent cutaneous fungal infections (HP:0011370)2.18233493
38Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.18123232
39Thick nail (HP:0001805)2.17838956
40Lower limb amyotrophy (HP:0007210)2.17714051
41Meningitis (HP:0001287)2.15934491
42Inflammation of the large intestine (HP:0002037)2.13480757
43Obstructive lung disease (HP:0006536)2.12115144
44Chronic obstructive pulmonary disease (HP:0006510)2.12115144
45Mediastinal lymphadenopathy (HP:0100721)2.10979110
46Distal lower limb amyotrophy (HP:0008944)2.10300398
47Narrow palate (HP:0000189)2.09980033
48T lymphocytopenia (HP:0005403)2.09830708
49Colitis (HP:0002583)2.08046064
50Abnormality of the 4th metacarpal (HP:0010012)2.06797001
51Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.05679681
52Progressive cerebellar ataxia (HP:0002073)2.04994340
53Abnormality of T cell number (HP:0011839)2.03050311
54Gingival bleeding (HP:0000225)2.01450945
55Aortic aneurysm (HP:0004942)2.00261768
56Eosinophilia (HP:0001880)2.00072041
57Visual hallucinations (HP:0002367)1.99626669
58Osteomyelitis (HP:0002754)1.98021921
59Disproportionate tall stature (HP:0001519)1.97510563
60Urinary bladder sphincter dysfunction (HP:0002839)1.97500934
61Eczematoid dermatitis (HP:0000976)1.96891293
62Progressive sensorineural hearing impairment (HP:0000408)1.96793388
63Broad metatarsal (HP:0001783)1.96446774
64Hepatitis (HP:0012115)1.95774155
65Persistence of primary teeth (HP:0006335)1.95241824
66Abnormality of the nasal septum (HP:0000419)1.93587259
67Hemoptysis (HP:0002105)1.92894468
68Gastrointestinal inflammation (HP:0004386)1.92715739
69Cerebral aneurysm (HP:0004944)1.91559911
70Progressive hearing impairment (HP:0001730)1.91033629
71Arterial tortuosity (HP:0005116)1.90903863
72Chest pain (HP:0100749)1.89181086
73Encephalitis (HP:0002383)1.88559483
74Recurrent bacterial skin infections (HP:0005406)1.87651429
75Esophageal varix (HP:0002040)1.87477202
76Pustule (HP:0200039)1.87188952
77Elevated erythrocyte sedimentation rate (HP:0003565)1.87045522
78Open mouth (HP:0000194)1.86778883
79Supernumerary nipples (HP:0002558)1.86062686
80Thyroiditis (HP:0100646)1.84847747
81Submucous cleft hard palate (HP:0000176)1.84155433
82Ileus (HP:0002595)1.83576121
83Brushfield spots (HP:0001088)1.83229885
84Hydroxyprolinuria (HP:0003080)1.82123029
85Abnormality of proline metabolism (HP:0010907)1.82123029
86Dysmetric saccades (HP:0000641)1.81170692
87Hyperacusis (HP:0010780)1.81099587
88Granulocytopenia (HP:0001913)1.81011819
89Insulin-resistant diabetes mellitus (HP:0000831)1.80131051
90Difficulty running (HP:0009046)1.78953964
91Bowed forearm bones (HP:0003956)1.78348690
92Bowing of the arm (HP:0006488)1.78348690
93Generalized hypopigmentation of hair (HP:0011358)1.78192109
94Agammaglobulinemia (HP:0004432)1.78177740
95Syringomyelia (HP:0003396)1.77742390
96Spinal cord lesions (HP:0100561)1.77742390
97Mitral stenosis (HP:0001718)1.77556117
98Abnormality of the distal phalanx of the thumb (HP:0009617)1.77083019
99Abnormal platelet volume (HP:0011876)1.76642904
100Frequent falls (HP:0002359)1.76397232
101Ocular albinism (HP:0001107)1.75548884
102Hemiplegia (HP:0002301)1.75491504
103Vasculitis (HP:0002633)1.74342656
104Albinism (HP:0001022)1.74079907
105Abnormality of liposaccharide metabolism (HP:0010968)1.73621316
106Abnormality of glycosphingolipid metabolism (HP:0004343)1.73621316
107Abnormality of glycolipid metabolism (HP:0010969)1.73621316
108Pulmonary infiltrates (HP:0002113)1.73588582
109Panhypogammaglobulinemia (HP:0003139)1.73320683
110Interstitial pulmonary disease (HP:0006530)1.72972313
111Stomatitis (HP:0010280)1.72689313
112Abnormality of glutamine family amino acid metabolism (HP:0010902)1.72460181
113Asymmetric septal hypertrophy (HP:0001670)1.72020718
114Conjunctival telangiectasia (HP:0000524)1.71236997
115Fatigue (HP:0012378)1.71121851
116Increased connective tissue (HP:0009025)1.70621796
117Abdominal distention (HP:0003270)1.70108453
118Aneurysm (HP:0002617)1.69646025
119Dysostosis multiplex (HP:0000943)1.69495856
120Gaze-evoked nystagmus (HP:0000640)1.68489461
121Gastrointestinal stroma tumor (HP:0100723)1.68464860
122Peritonitis (HP:0002586)1.66878451
123Tibial bowing (HP:0002982)1.66858165
124Obstructive sleep apnea (HP:0002870)1.66782246
125Spondylolisthesis (HP:0003302)1.66754012
126Vascular tortuosity (HP:0004948)1.66399186
127Long toe (HP:0010511)1.65808327
128Abnormality of the vasculature of the conjunctiva (HP:0008054)1.65644901
129Coarse hair (HP:0002208)1.65426100
130Generalized hypopigmentation (HP:0007513)1.65403913
131Hemorrhage of the eye (HP:0011885)1.64888933
132Abnormal hair whorl (HP:0010721)1.64650903
133Hematochezia (HP:0002573)1.64626361
134Epistaxis (HP:0000421)1.64405293
135Flat acetabular roof (HP:0003180)1.64148708
136Poikilocytosis (HP:0004447)1.63422237
137Pulmonary embolism (HP:0002204)1.62975652
138Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.62384856
139Epidermoid cyst (HP:0200040)1.61420040
140Elfin facies (HP:0004428)1.60775062
141Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.60267904
142Drooling (HP:0002307)1.60090939
143Excessive salivation (HP:0003781)1.60090939
144Symptomatic seizures (HP:0011145)1.59667400
145Recurrent abscess formation (HP:0002722)1.59464007
146Truncal obesity (HP:0001956)1.59439407
147Recurrent skin infections (HP:0001581)1.58584791
148Increased mean platelet volume (HP:0011877)1.57636384
149Heterotopia (HP:0002282)1.56864873
150Chronic hepatic failure (HP:0100626)1.56418147
151Hypoplastic ischia (HP:0003175)1.56053702
152Emphysema (HP:0002097)1.54914360
153Hip dysplasia (HP:0001385)1.54121923
154Abnormal foot bone ossification (HP:0010675)1.53799216
155Prostate neoplasm (HP:0100787)1.53651428
156Onion bulb formation (HP:0003383)1.53471970
157Focal seizures (HP:0007359)1.53072908
158Slow saccadic eye movements (HP:0000514)1.52888997
159Thick eyebrow (HP:0000574)1.51944338
160Truncal ataxia (HP:0002078)1.50819775
161Mask-like facies (HP:0000298)1.50217802
162Widely spaced teeth (HP:0000687)1.49726899
163Prolonged bleeding time (HP:0003010)1.49197410
164Ureteral obstruction (HP:0006000)1.49110270
165Abnormality of incisor morphology (HP:0011063)1.47327206

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.10454639
2INSRR2.98212296
3FRK2.85784170
4SIK22.50526831
5IRAK32.46016613
6MAP3K142.12451827
7JAK12.09689926
8MAP3K92.06836859
9MAP2K32.04186303
10EPHB12.00046265
11CAMK1G1.99547913
12KSR21.99250953
13CAMK1D1.96720872
14TYRO31.78231553
15CDK121.75286647
16SMG11.67087290
17RIPK41.64599451
18BLK1.64161869
19SIK11.57388125
20TAOK21.54134764
21MAP3K131.53809801
22TYK21.51547625
23TAOK11.45292287
24MAP3K31.44993139
25SGK31.44233232
26MAP4K11.44079272
27NUAK11.41683599
28EPHA31.39726850
29JAK31.38174528
30MAP3K101.37089981
31IRAK41.34350902
32MAP3K11.31426839
33RIPK11.30910045
34PRKCH1.29844941
35EEF2K1.29332052
36TGFBR21.28593790
37SGK21.26897898
38ZAP701.26761879
39PTK61.26148425
40FGFR41.26032600
41NME11.25627107
42MAP3K21.24653564
43FGFR31.21652193
44TXK1.18069669
45MOS1.18033438
46TTN1.16323792
47WNK11.13717258
48MARK21.13066186
49PKN11.12859276
50NTRK31.12106600
51HIPK21.10973068
52IKBKE1.10674494
53MAP3K41.09627125
54BRD41.09108276
55MST1R1.09062750
56PRKD21.08862568
57NLK1.06748989
58MAP3K71.05863516
59DMPK1.03888541
60BTK1.03721724
61HCK1.00920238
62FES1.00730290
63LMTK20.94224316
64PDGFRB0.93803381
65PRKAA20.93060356
66LATS10.92628566
67ITK0.89008382
68PAK60.88997815
69TRPM70.83079566
70SGK10.81756603
71KSR10.81734834
72AKT30.81289230
73FGFR20.81088769
74IRAK10.79661996
75MARK10.79647522
76CDC42BPA0.79194497
77GRK60.77808294
78PKN20.75478852
79EPHA40.75228303
80MTOR0.75085202
81JAK20.73365611
82CSK0.73238272
83SIK30.73017639
84SGK2230.72851782
85SGK4940.72851782
86MELK0.72648438
87PRKCQ0.70349131
88CHUK0.68855678
89TRIB30.67383444
90MAPK110.66278679
91PIK3CG0.65978794
92LCK0.65931383
93RAF10.65921282
94MAPK120.65271062
95CDK60.64809618
96RET0.64239768
97YES10.63131835
98PIK3CA0.62626943
99PAK30.61162386
100LYN0.60891911
101PTK20.59775758
102PRKAA10.58617784
103SYK0.58605024
104RPS6KC10.58292391
105RPS6KL10.58292391
106MAP3K60.58231067
107ERN10.58189731
108RPS6KA20.57603585
109PRKD30.57484868
110MARK30.57384983
111KIT0.57151896
112PDPK10.56560131
113FYN0.56507932
114DYRK1B0.56382207
115ACVR1B0.56026571
116IRAK20.55864606
117CDK90.55357338
118MST40.55084330
119STK110.54891145
120IKBKB0.54466183
121ZAK0.53293310
122TNK20.52174365
123PDK10.51791832
124CLK10.51153948
125TBK10.50388439
126PIM10.50379842
127ICK0.50240201
128CAMKK10.50228652
129PRKD10.50011720
130TNIK0.49355630
131STK380.48527407
132PRKCE0.48285181
133STK240.48069262
134ALK0.47567851
135RPS6KA60.47531519
136CSF1R0.46685653
137PRPF4B0.46529582

Predicted pathways (KEGG)

RankGene SetZ-score
1Carbohydrate digestion and absorption_Homo sapiens_hsa049731.91617096
2Type II diabetes mellitus_Homo sapiens_hsa049301.90676517
3Lysine degradation_Homo sapiens_hsa003101.54553880
4Other glycan degradation_Homo sapiens_hsa005111.52811267
5Caffeine metabolism_Homo sapiens_hsa002321.50607236
6ABC transporters_Homo sapiens_hsa020101.49586108
7Fat digestion and absorption_Homo sapiens_hsa049751.49150491
8Non-small cell lung cancer_Homo sapiens_hsa052231.46227467
9Phosphatidylinositol signaling system_Homo sapiens_hsa040701.45745299
10Maturity onset diabetes of the young_Homo sapiens_hsa049501.44710577
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40679463
12Staphylococcus aureus infection_Homo sapiens_hsa051501.38318211
13Renin-angiotensin system_Homo sapiens_hsa046141.37757139
14Mineral absorption_Homo sapiens_hsa049781.32314263
15Renal cell carcinoma_Homo sapiens_hsa052111.32021539
16VEGF signaling pathway_Homo sapiens_hsa043701.29090496
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24514029
18B cell receptor signaling pathway_Homo sapiens_hsa046621.21146509
19Osteoclast differentiation_Homo sapiens_hsa043801.21013854
20Endometrial cancer_Homo sapiens_hsa052131.19654830
21Insulin secretion_Homo sapiens_hsa049111.19102122
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.15193364
23Primary immunodeficiency_Homo sapiens_hsa053401.12961961
24Bile secretion_Homo sapiens_hsa049761.12812641
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10654378
26Starch and sucrose metabolism_Homo sapiens_hsa005001.09933202
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08775325
28Hepatitis B_Homo sapiens_hsa051611.05955300
29Insulin resistance_Homo sapiens_hsa049311.03135828
30Salivary secretion_Homo sapiens_hsa049701.02418772
31Dorso-ventral axis formation_Homo sapiens_hsa043201.02380424
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02084236
33Notch signaling pathway_Homo sapiens_hsa043301.01205901
34Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99852199
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99132894
36Graft-versus-host disease_Homo sapiens_hsa053320.98784548
37Viral myocarditis_Homo sapiens_hsa054160.98226247
38Renin secretion_Homo sapiens_hsa049240.97894498
39Allograft rejection_Homo sapiens_hsa053300.97762792
40Intestinal immune network for IgA production_Homo sapiens_hsa046720.96922487
41Morphine addiction_Homo sapiens_hsa050320.94939628
42FoxO signaling pathway_Homo sapiens_hsa040680.94764482
43Protein digestion and absorption_Homo sapiens_hsa049740.93879663
44Autoimmune thyroid disease_Homo sapiens_hsa053200.93670704
45T cell receptor signaling pathway_Homo sapiens_hsa046600.93613779
46Inositol phosphate metabolism_Homo sapiens_hsa005620.93323719
47Chemokine signaling pathway_Homo sapiens_hsa040620.92700801
48Prion diseases_Homo sapiens_hsa050200.92673141
49Vitamin digestion and absorption_Homo sapiens_hsa049770.92635272
50Gastric acid secretion_Homo sapiens_hsa049710.90738186
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90162796
52Taste transduction_Homo sapiens_hsa047420.89740890
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89009788
54Olfactory transduction_Homo sapiens_hsa047400.87686636
55Cholinergic synapse_Homo sapiens_hsa047250.86671071
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.86561804
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83724091
58Toxoplasmosis_Homo sapiens_hsa051450.83602214
59Circadian entrainment_Homo sapiens_hsa047130.83515465
60Adherens junction_Homo sapiens_hsa045200.83508516
61Glutamatergic synapse_Homo sapiens_hsa047240.83320936
62Chronic myeloid leukemia_Homo sapiens_hsa052200.81905795
63TNF signaling pathway_Homo sapiens_hsa046680.80995094
64Choline metabolism in cancer_Homo sapiens_hsa052310.79554467
65Dilated cardiomyopathy_Homo sapiens_hsa054140.79453123
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79331234
67Pancreatic secretion_Homo sapiens_hsa049720.78746049
68Measles_Homo sapiens_hsa051620.78677148
69Hematopoietic cell lineage_Homo sapiens_hsa046400.78581479
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78071272
71Prostate cancer_Homo sapiens_hsa052150.77016545
72Apoptosis_Homo sapiens_hsa042100.76450500
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75352272
74Sphingolipid metabolism_Homo sapiens_hsa006000.75088209
75Leishmaniasis_Homo sapiens_hsa051400.74345298
76Malaria_Homo sapiens_hsa051440.74048051
77HIF-1 signaling pathway_Homo sapiens_hsa040660.73736003
78Insulin signaling pathway_Homo sapiens_hsa049100.73711903
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73700328
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73171139
81ErbB signaling pathway_Homo sapiens_hsa040120.72772087
82Colorectal cancer_Homo sapiens_hsa052100.72643681
83GnRH signaling pathway_Homo sapiens_hsa049120.72309435
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71928370
85cAMP signaling pathway_Homo sapiens_hsa040240.71710572
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.70038344
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69620641
88Thyroid hormone synthesis_Homo sapiens_hsa049180.69300259
89Platelet activation_Homo sapiens_hsa046110.68995138
90Nicotine addiction_Homo sapiens_hsa050330.68755815
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68177196
92Prolactin signaling pathway_Homo sapiens_hsa049170.67810962
93Tuberculosis_Homo sapiens_hsa051520.66369631
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65957072
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.65939489
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65355258
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.64951547
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.63629984
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63490302
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.63328167
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.62997023
102Hepatitis C_Homo sapiens_hsa051600.62152768
103Focal adhesion_Homo sapiens_hsa045100.61731492
104Herpes simplex infection_Homo sapiens_hsa051680.61626478
105mTOR signaling pathway_Homo sapiens_hsa041500.61348981
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61294370
107MAPK signaling pathway_Homo sapiens_hsa040100.61239199
108Pancreatic cancer_Homo sapiens_hsa052120.61220088
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61191716
110Calcium signaling pathway_Homo sapiens_hsa040200.60559292
111GABAergic synapse_Homo sapiens_hsa047270.60456841
112Endocytosis_Homo sapiens_hsa041440.60295491
113Estrogen signaling pathway_Homo sapiens_hsa049150.60203401
114Glioma_Homo sapiens_hsa052140.59733875
115Influenza A_Homo sapiens_hsa051640.59557995
116Type I diabetes mellitus_Homo sapiens_hsa049400.59533875
117Cocaine addiction_Homo sapiens_hsa050300.59373760
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58984979
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58755456
120MicroRNAs in cancer_Homo sapiens_hsa052060.58589246
121Long-term potentiation_Homo sapiens_hsa047200.58206412
122ECM-receptor interaction_Homo sapiens_hsa045120.58090886
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57925068
124Glycerolipid metabolism_Homo sapiens_hsa005610.57914331
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.57900527
126Antigen processing and presentation_Homo sapiens_hsa046120.56351557
127Fructose and mannose metabolism_Homo sapiens_hsa000510.56026987
128Proteoglycans in cancer_Homo sapiens_hsa052050.56020905
129Oxytocin signaling pathway_Homo sapiens_hsa049210.55662613
130Thyroid cancer_Homo sapiens_hsa052160.55428592
131Acute myeloid leukemia_Homo sapiens_hsa052210.55272070
132Amoebiasis_Homo sapiens_hsa051460.54902988
133Bladder cancer_Homo sapiens_hsa052190.54829587
134Pertussis_Homo sapiens_hsa051330.54745993
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54597256
136Axon guidance_Homo sapiens_hsa043600.54107199
137PPAR signaling pathway_Homo sapiens_hsa033200.54013573
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53994166
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52542363
140Galactose metabolism_Homo sapiens_hsa000520.51737239
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.51080894

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