Small molecules which reverse Down syndrome
Canned Analysis
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General Information
AccessionDCA00009399
TitleSmall molecules which reverse Down syndrome
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the Down syndrome gene expression signature in the CNS - Brain - Cerebellum (MMHCC) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1bc81e467bea600fb8310
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:105
Cell TypeCNS - Brain - Cerebellum (MMHCC)
DO IDDOID:14250
Disease NameDown syndrome
Organismmouse
UMLS CUIC0013080
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM27472, GSM27473, GSM27474, GSM27475, GSM27476, GSM27477
Perturbed SamplesGSM27478, GSM27479, GSM27480, GSM27481, GSM27482, GSM27483
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1611
Gene Expression Omnibus
Segmental trisomy Ts1Cje model for Down syndrome
7
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