Small molecules which mimic Down syndrome
Canned Analysis
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General Information
AccessionDCA00009418
TitleSmall molecules which mimic Down syndrome
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the Down syndrome gene expression signature in the fibroblast cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1cc49e467bea600fb8ad4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdz:1060
Cell Typefibroblast
DO IDDOID:14250
Disease NameDown syndrome
Organismhuman
UMLS CUIC0013080
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1053952, GSM1053953, GSM1053954, GSM1053955, GSM1053956, GSM1053957, GSM1053961, GSM1053962, GSM1053963, GSM1053976, GSM1053977, GSM1053978, GSM1053979, GSM1053980, GSM1053981
Perturbed SamplesGSM1053958, GSM1053959, GSM1053960, GSM1053982, GSM1053983, GSM1053984
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE42956
Gene Expression Omnibus
Integration-Free Induced Pluripotent Stem Cells Model Genetic and Neural Developmental Features of Down Syndrome Etiology
14
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