Small molecules which mimic Down syndrome
Canned Analysis
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General Information
AccessionDCA00009420
TitleSmall molecules which mimic Down syndrome
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the Down syndrome gene expression signature in the induced pluripotent stem cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1ce15e467bea600fb8bb8
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdz:1061
Cell Typeinduced pluripotent stem cells
DO IDDOID:14250
Disease NameDown syndrome
Organismhuman
UMLS CUIC0013080
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1053943, GSM1053944, GSM1053945, GSM1053946, GSM1053947, GSM1053948, GSM1053967, GSM1053968, GSM1053969, GSM1053985, GSM1053986, GSM1053987, GSM1053988, GSM1053989, GSM1053990
Perturbed SamplesGSM1053964, GSM1053965, GSM1053966, GSM1053970, GSM1053971, GSM1053972, GSM1053991, GSM1053992, GSM1053993, GSM1053994, GSM1053995, GSM1053996
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE42956
Gene Expression Omnibus
Integration-Free Induced Pluripotent Stem Cells Model Genetic and Neural Developmental Features of Down Syndrome Etiology
14
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