Small molecules which reverse Down syndrome
Canned Analysis
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General Information
AccessionDCA00009423
TitleSmall molecules which reverse Down syndrome
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the Down syndrome gene expression signature in the induced pluripotent stem cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1cc3be467bea600fb8ace
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdz:1062
Cell Typeinduced pluripotent stem cells
DO IDDOID:14250
Disease NameDown syndrome
Organismhuman
UMLS CUIC0013080
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM870541, GSM870542, GSM870543
Perturbed SamplesGSM870544, GSM870545, GSM870546
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE35561
Gene Expression Omnibus
CD43+/41+/235+ iPSC-derived progenitor cells with germ-line trisomy 21
7
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