Small molecules which mimic Down syndrome
Canned Analysis
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General Information
AccessionDCA00009424
TitleSmall molecules which mimic Down syndrome
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the Down syndrome gene expression signature in the bone marrow cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1cc41e467bea600fb8ad0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdz:1063
Cell Typebone marrow
DO IDDOID:14250
Disease NameDown syndrome
Organismhuman
UMLS CUIC0013080
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM523117, GSM523134, GSM523135, GSM523136, GSM523137, GSM523138, GSM523139, GSM523140, GSM523141, GSM523143, GSM523144, GSM523145, GSM523146, GSM523147, GSM523148, GSM523150, GSM523151, GSM523152, GSM523153, GSM523154, GSM523157, GSM523158, GSM523160, GS
Perturbed SamplesGSM523115, GSM523116, GSM523118, GSM523119, GSM523120, GSM523121, GSM523122, GSM523123, GSM523124, GSM523125, GSM523126, GSM523127, GSM523128, GSM523129, GSM523130, GSM523131, GSM523132, GSM523133, GSM523142, GSM523149, GSM523155, GSM523156, GSM523159
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE20910
Gene Expression Omnibus
Expression data from Down syndrome and non-Down syndrome pediatric acute lymphoblastic leukemia cases
7
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