Small molecules which reverse systemic lupus erythematosus
Canned Analysis
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General Information
AccessionDCA00009439
TitleSmall molecules which reverse systemic lupus erythematosus
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the systemic lupus erythematosus gene expression signature in the CD4+ T cells - European-American SLE patients cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1ca01e467bea600fb89b6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:1073
Cell TypeCD4+ T cells - European-American SLE patients
DO IDDOID:9074
Disease Namesystemic lupus erythematosus
Organismhuman
UMLS CUIC0024141
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1336960, GSM1336961, GSM1336962, GSM1336963, GSM1336964
Perturbed SamplesGSM1336934, GSM1336935, GSM1336936, GSM1336937, GSM1336938, GSM1336939, GSM1336940, GSM1336941, GSM1336942, GSM1336943, GSM1336944, GSM1336945, GSM1336946, GSM1336947, GSM1336948, GSM1336949, GSM1336950, GSM1336951, GSM1336952, GSM1336953, GSM1336954
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE55447
Gene Expression Omnibus
Divergent genome wide transcriptional profiles from immune cell subsets isolated from SLE patients with different ancestral backgrounds
28
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