Small molecules which reverse sickle cell anemia
Canned Analysis
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General Information
AccessionDCA00009453
TitleSmall molecules which reverse sickle cell anemia
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the sickle cell anemia gene expression signature in the Endothelial cell cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1bca6e467bea600fb8324
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:109
Cell TypeEndothelial cell
DO IDDOID:10923
Disease Namesickle cell anemia
Organismhuman
UMLS CUIC0002895
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM249425, GSM249426, GSM249427, GSM249428, GSM249429, GSM249430, GSM249431, GSM249432, GSM249433, GSM249434, GSM249435, GSM249436, GSM249437, GSM249438, GSM249439, GSM249440, GSM249441, GSM249442, GSM249443, GSM249444, GSM249445, GSM249446, GSM249447, GS
Perturbed SamplesGSM249452, GSM249453, GSM249454, GSM249455, GSM249456, GSM249457, GSM249458, GSM249459, GSM249460, GSM249461, GSM249462, GSM249463, GSM249464, GSM249465, GSM249466, GSM249467, GSM249468, GSM249469, GSM249470, GSM249471
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE9877
Gene Expression Omnibus
Genetic Endothelial Systems Biology of Sickle Stroke Risk
7
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