Small molecules which mimic Down syndrome
Canned Analysis
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General Information
AccessionDCA00009860
TitleSmall molecules which mimic Down syndrome
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the Down syndrome gene expression signature in the Fetus cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1cdd3e467bea600fb8b98
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:310
Cell TypeFetus
DO IDDOID:14250
Disease NameDown syndrome
Organismhuman
UMLS CUIC0013080
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM271303, GSM271312, GSM271479, GSM271480, GSM271481, GSM271482
Perturbed SamplesGSM271287, GSM271291, GSM271296, GSM271299
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE10758
Gene Expression Omnibus
Gene expression variation increase in trisomy 21 tissues
7
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