Small molecules which reverse chronic myeloid leukemia
Canned Analysis
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General Information
AccessionDCA00010025
TitleSmall molecules which reverse chronic myeloid leukemia
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the chronic myeloid leukemia gene expression signature in the Haematopoietic stem cell cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1cb85e467bea600fb8a76
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:403
Cell TypeHaematopoietic stem cell
DO IDDOID:8552
Disease Namechronic myeloid leukemia
Organismhuman
UMLS CUIC0023473
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM300128, GSM300129, GSM300130, GSM300131, GSM300132, GSM300133, GSM300134, GSM300135, GSM300136, GSM300137, GSM300138, GSM300139, GSM300140, GSM300141, GSM300142, GSM300144, GSM300146, GSM300147, GSM300148, GSM300149
Perturbed SamplesGSM300093, GSM300100, GSM300101, GSM300102, GSM300103, GSM300104, GSM300105, GSM300106, GSM300107, GSM300108, GSM300109, GSM300111, GSM300112, GSM300114, GSM300115, GSM300116, GSM300117, GSM300118, GSM300119, GSM300120, GSM300121, GSM300122, GSM300123, GS
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE11889
Gene Expression Omnibus
The hematopoietic stem cell in chronic phase CML is characterized by a transcriptional profile resembling normal myeloid progenitor cells and reflecti...
7
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