Small molecules which reverse chronic myeloid leukemia
Canned Analysis
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General Information
AccessionDCA00010131
TitleSmall molecules which reverse chronic myeloid leukemia
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the chronic myeloid leukemia gene expression signature in the CD34+ hematopoietic stem and progenitor cells from the bone marrow of untreated patients cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1cc9de467bea600fb8afe
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatornbongio
CREEDS IDdz:456
Cell TypeCD34+ hematopoietic stem and progenitor cells from the bone marrow of untreated patients
DO IDDOID:8552
Disease Namechronic myeloid leukemia
Organismhuman
UMLS CUIC0023473
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM129002, GSM129050, GSM129051, GSM129054, GSM129055, GSM129056, GSM129057, GSM129058
Perturbed SamplesGSM129059, GSM129060, GSM129061, GSM129062, GSM129063, GSM129064, GSM129065, GSM129066, GSM129067
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE5550
Gene Expression Omnibus
Chronic phase chronic myelogenous leukemia: CD34+ hematopoietic stem and progenitor cells
7
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