Small molecules which reverse macular degeneration
Canned Analysis
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General Information
AccessionDCA00010139
TitleSmall molecules which reverse macular degeneration
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the macular degeneration gene expression signature in the Fibroblast cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1ce89e467bea600fb8bf2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:46
Cell TypeFibroblast
DO IDDOID:4448
Disease Namemacular degeneration
Organismhuman
UMLS CUIC0024437
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM29059, GSM29060, GSM29061, GSM29062, GSM29063, GSM29064, GSM29065, GSM29066, GSM29067, GSM29068, GSM29069, GSM29070, GSM29071, GSM29072, GSM29074, GSM29075, GSM29076, GSM29078
Perturbed SamplesGSM29079, GSM29081, GSM29082, GSM29084, GSM29085, GSM29087, GSM29088, GSM29090, GSM29091, GSM29092, GSM29093, GSM29095, GSM29096, GSM29097, GSM29099, GSM29100, GSM29102, GSM29103
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1719
Gene Expression Omnibus
Macular degeneration and dermal fibroblast response to sublethal oxidative stress
7
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