Small molecules which reverse Niemann-Pick disease
Canned Analysis
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General Information
AccessionDCA00010177
TitleSmall molecules which reverse Niemann-Pick disease
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the Niemann-Pick disease gene expression signature in the brain tissue cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1c6d1e467bea600fb881c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormmluxy
CREEDS IDdz:469
Cell Typebrain tissue
DO IDDOID:14504
Disease NameNiemann-Pick disease
Organismmouse
UMLS CUIC0220756
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM973238, GSM973239, GSM973240, GSM973241, GSM973244, GSM973245, GSM973248, GSM973249, GSM973252, GSM973253, GSM973254, GSM973255, GSM973258, GSM973259, GSM973261, GSM973262
Perturbed SamplesGSM973242, GSM973243, GSM973246, GSM973247, GSM973250, GSM973251, GSM973256, GSM973257, GSM973260, GSM973263, GSM973264
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE39621
Gene Expression Omnibus
Niemann-Pick Type C disease spleen: time course
7
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