Small molecules which reverse Down syndrome
Canned Analysis
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General Information
AccessionDCA00010223
TitleSmall molecules which reverse Down syndrome
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the Down syndrome gene expression signature in the Thymus cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1bc71e467bea600fb8308
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdz:494
Cell TypeThymus
DO IDDOID:14250
Disease NameDown syndrome
Organismhuman
UMLS CUIC0013080
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM589449, GSM589467, GSM589470, GSM589491
Perturbed SamplesGSM589475, GSM589488, GSM589489, GSM589490
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE23910
Gene Expression Omnibus
AIRE hypoexpression and transcriptome profiles correlate with thymic impairment in Down syndrome
7
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