Small molecules which reverse chronic myeloid leukemia
Canned Analysis
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General Information
AccessionDCA00010231
TitleSmall molecules which reverse chronic myeloid leukemia
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the chronic myeloid leukemia gene expression signature in the osteoblastic lineage cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1be90e467bea600fb8418
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatoralanstern
CREEDS IDdz:501
Cell Typeosteoblastic lineage cells
DO IDDOID:8552
Disease Namechronic myeloid leukemia
Organismmouse
UMLS CUIC0023473
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1178732, GSM1178733, GSM1178734, GSM1178735, GSM1178736
Perturbed SamplesGSM1178737, GSM1178738, GSM1178739, GSM1178740, GSM1178741
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE48438
Gene Expression Omnibus
Induced myeloproliferative neoplasm effect on Scl-tTA::TRE-BCR/ABL double-transgenic model of chronic myeloid leukemia: osteoblastic lineage cells
7
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